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Journal articles on the topic 'Lymphotropic introduction'

Author: Grafiati

Published: 28 May 2022

Last updated: 30 July 2025

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1

Duzhyi, I. D., O. L. Sytnik, and G. I. Piatikop. "Clinical results of application of lymphotropic antibioticotherapy in patients with an acute pancreatitis." Ukrainian Journal of Clinical Surgery 90, no. 1 (2023): 27–30. http://dx.doi.org/10.26779/2786-832x.2023.1.27.

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Objective.. To compare the clinical results of application of lymphotropic therapy and standard procedure of parenteral introduction of preparations. Materials and methods. There were studied clinical data, levels of the neutrophil elastase in the blood serum on background of lymphotropic and standard medicinal therapy. Taking into account the above mentioned conditions, the patients were distributed into two groups. Results. Under the influence of lymphotropic therapy in the patients there were observed essential reduction of the neutrophil elastase level in the blood serum and fr

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2

Duzhyi, I. D., V. V. Shimko, G. I. Pyatikop, O. L. Sytnik, and V. Ya Pak. "Peculiarities of course of operational and postoperative periods in appendectomy after various methods of the antibiotics introduction." Klinicheskaia khirurgiia 89, no. 3-4 (2022): 54–58. http://dx.doi.org/10.26779/2522-1396.2022.3-4.54.

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Objective. To study the peculiarities of antibiotics accumulation in appendix vermiformis after various methods of their introduction. Materials and methods. The investigation was conducted in 160 patients, to whom antibiotic was introduced by various methods: 53 – intramuscularly; 52 – intravenously; 55 – lymphotropically. In part of the patients the antibiotic was introduced at 1 h preoperatively, and to the rest – at 2 h. After performance of appendectomy from each third part of the appendix vermiformis (proximal, middle and distal) excised a homogenate was made, which was sowed

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Ginzburg, Harold M. "Human T-cell Lymphotropic Virus, Type-III Diseases: Introduction." Psychiatric Annals 16, no. 3 (1986): 149–50. http://dx.doi.org/10.3928/0048-5713-19860301-06.

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4

Prem, Chand Tard1 Raj Kumar Siyag2 and Vimala Choudhary3. "Marek's Disease in Poultry: Brief Introduction." Science World a monthly e magazine 3, no. 7 (2023): 1756–58. https://doi.org/10.5281/zenodo.8195142.

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Chickens are the main natural host for Marek's disease virus (MDV), a mostly cell-associated but mainly transmitted alpha herpesvirus with lymphotropic properties of gamma herpesviruses. Turkeys can be artificially infected as well as naturally infected quail. However, major clinical outbreaks of Marek's disease in commercial turkey flocks, with mortality from tumors reaching 40%–80% between 8 and 17 weeks of age, were reported in France, Israel, and Germany. One of the most common avian illnesses, Marek's disease has been found in flocks of chickens all around the world.

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Duzhyi, І. D., V. V. Shimko, G. І. Pyatikop, M. G. Kononenko, G. P. Oleshchenko, and D. A. Al Yamani Navras. "Peculiarities of lymphotropic antibioticotherapy in a combat trauma of abdominal organs (clinic-experimental investigation)." Klinicheskaia khirurgiia 88, no. 11-12 (2022): 75–79. http://dx.doi.org/10.26779/2522-1396.2021.11-12.75.

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Objective. Studying of impact of regional lymphotropic antibacterial therapy on various abdominal organs and application of the results in a combat abdominal trauma. Materials and methods. In the experiment accumulation of ceftriaxone in various abdominal organs was investigated, and detected by dimensions of the development zone delay in laboratory culture of E. coli in 1 – 2 h regional lymphotropic introduction of the preparation in a daily dose. Laboratory animals (rabbits) were withdrawn from the experiment, using overdosing of ketamine. After obtaining of specimen from certain organ

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6

Charyshkin, Aleksey, Yevgeniy Toneev, and A. Medvedev. "THE RESULTS OF THE APPLICATION OF LYMPHOTROPIC THERAPY IN PATIENTS LUNG CANCER." Problems in oncology 65, no. 1 (2019): 106–9. http://dx.doi.org/10.37469/0507-3758-2019-65-1-106-109.

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Objectives. To evaluate the results of the application of the developed method of lymphotropic therapy in patients operated on for lung cancer. Methods. Examined 280 patients aged from 39 to 75 years, operated on for lung cancer during the period from 2010 to 2016, Completed: pneumonectomy or forehead - and bilobectomy, lymph node dissection. The patients were divided into three groups. In the first group (n=206) used only standard therapy. In the second group (n=44) in conjunction with standard therapy was performed with an interspinal lymphotropic injections of drugs at the level of Th2 - Th

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Van Dooren, Sonia, Laurent Meertens, Philippe Lemey, Antoine Gessain, and Anne-Mieke Vandamme. "Full-genome analysis of a highly divergent simian T-cell lymphotropic virus type 1 strain in Macaca arctoides." Journal of General Virology 86, no. 7 (2005): 1953–59. http://dx.doi.org/10.1099/vir.0.80520-0.

