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Journal articles on the topic 'M. tuberculosis - Rifampicin'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

Danlami, Mohammed Bashar, Basiru Aliyu, and Grace Samuel. "INCIDENCE OF RIFAMPICIN-RESISTANCE PRESUMPTIVE M. TUBERCULOSIS CASES AMONG OUTPATIENTS IN KEBBI STATE, NIGERIA." African Journal of Infectious Diseases 15, no. 1 (2020): 47–52. http://dx.doi.org/10.21010/ajid.v15i1.6.

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Background: The present study determined the incidence of rifampicin resistance M. tuberculosis among outpatients at the General Hospital Yauri, Kebbi State, Nigeria. Materials and Methods: The study is a cross-sectional study conducted from February 2018 to October 2019. Sociodemographic data were collected from hospital registration books. Rifampicin resistance M. tuberculosis was detected using GeneXpert Model GX-IV following manufacturers' instruction. Descriptive statistics and logistic regression were computed using SPSS version 20. The results were presented as odds ratios with associat

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de la Iglesia, Agustina I., Emma J. Stella, and Héctor R. Morbidoni. "Comparison of the Performances of Two In-House Rapid Methods for Antitubercular Drug Susceptibility Testing." Antimicrobial Agents and Chemotherapy 53, no. 2 (2008): 808–10. http://dx.doi.org/10.1128/aac.00960-08.

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ABSTRACT Resistance to rifampin (rifampicin), isoniazid, and streptomycin of 69 Mycobacterium tuberculosis isolates was analyzed by an in-house method based on mycobacteriophage D29 and a colorimetric micromethod. Both methods showed sensitivity and specificity values ranging from 93% to 100%. These simple methods offer an option for drug resistance assessment of M. tuberculosis.

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АХМЕТОВА, А. Ж., Ж. М. АБИЛОВА, Г. Н. ЖАРЫЛҚАСЫН, А. Р. АКИЛЬЖАНОВА та У. А. КОЖАМКУЛОВ. "ҚАЗАҚСТАНДА ТАРАЛҒАН РИФАМПИЦИН-ТӨЗІМДІ M. TUBERCULOSIS КЛИНИКАЛЫҚ ИЗОЛЯТТАРЫНЫҢ ГЕНЕТИКАЛЫҚ СИПАТТАМАСЫ". Vestnik, № 1(64) (14 квітня 2023): 53–65. http://dx.doi.org/10.53065/j5985-7576-8270-u.

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Лекарственно-устойчивый туберкулез остается актуальной проблемой в здравоохранении Казахстана. Казахстан одна из стран в мире с высоким количеством мультирезистентного туберкулеза, характеризующегося устойчивостью к основным антибиотикам первого ряда – рифампицину и изониазиду. Цель данной работы: определить биологическое разнообразие и охарактеризовать мутации в rpoB гене рифампицин-устойчивых клинических изолятов M. tuberculosis из Казахстана. В данной работе от больных с легочным туберкулезом было собрано 115 клинических изолятов M. tuberculosis, устойчивых к противотуберкулезному препарату

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Petrova, L. V., E. V. Sevastyanova, E. E. Larionova, and T. G. Smirnova. "GENOTYPIC AND PHENOTYPIC COMPARISON OF DRUG RESISTANCE PROFILES OF M. tuberculosis ISOLATES." Вестник ЦНИИТ 7, no. 4 (2023): 23–28. http://dx.doi.org/10.57014/2587-6678-2023-7-4-23-28.

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We conducted a comparative analysis of drug resistance of M. tuberculosis isolates to first-line TB drugs. The diagnostic samples and cultures of M. tuberculosis from TB patients were tested in the Mari El Republic. It was established that the divergence between genotypic and phenotypic isoniazid resistance did not exceed 4%, and rifampicin resistance – 3.9%. In most cases there was lack of mutations associated with resistance to isoniazid or rifampicin in the presence of phenotypic resistance. However, the divergence between results obtained by genotypic and different phenotypic methods was n

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Gautam, Praveen B., Ashwini Mishra, and Santosh Kumar. "Prevalence of rifampicin resistant mycobacterium tuberculosis and associated factors among presumptive tuberculosis patients in eastern Uttar Pradesh: a cross sectional study." International Journal Of Community Medicine And Public Health 5, no. 6 (2018): 2271. http://dx.doi.org/10.18203/2394-6040.ijcmph20182039.

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Background: Drug resistant tuberculosis threatens global TB control and is a major public health problem in several countries and India has the highest tuberculosis in the world. The rifampicin resistance is a good predictor of multidrug resistant tuberculosis. The aim of this study was to determine the prevalence of rifampicin resistance M. tuberculosis and associated factor among presumptive tuberculosis patients in eastern Uttar Pradesh.Methods: A cross-sectional study was conducted from October 2016 to September 2017. Detection of M. tuberculosis and resistance to rifampicin was performed

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Sanzhakov, M. A., O. M. Ipatova, T. I. Torkhovskaya, et al. "Increase of antituberculosis efficiency of rifampicin embedded into phospholipid nanoparticles with sodium oleate." Biomeditsinskaya Khimiya 64, no. 6 (2018): 505–10. http://dx.doi.org/10.18097/pbmc20186406505.

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The formulation of the antituberculosis drug rifampicin embedded into 20-30 nm nanoparticles from soy phosphatidylcholine and sodium oleate, is characterized by greater bioavailability as compared with free drug substance. In this study higher antituberculosis activity of this formulation was shown. Rifampicin in nanoparticles demonstrated more effective inhibition of M. tuberculosis H37Rv growth: minimal inhibiting concentration (MIC) was twice smaller than for free rifampicin. Administration of this preparation to mice with tuberculosis induced by M. tuberculosis Erdman revealed that after 6

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Notopuro, P. B., J. Nugraha, and H. Notopuro. "DETEKSI MOLEKUL MUTASI GEN rpoB MYCOBACTERIUM TUBERCULO SIS PADA DAHAK DENGAN POL YME RASE CHAIN REACTION DAN SINGLE STRAND CONFORMATION POLYMORPHISM." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 16, no. 2 (2018): 81. http://dx.doi.org/10.24293/ijcpml.v16i2.973.

