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Journal articles on the topic 'Lytic Bone Lesions'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Anil, Kumar, Kumar Manoj, and Mishra Asim. "To Assess the Significance of Histopathology in the Diagnostic Process of Lytic Bone Lesions at a Tertiary Centre." International Journal of Pharmaceutical and Clinical Research 15, no. 10 (2023): 1340–47. https://doi.org/10.5281/zenodo.11294619.

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<strong>Background:</strong> The presence of lytic bone lesions is a common radiographic finding seen in patients seeking orthopaedic care. The histopathology’s plays a crucial role in providing guidance to orthopaedic surgeons in the management of patients with lytic lesions. <strong>Aims and Objectives:</strong> The purpose of this study is to assess the significance of histopathology in the diagnostic process of lytic bone lesions. <strong>Materials and Methods: </strong>The selection criteria for patients included those with radiologically evident bone diseas

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2

Haque, Salina, Zulfia Zinat Chowdhury, Kazi Ishraque Ahmed, et al. "Spectrum of Bone Complications in Newly diagnosed Multiple Myeloma patients." Haematology Journal of Bangladesh 6, no. 02 (2022): 08–12. http://dx.doi.org/10.37545/haematoljbd202290.

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Abstract Multiple myeloma is a malignant disorder of plasma cells that seed throughout the bone marrow and usually produce a monoclonal immunoglobulin in the blood, urine, or both, cause lytic bone lesions. A total of 159 newly diagnosed multiple myeloma patients aged 24 to 85 were included in this study. The median age of 159 patients was 56 years. Highest incidence of multiple myeloma was found in 50-59 years age group and P value was statistically significant. Male patient was 103 (65%) and female patient was 56 (35%). The median age of male patients was 56 years and the female patien

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Mendes, Gabriela Ribas, Fernando Swiech Bach, Luiz Fernando Cardoso Garcia, Saulo Henrique Weber, and José Ademar Villanova Junior. "A retrospective study of dogs with vertebral lytic lesions diagnosed tomografically: 28 cases (2012-2017)." Semina: Ciências Agrárias 40, no. 5Supl1 (2019): 2223. http://dx.doi.org/10.5433/1679-0359.2019v40n5supl1p2223.

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Lytic vertebral lesions cause significant pain and variable neurological deficits can cause sensory, motor and proprioceptive loss, and are causes of bones lysis such as discospondylitis, vertebral tumors, bone cysts and osteomyelitis. This study aimed to investigate the prevalence of vertebral lytic lesions in the canine population, from computed tomographic (CT) image analyses. A retrospective study, based on the descriptive findings from simple and contrast enhanced CT scans of dogs, between the years 2012 to 2017, was performed. The study consisted of the sequential analysis of 371 reports

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4

Khurana, Jasvir S., Shuji Ogino, Ting Shen, et al. "Bone Morphogenetic Proteins Are Expressed by Both Bone-Forming and Non–Bone-Forming Lesions." Archives of Pathology & Laboratory Medicine 128, no. 11 (2004): 1267–69. http://dx.doi.org/10.5858/2004-128-1267-bmpaeb.

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Abstract Context.—Bone morphogenetic proteins (BMPs) are thought to be responsible for bone formation; they cause bone to form in soft tissues and are clinically used in helping fracture union or tumor reconstructions. Skeletal metastases from epithelial tumors may be either bone-forming (blastic) or non–bone-forming (lytic). Objective.—We studied the expression of BMPs in a variety of primary and secondary lesions of bone (both bone-forming and non–bone-forming) to determine if there was a consistent relationship between bone formation and BMP expression. Design.—We compared a bone-forming le

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Sreenivas, Kalyan Deepak, Sathyanarayanan Parthasarathy, and Akashdeep Ambikakumari Ajayakumar. "A Lytic Lesion in Proximal Phalanx of Hand: A Case Report and Diagnostic Approach." Case Reports in Orthopedic Research 4, no. 2 (2021): 145–51. http://dx.doi.org/10.1159/000516253.

