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1

Нгуен, Ч. Т. "Аpplicаtiоn оf geоinfоrmаtiоn technоlоgies tо creаte hypsоmetric mаp оf the Lisinsky reseаrch аnd trаining grоund". Известия СПбЛТА, № 234 (5 квітня 2021): 152–65. http://dx.doi.org/10.21266/2079-4304.2021.234.152-165.

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Разработана методика составления и анализа гипсометрических карт на основе применения геоинформационных технологий. Установлено, что высоты над уровнем моря на изучаемой территории составляют от 34 до 102 м; наблюдается постепенное общее снижение высоты в направлении от северо-запада к юго-востоку, как и течение большинства протекающих здесь рек. Проведен статистический анализ полученных результатов, определено распределение площадей изучаемой территории по высоте над уровнем моря, показано, что участки с высотами 60–75 м над уровнем моря занимают более 52% всей изучаемой площади. Предложенная
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2

Khаkimovа, Kаmolа Rаkhimjonovnа, та Shеrzоdbеk Shаvkаt оgli Yоkubоv. "CREАTION АND MАINTENАNCE OF STАTE CАDАSTERS IN THEREPUBLIC OF UZBEKISTАN". Innovations in Science and Technologies 1, № 1 (2024): 85–93. https://doi.org/10.5281/zenodo.10824108.

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This аrticle contаins informаtion аbout the creаtion аnd mаintenаnce of stаte cаdаstres in the Republic of Uzbekistаn, the concept of stаte cаdаstre аnd its content, the unified system of stаte cаdаstres, the аccounting of cаdаstrаl objects, cаdаstrаl documents, cаdаstrаl volumes аnd cаdаstrаl mаps.
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3

Lehtola, Tiina, Elina Nummenmaa, Lauri Tuure, et al. "Dexamethasone Attenuates the Expression of MMP-13 in Chondrocytes through MKP-1." International Journal of Molecular Sciences 23, no. 7 (2022): 3880. http://dx.doi.org/10.3390/ijms23073880.

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Mitogen-activated protein kinase phosphatase-1 (MKP-1) is upregulated in inflammation and reduces the activity of proinflammatory mitogen-activated protein kinases (MAP kinases) by dephosphorylation. MAP kinases are intracellular signaling pathways that mediate the cellular effects of proinflammatory cytokines. In the present study, we investigated the effects of the glucocorticoid dexamethasone on the expression of catabolic enzymes in chondrocytes and tested the hypothesis that these effects are mediated through MKP-1. Dexamethasone was found to significantly attenuate the expression of matr
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4

Yamamoto, *Yuki, Genichi Sugihara, Masaaki Shimizu, et al. "NEUROBIOLOGICAL OVERLAPS AND DIFFERENCES IN METHAMPHETAMINE-INDUCED PSYCHOSIS AND SCHIZOPHRENIA: A RESTING-STATE FMRI AND MACHINE LEARNING STUDY." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i219. https://doi.org/10.1093/ijnp/pyae059.385.

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Abstract Background Methamphetamine-induced psychosis (MIP) is characterized by transient episodes, but a substantial portion persists long-term (Wearne &Cornish 2018). While symptom similarities exist between MIP and schizophrenia (Sz), their neural correlates remain uncertain. Furthermore, research into the neural basis underlying the presence and duration of MIP psychosis has been limited. Aims & Objectives This study aimed to investigate whether there would be differences in discriminatory ability when classifying methamphetamine (METH) users with or without psychosis and Sz using
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5

Page, Patrick, Joshua DeJong, Alaina Bandstra, and Robert A. Boomsma. "Effect of Serum and Oxygen Concentration on Gene Expression and Secretion of Paracrine Factors by Mesenchymal Stem Cells." International Journal of Cell Biology 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/601063.

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Mesenchymal stem cells (MSC) secrete paracrine factors that may exert a protective effect on the heart after coronary artery occlusion. This study was done to determine the effect of hypoxia and serum levels on the mRNA expression and secretion of paracrine factors. Mouse bone marrow MSC were cultured with 5% or 20% serum and in either normoxic (21% O2) or hypoxic (1% O2) conditions. Expression of mRNA for vascular endothelial growth factor (VEGF), monocyte chemotactic protein-1 (MCP-1), macrophage inflammatory protein-1α(MIP-1α), MIP-1β, and matrix metalloproteinase-2 (MMP-2) was determined b
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6

Mardenli, Omar R. "The Progeny test of Friesian sires for milk traits by using the contemporary comparison method." Revista Colombiana de Ciencia Animal - RECIA 13, no. 1 (2021): e747. http://dx.doi.org/10.24188/recia.v13.n1.2021.747.

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In this study, the contemporary comparison method (CC) of half-sibs relation was used to estimate the breeding values of Holstein-Friesian sires for 305 -day milk yield (305-DMY) and basic components of milk traits, 409 records of cows that are daughters of ten sires in eight Syrian dairy farms where used. Result of the study showed differences in the estimated breeding values(ccEBVs), where the E Sire achieved the highest value of 305-DMY trait (254.47 kg), while the B Sire achieved the highest value of milk protein percentage (MPP), milk fat percentage (MFP)and milk lactose percentage (MLP)
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7

Ye, Dongping, Weiguo Liang, Libing Dai, and Yicun Yao. "Moderate Fluid Shear Stress Could Regulate the Cytoskeleton of Nucleus Pulposus and Surrounding Inflammatory Mediators by Activating the FAK-MEK5-ERK5-cFos-AP1 Signaling Pathway." Disease Markers 2018 (June 12, 2018): 1–9. http://dx.doi.org/10.1155/2018/9405738.