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Tuberculosis is a chronic infectious disease which is found in the developing as well as the developed country. This disease is oneof the community health problems which become the priority programs in the national as well as international health. In the lasttwo decades, they can be found in the emergency tuberculosis problems that is related with the Multi Drug Resistance (MDR) Strain.The detection of rifampicin resistance in M. tuberculosis infection can help clinical laboratory to find the MDR strain. Related to thisproblem the proportional culture method is still the gold standard for rifa

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N. Djide, Nana Juniarti, M. Natsir Djide, Muhammad Nur Amir, and Sartini Sartini. "Aktivitas Antibakteri Ekstrak Kelopak Bunga Rosella Terenkapsulasi Maltodekstrin dan Sinergitasnya dengan Isoniazida dan Rifampisin Terhadap Mycobacterium tuberculosis H37rv." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) 5, no. 2 (2019): 117. http://dx.doi.org/10.22487/j24428744.0.v0.i0.12946.

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First-line drugs (Isoniazid and Rifampicin) for the treatment of tuberculosis are known to have experienced resistance to Mycobacterium tuberculosis. The aim of this study was to determine the minimum inhibitory concentration (MIC) of maltodextrin encapsulated rosella calyx extract and its ability to provide a synergistic effect with Isoniazid (INH) and Rifampicin (RIF) on M. tuberculosis R37rv. Rosella calyxs were macerated using 50% ethanol and encapsulated using maltodextrin. Antibacterial activity was carried out by determining MIC value using Microscopic Observation and Direct Susceptibil

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N. Djide, Nana Juniarti, M. Natsir Djide, Muhammad Nur Amir, and Sartini Sartini. "Aktivitas Antibakteri Ekstrak Kelopak Bunga Rosella Terenkapsulasi Maltodekstrin dan Sinergitasnya dengan Isoniazida dan Rifampisin Terhadap Mycobacterium tuberculosis H37rv." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 5, no. 2 (2019): 117–23. http://dx.doi.org/10.22487/j24428744.2019.v5.i2.12946.

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First-line drugs (Isoniazid and Rifampicin) for the treatment of tuberculosis are known to have experienced resistance to Mycobacterium tuberculosis. The aim of this study was to determine the minimum inhibitory concentration (MIC) of maltodextrin encapsulated rosella calyx extract and its ability to provide a synergistic effect with Isoniazid (INH) and Rifampicin (RIF) on M. tuberculosis R37rv. Rosella calyxs were macerated using 50% ethanol and encapsulated using maltodextrin. Antibacterial activity was carried out by determining MIC value using Microscopic Observation and Direct Susceptibil

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Mohiuddin, Md, and J. Ashraful Haq. "First Line Anti-Tubercular Drug Resistance Pattern of Mycobacterium Tuberculosis Isolated From Specialized Hospitals of Dhaka City." Ibrahim Medical College Journal 8, no. 2 (2016): 41–46. http://dx.doi.org/10.3329/imcj.v8i2.26677.

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The present study was undertaken to determine the drug resistance pattern of M. tuberculosis isolated from 225 pulmonary and 45 extrapulmonary tuberculosis cases. The samples were cultured on Lowenstein Jensen (L-J) media for isolation of M. tuberculosis. Drug resistance to first line anti tubercular drugsnamely isoniazid (INH), rifampicin (RIF), Ethambutol (ETH) and streptomycin (SM) were determined by indirect proportion method. The overall drug resistance of M. tuberculosis was 53.6% to any of the first line anti tubercular drugs. Rate of multi drug resistant tuberculosis (MDR-TB) among the

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Kashyap, Bineeta, Nisha Goyal, Puneeta Hyanki, NP Singh, and Ashwani Khanna. "Cartridge-based nucleic acid amplification test: a novel rapid diagnostic tool to study the burden of tuberculosis from a tertiary care hospital." Tropical Doctor 49, no. 4 (2019): 274–81. http://dx.doi.org/10.1177/0049475519859958.

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Despite efforts to limit the morbidity and mortality from tuberculosis (TB), it continues to be an important cause of death. There is an urgent need for a diagnostic test that accurately and quickly diagnoses TB, especially if it is also a near-point-of-care test. The GeneXpert polymerase chain reaction test (known in India as CBNAAT [cartridge-based nucleic acid amplification test] and is capable of diagnosing TB and rifampicin resistance within 2 h) is a promising tool. The duration of our study was two years and was carried out in the DOTS centre of a tertiary care hospital in India. A tota

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Zahoor, Danish, Shameem Wani, and Zaffer Nowshad Wani. "Evaluation of cepheid GeneXpert MTB/RIF assay for Mycobacterium tuberculosis detection and rifampicin resistance in clinical specimen." International Journal of Research in Medical Sciences 7, no. 6 (2019): 2121. http://dx.doi.org/10.18203/2320-6012.ijrms20192484.

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Background: Timely diagnosis and treatment of tuberculosis is important to treat the disease and to reduce transmission. The WHO recommends using GeneXpert MTB in developing, high-burden countries. A study was conducted to evaluate the performance of Xpert assay for the detection of M. tuberculosis and rifampicin resistance in clinical specimen.Methods: About 615 consecutive samples were simultaneously subjected to culture and phenotypic drug susceptibility test for M. tuberculosis and analysis by GeneXpert assay. Confirmed Mycobacterium tuberculosis in a positive culture was used as a referen

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Huey, Lee Lih, Chua Wei Chuan, Zeti Norfidiyati Ayub Salmuna, Norazmi Mohd Nor, Alwi Muhd Besari and Chan, and Yean Yean. "A novel two-codon deletion at codon 508 and 509 of the rpoB gene in pulmonary tuberculosis and HIV co-infection: A case report." Pakistan Journal of Medical and Health Sciences 16, no. 7 (2022): 201–2. http://dx.doi.org/10.53350/pjmhs22167201.

