To see the other types of publications on this topic, follow the link: M-DCM.
Journal articles on the topic 'M-DCM'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'M-DCM.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Vogelgsang, Lars, Azlan Nisar, Sebastian Alexander Scharf, et al. "Characterisation of Type II DNA Methyltransferases of Metamycoplasma hominis." Microorganisms 11, no. 6 (2023): 1591. http://dx.doi.org/10.3390/microorganisms11061591.
Full textAbstract:
Bacterial virulence, persistence and defence are affected by epigenetic modifications, including DNA methylation. Solitary DNA methyltransferases modulate a variety of cellular processes and influence bacterial virulence; as part of a restriction-modification (RM) system, they act as a primitive immune system in methylating the own DNA, while unmethylated foreign DNA is restricted. We identified a large family of type II DNA methyltransferases in Metamycoplasma hominis, comprising six solitary methyltransferases and four RM systems. Motif-specific 5mC and 6mA methylations were identified with a tailored Tombo analysis on Nanopore reads. Selected motifs with methylation scores >0.5 fit with the gene presence of DAM1 and DAM2, DCM2, DCM3, and DCM6, but not for DCM1, whose activity was strain-dependent. The activity of DCM1 for CmCWGG and of both DAM1 and DAM2 for GmATC was proven in methylation-sensitive restriction and finally for recombinant rDCM1 and rDAM2 against a dam-, dcm-negative background. A hitherto unknown dcm8/dam3 gene fusion containing a (TA) repeat region of varying length was characterized within a single strain, suggesting the expression of DCM8/DAM3 phase variants. The combination of genetic, bioinformatics, and enzymatic approaches enabled the detection of a huge family of type II DNA MTases in M. hominis, whose involvement in virulence and defence can now be characterized in future work.
2
Li, Gang, Qiang Lin, Guangyan Ni, et al. "Vertical Patterns of Early Summer Chlorophyll a Concentration in the Indian Ocean with Special Reference to the Variation of Deep Chlorophyll Maximum." Journal of Marine Biology 2012 (2012): 1–6. http://dx.doi.org/10.1155/2012/801248.
Full textAbstract:
Vertical patterns of early summer chlorophylla(Chla) concentration from the Indian Ocean are presented, as well as the variations of depth and size-fractioned Chlain the deep chlorophyll maximum (DCM). A total of 38 stations were investigated from 12 April to 5 May 2011, with 8 discrete-depth samples (7 fixed and 1 variable at real DCM) measured at each station. Depth-integrated Chlaconcentration (∑Chl a) varied from 11.5 to 26.8 mg m−2, whereas Chlacontent at DCM ranged from 0.17 to 0.57 μg L−1with picophytoplankton (<3 μm) accounting for 82% to 93%. The DCM depth varied from 55.6 to 91 m and shoaled latitudinally to northward. Moreover, our results indicated that the∑Chl acould be underestimated by up to 9.3% with a routine sampling protocol of collecting samples only at 7 fixed depths as the real DCM was missed. The underestimation was negatively correlated to the DCM depth when it varied from 55.6 to 71.3 m (r=−0.63,P<0.05) but positively correlated when it ranged from 75.8 to 91 m (r=0.68,P<0.01). This indicates that in the Indian Ocean the greater the departure of the DCM from 75 m depth, the greater the underestimation of integrated Chlaconcentration that could occur if the real DCM is missed.
3
Liao, Hai-han, Jin-xiu Zhu, Hong Feng та ін. "Myricetin Possesses Potential Protective Effects on Diabetic Cardiomyopathy through Inhibiting IκBα/NFκB and Enhancing Nrf2/HO-1". Oxidative Medicine and Cellular Longevity 2017 (2017): 1–14. http://dx.doi.org/10.1155/2017/8370593.
Full textAbstract:
Diabetic cardiomyopathy (DCM) is associated with a greater risk of mortality in patients with diabetes mellitus. Currently, no specific treatment has been suggested for DCM treatment. This study demonstrated that myricetin (M) attenuated DCM-associated cardiac injury in mice subjected to streptozotocin (SZT) and in neonatal rat cardiomyocytes (NRCM) challenged with high glucose.In vivoinvestigation demonstrated 6 months of M treatment (200 mg/kg/d) significantly alleviated cardiac hypertrophy, apoptosis, and interstitial fibrosis. Mechanically, M treatment significantly increased the activity of Nrf2/HO-1 pathway, strengthening antioxidative stress capacity evidenced by reversed activities of GPx and SOD, and decreased MDA production. M treatment also inhibited IκBα/NF-κB pathway, resulting in reduced secretion of inflammation cytokines including IL-1β, TNF-α, and IL-6. Besides, the TGFβ/Smad3 signaling was also blunted in DCM mice treated with M. These beneficial effects of M treatment protected cardiomyocytes from apoptosis as shown by decreased TUNEL-positive nucleus, c-caspase 3, and Bax. Similar effects of M treatment could be reproduced in NRCM treated with high glucose. Furthermore, through silencing Nrf2 in NRCM, we found that the regulation of IκBα/NFκB by M was independent on its function on Nrf2. Thus, we concluded that M possesses potential protective effects on DCM through inhibiting IκBα/NFκB and enhancing Nrf2/HO-1.
4
Kalsi-Ryan, Sukhvinder, Lauren E. Riehm, Lindsay Tetreault, et al. "Characteristics of Upper Limb Impairment Related to Degenerative Cervical Myelopathy: Development of a Sensitive Hand Assessment (Graded Redefined Assessment of Strength, Sensibility, and Prehension Version Myelopathy)." Neurosurgery 86, no. 3 (2019): E292—E299. http://dx.doi.org/10.1093/neuros/nyz499.
Full textAbstract:
Abstract BACKGROUND Degenerative cervical myelopathy (DCM) involves spinal cord compression, which causes neurological decline. Neurological impairment in DCM is variable and can involve complex upper limb dysfunction including loss of manual dexterity, hyperreflexia, focal weakness, and sensory impairment. The modified Japanese Orthopaedic Association (mJOA) score relies on the patients’ subjective perceptions, whereas existing objective measures such as strength and sensory testing do not capture subtle changes in dexterity and function. OBJECTIVE 1) To characterize arm and hand function in DCM; and 2) To develop and validate Graded Redefined Assessment of Strength, Sensibility, and Prehension Version-Myelopathy (GRASSP-M), a clinical assessment that quantifies upper limb impairment. METHODS A total of 148 DCM patients (categorized into mild, moderate, and severe based on mJOA grade) and 21 healthy subjects were enrolled. A complete neurological exam, the mJOA, the QuickDASH, grip dynamometry, and the GRASSP-M were administered. RESULTS Strength, sensation, and manual dexterity significantly declined with increasing DCM severity (P ≤ .05). Impairment in hand dexterity showed better discrimination between mild, moderate, and severe DCM categories than strength or sensation. The GRASSP-M was found to be both a reliable (intraclass correlation coefficient &gt;0.75 for intra- and inter-rater reliability) and valid (with both concurrent and construct validity) tool. CONCLUSION These results demonstrate that patients’ subjective reporting of functional status, especially in the mild DCM category, may underrepresent the extent of functional impairment. The GRASSP-M is an objective tool designed to characterize patients’ functional impairment related to the upper limb, which proves useful to diagnose and quantify mild dysfunction, monitor patients for deterioration, and help determine when patients should be treated surgically.
5
Rahman, Mohammad Azizur, Noorlidah Abdullah, and Norhaniza Aminudin. "Antioxidative Effects and Inhibition of Human Low Density Lipoprotein OxidationIn Vitroof Polyphenolic Compounds inFlammulina velutipes(Golden Needle Mushroom)." Oxidative Medicine and Cellular Longevity 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/403023.
Full textAbstract:
Dietary polyphenolic compounds mediate polynomial actions in guarding against multiple diseases. Atherosclerosis is an oxidative stress driven pathophysiological complication where free radical induced oxidative modification of low density lipoprotein (LDL) plays the ground breaking role. Mushrooms have been highly regarded for possessing an antioxidant arsenal. Polyphenolic compounds present in dietary mushrooms seem pertinent in withstanding LDL oxidation en route to controlling atherosclerosis. In this study, the antioxidative effect of five solvent fractions consisting of methanol : dichloromethane (M : DCM), hexane (HEX), dichloromethane (DCM), ethyl acetate (EA), and aqueous residue (AQ) ofFlammulina velutipeswas evaluated. M : DCM fraction showed the most potent 2,2-diphenyl-1-picrylhydrazyl radical scavenging effect with IC50of 0.86 mg/mL and total phenolic content of 56.36 gallic acid equivalent/g fraction. In LDL oxidation inhibitory tests, M : DCM fraction at 1 µg/mL concentration mostly lengthened the lag time (125 mins) of conjugated diene formation and inhibited the formation of thiobarbituric acid reactive substances (48.71%, at 1 mg/mL concentration). LC-MS/MS analyses of M : DCM fraction identified the presence of polyphenolic substances protocatechuic acid,p-coumaric, and ellagic acid. These chain-breaking polyphenolics might impart the antioxidative effects ofF. velutipes. Thus, mushroom-based dietary polyphenolic compounds might be implicated in slowing down the progression of atherosclerosis.
6
Krumm, Patrick, Jan M. Brendel, Karin Klingel, et al. "Using Multiparametric Cardiac Magnetic Resonance to Phenotype and Differentiate Biopsy-Proven Chronic from Healed Myocarditis and Dilated Cardiomyopathy." Journal of Clinical Medicine 11, no. 17 (2022): 5047. http://dx.doi.org/10.3390/jcm11175047.
Full textAbstract:
(1) Objectives: To discriminate biopsy-proven myocarditis (chronic vs. healed myocarditis) and to differentiate from dilated cardiomyopathy (DCM) using cardiac magnetic resonance (CMR). (2) Methods: A total of 259 consecutive patients (age 51 ± 15 years; 28% female) who underwent both endomyocardial biopsy (EMB) and CMR in the years 2008–2021 were evaluated. According to right-ventricular EMB results, patients were divided into either chronic (n = 130, 50%) or healed lymphocytic myocarditis (n = 60, 23%) or DCM (n = 69, 27%). The CMR protocol included functional, strain, and late gadolinium enhancement (LGE) imaging, T2w imaging, and T2 mapping. (3) Results: Left-ventricular ejection fraction (LV-EF) was higher, and the indexed end-diastolic volume (EDV) was lower in myocarditis patients (chronic: 42%, median 96 mL/m²; healed: 49%, 86 mL/m²) compared to the DCM patients (31%, 120 mL/m²), p < 0.0001. Strain analysis demonstrated lower contractility in DCM patients vs. myocarditis patients, p < 0.0001. Myocarditis patients demonstrated a higher LGE prevalence (68% chronic; 59% healed) than the DCM patients (45%), p = 0.01. Chronic myocarditis patients showed a higher myocardial edema prevalence and ratio (59%, median 1.3) than healed myocarditis (23%, 1.3) and DCM patients (13%, 1.0), p < 0.0001. T2 mapping revealed elevated values more frequently in chronic (90%) than in healed (21%) myocarditis and DCM (23%), p < 0.0001. T2 mapping yielded an AUC of 0.89 (sensitivity 90%, specificity 76%) in the discrimination of chronic from healed myocarditis and an AUC of 0.92 (sensitivity 86%, specificity 91%) in the discrimination of chronic myocarditis from DCM, both p < 0.0001. (4) Conclusions: Multiparametric CMR imaging, including functional parameters, LGE and T2 mapping, may allow differentiation of chronic from healed myocarditis and DCM and therefore help to optimize patient management in this clinical setting.