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We first applied moderate fluid shear stress to nucleus pulposus cells. The correlation of AP-1 with type II collagen, proteoglycan, Cytokeratin 8 protein, MAP-1, MAP-2, and MAP-4 and the correlation of AP-1 with IL-1β, TNF-α, IL-6, IL-8, MIP-1, MCP-1, and NO were detected. Our results document that moderate fluid shear stress could activate the FAK-MEK5-ERK5-cFos-AP1 signaling pathway. AP1 could downregulate the construct factors of cytoskeleton such as type II collagen, proteoglycan, Cytokeratin 8 protein, MAP-1, MAP-2, and MAP-4 in nucleus pulposus cell after the fluid shear stress was load
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8

Ogata, Ryouji, Nobuhiko Hiramatsu, Kunihiro Hayakawa, et al. "Impairment of MCP-1 Expression in Mesothelial Cells Exposed to Peritoneal Dialysis Fluid by Osmotic Stress and Acidic Stress." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 31, no. 1 (2011): 80–89. http://dx.doi.org/10.3747/pdi.2009.00159.

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BackgroundBacterial peritonitis is one of the most frequent complications in patients on peritoneal dialysis. In the present study, we investigated effects of peritoneal dialysis fluid (PDF) on mesothelial cell recruitment of macrophages, focusing especially on unphysiological properties of PDF.MethodsHuman and murine mesothelial cells were exposed to PDF or individual properties of PDF (low pH, high glucose concentration, hyperosmolality, high lactate concentration) in vitro and in vivo, treated with inflammatory stimuli, and subjected to analyses of monocyte chemo-attractant protein-1 (MCP-1
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9

Villalba, Juan J., Mariana Pedernera, and Alessandro Mereu. "161 Preference for inorganic sources of calcium and phosphorus in sheep." Journal of Animal Science 97, Supplement_3 (2019): 170–71. http://dx.doi.org/10.1093/jas/skz258.351.

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Abstract We determined whether lambs discriminate among mineral supplements containing P and Ca and if they modify their choices as a function of need. During 3 consecutive days, 40 lambs under a basal diet of alfalfa pellets and barley were offered 4-way choices among= (1) Bolifor® Monosodium phosphate (MSP-24% P), (2) Bolifor® Magnesium phosphate (MGP-15% P, 25% Mg), (3) Bolifor® Monocalcium phosphate (MCP-22.7% P, 16.5% Ca) and (4) Dicalcium phosphate (DCP-18.5%P, 23% Ca), and 2-way choices between DCP and each of the remaining minerals (Baseline). Subsequently, lambs were randomly assigned
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Oliveira, Carlos Rocha, Leonardo Mendes Bella, Rodolfo de Paula Vieira, and Marília Cristina Duarte. "Brazilian essential oil of Cymbopogon martinii: positive effects on inflammation-induced human fibroblasts and skin aging." Revista Fitos 18 (June 6, 2024): e1130. http://dx.doi.org/10.32712/2446-4775.2024.1130.

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The aim of the study was to evaluate the effects of essential oil from Cymbopogon martinii (CMEO) on lipopolysaccharide (LPS)-stimulated human fibroblast cells. The fibroblasts were cultured using Iscove's medium and stimulated by LPS (1μg/mL). The cytotoxicity of CMEO was evaluated by MTT and collagen concentration by Sirius red. Collagenase activity, hyaluronic acid, and the concentrations of IL-1β; IL-6; MCP-1, and MIP-1-α were evaluated by ELISA. The effect of CMEO on the mRNA levels and the secretion of MMP-1; MMP-2; and MMP-9 enzymes in fibroblasts were evaluated by RT-qPCR and ELISA,
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11

Diaz, Diego A. Lopez, Su A. Lee, and Hans H. Stein. "149 Effects of Microbial Phytase on Standardized Total Tract Digestibility of Phosphorus in Feed Phosphates Fed to Growing Pigs." Journal of Animal Science 101, Supplement_2 (2023): 114–15. http://dx.doi.org/10.1093/jas/skad341.127.

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Abstract The objective of this experiment was to determine the effect of increased microbial phytase on total tract digestibility of P in feed phosphates when fed to growing pigs. A source of monocalcium phosphate (MCP), monosodium phosphate (MSP), and magnesium phosphate (MgP) were procured. Three basal diets were formulated to contain 0, 500, and 4,000 units of microbial phytase (FTU) and no addition of feed phosphates. Nine phosphate-containing diets were formulated by adding each of the 3 feed phosphates and 3 levels of phytase. A P-free diet was formulated to determine the basal endogenou
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12

Scotece, Morena, Mari Hämäläinen, Tiina Leppänen, Katriina Vuolteenaho, and Eeva Moilanen. "MKP-1 Deficiency Exacerbates Skin Fibrosis in a Mouse Model of Scleroderma." International Journal of Molecular Sciences 24, no. 5 (2023): 4668. http://dx.doi.org/10.3390/ijms24054668.