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We report a case of pulmonary Mycobacterium tuberculosis infection with a resistance to rifampicin (RIF) in a 39-year-old man who was co-infected with Human Immunodeficiency Virus (HIV) and hepatitis C. Phenotypic and genotypic test were performed to diagnose the patient. Sequencing analysis revealed novel two-codon deletion at codon 508 and 509 of the rpoB gene in M. tuberculosis. Keywords: Co-infection, Mycobacterium tuberculosis, rpoB gene, rifampicin-resistant.

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Laskar, Nourjahan, Md Akram Hossain, Jannatul Fardows, and Mominur Rahman. "GeneXpert MTB/RIF Assay for Rapid Identification of Mycobacterium Tuberculosis and Rifampicin Resistance Directly from Sputum Sample." Journal of Enam Medical College 7, no. 2 (2017): 86–89. http://dx.doi.org/10.3329/jemc.v7i2.32653.

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Background: The World Health Organization has endorsed the use of molecular methods for the detection of tuberculosis (TB) and drug resistant TB as a rapid method. In Bangladesh, the Xpert MTB/RIF assay has been implemented into reference laboratories for diagnosis of TB and also MDR TB.Objective: Drug resistant tuberculosis has long been a common problem prevailing in our country. The present study focused on the rapid identification of Mycobacterium tuberculosis as well as drug resistance.Materials and Methods: Sputum samples from a total of 107 cases, assumed as multi-drug resistance tuberc

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Tesic, Jelena, Zorica Lepsanovic, and Veljko Mirovic. "Evaluation of usefulness of single-strand conformation polymorphism method for rapid detection of rifampicin-resistant mycobacterium tuberculosis." Vojnosanitetski pregled 61, no. 2 (2004): 169–72. http://dx.doi.org/10.2298/vsp0402169t.

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The aim was to evaluate the Single-Strand Conformation Polymorphism method as a potential tool for rapid detection of rifampicin-resistant strains by the use of 39 rifampicin-resistant Mycobacterium tuberculosis strains isolated in Serbia. SSCP analysis on acrylamide gel detected 56.4% of the rifampicin-resistant M. tuberculosis strains and showed the inability to detect one of the most frequent mutations, TCG?TTG mutation in codon 531 of the rpoB gene, which was shown by automated sequencing.

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Riwu, Audrey Gracelia, Jusak Nugaraha, and Yoes Prijatna Dachlan. "DIFFERENCES OF INTERLEUKIN-18 AND INTERLEUKIN-10 LEVELS IN RIFAMPICIN RESISTANT AND RIFAMPICIN SENSITIVE PULMONARY TUBERCULOSIS PATIENTS IN DR. SOETOMO HOSPITAL SURABAYA." Indonesian Journal of Tropical and Infectious Disease 8, no. 2 (2020): 116. http://dx.doi.org/10.20473/ijtid.v8i2.10959.

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Rifampicin is an anti-tuberculosis drug which has an efficient antimicrobial effect and the basis of a short-term treatment regimen for tuberculosis (TB) patients. Rifampicin plays an important role against the growth and slow metabolism of Bacilli M. tuberculosis. Resistance to rifampicin causes the duration of tuberculosis treatment to be longer. Interleukin-18 (IL-18) is a pro-inflammatory cytokine which plays a role in controlling the growth of M. tuberculosis through its ability to induce IFN-γ, while Interleukin-10 (IL-10) is an anti-inflammatory cytokine which plays a role in limiting t

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Le, Xiaoqin, Xueqin Qian, Li Liu, et al. "Trends in and Risk Factors for Drug Resistance in Mycobacterium tuberculosis in HIV-Infected Patients." Viruses 16, no. 4 (2024): 627. http://dx.doi.org/10.3390/v16040627.

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Trends in and risk factors for drug resistance in Mycobacterium tuberculosis (M. tuberculosis) in human immunodeficiency virus (HIV)-infected patients with active tuberculosis were analyzed. The clinical data of M. tuberculosis and HIV-coinfected patients treated at the Shanghai Public Health Clinical Center between 2010 and 2022 were collected. The diagnosis of tuberculosis was confirmed by solid or liquid culture. The phenotypic drug susceptibility test was carried out via the proportional method, and the resistance to first-line and second-line drugs was analyzed. Logistic regression analys

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Jiang, Haiqin, Lemuel Tsang, Hongsheng Wang, and Changhong Liu. "IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses." Journal of Immunology Research 2021 (October 20, 2021): 1–12. http://dx.doi.org/10.1155/2021/5599408.

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Interferon-induced protein 44-like (IFI44L) gene is a type I interferon-stimulated gene (ISG) that plays a critical role in antiviral activity and constitutes a promising diagnostic marker. However, its precise role and function in tuberculosis have not been unveiled. This study showed that IFI44L acts as an antimicrobial target and positive modulator in human macrophages. Knockdown of IFI44L led to increased Mycobacterium tuberculosis intracellular survival. Moreover, IFI44L was significantly upregulated, and it restricted the intracellular survival of M. tuberculosis H37Rv strains at 72 h af

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Zeng, Sheng, Dong Yang, Céline Rens, and Véronique Fontaine. "The Mycobacterium bovis BCG GroEL1 Contributes to Isoniazid Tolerance in a Dormant-Like State Model." Microorganisms 11, no. 2 (2023): 286. http://dx.doi.org/10.3390/microorganisms11020286.