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Full-genome sequencing and analysis of the highly divergent simian T-cell lymphotropic virus type 1 (STLV-1) strain MarB43 in Macaca arctoides indicated that its open reading frame structure is compatible with proper functioning of its Gag, Pol, Env, Tax and Rex proteins. Detailed analysis of the coding potential, however, revealed that MarB43 is probably forced to use the human T-cell lymphotropic virus type 2/STLV-2 env-tax-rex splice-acceptor homologue and that the proximal pX auxiliary proteins p12I, p13II, p30II and p27I seem to have lost their function. Full-genome (gag-pol-env-tax), lon

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8

Duzhyi, Igor, Мykola Kononenko, Volodymyr Shymko, Oleksandr Sytnik, and Oleksandr Kravets. "JUSTIFICATION OF LYMPHOTROPIC ANTIBACTERIAL THERAPY BENEFITS BASED ON THE CHANGES IN SPECIFIC IMMUNITY PARAMETERS IN ACUTE PANCREATITIS." Eastern Ukrainian Medical Journal 11, no. 1 (2023): 14–20. http://dx.doi.org/10.21272/eumj.2023;11(1):14-20.

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Introduction. The incidence and features of acute pancreatitis stimulate the scientific community and clinicians to look for new antibiotics and new algorithms for their use in treating this disease, which is the world's third most frequent acute surgical disease. Despite this, acute pancreatitis mortality indicates the need for better approaches, especially in conditions of microbial resistance to antibiotics, which determines the urgency of the problem. The objective of the paper was to justify lymphotropic antibacterial therapy as an alternative method of treatment of acute pancreatitis bas

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9

Duzhyi, ID, VV Shymko, IA Pustovoy, HI Piatykop, VV Kuprienko, and UE Kulahina. "Comparison of antibiotic accumulation in appendix with various methods of its injection." Bangladesh Journal of Medical Science 20, no. 2 (2021): 268–73. http://dx.doi.org/10.3329/bjms.v20i2.51534.

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Relevance of the problem: In respect that, lack dynamic of morbidity incidence of acute appendicitis and frequency of postoperative complications, against the backdrop of increasing the number of antibiotics. The problem of prevention of purulent-inflammatory complications during its surgical treatment remains relevant. Materials and methods: The authors compared the intensity of accumulation of ceftriaxone in the appendix tissues depending on the method of injection. Results: It turned out that with the intramuscular injection of ceftriaxone in 1–2 hours before the operation, its

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10

Dzhumabaev, E. S., and S. E. Dzhumabaeva. "Regional pretracheal lymphotropic antibiotic therapy for pulmonary complications of COVID-19." Issues of Reconstructive and Plastic Surgery 26, no. 3 (2023): 42–46. http://dx.doi.org/10.52581/1814-1471/86/05.

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Purpose of the study: to study the pharmacokinetics of gentamicin in pretracheal lymphotropic antibiotic therapy and regional stimulation of interstitial lung lymphatic drainage.Material and methods. Experimental studies consisted of a single administration of gentamicin to 50 mongrel white rats, both sexes, body mass 370–400 g, at a dose of 30 mg/kg: lymphotropically pretracheal, using lidase as a lymphatic drainage stimulator, and intramuscularly, followed by thoracotomy, undertaken to remove the chest cavity organs, paratracheal lymph nodes, and femoral vein puncture, for blood sampling. A

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Duzhyi, Igor, Volodymyr Shymko, Hennadiy Pyatikop, and Vasyl Pak. "EFFECTIVENESS OF LYMPHOTROPIC THERAPY IN THE PATIENTS WITH ACUTE APPENDICITIS AND ITS COMPLICATED FORMS." Eastern Ukrainian Medical Journal 11, no. 2 (2023): 164–70. http://dx.doi.org/10.21272/eumj.2023;11(2):164-170.

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Introduction. Despite using the latest generations of antibiotics and modern methods of their introduction in the surgical treatment of acute appendicitis, purulent-septic complications keep occurring, accounting for 45% of fatal outcomes in the patients operated on for this disease. Materials and methods. Patients were divided into two groups. The main group included patients who were administered antibiotics and pathogenetic drugs locally to the ileocecal zone by means of lymphotropic administration. The comparison group included patients who received standard antibiotic therapy. Results. On

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Popova, M. I., S. A. Stolyarov, and V. A. Badeyan. "CARBOXY-LYMPHOTROPIC THERAPY IN TREATMENT OF SURGICAL SOFT TISSUE INFECTIONS OF LOWER EXTREMITIES." Ulyanovsk Medico-biological Journal, no. 1 (March 5, 2020): 53–62. http://dx.doi.org/10.34014/2227-1848-2020-1-53-62.

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Introduction. So far, surgical soft tissue infection accounts for more than half of all cases seeking specialized medical attendance, and its treatment is sometimes rather difficult. The purpose of the work is to study the results of carboxy-lymphotropic therapy while treating patients with surgical soft tissue infection of the lower extremities. Materials and Methods. The study enrolled 57 patients with manifestations of surgical soft tissue infection of the lower extremities. Criteria for enrollment: patients aged 18 to 75, lack of decompensation for concomitant somatic diseases, and lack of

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Douam, Florian, Louis-Marie Bobay, Guillemette Maurin, et al. "Specialization of Hepatitis C Virus Envelope Glycoproteins for B Lymphocytes in Chronically Infected Patients." Journal of Virology 90, no. 2 (2015): 992–1008. http://dx.doi.org/10.1128/jvi.02516-15.