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Scleroderma is a chronic fibrotic disease, where proinflammatory and profibrotic events precede collagen accumulation. MKP-1 [mitogen-activated protein kinase (MAPK) phosphatase-1] downregulates inflammatory MAPK pathways suppressing inflammation. MKP-1 also supports Th1 polarization, which could shift Th1/Th2 balance away from profibrotic Th2 profile prevalent in scleroderma. In the present study, we investigated the potential protective role of MKP-1 in scleroderma. We utilized bleomycin-induced dermal fibrosis model as a well-characterized experimental model of scleroderma. Dermal fibrosis
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13

Uguccioni, Mariagrazia, Massimo D'Apuzzo, Marcel Loetscher, Beatrice Dewald та Marco Baggiolini. "Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1α and MIP-1β on human monocytes". European Journal of Immunology 25, № 1 (1995): 64–68. http://dx.doi.org/10.1002/eji.1830250113.

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14

Huang, *Ming-Chyi, Tung-Hsia Liu, and Yu-Li Liu. "MORE PRONOUNCED NEUROAXONAL INTEGRITY DISTURBANCES IN METHAMPHETAMINE-ASSOCIATED PERSISTENT PSYCHOSIS COMPARED TO SCHIZOPHRENIA." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i96—i97. https://doi.org/10.1093/ijnp/pyae059.166.

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Abstract Background Methamphetamine (METH) can cause multiple physical and psychological harms. Psychosis is one of the most serious health consequences from using METH, with this requiring aggressive treatment and being associated neurocognitive impairment and structural brain abnormalities. While the majority of METH-associated psychosis are brief (METH-associated brief psychosis, MBP); the psychosis can become persistent for >1 month in a subset of people (METH-associated persistent psychosis, MPP), with a symptom profile substantially similar to schizophrenia. Blood levels of neurof
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15

Konenkov, Konenkov V. I., Koroleva E. G. Koroleva, Orlov N. B. Orlov та ін. "Changes in the serum concentrations of CCL chemokines (MCP-1, MIP-1α, MIP-1β, RANTES, and EOTAXIN) in women with uterine myoma". Akusherstvo i ginekologiia 8_2019 (1 вересня 2019): 107–11. http://dx.doi.org/10.18565/aig.2019.8.107-111.

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16

Zhang, Jizhou, Qingqing Wu, Courtney Johnson, et al. "In Situ Fate Mapping of Native and Stress Myelopoiesis Reveals a Unique Niche for Mono- and Dendritic Cell -Poiesis." Blood 136, Supplement 1 (2020): 38–39. http://dx.doi.org/10.1182/blood-2020-143123.

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In contrast to virtually all other tissues in the body the anatomy of differentiation in the bone marrow remains unknown. This is due to the lack of strategies to examine blood cell production in situ, which are required to better understand differentiation, lineage commitment decisions, and to define how spatial organizing cues inform tissue function. We developed approaches to image and fate map -using confetti mice- myelopoiesis in situ and generated 3D atlases of granulocyte and monocyte/dendritic cell differentiation during homeostasis and after emergency myelopoiesis induced by infection
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Whitney, Darryl, David Klein, Tiffany Rodriguez, Lena Kenny, Eric Strauss, and Matthew Kingery. "Synovial Fluid Biomarkers in the Osteoarthritic Knee: Differences in Concentration with Progression of Radiographic Severity." Orthopaedic Journal of Sports Medicine 8, no. 7_suppl6 (2020): 2325967120S0044. http://dx.doi.org/10.1177/2325967120s00446.

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Objectives: The purpose of the current study was to analyze the synovial fluid concentrations of known inflammatory biomarkers in the setting of symptomatic osteoarthritis (OA) of the knee and assess for any differences in biomarker concentrations based on the extent of radiographic disease. Methods: Patients presenting with knee complaints were invited to provide synovial fluid samples from the symptomatic knee during their initial office visit. For this study, a subset of patients with OA was analyzed. The concentration of 16 synovial fluid biomarkers was measured, including TIMP-1, TIMP-2,
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18

Ewins, J. P., M. D. Waller, M. White, and P. F. Lister. "MIP-map level selection for texture mapping." IEEE Transactions on Visualization and Computer Graphics 4, no. 4 (1998): 317–29. http://dx.doi.org/10.1109/2945.765326.

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19

McQuibban, G. Angus, Jiang-Hong Gong, Julie P. Wong, John L. Wallace, Ian Clark-Lewis, and Christopher M. Overall. "Matrix metalloproteinase processing of monocyte chemoattractant proteins generates CC chemokine receptor antagonists with anti-inflammatory properties in vivo." Blood 100, no. 4 (2002): 1160–67. http://dx.doi.org/10.1182/blood.v100.4.1160.h81602001160_1160_1167.

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Monocyte chemoattractant protein (MCP)–3 is inactivated upon cleavage by the matrix metalloproteinase (MMP) gelatinase A (MMP-2). We investigated the susceptibility to proteolytic processing of the 4 human MCPs by 8 recombinant MMPs to determine whether MCP-3 is an isolated example or represents a general susceptibility of chemokines to proteolytic inactivation by these important inflammatory proteases. In addition to MMP-2, MCP-3 is efficiently cleaved by membrane type 1 (MT1)–MMP, the cellular activator of MMP-2, and by collagenase-1 and collagenase-3 (MMP-1, MMP-13) and stromelysin-1 (MMP-3
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Tran Duc, Thanh, Nhon Dang Hoai, Thao Nguyen Van, et al. "The process of establishing marine spatial planning maps in Vietnam." Vietnam Journal of Marine Science and Technology 23, no. 1 (2023): 1–18. http://dx.doi.org/10.15625/1859-3097/18263.

