Journal articles: 'M150'

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Radi, Smaail, and Hassan Lazrek. "1-[(2-Acetoxyethoxy)methyl]-3-benzyl-6-azauracil." Molecules 5, no. 12 (2000): M150. http://dx.doi.org/10.3390/m150.

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Kairakbaev, A. K., V. Z. Abdrakhimov, and E. S. Abdrakhimova. "Use of Aluminum-Containing Technogenic Raw Materials for Obtaining High-Strength Earthquake-Resistant Bricks Based on Low-Melting Clay of the Aktobe Region." Ecology and Industry of Russia 24, no. 11 (2020): 14–18. http://dx.doi.org/10.18412/1816-0395-2020-11-14-18.

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The use of nanotechnogenic petrochemical raw materials-spent IM-2201 catalyst containing more than 70 % Al2O3, and as a clay binder-lowmelting clay from the Ilek Deposit in the Aktobe region allows you to get a ceramic brick that corresponds to the M150 brand. It is possible to build load-bearing walls of the lower floors of high-rise buildings (more than 10 floors) from M150 ceramic bricks. Innovative proposals for the use of waste from production and spent catalyst in the production of ceramic high-strength earthquake-resistant bricks with increased strength and frost resistance have been developed. The absolute advantage of using multi-tonnage waste and spent catalyst IM-2201 is to relieve the environmental situation.

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Widowati, Lestari L., S. Budi Prayitno, Sri Rejeki, et al. "Organic matter reduction using four densities of seaweed (Gracilaria verucosa) and green mussel (Perna viridis) to improve water quality for aquaculture in Java, Indonesia." Aquatic Living Resources 34 (2021): 5. http://dx.doi.org/10.1051/alr/2021002.

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The high organic waste content of river water in Demak, north coast of Java, has caused traditional small-scale pond farmers to stop stocking shrimp. This paper examines whether seaweed and mussel will improve the quality of water these farmers use. The effect of Gracilaria verucosa and Perna viridis on the water quality was assessed by measuring the removal rates (RRs) of total organic material (TOM), total ammonia nitrogen (TAN), nitrite, and nitrate. The specific growth rates (SGRs) of seaweed and mussel were also measured. Thirty-six semi-outdoor tanks containing 800 L of brackish water and 7 cm substrate were randomly assigned to four replications of four densities of G. verucosa: 50 (S50), 100 (S100), 150 (S150), and 200 (S200) g m−2, and of P. viridis: 60 (M60), 90 (M90), 120 (M120), and 150 (M150) g m−2. Weekly, the TOM, TAN, nitrite, and nitrate contents were measured, seaweed and mussel weighted; RRs and SGRs were calculated at the end of the study. The effect of densities on the RRs was significant for both seaweed and mussel. P. viridis was more effective in reducing TOM (by 38%) than G. verucosa (7%); G. verucosa achieved higher RRs for TAN, nitrite, and nitrate. At S200, TOM and TAN decreased by 7.4% and 67%, respectively. At M90, TOM and TAN, decreased by 38% and 49%, respectively. However, nitrite increased significantly at S200 and M150. The SGR of seaweed was significantly lower at S200 than that at S150, S100, and S50. The best performing densities were S100 and M90.

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Sjöström, Nils, David Berg, Sofia Johansson, Eva Andreasson, and Margda Waern. "M150. RELATIVES EXPERIENCES OF THE EARLY SIGNS ACTION PLAN." Schizophrenia Bulletin 46, Supplement_1 (2020): S192. http://dx.doi.org/10.1093/schbul/sbaa030.462.

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Abstract Background In the recent years person-centered methods have been developed to involve relatives in the care of their next of kin. The Early Signs Action Plan (ESAP) was developed to facilitate relatives’ participation in the care of their next of kin in psychiatric outpatient units specialized in the treatment of persons with schizophrenia and similar disorders. The aim was to investigate relatives’ experiences regarding the activation of the action plan for their next of kin. Methods The study is a qualitative interview study using a semi-structured interview guide. The interviews were conducted with relatives (N=13) to outpatients whose Early Signs Action Plan had been activated. The interviews were digitally recorded and transcribed verbatim. The material was then analyzed with qualitative content analysis. Results ESAP was positively received by the relatives and most of them experienced that they were participating in the planning of the care of their next of kin’s. Participating in the care also implied a feeling of security and awareness about their next of kin’s early warning signs and what to do in case of a relapse. Relatives also indicated that the ESAP is vulnerable during on call time and during vacation periods. Outdated paths to get in contact with psychiatric services on call time were reported as problematic since this information is crucial for getting in touch with care outside of office hours. Discussion ESAP seems to be a useful tool for the involvement of relatives in the care of their next of kin.

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Abdrakhimova, E. S. "Recycling of Slag from the Smelting of Ferro in the Production of Earthquake Resistant Brick Based on Clay Beidellite." Ecology and Industry of Russia 25, no. 7 (2021): 32–36. http://dx.doi.org/10.18412/1816-0395-2021-7-32-36.

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A method for producing ceramic earthquake-resistant bricks based on beidellite clay used as a binder and slag from the smelting of ferrotitane used as an aluminum-containing thinning agent is considered. The resulting brick corresponded to the M150 brand, from which it is possible to build buildings of more than 10 floors.

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Goldstein, M., and R. Mindel. "M150 KOUNIS SYNDROME (KS) AND MAST CELL ACTIVATION TREATED WITH OMALIZUMAB." Annals of Allergy, Asthma & Immunology 125, no. 5 (2020): S67—S68. http://dx.doi.org/10.1016/j.anai.2020.08.222.

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Winkler, C. E., M. Levancini, C. Fernandez, et al. "M150 IMPLANO® USERS EXPERIENCE IN A PRIMARY CARE FACILITY IN SANTIAGO, CHILE." International Journal of Gynecology & Obstetrics 119 (October 2012): S581. http://dx.doi.org/10.1016/s0020-7292(12)61344-7.

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Pardo, Marta, Jordina Tor, Daniel Muñoz, et al. "Poster #M150 CANNABIS USE IN A SAMPLE OF SUBJECTS AT RISK FOR DEVELOPING PSYCHOSIS." Schizophrenia Research 153 (April 2014): S244—S245. http://dx.doi.org/10.1016/s0920-9964(14)70700-5.

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Blazer, D. G. "Guest Editorial The Prevalence of Depressive Symptoms." Journals of Gerontology Series A: Biological Sciences and Medical Sciences 57, no. 3 (2002): M150—M151. http://dx.doi.org/10.1093/gerona/57.3.m150.

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Wolf, Nicole M., Kristin Mueller, Frank Hirche, Erika Most, Josef Pallauf, and Andreas S. Mueller. "Study of molecular targets influencing homocysteine and cholesterol metabolism in growing rats by manipulation of dietary selenium and methionine concentrations." British Journal of Nutrition 104, no. 4 (2010): 520–32. http://dx.doi.org/10.1017/s0007114510000899.