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Lytic lesions arising in the hand can be confused with an enchondroma. Enchondroma is the most common tumor of the hand and can present with varied features. It often requires only observation. A dilemma arises when surgically treatable lesions like aneurysmal bone cyst (ABC) present in uncommon locations like the hand. To diagnose a lytic lesion in the hand, percutaneous biopsy is commonly done. But, percutaneous biopsy is unnecessary in enchondroma and may not be useful in conditions like simple bone cyst and ABC. In such situations, magnetic resonance imaging (MRI) can differentiate between

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Pandey, Vivek, Vishnu Senthil, and Kiran Acharya. "Rare Lytic Lesions of the Talus: A Diagnostic Challenge." Journal of Foot and Ankle Surgery (Asia Pacific) 4, no. 1 (2017): 49–52. http://dx.doi.org/10.5005/jp-journals-10040-1070.

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ABSTRACT Patients presenting with prolonged ankle pain following trivial trauma should be clinically and radiologically investigated. We present two young adults with incidentally diagnosed lytic lesion of talus. They underwent extended curettage and biopsy. Histopathological examination proved as aneurysmal and simple bone cyst and went for a secondary procedure of bone grafting. We want to emphasize the importance of differential diagnosis in the management of lytic lesions and complete removal of tumor. How to cite this article Senthil V, Pandey V, Acharya K. Rare Lytic Lesions of the Talus

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Battikh, Naim G., Elrazi Awadelkarim Awadelkarim Hamid Ali, and Mohamed A. Yassin. "Osteolytic Bone Lesions in Patients with Primary Myelofibrosis: A Systematic Review." Blood 138, Supplement 1 (2021): 4624. http://dx.doi.org/10.1182/blood-2021-144449.

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Abstract Background: Philadelphia negative Myeloproliferative neoplasms classically characterized by excess production of terminal myeloid cells in the peripheral blood. Among this group, primary myelofibrosis is the least common and usually carries the worst prognosis. Bone involvement in primary myelofibrosis has many forms and tend to manifest as osteosclerotic lesions in vast majority of cases, however osteolytic lesions are reported in exceptional occasions. In this review, we tried to shed the light on this rare association. Methods: We performed a systematic review following the Preferr

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GAFFNEY, Elizabeth K., and Gregory SUMMERS. "Non-malignant lytic lesions of bone." International Journal of Rheumatic Diseases 15, no. 1 (2011): e10-e11. http://dx.doi.org/10.1111/j.1756-185x.2011.01667.x.

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9

Fallon, Keelin, Ali Akalin, Peggy Wu, and Aaron K. Remenschneider. "Primary Sarcoidosis of the Temporal Bone a Clinical Pathologic Correlation." Otology & Neurotology Open 3, no. 3 (2023): e039. http://dx.doi.org/10.1097/ono.0000000000000039.

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Objective: This report describes a case of sarcoidosis that presented as a lytic bone lesion in the squamous part of the temporal bone. Patients: A 64-year-old woman presented with right-sided aural fullness, pulsatile tinnitus, and intermittent otalgia. Interventions: CT and MRI were performed without contrast and suggested an osseodestructive, lytic bone lesion. An excisional biopsy was performed, showing granulomatous infiltration suggestive of osseous sarcoidosis. Main Outcome Measures: Removal of mass and resolution of symptoms. Results: Initial findings from patient imaging suggested a l

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Finkelstein, Samuel, Srinivas Raman, Joanne Van Der Velden, et al. "Changes in Volume and Density Parameters Measured on Computed Tomography Images Following Stereotactic Body Radiation Therapy of Nonspine Bone Metastases." Technology in Cancer Research & Treatment 18 (January 1, 2019): 153303381985353. http://dx.doi.org/10.1177/1533033819853532.

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Introduction: Volumetric and density parameters measured from computed tomography scans were investigated for evaluating treatment response of nonspine bone lesions following stereotactic body radiation therapy. Methods: Twenty-three patients treated with stereotactic body radiation therapy to nonspine bone metastases with pre- and post-treatment radiological follow-up with computed tomography imaging were identified in a retrospective review. An expert radiologist classified 26 lesions by type (lytic, sclerotic) and by response. Two independent radiation oncologists created separate contours

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TURGUTKAYA, Atakan, İrfan YAVAŞ, Tuğba ŞAHİN, Gokhan SARGIN, Gürhan KADIKÖYLÜ, and Ali BOLAMAN. "INVESTIGATION OF THE RADIOLOGICAL TECHNIQUES TO DETECT OSTEOLYTIC LESIONS, FRACTURES, AND OSTEOPOROSIS IN MULTIPLE MYELOMA PATIENTS." Ege Tıp Dergisi 62, no. 4 (2023): 536–41. http://dx.doi.org/10.19161/etd.1147765.

