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Journal articles on the topic 'LysR-Type Transcriptional Regulator'

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Published: 2 June 2025
Last updated: 31 July 2025

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1

Xiao, Gaoping, Jianxin He, and Laurence G. Rahme. "Mutation analysis of the Pseudomonas aeruginosa mvfR and pqsABCDE gene promoters demonstrates complex quorum-sensing circuitry." Microbiology 152, no. 6 (2006): 1679–86. http://dx.doi.org/10.1099/mic.0.28605-0.

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The LysR-type transcriptional regulator MvfR (PqsR) (multiple virulence factor regulator) plays a critical role in Pseudomonas aeruginosa pathogenicity via the transcriptional regulation of multiple quorum-sensing (QS)-regulated virulence factors. LasR activates full mvfR transcription, and MvfR subsequently activates pqsA–E expression. This study identifies and characterizes the key cis-regulatory elements through which mvfR and pqsA–E transcription is regulated in the highly virulent P. aeruginosa strain PA14. Deletion and site-directed mutagenesis indicate that: (1) LasR activates mvfR tran
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2

Sperandio, Brice, Céline Gautier, Nicolas Pons, Dusko S. Ehrlich, Pierre Renault, and Eric Guédon. "Three Paralogous LysR-Type Transcriptional Regulators Control Sulfur Amino Acid Supply in Streptococcus mutans." Journal of Bacteriology 192, no. 13 (2010): 3464–73. http://dx.doi.org/10.1128/jb.00119-10.

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ABSTRACT The genome of Streptococcus mutans encodes 4 LysR-type transcriptional regulators (LTTRs), three of which, MetR, CysR (cysteine synthesis regulator), and HomR (homocysteine synthesis regulator), are phylogenetically related. MetR was previously shown to control methionine metabolic gene expression. Functional analysis of CysR and HomR was carried out by phenotypical studies and transcriptional analysis. CysR is required to activate the transcription of cysK encoding the cysteine biosynthesis enzyme, tcyABC and gshT genes encoding cysteine and glutathione transporter systems, and homR.
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3

Seynos-García, E., M. Castañeda-Lucio, J. Muñoz-Rojas, et al. "Loci identification of a N-acyl homoserine lactone type quorum sensing system and a new LysR-type transcriptional regulator associated with antimicrobial activity and swarming in Burkholderia gladioli UAPS07070." Open Life Sciences 14, no. 1 (2019): 165–78. http://dx.doi.org/10.1515/biol-2019-0019.

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AbstractA random transposition mutant library of B. gladioli UAPS07070 was analyzed for searching mutants with impaired microbial antagonism. Three derivates showed diminished antimicrobial activity against a sensitive strain. The mutated loci showed high similarity to the quorum sensing genes of the AHL-synthase and its regulator. Another mutant was affected in a gene coding for a LysrR-type transcriptional regulator. The production of toxoflavin, the most well known antimicrobial-molecule and a major virulence factor of plant-pathogenic B. glumae and B. gladioli was explored. The absence of
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4

Rashid, M. Mamunur, Yumi Ikawa, and Seiji Tsuge. "GamR, the LysR-Type Galactose Metabolism Regulator, RegulateshrpGene Expression via Transcriptional Activation of Two KeyhrpRegulators, HrpG and HrpX, in Xanthomonas oryzae pv. oryzae." Applied and Environmental Microbiology 82, no. 13 (2016): 3947–58. http://dx.doi.org/10.1128/aem.00513-16.

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ABSTRACTXanthomonas oryzaepv. oryzae is the causal agent of bacterial leaf blight of rice. For the virulence of the bacterium, thehrpgenes, encoding components of the type III secretion system, are indispensable. The expression ofhrpgenes is regulated by two keyhrpregulators, HrpG and HrpX: HrpG regulateshrpX, and HrpX regulates otherhrpgenes. Several other regulators have been shown to be involved in the regulation ofhrpgenes. Here, we found that a LysR-type transcriptional regulator that we named GamR, encoded byXOO_2767ofX. oryzaepv. oryzae strain MAFF311018, positively regulated the transc
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5

Guillouard, Isabelle, Sandrine Auger, Marie-Françoise Hullo, Farid Chetouani, Antoine Danchin, and Isabelle Martin-Verstraete. "Identification of Bacillus subtilis CysL, a Regulator of the cysJI Operon, Which Encodes Sulfite Reductase." Journal of Bacteriology 184, no. 17 (2002): 4681–89. http://dx.doi.org/10.1128/jb.184.17.4681-4689.2002.

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ABSTRACT The way in which the genes involved in cysteine biosynthesis are regulated is poorly characterized in Bacillus subtilis. We showed that CysL (formerly YwfK), a LysR-type transcriptional regulator, activates the transcription of the cysJI operon, which encodes sulfite reductase. We demonstrated that a cysL mutant and a cysJI mutant have similar phenotypes. Both are unable to grow using sulfate or sulfite as the sulfur source. The level of expression of the cysJI operon is higher in the presence of sulfate, sulfite, or thiosulfate than in the presence of cysteine. Conversely, the transc
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6

Luo, Li, Shi-Yi Yao, Anke Becker, et al. "Two New Sinorhizobium meliloti LysR-Type Transcriptional Regulators Required for Nodulation." Journal of Bacteriology 187, no. 13 (2005): 4562–72. http://dx.doi.org/10.1128/jb.187.13.4562-4572.2005.