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Inconsistent results exist from human and animal studies for Se and methionine (Met) regarding their influence on homocysteine (HCys) and cholesterol (Chol) metabolism. To elucidate these contradictions, sixty-four weanling albino rats were divided into eight groups of 8, and were fed diets containing four different Se levels (15, 50, 150 and 450 μg/kg) either in combination with the recommended Met level of 3 g/kg (C15, C50, C150 and C450) or with an increased Met concentration of 15 g/kg (M15, M50, M150 and M450) for 8 weeks. Plasma HCys was twofold higher in the Se-supplemented C groups than in group C15. Met addition also doubled plasma HCys compared with the respective C groups. In contrast, the expression of the key enzymes of glutathione biosynthesis in the liver was significantly lowered by Se and in particular by Met. Liver Chol concentration was significantly higher in all the Se-supplemented C and M groups than in groups C15 and M15. Plasma Chol was, however, lowered. The uninfluenced expression of sterol-regulatory element-binding protein 2 and of hydroxymethyl-glutaryl-CoA reductase, the increased LDL receptor expression and the reduced expression of the hepatobiliary Chol exporter ATP-binding-cassette-transporter 8 (ABCG8) by Se and/or Met explain these findings. We conclude that the elevation of plasma HCys in rats by Se and Met results from a higher export into plasma. The fact that Se in particular combined with Met increases liver Chol but reduces plasma Chol should be addressed in future investigations focussing on the regulation of ABCG8, which is also selectively involved in the reverse transport of phytosterols in the small intestine.

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Prasad, Durbaka V. R., Vrajesh V. Parekh, Bimba N. Joshi, et al. "The Th1-Specific Costimulatory Molecule, M150, Is a Posttranslational Isoform of Lysosome-Associated Membrane Protein-1." Journal of Immunology 169, no. 4 (2002): 1801–9. http://dx.doi.org/10.4049/jimmunol.169.4.1801.

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Grivcheva-Panovska, V., and B. Giannetti. "M150 FIRST DOCUMENTED CASE OF HEREDITARY ANGIOEDEMA ATTACK IN UTERO AND TREATMENT OF MOTHER AND FETUS." Annals of Allergy, Asthma & Immunology 123, no. 5 (2019): S87. http://dx.doi.org/10.1016/j.anai.2019.08.150.

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Bennett, G. S., and C. DiLullo. "Slow posttranslational modification of a neurofilament protein." Journal of Cell Biology 100, no. 5 (1985): 1799–804. http://dx.doi.org/10.1083/jcb.100.5.1799.

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The synthesis and subsequent modification of neurofilament (NF) polypeptides has been examined in pulse-chase experiments, using cultured chick spinal cord neurons. Fluorography of the [35S]methionine-labeled cytoskeletal proteins, after separation by two-dimensional gel electrophoresis, revealed that (a) the mid-size chicken NF protein, NF-M160, is synthesized as a smaller and more basic precursor, NF-M130; (b) beginning approximately 8 h after translation, NF-M130 slowly and continuously becomes larger and more acidic, attaining the size and charge of NF-M160 16 or more h later, and undergoing no further change in mobility for many days thereafter; and (c) in contrast, the low molecular weight NF protein, NF-L, is synthesized as such, and undergoes no subsequent change in apparent size or charge. Additional experiments provided evidence that the conversion of NF-M130 to NF-M160 is due, at least in part, to phosphorylation: (a) Incubation of similar cultures in 32PO4 resulted in incorporation into NF-M160 and transitional forms, but not into NF-M130. (b) An antiserum to NF-M160 was found by immunoblot analysis to bind strongly to untreated NF-M160, but poorly to phosphatase-treated NF-M160, and not at all to NF-M130. It has already been demonstrated (Bennett, G. S., S. J. Tapscott, C. DiLullo, and H. Holtzer, 1984, Brain Res., 304:291-302) that this anti-NF-M160 fails to stain the soma of motor neurons in sections of chick spinal cord, but detects an increasing gradient of immunoreactivity in the proximal axons. These results, together with the known kinetics of axoplasmic transport of NF, suggest that the mid-size chicken NF protein is synthesized as NF-M130 and is extensively modified, at least in part by phosphorylation, to become NF-M160 during transport along proximal neurites. Once maximally modified, NF-M160 undergoes no further net change during transport along distal neurites.

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Riyazahmed, K. "NEURAL NETWORKS IN FINANCE: A DESCRIPTIVE SYSTEMATIC REVIEW." Indian Journal of Finance and Banking 5, no. 2 (2021): 1–27. http://dx.doi.org/10.46281/ijfb.v5i2.997.

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Traditional statistical methods pose challenges in data analysis due to irregularity in the financial data. To improve accuracy, financial researchers use machine learning architectures for the past two decades. Neural Networks (NN) are a widely used architecture in financial research. Despite the wider usage, NN application in finance is yet to be well defined. Hence, this descriptive study classifies and examines the NN application in finance into four broad categories i.e., investment prediction, credit evaluation, financial distress, and other financial applications. Likewise, the review classifies the NN methods used under each category into standard, optimized and hybrid NN. Further, accuracy measures used by the research work widely differ, in turn, pose challenges for comparison of a NN under each category and reduces the scope of formalizing a theory to choose optimum network model under each category.  JEL Classification Codes: G1, G17, M150.

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AGREWALA, JAVED N., SUSMIT SUVAS, ANEESH JOSHI, ARCHANA BHATNAGAR, DASS S. VINAY, and GYAN C. MISHRA. "M150 Modulates the Costimulatory Signals Delivered by B Cells to T Cells and Enhances Their Ability to Help B Cells." Journal of Interferon & Cytokine Research 18, no. 5 (1998): 297–304. http://dx.doi.org/10.1089/jir.1998.18.297.

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Tommaselli, A. M. G., M. V. A. Moraes, L. S. L. Silva, M. F. Rubio, G. J. Carvalho, and J. T. G. Tommaselli. "Monitoring marginal erosion in hydroelectric reservoirs with terrestrial mobile laser scanner." ISPRS - International Archives of the Photogrammetry, Remote Sensing and Spatial Information Sciences XL-5 (June 6, 2014): 589–96. http://dx.doi.org/10.5194/isprsarchives-xl-5-589-2014.

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Marginal erosions in reservoirs of hydroelectric plants have caused economic and environmental problems concerning hydroelectric power generation, reduction of productive areas and devaluing land parcels. The real extension and dynamics of these erosion processes are not well known for Brazilian reservoirs. To objectively assess these problems Unesp (Univ Estadual Paulista) and Duke Energy are developing a joint project which aims at the monitoring the progression of some erosive processes and understanding the causes and the dynamics of this phenomenon. Mobile LASER scanning was considered the most suitable alternative for the challenges established in the project requirements. A MDL DynaScan Mobile LASER M150 scanner was selected which uses RTK for real time positioning integrated to an IMU, enabling instantaneous generation of georeferenced point clouds. Two different reservoirs were choose for monitoring: Chavantes (storage plant) and Rosana (run-of-river plant), both in the Paranapanema River, border of São Paulo and Paraná States, Brazil. The monitoring areas are scanned quarterly and analysed with base on the point cloud, meshes, contours and cross sections. Cross sections are used to visualize and compute the rate and the dynamics of erosion. Some examples and quantitative results are presented along with an analysis of the proposed technique. Some recommendations to improve the field work and latter data processing are also introduced.

