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1
Qi, Chunfang. "Death penalty reform in China : international law context." Thesis, University of Central Lancashire, 2018. http://clok.uclan.ac.uk/25364/.
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This thesis provides an account of the history and the status quo of the death penalty in China, along with an analysis of its possible reform in the future. It begins by looking at the history of the use of the death penalty in China from the pre-Qin-Han era to the present. It revolves around consideration of the international law context, the drawbacks of and challenges to the Chinese legal system concerning the use of the death penalty and the would-be approaches to death penalty reform in China against the background of the global abolition movement. It examines the debates between reformists/neo-liberal cosmopolitans and conservatives in Chinese legal history from the end of the Qing dynasty to present-day China. Concerning the international law context, this thesis analyses how China treats international treaties, especially capital punishment related human rights treaties (mainly the ICCPR), on the legislative and judicial level. It studies the factors that have influenced the abolition movement in European countries. The thesis examines the Chinese Criminal Law and the Criminal Procedure Law to find challenges and gaps concerning the use of the death penalty between the Chinese legal system and the requirements of international human rights treaties. It also analyses case studies and empirical studies of capital crimes. Subsequently, the work outlines a number of alternative punishments to the death penalty and possible approaches to reform. It also analyses the present impetus for reform of the death penalty in China from a socio-economic perspective. The thesis further examines Chinese public opinion concerning the reform/abolition of the death penalty, as reflected in various surveys conducted by the author herself, as well as other Chinese or foreign scholars, for which a detailed analysis is provided in Appendix 6. Finally some possible suggestions and solutions are provided for the future reform of the death penalty in China.
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Malik, Kamran Latif. "Cloning of the propene monooxygenase genes from 'mycobacterium' M156." Thesis, Imperial College London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.243428.
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Yin, Yinan. "A comparative study on liability issues concerning maritime transportation of dangerous goods : international and Chinese perspectives." Thesis, University of Central Lancashire, 2017. http://clok.uclan.ac.uk/20926/.
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The subject of dangerous goods as it pertains to carriage by sea is of growing importance and concern because it impacts on safety as well as environmental issues. Both involve liability associated with maritime transportation and liability in respect of dangerous goods is a complex area of law both from an international as well as a domestic perspective. China is a rapidly emerging economic power and a major world player in shipping and seaborne trade including import and export of hazardous substances. Furthermore, China is undergoing remarkable reform and transformation in all respects, and legal regimes, especially in the maritime field, are in a state of evolution. This thesis presents a two-fold area of concentration, that is, the international regime and the domestic Chinese law, looking at the safety as well as the environmental dimensions of international carriage of dangerous goods by sea. In order to carry out a comparative analysis of the international and Chinese legal regimes pertaining to the issues of contractual and tortious liability, a relatively detailed analytical examination of the international regime has been completed. Following this, the legal regime under Chinese law concerning the sea carriage of dangerous goods is critically evaluated in terms of the evolution of the domestic maritime law and the issues of application of international law and domestic law from the perspectives of regulatory law and civil liability. The discussion on the existing issues liability is centered on the principles of liability in tort and contract borne by private parties and state responsibility in respect of damage arising from the maritime transportation of dangerous goods. Conclusions are drawn from the summaries of chapters highlighting the critical issues in light of the findings of the research; the appropriate recommendations and suggestions for improvements to the international regimes; and proposals for law reform in the form of new legislation or amendments to existing legislation with the aim of improving the domestic regime to bring it into closer alignment with international law on the carriage of dangerous goods by sea.
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Hinze, Stephan [Verfasser]. "Priming einer frühen elektrophysiologischen Komponente („M170“) der Gesichterverarbeitung / Stephan Hinze." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2009. http://d-nb.info/1023582406/34.
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Van, Zyl Liza Marie. "Compact interacting binaries in the core of M15." Thesis, University of Oxford, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401018.
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Hurley, Daniel Joseph Colman. "Deep CCD photometry in the globular cluster M10." Thesis, University of British Columbia, 1989. http://hdl.handle.net/2429/27480.
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CCD observations of the galactic globular cluster NGC 6254 (M10), obtained at the Canada-France-Hawaii 3.6m telescope, have been reduced and analysed. A color-magnitude diagram of the cluster which extends below V = 21 is presented. The basic observational parameters of distance modulus, reddening and metallicity are derived. The latter two values are in excellent agreement with results in the literature. The distance modulus is 0m3 larger than previous estimates. Possible implications of this discrepancy are considered. The morphology of the color-magnitude diagram, in particular the very blue horizontal branch which is observed down to the turnoff luminosity, is discussed in terms of the "second parameter" problem. The age of M10 is estimated to be 17 ± 1 Gyr, through use of Vandenberg and Bell's (1985) isochrones. A comparison to the color-magnitude diagram of NGC 288 produced by Bolte (1989b) to that of M10 indicates that these two clusters are coeval. Luminosity functions are generated for the three fields observed in M10 and translated into mass functions. By comparing those mass functions to multimass King models a global mass function exponent of x[sub global] = 0-5 ± 0.5 is found. The mass function is quite uniform in slope in the range 0.5-0.8M©. NO firm evidence for mass segregation was seen, but these data are not particularly sensitive to such effects.<br>Science, Faculty of<br>Physics and Astronomy, Department of<br>Graduate
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Alkiviadou, Natalie. "Challenging right-wing extremism in England and Wales and Greece : tools available in international, European and national law." Thesis, University of Central Lancashire, 2017. http://clok.uclan.ac.uk/18239/.
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The destructive force of the far-right was tragically witnessed through the mass devastation brought about by World War II. The international community sought to prevent the repetition of such destruction through the establishment of institutions, such as the United Nations, and the adoption of documents such as the Universal Declaration of Human Rights and the European Convention on Human Rights. Jurisprudence and conventions on a supranational level directly prohibit speech and expression of the far-right with, for example, Article 4 of the International Convention on the Elimination of All Forms of Discrimination prohibiting racist associations and racist expression. Nevertheless, we are living in a world where violent far-right entities, such as Golden Dawn of Greece, have received unprecedented electoral support, where xenophobic parties have done spectacularly well at the latest European Parliament elections, where the United Kingdom has voted to leave the European Union and where Donald Trump has been elected as the next president of the United States of America. As such, the far-right is no longer a phenomenon of the past. It is one of the present, rising at swift and worrying rates. In this light, the study analyses how supranational bodies, namely the United Nations, the Council of Europe and the European Union, require their members to tackle right-wing extremism either directly, or through the regulation of by-products of right-wing extremism, such as hate speech. The adherence to international obligations is examined through an assessment of two jurisdictions, namely, England and Wales and Greece. For purposes of this thesis, supranational obligations emanate from, inter alia, instruments such as the International Covenant on Civil and Political Rights, the International Convention on the Elimination of All Forms of Racial Discrimination and the European Convention on Human Rights. It must be noted that, on an EU level, there is also a centralised mechanism in the form of Article 7 TEU which can, in theory, be used against Member States which embrace a far-right ideology or, potentially, tolerate the far-right. However, this tool has never been used. The dissertation considers the means and methods adopted by the jurisdictions under consideration to interpret and apply international and European obligations through their national legal systems along with a broader conceptualisation of their legal and judicial approaches to right-wing extremism. The country analyses commence with an assessment of their adherence to international and European obligations, the thesis looks at the case-studies' domestic frameworks in the realm of challenging far-right movements. For both countries, there is a legal analysis of how central rights and freedoms, such as non-discrimination, expression, assembly and association, are established by law. For England and Wales, it proceeds to look at the role of criminal law in relation to the far-right, assessing the public order ambit which is the one most habitually used to challenge the rhetoric and activities of the far-right. This is followed by an evaluation of recent anti-terror legislation which has come into play in relation to the regulation of violent elements of the far-right movement. After looking at criminal law and how it deals with ensuring public order and countering terror, the assessment of England and Wales looks at how national law treats political parties before registration and during their functioning. The purpose is to determine what tools and sub-tools are available and can be used for challenging far-right parties contesting elections. From the above-described analysis, it is concluded that the legal framework of England and Wales embraces the significance of the freedom of expression but readily allows for the limitation of speech if issues of public order, terrorism or anti-social behaviour arise. Assemblies are also readily prohibited if public order or anti-social behaviour issues arise. What is clear is that this case-study is not willing to proscribe associations if such associations do not amount to terrorist organisations. In relation to Greece, the dissertation assesses the principal legal instrument that tackles issues relevant to challenging the far-right, namely the criminal law framework and particularly the law on the punishment of racially discriminatory acts, and relevant provisions of the Greek Penal Codes such as those on racial aggravation and criminal and terrorist organisations. It also look at the non-discrimination law which is relevant to this case-study given Golden Dawn's provision of services to Greeks only. It became evident from the analysis that relevant legislation has seldom been relied upon to challenge the far-right in Greece, a reality which has led to a state of impunity for the criminal activities of Golden Dawn and an issue that has become a key concern for national and international human rights institutions and non-governmental organisations. Although some members of Golden Dawn were convicted for their criminal activities and the Court recognised their affiliation with Golden Dawn, before the murder of an ethnic Greek, no steps were taken against the organisation. The chapter incorporates an analysis of the legal basis of the ongoing trial against Golden Dawn. Furthermore, the chapter also looks at how national law treats political parties before registration and during their functioning. This analysis demonstrated that political parties, even ones with dangerous and undemocratic intentions, can register and function without limitations with the only point of State intervention being when such entities cross into the threshold of a criminal organisation, as was the case of Golden Dawn.
8
Askew, Sarah Elizabeth. "Investigating the reaction specificity of alkene monooxygenase from mycobacterium sp. strain M156." Thesis, Imperial College London, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399728.
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Morash, Valerie S. (Valerie Starr). "MEG correlates of visual perception : the M170 response to degraded face and building images." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/46012.
