Journal articles on the topic 'MA JIAN ZHONG'

We experimentally demonstrate a passively Q-switched erbium-doped fiber laser (EDFL) operation by using a saturable absorber (SA) based on tungsten disulfide (WS2). By depositing WS2 thin film layer at the end of optical fiber ferrule, we fabricated a SA device. The SA is incorporated into an Erbium-doped fiber laser (EDFL) cavity to generate a Q-switching pulses train operating at 1559.8 nm. As a result, stable passively Q-switched EDFL pulses with maximum output pulse energy of 123.2 nJ, repetition rate of 104.1 kHz, and pulse width of 9.61 us are achieved when the input pump power is 142.1 mW at the wavelength of 980 nm. Full Text: PDF ReferencesC. Gao, W. Zhao, Y. Wang, S. Zhu, G. Chen, and Y. Wang, "Passive Q-switched fiber laser with SESAM in ytterbium-doped double-clad fiber", in 27th International congress on High-Speed Photography and Photonics (International Society for Optics and Photonics, 2007). CrossRef M. Ahmed, N. Ali, Z. Salleh, A. Rahman, S. Harun, M. Manaf, et al., "Q-switched erbium doped fiber laser based on single and multiple walled carbon nanotubes embedded in polyethylene oxide film as saturable absorber", Optics & Laser Technology 65, 25 (2015). CrossRef M. A. Ismail, F. Ahmad, S. W. Harun, H. Arof and H. Ahmad, "A Q-switched erbium-doped fiber laser with a graphene saturable absorber", Laser Phys. Lett. 10, 025102 (2013). CrossRef G. Sobon, J. Sotor, J. Jagiello, R. Kozinski, K. Librant, M. Zdrojek, L. Lipinska, and K. M. Abramski, "Linearly polarized, Q-switched Er-doped fiber laser based on reduced graphene oxide saturable absorber", Appl. Phys. Lett. 101, 241106 (2012). CrossRef N. H. M. Apandi, F. Ahmad, S. N. F. Zuikafly, M. H. Ibrahim, S. W. Harun, "Bismuth (III) Telluride (Bi2Te3) topological insulator embed in PVA as passive Q-switcher at 2 micron region", Photon. Lett. of Poland 8, 101 (2016). CrossRef J. Bogusławski, G. Soboń, K. Tarnowski, R. Zybała, K. Mars, A. Mikuła, K. M. Abramski and J. Sotor, "All-polarization-maintaining-fiber laser Q-switched by evanescent field interaction with Sb2Te3 saturable absorber", Optical Engineering 55, 081316 (2016). CrossRef Z. Luo, Y. Huang, M. Zhong, Y. Li, J. Wu, B. Xu, H. Xu, Z. Cai, J. Peng, and J. Weng, "1-, 1.5-, and 2-um fiber lasers Q-switched by a broadband few-layer MoS2 saturable absorber", J. Lightwave Technol. 32, 4679 (2014). CrossRef N. N. Razak, A. A. Latiff, Z. Zakaria and S. W. Harun, "Q-switched Erbium-doped Fiber Laser with a Black Phosphorus Saturable Absorber", Photon. Lett. of Poland 9, 72 (2017). CrossRef D. Mao, Y. Wang, C. Ma, L. Han, B. Jiang, X. Gan, S. Hua, W. Zhang, T. Mei, and J. Zhao, "WS2 mode-locked ultrafast fiber laser", Sci Rep 5, 7965 (2015). CrossRef K. Wu, X. Zhang, J. Wang, X. Li, and J. Chen, "WS2 as a saturable absorber for ultrafast photonic applications of mode-locked and Q-switched lasers", Optics Express 23, 11453 (2015). CrossRef K. Lau, A. Latif, M. A. Bakar, F. Muhammad, M. Omar, and M. Mahdi, "Mechanically deposited tungsten disulfide saturable absorber for low-threshold Q-switched erbium-doped fiber laser", Applied Physics B 123, 221 (2017). CrossRef H. Chen, Y. Chen, J. Yin, X. Zhang, T. Guo, and P. Yan, "High-damage-resistant tungsten disulfide saturable absorber mirror for passively Q-switched fiber laser", Optics Express 24, 16287 (2016). CrossRef J. Lin, K. Yan, Y. Zhou, L. Xu, C. Gu, and Q. Zhan, "Tungsten disulphide based all fiber Q-switching cylindrical-vector beam generation", Applied Physics Letters 107, 191108 (2015). CrossRef H. Chen, Y. Chen, J. Yin, X. Zhang, T. Guo, and P. Yan, "High-damage-resistant tungsten disulfide saturable absorber mirror for passively Q-switched fiber laser", Optics Express 24, 16287 (2016). CrossRef K. Mohamed, B. Hamida, S. Khan, L. Hussein, M. Ahmat, E. Ismail, N. Kadir, A. Latif, S. Harun, "Q-switched erbium-doped fibre laser based on molybdenum disulfide and tungsten disulfide as saturable absorbers," Ukrainian Journal of Physical Optics, 18 (2017). CrossRef

Objectives X-linked hypophosphataemic rickets (XLHR) is a disease of impaired bone mineralization characterized by hypophosphataemia caused by renal phosphate wasting. The main clinical manifestations of the disorder are O-shaped legs, X-shaped legs, delayed growth, and bone pain. XLHR is the most common inheritable form of rickets, with an incidence of 1/20 000 in humans. It accounts for approximately 80% of familial cases of hypophosphataemia and serves as the prototype of defective tubular phosphate (PO43+) transport, due to extra renal defects resulting in unregulated FGF23 activity. XLHR is caused by loss-of-function mutations in the PHEX gene. The aim of this research was to identify the genetic defect responsible for familial hypophosphataemic rickets in a four-generation Chinese Han pedigree and to analyze the function of this mutation. Methods The genome DNA samples of all members in the pedigree were extracted from whole blood. We sequenced all exons of the PHEX and FGF23 genes, as well as the adjacent splice site sequence with Sanger sequencing. Next, we analyzed the de novo mutation c.1692 del A of the PHEX gene with an online digital service and investigated the mutant PHEX with SWISS-MODEL, immunofluorescence, and protein stability detection. Results Through Sanger sequencing, we found a de novo mutation, c.1692 del A, in exon 16 of the PHEX gene in this pedigree. This mutation can make the PHEX protein become unstable and decay rapidly, which results in familial XLHR. Conclusion We have found a de novo loss-of-function mutation, c.1692 del A, in exon 16 of the PHEX gene that can cause XLHR. Cite this article: J. Huang, X. Bao, W. Xia, L. Zhu, J. Zhang, J. Ma, N. Jiang, J. Yang, Q. Chen, T. Jing, J. Liu, D. Ma, G. Xu. Functional analysis of a de novo mutation c.1692 del A of the PHEX gene in a Chinese family with X-linked hypophosphataemic rickets. Bone Joint Res 2019;8:405–413. DOI: 10.1302/2046-3758.88.BJR-2018-0276.R1.