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SUVAS, S., H. VOHRA, and J. N. AGREWALA. "Modulation of the expression of M150 on macrophages by Th1/Th2 cytokines and co-stimulatory molecules CD40, B7-1, B7-2 and ICAM-1." Clinical & Experimental Immunology 134, no. 2 (2003): 232–37. http://dx.doi.org/10.1046/j.1365-2249.2003.02283.x.

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Karani, Anushree, Heena Thanki, and Sarla Achuthan. "Impact of University Website Usability on Satisfaction: A Structural Equation Modelling Approach." Management and Labour Studies 46, no. 2 (2021): 119–38. http://dx.doi.org/10.1177/0258042x21989924.

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One of the many ways through which the universities can communicate with students is through their website, which is considered as the face of the organization. It also represents the organization as a whole, its culture, value and vision. The current study aimed to check the usability of Gujarat Technological University’s website from students’ perspective and to find its association with satisfaction. The current study tried to address the gap in the literature, wherein in the Indian context, the majority studies were conducted in the context of library website only. The current study has adopted a quantitative approach, where a single cross-sectional research design has been used with convenience sampling. The present study had adapted the Website Usability Evaluation (WEBUSE) scale. A total of 577 students from the fields of management, computer science, and engineering have responded to the structured questionnaire. The structural equation model of the study revealed that all the four dimensions of website usability were positively associated with satisfaction, whereas content, organization and readability criterion had the most influence on satisfaction followed by user interface design, performance and effectiveness and navigation and links. The study strongly recommends the university to maintain up-to-date content, organize it well and it should be readable for the students in order to maximize the satisfaction with the website. JEL Codes: I230, M150

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Gaishun, Evgeny, Khungiaonos Yavruyan, Vladimir Kotlyar, and Elizaveta Lotoshnikova. "Raw Materials in East Donbass Based on Waste Piles Processing Screenings for the Large-Sized Ceramic Stones’ Production." Materials Science Forum 1011 (September 2020): 116–22. http://dx.doi.org/10.4028/www.scientific.net/msf.1011.116.

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The article shows the prospects of using large-sized ceramic stones for modern housing construction. A review of the raw materials and technologies for their production is given. It is emphasized that the most promising technology for the large-sized ceramic stones’ production is a hard extrusion technology with the possibility of laying raw products on firing buggies and accelerated drying and firing modes. The characteristic of waste piles processing screenings in East Donbass, which are considered to be the by-products of coal mining, as the main raw material for the large-sized ceramic stones’ production is given. Their ceramic properties and results of the raw materials’ selection are given, including: screenings - 60-65%; siliceous clay - 20-30% coal sludge - 10-15%, on the basis of which it is possible to obtain the products with low cost and high strength for the load-bearing wall structures. The features of the ceramic material microstructure based on the obtained raw material mixtures with optimal porosity are noted. It is shown that the waste piles’ involvement in the process of ceramic stones production will make it possible to obtain products with a density of less than 800 kg/m3, less thermal conductivity 0,20 m·°С)/W and the brand strength M150 and above, with a minimum cost. This will create a serious competition for gas silicate products and achieve a level of ceramic stones’ use in the total volume of wall products for the housing construction of 80%, like in Western Europe.

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Abdrakhimov, V. Z. "THE USE OF WASTE MINERAL WOOL IN THE PRODUCTION OF CERAMIC WALL MATERIALS." Construction and Geotechnics 10, no. 3 (2019): 53–60. http://dx.doi.org/10.15593/2224-9826/2019.3.06.

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The environmental situation in Russia is characterized by a high level of anthropogenic impact on the environment, significant environmental consequences of past economic activity. Their disposal and storage costs 8-10 % of the cost of products, so the disposal of such waste is of paramount importance.Due to the involvement of multi-tonnage waste in the production of ceramic materials of mass consumption, which include wall materials, it is possible to radically change the parameters of the raw material base of Russia, which also helps to reduce environmental tensions in the regions. The reduction of reserves of traditional natural raw materials makes us look for new ways to replace it with different types of waste. The experience of advanced foreign countries has shown the technical feasibility of this area and the use of more as a tool to protect the environment from pollution. However, almost all basic building materials can be made from waste or from waste in combination with natural raw materials. On the basis of fusible clay and waste basalt-gabbro-norite charge, which is formed in the production of mineral wool obtained ceramic brick with high physical and mechanical properties, brick grade M150 and above. The absolute advantage of the use of multi-tonnage waste is the unloading of the environmental situation, which contributes to the solution of industrial waste disposal and environmental protection. Innovative proposals for the use of waste from the production of mineral wool in the production of wall materials - ceramic bricks based on fusible clay, the novelty of which is confirmed by patents of the Russian Federation.

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Werden, Steven J., Jerry Lanchbury, Donna Shattuck, Chris Neff, Max Dufford, and Grant McFadden. "The Myxoma Virus M-T5 Ankyrin Repeat Host Range Protein Is a Novel Adaptor That Coordinately Links the Cellular Signaling Pathways Mediated by Akt and Skp1 in Virus-Infected Cells." Journal of Virology 83, no. 23 (2009): 12068–83. http://dx.doi.org/10.1128/jvi.00963-09.

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ABSTRACT Most poxviruses express multiple proteins containing ankyrin (ANK) repeats accounting for a large superfamily of related but unique determinants of poxviral tropism. Recently, select members of this novel family of poxvirus proteins have drawn considerable attention for their potential roles in modulating intracellular signaling networks during viral infection. The rabbit-specific poxvirus, myxoma virus (MYXV), encodes four unique ANK repeat proteins, termed M-T5, M148, M149, and M150, all of which include a carboxy-terminal PRANC domain which closely resembles a cellular protein motif called the F-box domain. Here, we show that each MYXV-encoded ANK repeat protein, including M-T5, interacts directly with the Skp1 component of the host SCF ubiquitin ligase complex, and that the binding of M-T5 to cullin 1 is indirect via binding to Skp1 in the host SCF complex. To understand the significance of these virus-host protein interactions, the various binding domains of M-T5 were mapped. The N-terminal ANK repeats I and II were identified as being important for interaction with Akt, whereas the C-terminal PRANC/F-box-like domain was essential for binding to Skp1. We also report that M-T5 can bind Akt and the host SCF complex (via Skp1) simultaneously in MYXV-infected cells. Finally, we report that M-T5 specifically mediates the relocalization of Akt from the nucleus to the cytoplasm during infection with the wild-type MYXV, but not the M-T5 knockout version of the virus. These results indicate that ANK/PRANC proteins play a critical role in reprogramming disparate cellular signaling cascades to establish a new cellular environment more favorable for virus replication.

