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Journal articles on the topic 'Lyxicon'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Bella, Maroš, Sergej Šesták, Ján Moncoľ, Miroslav Koóš та Monika Poláková. "Synthesis of 1,4-imino-L-lyxitols modified at C-5 and their evaluation as inhibitors of GH38 α-mannosidases". Beilstein Journal of Organic Chemistry 14 (17 серпня 2018): 2156–62. http://dx.doi.org/10.3762/bjoc.14.189.

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A synthetic approach to 1,4-imino-L-lyxitols with various modifications at the C-5 position is reported. These imino-L-lyxitol cores were used for the preparation of a series of N-(4-halobenzyl)polyhydroxypyrrolidines. An impact of the C-5 modification on the inhibition and selectivity against GH38 α-mannosidases from Drosophila melanogaster, the Golgi (GMIIb) and lysosomal (LManII) mannosidases and commercial jack bean α-mannosidase from Canavalia ensiformis was evaluated. The modification at C-5 affected their inhibitory activity against the target GMIIb enzyme. In contrast, no inhibition ef

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2

Saben, Jessica L., Clark R. Sims, Brian D. Piccolo, and Aline Andres. "Maternal adiposity alters the human milk metabolome: associations between nonglucose monosaccharides and infant adiposity." American Journal of Clinical Nutrition 112, no. 5 (2020): 1228–39. http://dx.doi.org/10.1093/ajcn/nqaa216.

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ABSTRACT Background Human milk composition is altered by maternal obesity. The association between milk metabolites and infant outcomes has not been thoroughly investigated. Objectives This study aimed to quantify maternal adiposity-related differences in the human milk metabolome and to identify metabolites associated with infant adiposity during the first 6 mo postpartum using untargeted metabolomics. Method Maternal anthropometrics were assessed ≤14 weeks of gestation. Human milk samples were collected at 0.5 mo (n = 159), 2 mo (n = 131), and 6 mo (n = 94) postpartum from normal weight (NW,

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3

Trajkovic, Milos, Milos Pavlovic, Filip Bihelovic, Zorana Ferjancic, and Radomir N. Saicic. "Total Synthesis of ( + )-Swainsonine, (–)- Swainsonine, ( + )-8-epi-Swainsonine and ( + )- Dideoxy-Imino-Lyxitol by an Organocatalyzed Aldolization/Reductive Amination Sequence." Natural Product Communications 17, no. 4 (2022): 1934578X2210916. http://dx.doi.org/10.1177/1934578x221091672.

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A tactical combination of either ( S)- or ( R)-proline catalyzed aldol reaction followed by intramolecular reductive amination enabled the synthesis of a chiral pyrrolidine derivative with 3 contiguous stereocenters in only 2 synthetic steps, starting from achiral precursors. This product, obtainable in both enantiomeric forms, was further exploited as a common intermediate in total syntheses of the biologically active iminosugars: ( + )-swainsonine, (–)-swainsonine, ( + )-8- epi-swainsonine, and ( + )-dideoxy-imino-lyxitol.

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4

Oba, Makoto, Shoi Kawaji, Hironobu Kushima, Takanori Sano, and Kozaburo Nishiyama. "Convenient Synthesis of 1,4-Dideoxy-1,4-imino-D-ribitol from D-Ribose." Journal of Chemistry 2013 (2013): 1–5. http://dx.doi.org/10.1155/2013/519415.

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This paper describes a convenient synthesis of 1,4-dideoxy-1,4-imino-D-ribitol (DRB) from D-ribose. L-Lyxonolactone, a key intermediate in this synthesis, was prepared by base-promoted hydrolysis of a 5-chlorinated D-ribonolactone derivative with inversion of configuration at the C-4 position. Cyclization of the generated dimesylated L-lyxitol with benzylamine proceeded with another configurational inversion at C-4 to afford the D-ribo-configured pyrrolidine system, which upon deprotection gave DRB.

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5

Holliman, Anna, Priyanka Banerjee, and Paul W. W. Dyce. "167 Plasma Metabolomics at Weaning and 30 Days Prior to Ai in Beef Heifers with Varying Reproductive Potential." Journal of Animal Science 101, Supplement_3 (2023): 60–61. http://dx.doi.org/10.1093/jas/skad281.074.