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Aim: Multiple myeloma is a malignancy of clonal plasmacytes. Osteolytic lesions represent a criterion for symptomatic myeloma and are associated with bone loss, pathological fractures, and osteoporosis. Skeletal surveys with other sophisticated techniques and dual-energy x-ray absorptiometry (DEXA) are used to screen lytic lesions, and bone mineral loss, respectively. Here, we aimed to investigate the rates of detection regarding osteolytic lesions and bone mineral loss by several imaging techniques. Materials and Methods: The study was carried out in Adnan Menderes University Hospital/T

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Muehlschlegel, Paula, Roopinder Gillmore, and Sabine Pomplun. "Metastatic breast cancer and monoclonal gammopathy of undetermined significance resembling multiple myeloma." BMJ Case Reports 16, no. 6 (2023): e254016. http://dx.doi.org/10.1136/bcr-2022-254016.

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Radiological evidence of lytic bone lesions has a wide differential diagnosis including metastatic bone disease, multiple myeloma, primary bone cancers and infection. Here, we present the case of a woman in her 80s found to have lytic bone lesions associated with an IgA paraproteinaemia who was thus presumed to have a diagnosis of multiple myeloma. However, bone marrow biopsy results were indicative of monoclonal gammopathy of undetermined significance. She was subsequently referred to the ‘carcinoma of unknown primary (CUP) team’, and ultimately diagnosed with metastatic breast cancer followi

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A.H, Chidiebere, and Songden Z.D. "Parathyroid Adenoma Presenting with Multiple Long Bone Lytic Lesions in An Adult Female: A Diagnostic Dilemma." SVOA Orthopaedics 4, no. 4 (2024): 67–72. http://dx.doi.org/10.58624/svoaor.2024.04.073.

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Lytic bone lesion is one of the manifestations of Parathyroid adenoma due to osteoclastic bone resorption. It is also referred to as Brown's tumor and it is characterized by elevated serum calcium and serum parathyroid hormone. Primary hyperparathyroidism is due to parathyroid adenoma in 80-85% of cases, hyperplasia in 10-15% of cases and carcinoma in 1-5% of cases. Our case is a 38year old female with multiple long bone lytic lesions resembling malignancies for which the primary source could not be identified from the clinical examination. A possible diagnosis of primary and secondary bone ma

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AN, JASON W., and SARAH M. TROSTER. "Lytic Bone Lesions: Osteomyelitis or Intraosseous Gout?" Journal of Rheumatology 44, no. 9 (2017): 1410–11. http://dx.doi.org/10.3899/jrheum.170125.

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15

Jacobs, Peter, Lucille Wood, and Hillel Goodman. "Lytic bone lesions in polycythaemia rubra vera." European Journal of Haematology 45, no. 5 (2009): 275–77. http://dx.doi.org/10.1111/j.1600-0609.1990.tb00476.x.

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Colley, Steven, and Karl Johnson. "Systemic hyalinosis with extensive lytic bone lesions." Pediatric Radiology 36, no. 9 (2006): 998. http://dx.doi.org/10.1007/s00247-006-0196-0.

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Sidhu, Gurinder, and Yamen Homsi. "Severe Lytic Bone Lesions in Multiple Myeloma." American Journal of the Medical Sciences 357, no. 4 (2019): e11-e12. http://dx.doi.org/10.1016/j.amjms.2018.12.006.

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18

Sacré, K., C. Aguilar, C. Deligny, et al. "Lytic bone lesions in lupus-associated myelofibrosis." Lupus 19, no. 3 (2009): 313–16. http://dx.doi.org/10.1177/0961203309349118.

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19

Sofman, Michael S., and Neil S. Prose. "Dermatoses associated with sterile lytic bone lesions." Journal of the American Academy of Dermatology 23, no. 3 (1990): 494–98. http://dx.doi.org/10.1016/0190-9622(90)70248-g.

