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Journal articles on the topic 'M. P. Möller Organ Company'

Author: Grafiati

Published: 29 July 2024

Last updated: 31 July 2025

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1

Takase, Y., H. Doi, T. Iwasaki, et al. "THU0285 ANALYSIS OF THE RELATIONSHIP BETWEEN ORGAN DAMAGE AND QUALITY OF LIFE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 369.2–370. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3027.

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Background:Systemic lupus erythematosus (SLE) is an autoimmune disease that can not only cause systemic symptoms, such as fever and arthritis, but can also damage important organs, such as those of the central nervous system and the kidneys. Prevention of irreversible organ damage is important for better prognosis [1]. Additionally, the importance of maintaining the quality of life (QOL) of patients has recently been emphasized. However, only a few studies have examined the relationship between irreversible organ damage and patient QOL.Objectives:To assess the relationship between organ damage

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Kawamura, Koji, Junya Kanda, Sachiko Seo, et al. "Difference in the Donor Selection Priority in Allogeneic Hematopoietic Stem Cell Transplantation According to Patient Age." Blood 134, Supplement_1 (2019): 46. http://dx.doi.org/10.1182/blood-2019-125032.

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Introduction: Selection of an appropriate donor is important for the success of allogeneic hematopoietic stem cell transplantation (allo-HCT). In general, an HLA-matched related donor (M-RD) and an HLA-matched unrelated donor (M-UD) are considered to be the first and second preferred donors in allo-HCT. On the other hand, the most suitable alternative donor remains unclear, when M-RD and M-UD are unavailable. In addition, the information on a suitable donor selection for elderly patients are limited. We hypothesized that the patient age might change the donor selection priority in allo-HCT, be

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Dispenzieri, Angela, Eftathios Kastritis, Ashutosh D. Wechalekar, et al. "Primary Results from the Phase 3 Tourmaline-AL1 Trial of Ixazomib-Dexamethasone Versus Physician's Choice of Therapy in Patients (Pts) with Relapsed/Refractory Primary Systemic AL Amyloidosis (RRAL)." Blood 134, Supplement_1 (2019): 139. http://dx.doi.org/10.1182/blood-2019-124409.

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Background Systemic AL amyloidosis is a clonal plasma cell disorder in which amyloid fibrils are deposited in tissues and organs, leading to multi-system organ dysfunction. The most frequently involved organs are the heart and kidney (individually or together), with advanced cardiac involvement conferring particularly poor outcomes. Achievement of hematologic response and improved organ function result in better outcomes. There are currently no approved treatments for AL amyloidosis; multiple myeloma (MM) treatment strategies are used for these pts. Active, tolerable treatment options specific

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Hamilton, Betty K., Lisa A. Rybicki, Taylor Lucas, et al. "Randomized Trial of Tacrolimus and Methotrexate Versus Tacrolimus, Reduced Dose Methotrexate, and Mycophenolate Mofetil for Prevention of Graft-Versus-Host Disease after Myeloablative Related and Unrelated Donor Allogeneic Hematopoietic Cell Transplantation." Blood 138, Supplement 1 (2021): 99. http://dx.doi.org/10.1182/blood-2021-149686.

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Abstract Background: Graft-versus-host disease (GVHD) remains a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). The combination of tacrolimus (Tac) and methotrexate (MTX) is a standard regimen for GVHD prophylaxis; however, it is associated with several toxicities and patients are often not able to complete the full MTX regimen. The combination of Tac, reduced dose ("mini")-MTX, and mycophenolate mofetil (MMF) has been investigated with a well-tolerated toxicity profile and low incidence of GVHD, although comparison with standard dose MTX has n

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Paolino, S., E. Gotelli, A. Casabella, et al. "SAT0337 EVALUATION OF BODY COMPOSITION AND BONE STATUS ACCORDING TO MICROVASCULAR INVOLVEMENT IN SYSTEMIC SCLEROSIS PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1114.3–1114. http://dx.doi.org/10.1136/annrheumdis-2020-eular.5693.