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ABSTRACT The establishment of an effective nitrogen-fixing symbiosis between Sinorhizobium meliloti and its legume host alfalfa (Medicago sativa) depends on the timely expression of nodulation genes that are controlled by LysR-type regulators. Ninety putative genes coding for LysR-type transcriptional regulators were identified in the recently sequenced S. meliloti genome. All 90 putative lysR genes were mutagenized using plasmid insertions as a first step toward determining their roles in symbiosis. Two new LysR-type symbiosis regulator genes, lsrA and lsrB, were identified in the screening.
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7

Tumen-Velasquez, Melissa P., Nicole S. Laniohan, Cory Momany, and Ellen L. Neidle. "Engineering CatM, a LysR-Type Transcriptional Regulator, to Respond Synergistically to Two Effectors." Genes 10, no. 6 (2019): 421. http://dx.doi.org/10.3390/genes10060421.

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The simultaneous response of one transcriptional regulator to different effectors remains largely unexplored. Nevertheless, such interactions can substantially impact gene expression by rapidly integrating cellular signals and by expanding the range of transcriptional responses. In this study, similarities between paralogs were exploited to engineer novel responses in CatM, a regulator that controls benzoate degradation in Acinetobacter baylyi ADP1. One goal was to improve understanding of how its paralog, BenM, activates transcription in response to two compounds (cis,cis-muconate and benzoat
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8

Muraoka, S., R. Okumura, T. Nonaka, N. Ogawa, K. Miyashita, and T. Senda. "Crystal structure of CbnR, a LysR-type transcriptional regulator." Acta Crystallographica Section A Foundations of Crystallography 58, s1 (2002): c275. http://dx.doi.org/10.1107/s0108767302095971.

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9

Lochowska, Anna, Roksana Iwanicka-Nowicka, Danuta Plochocka, and Monika M. Hryniewicz. "Functional Dissection of the LysR-type CysB Transcriptional Regulator." Journal of Biological Chemistry 276, no. 3 (2000): 2098–107. http://dx.doi.org/10.1074/jbc.m007192200.

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10

Hernández-Lucas, I., A. L. Gallego-Hernández, S. Encarnación, et al. "The LysR-Type Transcriptional Regulator LeuO Controls Expression of Several Genes in Salmonella enterica Serovar Typhi." Journal of Bacteriology 190, no. 5 (2007): 1658–70. http://dx.doi.org/10.1128/jb.01649-07.

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ABSTRACT LeuO is a LysR-type transcriptional regulator that has been implicated in the bacterial stringent response and in the virulence of Salmonella. A genomic analysis with Salmonella enterica serovar Typhi revealed that LeuO is a positive regulator of OmpS1, OmpS2, AssT, and STY3070. In contrast, LeuO down-regulated the expression of OmpX, Tpx, and STY1978. Transcriptional fusions supported the positive and negative LeuO regulation. Expression of ompS1, assT, and STY3070 was induced in an hns mutant, consistent with the notion that H-NS represses these genes; transcriptional activity was l
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11

MacLean, Allyson M., Michelle I. Anstey, and Turlough M. Finan. "Binding Site Determinants for the LysR-Type Transcriptional Regulator PcaQ in the Legume Endosymbiont Sinorhizobium meliloti." Journal of Bacteriology 190, no. 4 (2007): 1237–46. http://dx.doi.org/10.1128/jb.01456-07.

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ABSTRACT LysR-type transcriptional regulators represent one of the largest groups of prokaryotic regulators described to date. In the gram-negative legume endosymbiont Sinorhizobium meliloti, enzymes involved in the protocatechuate branch of the β-ketoadipate pathway are encoded within the pcaDCHGB operon, which is subject to regulation by the LysR-type protein PcaQ. In this work, purified PcaQ was shown to bind strongly (equilibrium dissociation constant, 0.54 nM) to a region at positions −78 to −45 upstream of the pcaD transcriptional start site. Within this region, we defined a PcaQ binding
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12

Reen, F. Jerry, Matthieu Barret, Emilie Fargier, Marcus O’Muinneacháin, and Fergal O’Gara. "Molecular evolution of LysR-type transcriptional regulation in Pseudomonas aeruginosa." Molecular Phylogenetics and Evolution 66, no. 2013 (2012): 1041–4049. https://doi.org/10.1016/j.ympev.2012.12.014.