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Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2008.<br>Includes bibliographical references (p. 35-36).<br>Introduction: Knowing how the brain processes faces is valuable to scientists, clinicians, and industry How does seeing a face eventually lead to recognition: e.g. "that's Jill." Many reports (including this one) are interested in this question, due to its intrinsic scientific appeal and application-based benefits. From a science perspective, there is a natural desire to know how the brain does something it is good at: recognize faces. Humans are extremely adept at discriminating between faces, and there is evidence for specialized face-processing brain machinery (Kanwisher 2000). Additionally, knowing how the brain recognizes faces provides insight into how the brain generally works. It lays down some of the operations the brain is able and likely to perform. From a clinical perspective, knowing the steps the brain takes to recognize faces provides an opportunity to ask, at which step do things go wrong for people with face processing disorders, such as prosopagnosia and autism? Pinpointing a disorder's defective step illuminates the extent of the disorder, and provides a straightforward test for diagnosis (this step is fine, but the next step is affected). If this test can be done with non-invasive measurement on young children, it will provide an early diagnosis leading to preemptive treatment. From an industry perspective, computerized face identification systems are wanted for airports and casinos to catch unwanted trespassers. Computer scientists have been working diligently to produce such a product, but the current systems perform far worse than normal people (Willing 2003; Zhao et al. 2003). A possible solution is to create a computer system that copies the human brain. Theoretically, a computer using the same steps a brain uses to recognize faces will be just as good as a person. This provides strong motivation for discovering the "neural algorithm" underlying face processing. The M1 70 represents at least one step in the face processing neural mechanism Previous research has uncovered the basic route through the brain subserving face recognition (for a review see Haxby et al. 2002). Major structures have been identified, and their functions have been proposed. However, further refinement of the pathway is needed. Namely, the major structures need to be better characterized, and non-major structures need to be identified. Researchers have established that one of the important brain areas for face recognition, the lateral fusiform gyrus (AKA the fusiform face area, FFA), produces a neural signal called the M170. The M170 is a signal released from the brain about 170 milliseconds after viewing an image, and is measured with magnetoencephalography (MEG). The remainder of this report will focus on what neural step the M170 may reflect. It will include a comprehensive review of past M170 research (preceded by some important facts about MEG), and a new experiment addressing two pivotal questions: 1) Why does the M170 respond to buildings if it is face-selective? 2) Does the M170 reflect categorization (that's a face or not) or identification (that's Jill's face)?<br>by Valerie S. Morash.<br>M.Eng.
10
Lattanzio, Daniele. "Analisi multi-diagnostica dello stato di evoluzione dinamica dell'ammasso globulare M15." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20020/.
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Questo lavoro di tesi si inserisce nel contesto dello studio dell'evoluzione dinamica degli ammassi globulari. Essi sono dei sistemi collisionali, in cui le interazioni gravitazionali tra le stelle comportano continui scambi di energia cinetica tra le componenti di diversa massa. All'interno di questi ambienti molto densi, le frequenti interazioni possono arrivare a modificare profondamente le proprietà strutturali dell'ammasso. Infatti, sebbene gli ammassi globulari della Via Lattea abbiano tutti un’età cronologica molto simile, essi si sono evoluti dal punto di vista dinamico in maniera diversa l’uno dall’altro, in base alle loro dinamica interna, oltre che alle diverse interazioni con la Galassia. Pertanto, gli ammassi globulari rappresentano il laboratorio ideale per studiare i fenomeni di dinamica stellare. Questo lavoro di tesi consiste in uno studio dello stato di evoluzione dinamica dell'ammasso globulare M15, uno dei sistemi più massicci e densi presenti nella Via Lattea. Tale studio è stato effettuato mediante l’utilizzo di tre differenti indicatori di evoluzione dinamica: la distribuzione radiale delle Blue Straggler Stars, la variazione radiale della funzione di massa e la distribuzione radiale della frazione di stelle binarie. Per questo scopo, ci siamo serviti di una combinazione di dati ottenuti con Hubble Space Telescope e telescopi da terra della classe degli 8 m, ottimizzata al fine di campionare l'ammasso in tutta la sua estensione radiale. I risultati ottenuti hanno permesso di classificare, utilizzando questi tre diversi indicatori indipendenti, l’ammasso globulare M15 come un sistema dinamicamente molto evoluto. Prima di questa tesi, l'unico indizio in questo senso era rappresentato dalla forma del profilo di brillanza superficiale, che mostra la deviazione centrale dal modello di King attesa nel caso di un sistema che ha già subito il collasso del nucleo.
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Aponte, Ubillús Juan José. "Potencial antibacteriano de los metabolitos extracelulares producidos por el actinomiceto marino Streptomyces M10-77." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2011. https://hdl.handle.net/20.500.12672/10672.
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Evalúa el potencial antibacteriano de los metabolitos producidos por el actinomiceto marino M10-77. La evaluación preliminar mediante la prueba de “doble capa” mostró gran capacidad inhibitoria de la cepa en estudio, generando halos de inhibición cercanos a 70 mm de diámetro contra patógenos Gram positivos y halos de tamaño reducido contra Gram negativos. Estos datos se vieron reflejados en el ensayo de Concentración Mínima Inhibitoria (CMI) del extracto diclorometánico, donde los resultados más notorios fueron contra una cepa de S. aureus resistente a meticilina, S. saprophyticus 7694 y Streptococcus sp. 7751 (1,9; 1,9 y 0,9 µg/mL, respectivamente) todas de origen clínico. El extracto activo fue fraccionado y parcialmente purificado por cromatografía en columna, obteniéndose cuatro fracciones orgánicas. Estas mostraron poseer actividad antimicrobiana moderada y menor a la del extracto original, hecho que se interpreta como un fenómeno de sinergismo, lo que motivó la realización del bioensayo de sinergismo aplicado a antibióticos. Los resultados mostraron la capacidad sinergística de la fracción II con antibióticos beta lactámicos y aminoglucósidos frente a S. aureus ATCC 43300 (MRSA), potenciando la actividad de la bencilpenicilina, cefotaxima y ceftriaxona hasta por 128 veces, y mejorando la actividad de la estreptomicina y gentamicina hasta por 8 veces. Finalmente, la cepa M10-77 fue clasificada dentro del género Streptomyces en base a características morfológicas y a información brindada sobre su identificación molecular. Se concluye que la cepa Streptomyces M10-77 es una cepa multi-productora de metabolitos antibacterianos de potente actividad y a su vez de metabolitos con capacidad sinergística sobre antibióticos de referencia.<br>Tesis
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Vasconcelos, Luan Tales Costa de Paiva. "Estratégias de indução do antígeno 503 recombinante de Leishmania i. chagasi expresso em Escherichia coli M15." PROGRAMA DE PÓS-GRADUAÇÃO EM ENGENHARIA QUÍMICA, 2018. https://repositorio.ufrn.br/jspui/handle/123456789/25672.
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Previous issue date: 2018-02-23<br>Com cerca de 900.000 a 1,3 milhões de novos casos anualmente, a Leishmaniose
é um complexo de doenças que pode ser fatal se não dada a devida atenção. Apesar de sua
relevância na saúde pública, ainda não existe uma vacina capaz de prevenir a doença em
humanos, e seu tratamento é caro e agressivo à saúde. O presente estudo tem como objetivo
otimizar os parâmetros de indução do antígeno 503 de Leishmania i. chagasi expresso em
Escherichia coli recombinante. Dessa forma, para a indução foi utilizada a lactose nas
concentrações de 0,1; 1,0 e 10 g/L, e o isopropil-β-D-tiogalactopiranosídeo (IPTG) nas
concentrações de 20,0; 100,0; 500,0 e 1000,0 M como moléculas indutoras em diferentes
densidades celulares (densidade óptica a 600 nm de 0,5 e 1,0) de modo a analisar a influência
do instante de indução no rendimento da proteína de interesse. Os resultados mostraram que a
concentração de IPTG de 100,0 M foi a que mais favoreceu a produção do antígeno (0,087
g/L), sendo esta concentração de IPTG 10 vezes menor do que utilizada em trabalhos anteriores
para esse tipo de sistema, e para a lactose foi a de 1,0 g/L (0,016 g/L). Dessa forma, a indução
com 100,0 M de IPTG permitiu obter o antígeno 503 com uma concentração 5,6 vezes maior
que a máxima obtida quando a lactose foi usada como indutor.<br>With nearly 900,000 to 1.3 million new cases annually, Leishmaniosis is a complex of diseases
that can be fatal if not given proper attention. Despite its relevance in the public health system,
there is no vaccine capable of preventing disease in humans so far, and its treatment is expensive
and aggressive to human health. Vaccination remains the most practical and realistic way of
fight against the disease, thus, the production of recombinant antigens as a pathway towards a
vaccine acquisition is necessary. In addition, the optimization of the strategy of the recombinant
antigen’s production is of interest so it can make the process viable. Therefore, the present study
aims to optimize the induction parameters of the 503 Leishmania i. chagasi antigen expressed
in recombinant Escherichia coli. Hence, the induction at different cell densities (optical density
at 600 nm of 0.5 and 1.0) was evaluated in order to analyse the influence of the induction time
on the yield of the protein of interest. In this segment, lactose and isopropyl-β-Dthiogalactopyranoside
(IPTG) were used as inducer molecules, using various concentrations:
0.1 g/L, 1.0 g/L and 10 g/L for lactose and 20 μM, 100 μM, 500 μM and 1000 μM for IPTG.
The results presented that the concentration of IPTG that obtained the higher antigen levels was
that of 100 μM (0.087 g/L), a 10-fold lower concentration than was being previously used in
this type of system, and for lactose it was 1 g/L (0.016 g/L). Thus, the induction with 100 μM
allowed to obtain the antigen with a concentration 5.6 times higher than the lactose induction
maximum concentration.
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Philips, Julian Montagu. "Investigating new models for opera development." Thesis, University of Sussex, 2012. http://sro.sussex.ac.uk/id/eprint/40174/.
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This thesis is a culmination of an AHRC funded collaborative doctoral award between the Centre for Research in Opera and Music Theatre at Sussex University and Glyndebourne Festival Opera. The research took the form of a Composer in Residence scheme in 2006-9 and the submission consists of three new operatic projects, Followers, The Yellow Sofa and Knight Crew. The thesis takes the form of a series of four case studies which explore the creative and aesthetic resonances of the above works in addition to a study of Péter Eötvös's new opera Love and Other Demons, commissioned by Glyndebourne for the 2008 Festival. The exploration of all four case studies is intended to offer a range of possible models for the future development of the operatic art form. The central creative research questions of this project relate broadly to questions of context and the reanimation of tradition. In terms of context, each of these four operatic case studies considers the perspective of the commissioning opera company, of the creative team, of singers and instrumentalists and of audiences. In terms of the reanimation of tradition, this research considers ideas around narrativity in opera and the centrality of the operatic voice and operatic lyricism. The polystylistic nature of opera is just one of several other themes that emerge as a consequence of this research. The thesis lays out each case study in chronological order beginning with an introductory chapter that describes the terms of the residency. Chapter Two considers the site-specific promenade opera Followers, Chapter Three examines the gestation of Péter Eötvös's new opera Love and Other Demons, Chapter Four details the chamber opera The Yellow Sofa developed as part of Glyndebourne's Jerwood Chorus Development Scheme, while Chapter Five projects the central themes of this research onto a larger-scale, grand operatic canvas in a community-specific context. A final Chapter Six concludes with a sketch for a new operatic aesthetic, which attempts to synthesise the creative and research experience of this composer residency.