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Background:Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease, characterized by autoimmune inflammatory microvascular damage with progressive loss of capillaries, fibrosis and ischemia of skin and internal organs. (1) Nailfold videocapillaroscopy (NVC) is a safe toll for early diagnosis of SSc, it identify morphological changes of vessel that are predictive for clinical disease progression and organ involvement.(2) About clinical complication the loss of bone mass and body composition abnormalities, particularly muscle mass and strength loss (sarcopenia), are recognized

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Zamir, Itai, Tamir Shragai, Svetlana Trestman, et al. "Multiple Myeloma Oligosecretory Relapse, a Non-Negligible Phenomenon. Frequency, Clinical Characteristics and Outcomes in a Single Center." Blood 138, Supplement 1 (2021): 3772. http://dx.doi.org/10.1182/blood-2021-151255.

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Abstract Introduction: Multiple myeloma (MM) is malignancy of plasma cells, which secrete monoclonal antibodies that are detectable in the patient's (pt) serum and/or urine. Infrequently, MM may present as an oligosecretory disease, where monoclonal protein (M-protein) and involved free light chain (iFLC) are either not detected (=non-secretory) or are both below the threshold for measurable disease (=oligosecretory) as defined by International Myeloma Working Group (IMWG). The incidence of non-secretory MM at presentation has been estimated at 1-2% [Chawla, Eur J Haematol 2015], yet data rega

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Watson, Crystal, Hemanth Gadikota, Arie Barlev, and Rachel Beckerman. "An Evidence Review of the Long-Term Consequences Associated with Components of the CHOP Chemotherapy Regimen in Transplant Recipients." Blood 138, Supplement 1 (2021): 4586. http://dx.doi.org/10.1182/blood-2021-147242.

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Abstract Introduction: Epstein-Barr virus-driven post-transplant lymphoproliferative disease (EBV + PTLD) can be an aggressive, often deadly disease without any approved treatments. Current available treatments for EBV + PTLD may include cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP). However, the long-term consequences of CHOP are poorly understood in immunocompromised transplant patients with cancer who may have different outcomes than immunocompetent cancer patients. This study reviewed and described the evidence for the long-term consequences associated with components o

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Comenzo, Raymond, Giovanni Palladini, Efstathios Kastritis, et al. "Subcutaneous Daratumumab with Bortezomib, Cyclophosphamide, and Dexamethasone in Patients with Newly Diagnosed Light Chain (AL) Amyloidosis: 18-Month Analysis of the Phase 3 ANDROMEDA Study." Blood 138, Supplement 1 (2021): 159. http://dx.doi.org/10.1182/blood-2021-146820.

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Abstract Introduction: Light chain (AL) amyloidosis is a plasma cell disease characterized by the deposition of insoluble amyloid fibrils into organs leading to organ dysfunction and death. The analysis at 6 and 12 months of the ANDROMEDA study (NCT03201965) showed that the addition of subcutaneous (SC) daratumumab to the standard of care combination of bortezomib, cyclophosphamide, and dexamethasone (VCd) was superior to VCd alone, with higher rates of hematologic complete response (CR) and an acceptable safety profile. Based on these findings daratumumab with VCd (D-VCd) was approved for new

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Bouchra, Ait El Aouad, Fadli Anas, Aderdour Tarik, Talha Abdelhak, Benkirane Rachid, and Benahia Hamid. "Investigating salt tolerance in citrus rootstocks under greenhouse conditions using growth and biochemical indicators." Biolife 3, no. 4 (2022): 820–26. https://doi.org/10.5281/zenodo.7306481.