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 Signal perception and transduction through tightly coordinated circuits is integral to the survival and persistence of microbes in diverse ecological niches. The capacity to adapt to changes in the environment is central to their ability to thrive under adverse circumstances. Signal dependent transcriptional regulators are a key mechanism through which microbes assimilate environmental cues and mediate the appropriate adaptive response. By far the largest class of transcriptional regulator is the LysR-class, which is universally distributed among bacteria, archaea, and even eukaryotic or
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13

Jones, Rheinallt M., Bethan Britt-Compton, and Peter A. Williams. "The Naphthalene Catabolic (nag) Genes of Ralstonia sp. Strain U2 Are an Operon That Is Regulated by NagR, a LysR-Type Transcriptional Regulator." Journal of Bacteriology 185, no. 19 (2003): 5847–53. http://dx.doi.org/10.1128/jb.185.19.5847-5853.2003.

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ABSTRACT In Ralstonia sp. strain U2, the nag catabolic genes, which encode the enzymes for the pathway that catabolizes naphthalene via the alternative ring cleavage gentisate pathway, are transcribed as an operon under the same promoter. nagR, which encodes a LysR-type transcriptional regulator, is divergently transcribed compared to the nag catabolic genes. A 4-bp frameshift deletion in nagR demonstrated that NagR is required for expression of the nag operon. The transcriptional start of the nag operon was mapped, and a putative −10, −35 σ70-type promoter binding site was identified. Further
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14

Jovanovic, Milija, Mirjana Lilic, Dragutin J. Savic, and Goran Jovanovic. "The LysR-type transcriptional regulator CysB controls the repression of hslJ transcription in Escherichia coli." Microbiology 149, no. 12 (2003): 3449–59. http://dx.doi.org/10.1099/mic.0.26609-0.

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The LysR-type transcriptional regulator (LTTR) CysB is a transcription factor in Escherichia coli cells, where as a homotetramer it binds the target promoter regions and activates the genes involved in sulphur utilization and sulphonate-sulphur metabolism, while negatively autoregulating its own transcription. The hslJ gene was found to be negatively regulated by CysB and directly correlated with novobiocin resistance of the bacterium. cysB mutants showed upregulation of the hslJ : : lacZ gene fusion and exhibited increased novobiocin resistance. In this study the hslJ transcription start poin
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15

Martínez-Costa, Oscar H., Angel J. Martín-Triana, Eduardo Martínez, Miguel A. Fernández-Moreno, and Francisco Malpartida. "An Additional Regulatory Gene for Actinorhodin Production in Streptomyces lividans Involves a LysR-Type Transcriptional Regulator." Journal of Bacteriology 181, no. 14 (1999): 4353–64. http://dx.doi.org/10.1128/jb.181.14.4353-4364.1999.

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The sequence of a 4.8-kbp DNA fragment adjacent to the right-hand end of the actinorhodin biosynthetic (act) cluster downstream of actVB-orf6 from Streptomyces coelicolor A3(2) reveals six complete open reading frames, namedorf7 to orf12. The deduced amino acid sequences from orf7, orf10, and orf11 show significant similarities with the following products in the databases: a putative protein from the S. coelicolor SCP3 plasmid, LysR-type transcriptional regulators, and proteins belonging to the family of short-chain dehydrogenases/reductases, respectively. The deduced product of orf8 reveals l
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16

Chaudhari, Sujata S., Vinai C. Thomas, Marat R. Sadykov, et al. "The LysR-type transcriptional regulator, CidR, regulates stationary phase cell death inStaphylococcus aureus." Molecular Microbiology 101, no. 6 (2016): 942–53. http://dx.doi.org/10.1111/mmi.13433.

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17

Terazono, Koichi, Nobuhiro R. Hayashi, and Yasuo Igarashi. "CbbR, a LysR-type transcriptional regulator fromHydrogenophilus thermoluteolus, binds twocbbpromoter regions." FEMS Microbiology Letters 198, no. 2 (2001): 151–57. http://dx.doi.org/10.1111/j.1574-6968.2001.tb10635.x.

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18

Craven, Sarah H., Obidimma C. Ezezika, Sandra Haddad, Ruth A. Hall, Cory Momany, and Ellen L. Neidle. "Inducer responses of BenM, a LysR-type transcriptional regulator fromAcinetobacter baylyiADP1." Molecular Microbiology 72, no. 4 (2009): 881–94. http://dx.doi.org/10.1111/j.1365-2958.2009.06686.x.

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19

Yang, Xiaojing, Zhiqiang Zhang, Zhiwei Huang, et al. "A putative LysR-type transcriptional regulator inhibits biofilm synthesis inPseudomonas aeruginosa." Biofouling 35, no. 5 (2019): 541–50. http://dx.doi.org/10.1080/08927014.2019.1627337.

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20

Habdas, Benjamin J., Jennifer Smart, James B. Kaper, and Vanessa Sperandio. "The LysR-Type Transcriptional Regulator QseD Alters Type Three Secretion in Enterohemorrhagic Escherichia coli and Motility in K-12 Escherichia coli." Journal of Bacteriology 192, no. 14 (2010): 3699–712. http://dx.doi.org/10.1128/jb.00382-10.