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Abstract Cattle are an economically important species, and subfertility is one of the reasons for economical loss for producers. Despite the use of phenotypic measures in selection, such as body condition score, reproductive tract score and age, a subset of heifers will fail to conceive by the end of a defined breeding season. Therefore, diagnostic biomarkers are desired that can successfully discriminate fertile and subfertile beef heifers. Metabolites are small molecules present in biofluids and tissues, relating to metabolic processes of cells and organs. The metabolome, the global populati

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6

Pan, Weidong, Christophe Ansiaux, and Stéphane P. Vincent. "Synthesis of acyclic galactitol- and lyxitol-aminophosphonates as inhibitors of UDP-galactopyranose mutase." Tetrahedron Letters 48, no. 25 (2007): 4353–56. http://dx.doi.org/10.1016/j.tetlet.2007.04.113.

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7

Kumar, Nag S., and B. Mario Pinto. "Synthesis of d-lyxitol and d-ribitol analogues of the naturally occurring glycosidase inhibitor salacinol." Carbohydrate Research 340, no. 17 (2005): 2612–19. http://dx.doi.org/10.1016/j.carres.2005.09.004.

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8

Mudiganti, Ram Krishna Rao*and Balasubramaniam M. "TLC, GC MS AND ANTIBACTERIAL STUDY OF METHANOL EXTRACTS OF TRIBULUS TERRESTRIS THORNS AND MORINAGA OLEIFERA FLOWERS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 05 (2018): 3300–3308. https://doi.org/10.5281/zenodo.1240460.

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The two medicinal plants namely, Moringa oleifera and Tribulus terrestris are well known for their medicinal roles ethnobotanically. The present work is to understand the presence of phytochemicals in each of them by TLC method and by GC MS analysis. The antibacterial study was also conducted for both the plants. The TLC profiles show the presence of terpenoids, steroids, flavonoids and alkaloids in both the plants. It was observed that antibacterial role of Tribulus terrestris was evident but Moringa flower extract did not show any antibacterial activity. The GC MS results show the presence o

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9

Hun Park, Ki, Ki Chang Jang, Ill-Yun Jeong, Min Suk Yang, and Sang Uk Choi. "Stereoselective Synthesis of 1,4-Dideoxy-1,4-imino-L-lyxitol and 1,5-Dideoxy-1,5-imino-D-ribitol." HETEROCYCLES 53, no. 4 (2000): 887. http://dx.doi.org/10.3987/com-99-8832.

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10

Kato, Atsushi, Jackie Hollinshead, Yukiko Yamashita та ін. "An α-glucoside of 1,4-dideoxy-1,4-imino-d-lyxitol with an eleven carbon side chain". Phytochemistry Letters 3, № 4 (2010): 230–33. http://dx.doi.org/10.1016/j.phytol.2010.08.006.

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11

Crotti, Paolo, Valeria Di Bussolo, Lucilla Favero, Claudia Gozzi, and Mauro Pineschi. "Difuntionalised oxirane systems. Stereodivergent synthesis of 1,4;2,3-dianhydro-5-O-benzyl-l-lyxitol and -l-ribitol." Tetrahedron: Asymmetry 8, no. 10 (1997): 1611–21. http://dx.doi.org/10.1016/s0957-4166(97)00136-5.

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12

CROTTI, P., V. DI BUSSOLO, L. FAVERO, C. GOZZI, and M. PINESCHI. "ChemInform Abstract: Difunctionalized Oxirane Systems. Stereodivergent Synthesis of 1,4;2,3- Dianhydro-5-O-benzyl-L-lyxitol and -L-ribitol." ChemInform 28, no. 41 (2010): no. http://dx.doi.org/10.1002/chin.199741257.

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13

Jang, Ki Chang, Ill-Yun Jeong, Min Suk Yang, Sang Uk Choi, and Ki Hun Park. "ChemInform Abstract: Stereoselective Synthesis of 1,4-Dideoxy-1,4-imino-L-lyxitol and 1,5-Dideoxy-1,5-imino-D-ribitol." ChemInform 31, no. 31 (2010): no. http://dx.doi.org/10.1002/chin.200031208.

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14

Guo-qiang, Lin, Shi Zhi-cai, and Zeng Chun-min. "A Synthesis of the Polyhydroxylated Pyrrolidines : Synthesis of 1,4-Dideoxy-1,4-imino-D-lyxitol and N-Benzyl-4-epi-(-)-Anisomycin." HETEROCYCLES 41, no. 2 (1995): 277. http://dx.doi.org/10.3987/com-94-6904.

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15

Duréault, Annie, Christine Greck, and Jean-Claude Depezay. "A New Route to Pyrrolidines: One-Step Cyclization of 1,4-Azido Alcohol Synthesis of 1,4-Dideoxy-1,4-Imino-L-Lyxitol." Journal of Carbohydrate Chemistry 9, no. 1 (1990): 121–23. http://dx.doi.org/10.1080/07328309008545803.