According to (Coetzee and Pauw 2013), the retention of capable staff of nursing is crucial for leaders of nursing because of identifying the consequences of shortage in nursing staff. However, the skills and ability of leaders affect reactions to the situations (Coetzee and Pauw 2013). The deficiency of nursing staff relies on many components of the delivery of healthcare. There is a negative influence on the nursing staff's high turnover on patients, finance, and outcomes of hospitals (Mxenge, Dywill, et al., 2014; Langove and Isha, 2017). Recruiting and training of nursing have a monetary impact which is evaded by a good number of healthcare corporations. The standard cost of substituting a nurse is estimated in the USA from 42,000 USD to 64,000 USD (Galati and Moessner 2013). Zhang, Jiang et al. (2017) stated that the organization of healthcare is always changing and the global turnover of nurses is high. According to the Economic Survey of Pakistan (2012), there is an unavailability of 60,000 staff of nursing in Pakistan (Rehman, Jingdong, et al. 2019). Also, Pakistan is one of the 57 countries that have a severe deficiency of nursing staff under the standard of WHO to provide needed healthcare (McGuire 2016). Therefore, organizations of healthcare consistently struggle to retain nursing staff to deal with the issues of nursing scarcity (Ponte and Sturgeon 2014). This research study would provide a more effective understanding of the backgrounds of turnover of employees if job complexity, the volume of job information that a person holds at the selection time, and the scenario of the labor market were carefully considered. For this reason, these issues are taken as research limitations and more study need to be done to address these problems (Lu Lu, Lu, Gursoy, & Neale, 2016; Shaozhuang Ma, Silva, Callan, & Trigo, 2016; Mamoona Rasheed, Iqbal, & Mustafa, 2018) Various earlier researches on productive workplace atmosphere which has focused on several positive results such as performance, employees' well-being, and behavior of organizational citizenship (Lonsdale, 2016; Zhang, Gong, et al., 2017; Evans and Dobrosielska 2019). Keywords: Emotional intelligence, Organizational Commitments, Turnover Intention, Pakistani Healthcare Sector

Background:Ankylosing spondylitis (AS) is a chronic inflammatory disease that mainly affects the sacroiliac joints and the spine, resulting in decline in quality of life[1,2]. Poor QoL is significantly related to high disease activity[3]. However, there is no systematic report on which prognosis indicators are affected by disease activity in AS patients.Objectives:This study aimed to evaluate the patient-reported outcome measures and health-related quality of life (HR-QoL) in AS patients defined on the basis of the Bath Spondylitis Ankylosing Disease Activity Index (BASDAI).Methods:204 AS patients were involved in this study. A serious of questionnaires were used to overall assess AS patients, which include: Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Metrology Index (BASMI), Bath Ankylosing Spondylitis Functional Index (BASFI), the 10 cm Visual Analog Scale (VAS), the Self-Rating Anxiety Scale (SAS), the Self-Rating Depression Scale (SDS), the Pittsburgh Sleep Quality Index (PSQI), the Health Assessment Questionnaire-Disability Index (HAQ-DI), the Fatigue Severity Scale(FSS) and the Short Form 36 Health Survey (SF-36). Independent samples t-test, Mann–Whitney U-test, Chi-square analysis and Pearson /Spearman correlation were used to analyze the data.Results:The results demonstrated 31.4% AS patients were in active disease activity stage. Active AS patients were older, unemployed, and had less exercise therapy than stable AS patients. Besides, AS patients with active disease activity presented more severe pain(P<0.001), poor physical function(P<0.001) and spinal mobility(P<0.001). They were more anxious(P<0.001), depressed(P<0.001) and had more sleep disturbance(P=0.001). Compared with active AS patients, stable AS patients had more leukocytes(P=0.040), lymphocytes(P=0.002), erythrocytes(P=0.001) and hemoglobin(P<0.001). Active disease activity had a significant impact on all dimensions of quality of life in AS patients(P<0.001).Conclusion:These findings suggested that medical personnel should pay more attention to active AS patients and make effective interventions to improve quality of life.References:[1]Exarchou S, Lindstrom U, Askling J, Eriksson JK, Forsblad-d’Elia H, Neovius M, Turesson C, Kristensen LE, Jacobsson LT (2015) The prevalence of clinically diagnosed ankylosing spondylitis and its clinical manifestations: a nationwide register study. Arthritis research & therapy 17:118. doi:10.1186/s13075-015-0627-0[2]Qian Q, Xu X, He H, Ji H, Zhang H, Ding Y, Dai SM, Zou Y, Zhu Q, Yang C, Ye S, Jiang L, Tang JP, Tong Q, He D, Zhao D, Li Y, Ma Y, Zhou J, Yuan Z, Zhang J, Jin L, Zhou X, Reveille JD, Zou H, Wang J (2017) Clinical patterns and characteristics of ankylosing spondylitis in China. Clinical rheumatology 36 (7):1561-1568. doi:10.1007/s10067-017-3660-3[3]Huang JC, Qian BP, Qiu Y, Wang B, Yu Y, Zhu ZZ, Hu J, Qu Z (2017) Quality of life and correlation with clinical and radiographic variables in patients with ankylosing spondylitis: a retrospective case series study. BMC musculoskeletal disorders 18 (1):352. doi:10.1186/s12891-017-1711-1Acknowledgments:Thanks to all the authors for their efforts and thanks to all members of the Department of Rheumatology of Affiliated Hospital of Nantong University for their helpfulness in the acquisition of data.Disclosure of Interests:None declared