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ABSTRACTHepatitis C virus (HCV) productively infects hepatocytes. Virion surface glycoproteins E1 and E2 play a major role in this restricted cell tropism by mediating virus entry into particular cell types. However, several pieces of evidence have suggested the ability of patient-derived HCV particles to infect peripheral blood mononuclear cells. The viral determinants and mechanisms mediating such events remain poorly understood. Here, we aimed at isolating viral determinants of HCV entry into B lymphocytes. For this purpose, we constructed a library of full E1E2 sequences isolated from seru

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14

Van Dooren, S., E. Gotuzzo, J. Desmyter, et al. "Evidence for a post-Columbian introduction of human T-cell lymphotropic virus [type I] [corrected] in Latin America." Journal of General Virology 79, no. 11 (1998): 2695–708. http://dx.doi.org/10.1099/0022-1317-79-11-2695.

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15

Petrenko, Nikolay A., Vitaly S. Groshilin, Sergey V. Poroyskiy, Olga V. Voronova, Vladimir D. Kuznetsov, and Yana A. Davydenko. "Application of indirect lymphotropic therapy for purulent-inflammatory diseases of the forearms." Journal of Volgograd State Medical University 22, no. 1 (2025): 138–43. https://doi.org/10.19163/1994-9480-2025-22-1-138-143.

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Objective: Is the improvement of treatment results of patients with phlegmons of the forearm through the development and implementation of a modern complex of therapeutic measures. Materials and methods: In the course of the study the results of treatment of 52 patients with purulent-inflammatory diseases of forearm divided into two clinical groups were analyzed. In Group I (the main group) an original differentiated approach was used followed by the introduction of an algorithm of postoperative management, including the method of indirect lymphotropic antibacterial therapy. For patients of Gr

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16

Radygina, Lubov V., and Larisa V. Mochalova. "Diseases caused by human T-lymphotropic virus type 1 (HTLV-1)." Microbiology Independent Research Journal 11, no. 1 (2024): 57–69. https://doi.org/10.18527/2024115769.

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   <strong>ABSTRACT </strong> <strong>INTRODUCTION: </strong>Human T-lymphotropic virus type 1 (HTLV-1) belongs to the Retroviridae family (genus <em>Deltaretrovirus</em>) and is directly involved in carcinogenesis. The HTLV-1 genome is represented by plus-strand RNA, which is transcribed into proviral DNA and then integrated into the genome of the host cell. After integration, HTLV-1 is present in the cells in the form of a provirus. As in the case of the human immunodeficiency virus, the main targets of HTLV-1 are CD4+ T lymphocytes. The virus is transmitted sexually, through

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17

Tambon, Lucynara Gomes Lima, Ana Paula Quixadá, and Katia Nunes Sá. "Research scenario in physiotherapy for people with human t-cell lymphotropic virus (HTLV): scientometric study / Cenário das pesquisas em Fisioterapia para pessoas com Human T-Cell Lymphotropic Virus (HTLV): estudo cientométrico." Brazilian Journal of Development 8, no. 2 (2022): 12025–42. http://dx.doi.org/10.34117/bjdv8n2-238.

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Introduction: Human T-Cell Lymphotropic Virus (HTLV) is a sexually transmitted retrovirus that can cause chronic pain of moderate to high intensity, spasticity and weakness in the lower limbs, balance, gait, urinary and sexual dysfunctions. Physiotherapy is a treatment that has been shown to be effective in improving symptoms and signs. However, research on the topic is scarce. Objective: Outline the research scenario in Physiotherapy aimed at people infected with HTLV-1. Methods: Scientometric study carried through Medline, Virtual Health Library, Scopus, Web of Science and Google Scholar dat

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18

Duzhyi, I. D., V. V. Shymko, N. J. Alyamani, and H. I. Piatykop. "NEW POSSIBILITIES OF ANTIBIOTIC THERAPY IN THE TREATMENT AND PREVENTION OF I NFECTED ACUTE PANCREATITIS." Kharkiv Surgical School, no. 4 (September 20, 2021): 14–19. http://dx.doi.org/10.37699/2308-7005.4.2021.03.

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Summary. Introduction. One of the most difficult problems in surgery today is the treatment of acute pancreatitis, which remains the third most frequent acute surgical disease. The frequency of the latter is growing every year. Despite the achievements of pharmacotherapy and infusion therapy, mortality in acute pancreatitis remains at the level of 15–45 %, and in the development of purulent complications it reaches 70–80 %. The urgency of the problem. The use of antibiotics for complicated pancreatic necrosis is obvious, but antibiotic therapy does not always lead to the desired result.

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Kukushkin, G. V., and L. P. Sviridkina. "Effect of drugs of various groups on the pharmacokinetics of cefotaxime in comparison with their effect on lymphatic tissue drainage." Regional blood circulation and microcirculation 23, no. 3 (2024): 89–95. http://dx.doi.org/10.24884/1682-6655-2024-23-3-89-95.

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Introduction. The lymphatic system plays a key role in spreading pathogens, including those causing intraabdominal infections. An urgent task of pharmacology is to create methods for the targeted delivery of antibiotics to lymphatic vessels and intestinal tissues. One approach is to use agents acting as endolymphatic conductors to achieve a high drug concentration in the lymphatic system. Aim. To evaluate the effect of various drugs on the concentration of cefotaxime, a third-generation antibiotic, in blood and intestinal tissues, as well as on lymphatic drainage in experiments on mice. Materi

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Del Mistro, Annarosa, Maria Luisa Calabrò, Anna Favero, and Luigi Chieco-Bianchi. "Epidemiology and Etiopathology of Human T-Lymphotropic Viruses: Diagnostic and Clinical Implications for Non-Endemic Areas." Tumori Journal 80, no. 2 (1994): 88–100. http://dx.doi.org/10.1177/030089169408000202.