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Due to the Mycobacterium tuberculosis complex, including M. tuberculosis and M. bovis, tuberculosis still causes 1.6 million deaths per year. Therefore, efforts to improve tuberculosis treatment are necessary. We previously showed that the GroEL1 protein is involved in antibiotic intrinsic resistance. Indeed, the M. bovis BCG cpn60.1 gene (encoding GroEL1)-disrupted strain (Δcpn60.1) exhibits higher rifampicin and vancomycin susceptibility due to defective cell wall integrity. Here, we show that during hypoxia-triggered growth stasis, in the Wayne dormancy model, the mutant exhibited comparabl

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Sabaté, M. Betriu, A. González-Rodríguez, A. Guàrdia, et al. "Pharmacokinetic interactions of psychotropic medications in patients with schizophrenia suffering from atypical mycobacterial infections." European Psychiatry 64, S1 (2021): S649—S650. http://dx.doi.org/10.1192/j.eurpsy.2021.1725.

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IntroductionMycobacterium kansasii is a nontuberculous mycobacterium that causes infection associated with past or current tuberculosis disease. Clinical syndromes and radiological findings are mostly indistinguishable from that of Mycobacterium tuberculosis, thus requiring microbiological confirmation.ObjectivesWe report a case of a 44-year-old man diagnosed with schizophrenia and Mycobacterium kansasii infection.MethodsCase report and non-systematic narrative review from PubMed.ResultsCase report: Patient with schizophrenia who was admitted at the inpatient unit presenting psychotic exacerba

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Widodo, Widodo, Daniel Joko Wahyono, Oedjijono Oedjijono, and Hendro Pramono. "Regional Variations in rpoB Gene Mutations and Their Association with Rifampicin Resistance in Mycobacterium tuberculosis." Molekul 20, no. 1 (2025): 137. https://doi.org/10.20884/1.jm.2025.20.1.13215.

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ABSTRACT. The increasing incidence of tuberculosis (TB) remains a global challenge, driven by the emergence of Mycobacterium tuberculosis resistance to antituberculosis drugs. This study investigated the relationship between rpoB gene mutations, rifampicin resistance levels, and the geographic origin of multidrug-resistant M. tuberculosis (MDR-TB) isolates. A total of 30 MDR-TB isolates were collected from the Central Java Provincial Health and Calibration Testing Laboratory between January and December 2023. Rifampicin resistance levels ranged from 5 to 80 µg/mL and were assessed using the mi

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Rahman, Fahmida, Sadia Sharmin, Md Mustafa Kamal, and Md Ruhul Amin Miah. "Drug resistance pattern of M. tuberculosis in category II treatment failure pulmonary tuberculosis patients." Ibrahim Medical College Journal 7, no. 1 (2014): 9–11. http://dx.doi.org/10.3329/imcj.v7i1.17741.

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This study was designed to determine the extent of drug resistance of M. tuberculosis (MTB) isolated from category II treatment failure pulmonary tuberculosis (PTB) patients. A total of 100 Ziehl-Neelsen (Z-N) smear positive category II failure PTB patients were included in this study. Sputum culture was done in Lowenstein-Jensen (L-J) media. Conventional proportion method on Lowenstein-Jensen (L-J) media was used to determine the drug susceptibility of M. tuberculosis to isoniazid (INH), rifampicin (RMP), ofloxacin (OFX) and kanamycin (KA). Out of 100 sputum samples, a total of 87 samples wer

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Coban, Ahmet Yilmaz. "A novel agar base medium for drug susceptibility testing of Mycobacterium tuberculosis isolates." Future Microbiology 16, no. 13 (2021): 949–53. http://dx.doi.org/10.2217/fmb-2021-0032.

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Aim: In this study, it was aimed to evaluate AYC.2.2 agar for susceptibility testing of Mycobacterium tuberculosis clinical isolates against first-line drugs. Materials & methods: In the present study, 208 M. tuberculosis clinical isolates were tested on AYC.2.2 agar, which was previously validated for the first-line drugs isoniazid, rifampicin, streptomycin and ethambutol. Results: Specificity, sensitivity, positive predictive value, negative predictive value and agreement for isoniazid–rifampicin–ethambutol–streptomycin were 100–100–97.2–99.3%, 94.8–94.8–79.3–94.3%, 100–100–82.1–98.03%,

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Garg, Saurabh, Rakesh Kumar, Dennis Kunimoto, and Gina R. Rayat. "Anti-Mycobacterial Activity of Flavonoid and Pyrimidine Compounds." Molecules 27, no. 19 (2022): 6714. http://dx.doi.org/10.3390/molecules27196714.

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We evaluated the anti-mycobacterial effect of a flavonoid 5,7-dihydroxy-2-(4-hydroxyphenyl) 4H-chromen-4-one (1) and two pyrimidines, 4-hydroxy-2-dimethylamino-5-nitroso-6-aminopyrimidine (2) and 2-chloro-5-n-nonylpyrimidine (3) in vitro against Mycobacterium tuberculosis (M. tuberculosis, H37Ra) and Mycobacterium avium (M. avium), using a Microplate Alamar Blue Assay (MABA). The effects of the compounds 1–3 in combination with first- and second-line anti-TB drugs isoniazid, rifampicin, cycloserine, and clarithromycin on the growth of M. tuberculosis and M. avium were also evaluated in in vitr

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Murthy, Neetha S., Sanjeev Nair, PK Ramya, et al. "Drug-resistant Tuberculosis: First Line Drug Resistance Pattern among Mycobacterium Tuberculosis Strains Isolated from a Reference Laboratory in Kerala State, India." Journal of Pure and Applied Microbiology 15, no. 4 (2021): 1882–91. http://dx.doi.org/10.22207/jpam.15.4.09.