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ABSTRACT Enterohemorrhagic Escherichia coli (EHEC) O157:H7 responds to the host-produced epinephrine and norepinephrine, and bacterially produced autoinducer 3 (AI-3), through two-component systems. Further integration of multiple regulatory signaling networks, involving regulators such as the LysR-type transcriptional regulator (LTTR) QseA, promotes effective regulation of virulence factors. These include the production of flagella, a phage-encoded Shiga toxin, and genes within the locus of enterocyte effacement (LEE) responsible for attaching and effacing (AE) lesion formation. Here, we desc
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21

Chugani, Sudha A., Matthew R. Parsek, and A. M. Chakrabarty. "Transcriptional Repression Mediated by LysR-Type Regulator CatR Bound at Multiple Binding Sites." Journal of Bacteriology 180, no. 9 (1998): 2367–72. http://dx.doi.org/10.1128/jb.180.9.2367-2372.1998.

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ABSTRACT The catBCA operon of Pseudomonas putidaencodes enzymes involved in the catabolism of benzoate. Transcription of this operon requires the LysR-type transcriptional regulator CatR and an inducer molecule, cis,cis-muconate. Previous gel shift assays and DNase I footprinting have demonstrated that CatR occupies two adjacent sites proximal to thecatBCA promoter in the presence of the inducer. We report the presence of an additional binding site for CatR downstream of thecatBCA promoter within the catB structural gene. This site, called the internal binding site (IBS), extends from +162 to
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22

Venkatesh, G. Raja, Frant Carlot Kembou Koungni, Andreas Paukner, Thomas Stratmann, Birgit Blissenbach, and Karin Schnetz. "BglJ-RcsB Heterodimers Relieve Repression of the Escherichia coli bgl Operon by H-NS." Journal of Bacteriology 192, no. 24 (2010): 6456–64. http://dx.doi.org/10.1128/jb.00807-10.

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ABSTRACT RcsB is the response regulator of the complex Rcs two-component system, which senses perturbations in the outer membrane and peptidoglycan layer. BglJ is a transcriptional regulator whose constitutive expression causes activation of the H-NS- and StpA-repressed bgl (aryl-β,d-glucoside) operon in Escherichia coli. RcsB and BglJ both belong to the LuxR-type family of transcriptional regulators with a characteristic C-terminal DNA-binding domain. Here, we show that BglJ and RcsB interact and form heterodimers that presumably bind upstream of the bgl promoter, as suggested by mutation of
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23

Kalyuzhnaya, Marina G., and Mary E. Lidstrom. "QscR, a LysR-Type Transcriptional Regulator and CbbR Homolog, Is Involved in Regulation of the Serine Cycle Genes in Methylobacterium extorquens AM1." Journal of Bacteriology 185, no. 4 (2003): 1229–35. http://dx.doi.org/10.1128/jb.185.4.1229-1235.2003.

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ABSTRACT A new gene, qscR, encoding a LysR-type transcriptional regulator that is a homolog of CbbR, has been characterized from the facultative methylotroph Methylobacterium extorquens AM1 and shown to be the major regulator of the serine cycle, the specific C1 assimilation pathway. The qscR mutant was shown to be unable to grow on C1 compounds, and it lacked the activity of serine-glyoxylate aminotransferase, a key enzyme of the serine cycle. Activities of other serine cycle enzymes were decreased during growth on C1 compounds compared to the activities found in wild-type M. extorquens AM1.
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24

Lu, Hsu-Feng, Yu-Chieh Tsai, Li-Hua Li, Yi-Tsung Lin, and Tsuey-Ching Yang. "Role of AzoR, a LysR-type transcriptional regulator, in SmeVWX pump-mediated antibiotic resistance in Stenotrophomonas maltophilia." Journal of Antimicrobial Chemotherapy 76, no. 9 (2021): 2285–93. http://dx.doi.org/10.1093/jac/dkab203.

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Abstract Background The SmeVWX efflux pump of Stenotrophomonas maltophilia contributes to menadione (MD) tolerance and resistance to chloramphenicol, quinolones and tetracycline. The components of the SmeVWX efflux pump are encoded by a five-gene operon, smeU1VWU2X. We have previously demonstrated that the smeU1VWU2X operon is intrinsically unexpressed and inducibly expressed by MD via a SoxR- and SmeRv-involved regulatory circuit in S. maltophilia KJ. We also inferred that there should be other regulator(s) involved in MD-mediated smeU1VWU2X expression in addition to SoxR and SmeRv. Objective
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25

Verschueren, Koen H. G., Christine Addy, Eleanor J. Dodson, and Anthony J. Wilkinson. "Crystallization of full-length CysB ofKlebsiella aerogenes, a LysR-type transcriptional regulator." Acta Crystallographica Section D Biological Crystallography 57, no. 2 (2001): 260–62. http://dx.doi.org/10.1107/s0907444900016851.

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26

Maddocks, Sarah E., and Petra C. F. Oyston. "Structure and function of the LysR-type transcriptional regulator (LTTR) family proteins." Microbiology 154, no. 12 (2008): 3609–23. http://dx.doi.org/10.1099/mic.0.2008/022772-0.