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Human T-lymphotropic viruses (HTLV) type I and II were first described more than a decade ago. HTLV-I epidemiology and etiopathology are more defined than those of HTLV-II, but conflicting results have been obtained in seroepidemiologic surveys, mainly for difficulties in the discrimination between the two infections. The introduction of advanced serologic and molecular assays has recently provided sensitive and specific tools for diagnosis, and the epidemiologic and etiopathologic patterns linked to these retroviruses are being more precisely defined. Moreover, extensive nucleotide sequence a

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Coutinho, R. A., W. J. Krone, L. Smit, et al. "Introduction of lymphadenopathy associated virus or human T lymphotropic virus (LAV/HTLV-III) into the male homosexual community in Amsterdam." Sexually Transmitted Infections 62, no. 1 (1986): 38–43. http://dx.doi.org/10.1136/sti.62.1.38.

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Florencio, Patrik S., and Erik D. Ramanathan. "Legal Enforcement of Xenotransplantation Public Health Safeguards." Journal of Law, Medicine & Ethics 32, no. 1 (2004): 117–23. http://dx.doi.org/10.1111/j.1748-720x.2004.tb00456.x.

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Xenotransplantation is any transplantation, implantation, or infusion of either live cells, tissues, or organs from a nonhuman animal source, or human bodily fluids, cells, tissues, or organs that have had ex vivo contact with live nonhuman animal cells, tissues, or organs into a human recipient. Most scientists agree that clinical xenotransplantation should not be performed in the absence of accompanying public health safeguards The science upon which that consensus is based has been extensively described in the literature. By and large the most compelling reason for public health safeguards

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Mouinga-Ondémé, Augustin, Larson Boundenga, Ingrid Précilya Koumba Koumba, et al. "Human T-Lymphotropic virus type 1 and human immunodeficiency virus co-infection in rural Gabon." PLOS ONE 17, no. 7 (2022): e0271320. http://dx.doi.org/10.1371/journal.pone.0271320.

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Introduction Human T-cell lymphotrophic virus type-1 (HTLV-1) and human immunodeficiency virus (HIV-1) co-infection occur in many populations. People living with HIV-1 and infected with HTLV-1 seem more likely to progress rapidly towards AIDS. Both HTLV-1 and HIV-1 are endemic in Gabon (Central Africa). We investigated HTLV-1 and HIV-1 co-infection in the Haut-Ogooué province, and assessed factors that may favor the rapid evolution and progression to AIDS in co-infected patients. Methods Plasma samples from HTLV-1 patients were tested using ELISA, and positive samples were then tested by weste

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Kajryak, O. V., and N. B. Gubergrits. "Revisiting the question of endolymphatic therapy." Herald of Pancreatic Club 59, no. 2 (2023): 53–57. http://dx.doi.org/10.33149/vkp.2023.02.10.

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Lymphotropic therapy was the first step in the development of endolymphatic therapy. Lymphotropic therapy was carried out by creating a subcutaneous depot of a contrast agent or injecting the drug directly into the lymph node. The next step was the introduction of the drug into the lymphatic system by a single puncture of the peripheral lymphatic vessel. After G. V. Bondar put his idea into action by making a special tool, it became possible to do long-term endolymphatic infusion. Lymphatic catheterization is performed in a clean operating room. Catheterization of the thigh lymphatic ves

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Pereira Vieira Barreto, Nilo Manoel, Marina Morena Brito Farias, Cíntia de Lima Oliveira, et al. "Evaluation of Strongyloides stercoralis infection in patients with HTLV-1." Biomédica 42, no. 1 (2022): 31–40. http://dx.doi.org/10.7705/biomedica.5888.

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Introduction: Individuals infected with the human T-lymphotropic virus type 1 (HTLV-1) may present severe and disseminated forms of Strongyloides stercoralis infection with low therapeutic response.Objective: To investigate the S. stercoralis infection and the seroprevalence of IgG anti-S. stercoralis antibodies in individuals infected with HTLV-1 attending the Reference Center for HTLV-1 (CHTLV) in Salvador, Bahia, Brazil.Materials and methods: We conducted a cross-sectional study in 178 HTLV-1-infected individuals treated at the HTLV specialized center between January, 2014, and December, 20

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Santos de Souza, Marcela, Juliana Prado Gonçales, Viviane Martha Santos deMorais, et al. "Prevalence and risk factor analysis for HIV/HTLV 1/2 coinfection in Paraíba state, Brazil." Journal of Infection in Developing Countries 15, no. 10 (2021): 1551–54. http://dx.doi.org/10.3855/jidc.14602.

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Introduction: Human T-lymphotropic virus (HTLV) 1 and 2 infections can lead to neurological diseases, mainly in HIV/HTLV 1 coinfected. Furthermore, HTLV 1 infection in HIV/AIDS patients has also been associated with AIDS progression. Despite this, HTLV 1/2 infections are not of mandatory notification in Brazil. Here, we describe the prevalence of HTLV 1/2 in HIV/AIDS patients from Paraíba state, Brazil, as well as the sociodemographic characteristics of the coinfected individuals. Methodology: Information about HIV viral load and TCD4 lymphocyte count were obtained from patients’ records

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Amelie, Martinot, Demar Magalie, Thelusme Liliane, et al. "Uncommon Association Between Diabetic Ketoacidosis, Thyrotoxicosis, Cutaneous Abscess and Acute Pericarditis in an Immunocompetent Patient: A Single Case Report and Literature Review." Current Diabetes Reviews 16, no. 6 (2020): 641–48. http://dx.doi.org/10.2174/1573399815666191025141841.