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Resistance to antimycobacterial agents consistently remains a major obstacle to end TB in India. Geographical prevalence data regarding drug-resistant evolutionary genetics of M. tuberculosis (MTB) remains sparse in India. Our objective was to determine the genotypic drug resistance mutation pattern for Rifampicin and Isoniazid of MTB isolates to gain an understanding of the prevailing molecular epidemiology of drug-resistant tuberculosis. In this study 2528 M. tuberculosis DNA isolates from presumptive DRTB suspects received at the nodal TB reference laboratory in Kerala were tested for Rifam

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Kumar Sah, Ranjit, Dwij Raj Bhatta, Gokarna Raj Ghimire, Bhuwaneswor Prasad Kandel, Bishnu Raj Tiwari, and Jeevan Bahadur Sherchand. "Evaluation of Nitrate Reductase Assay For Rapid Detection of Drug Resistant Tuberculosis." Journal of Health and Allied Sciences 3, no. 1 (2019): 44–46. http://dx.doi.org/10.37107/jhas.53.

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Emergence of multidrug-resistant tuberculosis (MDR-TB) urgently demands for simple, rapid and inexpensive methods of its detection for the effective treatment of drug resistant tuberculosis, particularly in low-income countries. This prospective study was carried out at National Tuberculosis Reference Laboratory and South Asian Association of Regional Cooperation (SAARC) Tuberculosis and HIV/AIDS Centre, Thimi, Bhaktapur, Nepal, from November 2009 to May 2010 to evaluate nitrate reductase assay (NRA) efficacy for rapid determination of streptomycin, isoniazid, rifampicin and ethambutol suscept

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Zhurilo, A. A., A. I. Barbova, Yu A. Cherednik, et al. "COMPARISON OF GENEXPERT MTB/RIF AND GENOTYPE SYSTEMS WITH MTBDRPLUS STRIPS FOR DETECTION OF MUTATIONS THAT ARE ASSOCIATED WITH M. TUBERCULOSIS RESISTANCE TO RIFAMPICIN IN TUBERCULOSIS." Ukrainian Pulmonology Journal 30, no. 4 (2022): 34–41. http://dx.doi.org/10.31215/2306-4927-2022-30-4-34-41.

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COMPARISON OF GENEXPERT MTB/RIF AND GENOTYPE SYSTEMS WITH MTBDRPLUS STRIPS FOR DETECTION OF MUTATIONS, ASSOCIATED WITH M. TUBERCULOSIS RESISTANCE TO RIFAMPICIN IN TUBERCULOSIS A. A. Zhurilo, A. I. Barbova, Yu. A. Cherednik, P. S. Trofi mova, S. V. Mironchenko, O. V. Pavlova, A. V. Chernov, L. M. Sladkova Summary The aim was to analyze the level of compliance of two molecular genetic methods GeneXpert MTB/RIF and GenoTypeDRplus in determining the drug resistance of M. tuberculosis to rifampicin when detecting mutations in the RRDR region associated with drug resistance. Object and methods. We s

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Sah, Ranjit Kumar, DR Bhatta, GR Ghimire, BP Kandel, BR Tiwari, and JB Sherchand. "Evaluation of Nitrate Reductase Assay for Rapid Detection of Drug Resistant Tuberculosis." SAARC Journal of Tuberculosis, Lung Diseases and HIV/AIDS 9, no. 2 (2013): 4–8. http://dx.doi.org/10.3126/saarctb.v9i2.7971.

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Introduction: Emergence of multidrug-resistant tuberculosis (MDR-TB) urgently demands for simple, rapid and inexpensive methods of its detection for the effective treatment of drug resistant tuberculosis, particularly in low-income countries. Methodology: This prospective study was carried out at National Tuberculosis Reference Laboratory and South Asian Association of Regional Cooperation (SAARC) Tuberculosis and HIV/AIDS Centre, Thimi, Bhaktapur, Nepal, from November 2009 to May 2010 to evaluate nitrate reductase assay (NRA) efficacy for rapid determination of streptomycin, isoniazid, rifamp

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Andreevskaya, S. N., T. G. Smirnova, E. E. Larionova, I. Yu Andrievskaya, L. N. Chernousova, and A. Ergeshov. "Isoniazid-resistant Mycobacterium tuberculosis: prevalence, resistance spectrum and genetic determinants of resistance." Bulletin of Russian State Medical University, no. (1)2020 (January 12, 2020): 21–26. http://dx.doi.org/10.24075/brsmu.2020.001.

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The lack of simple, rapid diagnostic tests for isoniazid-resistant rifampicin-susceptible tuberculosis infection (Hr-TB) can result in low treatment efficacy and further amplification of drug resistance. Based on the clinical data, this study sought to estimate the prevalence of Hr-TB in the general population and characterize the phenotypic susceptibility and genetic determinants of isoniazid resistance in M. tuberculosis strains. Molecular-genetic and culture-based drug susceptibility tests were performed on M. tuberculosis isolates and M. tuberculosis DNA obtained from the patients with pul

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Santos, Nathally C. de S., Regiane B. de L. Scodro, Dayane CB Leal, et al. "Determination of minimum bactericidal concentration, in single or combination drugs, against Mycobacterium tuberculosis." Future Microbiology 15, no. 2 (2020): 107–14. http://dx.doi.org/10.2217/fmb-2019-0050.

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Aim: To evaluate an assay to detect minimum bactericidal concentration (MBC) in Mycobacterium tuberculosis, using as single model rifampicin, isoniazid, levofloxacin (LVX) and linezolid (LNZ) and in combination. Material & methods: MBCs were carried out directly from resazurin microtiter assay plate and 3D checkerboard in M. tuberculosis H37Rv and five resistant clinical isolates. Results: The proposed MBC assay showed similar values to those determined by MGIT™, used as control. LVX and LNZ's MBC values were close to their MIC values. LNZ or LVX combined with isoniazid and rifampicin show

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Suhas Kulkarni, Gauri, and Chetan Mahajan. "Resistance to Isoniazid and Rifampicin and Factors Associated with Resistance Among MDR TB Patients Visiting DOTS PLUS Site." MVP Journal of Medical Sciences 4, no. 1 (2017): 14. http://dx.doi.org/10.18311/mvpjms/0/v0/i0/14782.