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20

Jajeh, Ahmad. "Plasmacytoid Transformation of Chronic Lymphocytic Leukemia CLL with Multiple Lytic Bony Lesions." Blood 120, no. 21 (2012): 4590. http://dx.doi.org/10.1182/blood.v120.21.4590.4590.

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Abstract Abstract 4590 Richter transformattion in patients with Chronic Lymphocytic Leukemia CLL can happen in 3%- 15%. This involve transformation of relatively indolent CLL cells into higher grade and aggressive form of Lymphoma. Plasmcytoid transformation of CLL with paraprotinemia, multiple lytic lesions and hypercalcemia can occur. This abstract will describe six patients with CLL who presented with hypercalcemia and lytic bony lesions in the course of their disease. Mean age is 72 years old. All were males, four whites and two blacks. One patient had solitary bony lesion with solitary sm

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21

Hiremath, Rudresh, and Abhigna Moudgalya. "Case report: Brown tumor, a masquerader of malignancy." Indian Journal of Musculoskeletal Radiology 5 (June 29, 2023): 56–60. http://dx.doi.org/10.25259/ijmsr_23_2022.

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There are various causes of multiple lytic lesions in bone in adults, among which metastases and multiple myeloma top the list. Brown tumor is a rare cause of multiple lytic lesions in bone in the present era. This is due to the early diagnosis of hyperparathyroidism by serological investigations and effective treatment. Brown tumor is named after its gross pathological appearance and is focal reactive osteolysis secondary to elevated parathyroid hormone. We herein present a case of a 36-year-old female with multiple osteolytic lesions with high suspicion of metastases, but a methodical radiol

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Dean, Eric W., and Elad Ziv. "African-American Multiple Myeloma Patients Exhibit Less Bone Disease Compared to Other Racial/Ethnic Groups." Blood 116, no. 21 (2010): 4994. http://dx.doi.org/10.1182/blood.v116.21.4994.4994.

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Abstract Abstract 4994 Background: Bone destruction remains one of the major complications in Multiple Myeloma (MM) leading to morbidity and mortality. African-Americans have a higher incidence of MM but exhibit longer survivals compared to Caucasians. We analyzed bone involvement in a cohort of patients with MM to determine if non African American (non AA) vs. African American (AA) race predicts the presence and severity of bone disease at presentation. Methods: Clinical data was gathered on 197 (176 non AA and 21 AA) MM patients at the University of California, San Francisco. Each patient ha

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Agarwal, Anil, Kumar Shashi Kant, Anubrat Kumar, Abbas Shaharyar, Indreshwar Verma, and Tarun Suri. "LYTIC LESIONS OF DISTAL RADIUS IN CHILDREN: A RARE TUBERCULAR PRESENTATION." Hand Surgery 19, no. 03 (2014): 369–74. http://dx.doi.org/10.1142/s0218810414500294.

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Introduction: We report the presentation, management, and outcome in five children with osteoarticular tuberculosis of distal radius. Patients: Patients were recruited in a prospective study. All patients underwent an open biopsy, curettage and diagnosis confirmed by histopathological/microbiological examination. In cavitary lytic lesions, bone grafting was also undertaken. The multidrug anti-tubercular chemotherapy was given for one year. Observations: Five patients were included in the study. The average follow-up post-completion chemotherapy was 34.8 months. Bony lesions presented as a poor

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Yalamanchi, Amulya, Adlyne Reena Asirvatham, Karthik Balachandran, Shriram Mahadevan, Sandhya Sundaram, and S. Rajendiran. "Erdheim Chester Disease – Unusual Presentation with Isolated Skeletal Lytic Lesions." Journal of Orthopaedic Case Reports 12, no. 1 (2022): 63–67. http://dx.doi.org/10.13107/jocr.2022.v12.i01.2620.

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Introduction:Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis (LCH) of unknown origin that was first described in 1930. Since then, almost 600 cases have been reported worldwide. Even though this disease primarily affects the bone, it has a varied clinical spectrum of presentation ranging from asymptomatic bone lesions to multisystem involvement. Owing to its protean manifestations ECD is often misdiagnosed or diagnosed late. Case Report:We present a 48-year-old female with a long long-standing history of recurrent bone lesion of the tibia and multiple trivial trauma f

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Chen, Bangzheng J., Huixiao Hong, Weigong Ge, et al. "Surface Chemistry Proteomics and Biomarker Discovery in Multiple Myeloma." Blood 106, no. 11 (2005): 2493. http://dx.doi.org/10.1182/blood.v106.11.2493.2493.