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  <strong>ABSTRACT</strong> Citrus is ranked among the most sensitive crops to salinity. This constrainst affects plant morpho-physiology and may lead to yield declines. To assess the effects of salinity on some physiological and biochemical traits, an in vivo screening test was performed under controled saline conditions using different citrus rootstocks i.e. citrumelo 57-98-502, Swingle citrumelo F9-22-55 (80-11), citrumelo 57-98-506, Swingle citrumelo 74-1, citrumelo Winter Haven B2, Carrizo citrange 28608, Troyer citrange C35B6A11, Troyer citrange B2 31655, citrumelo 4475 B2G3, citrum

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Daver, Naval, Sreyashi Basu, Guillermo Garcia-Manero, et al. "Azacitidine (AZA) with Nivolumab (Nivo), and AZA with Nivo + Ipilimumab (Ipi) in Relapsed/Refractory (R/R) Acute Myeloid Leukemia: Clinical and Immune Biomarkers of Response." Blood 136, Supplement 1 (2020): 43–45. http://dx.doi.org/10.1182/blood-2020-142824.

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Background: Blockade of PD-1/PD-L1 pathways enhances anti-leukemic responses in pre-clinical studies. PD1 inhibition alone had limited clinical activity in AML. CLTA4 inhibition demonstrated encouraging single-agent CR's in postASCT patients (pts), especially for extra-medullary (EMD) relapses (Davis M et al, NEJM 2016). AZA+Nivo up-regulated CTLA4 on bone marrow (BM) CD8 cells in both responders (R) and non-responders (NR) on treatment (Daver N, et al, Cancer Discovery 2019), suggesting a triplet of AZA+Nivo+Ipi may abrogate PD-1 mediated resistance. Methods: Pts were eligible for the AZA+Niv

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Kotb, Rami, Engin Gul, Nizar Abdel-Samad, Ibraheem Othman, Michel Pavic, and Donna E. Reece. "Pembrolizumab Added to First-Line Cyclophosphamide, Bortezomib and Dexamethasone in Newly Diagnosed Transplant Non-Eligible Myeloma Patients: A Phase 2A Open Label, Multi Centre Study." Blood 138, Supplement 1 (2021): 4768. http://dx.doi.org/10.1182/blood-2021-153897.

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Abstract Background: Despite recent improvements, myeloma is still incurable. There is need to add new therapeutic tools. The combination of the proteasome inhibitor (PI) Bortezomib, an alkylator (Cyclophosphamide or Melphalan) and Dexamethasone (Dex) /Prednisone is a widely used first-line therapy. Most patients achieve a rapid response within the first two cycles. The lack of a deep response to the bortezomib-based therapy predicts an inferior outcome, a poor response to newer PIs and limited therapeutic options. Different studies highlighted the role of the PD1/PDL1 pathway in myeloma immun

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Elsayed, AA, RM Ibrahim, and MM Shaaban. "Evaluation of role of chest sonography in assessment of patients presenting with shock to emergency department." Biolife 3, no. 4 (2022): 869–79. https://doi.org/10.5281/zenodo.7306754.

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<strong>ABSTRACT</strong> Assessment of hemodynamic status in a shock state remains a challenging issue in Emergency Medicine and Critical Care. As the use of invasive hemodynamic monitoring declines, bedside-focused ultrasound has become a valuable tool in the evaluation and management of patients in shock. No longer a means to simply evaluate organ anatomy, ultrasound has expanded to become a rapid and non-invasive method for the assessment of patient physiology. Clinicians caring for critical patients should strongly consider integrating ultrasound into their resuscitation pathways the use

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Hillmen, Peter, Alexandra Pitchford, Adrian Bloor, et al. "Ibrutinib Plus Rituximab Is Superior to FCR in Previously Untreated CLL: Results of the Phase III NCRI FLAIR Trial." Blood 138, Supplement 1 (2021): 642. http://dx.doi.org/10.1182/blood-2021-152319.