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Creating a marine spatial planning map (MSP) guides the determination of the map's extent and scale, the map, the content of the map, the methods and techniques of mapping, and the sequence of steps performed. The process consists of 5 steps: 1) Define nature, requirements, scope, and methods, 2) Analyze and evaluate data and information, 3) Make and draw thematic maps and diagrams, 4) MSP mapping, and 5) Make a description of the MSP map. MSP maps' location, scope, and scale are established according to a 3-level system: national, regional, and local. The three-dimensional approach MSP map is
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Trappanese, Danielle M., Sarah Sivilich, Hillevi K. Ets, Farah Kako, Michael V. Autieri, and Robert S. Moreland. "Regulation of mitogen-activated protein kinase by protein kinase C and mitogen-activated protein kinase phosphatase-1 in vascular smooth muscle." American Journal of Physiology-Cell Physiology 310, no. 11 (2016): C921—C930. http://dx.doi.org/10.1152/ajpcell.00311.2015.

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Vascular smooth muscle contraction is primarily regulated by phosphorylation of myosin light chain. There are also modulatory pathways that control the final level of force development. We tested the hypothesis that protein kinase C (PKC) and mitogen-activated protein (MAP) kinase modulate vascular smooth muscle activity via effects on MAP kinase phosphatase-1 (MKP-1). Swine carotid arteries were mounted for isometric force recording and subjected to histamine stimulation in the presence and absence of inhibitors of PKC [bisindolylmaleimide-1 (Bis)], MAP kinase kinase (MEK) (U0126), and MKP-1
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Öztürk, Cemalettin, and Arslan M. Örnek. "A MIP based heuristic for capacitated MRP systems." Computers & Industrial Engineering 63, no. 4 (2012): 926–42. http://dx.doi.org/10.1016/j.cie.2012.06.005.

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23

Smirnov, Ivan E., L. M. Roshal, V. A. Mitish, A. G. Kucherenko, O. V. Karaseva, and I. V. Ponina. "MATRIX METALLOPROTEINASES IN CHILDREN WITH A COMBINED BONE INJURY." Russian Pediatric Journal 22, no. 3 (2019): 170–75. http://dx.doi.org/10.18821/1560-9561-2019-22-3-170-175.

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There were comprehensively examined 55 children, including 35 children with combined bone injury (average age of 12.6 ± 2.3 years), reference group consisted of 20 apparently healthy children (average age of 11.8 ± 2.7 years) without pathology of the motor system. on the 1-3rd and 30th day after the combined bone injury, changes in the content of matrix metalloproteinases (MMP) and cytokines - transforming growth factor-beta (TGF-β), monocytic chemotactic factor (MCP-1) and macrophage inflammatory protein (MIP-1β) were followed in the dynamics by serum immunoassay determination. It was establi
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Dahinden, C. A., T. Geiser, T. Brunner, et al. "Monocyte chemotactic protein 3 is a most effective basophil- and eosinophil-activating chemokine." Journal of Experimental Medicine 179, no. 2 (1994): 751–56. http://dx.doi.org/10.1084/jem.179.2.751.

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CC chemokines constitute a novel class of cytokines that attract and activate monocytes and lymphocytes, as well as basophil and eosinophil leukocytes, with distinct target cell profiles, and are believed to be involved in the regulation of different types of inflammation. The action of the recently identified monocyte chemotactic protein 3 (MCP-3) on human basophil and eosinophil function was studied and compared with that of other CC chemokines. In basophils, MCP-3, MCP-1, RANTES, and macrophage inflammatory protein (MIP)-1 alpha all induced cytosolic-free calcium concentration ([Ca2+]i) cha
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Ghosh, Asish K., Mainak Majumder, Robert Steele, Robert A. White, and Ratna B. Ray. "A Novel 16-Kilodalton Cellular Protein Physically Interacts with and Antagonizes the Functional Activity of c-myc Promoter-Binding Protein 1." Molecular and Cellular Biology 21, no. 2 (2001): 655–62. http://dx.doi.org/10.1128/mcb.21.2.655-662.2001.

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ABSTRACT We initially identified c-myc promoter-binding protein 1 (MBP-1) from a human cervical carcinoma cell expression library which negatively regulates c-myc promoter activity. A recent study demonstrated that MBP-1 acts as a general transcriptional repressor (A. K. Ghosh, R. Steele, and R. B. Ray, Mol. Cell. Biol. 19:2880–2886, 1999). In order to identify the cellular protein(s) interacting with MBP-1 for transcriptional regulation, a HeLa cell cDNA expression library was screened using a yeast two-hybrid system. An MBP-1-interacting cDNA encoding a polypeptide of 140 amino acid residues
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AYDINLIOĞLU, Canan, Ahmet Erhan ÖZDEMİR, and Mustafa ÜNLÜ. "1-Methylcyclopropene (1-MCP) uygulaması ve modifiye atmosferde paketlemenin ‘Fuerte’ avokado çeşidinin muhafazasına etkileri." Mustafa Kemal Üniversitesi Tarım Bilimleri Dergisi 28, no. 1 (2023): 136–52. http://dx.doi.org/10.37908/mkutbd.1182393.