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Introduction: Multidrug-Resistant (MDR-TB) is defined as M tuberculosis resistant to isoniazid and rifampicin with or without resistant to other drugs. Drug resistant TB is known to occur from time of introduction of antituberculosis drugs. MDR TB has become a significant health problem and an obstacle to effective TB control1. Resistance of M. tuberculosis to anti- TB drugs is caused by chromosomal mutations in genes encoding drug targets. Multidrug-resistant strains of M. tuberculosis (MDR-TB) evolve due to sequential accumulation of mutations in target genes. The WHO cites TB as the single

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Dr., Muhammad Naseer ud Din Dr. Komal Rubab Dr. Shabana Amir. "A CROSS-SECTIONAL RESEARCH ON SUSCEPTIBILITY PATTERN OF MYCOBACTERIUM TUBERCULOSIS (MTB) IN SPUTUM SAMPLES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 07 (2018): 6896–902. https://doi.org/10.5281/zenodo.1323763.

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<strong><em>Objective: </em></strong><em>The research was aimed at knowing the</em><em> drugs susceptibility pattern in (MTB) i.e. Mycobacterium Tuberculosis in the attendants of multi-drug resistant tuberculosis patients.</em> <strong><em>Methods & Material: </em></strong><em>The research was performed at </em><em>Services Hospital, Lahore (August, 16 to March, 17). The research was cross-sectional in that 480 sputum samples from the patients of MDR-TB attendants were under taken for identification of (M. TB). It was performed by Ziehl Neelsen staining, i.e. (BACTEC MGIT-960 culture) line

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Al-Mutairi, Noura M., Suhail Ahmad, Eiman Mokaddas, and Sahal Al-Hajoj. "First insights into the phylogenetic diversity of Mycobacterium tuberculosis in Kuwait and evaluation of REBA MTB-MDR assay for rapid detection of MDR-TB." PLOS ONE 17, no. 10 (2022): e0276487. http://dx.doi.org/10.1371/journal.pone.0276487.

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Early detection of Mycobacterium tuberculosis (Mtb) in clinical specimens, its susceptibility to anti-TB drugs and disruption of infection transmission to new hosts are essential components for global tuberculosis (TB) control efforts. This study investigated major Mtb genotypes circulating in Kuwait and evaluated the performance of REBA MTB-MDR (REBA) test in comparison to GenoType MTBDRplus (gMTBDR+) assay for rapid detection of resistance of Mtb to isoniazid and rifampicin (MDR-TB). M. tuberculosis isolates (n = 256) originating predominantly from expatriate patients during a 6-month period

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Al-Madhagi, Anwar K., Khaled A. Al-Moyed, and Ahmed M. Al-Haddad. "Resistance of anti-tuberculosis drugs among pulmonary tuberculosis patients in Yemen." Journal of the Faculty of Medicine Baghdad 55, no. 3 (2013): 250–53. http://dx.doi.org/10.32007/jfacmedbagdad.553625.

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Background: Tuberculosis (TB) is still a major global public health problem worldwide. The global prevalence of Mycobacterium (M tuberculosis) infection has been estimated in 32% of the world population with more than 8 million new cases diagnosed each year. Materials and Methods: A total of 192 M tuberculosis complex isolates were collected from patients with positive sputum smear who had been treated previously with the four main anti- tuberculosis drugs for more than two months. The isolates were identified by their colonial morphology, pigmentation, shapes on Ziehl-Neelsen smears, gr

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B.M., Mahmudul Hasan. "Molecular mechanisms of action and resistance to the first-line drugs against Mycobacterium tuberculosis." International Journal of Biosciences (IJB) 24, no. 5 (2024): 38–49. https://doi.org/10.12692/ijb/24.5.38-49.

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Tuberculosis, caused by the infectious pathogenic bacteria <em>Mycobacterium tuberculosis</em>, is one of the top 10 infectious agents (above AIDS/HIV) that cause death globally, and a large number of people contract the disease every year. Significantly, the four first-line drugs (rifampicin, isoniazid, pyrazinamide, and ethambutol) that make up the foundation of treatment regimens throughout the first six to nine months of treatment are delivered in various combinations when administering TB treatments. It is very important to continuously update information on molecular mechanisms of a

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Solari, L., D. Santos-Lazaro, and Z. M. Puyen. "Mutations in Mycobacterium tuberculosis Isolates with Discordant Results for Drug-Susceptibility Testing in Peru." International Journal of Microbiology 2020 (April 7, 2020): 1–5. http://dx.doi.org/10.1155/2020/8253546.

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Evaluation of resistance to antituberculosis drugs is routinely performed with genotypic or phenotypic methods; however, discordance can be seen between these different methodologies. Our objective was to identify mutations that could explain discordant results in the evaluation of susceptibility to rifampicin and isoniazid between molecular and phenotypic methods, using whole genome sequencing (WGS). Peruvian strains showing sensitive results in the GenoType MTBDRplus v2.0 test and resistant results in the proportions in the agar-plaque test for isoniazid or rifampin were selected. Discordanc

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Belyaev, D. V., T. V. Umpeleva, D. V. Dianov, L. S. Lavrenchuk, T. Yu Boteva, and D. V. Vakhrusheva. "Phenotypic Resistance to Rifampicin of Mycobacterium tuberculosis with the rpoB Leu430Pro Mutation." Tuberculosis and Lung Diseases 102, no. 5 (2024): 64–69. http://dx.doi.org/10.58838/2075-1230-2024-102-5-64-69.