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Abstract Introduction: The most effective chemoimmunotherapy (CIT) in previously untreated CLL is the combination of fludarabine, cyclophosphamide and rituximab (FCR). Ibrutinib (I), the first irreversible inhibitor of Bruton's tyrosine kinase approved for CLL, has improved outcomes in numerous clinical trials compared to different CIT. Methods: FLAIR (ISRCTN01844152) is an ongoing, phase III, multicentre, randomised, controlled, open, parallel group trial for previously untreated CLL requiring therapy according to the IWCLL 2008 guidelines. Patients over 75 years or with &gt;20% 17p-delet

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Treon, Steven P., Christina K. Tripsas, Leukothea Ioakimidis, et al. "Prospective, Multicenter Study of the MTOR Inhibitor Everolimus (RAD001) As Primary Therapy in Waldenstrom's Macroglobulinemia." Blood 118, no. 21 (2011): 2951. http://dx.doi.org/10.1182/blood.v118.21.2951.2951.

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Abstract Abstract 2951 Introduction: Everolimus (RAD001) is an inhibitor of MTORC1, a component of the Akt-MTOR pathway which regulates growth and survival of lymphoplasmacytic cells in Waldenstrom's Macroglobulinemia (WM). Everolimus also exhibits activity in WM patients with relapsed/refractory disease (Ghobrial et al, JCO 2010; 28 :1408–14). We therefore initiated this multicenter, prospective study to delineate the efficacy and tolerability of Everolimus as primary therapy in WM. Patients and Methods: WM patients with symptomatic disease, adequate organ function, who were not previously tr

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Yilmaz, Musa, Hagop Kantarjian, Nicholas J. Short, et al. "Hypomethylating Agent (HMA) Therapy and Venetoclax (VEN) with FLT3 Inhibitor "Triplet" Therapy Is Highly Active in Older/Unfit Patients with FLT3 Mutated AML." Blood 138, Supplement 1 (2021): 798. http://dx.doi.org/10.1182/blood-2021-154143.

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Abstract Introduction Internal tandem duplication (ITD) and tyrosine kinase domain (TKD) mutations (m) in FLT3 occur in about 30% of the patients (pts) with newly diagnosed AML. FLT3m are associated with a higher risk of relapse and inferior overall survival (OS). Outcomes remain poor in older/unfit pts with FLT3m AML; with expected median OS of 8-12 months with combinations of low intensity chemotherapy (LIC) with FLT3 inhibitors (FLT3i) or with venetoclax (VEN) [Ohanian et al. AJH, 2018; Konopleva et. al. ASH, 2020). In this current study, our goal was to analyze outcomes in newly diagnosed

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Rohini, P. "Effect of the drug Diclofenac on the brain tissue of Channa punctatus." Biolife 8, no. 4 (2022): 1–4. https://doi.org/10.5281/zenodo.7275472.

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<strong>Abstract</strong> Pharmaceuticals are the biologically active compounds that are designed to exert specific action on the target molecules of human and veterinary animals. The erroneous use of these drugs has resulted in aquatic pollution. Diclofenac is a non-steroidal anti- inflammatory drug that has been usually detected in surface waters worldwide. There are investigations on the toxicity of this drug in aquatic flora and fauna. The acute toxic studies on the histological alterations in fish are very rare. The brain is an important organ which controls all functions of the body. The

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Bachanova, Veronika, Joseph E. Maakaron, Frank Cichocki, et al. "Gda-201, a Novel Metabolically Enhanced Allogeneic Natural Killer (NK) Cell Product Yields High Remission Rates in Patients with Relapsed/Refractory Non-Hodgkin Lymphoma (NHL): 2-Year Survival and Correlation with Cytokine IL7." Blood 138, Supplement 1 (2021): 3854. http://dx.doi.org/10.1182/blood-2021-149989.