7
Voottipruex, P., D. T. Bergado, T. Suksawat, and P. Jamsawang. "Numerical Simulations and Full Scale Behavior of SDCM and DCM Piles on Soft Bangkok Clay." Soils and Rocks 34, no. 4 (2011): 317–30. http://dx.doi.org/10.28927/sr.344317.
Full textAbstract:
A new kind of reinforced Deep Cement Mixing (DCM) pile, namely: Stiffened Deep Cement Mixing (SDCM) pile is introduced to mitigate the problems due to the low flexural resistance, lack of quality control in the field and unexpected failure of DCM pile. The SDCM pile consists of DCM pile reinforced with precast concrete core pile. Previously, the full scale embankment loading test on soft Bangkok clay improved by SDCM and DCM piles was successfully conducted and monitored. The parameters were also derived from an earlier full scale load tests to failures and subsequent simulations. To continue the study on the behavior of SDCM and DCM piles, the 3D finite element simulations and parametric study have been done. The simulation results of the full scale embankment loading test indicated that the surface settlements decreased with increasing lengths of the concrete core piles from 4 to 6 m but slightly reduced from 6 to 7 m as well as slightly decreased with increasing sectional areas in the SDCM piles. In addition, the lateral movements of the embankment decreased by increasing the lengths (longer than 4 m) and, to a lesser degree, the sectional areas of the concrete core piles in the SDCM piles. The results of the numerical simulations closely agreed with the observed data from full scale field tests and successfully verified the parameters affecting the performances and behavior of both SDCM and DCM piles.
8
Chen, B., L. Zheng, B. Huang, S. Song, and H. Liu. "Seasonal and spatial comparisons of phytoplankton growth and mortality rates due to microzooplankton grazing in the northern South China Sea." Biogeosciences 10, no. 4 (2013): 2775–85. http://dx.doi.org/10.5194/bg-10-2775-2013.
Full textAbstract:
Abstract. We conducted a comprehensive investigation on the microzooplankton herbivory effect on phytoplankton in the northern South China Sea (SCS) using the seawater dilution technique at surface and deep chlorophyll maximum (DCM) layers on two cruises (July–August of 2009 and January of 2010). We compared vertical (surface vs. DCM), spatial (onshore vs. offshore), and seasonal (summer vs. winter) differences of phytoplankton growth (μ0) and microzooplankton grazing rates (m). During summer, both μ0 and m were significantly higher at the surface than at the DCM layer, which was below the mixed layer. During winter, surface μ0 was significantly higher than at the DCM, while m was not significantly different between the two layers, both of which were within the mixed layer. Surface μ0 was, on average, significantly higher in summer than in winter, while average surface m was not different between the two seasons. There were no cross-shelf gradients of μ0 in summer or winter surface waters. In surface waters, μ0 was not correlated with ambient nitrate concentrations, and the effect of nutrient enrichment on phytoplankton growth was not pronounced. There was a decreasing trend of m from shelf to basin surface waters in summer, but not in winter. Microzooplankton grazing effect on phytoplankton (m/μ0) was relatively small in the summer basin waters, indicating a decoupling of microzooplankton grazing and phytoplankton growth at this time. On average, microzooplankton grazed 73% and 65% of the daily primary production in summer and winter, respectively.
9
Lee, Haksung, Seok-Jae Kim, Bang-Hun Kang, and Kwang-Seung Lee. "Long-Term Settlement Prediction of Ground Reinforcement Foundation Using a Deep Cement Mixing Method in Reclaimed Land." Buildings 12, no. 8 (2022): 1279. http://dx.doi.org/10.3390/buildings12081279.
Full textAbstract:
The greenhouse foundation method requires a lower allowable bearing capacity compared to general buildings, but the high-spec and expensive prestressed high-strength concrete (PHC) pile reinforcement method is mainly applied. Therefore, the deep cement mixing (DCM) method, which is one of the ground reinforcement foundations that replaces the PHC piles and secures structural safety suitable for the greenhouse foundation, was considered. To verify the structural safety of the DCM method, a geotechnical survey and soil test were conducted, and a long-term settlement monitoring system was established. The specifications of the DCM foundation were designed to be 0.8 m in diameter, 3 m × 3 m in width and length, and 3 m in depth. Based on the settlement monitoring data, long-term settlement was predicted considering the greenhouse durability of 15 years. For long-term settlement prediction, the Log S–T, hyperbolic, Asaoka method, Schmertmann theory, and the finite element method (FEM) analysis were performed. In the case of the Log S–T, hyperbolic, and Asaoka method based on actual measurement data, the settlement amount was predicted to be 12.18~20.43 mm, and in the case of the Schmertmann empirical formula, it was predicted to be 19.66 m. The FEM analysis result was 8.89 mm. As the most conservative result, the DCM foundation method designed in this paper had an allowable bearing capacity of 310 kN/m2 and a long-term settlement of 20.43 mm. This is the result of satisfying both the allowable bearing capacity of 100 kN/m2 and the allowable settlement range of 25.4 mm as a foundation. Through this study, it was proven that long-term structural safety can be sufficiently secured when the DCM foundation is constructed on a soft ground through a design that considers the required service life and allowable bearing capacity of the structure. In addition, it was confirmed that the Hyperbolic, Asaoka, and FEM analysis method adopted in this paper can be applied to the long-term settlement behavior analysis of the DCM foundation method.
10
Rokstad, Anne Marie Mork, and Solfrid Vatne. "Dementia care mapping – en mulig metode for utvikling av demensomsorg i sykehjem." Nordisk tidsskrift for helseforskning 5, no. 2 (2009): 46. http://dx.doi.org/10.7557/14.239.
Full textAbstract:
<p>Artikkelen omhandler en studie av Dementia Care Mapping (DCM) anvendt i et norsk sykehjem. Hensikten med studien var &aring; unders&oslash;ke om det skjer et perspektivskifte i personalgruppen ved bruk av DCM-metoden, og om dette f&aring;r konsekvenser for praksis. I studien inngikk fokusgruppeintervju med personalet i sykehjemsavdelingen. Bakgrunnsopplysningene som sykepleierne reflekterte over, var kartlegging av trivsel og velv&aelig;re hos pasientene innsamlet gjennom DCM-metoden, og meldt tilbake til personalet. Personalet opplevde at tilbakemeldingene f&oslash;rte til &oslash;kt bevissthet i samhandling med pasientene. If&oslash;lge deres utsagn medf&oslash;rte prosjektet flere konkrete endringer i m&aring;ten de m&oslash;tte pasientene p&aring;. Kartleggingen foretatt etter tre m&aring;neder viste st&oslash;rre grad av trivsel og velv&aelig;re i pasientgruppen. Dette peker i retning av at DCM kan v&aelig;re en nyttig metode for kvalitetsutvikling av demensomsorgen i sykehjem. Det er imidlertid behov for videre forskning med et strammere design og et st&oslash;rre utvalg for &aring; bekrefte funnene.</p>
11
Ninčević, Živana, Ivona Marasović, and Grozdan Kušpilić. "Deep chlorophyll-a maximum at one station in the middle Adriatic Sea." Journal of the Marine Biological Association of the United Kingdom 82, no. 1 (2002): 9–19. http://dx.doi.org/10.1017/s0025315402005131.
Full textAbstract:
Deep or subsurface chlorophyll-a maximum (DCM) was studied at one station in the middle Adriatic from December 1996 to June 1998. Chlorophyll-a concentration, abundance, volume carbon concentration, size-fraction of phytoplankton and phytoplankton community structure were determined. In addition, physical and chemical factors as well as nutrients were determined. The DCM occurs during both the vertical mixing and stratification period in the middle Adriatic Sea. It is most frequent between 50 and 75 m. It is located below the pycnocline and it is associated with the nutricline. Phytoplankton size-fraction and community structure vary seasonally. The DCM is most pronounced during spring phytoplankton blooms with diatom dominance. Procaryotic picoplankton Synechococcus sp. was abundant in DCM during summer stratification. The DCM represents both a biomass maximum and a phytoplankton adaptation to low irradiance.
12
Chen, B., L. Zheng, B. Huang, S. Song, and H. Liu. "Seasonal and spatial comparisons of phytoplankton growth and mortality rates due to microzooplankton grazing in the northern South China Sea." Biogeosciences Discussions 9, no. 11 (2012): 16005–32. http://dx.doi.org/10.5194/bgd-9-16005-2012.
Full textAbstract:
Abstract. We conducted a comprehensive investigation on the microzooplankton herbivory effect on phytoplankton in the northern South China Sea (SCS) using the seawater dilution technique at surface and deep chlorophyll maximum (DCM) layers in two cruises (July–August of 2009 and January of 2010). We compared vertical (surface vs. DCM), spatial (onshore vs. offshore), and seasonal (summer vs. winter) differences of phytoplankton growth (μ0) and microzooplankton grazing rates (m). During summer, both μ0 and m were significantly higher at the surface than at the layer of DCM, which was below the mixed layer. During winter, surface μ0 was significantly higher than at DCM, while m was not significantly different between the two layers, both of which were contained within the mixed layer. Surface μ0 was, on average, significantly higher in summer than in winter; while average surface m was not different between the two seasons. There were no significant cross-shelf trends of μ0 in summer or winter surface waters. In surface waters, μ0 was not correlated with ambient nitrate concentrations and the effect of nutrient enrichment on phytoplankton growth was not pronounced. There was a decreasing trend of m from shelf to basin surface waters in summer, but not in winter. Microzooplankton grazing effect on phytoplankton (m/μ0) did not increase with distance offshore, suggesting that the importance of microzooplankton as grazers of phytoplankton may not decrease in onshore waters. On average, microzooplankton grazed 73% and 65% of the daily primary production in summer and winter, respectively.