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Bu çalışma ile ‘Fuerte’ avokadolarında 1-Metilsiklopropen (1-MCP) uygulaması, modifiye atmosferde paketleme (MAP) ve MAP+1-MCP uygulamalarının depolama sırasında kaliteye etkileri araştırılmıştır. Kontrol ve uygulama yapılan meyveler 3 ay süreyle 6 °C sıcaklık ve %85-90 oransal nemde depolanmış ve ayda bir depodan çıkarılan örneklerin torba içindeki CO2 konsantrasyonları, ağırlık kayıpları, görünüş, meyve eti sertliği, kabuk ve et rengi, suda çözünebilir toplam kuru madde ve titre edilebilir asit miktarları, meyve suyu pH değeri, yağ ve kuru madde miktarları, mantarsal ve fizyolojik bozulmalar
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Said Abdelqadar Said, Said Abdelqadar Said, and Omar A. Shareef and Abdulkhalik S. Alkazzaz Omar A Shareef and Abdulkhalik S Alkazzaz. "A Density Functional Theory Study of the Isomerization of Substituted 2and#39;-hydroxychalcones to the Corresponding Flavanones." Journal of the chemical society of pakistan 43, no. 1 (2021): 25. http://dx.doi.org/10.52568/000549.

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The transformation of 2and#39;-hydroxychalcones to their corresponding flavanones was studied theoretically by the use of the density functional theory (DFT) with B3-LYP/ 6-311G basis set to get important information about the role of both of electronic and structural properties in this process. The obtained energies were found to be in agreement with our previous results that obtained from HPLC studies. The estimated hardness, polarizability, and electrophilicity profiles were found to obey the maximum hardness principle (MHP), minimum polarizability principle (MPP), and the minimum electroph
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Said Abdelqadar Said, Said Abdelqadar Said, and Omar A. Shareef and Abdulkhalik S. Alkazzaz Omar A Shareef and Abdulkhalik S Alkazzaz. "A Density Functional Theory Study of the Isomerization of Substituted 2and#39;-hydroxychalcones to the Corresponding Flavanones." Journal of the chemical society of pakistan 43, no. 1 (2021): 25. http://dx.doi.org/10.52568/000549/jcsp/43.01.2021.

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The transformation of 2and#39;-hydroxychalcones to their corresponding flavanones was studied theoretically by the use of the density functional theory (DFT) with B3-LYP/ 6-311G basis set to get important information about the role of both of electronic and structural properties in this process. The obtained energies were found to be in agreement with our previous results that obtained from HPLC studies. The estimated hardness, polarizability, and electrophilicity profiles were found to obey the maximum hardness principle (MHP), minimum polarizability principle (MPP), and the minimum electroph
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Said Abdelqadar Said, Said Abdelqadar Said, and Omar A. Shareef and Abdulkhalik S. Alkazzaz Omar A Shareef and Abdulkhalik S Alkazzaz. "A Density Functional Theory Study of the Isomerization of Substituted 2'-hydroxychalcones to the Corresponding Flavanones." Journal of the chemical society of pakistan 43, no. 1 (2021): 25. http://dx.doi.org/10.52568/000008.

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The transformation of 2'-hydroxychalcones to their corresponding flavanones was studied theoretically by the use of the density functional theory (DFT) with B3-LYP/ 6-311G basis set to get important information about the role of both of electronic and structural properties in this process. The obtained energies were found to be in agreement with our previous results that obtained from HPLC studies. The estimated hardness, polarizability, and electrophilicity profiles were found to obey the maximum hardness principle (MHP), minimum polarizability principle (MPP), and the minimum electrophilicit
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30

Said Abdelqadar Said, Said Abdelqadar Said, and Omar A. Shareef and Abdulkhalik S. Alkazzaz Omar A Shareef and Abdulkhalik S Alkazzaz. "A Density Functional Theory Study of the Isomerization of Substituted 2and#39;-hydroxychalcones to the Corresponding Flavanones." Journal of the chemical society of pakistan 43, no. 1 (2021): 25. http://dx.doi.org/10.52568/000369.

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The transformation of 2and#39;-hydroxychalcones to their corresponding flavanones was studied theoretically by the use of the density functional theory (DFT) with B3-LYP/ 6-311G basis set to get important information about the role of both of electronic and structural properties in this process. The obtained energies were found to be in agreement with our previous results that obtained from HPLC studies. The estimated hardness, polarizability, and electrophilicity profiles were found to obey the maximum hardness principle (MHP), minimum polarizability principle (MPP), and the minimum electroph
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31

Gururajan, N., and M. Sambassivame. "Chaos-Logistic Map-Tent Map -Corresponding Cellular Automata." Mapana - Journal of Sciences 9, no. 2 (2010): 28–34. http://dx.doi.org/10.12723/mjs.17.4.

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We study the characteristic features of Tent Mop and Logistic Map towards Chaos. Cellular Automata is obtained for Tent Mop and Logistic Map. The behavior of Tent Mop and Logistic Mop is reflected in the Cellular Automata generated.
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Philipova, R., and M. Whitaker. "MAP kinase activity increases during mitosis in early sea urchin embryos." Journal of Cell Science 111, no. 17 (1998): 2497–505. http://dx.doi.org/10.1242/jcs.111.17.2497.

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A MBP kinase activity increases at mitosis during the first two embryonic cell cycles of the sea urchin embryo. The activity profile of the MBP kinase is the same both in whole cell extracts and after immunoprecipitation with an anti-MAP kinase antibody (2199). An in-gel assay of MBP activity also shows the same activity profile. The activity is associated with the 44 kDa protein that cross-reacts with anti-MAP kinase antibodies. The 44 kDa protein shows cross-reactivity to anti-phosphotyrosine and MAP kinase-directed anti-phosphotyrosine/phosphothreonine antibodies at the times that MBP kinas
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33

Elbedri Abdalla, Omer Abdalla, and Omer A. Musa. "Variability of lung function and respiratory muscles power in healthy and asthmatic subjects." Journal of Lung, Pulmonary & Respiratory Research 6, no. 3 (2019): 64–67. http://dx.doi.org/10.15406/jlprr.2019.06.00209.