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Abstract Introduction: To further evaluate the utility of surface-enhanced laser desorption and ionization-time of flight mass spectroscopy (SELDI-TOF MS) proteomics in the diagnosis, prognosis, monitoring response to therapy, and follow up of patient with myeloma, we examined the ability of protein chips with 4 different surface chemistries to detect biomarkers of lytic bone disease. Method: Sera from 47 untreated myeloma patients were collected and stored at −80°C for future analysis. 22 serum samples were from patients with 1–26 lytic bone lesions as identified on X-ray skeletal surveys and

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Gülçin Bozbeyoğlu, Sabriye, and Ayse Nur Toksoz Yildirim. "Can we distinguish conventional osteosarcoma subtypes (osteoblastic and chondroblastic) based on their magnetic resonance signal intensities?" Srpski arhiv za celokupno lekarstvo, no. 00 (2023): 85. http://dx.doi.org/10.2298/sarh220920085g.

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Introduction/Objectives. Osteosarcoma (OS) is the most common primary malignant bone tumor in adolescents and young adults, with a tendency to produce variable amounts of osteoid, cartilage, and fibrous matrices. The objective of this study is to differentiate between osteosarcoma subtypes osteoblastic and chondroblastic according to their magnetic resonance (MR) signal intensities and X-ray findings. Methods. We performed a retrospective analysis for 21 pathologically proven osteosarcoma subtypes: osteoblastic (n = 14) and chondroblastic (n = 7). Conventional images of the bone of origin, per

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A., Aria Jyothi, and Lilarani Vijayaraghavan. "Lytic lesions of bone: a cytological and histopathological correlative study." International Journal of Advances in Medicine 8, no. 3 (2021): 382. http://dx.doi.org/10.18203/2349-3933.ijam20210480.

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Background: Lytic lesions of bone are easier to aspirate and fine needle aspiration cytology aids in an earlier diagnosis. The findings are correlated with radiological findings and subsequent histopathological diagnosis. Sensitivity, specificity, positive and negative predictive value of fine needle aspiration cytology of lytic lesions of bone evaluated.Methods: It was a descriptive study for 2 years. All types of lytic lesions of bone were aspirated with fine needle along with radiological assistance. The cytological diagnosis was correlated with histo pathological diagnosis.Results: A total

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Dragosloveanu, Serban, Stefan Cristea, and Dan Zaharie. "Osteoconductive Bone Substitutes as Treatment of Benign Lytic Lesions." Key Engineering Materials 587 (November 2013): 422–26. http://dx.doi.org/10.4028/www.scientific.net/kem.587.422.

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Benign lytic lesions represent a frequent pathology in our clinic. Regarding therapy, we approach these benign tumors through curettage and filling the defects with bone grafting or bone substitutes like hydroxyapatite crystals and tricalcium phosphate.We want to evaluate the efficiency of both bone grafts and bone substitutes regarding bone consolidation, osseointegration and time until absorption for tricalcium phosphate and hydroxyapatite crystals combination. We analyzed 14 patients treated in our clinic through curettage and defect filling during the last three years: 9 patients’ benefici

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Gunalp, Bengul, Ali Ozan Oner, Semra Ince, Engin Alagoz, Aslı Ayan, and Nuri Arslan. "Evaluation of radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT." Radiology and Oncology 49, no. 2 (2015): 115–20. http://dx.doi.org/10.1515/raon-2015-0012.

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Abstract Background. The aim of the study was to retrospectively evaluate radiographic and metabolic changes in bone metastases in response to systemic therapy with 18FDG-PET/CT and determine their roles on the evaluation of therapy response. Patients and methods. We retrospectively evaluated radiographic and metabolic characteristics of bone metastases in 30 patients who were referred for the evaluation of response to systemic therapy with 18FDG-PET/CT. All patients underwent integrated 18FDG-PET/CT before and after treatment. Results. The baseline radiographic patterns of the target lesions

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Kaiser, Martin, Maren Mieth, Peter Liebisch, et al. "Serum Concentrations of DKK-1 Correlate with the Extent of Bone Disease in Multiple Myeloma." Blood 110, no. 11 (2007): 3518. http://dx.doi.org/10.1182/blood.v110.11.3518.3518.