13
Ricour, Florian, Arthur Capet, Fabrizio D'Ortenzio, Bruno Delille, and Marilaure Grégoire. "Dynamics of the deep chlorophyll maximum in the Black Sea as depicted by BGC-Argo floats." Biogeosciences 18, no. 2 (2021): 755–74. http://dx.doi.org/10.5194/bg-18-755-2021.
Full textAbstract:
Abstract. The deep chlorophyll maximum (DCM) is a well-known feature of the global ocean. However, its description and the study of its formation are a challenge, especially in the peculiar environment that is the Black Sea. The retrieval of chlorophyll a (chl a) from fluorescence (Fluo) profiles recorded by Biogeochemical Argo (BGC-Argo) floats is not trivial in the Black Sea, due to the very high content of coloured dissolved organic matter (CDOM) which contributes to the fluorescence signal and produces an apparent increase in the chl a concentration with depth. Here, we revised Fluo correction protocols for the Black Sea context using co-located in situ high-performance liquid chromatography (HPLC) and BGC-Argo measurements. The processed set of chl a data (2014–2019) is then used to provide a systematic description of the seasonal DCM dynamics in the Black Sea and to explore different hypotheses concerning the mechanisms underlying its development. Our results show that the corrections applied to the chl a profiles are consistent with HPLC data. In the Black Sea, the DCM begins to form in March, throughout the basin, at a density level set by the previous winter mixed layer. During a first phase (April–May), the DCM remains attached to this particular layer. The spatial homogeneity of this feature suggests a hysteresis mechanism, i.e. that the DCM structure locally influences environmental conditions rather than adapting instantaneously to external factors. In a second phase (July–September), the DCM migrates upward, where there is higher irradiance, which suggests the interplay of biotic factors. Overall, the DCM concentrates around 45 % to 65 % of the total chlorophyll content within a 10 m layer centred around a depth of 30 to 40 m, which stresses the importance of considering DCM dynamics when evaluating phytoplankton productivity at basin scale.
14
Kadanka, Zdenek, Zdenek Kadanka, Tomas Skutil, Eva Vlckova, and Josef Bednarik. "Walk and Run Test in Patients with Degenerative Compression of the Cervical Spinal Cord." Journal of Clinical Medicine 10, no. 5 (2021): 927. http://dx.doi.org/10.3390/jcm10050927.
Full textAbstract:
Impaired gait is one of the cardinal symptoms of degenerative cervical myelopathy (DCM) and frequently its initial presentation. Quantitative gait analysis is therefore a promising objective tool in the disclosure of early cervical cord impairment in patients with degenerative cervical compression. The aim of this cross-sectional observational cohort study was to verify whether an objective and easily-used walk and run test is capable of detecting early gait impairment in a practical proportion of non-myelopathic degenerative cervical cord compression (NMDCC) patients and of revealing any correlation with severity of disability in DCM. The study group consisted of 45 DCM patients (median age 58 years), 126 NMDCC subjects (59 years), and 100 healthy controls (HC) (55.5 years), all of whom performed a standardized 10-m walk and run test. Walking/running time/velocity, number of steps and cadence of walking/running were recorded; analysis disclosed abnormalities in 66.7% of NMDCC subjects. The DCM group exhibited significantly more pronounced abnormalities in all walk/run parameters when compared with the NMDCC group. These were apparent in 84.4% of the DCM group and correlated closely with disability as quantified by the modified Japanese Orthopaedic Association scale. A standardized 10-m walk/run test has the capacity to disclose locomotion abnormalities in NMDCC subjects who lack other clear myelopathic signs and may provide a means of classifying DCM patients according to their degree of disability.
15
Srivastava, Mukesh K., Anil Ahuja, R. D. Velhankar, Ashish Srivastav, Barkha Sharma, and Arpana Raikwar. "Echocardiographic Alterations of Dilated Cardiomyopathy in Dogs." UTTAR PRADESH JOURNAL OF ZOOLOGY 45, no. 14 (2024): 222–31. http://dx.doi.org/10.56557/upjoz/2024/v45i144198.
Full textAbstract:
An extensive investigation involving 2497 dogs aimed to determine the prevalence of Dilated Cardiomyopathy (DCM). Through meticulous examination incorporating historical, clinical, electrocardiographic, and radiographic analyses, 29 cases were definitively diagnosed with DCM using echocardiography. Employing advanced echocardiographic technology, including 2-D imaging with M-mode and Doppler modalities, precise cardiac assessments were conducted. Attention to standard imaging planes and thoracic depilation ensured optimal transducer adherence. Comparative analysis between healthy and DCM-affected dogs revealed significant differences in left atrial dimensions, indicative of pathological cardiac remodeling. Furthermore, notable variations in ventricular dimensions and functional indices were observed, reflecting impaired myocardial contractility and ventricular compliance, particularly in cases with right-sided involvement. Doppler assessments unveiled aberrant blood flow dynamics in DCM, indicating hemodynamic disturbances. These findings underscore the diagnostic utility and pathophysiological insights provided by echocardiography in characterizing DCM pathology in dogs. In conclusion, echocardiography emerges as a valuable tool for the comprehensive evaluation and diagnosis of DCM in canine patients, facilitating early detection and effective management of this debilitating cardiac condition.
16
Kondoju, Sai Krishna, and V. V. Mani. "Outage and BER analysis of dual-carrier modulation over frequency-selective Nakagami-m fading channels." COMPEL - The international journal for computation and mathematics in electrical and electronic engineering 36, no. 1 (2017): 90–107. http://dx.doi.org/10.1108/compel-03-2016-0097.
Full textAbstract:
Purpose This paper aims to the increasing need for high-speed low-power data transmissions over frequency-selective fading channels has drawn attention to suggest dual-carrier modulation (DCM) for multiband orthogonal frequency division multiplexing (OFDM) transceivers for ultra wideband (UWB) wireless personal area network (WPAN). Design/methodology/approach Under frequency-selective fading channel conditions, the decoder is not sufficient enough to decode the transmission bits of severely attenuated data tones. Hence, the authors suggest DCM for a multiband OFDM transceiver because of its multiple capability of providing both frequency diversity and coding gain. It also resulted in low bit-error-rate (BER) at a given signal- to-noise ratio when compared to conventional multiband OFDM system. To achieve an optimised BER, DCM transforms four re-ordered bits into two quaternary phase shift keying symbols and further transforms to two 16-quadrature amplitude modulation-like (16-QAM) symbols with a suitable mapping technique, and at the receiver end, they are decoded with maximum likelihood decision rule. After performing the transformation, the outage probability and average BER expressions are derived to analyse the system performance. Findings DCM is suitable for high data rate transmission and is immune to frequency-selective fading. The outage and BER performance outstands over conventional multiband OFDM transceiver because of the inclusion of DCM mapping. Practical implications It is widely used in WPANs such as high definition multimedia interface and wireless universal serial bus. Originality/value This paper derives novel closed-form outage probability and a tight upper bound on average BER expressions for DCM-based multiband OFDM UWB transceiver over frequency-selective Nakagami-m fading channels for any arbitrary value of m. For this, moment-generating function of sum of squared, independent and identically distributed (i.i.d.) Nakagami-m random variables are used. Further, the system performance is also validated for the case of exponential decaying power delay profile, and the simulation results are provided to check the accuracy of the derived expressions.
17
Zhu, Run Ye, Hong Xia Liu, Dong Zhi Chen, Jian Meng Chen, and Zhe Ning Sun. "The Cultivation of Methylobactreium rhodesianum H13 for Dichloromethane Degradation." Advanced Materials Research 482-484 (February 2012): 1390–93. http://dx.doi.org/10.4028/www.scientific.net/amr.482-484.1390.
Full textAbstract:
Dichloromethane (DCM) is a toxic pollutant with prolonged persistence in air and water. The work focused on the cultivation of Methylobacterium rhodesiaum H13 which could utilize DCM as the sole carbon source. By comparison and analysis, R2A was chosen as the suitable culture medium for large-scale cultivation. Furthermore, the optimized composition of medium was established on the basis of biomass obtained and the DCM degradation activity of M. rhodesiaum H13, which contained yeast extract 1.5 g/L, peptone 1.5 g/L, glucose 1.5 g/L, sodium pyruvate 0.9 g/L, K2HPO4 0.9 g/L and MgSO4•H2O 0.15 g/L.
18
Knoche, Moritz, Peter D. Petracek, Martin J. Bukovac, and Warren E. Shafer. "Urea Penetration of Isolated Tomato Fruit Cuticles." Journal of the American Society for Horticultural Science 119, no. 4 (1994): 761–64. http://dx.doi.org/10.21273/jashs.119.4.761.
Full textAbstract:
14C-urea penetration of isolated tomato (Lycopersicon esculentum Mill. cv. `Pik Red') fruit cuticular membranes (CM) was studied as a function of concentration and temperature. There was no significant effect of cuticular wax on urea penetration at 25C, permeances for the CM being 8.4 × 10-10 and dewaxed CM (DCM) 11.1 × 10-10·m·s-1. Time lags were near zero for both CM and DCM. Steady-state diffusion analysis suggests that the relatively low cuticular permeance of urea is due to low partitioning that offsets high diffusivity. Urea flux through the CM and DCM showed ≈1.5- and 1.9-fold increases, respectively, for each 10C increase between 5 and 45C. Urea flux across CM and DCM increased linearly with concentration (10 μm to 1 m) and, thus, was a first-order process.
19
Kalsi-Ryan, Sukhvinder, Anna C. Rienmueller, Lauren Riehm, et al. "Quantitative Assessment of Gait Characteristics in Degenerative Cervical Myelopathy: A Prospective Clinical Study." Journal of Clinical Medicine 9, no. 3 (2020): 752. http://dx.doi.org/10.3390/jcm9030752.
Full textAbstract:
It is challenging to discriminate the early presentation of Degenerative Cervical Myelopathy (DCM) as well as sensitively and accurately distinguishing between mild, moderate, and severe levels of impairment. As gait dysfunction is one of the cardinal symptoms of DCM, we hypothesized that spatiotemporal gait parameters, including the enhanced gait variability index (eGVI), could be used to sensitively discriminate between different severities of DCM. A total of 153 patients recently diagnosed with DCM were recruited and stratified on the basis of DCM severity grades, as measured using the modified Japanese Orthopedic Association (mJOA) scale. Demographic information and neurological status were collected. Gait assessments were performed using an 8 m walkway. Spearman rank correlation was used to identify relationships between gait parameters and mJOA values as well as the mJOA lower extremity (LE) subscore. Kruskal–Wallis H test was performed to evaluate differences between severity groups, as defined by mJOA classification. A significant and relatively strong correlation was found between the mJOA score and eGVI, as well as between the LE subscore of the mJOA and eGVI. Significant differences in the eGVI (X2(2, N = 153) = 55.04, p < 0.0001, ε2 = 0.36) were found between all groups of DCM severity, with a significant increase in the eGVI as DCM progressed from mild to moderate. The eGVI was the most discriminative gait parameter, which facilitated objective differentiation between varying severities of DCM. Quantitative gait assessments show promise as an accurate and objective tool to diagnose and classify DCM, as well as to potentially evaluate the impact of therapeutic interventions.