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27

Mao, Dainan, Leah B. Bushin, Kyuho Moon, Yihan Wu, and Mohammad R. Seyedsayamdost. "Discovery ofscmRas a global regulator of secondary metabolism and virulence inBurkholderia thailandensisE264." Proceedings of the National Academy of Sciences 114, no. 14 (2017): E2920—E2928. http://dx.doi.org/10.1073/pnas.1619529114.

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Bacteria produce a diverse array of secondary metabolites that have been invaluable in the clinic and in research. These metabolites are synthesized by dedicated biosynthetic gene clusters (BGCs), which assemble architecturally complex molecules from simple building blocks. The majority of BGCs in a given bacterium are not expressed under normal laboratory growth conditions, and our understanding of how they are silenced is in its infancy. Here, we have addressed this question in the Gram-negative model bacteriumBurkholderia thailandensisE264 using genetic, transcriptomic, metabolomic, and che
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28

Braz, Vânia S., José F. da Silva Neto, Valéria C. S. Italiani, and Marilis V. Marques. "CztR, a LysR-Type Transcriptional Regulator Involved in Zinc Homeostasis and Oxidative Stress Defense in Caulobacter crescentus." Journal of Bacteriology 192, no. 20 (2010): 5480–88. http://dx.doi.org/10.1128/jb.00496-10.

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ABSTRACT Caulobacter crescentus is a free-living alphaproteobacterium that has 11 predicted LysR-type transcriptional regulators (LTTRs). Previously, a C. crescentus mutant strain with a mini-Tn5lacZ transposon inserted into a gene encoding an LTTR was isolated; this mutant was sensitive to cadmium. In this work, a mutant strain with a deletion was obtained, and the role of this LTTR (called CztR here) was evaluated. The transcriptional start site of this gene was determined by primer extension analysis, and its promoter was cloned in front of a lacZ reporter gene. β-Galactosidase activity ass
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29

Richards, Gregory R., Erin E. Herbert, Youngjin Park, and Heidi Goodrich-Blair. "Xenorhabdus nematophila lrhA Is Necessary for Motility, Lipase Activity, Toxin Expression, and Virulence in Manduca sexta Insects." Journal of Bacteriology 190, no. 14 (2008): 4870–79. http://dx.doi.org/10.1128/jb.00358-08.

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ABSTRACT The gram-negative insect pathogen Xenorhabdus nematophila possesses potential virulence factors including an assortment of toxins, degradative enzymes, and regulators of these compounds. Here, we describe the lysR-like homolog A (lrhA) gene, a gene required by X. nematophila for full virulence in Manduca sexta insects. In several other gram-negative bacteria, LrhA homologs are transcriptional regulators involved in the expression (typically repression) of virulence factors. Based on phenotypic and genetic evidence, we report that X. nematophila LrhA has a positive effect on transcript
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30

Fragel, Susann M., Anna Montada, Ralf Heermann, Ulrich Baumann, Magdalena Schacherl, and Karin Schnetz. "Characterization of the pleiotropic LysR-type transcription regulator LeuO of Escherichia coli." Nucleic Acids Research 47, no. 14 (2019): 7363–79. http://dx.doi.org/10.1093/nar/gkz506.

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AbstractLeuO is a pleiotropic LysR-type transcriptional regulator (LTTR) and co-regulator of the abundant nucleoid-associated repressor protein H-NS in Gammaproteobacteria. As other LTTRs, LeuO is a tetramer that is formed by dimerization of the N-terminal DNA-binding domain (DBD) and C-terminal effector-binding domain (EBD). To characterize the Escherichia coli LeuO protein, we screened for LeuO mutants that activate the cas (CRISPR-associated/Cascade) promoter more effectively than wild-type LeuO. This yielded nine mutants carrying amino acid substitutions in the dimerization interface of th
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31

Bender, Robert A. "A NAC for Regulating Metabolism: the Nitrogen Assimilation Control Protein (NAC) from Klebsiella pneumoniae." Journal of Bacteriology 192, no. 19 (2010): 4801–11. http://dx.doi.org/10.1128/jb.00266-10.

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ABSTRACT The nitrogen assimilation control protein (NAC) is a LysR-type transcriptional regulator (LTTR) that is made under conditions of nitrogen-limited growth. NAC's synthesis is entirely dependent on phosphorylated NtrC from the two-component Ntr system and requires the unusual sigma factor σ54 for transcription of the nac gene. NAC activates the transcription of σ70-dependent genes whose products provide the cell with ammonia or glutamate. NAC represses genes whose products use ammonia and also represses its own transcription. In addition, NAC also subtly adjusts other cellular functions
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32

Yang, Soo-Jin, Kelly C. Rice, Raquel J. Brown, et al. "A LysR-Type Regulator, CidR, Is Required for Induction of the Staphylococcus aureus cidABC Operon." Journal of Bacteriology 187, no. 17 (2005): 5893–900. http://dx.doi.org/10.1128/jb.187.17.5893-5900.2005.