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Introduction : The typical factors precipitating diabetic ketoacidosis (DKA) include infections (30%), cessation of antidiabetic medication (20%), and a new diagnosis of diabetes (25%). The etiology remains unknown in 25% of cases. Less frequent causes cited in the literature include severe thyrotoxicosis and, infrequently, pericarditis. Few publications have described the role of human T lymphotropic virus type 1 (HTLV-1) in endocrine and metabolic disorders. Based on a clinical case associated with several endocrine and metabolic disorders, we suggest a potential role for HTLV-1, an endemic

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Costa, Galileu Barbosa, Mário Cézar De Oliveira, Sandra Rocha Gadelha, et al. "Infectious diseases during pregnancy in Brazil: seroprevalence and risk factors." Journal of Infection in Developing Countries 12, no. 08 (2018): 657–65. http://dx.doi.org/10.3855/jidc.9492.

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Introduction: Vertically transmitted infections are caused by a diversity of pathogenic microorganisms. Pregnant women are routinely screened to evaluate the risks and reduce the burden of disorders in their unborn children. We assessed the prevalence and possible risk factors for Cytomegalovirus (CMV), Rubella, Human T lymphotropic virus (HTLV), and Toxoplasma gondii in pregnant women from the South region of Bahia State, Brazil. Methodology: Serum samples were obtained from 726 pregnant women aged between 13 and 44 years, with a median age of 24 years. ELISA assays were used to detect

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Andrade, Rafaela Gomes, Maísa Aparecida Ribeiro, Maria Sueli Silva Namen-Lopes, et al. "Evaluation of the use of real-time PCR for human T cell lymphotropic virus 1 and 2 as a confirmatory test in screening for blood donors." Revista da Sociedade Brasileira de Medicina Tropical 43, no. 2 (2010): 111–15. http://dx.doi.org/10.1590/s0037-86822010000200001.

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INTRODUCTION: HTLV-1/2 screening among blood donors commonly utilizes an enzyme-linked immunosorbent assay (EIA), followed by a confirmatory method such as Western blot (WB) if the EIA is positive. However, this algorithm yields a high rate of inconclusive results, and is expensive. METHODS: Two qualitative real-time PCR assays were developed to detect HTLV-1 and 2, and a total of 318 samples were tested (152 blood donors, 108 asymptomatic carriers, 26 HAM/TSP patients and 30 seronegative individuals). RESULTS: The sensitivity and specificity of PCR in comparison with WB results were 99.4% and

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Hock, RA, AD Miller, and WR Osborne. "Expression of human adenosine deaminase from various strong promoters after gene transfer into human hematopoietic cell lines." Blood 74, no. 2 (1989): 876–81. http://dx.doi.org/10.1182/blood.v74.2.876.876.

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Abstract Adenosine deaminase (ADA) deficiency is associated with a fatal severe combined immunodeficiency. Because most patients do not have a suitable marrow donor, the introduction of a normal ADA gene into the patient's marrow cells is a potentially useful alternative therapy. To identify vectors that provide optimal gene expression in human hematopoietic cells, we investigated retroviral vectors containing the ADA gene under the transcriptional control of the promoter/enhancers of Moloney murine leukemia virus, the simian virus 40 early region, the cytomegalovirus immediate-early gene, the

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Hock, RA, AD Miller, and WR Osborne. "Expression of human adenosine deaminase from various strong promoters after gene transfer into human hematopoietic cell lines." Blood 74, no. 2 (1989): 876–81. http://dx.doi.org/10.1182/blood.v74.2.876.bloodjournal742876.

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Adenosine deaminase (ADA) deficiency is associated with a fatal severe combined immunodeficiency. Because most patients do not have a suitable marrow donor, the introduction of a normal ADA gene into the patient's marrow cells is a potentially useful alternative therapy. To identify vectors that provide optimal gene expression in human hematopoietic cells, we investigated retroviral vectors containing the ADA gene under the transcriptional control of the promoter/enhancers of Moloney murine leukemia virus, the simian virus 40 early region, the cytomegalovirus immediate-early gene, the lymphotr

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Liao, Qiao, Zhengang Shan, Min Wang, et al. "Prevalence and evolutionary analyses of human T-cell lymphotropic virus in Guangdong province, China: Transcontinental and Japanese subtype lineages dominate the prevalence." PLOS Neglected Tropical Diseases 15, no. 2 (2021): e0009043. http://dx.doi.org/10.1371/journal.pntd.0009043.

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To systematically characterize the prevalence and evolution of human T-cell lymphotropic virus (HTLV) infection among voluntary blood donors (BDs) in Guangdong province, China. A three-year survey for HTLV epidemiology among BDs was performed in Guangdong during 2016–2018. Anti-HTLV-1/2 was screened by ELISA and ECLIA, and subsequently confirmed by western blot (WB) and nucleic acid testing (NAT). The prevalence of HTLV in donors from different cities was calculated. The identified HTLV-positive cases were phylogenetically genotyped and analyzed in a Bayesian phylogenetic framework. Among 3,26

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Dias-Bastos, Maria Regina, Cláudia Di Lorenzo Oliveira, and Anna Bárbara de Freitas Carneiro-Proietti. "Decline in prevalence and asymmetric distribution of human T cell lymphotropic virus 1 and 2 in blood donors, State of Minas Gerais, Brazil, 1993 to 2007." Revista da Sociedade Brasileira de Medicina Tropical 43, no. 6 (2010): 615–19. http://dx.doi.org/10.1590/s0037-86822010000600002.