About one third of the world's land surface is covered with arid and semi-arid areas. It is predicted that global warming will increase desertification by 17% before 2050. At present, desertification is making approximately 12 million hectares every year useless for cultivation and grazing worldwide. Over 250 million people and one third of the earth's land surface are directly threatened by desertification (Diallo 2003). China is one of several countries severely affected by desertification; almost 90% of natural grassland has been affected to differing degrees (Lu & Yang 2001; State Environmental Protection Administration of the People's Republic of China 2002). The land desertification rate in China was 1560 km2 yr−1 in the 1970s. This rate had increased to 2100 km2 yr−1 by the 1980s, and was 2460 km2 yr−1 by 1995 and 3436 km2 yr−1 in 1999 (Zhu et al. 1999). Areas that have shown increased desertification are derived from degraded grassland or cultivated land (Zhang & Cheng 2001). One very serious direct consequence of grassland degradation is thought to be the frequent occurrence of sandstorms. Whereas China was hit by almost 70 sandstorms over the past century (Qing 2002), with an average frequency of one sandstorm every three years in the 1940s, this had increased to one every two years by the 1960s. By the 1990s, the sandstorms in north China took place several times a year and this increased further to 12 in 2000 and 18 in 2001 (Jiang 2002a). The frequency of sandstorms in north China appears to be a direct consequence of grassland degradation. Taking Hunshandak Sandland in Inner Mongolia as an example (Fig. 1), the proportion of sand dunes that are shifting rose from 2.3% in the 1950s to 50% in the 1990s, while available grasslands declined by some 40% between the 1950s and the 1990s. The economic cost of these sandstorms has prompted the Chinese government to commit substantial funds to meet this loss, but the degradation is ongoing in the area and the living standards of local people are still low (Liu et al. 2003). It is opportune to adjust strategies to reach two objectives simultaneously, namely to restore the degraded grassland, and improve the living conditions of local people. To illustrate this, we focus on Zhenglan Banner (county), which is representative of the whole Hunshandak Sandland in terms of climate (Ma et al. 1998), economy and ecology (Fig. 1). Zhenglan Banner has a total area of 100 600 km2, a human population of 78 730 and stock raising is the dominant industry, the average income per person per year being US$ 225 (Bureau of Stock Raising in Zhenglan Banner 2002).

Two Permian-Triassic boundary (PTB) successions, Lung Cam in Vietnam, and Lukač in Slovenia, have been sampled for high-resolution magnetic susceptibility, stable isotope and elemental chemistry, and biostratigraphic analyses. These successions are located on the eastern (Lung Cam section) and western margins (Lukač section) of the Paleo-Tethys Ocean during PTB time. Lung Cam, lying along the eastern margin of the Paleo-Tethys Ocean provides an excellent proxy for correlation back to the GSSP and out to other Paleo-Tethyan successions. This proxy is tested herein by correlating the Lung Cam section in Vietnam to the Lukač section in Slovenia, which was deposited along the western margin of the Paleo-Tethys Ocean during the PTB interval. It is shown herein that both the Lung Cam and Lukač sections can be correlated and exhibit similar characteristics through the PTB interval. Using time-series analysis of magnetic susceptibility data, high-resolution ages are obtained for both successions, thus allowing relative ages, relative to the PTB age at ~252 Ma, to be assigned. Evaluation of climate variability along the western and eastern margins of the Paleo-Tethys Ocean through the PTB interval, using d18O values indicates generally cooler climate in the west, below the PTB, changing to generally warmer climates above the boundary. A unique Black Carbon layer (elemental carbon present by agglutinated foraminifers in their test) below the boundary exhibits colder temperatures in the eastern and warmer temperatures in the western Paleo-Tethys Ocean.ReferencesBalsam W., Arimoto R., Ji J., Shen Z, 2007. Aeolian dust in sediment: a re-examination of methods for identification and dispersal assessed by diffuse reflectance spectrophotometry. International Journal of Environment and Health, 1, 374-402.Balsam W.L., Otto-Bliesner B.L., Deaton B.C., 1995. 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Background:As the standard markers of systemic inflammation in autoimmune diseases erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are usually used, but in recent years there have been conflicting results about the potential significance of neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR).Objectives:Our aim was to investigate the correlation of NLR and PLR with disease activity in patients with systemic lupus erythematosus (SLE).Methods:The study involved 160 patients with SLE (145 women and 15 men), hospitalized in the Clinic of Rheumatology, Institute „Niška Banja“, aged on the average 46.34 ± 10.82 years and with average disease duration of 9.76 ± 8.27 years, in whom the diagnosis was established based on the revised ACR criteria from 1997. In addition to clinical examination and supplementary tests, their disease activity was assessed using theSystemic Lupus Erythematosus Disease Activity Index(SLEDAI), together with determination of NLR and PLR.Results:In SLE patients, there was a positive correlation of NLR with ESR (r=0.212; p=0.010), anti-dsDNA antibodies (r=0.185; p=0.025), and PLR (r=0.601; p<0.001), as well as a negative correlation with complement component 3 (C3) (r=-0.264; p=0.003). Further, there was a positive correlation of PLR with ESR (r=0.329; p<0.001), CRP (r=0.249; p=0.003), anti-dsDNA antibodies (r=0.280; p=0.001), anti-nucleosome antibodies (r=0.263; p=0.026), and values of urinary chemoattractant protein-1 (MCP1) (r=0.263; p=0.043), as well as a negative correlation with C3 (r=-0.276; p=0.002). Our univariate analysis demonstrated that not only the values of ESR, CRP, C3, anti-dsDNA, anti-nucleosome, anti-C1q antibodies, serum and urinary MCP1 (p<0.001) were statistically significantly associated with SLEDAI, but also the NLR (p<0.001) and PLR (p<0.001). Using the method of standard multiple regression analysis, we examined the impact of the above parameters on SLEDAI. The examined model accounted for 21.7% of variance in activity index (corrected r2=0.217, F=2.525, p=0.017). As the statistically significant risk factors, ESR (Beta=0.394, p=0.020) and serum MCP1 (Beta=0.325, p=0.043) stood out.Conclusion:NLR and PLR, as hematological parameters available in everyday clinical work, can be significant for disease activity assessment in SLE patients.References:[1]Gasparyan AY, Ayvazyan L, Mukanova U, Yessirkepov M, Kitas GD. The Platelet-to-Lymphocyte Ratio as an Inflammatory Marker in Rheumatic Diseases. Ann Lab Med. 2019;39(4):345-57.[2]Yu H, Jiang L, Yao L, Gan C, Han X, Liu R, Su N. Predictive value of the neutrophil-to-lymphocyte ratio and hemoglobin in systemic lupus erythematosus. Exp Ther Med. 2018;16(2):1547-53.[3]Wu Y, Chen Y, Yang X, Chen L, Yang Y. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were associated with disease activity in patients with systemic lupus erythematosus. Int Immunopharmacol. 2016;36:94-9.[4]Yolbas S, Yildirim A, Gozel N, Uz B, Koca SS. Hematological Indices May Be Useful in the Diagnosis of Systemic Lupus Erythematosus and in Determining Disease Activity in Behcet’s Disease. Med Princ Pract. 2016;25(6):510–6.[5]Qin B, Ma N, Tang Q, Wei T, Yang M, Fu H, Hu Z, Liang Y, Yang Z, Zhong R. Neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were useful markers in assessment of inflammatory response and disease activity in SLE patients. Mod Rheumatol. 2016;26(3):372–6.Disclosure of Interests:None declared