20
Waas, Harold J. D., Simon Tubalawony, and Ronald D. Hukubun. "Kedalaman Klorofil Maksimum Selama Musim Peralihan II dan Implikasinya untuk Perikanan Tuna di Laut Banda." Jurnal Laut Pulau: Hasil Penelitian Kelautan 2, no. 1 (2023): 1–14. http://dx.doi.org/10.30598/jlpvol2iss1pp1-14.
Full textAbstract:
The Deep chlorophyll maximum (DCM) in the Banda Sea during the second transitional season (October 2015) was relatively shallow (25 - 64 m) above the mixed layer and far from the base of the euphotic layer or compensation depth. Its presence was identical to the depth of nitraclin injected into the mixed layer as a result of upwelling generated by internal waves. The contribution of these waves to the increase in Banda Sea fertility calculated using ocean color data is 56.87%. This phenomenon is due to the shallow optical depth of the satellite (20-25 m) while high chlorophyll-a concentrations are below. DCM was also associated with the swimming layer of Madidihang (Thunnus albacares) (34 - 68 m) caught with longline gear during the same period.
21
Varaljay, Vanessa A., Scott M. Gifford, Samuel T. Wilson, Shalabh Sharma, David M. Karl, and Mary Ann Moran. "Bacterial Dimethylsulfoniopropionate Degradation Genes in the Oligotrophic North Pacific Subtropical Gyre." Applied and Environmental Microbiology 78, no. 8 (2012): 2775–82. http://dx.doi.org/10.1128/aem.07559-11.
Full textAbstract:
ABSTRACTDimethylsulfoniopropionate (DMSP) is an organic sulfur compound that is rapidly metabolized by marine bacteria either by cleavage to dimethylsulfide (DMS) or demethylation to 3-methiolpropionate. The abundance and diversity of genes encoding bacterial DMS production (dddP) and demethylation (dmdA) were measured in the North Pacific subtropical gyre (NPSG) between May 2008 and February 2009 at Station ALOHA (22°45′N, 158°00′W) at two depths: 25 m and the deep chlorophyll maximum (DCM; ∼100 m). The highest abundance ofdmdAgenes was in May 2008 at 25 m, with ∼16.5% of cells harboring a gene in one of the eight subclades surveyed, while the highest abundance ofdddPgenes was in July 2008 at 25 m, with ∼2% of cells harboring a gene. ThedmdAgene pool was consistently dominated by homologs from SAR11 subclades, which was supported by findings in metagenomic data sets derived from Station ALOHA. Expression of the SAR11dmdAgenes was low, with typical transcript:gene ratios between 1:350 and 1:1,400. The abundance of DMSP genes was statistically different between 25 m and the DCM and correlated with a number of environmental variables, including primary production, photosynthetically active radiation, particulate DMSP, and DMS concentrations. At 25 m,dddPabundance was positively correlated with pigments that are diagnostic of diatoms; at the DCM,dmdAabundance was positively correlated with temperature. Based on gene abundance, we hypothesize that SAR11 bacterioplankton dominate DMSP cycling in the oligotrophic NPSG, with lesser but consistent involvement of other members of the bacterioplankton community.
22
Shortreed, Ken S., and John G. Stockner. "Effect of Nutrient Additions on Lower Trophic Levels of an Oligotrophic Lake with a Seasonal Deep Chlorophyll Maximum." Canadian Journal of Fisheries and Aquatic Sciences 47, no. 2 (1990): 262–73. http://dx.doi.org/10.1139/f90-029.
Full textAbstract:
Inorganic nitrogen and phosphorus were added to the surface of selected areas of Sproat Lake, Vancouver Island, British Columbia for varying periods in 1985 and 1986. The lake is monomictic, oligotrophic, and for much of each year has a deep chlorophyll maximum (DCM) located near the bottom of the euphotic zone (20–25 m). Epilimnetic chlorophyll concentrations are low (ca. 0.5 μg∙L−1) in summer, and DCM concentrations are from three to 10 times higher. The diatom Rhizosolenia eriensis was a dominant species in the epilimnion in spring and at the DCM for much of the year, but was rare in the epilimnion during summer, and consequently was not affected by the nutrient additions. Cyclotella spp. were also abundant in spring, were a prominent component of the DCM, and increased in abundance during nutrient additions. The cyanobacterium Synechococcus was the dominant member of the autotrophic picoplankton community and during the nutrient additions densities reached 300 000∙mL−1 (a 10-fold increase). Bacterioplankton numbers also increased during nutrient additions, at times exceeding 3.0 × 106∙mL−1. The DCM was formed and maintained by sinking cells, by occasional active photosynthesis at the DCM, and by an increase in chlorophyll/cell.
23
Schatzberg, S., N. Olby, S. Steingold, et al. "A polymerase chain reaction screening strategy for the promoter of the canine dystrophin gene." American Journal of Veterinary Research 60, no. 9 (1999): 1040–46. http://dx.doi.org/10.2460/ajvr.1999.60.09.1040.
Full textAbstract:
Abstract Objective To develop a polymerase chain reaction (PCR) strategy to screen the dystrophin promoter(s) in dogs with cardiac and skeletal myopathies. Animals 9 Doberman Pinschers, 1 Dalmation, and 1 Saint Bernard with dilated cardiomyopathy (DCM); 1 Irish Terrier with muscular dystrophy; and 2 dystrophin-deficient German Shorthaired Pointers (GSHP). Procedure For each of the 3 unique exons associated with the muscle (M), Purkinje (P), and cortical (C) promoters of the dystrophin gene, each first exon, and the M promoter plus its first exon, were amplified, cloned, and sequenced. The M dystrophin transcript was amplified by reverse transcriptase PCR from skeletal and cardiac muscle RNA of 1 Doberman Pinscher and from skeletal muscle RNA of 1 GSHP. Results The M, P and C first exons were amplified from all dogs except the 2 GSHP, which had a deletion encompassing the entire M, P, and C dystrophin promoter region. The M transcript could not be amplified from muscles of the GSHP, but was amplified from skeletal and cardiac muscle of the Doberman Pinscher. Sequencing of the product representing the M promoter and its first exon revealed no differences between clinically normal dogs and the Doberman Pinscher with DCM. Conclusions and Clinical Relevance We have ruled out a major rearrangement of the dystrophin promoter region as the universal cause of DCM in Doberman Pinschers or of Irish Terrier myopathy. Use of the strategy identified a large deletion of this region in muscle from the GSHP. (Am J Vet Res 1999;60:1040-1046)
24
Countway, Peter D., and David A. Caron. "Abundance and Distribution of Ostreococcus sp. in the San Pedro Channel, California, as Revealed by Quantitative PCR." Applied and Environmental Microbiology 72, no. 4 (2006): 2496–506. http://dx.doi.org/10.1128/aem.72.4.2496-2506.2006.
Full textAbstract:
ABSTRACT Ostreococcus is a genus of widely distributed marine phytoplankton which are picoplanktonic in size (<2 μm) and capable of rapid growth. Although Ostreococcus has been detected around the world, little quantitative information exists on its contribution to planktonic communities. We designed and implemented a genus-specific TaqMan-based quantitative PCR (qPCR) assay to investigate the dynamics and ecology of Ostreococcus at the USC Microbial Observatory (eastern North Pacific). Samples were collected from 5 m and the deep chlorophyll maximum (DCM) between September 2000 and August 2002. Ostreococcus abundance at 5 m was generally <5.0 × 103 cells ml−1, with a maximum of 8.2 × 104 cells ml−1. Ostreococcus abundance was typically higher at the DCM, with a maximum of 3.2 × 105 cells ml−1. The vertical distribution of Ostreococcus was examined in March 2005 and compared to the distribution of phototrophic picoeukaryotes (PPE) measured by flow cytometry. The largest contribution to PPE abundance by Ostreococcus was ∼70% and occurred at 30 m, near the DCM. Despite its relatively low abundance, the depth-integrated standing stock of Ostreococcus in March 2005 was ∼30 mg C m−2. Our work provides a new technique for quantifying the abundance of Ostreococcus and demonstrates the seasonal dynamics of this genus and its contribution to picoeukaryote biomass at our coastal sampling station.
25
Micolonghi, Caterina, Marco Fabiani, Erika Pagannone, et al. "A Novel Nonsense Pathogenic TTN Variant Identified in a Patient with Severe Dilated Cardiomyopathy." Current Issues in Molecular Biology 45, no. 3 (2023): 2422–30. http://dx.doi.org/10.3390/cimb45030157.
Full textAbstract:
Both genetic and environmental factors contribute to the development of dilated cardiomyopathy. Among the genes involved, TTN mutations, including truncated variants, explain 25% of DCM cases. We performed genetic counseling and analysis on a 57-year-old woman diagnosed with severe DCM and presenting relevant acquired risk factors for DCM (hypertension, diabetes, smoking habit, and/or previous alcohol and cocaine abuse) and with a family history of both DCM and sudden cardiac death. The left ventricular systolic function, as assessed by standard echocardiography, was 20%. The genetic analysis performed using TruSight Cardio panel, including 174 genes related to cardiac genetic diseases, revealed a novel nonsense TTN variant (TTN:c.103591A > T, p.Lys34531*), falling within the M-band region of the titin protein. This region is known for its important role in maintaining the structure of the sarcomere and in promoting sarcomerogenesis. The identified variant was classified as likely pathogenic based on ACMG criteria. The current results support the need of genetic analysis in the presence of a family history, even when relevant acquired risk factors for DCM may have contributed to the severity of the disease.
26
Hadi, Hasriana, Nur Salsabila Ahmad Roslan, and Normaiza Zamri. "GC-MS Analysis and In Vitro Antioxidant Activity of Crude Extracts and Different Fractions of Moringa Oleifera Pods." Materials Science Forum 1025 (March 2021): 247–51. http://dx.doi.org/10.4028/www.scientific.net/msf.1025.247.