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Abstract Background: The innate capacity of natural killer (NK) cells to kill tumor targets has been translated into cancer immunotherapy. GDA-201 represents a novel class of metabolically enhanced ex-vivo expanded allogeneic NK cells with acquired capacity for improved organ trafficking, augmented resistance against exhaustion and in vivo proliferation. We conducted a phase 1 study of GDA-201 in combination with rituximab (NCT03019666) in patients (pts) with relapsed or refractory (R/R) non-Hodgkin lymphoma (NHL) and report 2-year outcomes and cytokine biomarkers associated with survival. Met

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Bhandari, Sudhir, Ajit Singh Shaktawat, Bhoopendra Patel, et al. "The sequel to COVID-19: the antithesis to life." Journal of Ideas in Health 3, Special1 (2020): 205–12. http://dx.doi.org/10.47108/jidhealth.vol3.issspecial1.69.

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The pandemic of COVID-19 has afflicted every individual and has initiated a cascade of directly or indirectly involved events in precipitating mental health issues. The human species is a wanderer and hunter-gatherer by nature, and physical social distancing and nationwide lockdown have confined an individual to physical isolation. The present review article was conceived to address psychosocial and other issues and their aetiology related to the current pandemic of COVID-19. The elderly age group has most suffered the wrath of SARS-CoV-2, and social isolation as a preventive measure may furth

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Kim, Kunhwa, Hagop Kantarjian, Gautam Borthakur, et al. "A Phase II Study of CPX-351 Plus Venetoclax in Patients with Relapsed/Refractory (R/R) or Newly Diagnosed Acute Myeloid Leukemia (AML)." Blood 138, Supplement 1 (2021): 1275. http://dx.doi.org/10.1182/blood-2021-154148.

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Abstract Background : CPX-351 is a dual-drug liposomal encapsulation of cytarabine(araC) and daunorubicin at a 5:1 molar ratio that is approved for treatment of newly diagnosed therapy-related AML or AML-MRC. Compared to 7+3, CPX-351 was associated with higher response rates (47.7% vs 33.3%) and improved overall survival (OS) in these patients. In an earlier phase I study, CPX-351 produced a CR/CRi rate of 23% in patients with R/R AML. Based on the activity of venetoclax (VEN) with lower intensity therapy in newly diagnosed AML, we investigated safety and efficacy of VEN combined with CPX-351

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HARTLEY, MARYALICE, MACKENZIE J. PEARSON, FAROOQ SYED, KENNETH D. ROTH, TATSUYOSHI KONO та CARMELLA EVANS-MOLINA. "1832-P: SERCA2 Regulates the Lipidome and Insulin Secretion in Pancreatic β-Cells". Diabetes 74, Supplement_1 (2025). https://doi.org/10.2337/db25-1832-p.

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Introduction and Objective: The sarco-ER Ca2+ ATPase (SERCA2) pump maintains endoplasmic reticulum (ER) Ca2+ levels in the pancreatic β-cell. Previously, we demonstrated reduced SERCA2 expression in islets from human organ donors with type 2 diabetes (T2D) compared to islets from non-diabetic organ donors. Additionally, we have shown that heterozygous deletion of SERCA2 in mice (S2HET) leads to reduced whole body glucose tolerance and impaired islet glucose stimulated insulin secretion (GSIS) in response to diet-induced obesity. Because the ER is the major hub for lipid synthesis, we hypothesi

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Brouillette, Matthew A., Farid L. Khan, Santiago M. C. Lopez, et al. "P-2062. COVID-19 XBB.1.5-adapted Vaccine Uptake in Immunocompromised Individuals Using Tokenized State Vaccine Registries." Open Forum Infectious Diseases 12, Supplement_1 (2025). https://doi.org/10.1093/ofid/ofae631.2218.