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Hasan, Milena, Astrid Krmpotic, Zsolt Ruzsics, et al. "Selective Down-Regulation of the NKG2D Ligand H60 by Mouse Cytomegalovirus m155 Glycoprotein." Journal of Virology 79, no. 5 (2005): 2920–30. http://dx.doi.org/10.1128/jvi.79.5.2920-2930.2005.

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ABSTRACT Both human and mouse cytomegaloviruses (CMVs) encode proteins that inhibit the activation of NK cells by down-regulating cellular ligands for the activating NK cell receptor NKG2D. Up to now, three ligands for the NKG2D receptor, named RAE-1, H60, and MULT-1, have been identified in mice. The resistance of mouse strains to murine CMV (MCMV) infection is determined by their ability to generate an effective NK cell response. The MCMV gene m152, a member of the m145 gene family, down-regulates the expression of RAE-1 in order to avoid NK cell control in vivo. Here we report that the m155 gene, another member of the m145 gene family, encodes a protein that interferes with the expression of H60 on the surfaces of infected cells. Deletion of the m155 gene leads to an only partial restoration of H60 expression on the cell surface, suggesting the involvement of another, so far unknown, viral inhibitor. In spite of this, an m155 deletion mutant virus shows NK cell-dependent attenuation in vivo. The acquisition of endo-β-N-acetylglucosaminidase H resistance and the preserved half-life of H60 in MCMV-infected cells indicate that the m155-mediated effect must take place in a compartment after H60 exits from the ERGIC-cis-Golgi compartment.

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Zhang, Liandong, Ming Gao, Tongdian Zhang, et al. "Protective Effects of Genistein against Mono-(2-ethylhexyl) Phthalate-Induced Oxidative Damage in Prepubertal Sertoli Cells." BioMed Research International 2017 (2017): 1–12. http://dx.doi.org/10.1155/2017/2032697.

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Mono-(2-ethylhexyl) phthalate (MEHP) and genistein are two of the most prevalent endocrine-disrupting chemicals (EDCs) that present in the environment and food. However, how these two EDCs would affect prepubertal Sertoli cells development was rarely studied. In this study, primary prepubertal Sertoli cells were isolated from 22-day-old Sprague Dawley rats and exposed to MEHP at 1 μmol/L, 10 μmol/L, and 100 μmol/L (M1, M10, and M100), genistein at 10 μmol/L (G), and their combination (G + M1, G + M10, and G + M100). Cell proliferation inhibition rate, apoptosis and necrosis rate, and cellular redox state were evaluated. Our results revealed that MEHP could significantly increase cell proliferation inhibition rate, apoptosis rate, necrosis rate, and intracellular reactive oxidative species level. However, coadministration of genistein could partially alleviate MEHP-induced prepubertal Sertoli cells oxidative injuries via enhancement of testicular antioxidative enzymes activities and upregulation of Nrf2 and HO-1, indicating that genistein could partially attenuate MEHP-induced prepubertal Sertoli cells damage through antioxidative action and may have promising future on its curative role for attenuating other EDCs-induced reproductive disorders.

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Wu, Ze Xu, and Yin Shan Wang. "Experimental Study on Emission Characteristics of Methanol Gasoline in the GW491QE Engine." Advanced Materials Research 986-987 (July 2014): 841–43. http://dx.doi.org/10.4028/www.scientific.net/amr.986-987.841.

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M10, M15, M50 methanol gasoline and 93 # gasoline engine emission performance test were researched on the engine GW491QE. Always stayed in 60 N·m torque and rotational speed increased from 1000 r/min to 3000 r/min, recorded the corresponding data, performance, emission performance curve was drawn respectively, comparison and analysis, the influencing factors of GW491QE engine emission performance were discussed, practical application on engine GW491QE suitable blending ratio of methanol gasoline was chosen. The experimental results show that: three kinds of methanol gasoline of HC emissions is lower, M15 improvement is most obvious; NOx emissions are reduced. GW491QE engine emission performance is taken into account, M15 methanol gasoline is a good proportion of the actual application.

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Bunnell, Kristen L., Eric Wenzler, Larry H. Danziger, and Keith A. Rodvold. "Clearance of ceftazidime-avibactam in an in vitro continuous venovenous hemodialysis model." Open Forum Infectious Diseases 4, suppl_1 (2017): S294—S295. http://dx.doi.org/10.1093/ofid/ofx163.675.

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Abstract Background Optimal dosing of ceftazidime-avibactam (C-A) in critically ill patients on continuous renal replacement therapy (CRRT) is unknown. The objective of this study was to evaluate the adsorption and transmembrane clearance (CLTM) of C-A in an in vitro continuous venovenous hemodialysis (CVVHD) model to guide dosing in the absence of clinical data. Methods CVVHD was simulated with bovine blood (200 mL/minute) on a Prismaflex dialysis unit with polysulfone (HF1400) and AN69 (M150) hemofilters at dialysate flow rates (Qd) of 2 and 4 L/hours. Pre-hemofilter plasma samples were collected at 0, 5, 10, 20, 30, 45, and 60 mins after C-A addition; postfilter and dialysate samples were collected at 10 and 45 mins for saturation coefficient (SA) calculation. Adsorption was determined by total drug recovery in dialysate and plasma after 120 mins of dialysis at 2 L/hours. CLTM was calculated as the product of SA and Qd (CLTM-SA) and by elimination rate constant (CLTM-ke) derived from the slope of log-linear concentration-time plots. Results Mean (± SD) SA and CLTM values for C-A from duplicate experiments are in Table 1. CLTM was not affected by filter type, and increased linearly with Qd when calculated by two different methods. Avibactam CLTM was higher than ceftazidime CLTM with each filter and rate. Adsorption affected 17.3% and 20.2% of C-A for HF1400 and AN69 filters, respectively. Conclusion Significant Qd- dependent clearance of C-A was observed in in vitro CVVHD. CLTM of ceftazidime was slightly higher than previous reports and may reflect the larger surface area of contemporary filters in this study. The more rapid clearance of avibactam, particularly at higher flow rates, suggests that dose adjustments should focus on ensuring adequate avibactam exposure during CVVHD. Disclosures L. H. Danziger, Allergan: Investigator, Research grant.

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Pereira, Sóstenes A. R. S., Fernanda V. Henrique, Lylian K. G. Medeiros, et al. "Anesthetic quality and cardiovascular and respiratory effects of continuous intravenous infusion of tiletamine-zolazepam in bitches." Pesquisa Veterinária Brasileira 39, no. 3 (2019): 214–20. http://dx.doi.org/10.1590/1678-5150-pvb-5827.