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Airway function is one of the many biologic functions that exhibit circadian variability over 24-h periods. Studies of circadian variability of lung function in normal subjects as well as asthmatics are particularly scarce, and those of MEP and MIP are unknown. The aim of this study to determine circadian variation in lung function (FVC, FEV1 and PEFR) and respiratory muscle pressures(MEP and MIP) for measurement of respiratory muscle power at 6:00am (early morning),12:00midday, 6:00pm( evening) and 12:00 midnight in healthy subjects and in patients with mild asthma at 6:00am and 6:00pm , to e
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34

Frydas, S., T. Rallis, I. Theodorides, et al. "Trichinella SpiralisInfection is Mediated by MCP-1 and MIP-2, WhileEchinococcus Granulosusis Strongly Mediated by MCP-1, but Not MIP-2." International Journal of Immunopathology and Pharmacology 13, no. 1 (2000): 21–26. http://dx.doi.org/10.1177/039463200001300103.

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35

Blanpain, Cédric, Isabelle Migeotte, Benhur Lee, et al. "CCR5 Binds Multiple CC-Chemokines: MCP-3 Acts as a Natural Antagonist." Blood 94, no. 6 (1999): 1899–905. http://dx.doi.org/10.1182/blood.v94.6.1899.

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Abstract CCR5 was first characterized as a receptor for MIP-1, MIP-1β, and RANTES, and was rapidly shown to be the main coreceptor for M-tropic human immunodeficiency virus (HIV)-1 strains and simian immunodeficiency virus (SIV). Chemokines constitute a rapidly growing family of proteins and receptor-chemokine interactions are known to be promiscuous and redundant. We have therefore tested whether other CC-chemokines could bind to and activate CCR5. All CC-chemokines currently available were tested for their ability to compete with [125I]-MIP-1β binding on a stable cell line expressing recomb
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36

Blanpain, Cédric, Isabelle Migeotte, Benhur Lee, et al. "CCR5 Binds Multiple CC-Chemokines: MCP-3 Acts as a Natural Antagonist." Blood 94, no. 6 (1999): 1899–905. http://dx.doi.org/10.1182/blood.v94.6.1899.418k31_1899_1905.

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CCR5 was first characterized as a receptor for MIP-1, MIP-1β, and RANTES, and was rapidly shown to be the main coreceptor for M-tropic human immunodeficiency virus (HIV)-1 strains and simian immunodeficiency virus (SIV). Chemokines constitute a rapidly growing family of proteins and receptor-chemokine interactions are known to be promiscuous and redundant. We have therefore tested whether other CC-chemokines could bind to and activate CCR5. All CC-chemokines currently available were tested for their ability to compete with [125I]-MIP-1β binding on a stable cell line expressing recombinant CCR
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37

Cheon, Ji Hong, Na Na Lim, Geun Su Lee, et al. "Differences of Spinal Curvature, Thoracic Mobility, and Respiratory Strength Between Chronic Neck Pain Patients and People Without Cervical Pain." Annals of Rehabilitation Medicine 44, no. 1 (2020): 58–68. http://dx.doi.org/10.5535/arm.2020.44.1.58.

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Objective To investigate the differences of spinal curvature, thoracic sagittal mobility, and respiratory strength between patients with chronic neck pain (CNP) and people without cervical pain, and to determine the correlation between respiratory strength and thoracic mobility in CNP patients.Methods A total of 78 participants were finally included in this study, of whom 30 had no cervical pain and 48 had CNP. The Neck Disability Index (NDI), cervical lordotic curvature, thoracic kyphotic curvature, thoracic sagittal range of motion (ROM), maximal inspiratory pressure (MIP), and maximal expir
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38

Diab, Asim, Hana Abdalla, Hu Lun Li та ін. "Neutralization of Macrophage Inflammatory Protein 2 (MIP-2) and MIP-1α Attenuates Neutrophil Recruitment in the Central Nervous System during Experimental Bacterial Meningitis". Infection and Immunity 67, № 5 (1999): 2590–601. http://dx.doi.org/10.1128/iai.67.5.2590-2601.1999.

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ABSTRACT Chemokines are low-molecular-weight chemotactic cytokines that have been shown to play a central role in the perivascular transmigration and accumulation of specific subsets of leukocytes at sites of tissue damage. Using in situ hybridization (ISH), we investigated the mRNA induction of macrophage inflammatory protein 2 (MIP-2), MIP-1α, monocyte chemoattractant protein 1 (MCP-1), and RANTES. Challenge of infant rats’ brains with Haemophilus influenzae type b intraperitoneally resulted in the time-dependent expression of MIP-2, MIP-1α, MCP-1, and RANTES, which was maximal 24 to 48 h po
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39

Kanwal, Rabia, Hadeed Ashraf, Muhammad Sultan, et al. "Effect of 1-Methyl Cyclopropane and Modified Atmosphere Packaging on the Storage of Okra (Abelmoschus esculentus L.): Theory and Experiments." Sustainability 12, no. 18 (2020): 7547. http://dx.doi.org/10.3390/su12187547.

