Relevant bibliographies by topics / MABC

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  2. Dissertations / Theses
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  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'MABC'

Author: Grafiati
Published: 4 June 2021
Last updated: 11 February 2022

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Journal articles on the topic "MABC"

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Capistrano, Renata, Elisa Pinheiro Ferrari, Luciano Portes de Souza, Thais Silva Beltrame, and Fernando Luiz Cardoso. "Concurrent validation of the MABC-2 Motor Tests and MABC-2 Checklist according to the Developmental Coordination Disorder Questionnaire-BR." Motriz: Revista de Educação Física 21, no. 1 (March 2015): 100–106. http://dx.doi.org/10.1590/s1980-65742015000100013.

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The Movement Assessment Battery for Children, 2nd Ed (MABC-2), comprised of motor tests and a questionnaire (Checklist), has been used by several nationalities to identify problems in children's motor behavior. However, the level of agreement between the motor tests and the checklist has been questioned. So, this study aimed to test the level of competition between the MABC-2 motor test and MABC-2 Checklist, controlled by the Developmental Coordination Disorder Questionnaire (DCDQ-BR) as the gold reference. Parents of 40 children and 16 teachers responded to the MABC-2 Checklist and the DCDQ-BR. Later 40 children were evaluated using the MABC-2 motor test. No significant congruence among a comparison of the MABC-2 motor tests, MABC-2 Checklist and DCDQ-BR was observed. The results indicated that there is no concurrent validity between the MABC-2 motor tests and the DCDQ-BR test, whereas the MABC-2 Checklist showed low levels of concurrent validity with the DCDQ-BR.
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Leone, Jose Pablo, Rachel A. Freedman, Michael J. Hassett, Julieta Leone, Sara M. Tolaney, Carlos Teodoro Vallejo, Bernardo Amadeo Leone, Eric P. Winer, and Nancy U. Lin. "Efficacy of neoadjuvant chemotherapy (NAC) in male breast cancer (MaBC) compared with female breast cancer (FBC): A National Cancer Database (NCDB) study." Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020): 587. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.587.

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587 Background: NAC is frequently used in the treatment of FBC. The efficacy of NAC in MaBC is unclear. Few studies have compared outcomes for MaBC and FBC after similar treatment. The aim of this study was to compare proportions of pathologic complete response (pCR) between MaBC and FBC according to tumor subtype (TS). Secondary aims were clinical response and overall survival (OS). Methods: We evaluated men and women with breast cancer treated with NAC between 2010 and 2016 with known hormone receptor (HR) status and human epidermal growth factor receptor 2 (HER2) status at NCDB centers. The proportion with pCR (ypT0/Tis ypN0) was compared for MaBC and FBC for each TS by Fisher’s exact test. Logistic regression evaluated odds of pCR. OS was estimated by Kaplan-Meier and compared by log-rank test. Results: Of 7,721 MaBC and 859,096 FBC patients, 385 MaBC (5%) and 68,065 FBC (7.9%) underwent NAC and were included in this study. Median age for MaBC was 58 years (y) (range 23-88) and for FBC was 53 y (range 18-90). Within each TS, there were no significant differences in the distribution of tumor grade between MaBC and FBC. Clinical stage in MaBC and FBC were: Stage I: 8% v 11%, Stage II: 54% v 59%, Stage III: 38% v 30%; respectively. Median time from initiation of NAC to surgery was 143 days in MaBC and 148 days in FBC. Compared with FBC, MaBC had a lower proportion of complete clinical response (18% v 31%) and a higher proportion of no clinical response (14% v 7%); p < 0.001. Proportions and odds of pCR were numerically lower in MaBC compared with FBC for each TS and statistically significant for HR+/HER2- and HR+/HER2+ (table). pCR was associated with OS in both MaBC and FBC. Specifically, in MaBC who achieved pCR v not, 5 y OS was 90% v 64.7%; p = 0.02. In FBC who achieved pCR v not, 5 y OS was 91.9% v 75.3%; p < 0.01. Among pts receiving NAC, MaBC had worse OS at 5 y than FBC (67.1% v 79.0%; p = 0.02). Conclusions: Men receiving NAC achieved lower proportions of pCR than women and had significantly worse OS. However, pCR is prognostic in both MaBC and FBC. Limitations include small sample sizes for HR-/HER2+ and triple-negative TS and lack of detailed regimen information. Nevertheless, our results suggest that, compared with FBC, MaBC may be intrinsically more resistant to NAC. [Table: see text]
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Rodriguez-Negro, Josune, and Javier Yanci. "Diferencias en función del género en el equilibrio estático y dinámico en estudiantes de educación primaria (Differences according to gender in static and dynamic balance in primary school students)." Retos, no. 35 (September 6, 2018): 113–16. http://dx.doi.org/10.47197/retos.v0i35.62848.