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ABSTRACT: The objective of this study was to evaluate the quality and recovery from anesthesia promoted by the tiletamine-zolazepam (TZ) combination administered intravenously (IV) continuously in bitches pre-medicated with acepromazine. Eight cross-bred, clinically healthy bitches weighing 13.7 ±1.9kg on average were used in this study. After a food fast of 12 h and a water fast of four hours, the animals were treated with acepromazine (0.1mg/kg, intramuscular) and, after 15 minutes, anesthesia was induced with a combination of tiletamine-zolazepam (2mg/kg, IV) immediately followed by continuous IV infusion thereof at a dose of 2mg/kg/h for 60 min. The following parameters were measured in all animals immediately before administration of acepromazine (M15), immediately before anesthetic induction (M0), and at 5, 10, 20, 30, 40, 50, and 60 min after initiation of continuous infusion (M5, M10, M20, M30, M40, M50, and M60): electrocardiography (ECG), heart rate (HR), mean arterial pressure (MAP), respiratory rate (RR), body temperature (BT), and arterial hemogasometry, with the last performed only at experimental times M15, M0, M30, and M60. A subcutaneous electrical stimulator was used to evaluate the degree of analgesia. Myorelaxation and quality of anesthetic recovery were also assessed, classifying these parameters as excellent, good, and poor. Anesthetic recovery time was recorded in minutes. HR increased significantly at time M10 in relation to that at M-15, and at times M5, M10, M40, and M50 in relation to that at M0. MAP decreased significantly at M20 and M30 compared with the baseline. BT decreased significantly at M50 compared with that at M0, but no hypothermia was observed. RR showed significant reduction at M5, M10, and M20 in relation to that at M-15, and at M5 and M10 in relation to that at M0, and bradypnoea was observed during the first 20 min after anesthetic induction. Significant decreases in the PR interval at times M10, M40, and M50 were observed in relation to that at M15. Amplitude of the R wave showed significant decrease at M20 compared with that at M-15. In the other ECG parameters, no significant difference was observed between the times evaluated. Hemogasometric parameters and analgesia did not show significant alterations. Myorelaxation and quality of anesthetic recovery were considered excellent. Recovery time was 15.1±7.7 min for positioning of sternal decubitus and 45.5±23.1 minutes for return of ambulation. Continuous IV administration of TZ combination does not produce satisfactory analgesia and does not cause severe cardiorespiratory and hemogasometric effects in bitches pre-medicated with acepromazine.

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Yu, Charles. "M130." Ploughshares 46, no. 2 (2020): 167–84. http://dx.doi.org/10.1353/plo.2020.0106.

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Arapović, Jurica, Tihana Lenac, Ronald Antulov, et al. "Differential Susceptibility of RAE-1 Isoforms to Mouse Cytomegalovirus." Journal of Virology 83, no. 16 (2009): 8198–207. http://dx.doi.org/10.1128/jvi.02549-08.

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ABSTRACT The NKG2D receptor is one of the most potent activating natural killer cell receptors involved in antiviral responses. The mouse NKG2D ligands MULT-1, RAE-1, and H60 are regulated by murine cytomegalovirus (MCMV) proteins m145, m152, and m155, respectively. In addition, the m138 protein interferes with the expression of both MULT-1 and H60. We show here that one of five RAE-1 isoforms, RAE-1δ, is resistant to downregulation by MCMV and that this escape has functional importance in vivo. Although m152 retained newly synthesized RAE-1δ and RAE-1γ in the endoplasmic reticulum, no viral regulator was able to affect the mature RAE-1δ form which remains expressed on the surfaces of infected cells. This differential susceptibility to downregulation by MCMV is not a consequence of faster maturation of RAE-1δ compared to RAE-1γ but rather an intrinsic property of the mature surface-resident protein. This difference can be attributed to the absence of a PLWY motif from RAE-1δ. Altogether, these findings provide evidence for a novel mechanism of host escape from viral immunoevasion of NKG2D-dependent control.

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Henrique, F. V., S. A. R. S. Pereira, L. F. Batista, et al. "Anestesia intravenosa contínua com cetamina racêmica ou dextrocetamina e detomidina em cadelas." Arquivo Brasileiro de Medicina Veterinária e Zootecnia 73, no. 1 (2021): 62–72. http://dx.doi.org/10.1590/1678-4162-11734.

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RESUMO Objetivou-se com este estudo comparar a associação de detomidina e cetamina ou dextrocetamina, por via intravenosa contínua, em oito cadelas submetidas a dois protocolos: GCD - indução anestésica com 5mg/kg e infusão intravenosa contínua de 20mg/kg/h de cetamina; e GDD - indução com 3,5mg/kg e infusão de 14mg/kg/h de dextrocetamina. Associou-se detomidina, 30µg/kg/h, em ambos os grupos. Registraram-se frequência cardíaca (FC), pressão arterial (PA), frequência respiratória (f), temperatura (TC), miorrelaxamento, analgesia, hemogasometria e eletrocardiograma, antes e 15 minutos após a MPA (Mbasal e Mmpa); após o início da infusão (Mic); a cada 10 minutos até 90 minutos (M10, M20, M30, M40, M50, M60, M70, M80 e M90); e 30 minutos após o fim da infusão (M120). Foi observada bradicardia em Mmpa no GCD e de Mmpa a M10 no GDD. Ocorreu hipotensão em Mmpa e hipertensão a partir de Mic. A f diminuiu de M10 a M30. Foram observados: onda T de alta amplitude, bloqueios atrioventriculares e parada sinusal. Ocorreu acidose respiratória. O período de recuperação foi de 219,6±72,3 minutos no GCD e de 234,1±96,8 minutos no GDD. A cetamina e a dextrocetamina, associadas à detomidina por infusão contínua, causam efeitos cardiorrespiratórios e anestésicos similares.

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Liu, Wen Yong, Peng Yang, Yong Zhang, and Yong Ye An. "Analysis of the Dry Mortar Produced with Iron Tailings." Advanced Materials Research 295-297 (July 2011): 1335–40. http://dx.doi.org/10.4028/www.scientific.net/amr.295-297.1335.

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This essay is the subject of national eleventh five support schemes: The analysis of key technology on emission reduction and comprehension utilization of solid waste from large iron ore mine (Number:2008BAB32B14). The purpose of this test is to replace natural sand with the same amount of iron tailings and find a new technology method to utilize solid waste, iron tailings, efficiently and valuably. Pre-determined cement, fly ash and cellulose ether are reasonable, which guaranteed the expected results of iron tailings instead of natural sand test .The proportion of iron tailings to replace natural sand is 0, 30%, 50%, 80%, 100%. Proportion design of M5, M7.5, M10, M15, M20 iron tailings dry mortar is determined by preliminary test. Respectively test water consumption, consistency and folding strength and compressive strength in 3d, 7d and 28d. Experiment results showed that the cementing material, PO42.5 cement made in Heng-sheng-ran Building Material Technology Co., Ltd. Beijing, has a good effect on smaller solid particles of iron tailings. After analyzing test data result, according to the provisions of “Specification for mix proportion design of masonry mortar” (JGJ 98-2000), In accordance with the principles of maximum using iron tailings and higher strength in 28d, recommended proportion of M5, M7.5, M10, M15, M20 iron tailings dry mortar has been determined. The test result will be used by actual production test.