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Okra possesses a short shelf-life which limits its marketability, thereby, the present study investigates the individual and combined effect of 1-methylcyclopropene (1-MCP) and modified atmosphere packaging (MAP) on the postharvest storage life of okra. The treated/ untreated okra samples were stored at ambient (i.e., 27 °C) and low (i.e., 7 °C) temperatures for eight and 20 days, respectively. Results revealed that the 1-MCP and/or MAP treatment successfully inhibited fruit softening, reduction in mucilage viscosity, and color degradation (hue angle, ∆E, and BI) in the product resulting in a
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40

Christiana, I., R. Aparnaa, R. Rohit, D. Nageswara Rao, and P. Kaliraj. "Effect of muramyl dipeptide and alum adjuvants on immunization with Filarial multi antigen peptide vaccine in mice model." Helminthologia 53, no. 3 (2016): 224–32. http://dx.doi.org/10.1515/helmin-2016-0022.

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SummaryFilarial thioredoxin and transglutaminase are enzymes that are secreted throughout the lifecycle of the parasites which are mandatory for the survival of the parasite. They are reported to be promising vaccine candidates, yet the limitation factors of these proteins to be developed as vaccines is their homology they share with the host proteins. Hence immunodominant epitopes from these proteins were constructed as peptides and immunised in mice model with Muramyl dipeptide (MDP) as adjuvant. Immunodominant epitopic portions from Filarial thioredoxin and transglutaminase which are non-ho
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41

Calvert, Thomas J., Louis G. Chicoine, Yusen Liu, and Leif D. Nelin. "Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin." American Journal of Physiology-Heart and Circulatory Physiology 294, no. 4 (2008): H1621—H1629. http://dx.doi.org/10.1152/ajpheart.01008.2007.

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Mitogen-activated protein kinase phosphatase-1 (MKP-1) is essential in limiting the proinflammatory response to lipopolysaccharide (LPS). We hypothesized that Mkp-1−/− mice would respond to low-dose LPS with a fall in blood pressure due to augmented expression of inducible nitric oxide (NO) synthase (iNOS). To test this hypothesis, Mkp-1−/− mice and their wild-type littermates were treated with 10 μg/kg iv LPS, and mean arterial blood pressure (MAP) and exhaled NO production (exNO) were measured. Tissues were harvested for an assessment of iNOS protein levels. Wild-type mice had no change in M
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42

Vissers, Marloes, Yvonne Hartman, Laszlo Groh, Dirk J. de Jong, Marien I. de Jonge, and Gerben Ferwerda. "Recognition of Streptococcus pneumoniae and Muramyl Dipeptide by NOD2 Results in Potent Induction of MMP-9, Which Can Be Controlled by Lipopolysaccharide Stimulation." Infection and Immunity 82, no. 12 (2014): 4952–58. http://dx.doi.org/10.1128/iai.02150-14.

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ABSTRACTMatrix metallopeptidase 9 (MMP-9) is a protease involved in the degradation of extracellular matrix collagen. Evidence suggests that MMP-9 is involved in pathogenesis duringStreptococcus pneumoniaeinfection. However, not much is known about the induction of MMP-9 and the regulatory processes involved. We show here that the Gram-positive bacteria used in this study induced large amounts of MMP-9, in contrast to the Gram-negative bacteria that were used. An important pathogen-associated molecular pattern (PAMP) for Gram-positive bacteria is muramyl dipeptide (MDP). MDP is a very potent i
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43

Zhang, Jizhou, Qingqing Wu, Courtney Johnson, et al. "Spatial Mapping of Myelopoiesis Reveals the Bone Marrow Niche for Monocyte Dendritic Cell Progenitors." Blood 134, Supplement_1 (2019): 528. http://dx.doi.org/10.1182/blood-2019-128809.

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Monocytes, macrophages and dendritic cells are indispensable for innate immunity. Myelopoiesis takes place in the bone marrow (BM) through differentiation of a common myeloid progenitor into monocyte dendritic cell progenitors (MDP) or granulocyte monocyte progenitors (GMP). MDP differentiate into myeloid progenitors (MoP) or common dendritic progenitors (cDP) that give rise to monocytes or dendritic cells (DC) repectively. GMP can also generate neutrophil-like monocytes via an intermediate monocyte progenitor [MP; Immunity. 2017 47(5):890] and neutrophils via a granulocyte progenitor (GP). CS
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44

HUTTER, Dorothy, Peili CHEN, Janice BARNES, and Yusen LIU. "Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation." Biochemical Journal 352, no. 1 (2000): 155–63. http://dx.doi.org/10.1042/bj3520155.

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Mitogen-activated protein (MAP) kinase phosphatase-1 (MKP-1) is the archetypal member of the dual-specificity protein phosphatase family, the expression of which can be rapidly induced by a variety of growth factors and cellular stress. Since MKP-1 protein localizes in the nucleus, it has been suggested to play an important role in the feedback control of MAP kinase-regulated gene transcription. Recently it has been demonstrated that the interaction of several cytosolic MAP kinase phosphatases with MAP kinases can trigger the catalytic activation of the phosphatases. It is unclear whether such
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45

Matsumura, Shinya, Osamu Dohi, Nobuhisa Yamada, et al. "Improved Visibility of Early Gastric Cancer after Successful Helicobacter pylori Eradication with Image-Enhanced Endoscopy: A Multi-Institutional Study Using Video Clips." Journal of Clinical Medicine 10, no. 16 (2021): 3649. http://dx.doi.org/10.3390/jcm10163649.