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INTRODUCTION: Human T cell lymphotropic virus types 1 and 2 (HTLV-1/2) are endemic in Brazil and are screened for in transfusion services since 1993. This study evaluated the evolution of the prevalence of HTLV-1 and 2 in blood donors of the Hemominas Foundation from 1993 to 2007, and its geographical distribution in State of Minas Gerais, Brazil. METHODS: The Hemominas Foundation is a centralized blood center in Minas Gerais, Brazil. The sources of data were the Hemominas Foundation Technical Bulletin and files from the centralized serological laboratory. Donors were tested in the period usin

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Diab-Assaf, Mona, Josiane Semaan, Marwan El-Sabban та ін. "Inhibition of Proliferation and Induction of Apoptosis by Thymoquinone via Modulation of TGF Family, p53, p21 and Bcl-2α in Leukemic Cells". Anti-Cancer Agents in Medicinal Chemistry 18, № 2 (2018): 210–15. http://dx.doi.org/10.2174/1871520617666170912133054.

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Introduction: Adult T-cell leukemia (ATL) is an aggressive form of malignancy caused by human T- cell lymphotropic virus 1 (HTLV-1). Currently, there is no effective treatment for ATL. Thymoquinone has been reported to have anti-cancer properties. Objective: The aim of this study is to investigatthe effects of TQ on proliferation, apoptosis induction and the underlying mechanism of action in both HTLV-1 positive (C91-PL and HuT-102) and HTLV-1 negative (CEM and Jurkat) malignant T-lymphocytes. Materials and Methods: Cells were incubated with different thymoquinone concentrations for 24h. Cell

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Souza, Verônica Guimarães de, Marina Lobato Martins, Anna Bárbara de Freitas Carneiro-Proietti, et al. "High prevalence of HTLV-1 and 2 viruses in pregnant women in São Luis, state of Maranhão, Brazil." Revista da Sociedade Brasileira de Medicina Tropical 45, no. 2 (2012): 159–62. http://dx.doi.org/10.1590/s0037-86822012000200004.

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INTRODUCTION: Human T cell lymphotropic virus type 1 (HTLV-1) is endemic in the Caribbean, Japan, South America and regions of Africa. HTLV-2 is present in Native American populations and associated with IV drug use in Europe and North America. In Brazil, it is estimated that 1.5 million people are infected with HTLV-1/2. The study objective was to determine HTLV-1/2 prevalence in pregnant women in the prenatal care from three public services in São Luis, State of Maranhão, Brazil, and to counsel seropositive women to reduce viral transmission. METHODS: A cross-sectional study was conducted fr

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Dougan, S., Alan Smith, J. C. Tosswill, K. Davison, M. Zuckerman, and G. P. Taylor. "New diagnoses of HTLV infection in England and Wales: 2002-2004." Eurosurveillance 10, no. 10 (2005): 3–4. http://dx.doi.org/10.2807/esm.10.10.00569-en.

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Human T cell lymphotropic viruses (HTLV) are retroviruses transmitted through breastfeeding, sexual contact, blood transfusion and injecting drug use. HTLV is endemic in the Caribbean, and parts of Africa, Japan and South America, with isolated foci in other areas. Infection is life long. Fewer than 5% of those infected progress to one of the HTLV-related diseases, but these are debilitating and often fatal. In England and Wales, laboratory and clinical reports of new HTLV diagnoses are routinely collected, including infections identified by the blood service since the introduction of anti-HTL

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Minshawi, Faisal, Asim A. Abdulshakoor, Emran M. Alwakil, et al. "Seroprevalence of transfusion-transmitted infections among blood donors in Makkah, Saudi Arabia." Journal of Infection in Developing Countries 18, no. 06 (2024): 957–63. http://dx.doi.org/10.3855/jidc.19559.

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Introduction: Blood donation is vital for healthcare; however, transfusion-transmitted infections (TTIs) pose a serious risk. This study investigated the seroprevalence of TTIs among Saudi blood donors. Methodology: This retrospective study included male blood donors aged ≥ 18 years who donated blood at Al-Noor Specialist Hospital in Makkah from January 2017 to December 2022. The blood units were screened for hepatitis B surface antigen (HBsAg) and core antibodies (HBc-IgG), hepatitis C antibodies (HCV-Abs), syphilis, HIV-1 antigen/antibody (HIV-1 Ag/Ab), human T-lymphotropic virus 1, 2 (HTLV-

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Georgia Koopmans, Imogen Emily, and Chee Kuan Chuah. "P-249 WHAT IS THE PREVALENCE OF HUMAN T-CELL LYMPHOTROPIC VIRUS-1 (HTLV-1) IN HEALTHCARE WORKERS (HCWS) WORLDWIDE? A REVIEW OF THE LITERATURE." Occupational Medicine 74, Supplement_1 (2024): 0. http://dx.doi.org/10.1093/occmed/kqae023.0821.

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Abstract Introduction HTLV-1 is a retrovirus with long latency that can cause severe disease, transmitted through breastfeeding, blood or sexual contact. It is estimated to affect 5 to 10 million people worldwide which is of growing concern, with higher prevalence in parts of Africa, the Caribbean, South America and Southern Japan. Prevalence of HTLV-1 among HCWs is important in the context of exposure prone procedures and the possible onward transmission risk to patients, as well as understanding the risk of occupational-acquired infection through body fluid exposures. Methods A literature se

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Kalnina, Lyudmila B., Lyudmila M. Selimova, and Dmitry N. Nosik. "Evaluation of anti-HIV-1 (Retroviridae: Orthoretrovirinae: Lentivirus: Human immunodeficiency virus type 1) activity of 6HP and 3TC in vitro using MT-4 cell line variants with different replicative activity." Problems of Virology 69, no. 5 (2024): 441–48. http://dx.doi.org/10.36233/0507-4088-247.