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Huang, Hong Liang, Hui Fang Zhang, Yan Fang Li, Wen Yu, and Fei Zhao. "Experimental Study of Influence of Composed Materials on Masonry Mortar’s Workability." Advanced Materials Research 578 (October 2012): 117–20. http://dx.doi.org/10.4028/www.scientific.net/amr.578.117.

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In the experiment the author selected different materials, and designed 40 kinds of mixture proportions according to four strengths M5, M7.5, M10 and M15 of common masonry mortar. During a period of nearly seven months, the author has conducted all the business of every step involved in the process like trial mix, mixing, forming, form removal, curing and intensity test. Finally through analysis and comparison of Workability of masonry mortar mixture, the author looks forward to figuring out an ideal mixture pattern and its proportion between the materials within the group.

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Bőgel, György, and Attila Papp. "Üzleti intelligencia stratégiai nézőpontból." Competitio 7, no. 2 (2008): 49–70. http://dx.doi.org/10.21845/comp/2008/2/3.

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Az üzleti intelligencia a vállalati informatika egyik leglátványosabban és leggyorsabban fejlődő területe. A cikk összefoglalja a tárgykörhöz kapcsolódó szemléletmódok, modellek és alkalmazások több évtizedes történetét, bemutatja az átlagon felüli növekedés mozgatórugóit, megvilágítva az üzleti intelligencia szerepét a vállalatok stratégiájában. Átfogó képet ad az idetartozó informatikai alkalmazások és szolgáltatások piacának keresleti és kínálati oldaláról, kiemelve a fontosabb jelenségeket és tendenciákat. Külön foglalkozik a közelmúlt fontos vállalatfelvásárlási lépéseinek magyarázatával, elemezve az integráció iránti igény stratégiai következményeit, modellezve a fejlődés logikáját. A tanulmány a változó alkalmazási körülmények és feltételek lehetséges hatásainak felvázolásával zárul. Journal of Economic Litearture (JEL) kód: M10, M15, M40

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Rocchetti, Gabriele, Corrado Rizzi, Gabriella Pasini, Luigi Lucini, Gianluca Giuberti, and Barbara Simonato. "Effect of Moringa oleifera L. Leaf Powder Addition on the Phenolic Bioaccessibility and on In Vitro Starch Digestibility of Durum Wheat Fresh Pasta." Foods 9, no. 5 (2020): 628. http://dx.doi.org/10.3390/foods9050628.

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Fresh pasta was formulated by replacing wheat semolina with 0, 5, 10, and 15 g/100 g (w/w) of Moringa oleifera L. leaf powder (MOLP). The samples (i.e., M0, M5, M10, and M15 as a function of the substitution level) were cooked by boiling. The changes in the phenolic bioaccessibility and the in vitro starch digestibility were considered. On the cooked-to-optimum samples, by means of ultra-high-performance liquid chromatography-quadrupole time-of-flight (UHPLC-QTOF) mass spectrometry, 152 polyphenols were putatively annotated with the greatest content recorded for M15 pasta, being 2.19 mg/g dry matter (p < 0.05). Multivariate statistics showed that stigmastanol ferulate (VIP score = 1.22) followed by isomeric forms of kaempferol (VIP scores = 1.19) and other phenolic acids (i.e., schottenol/sitosterol ferulate and 24-methylcholestanol ferulate) were the most affected compounds through the in vitro static digestion process. The inclusion of different levels of MOLP in the recipe increased the slowly digestible starch fractions and decreased the rapidly digestible starch fractions and the starch hydrolysis index of the cooked-to-optimum samples. The present results showed that MOLP could be considered a promising ingredient in fresh pasta formulation.

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Carr, Vaughan J., Jessica Bowen, and Melissa J. Green. "Poster #M105 SCHIZOTAXIA REDUX." Schizophrenia Research 153 (April 2014): S228. http://dx.doi.org/10.1016/s0920-9964(14)70655-3.

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35

Jones, R. N. "NCCLS supplement M100-S2." Antimicrobic Newsletter 5, no. 2 (1988): 9–10. http://dx.doi.org/10.1016/0738-1751(88)90028-7.

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Chowdhury, Sakufa, and Md Mizanur Rahman. "The Potentiality of Women Entrepreneurs in Bangladesh with Special Reference to Sylhet Region." Global Disclosure of Economics and Business 3, no. 2 (2014): 121–30. http://dx.doi.org/10.18034/gdeb.v3i2.155.

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This paper justifies the potentiality of the women entrepreneurs in Bangladesh. For this purpose, Sylhet is taken as a study area which can be the prospective sectors for the women entrepreneurs. Huge amount of foreign remittance comes here from abroad that can be utilized in this sector successfully, and the mindset of people are not so fundamental. All of these issues are supporting to work in this region. Besides these, studying in this sector it is found that the women entrepreneurs of this region are more industrious, self-confident, dynamic, ambitious, adaptable and possess risk taking capacity and last but not the least are creative and innovative. It is obviously profitable sector which is clear after analyzing the data. Attempts also have been made here to find out the characteristics and the contributions of the women entrepreneurs to prove themselves not only as the emerging tigers but also as the economically empowered, solvent, respected and above all a contributor in the national income in this third world country, the obstacles they are facing and also the probable solutions in this context. JEL Classification Code: M100, M130

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Albrink, Michael, Connor Morton, Desiree Villadolid, et al. "M1506 Single Incision Laparoscopic Cholecystectomy." Gastroenterology 134, no. 4 (2008): A—862. http://dx.doi.org/10.1016/s0016-5085(08)64039-1.

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Ignjatovic, Ana, Andreas Varnavas, James E. East, et al. "M1510: Computer Aided Polyp Characterisation." Gastrointestinal Endoscopy 71, no. 5 (2010): AB240—AB241. http://dx.doi.org/10.1016/j.gie.2010.03.510.

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39

Murata, K., K. Hirano, E. Villa-Moruzzi, D. J. Hartshorne, and D. L. Brautigan. "Differential localization of myosin and myosin phosphatase subunits in smooth muscle cells and migrating fibroblasts." Molecular Biology of the Cell 8, no. 4 (1997): 663–73. http://dx.doi.org/10.1091/mbc.8.4.663.