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Puttick, Keith A. "Welcoming the new arrivals? : a critical analysis of the impact of 'Europe' on the UK's welfare support regime for migrants and their family members." Thesis, Staffordshire University, 2011. http://eprints.staffs.ac.uk/1925/.
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Against a back-drop of changes which since the 1980s have been making the UK’s welfare support regime for migrants progressively more restrictive, the research programme critically analysed the impact of European Law, namely EU Law and the European Convention for the Protection of Human Rights and Fundamental Freedoms (the ECHR), on the regime. The enquiry was undertaken in the research period 2003-2011. After considering historical and theoretical contexts, the factors informing reforms to the regime, and the impact of EU ‘soft measures’ at the start of the research period, the research examined the impact of Convention rights-based interventions following entry into operation of the UK’s Human Rights Act 1998 (from October 2000). It sought to establish whether this could be said to amount to a ‘safety-net’ for claimants without a substantive right to welfare support, in some cases as a result of restrictions linked to immigration status. Consideration was then given to EU Law aspects, including ‘free movement’ rights, and the rights under EU Law of new arrivals from other Member States. This analysed the impact of the UK’s restrictions on support from 1st May 2004 affecting nationals from the A8 and A2 countries coming to the UK: restrictions informed by expectations that claimants should ‘reciprocate’ for their support and ‘contribute’ by taking up employment opportunities and helping to meet the labour market’s needs. Comparisons were made with approaches taken by the two other countries admitting such nations in 2004, Sweden and Ireland. The enquiry then focused on the UK’s scheme of implementation of Directive 2004/38 on the right of citizens of the Union and their family members to move and reside freely in the Member States. Much of the enquiry focused on distinctive features of the scheme such as the operation of the ‘right to reside’, including requirements that claimants must normally be ‘economically active’ or self-sufficient, and the courts’ role in interpreting and applying the scheme, and dealing with challenges based on ‘proportionality’ and discrimination arguments. Collectively, the works informed by the research provide a critical analysis of the UK support regime’s development in the areas referred to. Conclusions are provided in the ‘Research Conclusions’ section of the analysis.
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Ivankovic, Lucy. "A matter of confidence : an exploration of how magistrates' confidence in youth offending team service provision can make a difference to decision-making in the youth courts." Thesis, University of Bedfordshire, 2011. http://hdl.handle.net/10547/220895.
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The vast majority of children and young people appearing in criminal courts in England and Wales are sentenced through a youth court by lay magistrates. The magistrates court deals with 96% of all criminal cases in England and Wales and it is lay magistrates who decide on questions of fact, and sentence those convicted in 91% of these cases. Therefore, how Youth Offending Teams (YOTs) and magistrates work together is a matter of interest. This research explores the extent to which magistrates' confidence in the YOT's service provision can make a difference to the decisions made with regards to bail/remand, sentencing, enforcement and revocation on grounds of good progress. Furthermore, the research considers how YOTs might improve the confidence of magistrates in their service provision and makes recommendations for practice in this regard.
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Mortimore, Judith Ann. "Policy change and the street level policing of children and young people in a Home Counties police force." Thesis, University of Bedfordshire, 2011. http://hdl.handle.net/10547/220933.
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New Labour's youth justice legislation and the "Every Child Matters" programme contained contradictory imperatives. This research examines how Police Officers and Police Community Support Officers (PCSOs) in a community policing setting operationalised those imperatives in order to reach decisions when dealing with children and young people. The review of literature focusses firstly on New Labour policy relating to children and young people, and secondly describes previous research into the practice of policing juveniles, the resilience of police culture and the key factors identified relating to police officer decision making. No recent British research in this area was located. Four overlapping hypotheses were identified, which were: officers will be more responsive to the "Every Child Matters" policy imperatives; officers will be more responsive to the criminal justice imperatives; managerialism will trump both sets of policy imperatives because it is in the officer‟s interests to respond to the demands of management; and both sets of policy imperatives and managerialism notwithstanding, officers will resort to "common sense" responses informed by their own lay criminologies, scales of values, police culture, and police "practice wisdom". These hypotheses were tested using quantitative and qualitative data from 198 self-reporting postal questionnaires and eight follow-up interviews. The research population comprised Police Officers and Police Community Support Officers engaged in Neighbourhood Policing. The research found that the majority of officers operated according to their own lay methodologies (hypothesis four) within the constraints of managerialism (hypothesis three), which led to officers and PCSOs taking actions which they did not always believe to be the most appropriate. Additionally, ambiguities in the legislation and lack of guidance led to the space for the exercise of officer discretion expanding when they were dealing with children and young people, whilst at the same time there was a lack of training on how they should best engage with this age group.
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Serrano, Katharina Anna. "EU-South Pacific : trade-developments nexus in Economic Partnership Agreements." Thesis, University of Central Lancashire, 2009. http://clok.uclan.ac.uk/20210/.
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The purpose of this study was to examine the nature of the trade-development nexus in economic relations between the European Union and Pacific island states. Two interrelated but competing International Relations theories are utilised as tools for analysis: the dependency theory and realist theory. The research consists of analysis of the approaches, assumptions and applicability of both theories in the wider context of North-South relations, with a focus on recent changes in the relationship between the European Union and Pacific island states. The thesis revealed that the lack of success in reaching policy objectives throughout a long-lasting relationship was a key driving force for several policy shifts; these resulted in the implementation of the trade-development nexus into new foreign policy instruments, the Economic Partnership Agreements. Research demonstrated that new dependency theory forecasts more emphasis on the internal development dimension and a development-friendly trade-development nexus. Realist theory however estimates that, depending on power projections and self-interests involved, the trade-development nexus may lead to either more co-operation or more conflict in relations between the European Union and Pacific island states. In order to test the theoretical propositions, the thesis turned to the analysis of two case studies. It looked at the sugar sector in Fiji and the fisheries sector in the South Pacific. Both case studies demonstrated how the trade-development nexus selfadjusts to a given situation or changes through a set of conditions present at any given point in time— a phenomenon that is a defining feature, and possibly the actual essence of the nexus. This flexibility may positively contribute to the European Union's aspirations of becoming an influential global actor through trade and development policies. However, flexibility renders the trade-development nexus unpredictable as policy instrument and therefore less desirable from the perspective of Pacific island countries than it would appear in light of the case-studies.
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Turner, Ian David. "Human rights, positive obligations and the development of a right to security." Thesis, University of Central Lancashire, 2016. http://clok.uclan.ac.uk/16597/.
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In this PhD by Published Work the author is advocating a right to security broadly grounded in ‘communitarian’ ideals. The ‘absolutist’ state theory of, say, Thomas Hobbes, to protect society from collapse, pays too little attention to genuine fears that the state can actually pose a threat to security; in giving the state significant powers of security, it can undermine the very values one is seeking to secure; and is there actual evidence that substantial gains in state power over the last fifteen years or so, since ‘9/11’, for example, have actually made nations more safe? But liberalism, at least the form suggested by, say, Ronald Dworkin, in being unprepared to accept a balance between rights and security, seemingly overlooks threats that undermine the very freedoms liberals like Dworkin wish to protect. And the liberal philosophy, at least its John Locke traditions, of absolute freedoms is too individualistic and attaches too little weight to responsibilities. Plotting a course, therefore, through these criticisms of state absolutism and liberalism one therefore ‘finds’ communitarianism as a philosophy to support a right to security. The author’s ‘communitarian’, right to security is based on an expansive interpretation of ‘positive’ duties of the state, to protect, say, the rights to life of individuals from violations by non-state actors such as suspected terrorists. The author is therefore not proposing an autonomous right to security; he is developing an existing one. And as the author still sees his right to security as largely a justiciable one enforceable before the courts, his approach is a more moderate aspect of communitarianism embracing some liberal ideas of constitutionalism such as judicial review.
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Hussain, Tassadaq. "Muslim women who veil and Article 9 of the European Convention on Human Rights : a socio-legal critique." Thesis, University of Central Lancashire, 2016. http://clok.uclan.ac.uk/16653/.
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Islamic veiling has been the subject of many theological, social and legal debates, which are fluid and their intensity has been further influenced by its contextualised meanings such as religiosity, modesty, identity, resistance, protest, choice and subjugation. Literature on Muslim veiling has either examined its treatment by legal or socio-feminist perspectives, whereas this thesis critiques the religious, socio-feministic and the legal discourses. The contemporary discourse is dominated by competing binaries that label it as a tool of oppression or one of empowerment. Many of the assertions are based not on the veil’s multiple meanings or the wearer’s true motivations but on misplaced assumptions of moral authority by those who oppose or defend the practice, as well as native informants professing to represent veiled Muslim women, leaving Muslim veiled women’s voices muted. Having examined the religious imperative that has a patriarchal basis, the thesis constructs a critique of the two dominant discourses central to the contemporary debates on veiling. One discourse defends the practice as empowering whilst the other calls for prohibitions on the practice using liberation from oppression as a justification, particularly with issues surrounding the wearing of the full face veil. This is followed by a critique of the key cases generated under Article 9 ECHR, which attempts to balance the religious rights of those who veil with the rights of others. The case law highlights that the ECtHR not only falls short in disclosing satisfactorily how it has struck a balance between these competing rights, but also fails to adopt a neutral stance to religious expression through symbols, its reasoning being based on contradictory stereotypes of Muslim women as passive and victims of gender oppression in need of liberation. The influence of such stereotypes and an inadequate application of the margin of appreciation doctrine have led the ECtHR in validating state prohibitions on the hijab and the full face veil, thereby failing to acknowledge the voices of the veiled women at the centre of a human rights claim, delivering a further blow to them. Post the case of S.A.S. v. France the ECtHR has exasperated this even further by allowing an abstract principle of ‘living together’ as a justification for the full face veil’s prohibition in public spaces, resulting in Article 9 rights of Muslim women who veil being endangered even further by the introduction of such an open-ended ground.