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Abstract Objectives: Lytic bone disease is a hallmark of multiple myeloma (MM) and is caused by osteoclast activation and osteoblast inhibition. Secretion of Dickkopf (DKK)-1 by myeloma cells was reported to cause inhibition of osteoblast precursors. DKK-1 is an inhibitor of the Wnt/β-catenin signaling, which is a critical signaling pathway for the differentiation of mesenchymal stem cells into osteoblasts. So far there is no study showing a significant difference in serum DKK-1 levels in MM patients with or without lytic bone lesions. Methods: DKK-1 serum levels were quantified in 184 previou

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Gray, Madison Tanner, Michael Nevin Rutherford, Denis Maurice Bonin, Bruce Patterson, and Pedro Guarionex Lopez. "Hairy-Cell Leukemia Presenting As Lytic Bone Lesions." Journal of Clinical Oncology 31, no. 25 (2013): e410-e412. http://dx.doi.org/10.1200/jco.2012.47.5301.

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Alcafache, Margarida, Susana Ramos, Pedro Alves, Delfin Tavares, and Catarina Gouveia. "Uncommon Kingella kingae lytic bone lesions in children." Pediatrics International 58, no. 3 (2016): 244–45. http://dx.doi.org/10.1111/ped.12886.

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Nicholson, A. G., E. Anderson, S. Saha, M. Indrajith, B. Conry, and J. Hughes. "Progressive dyspnoea, pleural effusions and lytic bone lesions." Thorax 63, no. 6 (2008): 492. http://dx.doi.org/10.1136/thx.2007.091074.

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Jung, Sung-Hoon, Jae-Sook Ahn, Deok-Hwan Yang, Yeo-Kyeoung Kim, Hyeoung-Joon Kim, and Je-Jung Lee. "Effect Of Advanced Lytic Bone Lesions On Peripheral Stem Cell Mobilization In Patients With Multiple Myeloma." Blood 122, no. 21 (2013): 3276. http://dx.doi.org/10.1182/blood.v122.21.3276.3276.

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Abstract The purpose of this study was to identify incidence and predictive factors of peripheral blood stem cell (PBSC) mobilization failure in patients with multiple myeloma (MM). Retrospective data of 104 patients who received cyclophosphamide plus G-CSF or G-CSF alone mobilization were analyzed. The rate of mobilization failure using two definitions of failure < 2 and < 4 ´ 106 CD34+ cells/kg following the first collection attempt was 16.3% and 33.7%, respectively. Predictors of mobilization failure were evaluated using logistic regression analysis including age, advanced osteolytic

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Bataille, R., D. Chappard, C. Marcelli, et al. "Mechanisms of bone destruction in multiple myeloma: the importance of an unbalanced process in determining the severity of lytic bone disease." Journal of Clinical Oncology 7, no. 12 (1989): 1909–14. http://dx.doi.org/10.1200/jco.1989.7.12.1909.

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In order to clarify the mechanisms involved in the occurrence of lytic bone lesions (BL) in multiple myeloma (MM), we have compared the presenting myeloma-induced histological bone changes of 14 previously untreated MM patients with lytic BL with those of seven MM patients lacking lytic BL at presentation despite similar myeloma cell mass. A major unbalanced bone remodeling (increased bone resorption with normal to low bone formation) was the characteristic feature of patients presenting lytic BL. Furthermore, this unbalanced process was associated with a significant reduction of bone mass. Un

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Bashir, Elrofai Suliman, Angel Khor Nee Kwan, Chris Yin Wei Chan, and Mun Keong Kwan. "Remarkable Bone Formation following Gefitinib for Extensive Lytic Bone Metastasis: A Report of Two Cases." Journal of Orthopaedic Surgery 24, no. 3 (2016): 421–23. http://dx.doi.org/10.1177/1602400330.

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Gefitinib inhibits the epidermal growth factor receptor tyrosine kinase and improves survival in patients with non-small-cell lung cancer. We report 2 patients with extensive lytic bony metastasis in the spine and pelvis secondary to advanced pulmonary adenocarcinoma who were treated with gefitinib and had remarkable bone formation in the lytic bone lesions in the spine and pelvis. Surgery for stabilisation was avoided.