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16

Mercer, Thomas B., Sarah F. Jenkinson, Barbara Bartholomew та ін. "Looking glass inhibitors: both enantiomeric N-benzyl derivatives of 1,4-dideoxy-1,4-imino-d-lyxitol [a potent competitive inhibitor of α-d-galactosidase] and of 1,4-dideoxy-1,4-imino-l-lyxitol [a weak competitive inhibitor of α-d-galactosidase] inhibit naringinase, an α-l-rhamnosidase competitively". Tetrahedron: Asymmetry 20, № 20 (2009): 2368–73. http://dx.doi.org/10.1016/j.tetasy.2009.10.004.

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17

Meyers, A. I., C. J. Andres, James E. Resek, Maureen A. McLaughlin, Charlotte C. Woodall, and P. H. Lee. "A Rapid and Efficient Approach to Chiral, Nonracemic Aza Sugars from Nonsugars. A Formal Synthesis of 1,4-Dideoxy-1,4-imino-d-lyxitol." Journal of Organic Chemistry 61, no. 8 (1996): 2586–87. http://dx.doi.org/10.1021/jo960129k.

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18

SHI, Z., C. ZENG, and G. LIN. "ChemInform Abstract: A Synthesis of the Polyhydroxylated Pyrrolidines: Synthesis of 1,4- Dideoxy-1,4-imino-D-lyxitol and N-Benzyl-4-epi-(-)-anisomycin." ChemInform 26, no. 29 (2010): no. http://dx.doi.org/10.1002/chin.199529292.

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19

MEYERS, A. I., C. J. ANDRES, J. E. RESEK, M. A. MCLAUGHLIN, C. C. WOODALL, and P. H. LEE. "ChemInform Abstract: A Rapid and Efficient Approach to Chiral, Nonracemic Aza Sugars from Nonsugars. A Formal Synthesis of 1,4-Dideoxy-1,4-imino-D-lyxitol." ChemInform 27, no. 34 (2010): no. http://dx.doi.org/10.1002/chin.199634237.

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20

Meyers, A. I., Charles J. Andres, James E. Resek, et al. "Asymmetric routes to azasugars from chiral bicyclic lactams. Synthesis of 1,4-dideoxy-1,4-imino-D-lyxitol; L-deoxymannojirimycin; rhammo-1-deoxynojirimycin and 1-deoxy-6-epicastanospermine." Tetrahedron 55, no. 29 (1999): 8931–52. http://dx.doi.org/10.1016/s0040-4020(99)00454-8.

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21

Meyers, A. I., Charles J. Andres, James E. Resek, et al. "ChemInform Abstract: Asymmetric Routes to Azasugars from Chiral Bicyclic Lactams. Synthesis of 1,4-Dideoxy-1,4-imino-D-lyxitol; L-Deoxymannojirimycin; Rhammo-1-deoxynojirimycin and 1-Deoxy-6-epicastanospermine." ChemInform 30, no. 46 (2010): no. http://dx.doi.org/10.1002/chin.199946197.

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22

Fleet, G. W. J., S. J. Nicholas, P. W. Smith, S. V. Evans, L. E. Fellows та R. J. Nash. "Potent competitive inhibition of α-galactosidase and α-glucosidase activity by 1,4-dideoxy-1,4-iminopentitols: syntheses of 1,4-dideoxy-1,4-imino-d-lyxitol and of both enantiomers of 1,4-dideoxy-1,4-iminoarabinitol". Tetrahedron Letters 26, № 26 (1985): 3127–30. http://dx.doi.org/10.1016/s0040-4039(00)98636-2.

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23

THOMPSON, D. K., C. N. HUBERT, and R. H. WIGHTMAN. "ChemInform Abstract: Hydroxylated Pyrrolidines. Synthesis of 1,4-Dideoxy-1,4-imino-L- lyxitol, 1,4,5-Trideoxy-1,4-imino-D- and -L-lyxo-hexitol, 2,3,6- Trideoxy-3,6-imino-D-glycero-L-altro- and -D-glycero-L-galacto- octitols, and of a Chiral Potential Prec." ChemInform 24, no. 36 (2010): no. http://dx.doi.org/10.1002/chin.199336254.