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McGarry, John. "Debating the theoretical basis for judicial review : a hermeneutical study." Thesis, University of Central Lancashire, 2008. http://clok.uclan.ac.uk/21908/.
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The purpose of this dissertation is to address the question of how we can constitutionally justify the judicial review jurisdiction of the English courts. Two competing theories are commonly posited as providing this justification: the ultra vires theory and the common law theory. This research consists of a hermeneutical analysis of these two theories; it examines their rationales and the main themes of the debate between their supporters. It also uses immanent critique to reveal a significant lack of 'fit' between judicial review in practice and each of the theories. It is implicit within the two theories that they match the actual exercise of the supervisory jurisdiction. Thus, the lack of fit exposed by the critique brings into question any claims that either theory can provide the constitutional legitimacy for judicial review. The thesis advanced in this dissertation is in two parts. First, it is argued that the doctrine of parliamentary sovereignty operates as a principle. This means that legislation may be balanced against other principles derived from the common law or other statutes. This is in contrast to both the ultra vires and common law theories in which the doctrine is assumed to function as a rule. Second, under this novel conception of parliamentary sovereignty it is not necessary to justify the operation of judicial review by reference to legislative intent or express statutory provision. Rather, the standards of good administration may be rationalized as being developed and applied pursuant to an inherent jurisdiction of the courts.
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Ramnarayan, Venkat Raman [Verfasser], Sebastian [Akademischer Betreuer] Springer, Klaudia [Gutachter] Brix, and Marcus [Gutachter] Gröttrup. "Cytomegalovirus gp40/m152 uses TMED10 as ER anchor to retain MHC class I / Venkat Raman Ramnarayan ; Gutachter: Klaudia Brix, Marcus Gröttrup ; Betreuer: Sebastian Springer." Bremen : IRC-Library, Information Resource Center der Jacobs University Bremen, 2018. http://d-nb.info/1170955878/34.
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Cox, Carol. "Police culture and socialisation within a UK university." Thesis, University of Central Lancashire, 2015. http://clok.uclan.ac.uk/16541/.
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The previous UK Coalition government (2010-2015) made significant efforts to professionalise the police service in England and Wales. One of their approaches was to require police students to study at university, before becoming police officers. It has been hypothesised that requiring police students to study at university may ensure that professionalism develops within these students/officers, with the higher education received. At the same time as developing professionalism within these officers it has been suggested some of the negative aspects of police culture may diminish. Whether or not these hopes are borne out by university training of police students was the central research question for this project. This original research examined socialisation and culture of police students, within a UK university institution. It evolved by utilising reflexive grounded theory to examine the student perception of the police service, using questionnaires, focus groups and content analysis of completed essays, by Foundation in Policing Degree students. In summary the findings of this research suggested that university training of police students may not have the desired effect on professionalism, as police culture appears to develop regardless of the setting. Further to this, minority ethnic students continue to report being less attracted to the police as a career choice. A number of reasons are suggested for these findings and future recommendations are set out. Ultimately, this research concludes that the way a police officer is trained and/or educated requires reviewing, as simply moving the process to a university setting does not automatically deliver the intended outcomes, and in fact can result in the police culture simply flourishing elsewhere.
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Chen, Peng. "Facilitating knowledge sharing in Chalco : the role of communities of practice." Thesis, Northumbria University, 2010. http://nrl.northumbria.ac.uk/3466/.
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Communities of practice (CoPs) have recently become key components in organizational knowledge management initiatives (Wenger, 2004). They have achieved prominence in the context of knowledge management and organizational learning both with scholars and practitioners. Many researches (Ardichvili et al., 2003; Davenport & Voelpel, 2001; Davenport & Probst, 2002) have investigated how some multinational companies integrated different kinds of CoPs into their knowledge management systems. But those studies focus mainly on the regions of the Western countries. There are limited researches conducted on other social context. This research therefore is to address CoPs in a Chinese organization - Chalco and investigates how the Learning Groups as the communities of practice facilitate knowledge sharing in the company. This research adopts the Nonaka‘s (1994) organizational knowledge creation model (SECI) and defines the organizational knowledge sharing as two parts of organization knowledge creation process: socialisation and externalisation. It examines how the Learning Groups facilitate tacit knowledge sharing (socialization) and the knowledge conversion from tacit to explicit (externalization). This research takes the social constructionist standpoint, trying to understand individuals‘ experience of participating Learning Groups in the company, through the interpretive lens. It adopts a qualitative approach using in-depth interviews to gather data which are then analysed using the narrative analysis approach paying attention to individuals‘ experience expressed through their interview accounts. Through narrative analysis, the way in which Learning Groups facilitate tacit knowledge sharing and the conversion from tacit knowledge to explicit knowledge has been emerged. Some influences of Chinese cultural and social factors to the knowledge were also found. The finding of this study suggests that there are some knowledge sharing barriers caused by both organizational factors and cultural factors. The Learning Groups in Chalco have been playing very positive roles in overcoming those barriers and facilitating knowledge sharing in the company. The findings of this research can benefit to both academics and practitioners. It will help the related academics to understand how the Chinese cultural and social influences on knowledge management practice and how CoPs facilitate knowledge sharing in such context. It also provides an example of best practice on knowledge management for other business managers and government policy makers so that they can develop appropriate knowledge management strategies for the benefit of their companies and the social development.
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Deffke, Iris. "Untersuchung von Gesichterpriming und Lokalisation dipolarer Quellorte der Gesichterverarbeitung in Magneto- und Elektroenzephalogramm." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät II, 2006. http://dx.doi.org/10.18452/15539.
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Die Verarbeitung unbekannter und visuell vertrauter Gesichter wurde mittels simultaner Messung von Elektroenzephalogramm (EEG), Magnetoenzephalogramm (MEG) und Verhaltensreaktionen untersucht. Dipollokalisationen zeigten, dass MEG und EEG bei 170 ms und 400 bis 500 ms nach Beginn von Gesichterdarbietungen Aktivierung der posterioren Gyri fusiformes (GF) abbilden. Damit konnten beide Zeitbereiche als Aktivität des fusiformen Gesichterareals interpretiert werden. In einem Primingparadigma wurde bei viermaliger Wiederholung unbekannter Gesichter ein Reaktionszeitpriming gezeigt, das für Wiederholungen mit einem Zeitabstand (Lag) von Sekunden stärker als für mehrere Minuten war. Im EEG bewirkten nur Wiederholungen mit kurzem Lag einen Wiederholungseffekt von 300 ms bis 600 ms an posterioren und zentralen Elektroden. Dieser wurde als Korrelat impliziter Gedächtnisverarbeitung von Gesichtern im GF interpretiert. Ein frontaler Wiederholungseffekt ab 700 ms wurde als Ausdruck inzidentellen Erkennens der Gesichterwiederholungen angesehen. Das MEG zeigte posterior einen Wiederholungseffekt ab 800 ms für das kurze Lag. Für das lange Lag wurden keine MEG- oder EEG-Effekte gefunden. Die Wiederholung des Primingexperimentes mit den in einem Lerntraining vertraut gewordenen Gesichtern erzeugte eine generelle Verkürzung der Reaktionszeiten, aber eine Abschwächung des Primingeffektes für das kurze Lag und einen Verlust der Abhängigkeit der Primingstärke vom Zeitabstand. Diese Veränderungen gingen im EEG mit dem Trend zur Verstärkung des posterioren Wiederholungseffektes ab 500 ms einher. Im MEG konnte für die vertrauten Gesichter ein dem EEG in Zeit und Entstehungsort analoger Wiederholungseffekt gezeigt werden. Die Ergebnisse der Untersuchung von Priming bringen Evidenz für die Existenz von Primingeffekten für unbekannte Gesichter. Sie zeigen die Abhängigkeit der Primingeffekte vom Wiederholungsabstand und die Veränderung von Primingeffekten beim Erwerb visueller Vertrautheit.<br>The processing of unfamiliar and visually familiar faces was examined in a simultaneous measurement of Electroencephalogram (EEG), Magnetoencephalogram (MEG) and behavioural reactions during the presentation of a priming task. Dipole modelling on the EEG and MEG data localized activity in posterior fusiform gyri around 170 ms and between 400 and 500 ms post stimulus onset. Both time ranges were interpreted as activity correlates of the fusiform face area. In the priming paradigm unfamiliar faces were repeated four times. A reaction time priming effect could be shown. This effect was stronger for a short lag (seconds) between repetitions than for minutes. In EEG, only repetitions with short lag evoked a repetition effect at posterior and central electrodes between 300 and 600 ms. This effect was interpreted as a correlate of implicit memory processes presumably generated in the fusiform gyrus. A frontal repetition effect starting around 700 ms was considered a reflection of the incidental recognition of the face repetitions. The MEG data showed a repetition effect for the short lag starting at 800 ms. No electrophysiological effects of face repetition were found for the long lag. Some months later, the same subjects were visually familiarized with the faces in three learning sessions and the priming experiment was repeated. An overall shortening of reaction times was found together with a weakening of the priming effect for the short lag and an absence of the lag’s influence on the strength of the priming effects. In the EEG data a trend for a strengthening of the posterior repetition effect from 500 ms onward emerged. The MEG data yielded a repetition effect for the familiar faces that was analogous to the EEG effect. The results of the priming task give evidence for the existence of priming effects for unfamiliar and familiar faces. They furthermore demonstrate the dependency of priming effects on the lag between repetitions and the visual familiarity of the faces.
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Hatak, Isabella, Arne Floh, and Alexander Zauner. "Working on a dream: sustainable organisational change in SMEs using the example of the Austrian wine industry." Springer, 2014. http://dx.doi.org/10.1007/s11846-014-0157-1.