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The objective: to determine the role of the rpoB Leu430Pro mutation in the degree of phenotypic resistance of Mycobacterium tuberculosis to rifampicin.Subjects and Methods. The WHO classifies the rpoB Leu430Pro mutation of Mycobacterium tuberculosis as a borderline resistance mutation but of clinical significance. From an array of cultures, we selected and analyzed 14 isolates of M. tuberculosis with discrepancies in the results of molecular genetic and phenotypic testing, carrying only this mutation in rpoB. For all samples, the phenotypic resistance level (MIC) of these isolates to rifampici

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Salina, T. Yu, and T. I. Morozova. "Prevalence and Patterns of Gene Mutations Associated with <i>M. tuberculosis</i> Resistance to Isoniazid and Rifampicin in Patients with Different Clinical Manifestations of Tuberculosis." Tuberculosis and Lung Diseases 101, no. 1 (2023): 28–33. http://dx.doi.org/10.58838/2075-1230-2023-101-1-28-33.

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The objective: to study prevalence and patterns of mutations in the katG, inhA, ahpC, rpoB genes associated with Mycobacterium tuberculosis (MTB) resistance to isoniazid (H) and rifampicin (R) in patients with various clinical manifestations of pulmonary tuberculosis (TB).Subjects and Methods. 441 sputum samples collected in tuberculosis patients were tested using biological microchips. Tests were carried out in Group 1 - patients with confirmed bacterial excretion (n = 256) and in Group 2 (n = 185) - patients without bacterial excretion. The same patients were enrolled in Group 3 - patients w

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Lumb, Richard, Ivan Bastian, David Dawson, et al. "Tuberculosis in Australia: bacteriologically confirmed cases and drug resistance, 2001." Communicable Diseases Intelligence 27 (June 30, 2003): 173–80. https://doi.org/10.33321/cdi.2003.27.41.

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The Australian Mycobacterium Reference Laboratory Network collected and analysed laboratory data on new cases of disease caused by Mycobacterium tuberculosis complex in the year 2001. A total of 771 cases were identified, representing an annual reporting rate of 4.0 cases of laboratory-confirmed tuberculosis per 100,000 population. The predominant specimen type was sputum, (n=369) and a further 111 were collected at bronchoscopy. Smears were positive for 214 of 369 (58.0%) sputum and 42 of 111 (37.8%) bronchoscopy specimens respectively. Seven children (male n=5, female n=2) under 10 years of

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Krajewska-Wędzina, Monika, Anna Zabost, Ewa Augustynowicz-Kopeć, Marcin Weiner, and Krzysztof Szulowski. "Evaluation of susceptibility to antimycobacterial drugs in Mycobacterium tuberculosis complex strains isolated from cattle in Poland." Journal of Veterinary Research 61, no. 1 (2017): 23–26. http://dx.doi.org/10.1515/jvetres-2017-0003.

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Abstract Introduction: Tuberculosis is a highly infectious disease affecting humans and animals. It is caused by the Mycobacterium tuberculosis complex (MTBC) – Mycobacterium bovis and Mycobacterium caprae, which are aetiological factors of bovine tuberculosis (bTB). In Poland, the bTB eradication programme exists. Animals diagnosed with tuberculosis are in the majority of cases not treated, but removed from their herd and then sanitary slaughtered. Material and Methods: In total, 134 MTBC strains isolated from cattle in Poland were subjected to microbiological analysis. The resistance phenoty

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Caminero, Jose, and Charles Daley. "Management of Multidrug-Resistant Tuberculosis." Seminars in Respiratory and Critical Care Medicine 39, no. 03 (2018): 310–24. http://dx.doi.org/10.1055/s-0038-1661383.

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AbstractDrug-resistant strains of Mycobacterium tuberculosis pose a major threat to global tuberculosis control. Despite the availability of curative antituberculosis therapy for nearly half a century, inappropriate and inadequate treatment of tuberculosis, as well as unchecked transmission of M. tuberculosis, has resulted in alarming levels of drug-resistant tuberculosis. The World Health Organization (WHO) estimates that there were 600,000 cases of multidrug-resistant tuberculosis (MDR-TB)/rifampin-resistant (RR) tuberculosis in 2016, defined as strains that are resistant to at least isoniaz

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Warryn, Louisa, and Gerd Pluschke. "Repurposing of Tuberculosis Drug Candidates for the Treatment of Mycobacterium ulcerans Disease." CHIMIA 77, no. 9 (2023): 577. http://dx.doi.org/10.2533/chimia.2023.577.

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Buruli ulcer (BU) is a chronic necrotizing skin disease caused by Mycobacterium ulcerans. Historically, the disease was treated by surgical excision of the skin lesions, until an 8-week combination therapy of rifampicin and streptomycin was introduced in 2004. This treatment modality was effective and reduced recurrence rates. Rifampicin is the most efficacious antibiotic for the treatment of BU and, should rifampicin-resistant M. ulcerans strains emerge, there is currently no replacement for it. As for mycobacterial diseases in general, there is a pressing need for the development of novel, f

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Admassu, Wasihun, Birhanu Ayelign, Gemeda Abebe, and Mulualem Tadesse. "Detection of Mycobacterium tuberculosis and rifampicin resistance by Xpert® MTB/RIF assay among presumptive tuberculosis cases at Jimma University Medical Center, Southwest Ethiopia." PLOS ONE 17, no. 1 (2022): e0262929. http://dx.doi.org/10.1371/journal.pone.0262929.

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Background Rapid diagnosis of tuberculosis (TB) and detection of drug resistance are very important for timely and appropriate management of patients. Xpert MTB/RIF assay is approved for use in TB and rifampicin-resistance diagnosis. However, data are limited on the impact of Xpert MTB/RIF assay under routine clinical settings with a heterogeneous group of patients and sample types in Ethiopia. Methods A retrospective study was carried out in 2220 presumptive TB cases at Jimma University Medical Center. Data were gathered from the registration logbook using formatted data extraction tools and

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MADANIA, AMMAR, MAYA HABOUS, HANA ZARZOUR, IFAD GHOURY, and BAREA HEBBO. "Characterization of Mutations Causing Rifampicin and Isoniazid Resistance of Mycobacterium tuberculosis in Syria." Polish Journal of Microbiology 61, no. 1 (2012): 23–32. http://dx.doi.org/10.33073/pjm-2012-003.