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Østergaard, Brian, Julie R. Mortensen, Anne L. Nielsen, et al. "18F-FDG-PET/CT and Osteolytic Bone Disease in Multiple Myeloma." Blood 128, no. 22 (2016): 5622. http://dx.doi.org/10.1182/blood.v128.22.5622.5622.

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Abstract Introduction: FDG-PET/CT is a promising methodology for staging, prognostication, and response evaluation in multiple myeloma (MM). The number of focal FDG lesions and the intensity of FDG uptake (standard uptake value, SUV) at diagnosis are informative of disease aggressiveness. Osteolytic bone disease is a hallmark of MM. Hypothetically; increased focal metabolic activity will precede, induce and correlate to osteolytic lesions. We aimed to elucidate the association between focal FDG positive lesions and osteolytic bone disease in MM patients. Methods: Twenty-two newly diagnosed MM

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Dumitru, Adrian, Mariana Costache, Bogdan Şerban, et al. "Posttraumatic intraosseous epidermoid inclusion cyst. A case report and short literature review." Romanian Journal of Orthopaedic Surgery and Traumatology 3, no. 1 (2020): 3–8. http://dx.doi.org/10.2478/rojost-2020-0002.

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AbstractEpidermoid bone inclusion cysts are pathological structures bordered by a layer of stratified squamous epithelium containing keratin debris. They are also called epidermal bone cysts. Intraosseous epidermoid cysts are rare entities; these lesions may occur as a result of trauma (puncture wound or pressure erosion).They appear to be well defined, translucent lytic lesions with sclerotic margins on imaging studies. The most frequent sites affected are: the distal phalanx and the calvaria - intradiploic, but a few cases of larger bone involvement have been reported. The imagistic differen

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KC, Sudeep, Manisha Paneru, Deepak Yadav, and Manisha Shrestha. "Multifocal brown tumour associated with parathyroid adenoma." Journal of Patan Academy of Health Sciences 11, no. 3 (2024): 19–22. https://doi.org/10.3126/jpahs.v11i3.80180.

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Brown tumors are focal lytic bone lesions associated with primary or secondary hyperparathyroidism. In the present era, brown tumors causing multiple lytic bone lesions are rare due to the early detection of hyperparathyroidism through biochemical investigations and effective treatment. We report a case of a 30-year-old woman initially thought to have a bone tumor in her tibia, but further radiological and biochemical investigations revealed primary hyperparathyroidism with multiple brown tumors. This case emphasizes the importance of using imaging techniques to accurately diagnose and treat u

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Chambers, J. N., S. M. Newell, and J. M. Duval. "Surgical Treatment of an Aneurysmal Bone Cyst in a Dog." Veterinary and Comparative Orthopaedics and Traumatology 08, no. 04 (1995): 213–17. http://dx.doi.org/10.1055/s-0038-1632459.

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Aneurysmal bone cysts are benign but locally aggressive lytic lesions of bone. Surgical curettage and cancellous bone grafting resulted in complete clinical and partial radiographic resolution of an aneurysmal bone cyst of the distal tibia.

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Nida Rasheed and Mairah Razi. "Lytic bony lesions on 18F-FDG PET-CT versus 99mTc MDP bone scan." Journal of the Pakistan Medical Association 73, no. 10 (2023): 2121–22. http://dx.doi.org/10.47391/jpma.23-76.

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With rising incidence of breast carcinoma in Asian population, staging workup remains a crucial entity in diseasemanagement and outcome. Bone scintigraphy for detection of osteoblastic metastasis has remained a convenient choice.However, in the presence of underlying lytic bony lesions sensitivity of 99mTc-MDP bone scan is questionable when comparedto 18F-FDG PET-CT scan. We present a case that showed better sensitivity of 18F-FDG PET-CT for picking up early lytic lesionsfor staging breast cancer.Keywords: breast carcinoma, bone scan, 18F-FDG PET-CT.

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Japour, Christopher, Renato Giorgini, Glenroy Aska, Mary Thomas, and Eric Reynolds. "Intraosseous Lipoma." Journal of the American Podiatric Medical Association 100, no. 6 (2010): 487–92. http://dx.doi.org/10.7547/1000487.