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Abstract Background Immunocompromised individuals experience a disproportionate burden of COVID-19-associated hospitalization and death. COVID-19 vaccine uptake has declined over time. We evaluated XBB.1.5-adapted vaccine uptake, regardless of brand, during the 2023-2024 season among immunocompromised persons using data from two large state vaccine registries. Methods Individuals with continuous pharmacy and medical enrollment (≥6 months for children &lt; 18 years, ≥12 months for adults ≥18 years) in insurance plans contributing to HealthVerity and residency in either California or Louisia

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TESI, MARTA, MARA SULEIMAN, ROBERTO SEMERARO, et al. "1750-P: Rescuing Human Beta-Cell Dysfunction Induced by Proinflammatory Cytokines and Glucotoxicity." Diabetes 73, Supplement_1 (2024). http://dx.doi.org/10.2337/db24-1750-p.

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Introduction & Objective: Residual insulin secretion (IS) from surviving beta cells (BC) can be hampered by a stressful T1D islet microenvironment (e.g. cytokines - Cyt, increased glucose - G). We evaluated the effects of Cyt and Cyt+G on isolated human islet (HI) IS, assessed if BC dysfunction is reversible, and explored the associated molecular mechanisms. Methods: HI from five nondiabetic organ donors (age, 78±15 yrs; BMI, 24.4±3.8 kg/m2) were exposed to Cyt (50 U/ml IL-1β + 1000 U/ml IFN-γ) at 5.5 or 11.1 mM G for 24h, followed by 72h culture in normal medium (wash-out, WO). IS at 3.3

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Berry, Mark, Valentina Shvachko, Amanda Kong, Rohan Shah, Gina Brown, and Anand Chokkalingam. "P-1925. Incidence of long COVID symptoms during the year post admission among patients hospitalized for COVID-19." Open Forum Infectious Diseases 12, Supplement_1 (2025). https://doi.org/10.1093/ofid/ofae631.2085.

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Abstract Background The CDC defines long COVID as new, returning or ongoing health problems occurring at least 4 weeks after infection. However, it is uncertain how long different conditions may last after the infection. Our objective was to characterize incidence of common conditions that may be associated with long COVID across the first year after admission among patients hospitalized for COVID-19.Table 1.Patient DemographicsIQR, interquartile rangea Immunocompromised condition during the past 12 months (symptomatic HIV infection, haematologic and solid malignancy, organ transplant, rheumat

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FERRULLI, ANNA, STEFANO MASSARINI, CONCETTA MACRÌ, et al. "1616-P: Effects of Hazelnuts Consumption Combined with Physical Activity on Lipid Metabolism and Correlations with Marrow Adiposity Homeostasis." Diabetes 72, Supplement_1 (2023). http://dx.doi.org/10.2337/db23-1616-p.

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Consumption of hazelnuts has been associated with reduced cardiovascular risk and improved metabolic outcomes. Furthermore, the Bone Marrow Fat (BMF) might contribute to skeletal as well as systemic metabolism, modulating insulin sensitivity and, consequently, cardiovascular risk. Previously, we demonstrated a beneficial effect of hazelnuts and cocoa integration on vascular reactivity and metabolic profile in healthy individuals. Aim of this randomized controlled interventional study with 3 parallel groups was to investigate the effects of a daily supplementation with 30 g of hazelnuts, with o

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RAISUL ABEDIN, MUHAMMAD, WILSON FREIJE, MALLORY A. OSWALT, et al. "303-OR: Notch Signaling Inhibitor ADPO-002 Promotes Browning in Human Adipose Tissue Explants." Diabetes 73, Supplement_1 (2024). http://dx.doi.org/10.2337/db24-303-or.

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Introduction: Transformation of white adipocytes into beige adipocytes, known as adipocyte browning, holds great promise for development of new therapeutics. Our previous studies have demonstrated nanoparticle-based delivery of dibenzazepine (ADPO-002), a γ-secretase inhibitor, induces browning of white adipose tissue in obese mice and in pigs. The current study aims to investigate the browning efficacy of ADPO-002 in human adipose tissue organ culture. Methods: Abdominal subcutaneous and omental adipose tissue samples were collected from 24 subjects undergoing bariatric surgery (BMI 47.5±3.2

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Soled, Derek, and Cray Noah. "Leveraging Machine Perfusion to Ameliorate Geographic Disparities in Organ Allocation." Voices in Bioethics 7 (May 9, 2021). http://dx.doi.org/10.52214/vib.v7i.8219.

