Relevant bibliographies by topics / Lysosphingolipids

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters

Academic literature on the topic 'Lysosphingolipids'

Author: Grafiati
Published: 4 June 2025
Last updated: 1 August 2025

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Journal articles on the topic "Lysosphingolipids"

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Dubot, Patricia, Leonardo Astudillo, Nicole Therville, et al. "Potential Role of Sphingolipidoses-Associated Lysosphingolipids in Cancer." Cancers 14, no. 19 (2022): 4858. http://dx.doi.org/10.3390/cancers14194858.

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Sphingolipids play a key structural role in cellular membranes and/or act as signaling molecules. Inherited defects of their catabolism lead to lysosomal storage diseases called sphingolipidoses. Although progress has been made toward a better understanding of their pathophysiology, several issues still remain unsolved. In particular, whether lysosphingolipids, the deacylated form of sphingolipids, both of which accumulate in these diseases, are simple biomarkers or play an instrumental role is unclear. In the meanwhile, evidence has been provided for a high risk of developing malignancies in
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Stahl-Meyer, Kamilla, Mesut Bilgin, Lya K. K. Holland, et al. "Galactosyl- and glucosylsphingosine induce lysosomal membrane permeabilization and cell death in cancer cells." PLOS ONE 17, no. 11 (2022): e0277058. http://dx.doi.org/10.1371/journal.pone.0277058.

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Isomeric lysosphingolipids, galactosylsphingosine (GalSph) and glucosylsphingosine (GlcSph), are present in only minute levels in healthy cells. Due to defects in their lysosomal hydrolysis, they accumulate at high levels and cause cytotoxicity in patients with Krabbe and Gaucher diseases, respectively. Here, we show that GalSph and GlcSph induce lysosomal membrane permeabilization, a hallmark of lysosome-dependent cell death, in human breast cancer cells (MCF7) and primary fibroblasts. Supporting lysosomal leakage as a causative event in lysosphingolipid-induced cytotoxicity, treatment of MCF
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Kopytova, A. E., T. S. Usenko, A. I. Bezrukova, et al. "Elevated Level of Blood Lysosphingolipids in Patients with Schizophrenia." Генетика 59, no. 6 (2023): 670–75. http://dx.doi.org/10.31857/s0016675823060085.

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Schizophrenia is a mental disorder with a prevalence of 0.7–1% of the general population and is characterized by impaired dopamine transmission in neurons. Recent data have shown that lysosomal storage disorders (LSD), characterized by a decrease in enzyme activity and a corresponding accumulation of substrate in lysosomes due to mutations in lysosomal genes, can manifest a wide range of clinical symptoms including psychosis, affective disorders, early onset dementia and schizophrenia. The purpose of this study was to assess the level of lysosphingolipids in patients with schizophrenia, Parkin
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Fiore, S., K. C. Nicolaou, T. Caulfield, H. Kataoka, and C. N. Serhan. "Evaluation of synthetic sphingosine, lysosphingolipids and glycosphingolipids as inhibitors of functional responses of human neutrophils." Biochemical Journal 266, no. 1 (1990): 25–31. http://dx.doi.org/10.1042/bj2660025.

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Human neutrophils, when exposed to soluble stimuli, aggregate, release oxygenated products of arachidonic acid and generate active oxygen species. Sphingolipid-derived products such as sphingosine and lysosphingolipids have been shown to exert selective actions on a variety of cell types, including neutrophils. Therefore, to determine the structural basis for selective inhibition of neutrophil responses by naturally occurring sphingolipids, seven compounds were prepared by total organic synthesis, and their impact on neutrophils in suspension has been studied. The compounds synthesized include
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5

Paraskevopoulos, Georgios, Lukáš Opálka, Andrej Kováčik, et al. "Lysosphingolipids in ceramide-deficient skin lipid models." Journal of Lipid Research 66, no. 1 (2024): 100722. https://doi.org/10.5281/zenodo.14738300.

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Ceramides are key components of the skin's permeability barrier. In atopic dermatitis, pathological hydrolysis of ceramide precursors - glucosylceramides and sphingomyelin - into lysosphingolipids, specifically glucosylsphingosine (GS) and sphingosine-phosphorylcholine (SPC), and free fatty acids (FFAs) has been proposed to contribute to impaired skin barrier function. This study investigated whether replacing ceramides with lysosphingolipids and FFAs in skin lipid barrier models would exacerbate barrier dysfunction. When applied topically to human stratum corneum sheets, SPC and GS increased
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6

Polo, Giulia, Alessandro P. Burlina, Enzo Ranieri, et al. "Plasma and dried blood spot lysosphingolipids for the diagnosis of different sphingolipidoses: a comparative study." Clinical Chemistry and Laboratory Medicine (CCLM) 57, no. 12 (2019): 1863–74. http://dx.doi.org/10.1515/cclm-2018-1301.