Full textAbstract:
Moringa oleifera (M. oleifera) has been known as a medicinal plant. The objectives of this study is to identify the chemical compositions of M. oleifera pods extracts and to evaluate its total phenolic content (TPC) and antioxidant activity. The methodology of this study began with the collection of the pod's sample, drying and grinding the pods into powdered form. M. oleifera pods extracts were prepared by using methanol (MeOH), hexane, dichloromethane (DCM), and ethyl acetate (EtOAc) solvent which yielded respective residues. All extracts were subjected to Gas Chromatography-Mass Spectrometry (GC-MS) to identify its chemical compositions. Major compound found in hexane, DCM, EtOAc, and MeOH extracts were nonanoic acid (30.94 %), diisooctyl phthalate (89.45 %), benzoic acid, 4-hydroxy- (37.57 %) and octanoic acid (19.19 %), respectively. The TPC quantification was done via Folin-Ciocalteu method showed that EtOAc extract has the highest phenols content with 500.05 mg GAE/g. Generally, all extract contain moderate phenolic content. M. oleifera pods extracts were screened for the antioxidant activity via 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical. Hexane, DCM and EtOAc extracts exhibited good free radical scavenging activity with IC50 of 65.79 μg/mL, 74.93 μg/mL and 82.83 μg/mL, respectively. MeOH showed the lowest free radical scavenging activity with IC50 529.6 μg/mL. However, antioxidant activity of all extracts was low compared to standard, ascorbic acid (AA) with IC50 of 19.57 μg/mL. The presence of various bioactive constituents in the M. oleifera pods extracts might contributed to the antioxidant activity of the plant.
27
Sánchez-España, Javier, Carmen Falagán, Diana Ayala, and Katrin Wendt-Potthoff. "Adaptation of Coccomyxa sp. to Extremely Low Light Conditions Causes Deep Chlorophyll and Oxygen Maxima in Acidic Pit Lakes." Microorganisms 8, no. 8 (2020): 1218. http://dx.doi.org/10.3390/microorganisms8081218.
Full textAbstract:
Deep chlorophyll maxima (DCM) and metalimnetic oxygen maxima (MOM) are outstanding biogeochemical features of acidic pit lakes (APL). However, knowledge of the eukaryotic phototrophs responsible for their formation is limited. We aimed at linking the dynamics of phototrophic communities inhabiting meromictic APL in Spain with the formation of these characteristic layers. Firstly, the dynamics of DCM and MOM and their relation to physico-chemical parameters (photosynthetically active radiation (PAR), pH, dissolved ferric iron concentration, temperature), pigments and nutrient distribution is described; secondly, the phototrophic community composition is studied through a combination of microscopy, biomolecular and “omics” tools. Phototrophic communities of the studied APL show a low diversity dominated by green microalgae, specifically Coccomyxa sp., which have been successfully adapted to the chemically harsh conditions. DCM and MOM are usually non-coincident. DCM correspond to layers where phototrophs have higher chlorophyll content per cell to cope with extremely low PAR (<1 µmol m−2 s−1), but where photosynthetic oxygen production is limited. MOM correspond to shallower waters with more light, higher phytoplankton biomass and intense photosynthetic activity, which affects both oxygen concentration and water temperature. The main drivers of DCM formation in these APL are likely the need for nutrient uptake and photo-acclimation.
28
Kobayashi, Hiroshi, Koji Otani, Takuya Nikaido, et al. "Development of a Novel Diagnostic Support Tool for Degenerative Cervical Myelopathy Combining 10-s Grip and Release Test and Grip Strength: A Pilot Study." Diagnostics 12, no. 9 (2022): 2108. http://dx.doi.org/10.3390/diagnostics12092108.
Full textAbstract:
Early diagnosis of degenerative cervical myelopathy (DCM) is desirable, as delayed treatment can cause irreversible spinal cord injury and subsequent activity of daily living (ADL) impairment. We attempted to develop a straightforward and accurate diagnostic tool for DCM by combining the grip and release test (GRT) and grip strength. As a pilot study, we measured the GRT and grip strength of patients with DCM (n = 247) and a control group (n = 721). Receiver operating characteristic analysis was performed using the lower left and right. The Youden index was used to set cutoff values by sex and age group. The diagnostic performance of each test varied by sex and age, and a diagnostic support tool was created to determine any abnormal results in a test. The calculated M/F cutoff values for GRT were as follows: 40–59 years, 21/18; 60–69 years, 17/17; 70–79 years, 15/15; and 80–89 years, 11/12. The calculated M/F cutoff values for grip strength 32/20, 29/13, 21/15, and 19/10. When either GRT or grip strength was judged as positive, the overall sensitivity was 88.2%, specificity was 78.1%, positive likelihood ratio was 4.03, and the negative likelihood ratio was 0.15. This novel diagnostic support tool was superior to using GRT and grip strength alone in the early DCM diagnosis. Future research to obtain age- and sex-specific data is necessary to validate and further improve the tool.
29
Marañón, Emilio, France Van Wambeke, Julia Uitz, et al. "Deep maxima of phytoplankton biomass, primary production and bacterial production in the Mediterranean Sea." Biogeosciences 18, no. 5 (2021): 1749–67. http://dx.doi.org/10.5194/bg-18-1749-2021.
Full textAbstract:
Abstract. The deep chlorophyll maximum (DCM) is a ubiquitous feature of phytoplankton vertical distribution in stratified waters that is relevant to our understanding of the mechanisms that underpin the variability in photoautotroph ecophysiology across environmental gradients and has implications for remote sensing of aquatic productivity. During the PEACETIME (Process studies at the air-sea interface after dust deposition in the Mediterranean Sea) cruise, carried out from 10 May to 11 June 2017, we obtained 23 concurrent vertical profiles of phytoplankton chlorophyll a, carbon biomass and primary production, as well as heterotrophic prokaryotic production, in the western and central Mediterranean basins. Our main aims were to quantify the relative role of photoacclimation and enhanced growth as underlying mechanisms of the DCM and to assess the trophic coupling between phytoplankton and heterotrophic prokaryotic production. We found that the DCM coincided with a maximum in both the biomass and primary production but not in the growth rate of phytoplankton, which averaged 0.3 d−1 and was relatively constant across the euphotic layer. Photoacclimation explained most of the increased chlorophyll a at the DCM, as the ratio of carbon to chlorophyll a (C:Chl a) decreased from ca. 90–100 (g:g) at the surface to 20–30 at the base of the euphotic layer, while phytoplankton carbon biomass increased from ca. 6 mg C m−3 at the surface to 10–15 mg C m−3 at the DCM. As a result of photoacclimation, there was an uncoupling between chlorophyll a-specific and carbon-specific productivity across the euphotic layer. The ratio of fucoxanthin to total chlorophyll a increased markedly with depth, suggesting an increased contribution of diatoms at the DCM. The increased biomass and carbon fixation at the base of the euphotic zone was associated with enhanced rates of heterotrophic prokaryotic activity, which also showed a surface peak linked with warmer temperatures. Considering the phytoplankton biomass and turnover rates measured at the DCM, nutrient diffusive fluxes across the nutricline were able to supply only a minor fraction of the photoautotroph nitrogen and phosphorus requirements. Thus the deep maxima in biomass and primary production were not fuelled by new nutrients but likely resulted from cell sinking from the upper layers in combination with the high photosynthetic efficiency of a diatom-rich, low-light acclimated community largely sustained by regenerated nutrients. Further studies with increased temporal and spatial resolution will be required to ascertain if the peaks of deep primary production associated with the DCM persist across the western and central Mediterranean Sea throughout the stratification season.
30
Wei, Zhongshan, Wenyan Deng, Zhengyong Feng, Tao Wang, and Xinxiang Huang. "An MPC-DCM Control Method for a Forward-Bending Biped Robot Based on Force and Moment Control." Electronics 13, no. 22 (2024): 4374. http://dx.doi.org/10.3390/electronics13224374.
Full textAbstract:
For a forward-bending biped robot with 10 degrees of freedom on its legs, a new control framework of MPC-DCM based on force and moment is proposed in this paper. Specifically, the Diverging Component of Motion (DCM) is a stability criterion for biped robots based on linear inverted pendulum, and Model Predictive Control (MPC) is an optimization solution strategy using rolling optimization. In this paper, DCM theory is applied to the state transition matrix of the system, combined with simplified rigid body dynamics, the mathematical description of the biped robot system is established, the classical MPC method is used to optimize the control input, and DCM constraints are added to the constraints of MPC, making the real-time DCM approximate to a straight line in the walking single gait. At the same time, the linear angle and friction cone constraints are considered to enhance the stability of the robot during walking. In this paper, MATLAB/Simulink is used to simulate the robot. Under the control of this algorithm, the robot can reach a walking speed of 0.75 m/s and has a certain anti-disturbance ability and ground adaptability. In this paper, the Model-H16 robot is used to deploy the physical algorithm, and the linear walking and obstacle walking of the physical robot are realized.
31
RYU, Hyun-Seok, Jun-Seok LEE, and Chung-Gu KANG. "BER Analysis of Dual-Carrier Modulation (DCM) over Nakagami-m Fading Channel." IEICE Transactions on Communications E94-B, no. 7 (2011): 2123–26. http://dx.doi.org/10.1587/transcom.e94.b.2123.
Full text
32
Sajeendran, Athira, Sindhu K. Rajan, Madhavan Unny, Ambily V.R, and Soumya Ramankutty. "Modified Simpson’s method of disc in the diagnosis of dilated cardiomyopathy in dogs." Journal of Veterinary and animal sciences 55, no. 4 (2024): 734–38. https://doi.org/10.51966/jvas.2024.55.4.734-738.
Full textAbstract:
Dilated cardiomyopathy, the second most common canine acquired heart disease, is one of the leading cause morbidity and mortality in middle to old aged large breed dogs. The cases presented with signs suggestive of cardiac diseases were screened for DCM with the aid of standard B mode and one dimentional M-mode echocardiography. Totally eight confirmed cases of DCM were selected for the present study and subjected to modified Simpson’s method of discs for LV volume measurement and biplanar EF. All the parameters under study were repeated in six healthy control dogs also. The data was analysed statistically by paired t-test. The results showed a statistically significant increase in LV EDVI and ESVI and significant reduction in EF BP, compared to control. This study demonstrated that the twodimensional modified Simpson’s method of discs as a superior alternative to M-mode measurements for assessing left ventricular (LV) volume. Since, M-mode relied on a one-dimensional approach based on LV geometry, which might lead to inaccuracies, especially in cases of LV dyssynchrony in diseased heart. In contrast, the Simpson’s method accurately captures the complex three-dimensional shape of the LV by summing elliptical discs, providing a more precise assessment of LV volume. This improved accuracy is essential for diagnosing the chamber enlargement and volume and managing conditions like DCM, making the 2D modified Simpson’s method the preferred choice in veterinary cardiology. Keywords: Dilated cardiomyopathy, Simpson’s method of discs, Simpson’s rule, echocardiography, end-diastolic volume, end systolic volume
33
Ahmad, Imran, Samina Afzal та Muhammad Atif Shahzad. "α-Amylase Inhibitory, Immunomodulatory, Phytotoxic, Antifungal Activities and Phytochemical Screening of Medicago Denticulata". International Journal of Current Research and Review 14, № 06 (2022): 09–16. http://dx.doi.org/10.31782/ijcrr.2022.14602.