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Photo by Robina Weermeijer on Unsplash INTRODUCTION Geographic inequities in access to donor lungs have persisted since the first successful lung transplant in 1983.[1] With unanswered questions regarding organ preservation and transport in the early days of transplantation, the United Network of Organ Sharing (UNOS) understandably incorporated geography in the allocation algorithm. Today, geography is still the most influential criterion in the lung allocation algorithm.[2] As a result, patients in urban centers often receive transplants before patients in less-resourced rural areas. Ex vivo

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OKUMURA, MIKI, YUMIE TAKESHITA, YUKA KAIKOI, HISANORI GOTO, YUJIRO NAKANO, and TOSHINARI TAKAMURA. "1643-P: Eight-Year Trajectories of Oral Glucose Tolerance Tests and Liver Enzymes in Nonobese Japanese Physical Examination Participants." Diabetes 74, Supplement_1 (2025). https://doi.org/10.2337/db25-1643-p.

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Introduction and Objective: To evaluate the impacts of insulin secretion and organ-specific insulin resistance on the development of metabolic dysfunction-associated steatotic liver disease (MASLD), we longitudinally examined oral glucose tolerance tests and liver enzymes in Japanese participants undergoing physical examination for 8 years. Methods: A 75g oral glucose tolerance test was evaluated in 105 participants (58 males, average age 52.5 years, BMI 22.9 kg/m2, and HbA1c 5.6%) at baseline and 8-year follow-up. We calculated the initial insulin secretory capacity (Insulinogenic Index, II),

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Clancy, Cornelius J., Oliver A. Cornely, Christine M. Slover, et al. "P-1475. Real-World Effectiveness and Safety of Cefiderocol in the Treatment of Patients with Serious Gram-negative Bacterial Infections: Results of the PROVE Chart Review Study." Open Forum Infectious Diseases 12, Supplement_1 (2025). https://doi.org/10.1093/ofid/ofae631.1645.

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Abstract Background The ongoing PROVE retrospective chart review study aims to assess real-world outcomes of cefiderocol treatment in patients with serious Gram-negative bacterial infections. Methods This is an interim analysis of hospitalized patients with suspected or confirmed Gram-negative bacterial infections in Europe and the USA treated with cefiderocol for the first time for ≥72 hours (Nov 2020–Feb 2024). A total of 1000 patients are planned. Baseline demographics, clinical characteristics, cefiderocol use, clinical cure, clinical response at end of treatment (EOT), in-hospital all-cau

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Paolino, S., E. Gotelli, A. Casabella, et al. "SAT0337 EVALUATION OF BODY COMPOSITION AND BONE STATUS ACCORDING TO MICROVASCULAR INVOLVEMENT IN SYSTEMIC SCLEROSIS PATIENTS." January 25, 2021. https://doi.org/10.1136/annrheumdis-2020-eular.5693.

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Background:Systemic sclerosis (SSc) is a complex autoimmune connective tissue disease, characterized by autoimmune inflammatory microvascular damage with progressive loss of capillaries, fibrosis and ischemia of skin and internal organs. (1) Nailfold videocapillaroscopy (NVC) is a safe toll for early diagnosis of SSc, it identify morphological changes of vessel that are predictive for clinical disease progression and organ involvement.(2) About clinical complication the loss of bone mass and body composition abnormalities, particularly muscle mass and strength loss (sarcopenia), are recognized

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Fendereski, K., J. Horns, H. Dehghanbanadaki, et al. "(303) The Predictive Role of Baseline Hormone Profile Evaluation for the Likelihood of Having a Child in Infertile Men." Journal of Sexual Medicine 21, Supplement_1 (2024). http://dx.doi.org/10.1093/jsxmed/qdae001.288.

