Relevant bibliographies by topics / M1 mAChRs

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  1. Journal articles
  2. Dissertations / Theses
  3. Conference papers

Academic literature on the topic 'M1 mAChRs'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "M1 mAChRs"

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Dasari, Sameera, and Allan T. Gulledge. "M1 and M4 Receptors Modulate Hippocampal Pyramidal Neurons." Journal of Neurophysiology 105, no. 2 (2011): 779–92. http://dx.doi.org/10.1152/jn.00686.2010.

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Acetylcholine (ACh), acting at muscarinic ACh receptors (mAChRs), modulates the excitability and synaptic connectivity of hippocampal pyramidal neurons. CA1 pyramidal neurons respond to transient (“phasic”) mAChR activation with biphasic responses in which inhibition is followed by excitation, whereas prolonged (“tonic”) mAChR activation increases CA1 neuron excitability. Both phasic and tonic mAChR activation excites pyramidal neurons in the CA3 region, yet ACh suppresses glutamate release at the CA3-to-CA1 synapse (the Schaffer–collateral pathway). Using mice genetically lacking specific mAC
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Kullmann, F. Aura, D. Artim, J. Beckel, S. Barrick, W. C. de Groat, and L. A. Birder. "Heterogeneity of muscarinic receptor-mediated Ca2+ responses in cultured urothelial cells from rat." American Journal of Physiology-Renal Physiology 294, no. 4 (2008): F971—F981. http://dx.doi.org/10.1152/ajprenal.00313.2007.

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Muscarinic receptors (mAChRs) have been identified in the urothelium, a tissue that may be involved in bladder sensory mechanisms. This study investigates the expression and function of mAChRs using cultured urothelial cells from the rat. RT-PCR established the expression of all five mAChR subtypes. Muscarinic agonists acetylcholine (ACh; 10 μM), muscarine (Musc; 20 μM), and oxotremorine methiodide (OxoM; 0.001–20 μM) elicited transient repeatable increases in the intracellular calcium concentration ([Ca2+]i) in ∼50% of cells. These effects were blocked by the mAChR antagonist atropine methyl
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Kohlmeier, Kristi A., Masaru Ishibashi, Jürgen Wess, Martha E. Bickford, and Christopher S. Leonard. "Knockouts reveal overlapping functions of M2 and M4 muscarinic receptors and evidence for a local glutamatergic circuit within the laterodorsal tegmental nucleus." Journal of Neurophysiology 108, no. 10 (2012): 2751–66. http://dx.doi.org/10.1152/jn.01120.2011.

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Cholinergic neurons in the laterodorsal tegmental (LDT) and peduncolopontine tegmental (PPT) nuclei regulate reward, arousal, and sensory gating via major projections to midbrain dopamine regions, the thalamus, and pontine targets. Muscarinic acetylcholine receptors (mAChRs) on LDT neurons produce a membrane hyperpolarization and inhibit spike-evoked Ca2+ transients. Pharmacological studies suggest M2 mAChRs are involved, but the role of these and other localized mAChRs (M1--M4) has not been definitively tested. To identify the underlying receptors and to circumvent the limited receptor select
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Zlatopolskiy, Boris D., Felix Neumaier, Till Rüngeler, Birte Drewes, Niklas Kolks, and Bernd Neumaier. "Preparation of a First 18F-Labeled Agonist for M1 Muscarinic Acetylcholine Receptors." Molecules 25, no. 12 (2020): 2880. http://dx.doi.org/10.3390/molecules25122880.

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M1 muscarinic acetylcholine receptors (mAChRs) are abundant in postsynaptic nerve terminals of all forebrain regions and have been implicated in the cognitive decline associated with Alzheimer’s disease and other CNS pathologies. Consequently, major efforts have been spent in the development of subtype-selective positron emission tomography (PET) tracers for mAChRs resulting in the development of several 11C-labeled probes. However, protocols for the preparation of 18F-labeled mAChR-ligands have not been published so far. Here, we describe a straightforward procedure for the preparation of an
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Smith, Richard S., and Ricardo C. Araneda. "Cholinergic Modulation of Neuronal Excitability in the Accessory Olfactory Bulb." Journal of Neurophysiology 104, no. 6 (2010): 2963–74. http://dx.doi.org/10.1152/jn.00446.2010.

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The accessory olfactory bulb (AOB), the first relay of chemosensory information in the Vomeronasal system, receives extensive cholinergic innervation from the basal forebrain. Cholinergic modulation of neuronal activity in the olfactory bulb has been hypothesized to play an important role in olfactory processing; however, little is known about the cellular actions of acetylcholine (ACh) within the AOB. Here using in vitro slice preparation, we show that muscarinic acetylcholine receptor (mAChR) activation increases neuronal excitability of granule and mitral/tufted cells (GCs and MCs) in the A
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Maeda, Shoji, Jun Xu, Francois Marie N. Kadji, et al. "Structure and selectivity engineering of the M1 muscarinic receptor toxin complex." Science 369, no. 6500 (2020): 161–67. http://dx.doi.org/10.1126/science.aax2517.