Introdução: A candidemia é uma das infecções nasocomiais mais frequentes a nível mundial e apresenta diferentes espécies de Candida envolvidas com o desenvolvimento dessa patologia. Objetivo: Este estudo analisou os aspectos epidemiológicos e as diferentes espécies de Candida associadas à candidemia. Material e Métodos: Uma revisão de literatura foi realizada, através da leitura de artigos científicos publicados nas bases de dados Pubmed e Scielo nos últimos cinco anos. Utilizou-se as seguintes combinações de descritores: Candidemia, Candidemia e Prevalência, Candidemia e Incidência, Candidemia e Candida. Resultados: A candidemia é a infecção fúngica mais hostil atualmente encontrada e prevalente nas populações estudadas. A população mais afetada são os recém-nascidos. Apresenta altas taxas de mortalidade e disseminação em várias partes do mundo. A nutrição parenteral, a administração de antibióticos de amplo espectro, hospitalização prolongada, cirurgia prévia e colonização por Candida sp são os principais fatores de risco relatados na literatura. Múltiplas espécies fúngicas estão associadas a essa condição, porém C. albicans é a mais predominante, seguida por C. parapsilosis e C. tropicalis. Conclusões: A Candidemia é uma patologia prevalente e apresenta alta incidência e morbimortalidade nas populações estudadas das diferentes partes do mundo. C. albicans é a espécie mais associada, seguida por C. parapsilosis e C. tropicalis.
 Descritores: Candidemia; Prevalência; Incidência; Candida.
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A preliminary study to determine the group of compound contained in the ethanolic extract of mahagony (Swietenia mahagoni L. Jacq.) seeds and its inhibitory activity to a-glucosidase enzyme has been done. The information from this study will be used in the further investigation about the specific constituents related to the bioactivity. The seed was grounded and then extracted with ethanol by maceration technique. The crude extract was separated with liquid-liquid extraction by using n-hexane, ethyl acetate, and methanol as the solvents. The best eluent for isolation, chloroform:ethanol (1:1), was determined by thin layer chromatography while alumina as stationary phase. The isolation step with column chromatography gave two types of isolates, yellow and colorless isolate. In order to get information about the compound, the crude extract was subjected to phytochemical assignment and the isolate with the better activity was analyzed by infrared spectroscopy. The inhibitory activity for the yellow isolate with IC50 as 19.345 ppm was better than the colorless isolate. Therefore, the IR spectroscopy assay was subjected to the yellow isolate. Based on the comparison IR spectra with literatures, it has suggested that the yellow isolate contains tetranortriterpenoid or limonoid group.Keywords: Swietenia mahagoni L. Jacq., diabetes type 2, a-glucosidase, tetranortriterpenoidREFERENCE World Health Organization. Global report on diabetes. http://www.who.int. Accessed on 18 July 2017.Kementerian Kesehatan Republik Indonesia. 2014. Situasi dan analisis diabetes. Jakarta: Pusat Data dan Informasi Kemenkes RI.Dutta, M., Raychaudhuri, U., Chakroborty, R., and Maji, D. 2011. Role of diet and plants on diabetic patients - a critical appraisal. Science and Culture. 77 (3–4).Eid, A.M.M., Elmarzugi, N.A., and El-Enshasy, H.A. 2013. A Review on the phytopharmacological effect of Swietenia macrophylla, Int J Pharm Pharm Sci. 5 (3): 47-53.Bera, T.K., Chatterjee, K., Jana, K., Ali, K.M., De, D., Maiti, M., and Ghosh, D. 2012. Antihyperglycemic and antioxidative effect of hydro-methanolic (2:3) extract of the seed of Swietenia mahagoni (L.) Jacq. in streptozotocin-induced diabetic male albino rat: an approach through pancreas. Genomic Medicine, Biomarkers, and Health Sciences. 4: 107-117.Li, D.D, Chen, J.H, Chen, Q, Li, G.W, Chen, J, and Yue, J.M. 2005. Swietenia mahagony extract shows agonistic activity to PPAR-γ and gives ameliorative effects on diabetic db/db mice. Acta Pharmacol Sinica. 26 (2): 220-222.Sathish, R., Natarajan, K., and Selvakumar, S. 2010. Antidiabetic activity of Swietenia mahagoni seed powder in alloxan induced diabetic mice. Research J. Pharmacology and Pharmacodynamics. 2(4): 296-299.Wresdiyati, T., Sa’diah, S., and Winarto, A., Febriyani, V. 2015. Alpha-glucosidase inhibition and hypoglycemic activities of Sweitenia mahagoni seed extract. HAYATI Journal of Biosciences. 22 (2): 73-78.Sukardiman, Riza, N.F., Rakhmawati, Studiawan, H., Mulja, H.S., and Rahman, A. 2013. Hypoglycemic activity of 96% ethanolic extract of Andrographis paniculata Nees. and Swietenia mahagoni Jacq. combination, E-Journal Planta Husada,. 1.Masitha, M. 2011. Skrining aktivitas penghambatan enzim α-glukosidase dan penapisan fitokimia dari beberapa tanaman obat yang digunakan sebagai antidiabetes di indonesia. Skripsi. FMIPA UI.Aliyan, A.H. 2012. Uji penghambatan aktivitas alfa-glukosidase dan identifikasi golongan senyawa kimia dari fraksi aktif ekstrak biji mahoni (Swietenia macrophylla King). Skripsi. FMIPA UI.Ibrahim, M.A., Koorbanally, N.A., and Islam, M.S. 2014. Antioxidative activity and inhibition of key enzymes linked to type-2 diabetes (a-glucosidase and a-amylase) by Khaya senegalensis. Acta Pharm. 64: 311–324.Harborne, J. B. 1984. Phytochemical methods: a guide to modern techniques of plant analysis. New York: Chapman and Hall.Kadota, S., Marpaung, L., Tohru, K., and Ekimoto, H. 1990. Constituents of the seeds of Switenia mahagoni JACQ. I. isolation, structures, and 1H- and 13C-nuclear magnetic resonance signal assignments of new tetranorterpenoids related to swietenine and swietenolide. Che. Pharm. Bull. 38(3): 639–651.Rahman, A. K. M. S., Chowdhury, A. K. A., Ali, H.A., Raihan, S.Z, Ali, M.S., Nahar, L., and Sarker, S.D. 2009. Antibacterial activity of two limonoids from Swietenia mahagoni against multiple-drug-resistant (MDR) bacterial strains. J Nat Med. 63: 41–45.Yadav, L.D.S. 2005. Organic spectroscopy. Allahabad: Kluwer Academic Publishers.Dewanjee, S., Maiti, A., Das, A.K., Mandal, S.C., and Dey, S.P. 2009. Swietenine: a potential oral hypoglycemic from swietenia macrophylla seed. Fitoterapia. 80: 249–251.Maiti, A., Dewanjee, S., and Sahu, R. 2009. Isolation of hypoglycemic phytoconstituent from Swietenia macrophylla Seeds, Phytother. Res. 23: 1731–1733.Marliana, S.D., Suryanti, V., and Suyono. 2005. Skrining fitokimia dan analisis kromatografi lapis tipis komponen kimia buah labu siam (Sechium edule Jacq. Swartz.) dalam ekstrak etanol, Biofarmasi. 3 (1): 26-31.Nurhayati, Siadi, K., and Harjono. 2012. Pengaruh konsentrasi natrium benzoat dan lama penyimpanan pada kadar fenolat total pasta tomat, Indo. J. Chem. Sci. Vol. 1 (2): 158-163.Siadi, K. 2012. Ekstrak bungkil biji jarak pagar (Jatropha curcas) sebagai biopestisida yang efektif dengan penambahan larutan NaCl. Jurnal MIPA. 35 (1): 80-81.Klein, D.R. 2012. Organic chemistry. New Jersey: John Wiley & Sons.Pavia, D.L., Lampman, G.M., and Kriz, G.S. 2001. Introduction to spectroscopy. London: Thomson Learning.Minaeva, V.A., Minaev, B.F., Baryshnikov, G.V., Romeyko, O.M., and Pittelkow, M. 2013. The FTIR spectra of substituted tetraoxa[8]circulenes and their assignments based on DFT calculations, Vibrational Spectroscopy. 65: 147–158.Mootoo, B.S., Ali, A, Motilal, R, Pingal, R, Ramlal, A, Khan, A, Reynolds, W.F, and McLean, S. 1999. Limonoids from Swietenia macrophylla and S. aubrevilleana. J. Nat. Prod. 62: 1514-1517.Lin, B.D., Yuan, T., Zhang, C.R., Dong, L., Zhang, B., Wu, Y., and Yue, J.M. 2009. Structurally diverse limonoids from the fruits of Swietenia mahagoni. J. Nat. Prod. 72: 2084–2090.Cheng, Y.B., Chien, Y.T., Lee, J.C., Tseng, C.K., Wang, H.C., Lo, W., Wu, Y.H., Wang, S.Y., Wu, Y.C., and Chang, F.R. 2014. Limonoids from the seeds of Swietenia macrophylla with inhibitory activity against dengue virus 2. J. Nat. Prod. dx.doi.org/10.1021/np5002829.Zhang, W.M., Liu, J.Q., Deng, Y.Y., Xia, J.J., Zhang, R.N., Li, Z.R., and Qiu, M.H. 2014. Diterpenoids and limonoids from the leaves and twigs of Swietenia mahagoni. Nat. Prod. Bioprospect. 4:53–57.Ma, Y.Q., Jiang, K., Deng, Y., Guo, L., Wan, Y.Q., and Tan, C.H. 2017. Mexicanolide-type limonoids from the seeds of Swietenia macrophylla, Journal of Asian Natural Products Research, DOI: 10.1080/1028-6020.2017.1335715.Zang, Y., amd Xu, H. 2017. Recent progress in the chemistry and biology of limonoids. RSC Adv. 7: 35191–35220.Tan, Q.G., and Luo, X.D. 2011. Meliaceous limonoids: chemistry and biological activities. Chem. Rev., 111, 7437–7522.Fang, X., Di, Y. T, and Hao, X. J. 2011. The advances in the limonoid chemistry of the Meliaceae family. Current Organic Chemistry. 15: 1363-1391.Taylor, D. A. H. The chemistry of the limonoids from meliaceae. https://link.spri-nger.com/book-series/126. Accessed on 21 July 2017.Zang, Y., amd Xu, H. 2017. Recent progress in the chemistry and biology of limonoids. RSC Adv. 7: 35191–35220.