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Abstract Introduction Sex hormone profile evaluation is commonly used in male infertility assessment to identify potential hormonal imbalances and underlying issues that can impact sperm production, sperm quality, or reproductive organ function. Objective To evaluate the likelihood of having a child in subfertile and infertile men within five years based on their serum hormone levels on their initial encounter for infertility evaluation/treatment. Methods We identified a retrospective cohort from the Subfertility, Health, and Assisted Reproduction (SHARE) study (compiled 1996-2017) linked with

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B2041171009, HARNOTO. "PENGARUH PRAKTEK MSDM TERHADAP ORGANIZATIONAL CITIZENSHIP BEHAVIOUR (OCB) MELALUI KEPUASAN KERJA SEBAGAI MEDIATOR (STUDI PADA PEGAWAI UPT PPD PROVINSI KALIMANTAN BARAT)." Equator Journal of Management and Entrepreneurship (EJME) 7, no. 4 (2019). http://dx.doi.org/10.26418/ejme.v7i4.34535.

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Pentingnya membangun OCB tidak lepas dari komitmen karyawan dalam organisasi. Komitmen karyawan akan mendorong terciptanya OCB dan tanpa adanya kontrol yang baik dalam pemberian kompensasi yang sesuai dengan hasil kerja tentunya memperlambat kerja pegawai. Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh kompensasi dan komitmen organisasi terhadap kepuasan kerja dan OCB. Jumlah responden dalam penelitian ini berjumlah 86 orang. Pengumpulan data diperoleh dengan kuesioner menggunakan skala likert. Metode analisis data menggunakan Path Analysis. Hasil penelitian diperoleh bahwa k

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Bowers, Olivia, and Mifrah Hayath. "Cultural Relativity and Acceptance of Embryonic Stem Cell Research." Voices in Bioethics 10 (May 16, 2024). http://dx.doi.org/10.52214/vib.v10i.12685.

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Photo ID 158378414 © Eduard Muzhevskyi | Dreamstime.com ABSTRACT There is a debate about the ethical implications of using human embryos in stem cell research, which can be influenced by cultural, moral, and social values. This paper argues for an adaptable framework to accommodate diverse cultural and religious perspectives. By using an adaptive ethics model, research protections can reflect various populations and foster growth in stem cell research possibilities. INTRODUCTION Stem cell research combines biology, medicine, and technology, promising to alter health care and the understanding

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sprotocols. "Analysis of carotenoid compounds in aphids by Raman imaging and mass spectrometry." January 6, 2015. https://doi.org/10.5281/zenodo.13783.

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Authors: Pierre Brat, Jean Christophe Valmalette, Christian Mertz, George de Sousa, Aviv Dombrovsky, Maria Capovilla & Alain Robichon ### Abstract Carotenoids are compounds synthesized in plants, bacteria and fungi, closely associated to the chlorophyll to perform photosynthesis. A spectacular evolutionary achievement allowed the aphid to produce carotenoids obviously by lateral transfer of genes from fungi. We have recently documented that these molecules are involved in photo conditioning of metabolism such ATP synthesis in this insect model. The carotenoid synthesis in aphid was directl

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Coull, Kim. "Secret Fatalities and Liminalities: Translating the Pre-Verbal Trauma and Cellular Memory of Late Discovery Adoptee Illegitimacy." M/C Journal 17, no. 5 (2014). http://dx.doi.org/10.5204/mcj.892.

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I was born illegitimate. Born on an existential precipice. My unwed mother was 36 years old when she relinquished me. I was the fourth baby she was required to give away. After I emerged blood stained and blue tinged – abject, liminal – not only did the nurses refuse me my mother’s touch, I also lost the sound of her voice. Her smell. Her heart beat. Her taste. Her gaze. The silence was multi-sensory. When they told her I was dead, I also lost, within her memory and imagination, my life. I was adopted soon after but not told for over four decades. It was too shameful for even me to know. Impri

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