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The visibility and diagnostic accuracy of early gastric cancer (EGC) after Helicobacter pylori (HP) eradication have been reported to improve using image-enhanced endoscopy (IEE) compared with white light imaging (WLI). The present study clarified the appropriate IEE for the detection and diagnosis of EGC in clinical settings. This prospective and cross-sectional study evaluated the visibility of EGC and endoscopic findings of gastric mucosa after successful HP eradication (n = 31) using videos with WLI and IEE. Three endoscopists evaluated high-definition videos in a randomized order. The mea
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46

Sindhuja, Anala, and Ananda Bangera. "Modified Ramped Position: Is It the New Hope to Overcome Unanticipated Difficult Airway? A Comparative Study." Journal of Datta Meghe Institute of Medical Sciences University 19, no. 4 (2024): 677–85. https://doi.org/10.4103/jdmimsu.jdmimsu_246_24.

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Background: The prevalence of unanticipated difficult intubation is low but consistent making it a critical problem for anesthesiologists in an operating room. To overcome such life-threatening situations, we have attempted to estimate the benefits of the modified ramped position (MRP) over the classical morning sniffing position (MSP) in the general population. To achieve MRP, we have used the Hasanin pillow which was earlier tried for obese patients. Aim and Objectives: The aim of the study was to assess the usefulness of MRP for laryngoscopy and intubation compared to the traditional MSP. M
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47

Meral, Nursel, Fatih Şen, and Enes Yılmaz. "‘Farfia’ Kayısı Meyvelerinin Depolanabilirliğine Modifiye Atmosfer Paketleme ve 1-Metilsiklopropen Uygulamalarının Etkilerinin Belirlenmesi." Turkish Journal of Agriculture - Food Science and Technology 12, s1 (2024): 2060–68. https://doi.org/10.24925/turjaf.v12is1.2060-2068.7034.

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Bu çalışmada, modifiye atmosfer paketleme (MAP) ve 1-metilsiklopropen (1-MCP) ‘Farfia’ kayısı çeşidi meyvelerinin hasat sonrası dayanımlarına etkilerinin belirlenmesi amaçlanmıştır. Çalışma; a) Kontrol, b) MAP, c) 1-MCP, d) MAP + 1-MCP, e) RipeLock™ MAP ambalaj + 1-MCP olacak şekilde beş farklı uygulama gerçekleştirilmiştir. 1-MCP, 24 saat 625 ppb olarak uygulanmıştır. ‘Farfia’ kayısı çeşidine ait meyveler 8 hafta süreyle 0°C’de %90 nemde depolanmıştır. Depolama öncesi ve süresince 2 haftalık periyotlarla alınan örneklerde ambalajların ağzı açılarak 2 gün raf ömründe (20°C) bekletildikten sonr
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48

Dekkers, Pascale E. P., Marcel Levi, Sander J. H. van Deventer та Tom van der Poll. "Divergent Roles of Tumor Necrosis Factor and Platelet-Activating Factor in Endotoxin-Induced Release of Monocyte Chemoattractant Protein 1 and Macrophage Inflammatory Protein 1β in Chimpanzees". Infection and Immunity 67, № 10 (1999): 5480–82. http://dx.doi.org/10.1128/iai.67.10.5480-5482.1999.

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ABSTRACT A platelet-activating factor receptor antagonist reduced the release of macrophage inflammatory protein 1β (MIP-1β) during endotoxemia in chimpanzees but did not influence the secretion of monocyte chemoattractant protein 1 (MCP-1). Anti-tumor necrosis factor alpha monoclonal antibody completely prevented MCP-1 release and simultaneously enhanced the secretion of MIP-1β. Levels of MIP-1β and MCP-1 release were differentially regulated during endotoxemia.
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49

Bizzarri, C., R. Bertini, P. Bossu, et al. "Single-cell analysis of macrophage chemotactic protein-1-regulated cytosolic Ca2+ increase in human adherent monocytes." Blood 86, no. 6 (1995): 2388–94. http://dx.doi.org/10.1182/blood.v86.6.2388.bloodjournal8662388.

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The increase in intracellular free Ca2+ ([Ca2+]i) associated with interaction of monocyte chemotactic protein-1 (MCP-1) and related chemokines beta with adherent human blood monocytes was investigated at the single-cell level. We used f-MLP as reference chemotactic agent. MCP-1 caused an increase in [Ca2+]i in individual adherent monocytes, with 95% of cells responding to the chemokine at 20 ng/mL. Response to MCP-1 was already detectable at 1 pg/mL, whereas at least 5 ng/mL were required for significant chemotactic response. The kinetics of the increase in [Ca2+]i were considerably different
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50

Sabir, Ferhan K. "Postharvest quality response of broccoli florets to combined application of 1-methylcyclopropene and modified atmosphere packaging." Agricultural and Food Science 21, no. 4 (2012): 421–29. http://dx.doi.org/10.23986/afsci.6387.

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Broccoli is rich in health-promoting compounds such as ascorbic acid and glucosinolates. However, amount of such compounds inevitably decrease along with the storage. This study was conducted to investigate the effects of 1-methylcyclopropene (1-MCP) and Modified Atmosphere Packaging (MAP) treatments alone or in combination on postharvest life and quality of broccoli heads during cold storage. MAP and 1-MCP+MAP significantly reduced weight loss, delayed surface color changes and chlorophyll breakdown, maintained visual quality, ascorbic acid, total phenol, soluble solid contents and titratable
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