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In order to characterize mutations causing rifampicin and isoniazid resistance of M. tuberculosis in Syria, 69 rifampicin resistant (Rif(r)) and 72 isoniazid resistant (Inh(r)) isolates were screened for point mutations in hot spots of the rpoB, katG and inhA genes by DNA sequencing and real time PCR. Of 69 Rif(r) isolates, 62 (90%) had mutations in the rifampin resistance determining region (RRDR) of the rpoB gene, with codons 531 (61%), 526 (13%), and 516 (8.7%) being the most commonly mutated. We found two new mutations (Asp516Thr and Ser531Gly) described for the first time in the rpoB-RRDR

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Kalani, Komal, Vinita Chaturvedi, Priyanka Trivedi, Sudeep Tondon, and Santosh Kumar Srivastava. "Dihydroartemisinin and its Analogs: A New Class of Antitubercular Agents." Current Topics in Medicinal Chemistry 19, no. 8 (2019): 594–99. http://dx.doi.org/10.2174/1568026619666190304142802.

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Background: Tuberculosis is one of the leading causes of mortality worldwide. Resistance against the frontline anti-tubercular drugs has worsened the already alarming situation, which requires intensive drug discovery to develop new, more effective, affordable and accessible anti-tubercular agents possessing novel modes of action. Objective: Chemical transformation of dihydroartemisinin for anti-tubercular lead optimization. Methods: Dihydroartemisinin, a metabolite of artemisinin was chemically converted into eight acyl derivatives and were evaluated for anti-tubercular potential against H37R

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Umpeleva, T. V., E. A. Mazurina, D. V. Vakhrusheva, and N. I. Eremeeva. "Comparison of Different Methods for Drug Susceptibility Testing of Mycobacterium tuberculosis to Rifampicin." Tuberculosis and Lung Diseases 100, no. 1 (2022): 41–48. http://dx.doi.org/10.21292/2075-1230-2022-100-1-41-48.

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The objective: to compare results of drug susceptibility testing to rifampicin by molecular genetic methods and phenotypic tests of Mycobacterium tuberculosis isolates obtained from clinical specimens of tuberculosis patients.Subjects and Methods. 915 samples of M. tuberculosis DNA and 426 cultures were used in this study. Genotypic tests (TB-TEST (BIOCIP-IMB, Russia), GenoType MTBDRplusV2) and phenotypic technologies (absolute concentration method, Bactec MGIT 960 system, Sensititre Myco TB kit) were used.Results. A high percentage (98.7%; CI 97.7-99.7%) of confirmation of the results of the

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Diriba, Getu, Abebaw Kebede, Habteyes Hailu Tola, et al. "Utility of line probe assay in detecting drug resistance and the associated mutations in patients with extrapulmonary tuberculosis in Addis Ababa, Ethiopia." SAGE Open Medicine 10 (January 2022): 205031212210982. http://dx.doi.org/10.1177/20503121221098241.

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Introduction: Molecular tests allow rapid detection of Mycobacterium tuberculosis and drug resistance in a few days. Identifying the mutations in genes associated with drug resistance may contribute to the development of appropriate interventions to improve tuberculosis control. So far, there is little information in Ethiopia about the diagnostic performance of line probe assay (LPA) and the M. tuberculosis common gene mutations associated with drug resistance in extrapulmonary tuberculosis. Thus, this study aimed to assess the frequency of drug resistance-associated mutations in patients with

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Mushtaq, Fizza, Syed Mohsin Raza, Adeel Ahmad, et al. "Antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure." PLOS ONE 18, no. 10 (2023): e0293194. http://dx.doi.org/10.1371/journal.pone.0293194.

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Tuberculosis stands as a prominent cause of mortality in developing countries. The treatment of tuberculosis involves a complex procedure requiring the administration of a panel of at least four antimicrobial drugs for the duration of six months. The occurrence of treatment failure after the completion of a standard treatment course presents a serious medical problem. The purpose of this study was to evaluate antimicrobial drug resistant features of Mycobacterium tuberculosis associated with treatment failure. Additionally, it aimed to evaluate the effectiveness of second line drugs such as am

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Sanzhakov, M. A., O. M. Ipatova, V. N. Prozorovskiy, N. V. Medvedeva, and T. I. Torkhovskaya. "Interaction of rifampicin embedded in phospholipid nanoparticles with blood plasma lipoproteins." Biomeditsinskaya Khimiya 60, no. 3 (2014): 348–53. http://dx.doi.org/10.18097/pbmc20146003348.

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The drug formulations of antituberculous remedy rifampicin in nanoparticles less than 30 nm based on soy phosphatidylcholine and sodium oleate was elaborated in Institute of Biomedical Chemistry. The distribution of rifampicin in blood plasma fractions after incubation with this formulation and with free rifampicin was studied. This goal was stimulated by the literature data about activation of macrophages LDL receptors in cases of M. tuberculosis infection. Plasma was incubated 30 min with free rifampicin or rifampicin encapsulated into the nanoformulation followed by ultracentrifugation and

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Kazakova, Oxana, Roxana Racoviceanu, Anastasiya Petrova, et al. "New Investigations with Lupane Type A-Ring Azepane Triterpenoids for Antimycobacterial Drug Candidate Design." International Journal of Molecular Sciences 22, no. 22 (2021): 12542. http://dx.doi.org/10.3390/ijms222212542.

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Twenty lupane type A-ring azepano-triterpenoids were synthesized from betulin and its related derivatives and their antitubercular activity against Mycobacterium tuberculosis, mono-resistant MTB strains, and nontuberculous strains Mycobacterium abscessus and Mycobacterium avium were investigated in the framework of AToMIc (Anti-mycobacterial Target or Mechanism Identification Contract) realized by the Division of Microbiology and Infectious Diseases, NIAID, National Institute of Health. Of all the tested triterpenoids, 17 compounds showed antitubercular activity and 6 compounds were highly act

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