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Myosin II light chains (MLC20) are phosphorylated by a Ca2+/calmodulin-activated kinase and dephosphorylated by a phosphatase that has been purified as a trimer containing the delta isoform of type 1 catalytic subunit (PP1C delta), a myosin-binding 130-kDa subunit (M130) and a 20-kDa subunit. The distribution of M130 and PP1C as well as myosin II was examined in smooth muscle cells and fibroblasts by immunofluorescence microscopy and immunoblotting after differential extraction. Myosin and M130 colocalized with actin stress fibers in permeabilized cells. However, in nonpermeabilized cells the staining for myosin and M130 was different, with myosin mostly at the periphery of the cell and the M130 appearing diffusely throughout the cytoplasm. Accordingly, most M130 was recovered in a soluble fraction during permeabilization of cells, but the conditions used affected the solubility of both M130 and myosin. The PP1C alpha isoform colocalized with M130 and also was in the nucleus, whereas the PP1C delta isoform was localized prominently in the nucleus and in focal adhesions. In migrating cells, M130 concentrated in the tailing edge and was depleted from the leading half of the cell, where double staining showed myosin II was present. Because the tailing edge of migrating cells is known to contain phosphorylated myosin, inhibition of myosin LC20 phosphatase, probably by phosphorylation of the M130 subunit, may be required for cell migration.

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Tripathy, Sandeep K., Hamish R. C. Smith, Erika A. Holroyd, Jeanette T. Pingel, and Wayne M. Yokoyama. "Expression of m157, a Murine Cytomegalovirus-Encoded Putative Major Histocompatibility Class I (MHC-I)-Like Protein, Is Independent of Viral Regulation of Host MHC-I." Journal of Virology 80, no. 1 (2006): 545–50. http://dx.doi.org/10.1128/jvi.80.1.545-550.2006.

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ABSTRACT A murine cytomegalovirus (MCMV)-encoded protein, m157, has a putative major histocompatibility complex class I (MHC-I) structure and is recognized by the Ly49H NK cell activation receptor. Using a monoclonal antibody against m157, in this study we directly demonstrated that m157 is a cell surface-expressed glycophosphatidylinositol-anchored protein with early viral gene kinetics. Beta-2 microglobulin and TAP1 (transporter associated with antigen processing 1) were not required for its expression. MCMV-encoded proteins that down-regulate MHC-I did not affect the expression of m157. Thus, m157 is expressed on infected cells in a manner independent of viral regulation of host MHC-I.

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Bubić, Ivan, Markus Wagner, Astrid Krmpotić, et al. "Gain of Virulence Caused by Loss of a Gene in Murine Cytomegalovirus." Journal of Virology 78, no. 14 (2004): 7536–44. http://dx.doi.org/10.1128/jvi.78.14.7536-7544.2004.

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ABSTRACT Mouse strains are either resistant or susceptible to murine cytomegalovirus (MCMV). Resistance is determined by the Cmv1r (Ly49h) gene, which encodes the Ly49H NK cell activation receptor. The protein encoded by the m157 gene of MCMV has been defined as a ligand for Ly49H. To find out whether the m157 protein is the only Ly49H ligand encoded by MCMV, we constructed the m157 deletion mutant and a revertant virus. Viruses were tested for susceptibility to NK cell control in Ly49H+ and Ly49H− mouse strains. Deletion of the m157 gene abolished the viral activation of Ly49H+ NK cells, resulting in higher virus virulence in vivo. Thus, in the absence of m157, Ly49H+ mice react like susceptible strains. 129/SvJ mice lack the Ly49H activation NK cell receptor but express the inhibitory Ly49I NK cell receptor that binds to the m157 protein. The Δm157 inhibitory phenotype was weak because MCMV encodes a number of proteins that mediate NK inhibition, whose contribution could be shown by another mutant.

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Su, S., Y. Hamzavi Abedi, and A. McInerney. "M160 AQUAGENIC URTICARIA: A RARE CASE." Annals of Allergy, Asthma & Immunology 123, no. 5 (2019): S90—S91. http://dx.doi.org/10.1016/j.anai.2019.08.160.

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Chambliss, J. "M151 FACIAL DYSTONIA MASQUERADING AS ANGIOEDEMA." Annals of Allergy, Asthma & Immunology 125, no. 5 (2020): S68. http://dx.doi.org/10.1016/j.anai.2020.08.223.

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Pinto, Amelia K., Amanda M. Jamieson, David H. Raulet, and Ann B. Hill. "The Role of NKG2D Signaling in Inhibition of Cytotoxic T-Lymphocyte Lysis by the Murine Cytomegalovirus Immunoevasin m152/gp40." Journal of Virology 81, no. 22 (2007): 12564–71. http://dx.doi.org/10.1128/jvi.01328-07.

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ABSTRACT Three proteins encoded by murine cytomegalovirus (MCMV)— gp34, encoded by m04 (m04/gp34), gp48, encoded by m06 (m06/gp48), and gp40, encoded by m152 (m152/gp40)—act together to powerfully impact the ability of primed cytotoxic CD8 T lymphocytes (CTL) to kill virus-infected cells. Of these three, the impact of m152/gp40 on CTL lysis appears greater than would be expected based on its impact on cell surface major histocompatibility complex (MHC) class I. In addition to MHC class I, m152/gp40 also downregulates the RAE-1 family of NKG2D ligands, which can provide costimulation for CD8 T cells. We hypothesized that m152/gp40 may impact CTL lysis so profoundly because it inhibits both antigen presentation and NKG2D-mediated costimulation. We therefore tested the extent to which m152/gp40's ability to inhibit CTL lysis of MCMV-infected cells could be accounted for by its inhibition of NKG2D signaling. As was predictable from the results reported in the literature, NKG2D ligands were not detected by NKG2D tetramer staining of cells infected with wild-type MCMV, whereas those infected with MCMV lacking m152/gp40 displayed measurable levels of the NKG2D ligand. To determine whether NKG2D signaling contributed to the ability of CTL to lyse these cells, we used a blocking anti-NKG2D antibody. Blocking NKG2D signaling did affect the killing of MCMV-infected cells for some epitopes. However, for all epitopes, the impact of m152/gp40 on CTL lysis was much greater than the impact of inhibition of NKG2D signaling. We conclude that the downregulation of NKG2D ligands by MCMV makes only a small contribution to the impact of m152/gp40 on CTL lysis and only for a small subset of CTL.

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Zhang, Huizhi, Jifeng Liu, Yang Yue, Xiuqin Cui, and Yuezong Lian. "Load Capacity and Displacement of Recycled Concrete and Self-Insulation Block Masonry Wall." Materials 13, no. 4 (2020): 863. http://dx.doi.org/10.3390/ma13040863.

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In order to discuss the load capacity and displacement of masonry constructed with recycled concrete and self-insulation blocks, one type of 10.6 MPa compressive strength block and three kinds of mortar with M15, M10, and M5 compressive strengths are selected. The constitutive model and corresponding parameters selection of different materials in the ABAQUS numerical simulation are analyzed, and the numerical simulation analysis and experimental tests of the load capacity and displacement of masonry constructed with mortars of different strengths are carried out. The results show that masonry compression failure is controlled by the mortar or block that has the lower compressive strength. The displacement of masonry increases with the mortar compressive strength increase, and the higher mortar compressive strength is beneficial for improving the load capacity and displacement of masonry. Reasonable selection of the constitutive model and parameters will help to obtain reasonable results for the ABAQUS numerical simulation. Construction quality and loading method will affect the load capacity and displacement of the masonry. The above conclusion can provide reference for the engineering application of recycled concrete and self-insulation blocks.