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Driving sustainable development through new products, services, techniques and organisational modes that substantially reduce environmental impacts, or ecopreneurship, is especially important for small and medium-sized enterprises (SMEs) as they have a vital role to play in managing limited environmental and social resources. Reaping the benefits associated with ecopreneurship, however, requires a fundamental qualitative change process at the firm level. However, there remains
considerable uncertainty as to how ecopreneurs will discover, develop and realise sustainabilityrelated
opportunities in their organisations. Thus, the purpose of this article is to address this gap by analysing how this qualitative change process associated with a shift to sustainable development actually unfolds in SMEs. To do so it examines small and medium-sized wineries in Austria. Based on the results of a Delphi study, a multi-layer process model that differentiates between unfreezing,
changing and refreezing processes is developed. The framework shows that the unfreezing of the status quo is mainly accomplished by the business owner's attitude towards sustainability. In the course of the changing process, change related to the adoption of greener business practices follows a hierarchical order, starting with business activity (the first layer). Then, four dimensions of capital resources (the second layer) must be revised in order to implement the change successfully. After that,
relevant stakeholders (the third layer) must be integrated into this iterative learning process. Finally, in the course of refreezing, change is embedded in the organisation by the ongoing commitment of the business owner and future sustainable expansion strategies. The developed framework may serve as a guideline for small and medium-sized wineries, but also for a broader set of SMEs implementing sustainable organisational change in the future. The framework could also be used by national governments or certification authorities uncertain of how best to support the change process in SMEs. (authors' abstract)
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Qouteshat, Omar Husain jamil. "The enforcement of electronic arbitral awards in international commercial disputes under the New York Convention : the case of Dubai and DIFC courts." Thesis, University of Central Lancashire, 2017. http://clok.uclan.ac.uk/20465/.
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When arbitration is conducted online, some inherent, fundamental issues arise which could potentially undermine the enforceability of the final award under the provisions of the United Nations Convention on the Recognition and Enforcement of Foreign Arbitral Awards of 1958, the “New York Convention” (NYC). The study identifies four key challenges which a winning party seeking the enforcement of an electronic award according to the NYC might face with relation to the enforcement of that award: the validity of electronic arbitration agreements, the enforceability of consumer arbitration agreements concluded online, obstacles arising out of the conduct of the arbitration procedures online and the issue of electronic authentication of the final award. The study first critically analyses the NYC, to identify some key problems in relation to each of the said issues which might compromise or undermine the enforcement of awards rendered in online arbitration; it then makes suggestions as to some possible amendments to the NYC. The study then goes on to consider these issues in the context of the applicable law before the Dubai and DIFC Courts as the enforcement courts, to examine their ability to enforce such an award. The study concludes with several recommendations for both practice and law reform in the jurisdictions discussed, in relation to each issue. The study is original in that it is the first comprehensive analysis of all the said issues, from formation of the arbitration agreement, through various stages of online procedures, to the final enforcement of the award, within the examined jurisdictions. Further, the recommended changes would help to improve the efficiency and reliability of the courts of Dubai and DIFC with regard to the enforceability of an award given via online arbitration. This is a particularly important issue in light of the current and anticipated growth in the prominence of the identified jurisdictions as financial and business centres, the centrality of international arbitration to international business and the fundamental need for confidence in the enforceability of the courts and arbitration awards.
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Christofi, Despina. "Effective judicial protection of bank depositors during the financial crisis and arbitration in an EU context." Thesis, University of Central Lancashire, 2018. http://clok.uclan.ac.uk/24012/.
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It is generally assumed that the EU law regime excludes arbitration from its scope, since issues of EU law must be resolved within the EU legal order, according to the wording of the Treaties and the case law of the CJEU. It is also assumed that courts offer adequate and effective protection to litigants, thus arbitration does not make any further contribution to parties. This thesis challenges these ontological assumptions, using the case of bank depositors, and aims to investigate whether courts within the EU protect bank depositors effectively or whether arbitration would offer further protection. For this purpose, the nature of bank deposits is considered, and the approach of courts and arbitrators towards depositors are comparatively analysed, based on effectiveness of protection, as the appropriate tool of assessment. The findings of this examination lead to the final research question regarding the role, if any, of arbitration within the EU legal order and the relationship between arbitration and litigation, in particular within the context of the global financial crisis. Thus, the central argument of this thesis is that, if it is accepted that arbitration does have a place in the EU legal order, and based on the argument that bank deposits qualify as investment, bank depositors can enjoy the protection offered by international investment arbitration, which can protect them more effectively than litigation The originality of this work centers around three points. Firstly, this thesis aims to use the principle of effectiveness in a substantial sense rather than its procedural meaning, considering whether individuals do not only access the justice, but also being remedied effectively. Secondly, this thesis argues that bank deposits can be treated as investment, thus depositors could enjoy further protection offered by investment law. Finally, the thesis supports that the EU law regime does have some place available for arbitration, albeit its traditional exclusion, especially during the particular period of the financial crisis.
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Flach, Britta. "Untersuchungen zur Rolle der M10 Region des murinen Gammaherpesvirus 68 (MHV-68) in vitro und in vivo durch mit der BAC-Technologie generierte rekombinante Viren." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-102926.
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Oliveira, Filho Marcos Antonio. "Recuperação e purificação parcial do antígeno 503 de Leishmania i. chagasi em E. coli M15 recombinante e remoção simultânea de lipopolissacarídeos em sistemas aquosos bifásicos." PROGRAMA DE PÓS-GRADUAÇÃO EM ENGENHARIA QUÍMICA, 2018. https://repositorio.ufrn.br/jspui/handle/123456789/25111.
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Previous issue date: 2018-02-21<br>Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)<br>O antígeno 503, uma proteína encontrada na forma amastigota de Leishmania i. chagasi, possui potencial para utilização em vacinas e testes para diagnóstico específico da leishmaniose visceral. No entanto, um problema intrínseco à purificação de proteínas expressas em E. coli é a presença de endotoxinas (LPS), componente da parede celular de bactérias gram-negativas, que provoca resposta imune quando em contato com células de defesa humana. Os sistemas aquosos bifásicos (SABs) vêm sendo utilizados na purificação de biomoléculas por apresentar vantagens como eliminar a etapa de clarificação, concentrar e purificar a molécula alvo e, no presente estudo, efetuar a remoção parcial do LPS, durante o protocolo de purificação. Assim, o objetivo deste trabalho foi avaliar os SABs baseados em polietilenoglicol (PEG 1500) e etanol com sais (fosfato de potássio dibásico (K2HPO4) e sulfato de amônio ((NH4)2SO4)) e acetonitrila com glicose na recuperação e purificação parcial do antígeno 503 de Leishmania i. chagasi expresso em E. coli M15 com remoção simultânea de LPS. Inicialmente, foram obtidas as curvas binodais, pelo método de titulação por ponto de nuvem a temperatura ambiente (25 ± 2 ºC) a fim de determinar as concentrações de trabalho dos componentes dos sistemas avaliados. Esses dados experimentais também foram usados para os cálculos dos parâmetros da equação proposta por Merchuk, e obtenção do comprimento das linhas de amarração – tie lines length (TTL). Definindo-se a composição dos sistemas, aplicou-se 20% de homogeneizado celular de E. coli nos SABs, observou-se que o sistema que mais favoreceu a recuperação e concentração do antígeno 503 foi o constituído por PEG 1500 e K2HPO4, atingindo um fator de purificação de 1,55 e percentual de recuperação de 116,96% na fase de topo, nas condições de 30% de PEG 1500 e 10% de sal (m/m). A remoção de LPS foi promissora para todos os sistemas avaliados, se mantendo acima de 90,0%. O ensaio que apresentou melhor purificação também se destacou na remoção desse contaminante, atingindo 99,90% de LPS removido. Deste modo, os SABs podem ser empregados como etapa precedente à cromatografia para remoção de elevadas concentrações de LPS e aumentar o grau de pureza de proteínas recombinantes expressas em E. coli.<br>The antigen 503, a protein found in the amastigote phase of Leishmania i. chagasi, can integrate vaccines and specific diagnosis assays for visceral leishmaniasis (VL). However, a problem on the purification of proteins expressed in E. coli is the presence of endotoxins (LPS), natural compound of gram-negative bacterial expression systems, which triggers immune response in human body and interacts with the proteins impairing possible chromatography steps. To solve this problem, Aqueous Two-phase Systems (ATPS) can be employed with the advantages of eliminate clarification steps on the whole process, indeed it also concentrates the molecule of interest and reduces the concentration of LPS, preparing the product for a more efficient adsorption in the following steps. Thus, the present work aimed evaluate ATPS based on Polyethylene glycol (PEG 1500) /Salt, Ethanol/Salt (K2HPO4 and (NH4)2SO4) and Acetonitrile/Dextrose on the partial purification of antigen 503 expressed in recombinant E. coli M15 and simultaneous removal of LPS. For that, firstly, binodal curves of these systems were constructed by cloud point titration method at room temperature (25 ± 2 ºC) in order to determine the concentrations of each evaluated system. The parameters of the equation purposed by Merchuk were calculated by these experimental data and the Tie-Line Lengths (TLL) were obtained. When 20% of cell homogenate from E. coli was applied, the system which exhibited the best results was 30% PEG 1500 and 10% K2HPO4 (m/m) achieving 116,96% of recuperation and 1,55 of purification factor (assay P3). The removal of endotoxins was promising for all the systems evaluated, as it was kept above 90,0%. The assay P3 also stood out for the LPS removal, being able to remove 99,90%. Thus, ATPS can be a precedent step to the chromatography for the removal of high LPS concentration and grow the purity of recombinant proteins from E. coli.
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Mühlbacher, Jürgen, and Tom Siebenaler. "Ready For Changes? The Influence of General Self-efficacy and Resistance to Change on Managers' Future Competence Requirements." Mendel University Brno, Faculty of Business and Economics, 2018. http://epub.wu.ac.at/6766/1/131%2DProof%2D707%2D2%2D10%2D20190103.pdf.
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With this study, we will test the interrelations between the psychological concept of self-efficacy
of managers and its influences on the resistance to change. The results show that it makes a
qualitative difference, if change in competences occurs in a positive or a negative direction and
that there is a clear predisposition of managers concerning change. Both results have to be taken
into account in designing changes processes.
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Vaz, Michelle Rossana Ferreira. "Influ?ncia das condi??es de cultivo na produ??o de ant?genos recombinantes de Leishmania i. chagasi utilizando Escherichia coli M15 cultivada em incubador rotativo e biorreator." Universidade Federal do Rio Grande do Norte, 2011. http://repositorio.ufrn.br:8080/jspui/handle/123456789/15912.