Full textAbstract:
Introduction: The plants are an alternative source for the management of a number of human disorders because of diverse metabolites. Aims: Current study targets to probe underexplored therapeutic potentials of Medicago denticulata (M. denticulata) through phytochemical and biological assays. Methods: The dried whole plant (aerial and root parts) was extracted in succession with dichloromethane (DCM) and methanol by simple maceration process and designated with codes MDWD and MDWM respectively. Results: The phytochemical investigation uncovered the occurrence of saponins, terpenoids, tannins, phenols and flavonoids in the extracts. MDWD fraction unveiled the highest total phenolic contents 54.47 μg GAE / mg dry weight (DW), The total reducing potential 58.125 μg AAE / mg DW and total antioxidant capacity 81.71 µg AAE / mg, while MDWM fraction revealed maximum flavonoids content 16.72 μg QE / mg DW. The phytotoxicity of methanol and DCM extracts exhibited 73% and 63% growth regulation respectively at concentration of 1000 µg/mL. Extracts revealed antidiabetic activity through α-amylase inhibition. The maximum inhibition i.e. 116.91% was detected at the concentration of 1000 mg / mL by DCM extract. Conclusion: Dichloromethane and methanolic extracts of M. denticulata are well thought-out as the potential source of antioxidants and could provide immunomodulatory, antifungal, phytotoxic and a-amylase inhibition activities.
34
Liu, Shunyu, Xuanding Hei, Hong Wu, and Zhentao Wang. "Mitophagy Regulation by Kangxian Yixin Granule in a Mouse Model of Dilated Cardiomyopathy." Chinese medicine and natural products 03, no. 02 (2023): e67-e74. http://dx.doi.org/10.1055/s-0043-1770075.
Full textAbstract:
Abstract Objective Kangxian Yixin granule (KXYXG) has been found to be effective in the clinical treatment of dilated cardiomyopathy (DCM). We aim to explore the effect of KXYXG and the underlying mechanism in a mouse model of DCM. Methods Thirty specific pathogen-free (SPF) male cTnTR141W mice with DCM were randomly divided into the model group, KXYXG (20.4 g/kg/d) group and coenzyme Q10 (CoQ10) (1.5 mg/kg/d) group; 10 SPF male C57BL/6J mice were included to form the normal group. The mice in KXYXG group and CoQ10 group were administered by oral gavage for 8 weeks. M-echocardiography was used to evaluate the cardiac function in mice, and hematoxylin and eosin staining and transmission electron microscopy were performed to observe morphological characters. The colocalization and expression levels of mitophagy-related proteins were observed using immunofluorescence and western blot. Results Compared with the normal group, the model group showed ventricular remodeling, cardiac insufficiency, disordered arrangement of cardiomyocytes, as well as disordered mitochondria and irregular and diffuse swelling. Furthermore, the model group had lower mitophagy protein colocalization and autophagy flux. Furthermore, PINK1 and Parkin expression levels decreased in the mice with DCM (p < 0.05). KXYXG could decrease the left ventricular end-diastolic and end-systolic diameters and mitochondrial injury, rescue cardiac dysfunction and remodeling, and protect against myocardial ultrastructure changes in the mice with DCM. KXYXG also increased the colocalization levels of mitophagy-related proteins and PINK1 and Parkin expression levels compared with those in the model group (p < 0.05). Conclusion KXYXG can protect against heart injury by possibly activating the PINK1/Parkin pathway and mitophagy in mice with DCM.
35
Estrada Miyares, Marta, Mikel Latasa, Ana M. Cabello, et al. "Relationships between the deep chlorophyll maximum and hydrographic characteristics across the Atlantic, Indian and Pacific oceans." Scientia Marina 88, no. 4 (2024): e092. https://doi.org/10.3989/scimar.05519.092.
Full textAbstract:
The Malaspina-2010 circumnavigation expedition on board R/V Hesperides surveyed tropical and subtropical regions of the Atlantic, Indian and Pacific oceans between December 2010 and July 2011. This article examines the relationships between the distribution of chlorophyll a (Chl a), major inorganic nutrients and other hydrographic variables. A deep chlorophyll maximum (DCM) was found at most stations between 60 and 150 m depth; it occurred close to the level of 1% surface photosynthetically active radiation and was associated with the nitracline. There was a negative relationship between total Chl a at surface and the DCM depth, and between Chl a concentration at the DCM and DCM depth. In terms of Chl a concentration, picophytoplankton was the dominant size class at all sampled light intensities (surface, 20% of surface PAR and PAR at DCM), oceans and geoclimatic zones, except at some stations influenced by upwellings or divergences. Within the Chl a concentration ranges found in this study, the proportion of picophytoplankton increased with total Chl a, in contrast with some previous findings. Vertically integrated Chl a was positively correlated with surface Chl a, with similar slopes for the whole data set and for the different oceans and zones. In turn, surface Chl a and sea surface temperature showed a negative correlation for the Indian Ocean and the subtropical zone, a positive correlation for the Atlantic, and non-significant relationships for the remaining oceans and zones.
36
Ajayi, O. S., S. M. Arowosegbe, and I. J. Olawuni. "GC-MS characterization and bioactivity studies of aerial part of <i>Hilleria latifolia</i> (lam) extract and fractions: Antioxidant and antibacterial potentials." Ife Journal of Science 26, no. 3 (2025): 569–84. https://doi.org/10.4314/ijs.v26i3.2.
Full textAbstract:
This study sets out on identifying active compounds within Hilleria latifolia (Lam) extracts and fractions, with a specific emphasis on their potential antibacterial and antioxidant activities. GC-MS analysis was employed to characterize the chemical constituents in the n-hexane (n-Hex) and dichloromethane (DCM) fractions. The nHex and DCM fractions of the aerial part of Hilleria latifolia (Lam) revealed the presence of 45 compounds (27 in n-Hex and 18 in DCM), many of which are known for their antioxidant, anticancer, anti-inflammatory, and antibacterial properties. Antioxidant activity was evaluated through iron-reducing power (FRAP), nitric oxide (NO) inhibition, metal chelating ability (MC), total antioxidant capacity (TAC) and 2,2-diphenyl-1- picrylhydrazyl (DPPH) assays. The EtOAc fraction showed the best activities in DPPH (IC 0.70±0.026 50 mg/mL), FRAP (478.503±8.607 mg AAE/g), MCA (0.199±0.085 mg/mL) and TAC (227.37±60.949 mg AAE/g). The sensitivity testing of the crude methanolic extract and fractions were carried out using the agarwell diffusion method against three gram-positive (Bacillus stearothermophillus, Staphylococcus aureus, and Micrococcus luteus) and five gram-negative (Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli, Proteus vulgaris, and Serratia marcescens) bacterial strains. The crude methanol extract and aqueous fraction did not show activity towards all the bacterial strains. However, the n-Hex fraction exhibited moderate antibacterial activity particularly against K. pneumoniae (12 mm), M. luteus (9 mm), P. aeruginosa (12 mm), B. stearothermophillus (10 mm), and S. aureus (12 mm), the DCM fraction also showed effective antibacterial activity against K. pneumoniae (16 mm), M. luteus (12 mm), P. vulgaris (11 mm), B. stearothermophillus (12 mm), E. coli (12 mm) and S. aureus (11 mm). The ethyl acetate (EtOAc) fractions have shown considerable antibacterial activity against K. pneumoniae (12 mm), M. luteus (12 mm), P. vulgaris (11 mm), B. stearothermophillus (12 mm) and S. aureus (8 mm). The present findings demonstrate the antioxidant and antibacterial properties of Hilleria latofolia fractions, underscoring the need for further research to confirm their medicinal potential and explore its pharmaceutical applications.
37
Kozioł, Ewelina, Simon Vlad Luca, Hale Gamze Ağalar, et al. "Rutamarin: Efficient Liquid–Liquid Chromatographic Isolation from Ruta graveolens L. and Evaluation of Its In Vitro and In Silico MAO-B Inhibitory Activity." Molecules 25, no. 11 (2020): 2678. http://dx.doi.org/10.3390/molecules25112678.
Full textAbstract:
Naturally occurring coumarins are a group of compounds with many documented central nervous system (CNS) activities. However, dihydrofuranocoumarins have been infrequently investigated for their bioactivities at CNS level. Within the frame of this study, an efficient liquid–liquid chromatography method was developed to rapidly isolate rutamarin from Ruta graveolens L. (Rutaceae) dichloromethane extract (DCM). The crude DCM (9.78 mg/mL) and rutamarin (6.17 M) were found to be effective inhibitors of human monoamine oxidase B (hMAO-B) with inhibition percentages of 89.98% and 95.26%, respectively. The inhibitory activity against human monoamine oxidase A (hMAO-A) for the DCM extract was almost the same (88.22%). However, for rutamarin, it significantly dropped to 25.15%. To examine the molecular interaction of rutamarin with hMAO- B, an in silico evaluation was implemented. A docking study was performed for the two enantiomers (R)-rutamarin and (S)-rutamarin. The (S)-rutamarin was found to bind stronger to the hMAO-B binging cavity.
38
Thushara, Venugopal, Puthenveettil Narayana Menon Vinayachandran, Adrian J. Matthews, Benjamin G. M. Webber, and Bastien Y. Queste. "Vertical distribution of chlorophyll in dynamically distinct regions of the southern Bay of Bengal." Biogeosciences 16, no. 7 (2019): 1447–68. http://dx.doi.org/10.5194/bg-16-1447-2019.