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Introduction. Chemotherapy of HIV infection remains the only means of treating the disease. The process of development new and improving previously developed drugs is therefore considered a priority. One of the preclinical stage of drug efficacy testing is research in the virus-cell model system in vitro. The aim. To evaluate the antiviral efficacy of nucleoside reverse transcriptase inhibitors (NRTIs) 6HP and 3TC during HIV-1 replication in the neoplastic MT-4 cell line. Materials and methods. Two variants of the CD4+ T-lymphocyte MT-4 cell line (MT-4/1 and MT-4/2) transformed by Human T-lymp

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Bordallo, Luísa, Iris Montaño-Castellón, Liliane Lins-Kusterer, and Carlos Brites. "Cognitive Assessment in HTLV-1 Patients Followed Up at a Reference Center in Salvador, Brazil." Viruses 16, no. 10 (2024): 1569. http://dx.doi.org/10.3390/v16101569.

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Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1) is endemic to Brazil, and there is still no specific treatment for these patients. The literature shows that few studies have described the cognitive impairment associated with an HTLV-1 infection, with none of them examining the population of Salvador, where there are approximately forty thousand people infected with the virus. Objectives: To determine the prevalence of cognitive impairment among individuals with HTLV-1. In addition, investigate whether sociodemographic aspects, time since the diagnosis of infection, and the diagno

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Busch, Michael P., Evan M. Bloch, and Steven Kleinman. "Prevention of transfusion-transmitted infections." Blood 133, no. 17 (2019): 1854–64. http://dx.doi.org/10.1182/blood-2018-11-833996.

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Abstract Since the 1970s, introduction of serological assays targeting virus-specific antibodies and antigens has been effective in identifying blood donations infected with the classic transfusion-transmitted infectious agents (TTIs; hepatitis B virus [HBV], HIV, human T-cell lymphotropic virus types I and II, hepatitis C virus [HCV]). Subsequently, progressive implementation of nucleic acid–amplification technology (NAT) screening for HIV, HCV, and HBV has reduced the residual risk of infectious-window-period donations, such that per unit risks are &lt;1 in 1 000 000 in the United States

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Efiom-Ekaha, Daniel, Joseph Feldman, Susan Gottesman, et al. "Infusional Adriamycin Based Chemotherapy Significantly Improves the Survival of Human T-Cell Lymphotropic Virus-I Induced Acute Type Adult T-Cell Leukemia Lymphoma." Blood 106, no. 11 (2005): 2684. http://dx.doi.org/10.1182/blood.v106.11.2684.2684.

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Abstract Introduction: In this retrospective analysis, we provide a comprehensive account of the pathophysiology, clinical course and outcomes with various therapeutic regimens in HTLV-1 associated Adult T-cell Lymphoma/Leukemia- The Brooklyn Experience. Patients and Methods: We retrospectively reviewed the medical records of all patients identified as having acute type Human T-cell Lymphotropic Virus (HTLV-I) associated Adult T-cell Leukemia/Lymphoma (ATLL), from 1995 to 2005. The diagnosis was made according to REAL and WHO classification and based on clinical presentation, tissue biopsy and

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Prasetyo, Afiono Agung, Paramasari Dirgahayu, Yulia Sari, Hudiyono Hudiyono, and Seiji Kageyama. "Molecular epidemiology of HIV, HBV, HCV, and HTLV-1/2 in drug abuser inmates in central Javan prisons, Indonesia." Journal of Infection in Developing Countries 7, no. 06 (2013): 453–67. http://dx.doi.org/10.3855/jidc.2965.

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Introduction: This study was conducted to determine the current molecular prevalence of human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), and human T lymphotropic virus-1/2 (HTLV-1/2) circulating among drug abuser inmates incarcerated in prisons located in Central Java, Indonesia. Methodology: Socio-epidemiological data and blood specimens were collected from 375 drug abuser inmates in four prisons. The blood samples were analyzed with serological and molecular testing for HIV, HBV, HCV, HDV, and HTLV-1/2. Results: The seroprevalence

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Souan, Lina, Faten Tout, Mahmoud Siag, and Maher A. Sughayer. "Seroprevalence rates of transfusion-transmitted infections among blood donors in Jordan." Journal of Infection in Developing Countries 10, no. 04 (2016): 377–83. http://dx.doi.org/10.3855/jidc.8160.

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Introduction: Statistics on the prevalence of donor screening for hepatitis B surface antigen (HBsAg) and anti-hepatitis C virus (anti-HCV) in Jordan are outdated. There are no studies on the prevalence of anti-HIV I/II, anti-human T-cell lymphotropic virus type I and II (anti-HTLV-I/II), or anti-syphilis. Data are also lacking on the prevalence and significance of using anti-HBc screening in Jordan. This study aimed to evaluate the prevalence of transfusion-transmissible infections (TTI) among donors at King Hussein Cancer Center and compare it with neighboring countries and to evaluate the s

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Rafat Panah Bayegi, Houshang, Lida Jarahi, Milad Mahmoudabadi, Masoumeh Sarbaz, Seyyedeh Fatemeh Mousavi Baigi, and Khalil Kimiafar. "Assess the Knowledge of Medical Students About HTLV-1 in Mashhad University of Medical Science." Frontiers in Health Informatics 11, no. 1 (2022): 125. http://dx.doi.org/10.30699/fhi.v11i1.394.