Исследованы структурные особенности нанокомпозитов, полученных при лазерном облучении водно-белковых сред с одностенными углеродными нанотрубками (ОУНТ), электродуговым (ОУНТI) и газофазным методами (ОУНТII). С помощью спектроскопии комбинационного рассеяния нанокомпозитов определен нековалентный характер взаимодействия нанотрубок с молекулами белков. Белковая составляющая в нанокомпозитах подверглась необратимой денатурации и может выступать в качестве связующего биосовместимого материала, который является источником аминокислот для биологических тканей при имплантации нанокомпозитов в организм. Образцы, изготовленные из ОУНТI, с меньшим диаметром и длиной имели наиболее однородную структуру. При увеличении концентрации от 0.01 до 0.1 % происходило увеличение среднего размерамикропор от 45 до 85 мкм и пористости образца в общем с 46 до 58 %. При этом доля открытых пор для двух типов концентраций ОУНТI составила 2 % от общего объема композита. В нанокомпозитах на основе ОУНТI показано наличие мезопор. Увеличение концентрации нанотрубок привело к уменьшению удельных значений поверхности и объема пор образца. Исследованные нанокомпозиты могут использоваться в качестве тканеинженерных матриц для восстановления объемных дефектов биологических тканей
 
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В данной работе продемонстрирована возможность применения ИК-микроспектроскопии для многомерной визуализации и анализа интеграции с нативными твердыми тканями зуба человека нового поколения биомиметических материалов, воспроизводящих минералорганический комплекс эмали и дентина.На основе ИК-картирования интенсивности конкретной функциональной молекулярной группы с использованием синхротронного излучения найдены и визуализированы характеристические особенности биомиметического переходного слоя в межфазной области эмаль/стоматологический материал и определено расположение функциональных групп, отвечающих процессам интеграции биомиметического композита
 