Full textAbstract:
Abstract. The Bay of Bengal (BoB) generally exhibits surface oligotrophy due to nutrient limitation induced by strong salinity stratification. Nevertheless, there are hotspots of high chlorophyll in the BoB where the monsoonal forcings are strong enough to break the stratification; one such region is the southern BoB, east of Sri Lanka. A recent field programme conducted during the summer monsoon of 2016, as a part of the Bay of Bengal Boundary Layer Experiment (BoBBLE), provides a unique high-resolution dataset of the vertical distribution of chlorophyll in the southern BoB using ocean gliders along with shipboard conductivity–temperature–depth (CTD) measurements. Observations were carried out for a duration of 12–20 days, covering the dynamically active regions of the Sri Lanka Dome (SLD) and the Southwest Monsoon Current (SMC). Mixing and upwelling induced by the monsoonal wind forcing enhanced surface chlorophyll concentrations (0.3–0.7 mg m−3). Prominent deep chlorophyll maxima (DCM; 0.3–1.2 mg m−3) existed at intermediate depths (20–50 m), signifying the contribution of subsurface productivity to the biological carbon cycling in the BoB. The shape of chlorophyll profiles varied in different dynamical regimes; upwelling was associated with sharp and intense DCM, whereas mixing resulted in a diffuse and weaker DCM. Within the SLD, open-ocean Ekman suction favoured a substantial increase in chlorophyll. Farther east, where the thermocline was deeper, enhanced surface chlorophyll was associated with intermittent mixing events. Remote forcing by the westward propagating Rossby waves influenced the upper-ocean dynamics and chlorophyll distribution in the southern BoB. Stabilizing surface freshening events and barrier-layer formation often inhibited the generation of surface chlorophyll. The pathway of the SMC intrusion was marked by a distinct band of chlorophyll, indicating the advective effect of biologically rich Arabian Sea waters. The region of the monsoon current exhibited the strongest DCM as well as the highest column-integrated chlorophyll. Observations suggest that the persistence of DCM in the southern BoB is promoted by surface oligotrophy and shallow mixed layers. Results from a coupled physical–ecosystem model substantiate the dominant role of mixed layer processes associated with the monsoon in controlling the nutrient distribution and biological productivity in the southern BoB. The present study provides new insights into the vertical distribution of chlorophyll in the BoB, emphasizing the need for extensive in situ sampling and ecosystem model-based efforts for a better understanding of the biophysical interactions and the potential climatic feedbacks.
39
Suryana, Angela, Andi Hairil Alimuddin, and Rudiyansyah Rudiyansyah. "Dukunolide D from the Root of Lansium domesticum Corr. cv Kokosan." Chimica et Natura Acta 13, no. 1 (2025): 9–14. https://doi.org/10.24198/cna.v13.n1.54511.
Full textAbstract:
Lansium domesticum has three varieties and one of the varieties is kokosan. These plants contain limonoids as the main constituents. Phytochemical investigation of L. domesticum cv kokosan has identified onoceranoids-type triterpenoids and tetranortriterpenoids from the seeds, fruit peels, and bark except for the root. This research described dukunolide D (1) that has been obtained from the methanol extract of the root of kokosan. Methanol root extract was fractioned by n-hexane and dichloromethane (DCM). All fractions including the crude extract were screened for phytochemical test. The DCM fraction was chromatographed in order to obtain compound 1. DART-HRMS of compound 1 showed a positive ion peak at m/z 469.1861 [M+H]+ (calculated 469.1862 corresponding for C26H29O8). The structure of 1 was fully determined by 1D (1H-NMR, 13C-NMR, and DEPT-135) and 2D NMR (COSY, HSQC, HMBC, and NOESY), and by comparison with data from literature.
40
Castanheiro, Letícia F., Antonio M. G. Tommaselli, Heikki Hyyti, and Antero Kukko. "Experimental assessment of IMU data processing techniques for a backpack mobile laser scanning system." International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XLVIII-3-2024 (November 7, 2024): 57–62. http://dx.doi.org/10.5194/isprs-archives-xlviii-3-2024-57-2024.
Full textAbstract:
Abstract. Positioning techniques are fundamental in many automation tasks with several applications. In GNSS-denied environments like in dense forests, other alternatives are required, such as inertial and visual navigation. However, Inertial Measurement Units (IMUs) data, mainly those from microelectromechanical-system (MEMS), are noisy, which affects the orientation estimation. MEMS IMUs have been employed in mobile laser scanning systems due to their compact design and low-cost solutions for short-term navigation. In this paper, we have compared three IMU processing techniques freely available: MAH (Mahony et al., 2009), MAD (Madgwick et al., 2011) and DCM (Hyyti and Visala, 2015). These techniques implemented different approaches to estimate the attitude. They were experimentally assessed with data from a backpack mobile laser scanning system, which is composed of an OS0-128 Ouster LiDAR equipped with an internal IMU. We have used data from a 5-second trajectory segment aiming to evaluate the attitude and position estimation for a local path. The results showed that the DCM algorithm maintained a consistent velocity for 5 seconds, achieving a positional error of 1.4 m, 0.06 m, and 1.05 m along the X-, Y- and Z-axis, respectively. In contrast, MAD and MAH showed a position error over 20 m, 7 m and 3 m along the X-, Y- and Z-axis, respectively, which was affected by the velocity drift.
41
Paliwal, Monica, Kenneth A. Weber, Andrew C. Smith, et al. "Fatty infiltration in cervical flexors and extensors in patients with degenerative cervical myelopathy using a multi-muscle segmentation model." PLOS ONE 16, no. 6 (2021): e0253863. http://dx.doi.org/10.1371/journal.pone.0253863.
Full textAbstract:
Background In patients with degenerative cervical myelopathy (DCM) that have spinal cord compression and sensorimotor deficits, surgical decompression is often performed. However, there is heterogeneity in clinical presentation and post-surgical functional recovery. Objectives Primary: a) to assess differences in muscle fat infiltration (MFI) in patients with DCM versus controls, b) to assess association between MFI and clinical disability. Secondary: to assess association between MFI pre-surgery and post-surgical functional recovery. Study design Cross-sectional case control study. Methods Eighteen patients with DCM (58.6 ± 14.2 years, 10 M/8F) and 25 controls (52.6 ± 11.8 years, 13M/12 F) underwent 3D Dixon fat-water imaging. A convolutional neural network (CNN) was used to segment cervical muscles (MFSS- multifidus and semispinalis cervicis, LC- longus capitis/colli) and quantify MFI. Modified Japanese Orthopedic Association (mJOA) and Nurick were collected. Results Patients with DCM had significantly higher MFI in MFSS (20.63 ± 5.43 vs 17.04 ± 5.24, p = 0.043) and LC (18.74 ± 6.7 vs 13.66 ± 4.91, p = 0.021) than controls. Patients with increased MFI in LC and MFSS had higher disability (LC: Nurick (Spearman’s ρ = 0.436, p = 0.003) and mJOA (ρ = -0.399, p = 0.008)). Increased MFI in LC pre-surgery was associated with post-surgical improvement in Nurick (ρ = -0.664, p = 0.026) and mJOA (ρ = -0.603, p = 0.049). Conclusion In DCM, increased muscle adiposity is significantly associated with sensorimotor deficits, clinical disability, and functional recovery after surgery. Accurate and time efficient evaluation of fat infiltration in cervical muscles may be conducted through implementation of CNN models.
42
Kotby, Alyaa A., Manal M. Abdel Aziz, Waleed M. El Guindy, and Amira N. Moneer. "Can Serum Tenascin-C Be Used as a Marker of Inflammation in Patients with Dilated Cardiomyopathy?" International Journal of Pediatrics 2013 (2013): 1–6. http://dx.doi.org/10.1155/2013/608563.
Full textAbstract:
Background. Tenascin-C (TN-C) is an extracellular matrix glycoprotein that appears at sites of inflammation in cardiac pathologies.Aim of the Work. To evaluate the role of TN-C as a marker for active inflammation in children with dilated cardiomyopathy (DCM).Subjects and Methods. 24 consecutive patients with primary nonfamilial DCM aged 6–72 months (mean45.19±11.03) were divided into group I, twelve patients with acute onset DCM (<6 months duration), and group II, twelve patients with chronic DCM (>6 months duration), and compared to 20 healthy age- and sex-matched controls. Investigations included estimation of serum TN-C and echocardiographic evaluation using M-mode and 2D speckle tracking echocardiography (STE).Results. Serum TN-C showed a higher significant statistical elevation among patients than controls (P<0.001) and in group I than group II (P<0.001). EF was significantly decreased, and LVEDD and EDV increased in patients than controls and in GI than GII. STE showed a statistically significant difference in global peak strain longitudinal (GPSL) average in patients than controls (P<0.05) and between GI and GII (P<0.001). STE wall motion scoring showed normokinesia (33.5%), hypokinesia (8.33%), and akinesia (50%) in GI and hypokinesia (100%) in GII. There was a statistically significant positive correlation between serum TN-C and GPSL average.Conclusions. Increased serum TN-C can be used as a marker of inflammation in DCM and is associated with the severity of heart failure and LV dysfunction as detected by STE.
43
Das, Anju Kumari, Maya Das, Nabin Karki, Dipak Kumar Gupta, and Amar Prasad Yadav. "Investigation of Organic Fraction of Mahonia Nepalensis for Effective Corrosion Prevention of Mild Steel." Patan Pragya 13, no. 2 (2024): 1–21. https://doi.org/10.3126/pragya.v13i2.78778.
Full textAbstract:
Plant extracts are a conceivably better substitute for corrosion prevention of metallic materials that are acceptable to the environment. This study investigates about the application of the organic fraction of Mahonia nepalensis (MN) bark extract for the corrosion protection of mild steel (MS) in 1 M H2SO4. The separation of the organic layer from MN bark extracts were subjected to column chromatography using the dichloromethane (DCM)-methanol as solvent for the separation of alkaloids. The identification and quantification of compounds of the DCM-methanol fraction was performed by liquid column mass spectrometry (LC-MS). Fourier transform infrared (FTIR) and ultraviolet-visible spectroscopy (UV-Vis) were used to characterize the DCM-methanol fraction of the MN extract. Potentiodynamic polarization (PDP) and electrochemical impedance spectroscopy (EIS) were used to investigate the corrosion inhibition of MS using the DCM-Methanol fractions in 1M H2SO4. The DCM-Methanol fraction containing 1.2 ppm berberine exhibited an inhibitory efficiency (IE) of 84.35%, suggesting that it is a viable and reasonable choice for preventing MS corrosion. The potentiodynamic polarization reflected a decrease in the hydrogen reduction, as indicated by the suppression of the cathodic current without altering the reaction process. According to open circuit potential and polarization curves, it showed mixed inhibitory behavior. EIS analysis also found a decrease in double-layer capacitance and an increase in charge transfer resistance. EIS and energy dispersive X-ray spectroscopy (EDX) in a scanning electron microscope (SEM) confirmed inhibitor molecules have adhered to the MS surface to form a protective coating
44
Arachchige, Sirimal Premakumara Galbada, Walimuni Prabhashini Kaushalya Mendis Abeysekera, and Wanigasekera Daya Ratnasooriya. "Antiamylase, Anticholinesterases, Antiglycation, and Glycation Reversing Potential of Bark and Leaf of Ceylon Cinnamon (Cinnamomum zeylanicum Blume) In Vitro." Evidence-Based Complementary and Alternative Medicine 2017 (2017): 1–13. http://dx.doi.org/10.1155/2017/5076029.
