Relevant bibliographies by topics / Lysostaphin resistance

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Academic literature on the topic 'Lysostaphin resistance'

Author: Grafiati
Published: 4 June 2021
Last updated: 27 April 2022

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Journal articles on the topic "Lysostaphin resistance"

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Climo, Michael W., Kerstin Ehlert, and Gordon L. Archer. "Mechanism and Suppression of Lysostaphin Resistance in Oxacillin-Resistant Staphylococcus aureus." Antimicrobial Agents and Chemotherapy 45, no. 5 (2001): 1431–37. http://dx.doi.org/10.1128/aac.45.5.1431-1437.2001.

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ABSTRACT The potential for the development of resistance in oxacillin-resistant Staphylococcus aureus (ORSA) to lysostaphin, a glycylglycine endopeptidase produced byStaphylococcus simulans biovar staphylolyticus, was examined in vitro and in an in vivo model of infection. Following in vitro exposure of ORSA to subinhibitory concentrations of lysostaphin, lysostaphin-resistant mutants were idenitifed among all isolates examined. Resistance to lysostaphin was associated with a loss of resistance to β-lactams and a change in the muropeptide interpeptide cross bridge from pentaglycine to a single
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Gründling, Angelika, Dominique M. Missiakas, and Olaf Schneewind. "Staphylococcus aureus Mutants with Increased Lysostaphin Resistance." Journal of Bacteriology 188, no. 17 (2006): 6286–97. http://dx.doi.org/10.1128/jb.00457-06.

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ABSTRACT Staphylococcus simulans secretes lysostaphin, a bacteriolytic enzyme that specifically binds to the cell wall envelope of Staphylococcus aureus and cleaves the pentaglycine cross bridges of peptidoglycan, thereby killing staphylococci. The study of S. aureus mutants with resistance to lysostaphin-mediated killing has revealed biosynthetic pathways for cell wall assembly. To identify additional genes involved in cell wall envelope biosynthesis, we have screened a collection of S. aureus strain Newman transposon mutants for lysostaphin resistance. Bursa aurealis insertion in SAV2335, en
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Batool, Nayab, Kwan Soo Ko, Akhilesh Kumar Chaurasia, and Kyeong Kyu Kim. "Functional Identification of Serine Hydroxymethyltransferase as a Key Gene Involved in Lysostaphin Resistance and Virulence Potential of Staphylococcus aureus Strains." International Journal of Molecular Sciences 21, no. 23 (2020): 9135. http://dx.doi.org/10.3390/ijms21239135.

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Gaining an insight into the mechanism underlying antimicrobial-resistance development in Staphylococcus aureus is crucial for identifying effective antimicrobials. We isolated S. aureus sequence type 72 from a patient in whom the S. aureus infection was highly resistant to various antibiotics and lysostaphin, but no known resistance mechanisms could explain the mechanism of lysostaphin resistance. Genome-sequencing followed by subtractive and functional genomics revealed that serine hydroxymethyltransferase (glyA or shmT gene) plays a key role in lysostaphin resistance. Serine hydroxymethyltra
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Kusuma, Caroline, Anna Jadanova, Tanya Chanturiya, and John F. Kokai-Kun. "Lysostaphin-Resistant Variants of Staphylococcus aureus Demonstrate Reduced Fitness In Vitro and In Vivo." Antimicrobial Agents and Chemotherapy 51, no. 2 (2007): 475–82. http://dx.doi.org/10.1128/aac.00786-06.

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ABSTRACT Lysostaphin is under development as a therapy for serious staphylococcal infections. During preclinical development, lysostaphin-resistant Staphylococcus aureus variants have occasionally been reported in vitro and in vivo. The acquisition of resistance to this drug, however, leads to a significant increase in β-lactam antibiotic susceptibility, rendering methicillin-resistant S. aureus (MRSA) strains functionally methicillin susceptible. In this study, we have demonstrated that the development of lysostaphin resistance by two strains of MRSA also led to a loss of fitness in the varia
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Heath Farris, M., Lucie S. Heath, Harry E. Heath, Paul A. LeBlanc, Robin S. Simmonds, and Gary L. Sloan. "Expression of the genes for lysostaphin and lysostaphin resistance in streptococci." FEMS Microbiology Letters 228, no. 1 (2003): 115–19. http://dx.doi.org/10.1016/s0378-1097(03)00743-2.

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6

Gargis, Shaw R., Harry E. Heath, Paul A. LeBlanc, Linda Dekker, Robin S. Simmonds, and Gary L. Sloan. "Inhibition of the Activity of Both Domains of Lysostaphin through Peptidoglycan Modification by the Lysostaphin Immunity Protein." Applied and Environmental Microbiology 76, no. 20 (2010): 6944–46. http://dx.doi.org/10.1128/aem.01066-10.