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ABSTRACT The Staphylococcus aureus cidABC and lrgAB operons have been shown to regulate murein hydrolase activity and affect antibiotic tolerance. The cid operon enhances murein hydrolase activity and antibiotic sensitivity, whereas the lrg operon inhibits these processes. Based on these findings and the structural similarities of the cidA and lrgA gene products to the bacteriophage holin family of proteins, we have proposed that the cid and lrg operons encode holin- and antiholin-like proteins, respectively, that function to control the murein hydrolase activity produced by the bacteria. Anal
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33

Bernier, Steve P., David T. Nguyen, and Pamela A. Sokol. "A LysR-Type Transcriptional Regulator in Burkholderia cenocepacia Influences Colony Morphology and Virulence." Infection and Immunity 76, no. 1 (2007): 38–47. http://dx.doi.org/10.1128/iai.00874-07.

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ABSTRACT Burkholderia cenocepacia strain K56-2 typically has rough colony morphology on agar medium; however, shiny colony variants (shv) can appear spontaneously. These shv all had a minimum of 50% reduction in biomass formation and were generally avirulent in an alfalfa seedling infection model. Three shv—K56-2 S15, K56-2 S76, and K56-2 S86—were analyzed for virulence in a chronic agar bead model of respiratory infection and, although all shv were able to establish chronic infection, they produced significantly less lung histopathology than the rough K56-2. Transmission electron microscopy r
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34

Pande, Santosh G., Fernando A. Pagliai, Christopher L. Gardner, et al. "Lactobacillus brevis responds to flavonoids through KaeR, a LysR-type of transcriptional regulator." Molecular Microbiology 81, no. 6 (2011): 1623–39. http://dx.doi.org/10.1111/j.1365-2958.2011.07796.x.

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35

Huang, Jianzhong, Wandee Yindeeyoungyeon, Ram P. Garg, Timothy P. Denny, and Mark A. Schell. "Joint Transcriptional Control of xpsR, the Unusual Signal Integrator of the Ralstonia solanacearum Virulence Gene Regulatory Network, by a Response Regulator and a LysR-Type Transcriptional Activator." Journal of Bacteriology 180, no. 10 (1998): 2736–43. http://dx.doi.org/10.1128/jb.180.10.2736-2743.1998.

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ABSTRACT Ralstonia (Pseudomonas)solanacearum is a soil-borne phytopathogen that causes a wilting disease of many important crops. It makes large amounts of the exopolysaccharide EPS I, which it requires for efficient colonization, wilting, and killing of plants. Transcription of the epsoperon, encoding biosynthetic enzymes for EPS I, is controlled by a unique and complex sensory network that responds to multiple environmental signals. This network is comprised of the novel transcriptional activator XpsR, three distinct two-component regulatory systems (VsrAD, VsrBC, and PhcSR), and the LysR-ty
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36

Liao, Chun-Hsing, Wei-Chien Chen, Li-Hua Li, Yi-Tsung Lin, Sz-Yun Pan та Tsuey-Ching Yang. "AmpR of Stenotrophomonas maltophilia is involved in stenobactin synthesis and enhanced β-lactam resistance in an iron-depleted condition". Journal of Antimicrobial Chemotherapy 75, № 12 (2020): 3544–51. http://dx.doi.org/10.1093/jac/dkaa358.

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Abstract Background Iron is an essential nutrient for almost all aerobic organisms, including Stenotrophomonas maltophilia. Fur is the only known transcriptional regulator presumptively involved in iron homeostasis in S. maltophilia. AmpR, a LysR-type transcriptional regulator, is known to regulate β-lactamase expression and β-lactam resistance in S. maltophilia. Objectives To identify the novel regulator involved in controlling the viability of S. maltophilia in an iron-depleted condition and to elucidate the underlying regulatory mechanisms. Methods The potential regulator involved in iron h
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37

Yamamoto, Kanon, Takashi Fujikawa, Ayaka Uke, Giyu Usuki, Yasuhiro Ishiga, and Nanami Sakata. "LysR-Type Transcriptional Regulator Contributes to Pseudomonas cannabina pv. alisalensis Virulence by Regulating Type Three Secretion System." Bacteria 3, no. 4 (2024): 499–512. https://doi.org/10.3390/bacteria3040033.

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Pseudomonas cannabina pv. alisalensis (Pcal) causes bacterial blight on cabbage. In a previous study, we screened for reduced virulence using Tn5 transposon mutants and identified a LysR-type transcriptional regulator (LTTR) as a potential virulence factor in Pcal. However, the role of LTTR in Pcal virulence has not been thoroughly investigated. In this study, we demonstrated that the Pcal NN14 mutant (with Tn5 insertion in the LTTR-encoding gene) showed reduced disease symptoms and bacterial populations in cabbage, indicating that LTTR contributes to Pcal virulence. RNA-seq analysis identifie
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38

Maeda, Shin-Ichi, Yuriko Kawaguchi, Taka-Aki Ohe, and Tatsuo Omata. "cis-Acting Sequences Required for NtcB-Dependent, Nitrite-Responsive Positive Regulation of the Nitrate Assimilation Operon in the Cyanobacterium Synechococcus sp. Strain PCC 7942." Journal of Bacteriology 180, no. 16 (1998): 4080–88. http://dx.doi.org/10.1128/jb.180.16.4080-4088.1998.