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Abstract Background Lysosphingolipids, the N-deacylated forms of sphingolipids, have been identified as potential biomarkers of several sphingolipidoses, such as Gaucher, Fabry, Krabbe and Niemann-Pick diseases and in GM1 and GM2 gangliosidoses. To date, different methods have been developed to measure various lysosphingolipids (LysoSLs) in plasma. Here, we present a novel liquid chromatography tandem mass spectrometry (LC-MS/MS) assay for a simultaneous quantification of LysoSLs (HexSph, LysoGb3, LysoGM1, LysoGM2, LysoSM and LysoSM509) in dried blood spot (DBS). This LC-MS/MS method was used
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Bell, R. M., C. R. Loomis, and Y. A. Hannun. "Protein Kinase C Regulation by Sphingosine/Lysosphingolipids." Cold Spring Harbor Symposia on Quantitative Biology 53 (January 1, 1988): 103–10. http://dx.doi.org/10.1101/sqb.1988.053.01.016.

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8

Spassieva, Stefka, and Erhard Bieberich. "Lysosphingolipids and sphingolipidoses: Psychosine in Krabbe's disease." Journal of Neuroscience Research 94, no. 11 (2016): 974–81. http://dx.doi.org/10.1002/jnr.23888.

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9

Nofer, Jerzy-Roch, and Gerd Assmann. "Atheroprotective Effects of High-Density Lipoprotein-Associated Lysosphingolipids." Trends in Cardiovascular Medicine 15, no. 7 (2005): 265–71. http://dx.doi.org/10.1016/j.tcm.2005.08.005.

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Hannun, Y., and R. Bell. "Lysosphingolipids inhibit protein kinase C: implications for the sphingolipidoses." Science 235, no. 4789 (1987): 670–74. http://dx.doi.org/10.1126/science.3101176.

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Dissertations / Theses on the topic "Lysosphingolipids"

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Lafargue, Audrey. "Étude mécanistique & fonctionnelle de la sénescence radio-induite des cellules endothéliales microvasculaires." Nantes, 2014. http://archive.bu.univ-nantes.fr/pollux/show.action?id=920fc9d7-fa70-4586-9662-a4f810b303d0.

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Les bénéfices de la radiothérapie reposent sur une balance mettant en jeu la réponse anti-tumorale et la toxicité sur les tissus sains périphériques. La Sphingosine-1-Phosphate (S1P) permet de limiter la radio-toxicité aigue en prévenant la mort cellulaire dépendante du Céramide des cellules endothéliales microvasculaires. Cependant, de nombreuses observations physiopathologiques indiquent que les cellules endothéliales jouent également un rôle essentiel dans le développement de la radio-toxicité tardive, et peut être conditionné par leur entrée en sénescence prématurée. La S1P, en protégeant
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Hu, Jiancheng. "Regulation of Lsc activity and role in B cell migration and antigen receptor signaling /." Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.

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Thesis (Ph.D. in Immunology) -- University of Colorado Denver, 2007.<br>Typescript. Includes bibliographical references (leaves 103-118). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
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Geigenmüller, Sven [Verfasser]. "HDL und HDL-assoziierte Lysosphingolipide als Regulatoren der Expression von Zelladhäsionsmolekülen in humanen vaskulären Endothelzellen / vorgelegt von Geigenmüller, Sven." 2005. http://d-nb.info/99272600X/34.

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Books on the topic "Lysosphingolipids"

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Sphingosine-1-Phosphate Signaling in Immunology and Infectious Diseases. Springer International Publishing AG, 2014.

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Book chapters on the topic "Lysosphingolipids"

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Bell, Robert M., Carson R. Loomis, and Yusuf A. Hannun. "Regulation of Protein Kinase C by Sphingosine/Lysosphingolipids." In Cellular and Molecular Aspects of Inflammation. Springer US, 1988. http://dx.doi.org/10.1007/978-1-4684-5487-1_13.

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Goetzl, Edward J., and Songzhu An. "A Subfamily of G Protein-Coupled Cellular Receptors for Lysophospholipids and Lysosphingolipids." In Advances in Experimental Medicine and Biology. Springer US, 1999. http://dx.doi.org/10.1007/978-1-4615-4793-8_38.

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3

Stauffer, Brandon B., and Chunli Yu. "Plasma Lysosphingolipid Biomarker Measurement by Liquid Chromatography Tandem Mass Spectrometry." In Clinical Applications of Mass Spectrometry in Biomolecular Analysis. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2565-1_25.

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4

"Lysosphingolipids." In Encyclopedia of Molecular Pharmacology. Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-57401-7_300327.

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You might also be interested in the extended bibliographies on the topic 'Lysosphingolipids' for particular source types:
Journal articles
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