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Previous issue date: 2011-12-29<br>Conselho Nacional de Desenvolvimento Cient?fico e Tecnol?gico<br>Escherichia coli has been one of the most widely used hosts in recombinant protein production, in both laboratory and industrial scale since the advent of recombinant DNA technology. Despite the substantial progress of studies on the molecular biology and immunology of infections, there is currently no medication-based prophylaxis capable of preventing leishmaniasis. As such, there is a great need to identify specific antigens for the development of vaccines and diagnostic kits against visceral leishmaniasis. Thus, the primary goal of the present study is to assess the influence of cultivation conditions on the production of Leishmania chagasi antigens, carried out in a rotating incubator and bioreactor. To that end, several assays were conducted to evaluate the kinetic behavior of antigens (648, 503) of Leishmania. i. chagasi in two different compositions of media (2xTY, TB), with and without an inducer. In order to improve expression, assays were performed in a benchtop bioreactor using the best conditions obtained in a rotating incubator, in addition to assessing the influence of stirring speed. Results show that high complexity of the cultivation medium favored kinetic growth of clones (648, 503). However, in assays submitted to induction by IPTG, this elevated complexity did not promote the expression of recombinant proteins. Expression of antigens 648 and 503 exhibited behavior associated with growth and, in terms of location, proteins 648 and 503 are intracellularly stored. Lactose may be the most adequate inducer in protein expression, when considering factors, cost, toxicity and stability. Elevated stirring may increase cell growth in clone 53, although it may not result in high concentrations for the protein of interest. On the other hand, positive results were obtained for all recombinant clones (648, 503) tested, confirmed by the electrophoretic profile<br>A Escherichia coli ? um dos hospedeiros mais utilizados para produ??o de prote?nas recombinantes tanto em escala de laborat?rio como em escala industrial desde o advento da tecnologia do DNA recombinante. Apesar do avan?o expressivo dos estudos da biologia molecular e da imunologia das infec??es, n?o existe, atualmente, nenhuma droga profil?tica capaz de prevenir o calazar. Desta forma, existe uma grande necessidade de identifica??o de ant?genos espec?ficos para o desenvolvimento de vacinas e kits para diagn?sticos contra a Leishmaniose visceral. Com base no exposto, o presente trabalho tem como foco principal avaliar a influ?ncia das condi??es de cultivo na produ??o dos ant?genos de Leishmania i. chagasi em cultivos realizados em incubador rotativo e biorreator. Para atingir o objetivo proposto, v?rios ensaios foram realizados a fim de se avaliar o comportamento cin?tico dos clones (648, 503) de Leishmania i. chagasi em duas diferentes composi??es de meio (2xTY, TB), com e sem adi??o de indutor em incubador rotativo. Para melhorar a express?o, ensaios foram conduzidos em biorreator de bancada com as melhores condi??es obtidas em incubador rotativo, al?m da avalia??o da influ?ncia da velocidade de agita??o. Com base nos resultados obtidos, pode-se observar que a elevada complexidade do meio de cultivo favoreceu a cin?tica de crescimento dos clones (648, 503), no entanto, ao se tratar dos ensaios submetidos ao procedimento de indu??o por IPTG, a elevada complexidade do meio de cultivo n?o favoreceu a express?o das prote?nas recombinantes. Pode-se observar que a express?o dos ant?genos 648 e 503 apresentam um comportamento associado ao crescimento e que em termos de localiza??o, as prote?nas 648 e 503, s?o armazenadas intracelularmente. A lactose pode ser o indutor mais adequado na express?o das prote?nas tendo em vista os fatores, custo, toxicidade e estabilidade. A elevada agita??o pode aumentar o crescimento celular do clone 503, entretanto, pode n?o acarretar em altas concentra??es da prote?na de interesse. Por outro lado, foram obtidos resultados positivos para todos os clones recombinantes (648, 503) testados, confirmada atrav?s do perfil eletrofor?tico
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Ribeiro, Vitor Troccoli. "Avaliação da estabilidade do plasmídeo pQE-30 e expressão do antígeno 503 de Leishmania i. chagasi em Escherichia coli M15 em diferentes concentrações de IPTG e temperaturas de cultivo." PROGRAMA DE PÓS-GRADUAÇÃO EM ENGENHARIA QUÍMICA, 2018. https://repositorio.ufrn.br/jspui/handle/123456789/25113.
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Previous issue date: 2018-02-23<br>A leishmaniose visceral é uma doença infecto-parasitária causada por protozoários do gênero Leishmania, podendo ser letal quando não há tratamento adequado. Estima-se que existem 12 milhões de pessoas infectadas pela doença, mas infelizmente não há nenhuma vacina capaz de prevenir a doença. Ademais, o tratamento da doença apresenta alto custo e elevada toxicidade. Diante disso, deve-se destacar a pesquisa de componentes antigênicos purificados que possam ser utilizados como ferramenta para obtenção de vacinas ou testes para diagnóstico específico. Neste contexto, o presente trabalho tem como objetivo avaliar a influência da concentração de IPTG durante a indução e a influência da temperatura de cultivo na expressão do antígeno 503 e na estabilidade do plasmídeo pQE-30 em Escherichia coli. Todos os ensaios foram realizados em incubador rotativo e feitos em duplicata. Primeiramente foram realizados cultivos induzidos com IPTG nas concentrações de: 0,01 mM; 0,1 mM; 0,5 mM; 1,0 mM e 1,5 mM na temperatura de 37 °C. A concentração de indutor não afetou a estabilidade do plasmídeo e quando induzido com 1,0 mM, a expressão de antígeno 503 máxima foi de 0,101 ± 0,004 g/L. Foi possível verificar que a menor concentração de IPTG utilizada foi o suficiente para conseguir a expressão da proteína recombinante. Em seguida, a concentração de IPTG foi fixada em 1,0 mM e avaliadas as temperaturas de cultivo de 27, 32 e 42 °C. Estes ensaios foram comparados com o ensaio realizado anterior a 37 °C. A temperatura influenciou a estabilidade do plasmídeo, sendo que quanto menor a temperatura de cultivo, maior estabilidade. De acordo com os resultados, foi possível verificar que a temperatura de 37 °C obteve maior expressão do antígeno 503, sendo considerada portanto, as condições ótimas para produção de antígeno 503 em incubador rotativo.<br>Visceral leishmaniasis is an infectious-parasitic disease caused by protozoa of the genus Leishmania, which can be lethal when there is no adequate treatment. It is estimated that there are 12 million people infected by the disease, but unfortunately there is no vaccine capable of preventing the disease. In addition, the treatment of the disease presents high cost and high toxicity. Therefore, we must highlight the research of purified antigenic components that can be used as a tool to obtain vaccines or tests for specific diagnosis. In this context, the present work aims to evaluate the influence of the concentration of IPTG during the induction and the influence of culture temperature on 503 antigen expression and on the stability of plasmid pQE-30 in Escherichia coli. All assays were performed in a rotary incubator and made in duplicate. First, IPTG induced cultures were carried out at concentrations of: 0.01 mM; 0.1 mM; 0.5 mM; 1.0 mM and 1.5 mM at 37 °C. The concentration of the inducer did not affect the stability of the plasmid and when induced with 1.0 mM, the 503 antigen expression was maximal 0.101 ± 0.004 g / L. It was possible to verify that the lowest concentration of IPTG used was enough to achieve expression of the recombinant protein. Thereafter, the concentration of IPTG was fixed at 1.0 mM and the cultivation temperatures of 27, 32 and 42 °C were evaluated. These assays were compared with the previous assay performed at 37 °C. Temperature influenced the stability of the plasmid, and the lower the culture temperature, the greater the stability. According to the results, the temperature of 37 °C obtained the highest expression of 503 antigen, being considered therefore, the optimal conditions for 503 antigen production in a rotary incubator.
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Al, Kiyumi Fawzi Mubarak. "Unfair dismissal study in Omani labour law with emphasis on the relevance of Shari’a." Thesis, University of Bedfordshire, 2013. http://hdl.handle.net/10547/293775.
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The aim of this research is to investigate the implications of unfair dismissal within the boundaries of Omani labour law with particular relevance to the role of Shari’a. Shari’a itself does not provide a legal code, contract law, or a law of tort as yet but it does provide examples of applicable rules, supported with analogies, to deal with employment. The basic principles of forming a contract in Omani Commercial Law; English Law and Shari’a are similar; however, they differ in application. Likewise, the principles of the employment contract are similar with a few differences being seen in implementation; specifically with regards to unfair dismissal issues. This research used a qualitative approach that has enabled the generation and analysis of data from multiple sources including literature review, semi-structured interviews, court cases, Shari’a implied employment contract principles as found in the Qur’an, the Sunnah and relevant Islamic texts. The research shows that the main reasons for employee dismissal can be categorised into: poor performance, disobedience regarding the contractual rules and regulations, absenteeism, aggressive behaviour and an extreme critical attitude in the work-place. From the employee’s perspective, the main reasons for filing cases at Oman Courts were to seek justice, to obtain fair compensation or to highlight the moral values that form the Islamic code of practice. In contrast the employers considered seeking financial gain and revenge as the motivating factors for employees for filing court cases. There obviously is a mismatch to the reasons by each side and the key findings from this research suggest that there is a modest impact of the legal aspects of Shari’a on the Omani Law of Contract and the Employment Law though it is normally conceived by the public that Shari’a is the fundamental law that governs all aspects of muslim life. There needs to be an overwhelming expectation and requirement to develop procedures in the Omani Employment Law that expedite the process of dealing with dismissal cases and the propositions of establishing an arbitration committee may seem to be a way forward. In addition, the establishment of a Labour Court is paramount as at present the employment cases are heard in the Commercial Courts. This will align with the approach taken in the English system where the Employment Tribunals and the Employment Appeal Tribunal oversee cases and minimize delays in achieving justice. There is also a strong argument that there needs to be a review of Article 40/35/2003 that deals with employer rights to dismiss the worker without prior notice in order to establish a solid foundation for justice in the Sultanate of Oman. Unfair dismissal is a phenomenon that impacts on the employee, the employer, the employee’s wider family network and society. This study provides an in-depth understanding and insight into these impacts and into the capacity of Shari’a impact to address modern employment issues in relation to the labour laws and secular laws being used in Oman today.
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Barnabas, Sylvanus. "The role of international law in determining land rights of indigenous peoples : the case study of Abuja Nigeria and a comparative analysis with Kenya." Thesis, Northumbria University, 2017. http://nrl.northumbria.ac.uk/32544/.