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ABSTRACT There are three binding sites for NtcA (nirI,nirII, and nirIII), the global nitrogen regulator of cyanobacteria, in the DNA region between the two divergently transcribed operons (nirA andnirB operons) involved in nitrate assimilation inSynechococcus sp. strain PCC 7942. Using theluxAB reporter system, we showed that nirI andnirIII, which are located 23 bp upstream from the −10 promoter element of nirA and nirB, respectively, are required for induction by nitrogen depletion of thenirA and nirB operons, respectively. The induction of nirA operon transcription was a prerequisite for the
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39

Platero, Ana Isabel, Manuel García-Jaramillo, Eduardo Santero, and Fernando Govantes. "Transcriptional Organization and Regulatory Elements of a Pseudomonas sp. Strain ADP Operon Encoding a LysR-Type Regulator and a Putative Solute Transport System." Journal of Bacteriology 194, no. 23 (2012): 6560–73. http://dx.doi.org/10.1128/jb.01348-12.

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ABSTRACTTheatzS-atzT-atzU-atzV-atzWgene cluster of thePseudomonassp. strain ADP atrazine-degradative plasmid pADP-1, which carries genes for an outer membrane protein and the components of a putative ABC-type solute transporter, is located downstream fromatzR, which encodes the LysR-type transcriptional regulator of the cyanuric acid-degradative operonatzDEF. Here we describe the transcriptional organization of these genes. Our results show that all six genes are cotranscribed from the PatzRpromoter to form theatzRSTUVWoperon. A second, stronger promoter, PatzT, is found withinatzSand directs
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40

Köhler, Thilo, Simone F. Epp, Lasta Kocjancic Curty, and Jean-Claude Pechère. "Characterization of MexT, the Regulator of the MexE-MexF-OprN Multidrug Efflux System of Pseudomonas aeruginosa." Journal of Bacteriology 181, no. 20 (1999): 6300–6305. http://dx.doi.org/10.1128/jb.181.20.6300-6305.1999.

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ABSTRACT We investigated the regulation of the MexEF-OprN multidrug efflux system of Pseudomonas aeruginosa, which is overexpressed innfxC-type mutants and confers resistance to quinolones, chloramphenicol and trimethoprim. Sequencing of the DNA region upstream of the mexEF-oprN operon revealed the presence of an open reading frame (ORF) of 304 amino acids encoding a LysR-type transcriptional activator, termed MexT. By using T7-polymerase, a 34-kDa protein was expressed in Escherichia coli from a plasmid carrying the mexT gene. Expression of amexE::lacZ fusion was 10-fold higher in nfxC-type m
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41

van Keulen, Geertje, Anja N. J. A. Ridder, Lubbert Dijkhuizen, and Wim G. Meijer. "Analysis of DNA Binding and Transcriptional Activation by the LysR-Type Transcriptional Regulator CbbR of Xanthobacter flavus." Journal of Bacteriology 185, no. 4 (2003): 1245–52. http://dx.doi.org/10.1128/jb.185.4.1245-1252.2003.

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ABSTRACT The LysR-type transcriptional regulator CbbR controls the expression of the cbb and gap-pgk operons in Xanthobacter flavus, which encode the majority of the enzymes of the Calvin cycle required for autotrophic CO2 fixation. The cbb operon promoter of this chemoautotrophic bacterium contains three potential CbbR binding sites, two of which partially overlap. Site-directed mutagenesis and subsequent analysis of DNA binding by CbbR and cbb promoter activity were used to show that the potential CbbR binding sequences are functional. Inverted repeat IR1 is a high-affinity CbbR binding site
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42

Wang, Qian, Yi Wei, Yu Huang, et al. "Z3495, a LysR-Type Transcriptional Regulator Encoded in O Island 97, Regulates Virulence Gene Expression in Enterohemorrhagic Escherichia coli O157:H7." Microorganisms 12, no. 1 (2024): 140. http://dx.doi.org/10.3390/microorganisms12010140.

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Enterohemorrhagic Escherichia coli (EHEC) is an important foodborne pathogen that infects humans by colonizing the large intestine. The genome of EHEC O157:H7 contains 177 unique O islands (OIs). Certain OIs significantly contribute to the heightened virulence and pathogenicity exhibited by EHEC O157:H7. However, the function of most OI genes remains unknown. We demonstrated here that EHEC O157:H7 adherence to and colonization of the mouse large intestine are both dependent on OI-97. Z3495, which is annotated as a LysR-type transcriptional regulator and encoded in OI-97, contributes to this ph
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43

Jo, Inseong, Dajeong Kim, Taehoon No, et al. "Structural basis for HOCl recognition and regulation mechanisms of HypT, a hypochlorite-specific transcriptional regulator." Proceedings of the National Academy of Sciences 116, no. 9 (2019): 3740–45. http://dx.doi.org/10.1073/pnas.1811509116.