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Muscarinic toxins (MTs) are natural toxins produced by mamba snakes that primarily bind to muscarinic acetylcholine receptors (MAChRs) and modulate their function. Despite their similar primary and tertiary structures, MTs show distinct binding selectivity toward different MAChRs. The molecular details of how MTs distinguish MAChRs are not well understood. Here, we present the crystal structure of M1AChR in complex with MT7, a subtype-selective anti-M1AChR snake venom toxin. The structure reveals the molecular basis of the extreme subtype specificity of MT7 for M1AChR and the mechanism by whic
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Yang, Danqing, Robert Günter, Guanxiao Qi, Gabriele Radnikow, and Dirk Feldmeyer. "Muscarinic and Nicotinic Modulation of Neocortical Layer 6A Synaptic Microcircuits Is Cooperative and Cell-Specific." Cerebral Cortex 30, no. 6 (2019): 3528–42. http://dx.doi.org/10.1093/cercor/bhz324.

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Abstract Acetylcholine (ACh) is known to regulate cortical activity during different behavioral states, for example, wakefulness and attention. Here we show a differential expression of muscarinic ACh receptors (mAChRs) and nicotinic ACh receptors (nAChRs) in different layer 6A (L6A) pyramidal cell (PC) types of somatosensory cortex. At low concentrations, ACh induced a persistent hyperpolarization in corticocortical (CC) but a depolarization in corticothalamic (CT) L6A PCs via M 4 and M1 mAChRs, respectively. At ~ 1 mM, ACh depolarized exclusively CT PCs via α4β2 subunit-containing nAChRs wit
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van Koppen, C. J. "Multiple pathways for the dynamin-regulated internalization of muscarinic acetylcholine receptors." Biochemical Society Transactions 29, no. 4 (2001): 505–8. http://dx.doi.org/10.1042/bst0290505.

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An important regulatory pathway of G-protein-coupled receptors (GPCRs) is the internalization of receptors into the cell interior. To unravel the molecular mechanisms by which GPCRs are internalized, we have studied the internalization of various members of the family of muscarinic acetylcholine receptors (mAChRs). Using the transient expression system of HEK-293 cells, we showed that the M1, M3 and M4 mAChRs are internalized into clathrin-coated vesicles and recycle back to the plasma membrane. This internalization pathway is dependent on the concerted action of β-arrestin, c-Src and the GTPa
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Yang, Jyh-Jeen, Yu-Ting Wang, Pi-Cheng Cheng, Yeh-Jung Kuo, and Rong-Chi Huang. "Cholinergic Modulation of Neuronal Excitability in the Rat Suprachiasmatic Nucleus." Journal of Neurophysiology 103, no. 3 (2010): 1397–409. http://dx.doi.org/10.1152/jn.00877.2009.

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The central cholinergic system regulates both the circadian clock and sleep-wake cycle and may participate in the feedback control of vigilance states on neural excitability in the suprachiasmatic nucleus (SCN) that houses the circadian clock. Here we investigate the mechanisms for cholinergic modulation of SCN neuron excitability. Cell-attached recordings indicate that the nonspecific cholinergic agonist carbachol (CCh) inhibited 55% and excited 21% SCN neurons, leaving 24% nonresponsive. Similar response proportions were produced by two muscarinic receptor [muscarinic acetylcholine receptor
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Yang, Qing, Andrew D. Sumner, Henry L. Puhl, and Victor Ruiz-Velasco. "M1 and M2 Muscarinic Acetylcholine Receptor Subtypes Mediate Ca2+ Channel Current Inhibition in Rat Sympathetic Stellate Ganglion Neurons." Journal of Neurophysiology 96, no. 5 (2006): 2479–87. http://dx.doi.org/10.1152/jn.00093.2006.

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Muscarinic acetylcholine receptors (mAChRs) are known to mediate the acetylcholine inhibition of Ca2+ channels in central and peripheral neurons. Stellate ganglion (SG) neurons provide the main sympathetic input to the heart and contribute to the regulation of heart rate and myocardial contractility. Little information is available regarding mAChR regulation of Ca2+ channels in SG neurons. The purpose of this study was to identify the mAChR subtypes that modulate Ca2+ channel currents in rat SG neurons innervating heart muscle. Accordingly, the modulation of Ca2+ channel currents by the muscar
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Dissertations / Theses on the topic "M1 mAChRs"

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Kim, Ju Young. "M1 muscarinic acetylcholine receptor regulation of endogenous transient receptor potential-canonical, subtype 6 (TRPC6) channels." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1117570788.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xviii, 178 p.; also includes graphics. Includes bibliographical references (p. 163-178). Available online via OhioLINK's ETD Center
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Conference papers on the topic "M1 mAChRs"

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Song, Bo, and Wing F. Ng. "Performance and Flow Characteristics of an Optimized Supercritical Compressor Stator Cascade." In ASME Turbo Expo 2005: Power for Land, Sea, and Air. ASMEDC, 2005. http://dx.doi.org/10.1115/gt2005-68569.