 
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This study aim to attempt mapping out the Land Use or Land Cover (LULC) status of Regional Project Coordination Committee (RPCC) between 2009-2019 with a view of detecting the land consumption rate and the changes that has taken place using RS and GIS techniques; serving as a precursor to the further study on urban induced variations or change in weather pattern of the cityn Rangpur City Corporation(RCC) is the main administrative functional area for both of Rangpur City and Rangpur division and experiencing a rapid changes in the field of urban sprawl, cultural and physical landscape,city growth. These agents of Land use or Land cover (LULC) varieties are responsible for multi-dimensional problems such as traffic congestion, waterlogging, and solid waste disposal, loss of agricultural land. In this regard, this study fulfills LULC changes by using Geographical Information Systems (GIS) and Remote Sensing (RS) as well as field survey was conducted for the measurement of change detection. The sources of data were Landsat 7 ETM and landsat 8 OLI/TIRS of both C1 level 1. Then after correcting the data, geometrically and radiometrically change detection and combined classification (supervised & unsupervised) were used. The study finds LULC changes built-up area, water source, agricultural land, bare soil in a change of percentage is 17.23, 2.58, -9.94, -10.19 respectively between 2009 and 2019. Among these changes, bare soil is changed to a great extent, which indicates the expansion of urban areas is utilizing the land to a proper extent.
 Keywords: Urban expansion; land use; land cover; remote sensing; geographic information system (GIS); Rangpur City Corporation(RCC).
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В последние годы высокими темпами проводятся исследования, связанные с поиском и изучением механизма действия новых и применяющихся в медицине ноотропных средств. Представляют интерес исследования, связанные с поиском новых комбинированных лекарственных средств ноотропного действия на основе субстанций D-гамма-пантотената кальция и янтарной кислоты, обладающих нейрометаболическими, атигипоксическими и адаптогенными свойствами. Целью настоящего исследования являлись разработка и обоснование оптимальных составов и технологий изготовления таблеток, обладающих ноотропным действием, и стандартизация предложенных лекарственных форм, содержащих пантогам и янтарную кислоту.Способ приготовления таблеточной смеси: все компоненты отвешивали в необходимом количестве, в ступку вносили пантогам, затем янтарную кислоту и растирали до однородного белого порошка. Прессование таблеток проводили на ручном прессе при давлении 120 мн/м2. Нанесение покрытия осуществлялось на лабораторной установке псевдоожиженного слоя с одной форсункой в перфорированном барабане объёмом 1000 мл. Полученные таблетки оценивали согласно требованиям по Государственной Фармакопее XIII, XIV. Сравнение таблеток пантогама сянтарной кислотой, полученных методом прямого прессования и влажного гранулирования, показало, что метод прямого прессования позволяет получать таблетки с хорошими физико-механическими показателями и биодоступностью. Для количественного определения пантогама в таблетках разработаны методики, основанные на кислотно-основном титровании, спектрофотометрическом определении. Проведена валидация методики количественного определения янтарной кислоты в лекарственных формах.На основании изучения физико-химических, технологических свойств субстанций и вспомогательных веществ обоснованы и разработаны составы и технология получения таблеток, содержащих пантогам и янтарную кислоту. Установлено, что при совместном присутствии пантогама и янтарной кислоты в таблетках происходят твердофазные взаимодействия. Разработаны методы качественного и количественного анализа лекарственных форм, содержащих пантогам, янтарную кислоту, основанные на комплексонометрическом титровании и высокоэффективной жидкостной хроматографии. Процедура валидации определения янтарной кислоты методом высокоэффективнойжидкостной хроматографии в разработанных лекарственных формах показала обоснованность предложенной методики.
 
 
 
 
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The achievement of children's quality of life is undoubtedly linked to the development of positive habits that will continue to be practiced in future lives. This can be done by developing awareness and behavior of a balanced clean and healthy lifestyle. The purpose of this study was to determine the increase in the PHBS ability of children. Various efforts have been made so that children with intellectual disabilities can maintain their cleanliness. The efforts made by the teacher are still not maximal so that the delivery of information about PHBS must be completed by another method, namely demonstration. This research was conducted at SDLB 127710 Pematangsiantar5 with an action research method that refers to the Kurt Lewin model. Data collection techniques used purposive sampling and data analysis with the Wilcoxon test. The results showed an increase in understanding of the PHBS of children with intellectual disabilities able to learn SDLB 127710 Pematangsiantar through the demonstration method. This is evidenced by the increase in the score, where the initial assessment was obtained (59%), while in the first cycle, the average score was good (69.9%). In short, the understanding of children with intellectual disabilities being able to learn about PHBS is increased by using the demonstration method. 
 Keywords: Intellectual Disability Children, PHBS program, Demonstration methods
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Rapid urbanization rates impact significantly on the nature of Land Cover patterns of the environment, which has been evident in the depletion of vegetal reserves and in general modifying the human climatic systems (Henderson, et al., 2017; Kumar, Masago, Mishra, & Fukushi, 2018; Luo and Lau, 2017). This study explores remote sensing classification technique and other auxiliary data to determine LULCC for a period of 50 years (1967-2016). The LULCC types identified were quantitatively evaluated using the change detection approach from results of maximum likelihood classification algorithm in GIS. Accuracy assessment results were evaluated and found to be between 56 to 98 percent of the LULC classification. The change detection analysis revealed change in the LULC types in Minna from 1976 to 2016. Built-up area increases from 74.82ha in 1976 to 116.58ha in 2016. Farmlands increased from 2.23 ha to 46.45ha and bared surface increases from 120.00ha to 161.31ha between 1976 to 2016 resulting to decline in vegetation, water body, and wetlands. The Decade of rapid urbanization was found to coincide with the period of increased Public Private Partnership Agreement (PPPA). Increase in farmlands was due to the adoption of urban agriculture which has influence on food security and the environmental sustainability. The observed increase in built up areas, farmlands and bare surfaces has substantially led to reduction in vegetation and water bodies. The oscillatory nature of water bodies LULCC which was not particularly consistent with the rates of urbanization also suggests that beyond the urbanization process, other factors may influence the LULCC of water bodies in urban settlements.
 Keywords: Minna, Niger State, Remote Sensing, Land Surface Characteristics
 