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Hypochlorous acid (HOCl) is generated in the immune system to kill microorganisms. In Escherichia coli, a hypochlorite-specific transcription regulator, HypT, has been characterized. HypT belongs to the LysR-type transcriptional regulator (LTTR) family that contains a DNA-binding domain (DBD) and a regulatory domain (RD). Here, we identified a hypT gene from Salmonella enterica serovar Typhimurium and determined crystal structures of the full-length HypT protein and the RD. The full-length structure reveals a type of tetrameric assembly in the LTTR family. Based on HOCl-bound and oxidation-mim
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44

Muraoka, Shin, Rumi Okumura, Yoshitaka Uragami, et al. "Purification and Crystallization of a Lysr-Type Transcriptional Regulator Cbnr from Ralstonia Eutropha Nh9." Protein & Peptide Letters 10, no. 3 (2003): 325–29. http://dx.doi.org/10.2174/0929866033478942.

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45

Ezezika, Obidimma C., Sandra Haddad, Todd J. Clark, Ellen L. Neidle, and Cory Momany. "Distinct Effector-binding Sites Enable Synergistic Transcriptional Activation by BenM, a LysR-type Regulator." Journal of Molecular Biology 367, no. 3 (2007): 616–29. http://dx.doi.org/10.1016/j.jmb.2006.09.090.

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46

Gong, Wenjie, Guangming Xiong, and Edmund Maser. "Oligomerization and negative autoregulation of the LysR-type transcriptional regulator HsdR from Comamonas testosteroni." Journal of Steroid Biochemistry and Molecular Biology 132, no. 3-5 (2012): 203–11. http://dx.doi.org/10.1016/j.jsbmb.2012.05.012.

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47

Colombo, Victoria, Francisco Malpartida, and Maria Fernández-de-Heredia. "A polyketide biosynthetic gene cluster from Streptomyces antibioticus includes a LysR-type transcriptional regulator." Microbiology 147, no. 11 (2001): 3083–92. http://dx.doi.org/10.1099/00221287-147-11-3083.

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48

Smart, James L., and Carl E. Bauer. "Tetrapyrrole Biosynthesis in Rhodobacter capsulatus Is Transcriptionally Regulated by the Heme-Binding Regulatory Protein, HbrL." Journal of Bacteriology 188, no. 4 (2006): 1567–76. http://dx.doi.org/10.1128/jb.188.4.1567-1576.2006.

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ABSTRACT We demonstrate that the expression of hem genes in Rhodobacter capsulatus is transcriptionally repressed in response to the exogenous addition of heme. A high-copy suppressor screen for regulators of hem gene expression resulted in the identification of an LysR-type transcriptional regulator, called HbrL, that regulates hem promoters in response to the availability of heme. HbrL is shown to activate the expression of hemA and hemZ in the absence of exogenous hemin and repress hemB expression in the presence of exogenous hemin. Heterologously expressed HbrL apoprotein binds heme b and
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49

McCarthy, Ronan R., Marlies J. Mooij, F. Jerry Reen, Olivier Lesouhaitier, and Fergal O’Gara. "A new regulator of pathogenicity (bvlR) is required for full virulence and tight microcolony formation in Pseudomonas aeruginosa." Microbiology 160, no. 7 (2014): 1488–500. http://dx.doi.org/10.1099/mic.0.075291-0.

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LysR-type transcriptional regulators (LTTRs) are the most common family of transcriptional regulators found in the opportunistic pathogen Pseudomonas aeruginosa. They are known to regulate a wide variety of virulence determinants and have emerged recently as positive global regulators of pathogenicity in a broad spectrum of important bacterial pathogens. However, in spite of their key role in modulating expression of key virulence determinants underpinning pathogenic traits associated with the process of infection, surprisingly few are found to be transcriptionally altered by contact with host
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50

Wade, Dana S., M. Worth Calfee, Edson R. Rocha, et al. "Regulation of Pseudomonas Quinolone Signal Synthesis in Pseudomonas aeruginosa." Journal of Bacteriology 187, no. 13 (2005): 4372–80. http://dx.doi.org/10.1128/jb.187.13.4372-4380.2005.

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ABSTRACT Pseudomonas aeruginosa is an opportunistic pathogen that causes chronic lung infections in cystic fibrosis patients and is a major source of nosocomial infections. This bacterium controls many virulence factors by using two quorum-sensing systems, las and rhl. The las system is composed of the LasR regulator protein and its cell-to-cell signal, N-(3-oxododecanoyl) homoserine lactone, and the rhl system is composed of RhlR and the signal N-butyryl homoserine lactone. A third intercellular signal, the Pseudomonas quinolone signal (PQS; 2-heptyl-3-hydroxy-4-quinolone), also regulates num
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