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In 1976, the Nigerian Government compulsorily acquired the ancestral lands of Abuja peoples of Nigeria without payment of compensation or resettlement. This is legitimised under Nigerian State laws. Indigenous peoples (IPs) suffer from injustices in relation to land globally. The purpose of this thesis is to find answers to the research questions emanating from this case study. One avenue explored herein in addressing dispossession of IPs’ lands in Africa, is through considering the relevance of international law on their rights. However, there is no universally agreed definition of IPs. In the determination of whether international law provides solutions to the challenges of protecting land rights of Abuja peoples, the existing description of IPs is challenged. The second avenue explored herein, is through a comparative approach to understanding how Kenya has resolved these challenges and how Nigeria should respond to similar challenges. The case study is used to illustrate the need for a viable relationship between State law, IPs’ customary law and international law. The choice of Nigeria is because the case study is in Nigeria. The choice of Kenya as a comparator is because like Nigeria, Kenya is Anglophone with a plural legal system and has recently embarked on law reforms in relation to customary land rights and the place of international law within its legal system. Drawing from theories of legal pluralism and post-colonialism, this doctrinal, case study and comparative enquiry, makes the following original contributions to knowledge. Firstly, the case study is used to argue that international law should expand its description of IPs to include collective of peoples with different cultures. Secondly, it draws from international child rights law to advance the argument that international law on IPs should present them more positively. Finally, the comparative analysis between Nigeria and Kenya on the above subjects has not been made by any known literature at the time of writing.
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Carlin, Lindsey Elizabeth. "Natural killer cell activation, trafficking, and contribution to immune responses to viral pathogens." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/1302.
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Natural killer (NK) cells are a critical component of the immune response against viral infections. NK cell depletion prior to murine cytomegalovirus (MCMV) infections results in increased susceptibility to infection in several mouse strains. The mechanism of protection in C57Bl/6 mice is dependent on the activation of NK cells by Ly49H recognition of m157. Our previous studies have examined important residues of m157 for Ly49H recognition, as well as the contribution of m157 glycosylation to NK cell activation. However, what role the glycophosphatidyl inositol (GPI) anchor of m157 plays in Ly49H activation was unknown. Here we demonstrate that the GPI anchor of m157 regulates the surface expression of the protein. While the GPI anchor was not required for recognition of m157 by the activating or inhibitory Ly49 receptors, expression of GPI-anchored m157 resulted in greater receptor downregulation on NK cells, as well as increased NK cell cytotoxicity compared to transmembrane m157.
In addition to MCMV infections, NK cells have been shown to participate in the immune response to influenza A virus (IAV). However the exact role of NK cells in IAV infection is less clear, as some studies have found NK cells to be protective, while others have shown that NK cells cause lethal immunopathology. It is likely that the severity of IAV infection may dictate the NK cell response to IAV infection (i.e. protective vs. immunopathogenic). Herein we show that NK cell accumulation in IAV-infected lungs and lung-draining lymph nodes (DLN) is regulated by the severity of IAV infection, where there is increased NK cell accumulation in the lungs during high dose IAV infection, and greater NK cell accumulation in the DLN in low dose IAV infections. Despite significant NK cell recruitment to the lung during IAV infection, as well as previously published studies demonstrating the importance of NK cells to IAV immunity, NK cell depletion prior to IAV infection did not result in a significant change in morbidity or mortality. Interestingly, NK cell depletion resulted in a significantly greater number of CD4 T cells in the IAV infected lung. Further, both CD4 and CD8 T cells in NK-depleted mice showed increased IFN-Γ production. Finally, while not statistically significant, NK cell depletion resulted in a trend toward greater protection from heterosubtypic IAV challenge infections. Taken together these results suggest that NK cells may either regulate the adaptive immune response to IAV infection through suppression of CD4 and CD8 T cells, or that the T cell response to IAV infection is able to compensate for the loss of NK cells. Moreover, while NK cell suppression of T cell function during a primary IAV infection does not result in increased susceptibility to primary IAV infections, NK cell regulation of adaptive immune responses may suppress the memory T cell response, and therefore leave the host more susceptible to secondary infections.
Overall the studies presented herein demonstrate a complex role for NK cells in the immune response against viral infections. Ly49H+ NK cells directly kill MCMV-infected cells and m157-bearing targets, but NK cell activation is regulated by ligand density, as well as the ligand membrane anchor. Additionally, NK cells suppress adaptive immune responses during a primary IAV infection, resulting in changes to the T cell response during both primary and memory responses.
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Macias, Pilar. "La temporalité de l'art photographique." Master's thesis, Université Laval, 2004. http://hdl.handle.net/20.500.11794/34279.
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En vivant hors de mon pays d'origine, certains aspects de la vie quotidienne deviennent plus importants que d’autres, car !'éloignement de ma culture mexicaine a transformé ma manière de travailler, de réfléchir et de réaliser ma propre œuvre qui est le reflet de l’essence de mon être. Ce projet se veut un lien entre mon passé révolu et mon présent qui rapidement devient passé et se transforme en souvenir. Le passé est symbolisé par des petits éléments qui proviennent de ma culture d’origine et mon présent, par des paysages environnant mon milieu de vie. Dans les deux cas, je suis là, comme un personnage en mouvement et mes pieds sont la preuve de mon existence. J’ai choisi de travailler avec la photographie et la vidéo car ils laissent des traces de ce temps qui s’écoule. La succession d’instants se confond entre mes souvenirs et mes réalités, créant un mouvement constant qui influence mon identité. Je suis ce que j’étais et aussi ce que je vis à l'instant présent. Dans ce processus, l’espace où je me suis trouvée a aussi été un facteur de changements. Ce projet est composé de deux séries de photographies et d’une œuvre vidéo. Ces trois éléments forment un tout et se complètent, afin de démontrer cette transformation identitaire que j'ai vécue et qui fait déjà partie de mon passé.<br>Québec Université Laval, Bibliothèque 2019
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Jung, Yong-Chul. "Bacillus thuringiensis strain M15, a novel autoagglutinable, non-serotypeable strain-cloning and characterization of a novel cry31A-type crystal protein gene, cry31Aa2, and two new insertion sequences, IS231M and -N." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2002. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/NQ65709.pdf.
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Lis, Natalia [Verfasser], Sebastian [Akademischer Betreuer] Springer, Sebastian [Gutachter] Springer, Susanne [Gutachter] Illenberger, and Wolfram [Gutachter] Brune. "The murine cytomegalovirus immunoevasin gp40/m152 inhibits activation of NK cell receptor NKG2D by intracellular retention and cell surface masking of RAE-1 gamma ligand / Natalia Lis ; Gutachter: Sebastian Springer, Susanne Illenberger, Wolfram Brune ; Betreuer: Sebastian Springer." Bremen : IRC-Library, Information Resource Center der Jacobs University Bremen, 2020. http://d-nb.info/1222738899/34.
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Abdullah, Muhammad Tahir. "Role of UAE courts in international commercial arbitration." Thesis, University of Bedfordshire, 2013. http://hdl.handle.net/10547/305727.
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Concept of arbitration has been prevalent, historically, in the Middle East since the early days of Islam. The arbitral process has been problematic in the UAE however, it has not been until recently that the UAE has recognized the importance of arbitration as a powerful dispute resolution alternative and revised its legislation to accommodate the proceedings of domestic and international arbitration. In the past, foreign investors have been reluctant to select the UAE seat for their arbitration proceedings. There has been a perception that, as a general rule, the practice of international commercial arbitration in the Middle East is still in its infancy. The UAE is now demonstrating to the international community that it has the necessary infrastructure and laws in place to successfully count itself as one of the key arbitration players, alongside London, Paris and Hong Kong. This has been the result of the UAE updating their laws, reforming dispute resolution practice and procedures and through the establishment of key regional arbitration centres. The UAE's accession to the New York Convention was also seen as a significant step in demonstrating the UAE's commitment to foreign investors and the international community. Under Federal Decree No. 43 of 2006, the UAE managed to accede to the New York Convention. The UAE's accession is considered as a mile stone towards provision for a more straightforward arbitral process and enforcement of foreign arbitral awards in other Convention states. As a recent development, the UAE has evidenced the joint venture between the Dubai International Financial Centre ('the DIFC') and the London Court of International Arbitration ('the LCIA'), in February 2009, to create the DIFC-LCIA Arbitration Centre ('the DIFC~LCIA'). The DIFC-LCIA operates alongside the longer-established Dubai International Arbitration Centre ('the DlAC'). Both offer their own procedural rules and regulations for the amicable settlement of disputes through arbitration. The Courts role is vital in an arbitral proceeding in any jurisdiction. Although arbitration is believed as a court-free, independent forum for dispute resolution; the court plays fundamental role to ensure that the arbitral proceeding is taking place in a moderate and independent decorum. The UAE Court's role towards the International commercial arbitration has been very problematic and the courts historically used to intervene in the arbitral proceeding over tiny issues. The new UAE arbitration laws has changed the situation and curtailed the courts powers to interfere the arbitral proceeding. At present, the arbitration in the UAE is more independent and straightforward. The proposed UAE arbitration law has much more similarities with the Model Law UNCITRAL and meets the International standards. A lot of work still has to be done in order to make the arbitration more independent, straightforward and friendly in the UAB. The Court's role is vital and is required to be more supportive then it is at present in the arbitral process.
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Macias-Valadez, Daniel. "Improvement of vertical precision in GPS positioning with a GPS-over-fiber configuration and real-time relative hardware delay monitoring." Thesis, Université Laval, 2011. http://www.theses.ulaval.ca/2011/28039/28039.pdf.
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Farran, Sue. "Vanuatu : lands in a sea of islands." Thesis, Northumbria University, 2013. http://nrl.northumbria.ac.uk/15613/.
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This collection of eight single-authored papers published between 2008 and 2012, provides detailed and critical insight into land issues in the Pacific island country of the Republic of Vanuatu. Developed largely from conference papers delivered to international audiences, these publications make a novel and significant contribution to the prior knowledge base in a number of ways. Firstly, the research behind these papers has combined physical proximity to the subject matter – through being based in Vanuatu for several years, with access to a range of legal and other materials as well as personal insights, with a broader intellectual expertise in the law of property and trusts as introduced into the region. A combination of doctrinal and empirical research has made it possible to give a specifically focussed law in context and law in practice perspective, while not losing sight of the inter-relationship of law and society. In this way the existing knowledge base founded on anthropological and ethnological studies has been given a further and contemporary, legal dimension. Secondly, the desire to reach a wider audience than the regional or local, has meant that these publications have engaged Vanuatu as a case-study with broader themes, sometimes starting from the local and exploring outwards and sometimes starting from the global and narrowing in on Vanuatu as a concluding focus. While recognising all that makes Vanuatu unique, the contribution that this collection makes is to bring this island study from the particular to the general, in from the margins or as part of a removed and rather isolated area of study, towards the mainstream. Thirdly, these publications articulate land developments at a crucial moment. The first decade of the twenty-first century, has been a time of increased public awareness of land issues in Vanuatu and in the Pacific region more generally, and a time of increased donor intervention in land and law related activities. That this research and the related research that informs it, is integral to this process has been evidenced by cross referencing to some of the work and other indicators of esteem by aid donors, inter-state agencies and other academics. Land remains a site of contestation in Vanuatu. The critical analysis of present issues, against the historical context of colonial rule and its subsequent influence; the introduction of foreign laws and institutions and the continuing importance of unwritten customary law, exposes many of the challenges that are encountered in trying to frame a way forward and engages with controversies surrounding land policy, land law and the management of this most fundamental resource.