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Zhao, Juanjuan, Xia Zhao, Junru Wang, Qi Gong, Xiaoxia Zhang, and Guishan Zhang. "Isolation, Identification and Characterization of Endophytic Bacterium Rhizobium oryzihabitans sp. nov., from Rice Root with Biotechnological Potential in Agriculture." Microorganisms 8, no. 4 (2020): 608. http://dx.doi.org/10.3390/microorganisms8040608.

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A flagellate, rod–shaped bacterium designated strain M15T was isolated from rice roots. Phylogenetic analysis based on the sequences of the 16S rRNA, housekeeping genes and genomes showed that the isolate belonged to the genus Rhizobium, with the highest 16S rRNA similarity to Rhizobium radiobacter LMG140T (99.64%) and Rhizobium pusense NRCPB10T (99.36%), respectively. The complete genome of the strain M15T has a 59.28% G+C content, and the highest average nucleotide identity (ANI) and DNA-DNA relatedness (DDH) values were obtained with R. radiobacter LMG140T (88.11%, 54.80%), R. pusense NRCPB10T (86.00%, 53.00%) and R. nepotum 39/7T (88.80%, 49.80%), respectively. Plant growth-promoting characteristics tests showed that the strain M15T produced siderophore, 1–aminocyclopropane–1–carboxylate (ACC) deaminase and indole-3-acetic acid (IAA) and also produced some secondary metabolites according to the analysis of the comparative genomes. Based on the data mentioned above, we proposed that the strain M15T represented a novel species of the genus Rhizobium, named Rhizobium oryzihabitans sp. nov. The type strain is M15T (=JCM 32903T = ACCC 60121T), and the strain M15T can be a novel biofertilizer Rhizobium to reduce the use of synthetic fertilizers for plant growth promotion.

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Tripathy, Sandeep K., Peter A. Keyel, Liping Yang, et al. "Continuous engagement of a self-specific activation receptor induces NK cell tolerance." Journal of Experimental Medicine 205, no. 8 (2008): 1829–41. http://dx.doi.org/10.1084/jem.20072446.

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Natural killer (NK) cell tolerance mechanisms are incompletely understood. One possibility is that they possess self-specific activation receptors that result in hyporesponsiveness unless modulated by self–major histocompatability complex (MHC)–specific inhibitory receptors. As putative self-specific activation receptors have not been well characterized, we studied a transgenic C57BL/6 mouse that ubiquitously expresses m157 (m157-Tg), which is the murine cytomegalovirus (MCMV)–encoded ligand for the Ly49H NK cell activation receptor. The transgenic mice were more susceptible to MCMV infection and were unable to reject m157-Tg bone marrow, suggesting defects in Ly49H+ NK cells. There was a reversible hyporesponsiveness of Ly49H+ NK cells that extended to Ly49H-independent stimuli. Continuous Ly49H–m157 interaction was necessary for the functional defects. Interestingly, functional defects occurred when mature wild-type NK cells were adoptively transferred to m157-Tg mice, suggesting that mature NK cells may acquire hyporesponsiveness. Importantly, NK cell tolerance caused by Ly49H–m157 interaction was similar in NK cells regardless of expression of Ly49C, an inhibitory receptor specific for a self-MHC allele in C57BL/6 mice. Thus, engagement of self-specific activation receptors in vivo induces an NK cell tolerance effect that is not affected by self-MHC–specific inhibitory receptors.

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Hanson, Laura K., Jacquelyn S. Slater, Zaruhi Karabekian, Gina Ciocco-Schmitt, and Ann E. Campbell. "Products of US22 Genes M140 and M141 Confer Efficient Replication of Murine Cytomegalovirus in Macrophages and Spleen." Journal of Virology 75, no. 14 (2001): 6292–302. http://dx.doi.org/10.1128/jvi.75.14.6292-6302.2001.

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ABSTRACT Efficient replication of murine cytomegalovirus (MCMV) in macrophages is a prerequisite for optimal growth and spread of the virus in its natural host. Simultaneous deletion of US22 gene family members M139, M140, and M141 results in impaired replication of MCMV in macrophages and mice. In this study, we characterized the proteins derived from these three genes and examined the impact of individual gene deletions on viral pathogenesis. The M139, M140, and M141 gene products were identified as early proteins that localize to both the nucleus and cytoplasm in infected cells. Gene M139 encodes two proteins, of 72 and 61 kDa, while M140 and M141 each encode a single protein of 56 (pM140) and 52 (pM141) kDa, respectively. No role for the M139 proteins in MCMV replication in macrophages or mice was determined in these studies. In contrast, deletion of either M140 or M141 resulted in impaired MCMV replication in macrophages and spleen tissue. Replication of the M140 deletion mutant was significantly more impaired than that of the virus lacking M141. Further analyses revealed that the absence of the pM140 adversely affected pM141 levels by rendering the latter protein unstable. Since the replication defect due to deletion of M140 was more profound than could be explained by the reduced half-life of pM141, pM140 must exert an additional, independent function in mediating efficient replication of MCMV in macrophages and spleen tissue. These data indicate that the US22 genes M140 and M141 function both cooperatively and independently to regulate MCMV replication in a cell type-specific manner and, thus, to influence viral pathogenesis.

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Ahagon, Asahiro. "Extensibility of Black Filled Elastomers." Rubber Chemistry and Technology 59, no. 2 (1986): 187–203. http://dx.doi.org/10.5254/1.3538192.

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Abstract Unique empirical relations are found to exist between the extension ratio at break λb and the crosslink density ν λb ∝ ν−0.75 in the absence of gross strain induced crystallization, and λb ∝ ν−0.2 in the presence of gross strain-induced crystallization. With black-filled elastomers, the modulus at 100% strain, M100, is proportional to the crosslink density over a wide temperature range. Thus, unique empirical relations exist between λb and M100 of black-filled elastomers; λb ∝ M100−0.75 in the absence of gross strain-induced crystallization, and λb ∝ M100−0.2 in the presence of gross strain-induced crystallization. The proportionality constants can be used as convenient measures of the extensibility in material evaluation on a constant modulus basis.

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Mendonça, R., A. I. Machado, R. Leal, R. Luz, and R. Gomes. "M140 HORMONAL CONTRACEPTION AND BENIGN VASCULAR TUMORS." International Journal of Gynecology & Obstetrics 119 (October 2012): S577. http://dx.doi.org/10.1016/s0020-7292(12)61334-4.

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Journal articles on the topic 'M150'

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