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Introduction: Human T-cell lymphotropic virus type 1 (HTLV-1) is known to be endemic in the population of northeastern Iran. This study was conducted with the aim of investigating the knowledge and attitude of medical students of Mashhad University of Medical Sciences about the HTLV-1 virus.Material and Methods: The present study was a descriptive-analytical study that was conducted in Mashhad Medical School from April to June 2014. The research population included all medical students studying at the time of the study (307 people). The tool of data collection was a questionnaire including 4 p

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Bridgelall, S., J. Michalski, X. Zhang, L. Sokol, N. Dong, and L. Zhang. "Single Institutional Experience on Cutaneous Manifestation of Adult T-cell Leukemia/Lymphoma - Potential Diagnostic Pitfall." American Journal of Clinical Pathology 154, Supplement_1 (2020): S96—S97. http://dx.doi.org/10.1093/ajcp/aqaa161.211.

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Abstract Introduction/Objective Adult T-cell Leukemia/Lymphoma (ATLL) is an aggressive peripheral T-cell neoplasm caused by the human T-cell lymphotropic virus-1 (HTLV1). Approximately half of the patients diagnosed with ATLL have heterogeneous cutaneous manifestations and 1/3 of those patients have skin changes e.g. rashes, papules, and nodules at initial presentation. There is clinical and morphologic overlap between ATLL and other cutaneous T-cell neoplasms such as Cutaneous T-Cell Lymphoma/mycosis fungoides (CTCL/MF) which could pose a potential diagnostic challenge. Methods A retrospectiv

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Enriquez, Daniel J., Jhoisy Casas, Gustavo Sandival, et al. "Frequency and Survival of T-Cell Lymphomas in Peru: Initial Report of a Peruvian Registry Experience." Blood 138, Supplement 1 (2021): 1374. http://dx.doi.org/10.1182/blood-2021-154330.

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Abstract Introduction: T-cell lymphomas are a relatively rare and heterogeneous group of lymphoid neoplasms. Its incidence relies on viral infections incidence as Human T-cell lymphotropic virus type I-II (HTLV-I/II) and Ebstein Bar virus (EBV). Specifically, these viruses have a significantly higher incidence in Latin-American populations. Our objective was to calculate the incidence and survival of T-cell lymphomas in the largest Peruvian population based on a national registry. Methods: We conducted a multicenter, retrospective registry study of non-Hodgkin T cell lymphoma. The data was ext

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Andrianov, A. V., M. V. Drozdova, and Yu S. Preobrazhenskaya. "Features of the pathology of the lymphoid ring of the pharynx in children during the COVID-19 pandemic." Meditsinskiy sovet = Medical Council, no. 23 (January 19, 2023): 330–34. http://dx.doi.org/10.21518/2079-701x-2022-16-23-330-334.

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Introduction. For many years, one of the problems in medicine that attracted the attention of specialists from different areas of medicine was herpes virus infection. There are many reasons for this, including the often persistent nature of the course, a wide variety of clinical manifestations and routes of transmission, and many target organs of this infection. The disease can proceed in different ways, it has both asymptomatic, mild and rather severe course. For otorhinolaryngologists, Epstein-Barr virus (EBV), cytomegalovirus (CMV) and herpes virus 6 (HHV-6) are the most relevant and import

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Kozako, Tomohiro, Akiyoshi Aikawa, Takeo Ohsugi, and Shin-Ichiro Honda. "AICAR Induces AMPK-Independent Cell Death in Adult T-Cell Leukemia/Lymphoma and Has Anti-Tumor Activity." Blood 142, Supplement 1 (2023): 7146. http://dx.doi.org/10.1182/blood-2023-173246.

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Introduction: Adult T-cell leukemia/lymphoma (ATL) is an aggressive T cell leukemia/lymphoma caused by human T-cell lymphotropic virus type I (HTLV-1) and has a poor outcome. Recently, we reported that AMPKα, the catalytic unit of AMP-activated protein kinase (AMPK), is highly expressed in cells from patients with ATL and that an AMPK inhibitor had anti-tumor activity in ATL mice 1. On the other hand, acadesine or 5-aminoimidazole-4-carboxamide riboside (AICAR) is anAMPK activator, and was recently shown to have tumor suppressive effects on B cell chronic lymphocytic leukemia via the activatio

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Khan, Aliya M., Sophia Navajas Urisote, and Danish A. Sheikh. "Abstract B043: Challenges in managing cancer patients with congenital coronary artery anomalies: A case report." Cancer Epidemiology, Biomarkers & Prevention 32, no. 12_Supplement (2023): B043. http://dx.doi.org/10.1158/1538-7755.disp23-b043.

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Abstract Introduction: Congenital coronary artery anomalies are rare cardiac abnormalities that can increase the risk of sudden cardiac death, particularly during exercise. Patients with cancer and concurrent coronary artery disease face higher mortality risks, as they often receive delayed percutaneous coronary intervention. Additionally, anthracycline chemotherapy, commonly used in cancer treatment, can cause cardiotoxicity and worsen pre-existing cardiac abnormalities. Despite the complexity of managing cancer patients with coronary artery anomalies, there is a lack of clear guidelines and

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