Full textAbstract:
Ethanol (95%) and dichloromethane : methanol (DCM : M, 1 : 1 v/v) bark extracts (BEs) and leaf extracts (LEs) of authenticated Ceylon cinnamon (CC) were studied for antiamylase, antiglucosidase, anticholinesterases, and antiglycation and glycation reversing potential in bovine serum albumin- (BSA-) glucose and BSA-methylglyoxal models in vitro. Further, total proanthocyanidins (TP) were quantified. Results showed significant differences (p<0.05) between bark and leaf extracts for the studied biological activities (except antiglucosidase) and TP. BEs showed significantly high (p<0.05) activities for antiamylase (IC50: 214±2–215±10 μg/mL), antibutyrylcholinesterase (IC50: 26.62±1.66–36.09±0.83 μg/mL), and glycation reversing in BSA-glucose model (EC50: 94.33±1.81–107.16±3.95 μg/mL) compared to LEs. In contrast, glycation reversing in BSA-methylglyoxal (EC50: ethanol: 122.15±6.01 μg/mL) and antiglycation in both BSA-glucose (IC50: ethanol: 15.22±0.47 μg/mL) and BSA-methylglyoxal models (IC50: DCM : M: 278.29±8.55 μg/mL) were significantly high (p<0.05) in leaf. Compared to the reference drugs used some of the biological activities were significantly (p<0.05) high (BEs: BChE inhibition and ethanol leaf: BSA-glucose mediated antiglycation), some were comparable (BEs: BSA-glucose mediated antiglycation), and some were moderate (BEs and LEs: antiamylase, AChE inhibition, and BSA-MGO mediated antiglycation; DCM : M leaf: BSA-glucose mediated antiglycation). TP were significantly high (p<0.05) in BEs compared to LEs (BEs and LEs: 1097.90±73.01–1381.53±45.93 and 309.52±2.81–434.24±14.12 mg cyanidin equivalents/g extract, resp.). In conclusion, both bark and leaf of CC possess antidiabetic properties and thus may be useful in managing diabetes and its complications.
45
Jackson, Leland J., John G. Stockner, and Paul J. Harrison. "Contribution of Rhizosolenia eriensis and Cyclotella spp. to the Deep Chlorophyll Maximum of Sproat Lake, British Columbia, Canada." Canadian Journal of Fisheries and Aquatic Sciences 47, no. 1 (1990): 128–35. http://dx.doi.org/10.1139/f90-013.
Full textAbstract:
Experimental fertilization of Sproat Lake with nitrogen and phosphorus greatly increased the abundance of two centric diatoms: Cyclotella spp. and Rhizosolenia eriensis. A decrease in sinking rates to neutral buoyancy at 17.5–22.5 m, an area of high nutrients and low light, coupled with sedimentation estimates of 106–107 celis∙m−2∙d−1, provide strong evidence that diatoms contribute to the formation of a seasonal deep chlorophyll maximum (DCM). The position of the Sproat Lake DCM, occurring at or just above the 1% light depth, appears to be largely determined by the light regime. R. eriensis bloomed and sank out of the mixed layer early in the spring before lake fertilization began. Immediately after fertilization, concentrations of nitrate and phosphate were elevated for 1 h only in the top 1 m of the water column. Most R. eriensis cells were well below 1 m and benefited little from the nutrient addition because of temporal and spatial separation. Cyclotella spp. occurred in the upper epilimnion and bloomed later in the year and consequently benefited (by large density increases) from fertilization. It is important to consider the temporal and spatial distribution of phytoplankton in determining which species will increase in abundance as a result of areal fertilization.
46
Li, Jing-Ya, Chun-Chun Zhao, Jian-Fei Peng, et al. "The Protective Effect of Sheng Mai Yin on Diabetic Cardiomyopathy via NLRP3/Caspase-1 Pathway." Evidence-Based Complementary and Alternative Medicine 2022 (December 1, 2022): 1–12. http://dx.doi.org/10.1155/2022/1234434.
Full textAbstract:
Sheng Mai Yin (SMY) has therapeutic effects on myocardial infarction (MI), heart failure (HF), diabetic cardiomyopathy (DCM), and myocarditis. To study whether SMY can relieve pyroptosis and play a protective role in diabetic cardiomyopathy, a molecular docking technique was used to predict the possible mechanism of SMY against DCM. Then, a DCM rat model was induced by intraperitoneal injection of streptozotocin (STZ), divided into 5 groups: the DM group (model), SMY-L group (2.7 mL/kg SMY), SMY-M group (5.4 mL/kg SMY), SMY-H group (10.8 mL/kg SMY), and Met group (120 mg/kg metformin). Rats in the CTL group (control) and DM group were given normal saline. After 8 weeks, the levels of blood glucose, lipids, and myocardial enzymes were detected according to the kit instructions. Cardiac function was detected by echocardiography. HE and Masson were used to observing the pathological changes, collagen deposition, and collagen volume fraction (CVF). The apoptosis rate of cardiomyocytes was determined by Tunel. The IL-1β level was determined by ELISA and RT-PCR. The expressions of NLRP3, caspase-1, and GSDMD were measured using RT-PCR and Western blotting. The docking results suggested that SMY may act on NLRP3 and its downstream signal pathway. The in vivo results showed that SMY could reduce blood glucose and lipid levels, improve heart function, improve histopathological changes and myocardial enzymes, and alleviate cardiomyocyte apoptosis and myocardial fibrosis. SMY inhibited the mRNA and protein expressions of NLRP3, ASC, Caspase-1, and GSDMD and IL-1β production. SMY can reduce DCM by regulating the NLRP3/caspase-1 signaling pathway, providing a new research direction for the treatment of DCM.
47
Wojciechowska, Celina, Jan Wodniecki, Romuald Wojnicz, et al. "Neopterin and Beta-2 Microglobulin Relations to Immunity and Inflammatory Status in Nonischemic Dilated Cardiomyopathy Patients." Mediators of Inflammation 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/585067.
Full textAbstract:
Background. The aim of the study was to assess the relationships among serum neopterin (NPT),β2-microglobulin (β2-M) levels, clinical status, and endomyocardial biopsy results of dilated cardiomyopathy patients (DCM).Methods. Serum NPT andβ-2 M were determined in 172 nonischaemic DCM patients who underwent right ventricular endomyocardial biopsy and 30 healthy subjects (ELISA test). The cryostat biopsy specimens were assessed using histology, immunohistology, and immunochemistry methods (HLA ABC, HLA DR expression, CD3 + lymphocytes, and macrophages counts).Results. The strong increase of HLA ABC or HLA DR expression was detected in 27.2% patients—group A—being low in 72.8% patients—group B. Neopterin level was increased in patients in group A compared to healthy controls 8.11 (4.50–12.57) versus 4.99 (2.66–8.28) nmol/L (P<0.05).β-2 microglobulin level was higher in DCM groups A (2.60 (1.71–3.58)) and B (2.52 (1.51–3.72)) than in the control group 1.75 (1.28–1.96) mg/L,P<0.001. Neopterin correlated positively with the number of macrophages in biopsy specimens (P<0.05) acute phase proteins: C-reactive proteins (P<0.05); fibrinogen (P<0.01); and NYHA functional class (P<0.05) and negatively with left ventricular ejection fraction (P<0.05).Conclusions. Neopterin but notβ-2 microglobulin concentration reflected immune response in biopsy specimens. Neopterin correlated with acute phase proteins and stage of heart failure and may indicate a general immune and inflammatory activation in heart failure.
48
Velmurugan, Kolanjiappan. "Reduction of amine and biological antioxidants on NOx emissions powered by mango seed biodiesel." Revista Facultad de Ingeniería –redin-, no. 84 (September 25, 2017): 46–54. https://doi.org/10.17533/udea.redin.n84a06.
Full textAbstract:
This study scrutinizes the influence of amine and biological antioxidants on reduction of NOx emissions in a diesel engine fueled with B100 (100 vol.% mango seed methyl ester) and B20 (20 vol.% mango seed methyl ester and 80 vol.% diesel fuel blend). Three amine antioxidants, p-phenylenediamine (PPD), Ethylendiamine (EDA) and N,N’-diphenyl- 1,4-phenylenediamine (DPPD) and three biological antioxidants, dichloromethane (DCM), alpha tocopherol acetate (α-T) and L-ascorbic acid (L-asc.acid) are tested in a kirloskar-make single cylinder four-stroke water cooled diesel engine of 5.9 KW rated power. There are five concentrations used in the antioxidant mixture of biodiesel blends. i.e., 0.005%-m, 0.010%-m, 0.025%-m, 0.05%-m and 0.1%-m. Where, %-m is the molar concentration employed in the antioxidant mixture. Results show that consequential reduction in NOx could be acquired by the accession of antioxidant additive DPPD with the 0.025% concentration from B20 fuel by 15.4% and B100 fuel by 39%. The DPPD additive increased the CO emissions over 7.42% for B100 fuel and 6.44% for B20 fuel. The biological antioxidant DCM exhibits 0.235 g/kWhr for B100 fuel and 0.297 g/kWhr for B20 fuel. Smoke emission is found to have increased with the addition of antioxidants. Slight increase in brake thermal efficiency (0.91%) is accomplished with the addition of antioxidants at full load. The experimental results are compared with analysis of variance and the result is merely the same as to that of experimentation.
49
Mirzaev, Sayibdjan, Majid Yusupov, Barna Rakhmankulova, Feruza Umarova, and Gulnaz Abdikayimova. "Vertical vibrations of traction engine with viscoelastic suspension." E3S Web of Conferences 365 (2023): 01022. http://dx.doi.org/10.1051/e3sconf/202336501022.
Full textAbstract:
The tasks of a traction engine with suspension elements and additional devices for converting movement (DCM) are considered. The object of protection, the estimated dynamic state, is solid with mass M and moment of inertia J relative to the center of gravity. To account the suspension material's rheological properties, the Boltzmann-Volterra principle is used. Mathematical models of the problem under consideration are obtained, which are described by the systems of integro-differential equations. A solution method based on quadrature formulas is developed, and a computer program is compiled based on its basis, the results of which are reflected in the graphs. The influence of DCM and rheological properties of the suspension material on the shape of the vertical vibrations of the object is investigated.
50
Gong, Jinu, and Hoojin Lee. "Asymptotic BER Analysis of Dual-carrier Modulation (DCM) Scheme over Nakagami-m Fading Channel." Journal of the Institute of Electronics and Information Engineers 62, no. 1 (2025): 63–66. https://doi.org/10.5573/ieie.2025.62.1.63.
Full text