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Abstract This paper reports the first academic research on the collection of Yan Xinhou (1838–1906), a prominent gentry–merchant from the second half of the nineteenth century. It presents the Yan collection, now housed at the Herbert F. Johnson Museum of Art at Cornell University, and tells a fascinating story of the Yan family and how their collection came to the United States during the early twentieth century. More importantly, it provides a starting point for future explorations of the taste, collecting practices and social relations of the late Qing merchants. The collection contains thirty-two works of Ming and Qing dynasty painting and calligraphy, including calligraphy items by Zhang Ruitu (1570–1641), Jiang Chenying (1628–1699) and Qian Bojiong (1738–1812); paintings by Wang Shimin (1592–1680), Xiao Yuncong (1596–1673), Wang Wu (1632-1690), Ma Quan (active 1800s), Shangguan Zhou (1665–c.1749), Zheng Xie (1693–1765), Hua Yan (1682–1756), Xi Gang (1746–1803), Pan Simu (1756–after 1843), Zhao Wei (1746–1825), Qian Du (1764–1845), Gai Qi (1773–1828) and Wu Xizai (1799–1870).

Graphene-based composites have received a great deal of attention in recent year because the presence of graphene can enhance the conductivity, strength of bulk materials and help create composites with superior qualities. Moreover, the incorporation of metal oxide nanoparticles such as Fe3O4 can improve the catalytic efficiency of composite material. In this work, we have synthesized a composite material with the combination of reduced graphene oxide (rGO), and Fe3O4 modified tissue-paper (mGO-PP) via a simple hydrothermal method, which improved the removal efficiency of the of methylene blue (MB) in water. MB blue is used as the model of contaminant to evaluate the catalytic efficiency of synthesized material by using a Fenton-like reaction. The obtained materials were characterized by SEM, XRD. The removal of materials with methylene blue is investigated by UV-VIS spectroscopy, and the result shows that mGO-PP composite is the potential composite for the color removed which has the removal efficiency reaching 65% in acetate buffer pH = 3 with the optimal time is 7 h.
 Keywords
 Graphene-based composite, methylene blue, Fenton-like reaction.
 References
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Red bayberry (Myrica rubra (Lour.) Siebold & Zucc.), small trees, evergreen, dioecious, natively grows in evergreen broad-leaved forests at elevation of 1580-1875 m a.s.l., and can survive in low nutrient soil at Cao Ma Po commune, Quan Ba district, Ha Giang province. Some data on morphology, phenology, population structure, natural regeneration and distribution of Red baybery, climatic characteristics, physical and chemical properties of soil, and vegetation structure of forests having Myrica rubra occurrence are presented in this paper.
 Keywords
 Red bayberry, Myrica rubra, biology, ecology, conservation, Ha Giang, Vietnam
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 Object segmentation is an important task which is widely employed in many computer vision applications such as object detection, tracking, recognition, and retrieval. It can be seen as a two-phase process: object detection and segmentation. Object segmentation becomes more challenging in case there is no prior knowledge about the object in the scene. In such conditions, visual attention analysis via saliency mapping may offer a mean to predict the object location by using visual contrast, local or global, to identify regions that draw strong attention in the image. However, in such situations as clutter background, highly varied object surface, or shadow, regular and salient object segmentation approaches based on a single image feature such as color or brightness have shown to be insufficient for the task. This work proposes a new salient object segmentation method which uses a depth map obtained from the input image for enhancing the accuracy of saliency mapping. A deep learning-based method is employed for depth map estimation. Our experiments showed that the proposed method outperforms other state-of-the-art object segmentation algorithms in terms of recall and precision.
 KeywordsSaliency map, Depth map, deep learning, object segmentation
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Сплавы на основе олова и сурьмы, в том числе SnSb и некоторые другие соединения типа AIVBV, применяются для изготовления анодов Li+- и Na+-ионных батарей. Использование ногокомпонентных твердых растворов позволяет варьировать свойства материала и улучшать технические характеристики анодов. В литературе очень мало информации о твердофазной растворимости в системе Sn–As–Sb, фазовая диаграмма этой системы не изучена.Цель работы заключалась в исследовании политермических сечений SnAs–Sb и SnAs–SnSb с помощью методов рентгенофазового анализа (РФА) и дифференциального термического анализа (ДТА) и построении схемы фазовых равновесий в системе Sn–As–Sb в области концентраций олова менее 50 мол.%. Сплавы политермических разрезов SnAs–Sb и SnAs–SnSb получали из предварительно синтезированных бинарных соединений, подвергали гомогенизирующему отжигу и исследовали с помощью методов дифференциального термического анализа (ДТА) и рентгенофазового анализа (РФА) порошкообразных образцов. Результаты РФА показали, что все исследованные сплавы представляют собой гетерофазную смесь твердых растворов (SnAs), (SnSb) и a¢, где a¢ – твердый раствор олова в фазе As1–xSbx. Протяженность твердых растворов на основе бинарных соединений при комнатной температуре менее 10 мол.%. Для нескольких сплавов двух разрезов методомДТА установлена одинаковая температура начала первого эндотермического эффекта (393±2 oС), которая отвечает протеканию перитектического процесса с участием указанных выше фаз: L+ a¢ ↔ (SnAs) + (SnSb). Методом ДТА с учетом данных РФА построены Т–х диаграммы политермических разрезов SnAs–Sb и SnAs–SnSb. Установлены координаты нонвариантного перитектического равновесия L+ a¢ ↔ (SnAs) + (SnSb); предложена схема фазовых равновесий в системе Sn–As–Sb в области концентраций олова менее 50 мол.%. Для построения полной схемы фазовых равновесий в тройной системе необходимо дальнейшее исследование разрезов SnAs–Sn4Sb3 и Sn4As3–Sn4Sb3
 
 
 