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McHugh, Justine. "L'influence d'un deuil pendant l'enfance sur les choix de vie des adultes qui l'ont vécu." Master's thesis, Université Laval, 2012. http://hdl.handle.net/20.500.11794/24075.
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Ce mémoire de maîtrise s'intéresse à l'expérience des adultes endeuillés dans leur enfance. Plus spécifiquement, il traite de l'influence de la perte d'un membre de la famille proche sur les choix de vie subséquents. Dans le cadre de cette recherche qualitative, 12 adultes endeuillés d'un parent ou d'un membre de la fratrie avant l'âge de 12 ans ont été interrogés sur leur perception de l'influence du deuil par rapport à leur parcours de vie. L'analyse du discours des participants met en évidence que le deuil vécu pendant l'enfance est un événement marquant et fondateur dans l'identité des personnes qui y ont été confrontées et dans la façon d'entretenir les liens affectifs. Elle met également en lumière que la perception de l'influence du deuil évolue avec le temps et avec le développement de l'individu, et ce, en fonction des contraintes et des opportunités amenées par l'environnement. De plus, elle souligne l'importante quête de sens qui demeure omniprésente au fil des différentes trajectoires ponctuant la vie des adultes endeuillés dans leur enfance. Les informations produites dans ce mémoire seront pertinentes pour l'intervention et elles contribueront à l'avancement des connaissances par rapport à une population encore peu étudiée.
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Treitl, Stefan, and Werner Jammernegg. "Facility location decisions with environmental considerations. A case study from the petrochemical industry." Springer Verlag, 2014. http://dx.doi.org/10.1007/s11573-014-0730-8.
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The recently growing concerns of customers and governments about environmental protection and greenhouse gas reduction have forced companies to integrate the topic of environmental sustainability into their decision making. Facility location decisions are of special relevance in this respect because of their strategic nature. Furthermore, many different trade-offs must be considered, for example between operational costs and customer service. But as soon as environmental issues are concerned, other critical issues must be considered as well. Based on a case study from the petrochemical industry, this paper extends two basic facility location models and shows the impact of distribution network-design decisions on the economic and environmental performance of the company. The results show a trade-off between total (distribution) costs and transport carbon emissions. (authors' abstract)
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Müllner, Jakob. "International project finance: review and implications for international finance and international business." Springer, 2017. http://dx.doi.org/10.1007/s11301-017-0125-3.
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This literature review analyzes the global phenomenon of international
project finance (PF) as both a management and finance instrument, allowing practitioners
to realize large scale infrastructure projects in high risk contexts. After describing
the characteristics of PF, its historical origins and its unique benefits for empirical
inquiry, I summarize the findings of academic research from an interdisciplinary perspective.
Based on this integration of Finance, Management and International Business
research, I discuss the theoretical implications for each field that emanate from PF.
Finally, I identify possibilities for future research and propose a more balanced, interdisciplinary
academic treatment of PF.
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Machrafi, Younes. "Impact des résidus de désencrage du papier et des stratégies de désherbage sur la rotation soya (glycine max (L.) merr)-maïs (zea mays L.)." Thesis, Université Laval, 2012. http://www.theses.ulaval.ca/2012/28477/28477.pdf.
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Macias-Valadez, Katia. "Ornementation rayonnante et décors flamboyants dans les vitraux du tympan à la fin du Moyen Âge en France." Master's thesis, Université Laval, 1993. http://hdl.handle.net/20.500.11794/33705.
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Mühlbacher, Jürgen, Tom Siebenaler, and Ulrike Würflingsdobler. "The Rise of Non-financial performance Measures in Annual Reports. An Analysis of ATX-listed Companies." Faculty of Business and Management of Brno University of Technology, 2016. http://epub.wu.ac.at/6342/1/338%2D1496%2D1%2DPB.pdf.
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Purpose of the article: In the past, annual reports only included financial measures. More recently, this
shareholder value approach has been criticized of leading to a strategic short-term orientation. Consequently,
the use of strategic performance measurement systems (SPMSs), namely the Balanced Scorecard (BSC), is
proposed to communicate non-financial measures to investors and stakeholders. Besides the distribution of
critical information, the disclosure of non-financial measures should strengthen the employees' commitment
to the long-term strategy. The purpose of the article is thus to reveal whether Austrian companies disclose their
strategic performance measures in their annual reports.
Methodology/methods: Two observation points, 2002 and 2012, were chosen to analyse the annual reports of
companies listed on the ATX. This period of time allows to observe changes as well as new trends. The annual
reports have been downloaded from the companies' homepages or received via email or post. A document and
content analysis, followed by a frequency analysis, has been applied to identify several non-financial measures
with regard to the following BSC-derived perspectives: Customer perspective, internal business perspective
and innovation and learning perspective.
Scientific aim: The scientific aim of the following study is to examine the extent to which non-financial
performance measures are displayed in annual reports.
Findings: The analysis of the annual reports showed a tremendous increase in non-financial measures in
the time period between 2002 and 2012, which solely arose from the augmented disclosure activities of the
innovation and learning perspective. On the other hand, the customer and internal perspectives decreased
in importance. Moreover, the top ten measures in 2002 have changed and are dominated by diversity and
environmental issues in the year 2012.
Conclusions: Similar findings in the literature as well as the influence of legal disclosure requirements are
discussed. Possible limitations are the sole use of the Balanced Scorecard as a SPMS or the chosen time period
of ten years.
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Gross, Logan M. "The 773rd Tank Destroyer Battalion at the Falaise Pocket, 1944: The Application of Tank Destroyer Doctrine in the Field." ScholarWorks@UNO, 2017. http://scholarworks.uno.edu/td/2324.
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During World War II, the United States Army employed a new weapon on the battlefield in an attempt to defeat German armor tactics: the tank destroyer. Tank Destroyer Force was created to stem the tide of German armored attacks and form an opening for American tanks to make their own counter-attacks. Since the end of the war, tank destroyer battalions have been regarded as a failed experiment, despite the evidence that they effectively did their jobs. The negative feedback in the immediate post-war period lead to the dissolution of the Tank Destroyer Force. Many of the studies of tank destroyers focus on the doctrine they followed and the faults in it. However, most of the studies do not look at the successful application of tank destroyer doctrine in the field by tank destroyer battalions. This paper will examine operations of the 773rd Tank Destroyer Battalion and its application of tank destroyer doctrine during the Battle of Chambois from August 17-21, 1944, for which it won a Presidential Unit Citation.
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Watkins, Aaron Emery. "A New Perspective on Galaxy Evolution From the Low Density Outskirts of Galaxies." Case Western Reserve University School of Graduate Studies / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=case1499354382030385.
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Ferreira, Tânia Kadima Magalhães. "Visão Baseada em Recursos (RBV) na gestão das operadoras de saúde de autogestão: necessidade para sustentabilidade." Master's thesis, 2019. http://hdl.handle.net/10071/20036.
Full textAbstract:
A complexidade da gestão da saúde e o alto custo da assistência médica motivaram a pesquisa. O estudo abordou a importância da aplicação da teoria RBV em empresas de autogestão da saúde como fator crítico para a heterogeneidade. Os artigos científicos foram selecionados para IDSS, IDQS e Índice de Satisfação do Cliente e indicadores econômico-financeiros no site da Agência Nacional de Saúde. Foram analisados os estatutos sociais de 99 operadoras de planos de saúde de autogestão. A discussão teórica foi sobre saúde suplementar, gestão de empresas de saúde, governança corporativa, desempenho organizacional, teoria da RBV e gestão profissionalizada. Verificou-se que a avaliação da qualificação das autogestões alcançou parcialmente os objetivos de melhoria contínua, devido às constantes mudanças nos indicadores desde 2015, verificando-se incoerência entre o resultado do IDSS (Índice de Desenvolvimento em Saúde Suplementar) e o IDQS (Índice de Desenvolvimento da Qualidade da Saúde) e Índice de satisfação do cliente medido por reclamações e resolução das pendências. Os indicadores econômico-financeiros apresentaram déficit, principalmente sinistralidade e endividamento. Governança corporativa composta por diretores nomeados e / ou eleitos. Apenas cinco autogestões de pequeno porte com ativos intangíveis raros, inimitáveis, não substituíveis e explorados pela organização (recursos internos) foram selecionadas como alto desempenho (pontuação máxima no IDQS; sustentabilidade econômico-financeira). Concluiu-se que a RBV nas empresas de autogestão é necessária para a sustentabilidade organizacional.<br>Complexity of health management and high cost of assistance medical motivated the research. The study addressed the importance of applying of the RBV theory in self-management health companies as a critical factor for heterogeneity. Scientific articles were selected for IDSS, IDQS and costumer satifaction Index and indicators economic-Financial on the website of the National Agency of Health. The social statutes of 99 self-managements health plan operators were analyzed. Theoretical discussion was about supplementary health, management health companies, corporate governance, organizational performance, RBV theory, and professionalized management. It was found that evaluation of the qualification of the health companies achieved the objectives of continuous improvement partially, due to constant changes in the indicators since 2015, so it was verified incoherence between the outcome of the IDSS (Supplementary Health Development Index) and the IDQS (Health Quality Development Index) and the costumer satisfaction Index measured by complaints and resolution of the pendencies. Economic and financial indicators showed deficit, mainly sinistrality and indebtedness. Corporate governance composed of directors appointed and/or elected. Only five small self-management health companies with rare intangible assets, inimitable, non-substitutable, and exploited by the Organization (internal resources) were selected as high performance (maximum score in the IDQS; sustainability Economic and financial). It’s concluded that RBV in the self-management companies is necessary for organizational sustainability.