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24

Thompson, Deryk K., Christine N. Hubert, and Richard H. Wightman. "Hydroxylated pyrrolidines. Synthesis of 1,4-dideoxy-1,4-imino-L-lyxitol, 1,4,5-trideoxy-1,4-imino-D- and -L-lyxo-hexitol, 2,3,6-trideoxy-3,6-imino-D-glycero-L-altro- and -D-glycero-L-galacto-octitols, and of a chiral potential precursor of carbapenem systems." Tetrahedron 49, no. 18 (1993): 3827–40. http://dx.doi.org/10.1016/s0040-4020(01)90234-0.

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25

Fleet, George W. J., Josephine M. Peach, Paul W. Smith, Geoffrey N. Austin, Peter D. Baird та David J. Watkin. "3,6-dideoxy-3,6-imino-1,2-o-isopropylidene-α-d-glucofuranose as a divergent intermediate for the synthesis of hydroxylated pyrrolidines; synthesis of 1,4 dideoxy-1,4-imino-l-gulitol, 1,4-dideoxy-i,4-imino-d-lyxitol, 2S,3S,4R-3,4-dihydroxyproline and (1S,2R,8S,8aR)-1,2,8-trihydroxyoctahydroindolizine [8-epi swainsonine]. X-ray crystal structure of (1S,2R,8S,8aR)-1,2,8-trihydroxy-5-oxo octahydroindolizine". Tetrahedron 43, № 13 (1987): 3095–108. http://dx.doi.org/10.1016/s0040-4020(01)86851-4.

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26

Azizjan, Mukhammadjonov. "ANALYSIS OF NOUNS IN THE ARABIC LANGUAGE REGARDING THE COLOR FIELD, THEIR STEMS AND THE MEANINGS OF SYNONYMS ("المعجم الوسيط" BASED ON THE WORK OF" ("PERFECT EXPLANATORY DICTIONARY" )". 24 вересня 2023. https://doi.org/10.5281/zenodo.8373396.

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<em>The article is devoted to the analysis of scientific opinions on the substantiations of the color field in the Arabic language on the basis of comments made in the work </em><em>“</em>المعجم الوسيط<em>” (“Perfect explanatory dictionary”). The author tried to scientifically analyze the views expressed by scientists in the article on what is substantiality, the nature of the phenomenon of substantiality in general linguistics. Consequently, the words related to the color field also refer to the qualities of their roots and their analogues, their variety of meanings, a

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27

Kona, Juraj, Sergej Šesták, Iain B. H. Wilson та Monika Polakova. "1,4-Dideoxy-1,4-imino-D- and L-lyxitol-based inhibitors bind to Golgi α-mannosidase II in different protonation forms". Organic & Biomolecular Chemistry, 2022. http://dx.doi.org/10.1039/d2ob01545e.

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Development of effective inhibitors of Golgi α-mannosidase II (GMII, E.C.3.2.1.114) with minimal off-target effects towards the phylogenetically-related lysosomal α-mannosidase (LMan, E.C.3.2.1.24) is a complex task due to complicated structural and...

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28

DUREAULT, A., C. GRECK, and J. C. DEPEZAY. "ChemInform Abstract: A New Route to Pyrrolidines: One-Step Cyclization of 1,4-Azido Alcohol. Synthesis of 1,4-Dideoxy-1,4-imino-L-lyxitol." ChemInform 21, no. 50 (1990). http://dx.doi.org/10.1002/chin.199050155.

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29

FLEET, G. W. J., S. J. NICHOLAS, P. W. SMITH, S. V. EVANS, L. E. FELLOWS та R. J. NASH. "ChemInform Abstract: POTENT COMPETITIVE INHIBITION OF α-GALACTOSIDASE AND α-GLUCOSIDASE ACTIVITY BY 1,4-DIDEOXY-1,4-IMINOPENTITOLS: SYNTHESES OF 1,4-DIDEOXY-1,4-IMINO-D-LYXITOL AND OF BOTH ENANTIOMERS OF 1,4-DIDEOXY-1,4-IMINOARABINITOL". Chemischer Informationsdienst 16, № 41 (1985). http://dx.doi.org/10.1002/chin.198541207.

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30

AUSTIN, G. N., P. D. BAIRD, G. W. J. FLEET, J. M. PEACH, P. W. SMITH та D. J. WATKIN. "ChemInform Abstract: 3,6-Dideoxy-3,6-imino-1,2-O-isopropylidene-α-D-glucofuranose as a Divergent Intermediate for the Synthesis of Hydroxylated Pyrrolidines: Synthesis of 1,4-Dideoxy-1,4-imino-L-gulitol, 1,4-Dideoxy-1,4-imino-D-lyxitol, 2S,3S,4R-3,4-Dihyd". ChemInform 18, № 45 (1987). http://dx.doi.org/10.1002/chin.198745321.

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