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An experimental and numerical study was performed on an optimized compressor stator cascade designed to operate efficiently at high inlet Mach numbers (M1) ranging from 0.83 to 0.93 (higher supercritical flow conditions). Linear cascade tests confirmed that low losses and high turning were achieved at normal supercritical flow conditions (0.7 &amp;lt; M1 &amp;lt; 0.8), as well as higher supercritical flow conditions (0.83 &amp;lt; M1 &amp;lt; 0.93), both at design and off-design incidences. The performance of this optimized stator cascade is better than those reported in the literature based o
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Steinert, W., R. Fuchs, and H. Starken. "Inlet Flow Angle Determination of Transonic Compressor Cascades." In ASME 1991 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1991. http://dx.doi.org/10.1115/91-gt-274.

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Tests of transonic compressor cascades require special measuring techniques to determine the inlet flow angle around sonic inlet flow conditions. One of the main requirements for these methods is the ability to adjust the inlet flow angle during the test to a prescribed value. A method has been successfully applied which relies on theoretically determined suction surface velocities. The described method was applied in testing cascades at inlet Mach numbers between M1=0.75–1.18. The test results confirmed the practicability of this method.
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Andrews, Gordon E., Mohamed A. Altaher, and Hu Li. "Hydrogen Combustion at High Combustor Airflow Using an Impinging Jet Flame Stabiliser With No Flashback and Low NOx." In ASME Turbo Expo 2012: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/gt2012-70052.

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The feasibility of hydrogen as a fuel for industrial gas turbines with low NOx emissions was investigated. Conventional well mixed flame stabilisers are difficult to use with 100% hydrogen owing to the flash back problem, which is potentially seven times worse for hydrogen due to its higher reactivity. This work was carried out using a rapidly mixed Jet Mix design, which had previously been investigated with NG and propane. This consisted of eight radial air jets into which the fuel was injected on their centrelines. These radial jets impinged into eight axial air jets which carried the bulk o
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Barigozzi, G., S. Ravelli, M. Maritano, and R. Abram. "Computational Predictions of Aero-Thermal Performance of a Turbine Filleted Blade Cascade With Endwall Film Cooling." In ASME Turbo Expo 2012: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/gt2012-69049.

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In this study computational fluid dynamic simulations of a turbine blade with endwall film cooling were compared to measurements of both aerodynamic and thermal performance. The experimental data were collected at low Mach number (Ma2is = 0.3) in a linear cascade arrangement with 7 blades which geometry is typical of first stage high pressure turbine. A junction between the blade hub and the platform is provided by a 3D fillet. Coolant is injected through ten cylindrical holes distributed along the blade pressure side. Coolant to mainstream mass flow ratio was set to assure an inlet blowing ra
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Weber, A., M. Faden, H. Starken, and V. Jawtusch. "Theoretical and Experimental Analysis of a Compressor Cascade at Supercritical Flow Conditions." In ASME 1987 International Gas Turbine Conference and Exhibition. American Society of Mechanical Engineers, 1987. http://dx.doi.org/10.1115/87-gt-256.

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A comparison theory - experiment in terms of profile Mach number distribution, loss behavior and exit flow angle has been made for a compressor rotor cascade at M1 = 0.85. Measurements in the cascade wind tunnel and calculations were performed over the whole incidence range. (A) A 2-D finite element method applied to the full potential equation is used as analysis code. (B) Viscous effects are considered by using McNally’s integral boundary layer method with additional procedures for laminar and turbulent separation and shock boundary layer interaction. (A) and (B) are coupled iteratively by a
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Weber, A., W. Steinert, and H. Starken. "Design and Analysis of a High Pitch to Chord Ratio Cascade Representative of Ducted Propfans." In ASME 1991 International Gas Turbine and Aeroengine Congress and Exposition. American Society of Mechanical Engineers, 1991. http://dx.doi.org/10.1115/91-gt-335.

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Efforts to reduce the specific fuel consumption of a modern aero engine focus in particular on increasing the by-pass ratio beyond the current level of around 5. One concept is the counterrotating shrouded propfan operating at low overall pressure ratio and having only very few fan blades of extremely high pitch/chord ratios. The relative inlet Mach numbers cover a range from 0.7 at the hub to 1.1 at the tip section of the first rotor. A propfan cascade was designed by taking into account two characteristic features of a propfan blade-blade section: • a very high pitch/chord ratio of s/c = 2.2
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Barigozzi, G., F. Fontaneto, G. Franchini, A. Perdichizzi, M. Maritano, and R. Abram. "Influence of Coolant Flow Rate on Aero-Thermal Performance of a Rotor Blade Cascade With Endwall Film Cooling." In ASME 2011 Turbo Expo: Turbine Technical Conference and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/gt2011-45899.

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This paper investigates the influence of coolant injection on the aerodynamic and thermal performance of a rotor blade cascade with endwall film cooling. A 7 blade cascade of a high-pressure-rotor stage of a real gas turbine has been tested in a low speed wind tunnel for linear cascades. Coolant is injected through ten cylindrical holes distributed along the blade pressure side. Tests have been preliminarily carried out at low Mach number (Ma2is = 0.3). Coolant-to-mainstream mass flow ratio has been varied in a range of values corresponding to inlet blowing ratios M1 = 0–4.0. Secondary flows h
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