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Intraosseous lipoma is a rare bone tumor that may be encountered in clinical practice. It is benign and is described as a well-defined, radiolucent lesion that must be differentiated from other lytic lesions. Most of these lesions may be treated without surgery; however, when surgery is needed, the classic approach involves curettage and packing using autologous bone grafts, allografts, or synthetic bone substitutes. This article reports two cases using a synthetic bone substitute, TheriLok, to fill the void made from surgical curettage of the intraosseous lipoma. Both patients tolerated the T

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Tothong, Wachiralak, Adisak Tantiworawit, Lalita Norasetthada, et al. "Prevalence, Outcomes and Impact of Disease-Related Complications in the Survival of Multiple Myeloma Patients." Hematology Reports 16, no. 1 (2024): 89–97. http://dx.doi.org/10.3390/hematolrep16010009.

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There are limited data regarding the impact of disease-related complications on the survival of multiple myeloma (MM) patients. The primary objective of this study was to determine the prevalence of disease-related complications, including hypercalcemia, renal insufficiency, anemia, and bone lytic lesions in MM patients. The secondary objectives were to determine clinical characteristics, treatment outcomes, and the association of disease-related complications and mortality. A retrospective chart review of MM patients from November 2014 to December 2019 was conducted. A total of 200 MM patient

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Anderson, Suzanne, Sina Havakeshian, Andreas Würzburg, and Magdalena Lunkiewicz. "Practical Input on Bone Tumor Imaging: Pathological Fracture, Risk Features, and When to Contact Orthopaedics." Seminars in Musculoskeletal Radiology 23, no. 01 (2019): 019–25. http://dx.doi.org/10.1055/s-0038-1675804.

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AbstractAwareness of risk factors associated with impending fracture and its radiologic appearance allows early diagnosis, supports prophylactic surgical treatment, and prevents the multiple complications of a pathologic fracture. Because the femur is the most common long bone affected by metastatic bone lesions, we address this clinically relevant site in this review. The key to early detection of risky bone lesions is familiarity with the possible clinical presentation, biomechanical effects of the anatomical site (femoral head and neck, intertrochanteric zone, proximal diaphysis), and the l

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Bataille, Régis, Daniel Chappard, Christian Marcelli, et al. "Osteoblast stimulation in multiple myeloma lacking lytic bone lesions." British Journal of Haematology 76, no. 4 (1990): 484–87. http://dx.doi.org/10.1111/j.1365-2141.1990.tb07904.x.

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Gramont, Aimery, Oscar Benitez, Philippe Brissaud, et al. "Quantification of bone lytic lesions and prognosis in myelomatosis." Scandinavian Journal of Haematology 34, no. 1 (2009): 78–82. http://dx.doi.org/10.1111/j.1600-0609.1985.tb00747.x.

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Singh Yadav, Bhavya Raj, Ali Asgar, Aakash Bansal, Umesh Kumar Meena, and R. P. Meena. "Role Of Allogenic Bone Graft in Benign Lytic Lesions." Journal of Clinical Orthopaedics and Trauma 57 (October 2024): 102708. http://dx.doi.org/10.1016/j.jcot.2024.102708.

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Iravani, Shohreh, Timothy P. Singleton, Charles W. Ross, and Bertram Schnitzer. "Precursor B Lymphoblastic Lymphoma Presenting as Lytic Bone Lesions." American Journal of Clinical Pathology 112, no. 6 (1999): 836–43. http://dx.doi.org/10.1093/ajcp/112.6.836.

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PIAZZA, I., and G. GIUNTA. "LYTIC BONE LESIONS AND POLYARTHRITIS ASSOCIATED WITH ACNE FULMINANS." Rheumatology 30, no. 5 (1991): 387–89. http://dx.doi.org/10.1093/rheumatology/30.5.387.

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Robbiani, Davide F., Kaity Colon, Sarah Ely, Scott Ely, Marta Chesi, and P. Leif Bergsagel. "Osteopontin dysregulation and lytic bone lesions in multiple myeloma." Hematological Oncology 25, no. 1 (2007): 16–20. http://dx.doi.org/10.1002/hon.803.

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