 ЛИТЕРАТУРА
 
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A propósito do artigo sobre a trissomia 21, incluído neste número da Gazeta Médica, justo é lembrar o Dr. Dennis Lo, o médico (por Oxford), investigador e professor de Patologia Química da Universidade Chinesa da sua natal Hong Kong, que transformou a prática da obstetrícia enquanto pai dos testes pré-natais não invasivos (non-invasive prenatal testing – NIPT).
 Tendo em 1997 descoberto a presença de DNA fetal no sangue materno1, a sua investigação sobre o tema levou-o a desenvolver metodologias fiáveis de separação entre o DNA fetal e maternal circulantes bem como o diagnóstico pré-natal das aneuploidias cromossómicas do feto (trissomias 21,13 e 18)2, com 100% de sensibilidade e 98% de especificidade.3
 Em 2010, com a sua equipa faz a primeira e completa sequenciação do genoma fetal a partir do DNA isolado no sangue materno, ferramenta que pode permitir detetar a existência neste de mutações de novo e facilitar o estudo de alterações epigenómicas.4
 Em 1917 a equipe de Dennis Lo, utilizando uma tecnologia da área da transcriptómica identificou e esclareceu a dinâmica celular da placenta normal e a disfunção placentária da pré-eclampsia. Demonstrou também que as alterações placentárias podem ser identificadas no DNA materno circulante no plasma.4
 O Dr. Lo é também um pioneiro no desenvolvimento e aplicação em oncologia da tecnologia conhecida por “biópsia líquida”. Assim em 2013 defendeu e comprovou o conceito de que as alterações encontradas no DNA das células cancerosas podem ser detetadas no DNA livre circulante e libertado por essas células tumorais.5
 Como é sabido a identificação, por técnicas de biologia molecular (polimerase chain reaction real time, polimerase chain reaction digital, next generation sequencing, etc.), das alterações encontradas no DNA do genoma das várias neoplasias (mutações, fusões de genes, etc.) era e é feita, mais tipicamente, em tecido tumoral obtido através de biópsias tissulares cruentas. No seguimento dos trabalhos de Dennis Lo, outros investigadores aperfeiçoaram a “biópsia líquida”, tecnologia incruenta que, não apenas completou como se tornou numa alternativa à biópsia tissular e uma ferramenta com um impacto cada vez mais significativo no screening, diagnóstico, ajuda à decisão terapêutica, progressão e desfecho da doença oncológica.
 Atualmente a “biópsia líquida” permite isolar, a partir de uma simples colheita de 10 a 20 mL de sangue periférico, o DNA livre, oriundo de qualquer neoplasia existente no organismo ou de eventuais metástases que se possam desenvolver, mesmo após ser removido cirurgicamente o tumor primário, designadamente aquelas cuja localização se desconhece ou com um acesso que as torna impossíveis de biopsar, e de seguida submeter esse DNA às técnicas de biologia molecular já referidas. Claro que a questão que imediatamente se coloca é a da representatividade deste DNA tumoral relativamente ao tumor primário e metástases. Entre os muitos estudos de validação que demonstram a concordância entre estes, ressalta pela escala, o estudo apresentado na reunião anual de 2016 da American Society of Clinical Oncology que reporta uma avaliação genómica de 15 000 doentes com cancros avançados. Neste estudo a concordância entre a caracterização genómica do DNA circulante com a do tumor primário, sequenciado a partir de tecido biopsado foi de 87%, chegando aos 98% quando a colheita de sangue e do tecido foi feita com menos de seis meses de intervalo, sugerindo que a menor concordância refletia apenas evolução do tumor.6
 Como vimos o Dr. Lo e os NIPT estiveram na origem das biópsias líquidas. Por isso mesmo e por ironia o seu NIPT foi vítima do DNA circulante dos tumores maternos sendo esta uma das causas, das raríssimas causas, geradoras de falsos positivos do NIPT. Em 2013 Osborne et al7 descreveram o caso de uma grávida cujo NIPT realizado em duas amostras de sangue diferentes era sugestivo de aneuploidia 13 e 18. Não só o cariotipo era inteiramente normal como a criança também o era. Na continuidade e após uma fratura espontânea do púbis percebeu-se que havia um tumor metastizado e que as células do tumor primitivo apresentavam aneuploidias 13 e 18, o que significou que ao isolar-se o DNA do feto se isolou simultaneamente o DNA do tumor não se descortinando nenhuma alteração ao método que pudesse evitar esse percalço. 
 Depois destes alguns casos têm sido referidos na literatura. Na longa experiência que sobre estes testes temos no nosso laboratório nada de semelhante encontrámos. Apenas as gravidezes gemelares podem dificultar a especificidade do teste.
 Termino como comecei, louvando o patologista químico Dr. Dennis Lo pela importância que teve e terá nestas áreas da medicina laboratorial desejando-lhe uma longa vida para continuar a surpreender-nos com a sua investigação e descobertas. 
 Responsabilidades ÉticasCONFLITOS DE INTERESSE: Os autores declaram não possuir conflitos de interesse.SUPORTE FINANCEIRO: O presente trabalho não foi suportado por nenhum subsidio o bolsa ou bolsa.PROVENIÊNCIA E REVISÃO POR PARES: Comissionado; não teve revisão externa por pares.
 Ethical DisclosuresCONFLICTS OF INTEREST: The authors have no conflicts of interest to declare.FINANCIAL SUPPORT: This work has not received any contribution grant or scholarship.PROVENANCE AND PEER REVIEW: Commissioned; not externally peer reviewed.
 REFERÊNCIAS1. Lo YM, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CW, et al. Presence of fetal DNA in maternal plasma and serum. 1997; 350:485-7.2. Chiu RW, Chan KC, Gao Y, LauVY, Zheng W, Leung TY, et al. Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma. Proc Natl Acad Sci U S 2008;105:20458-63.3. Chiu RW, Akolekar R, Zheng YW, Leung TY, Sun H, Chan KC, et al. Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study. 2011; 342:c7401. doi: 10.1136/bmj.c7401.4. Lo YM, Chan KC, Sun H, Chen EZ, Jiang P, Lun FM, et al. Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci Transl Med. 2010; 2:61ra91. doi: 10.1126/scitranslmed.3001720.5. Chan KC, Jiang P, Chan CW, Sun K, Wong J, Hui EP, et al. Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing. Proc Natl Acad Sci U S A. 2013; 110:18761-8. doi: 10.1073/pnas.1313995110.6. Zill OA, Mortimer S, Banks KC, Nagy RJ, Chudova D, Jackson C, et al. Somatic genomic landscape of over 15,000 patients with advanced-stage cancer from clinical next-generation sequencing analysis of circulating tumor DNA.J Clin Oncol.2016;34 (Suppl.LBA):11501.7. Osborne CM, Hardisty F, Devers P, Kaiser-Rogers K, Hayden MA, Goodnight W,et al. Discordant noninvasive prenatal testing results in a patient subaequently diagnosed with metatatic Prenatal Diagn. 2013: 33:609-11. doi: 10.1002/pd.4100.