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ABSTRACT Resistance to lysostaphin, a staphylolytic glycylglycine endopeptidase, is due to a FemABX-like immunity protein that inserts serines in place of some glycines in peptidoglycan cross bridges. These modifications inhibit both binding of the recombinant cell wall targeting domain and catalysis by the recombinant catalytic domain of lysostaphin.
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Hertlein, Tobias, Volker Sturm, Udo Lorenz, K. Sumathy, Peter Jakob, and Knut Ohlsen. "Bioluminescence and19F Magnetic Resonance Imaging Visualize the Efficacy of Lysostaphin Alone and in Combination with Oxacillin against Staphylococcus aureus in Murine Thigh and Catheter-Associated Infection Models." Antimicrobial Agents and Chemotherapy 58, no. 3 (2013): 1630–38. http://dx.doi.org/10.1128/aac.01422-13.

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ABSTRACTStaphylococci are the leading cause of hospital-acquired infections worldwide. Increasingly, they resist antibiotic treatment owing to the development of multiple antibiotic resistance mechanisms in most strains. Therefore, the activity and efficacy of recombinant lysostaphin as a drug against this pathogen have been evaluated. Lysostaphin exerts high levels of activity against antibiotic-resistant strains ofStaphylococcus aureus, including methicillin-resistantS. aureus(MRSA). The therapeutic value of lysostaphin has been analyzed in two different clinically relevantin vivomodels, a c
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8

Wu, Julie A., Caroline Kusuma, James J. Mond, and John F. Kokai-Kun. "Lysostaphin Disrupts Staphylococcus aureus and Staphylococcus epidermidis Biofilms on Artificial Surfaces." Antimicrobial Agents and Chemotherapy 47, no. 11 (2003): 3407–14. http://dx.doi.org/10.1128/aac.47.11.3407-3414.2003.

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ABSTRACT Staphylococci often form biofilms, sessile communities of microcolonies encased in an extracellular matrix that adhere to biomedical implants or damaged tissue. Infections associated with biofilms are difficult to treat, and it is estimated that sessile bacteria in biofilms are 1,000 to 1,500 times more resistant to antibiotics than their planktonic counterparts. This antibiotic resistance of biofilms often leads to the failure of conventional antibiotic therapy and necessitates the removal of infected devices. Lysostaphin is a glycylglycine endopeptidase which specifically cleaves th
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9

Kokai-Kun, John F., Scott M. Walsh, Tanya Chanturiya, and James J. Mond. "Lysostaphin Cream Eradicates Staphylococcus aureus Nasal Colonization in a Cotton Rat Model." Antimicrobial Agents and Chemotherapy 47, no. 5 (2003): 1589–97. http://dx.doi.org/10.1128/aac.47.5.1589-1597.2003.

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ABSTRACT The anterior nares are a primary ecologic niche for Staphylococcus aureus, and nasal colonization by this opportunistic pathogen increases the risk of development of S. aureus infection. Clearance of S. aureus nasal colonization greatly reduces this risk. Mupirocin ointment is the current standard of care for clearance of S. aureus nasal colonization, but resistance to this antibiotic is emerging. Lysostaphin is a glycylglycine endopeptidase which specifically cleaves the cross-linking pentaglycine bridges in the cell walls of staphylococci. Lysostaphin is extremely staphylocidal (MIC
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10

Heath, H. E., Lucie S. Heath, James D. Nitterauer, Karen E. Rose, and Gary L. Sloan. "Plasmid-encoded lysostaphin endopeptidase resistance of staphylococcussimulans biovar staphylolyticus." Biochemical and Biophysical Research Communications 160, no. 3 (1989): 1106–9. http://dx.doi.org/10.1016/s0006-291x(89)80117-2.

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Dissertations / Theses on the topic "Lysostaphin resistance"

1

Stumpf, Katrina S. "IS256 mediated alteration of femAB expression in Staphylococcus epidermidis and its effect on lysostaphin resistance." VCU Scholars Compass, 2007. http://scholarscompass.vcu.edu/etd_retro/59.

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Mechanisms responsible for the development of acquired resistance to lysostaphin, a glycylglycine endopeptidase, among isolates of Staphylococcus epidermidis were examined. Following overnight exposure to sub-inhibitory concentrations of lysostaphin, lysostaphin-resistant, oxacillin-susceptible mutants were isolated and characterized. Lysostaphin resistance was associated with mutations within the promoter region of the femAB operon. Four of the six characterized mutants contained an IS256 insertion within the femAB promoter and the remaining two mutants had an 18bp deletion within this regi
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Stumpf, Katrina Sue. "IS256 mediated alteration of femAB expression in staphylococcus epidermidis and its effect of lysostaphin resistance /." 2007. http://hdl.handle.net/10156/1183.

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