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Diferencias en función del género en el equilibrio estático y dinámico en estudiantes de educación primariaDifferences according to gender in static and dynamic balance in primary school studentsJosune Rodriguez-Negro, Javier YanciUniversidad del País Vasco (España) Resumen. Los objetivos principales de este estudio fueron describir, atendiendo al género, el equilibrio estático y dinámico de estudiantes de educación primaria (EP) mediante distintos test (MABC-2 estático, MABC-2 dinámico pasos, MABC-2 saltos pierna derecha, MABC-2 saltos pierna izquierda, standing stork pierna derecha y standing stork pierna izquierda), y analizar la asociación entre los resultados de los distintos test de equilibrio. 253 estudiantes de 2º a 5º de EP fueron evaluados, de los cuales 110 eran chicos (8.6 años, 133.7 ± 6.6 cm, 31.73 ± 6.1 kg, 17.6 ± 2,4 kg·m-2) y 143 chicas (8.7 años, 134.3 ± 9.1 cm, 32.9 ± 9.5 kg, 17.9 ± 3.3 kg·m-2). Los resultados obtenidos en el presente estudio muestran un mejor equilibrio estático en las chicas concretamente en las pruebas MABC-2 estático (p < .01, %Dif = -28.74%, TE = .3, bajo) y standing stork con la pierna derecha (p < .05, %Dif = 17.88%, TE = .2, bajo). Por el contrario, no se obtuvieron diferencias significativas entre chicos y chicas en el standing stork con la pierna izquierda, ni en ninguna de las pruebas de equilibrio dinámico (MABC-2 dinámico pasos, MABC-2 dinámico saltos con la pierna derecha y MABC-2 dinámico saltos con la pierna izquierda). Además, no se encontró ninguna correlación moderada, muy alta o casi perfecta (r > .50) entre los diferentes test de equilibrio. Los resultados obtenidos en este estudio muestran un mejor equilibrio estático en las chicas pero ninguna diferencia significativa atendiendo al género en el equilibrio dinámico. Abstract. The main objectives of this study were to describe, based on gender, the static and dynamic balance of primary education students through different tests (MABC-2 static, MABC-2 dynamic steps, MABC-2 jumps right leg, MABC- 2 jumps left leg, standing stork right leg and standing stork left leg), and analyze the association between the results of the different balance tests. 253 students from 2nd to 5th year of primary school were evaluated; 110 were boys (8.6 years, 133.7 ± 6.6 cm, 31.73 ± 6.1 kg, 17.6 ± 2.4 kg·m-2) and 143 girls (8.7 years, 134.3 ± 9.1 cm, 32.9 ± 9.5 kg, 17.9 ± 3.3 kg·m-2). The results obtained in the present study show a better static balance in girls, specifically in the static MABC-2 test (p < .01, %Dif = -28.74%, TE = .3, low) and standing stork with the right leg test (p < .05, % Dif = 17.88%, TE = .2, low). In contrast, no significant differences were found between boys and girls in the standing stork with the left leg, or in any of the tests of dynamic balance (MABC-2 dynamic steps, MABC-2 dynamic jumps with the right leg and MABC- 2 dynamic jumps with the left leg). In addition, no moderate, very high or almost perfect correlation (r> .50) were found between the different balance tests. The results obtained in this study show a better static balance in girls but no significant difference according to gender in dynamic balance.
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van der Veer, Gerda, Erica Kamphorst, Alexander Minnaert, Marja Cantell, Tanja H. Kakebeeke, and Suzanne Houwen. "Assessing Motor Performance in Preschool Children: The Zurich Neuromotor Assessment-2 and the Movement Assessment Battery for Children-2." Perceptual and Motor Skills 128, no. 5 (June 15, 2021): 2014–32. http://dx.doi.org/10.1177/00315125211025246.

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Comparing motor assessment tools that are available for young children is important in order to select the most appropriate clinical and research tools. Hence, this study compared motor performance assessed with the Zurich Neuromotor Assessment-2 (ZNA-2) to the Movement Assessment Battery for Children-2 (MABC-2). The sample consisted of 169 children, aged 3–5 years (87 boys; 51%). We used Pearson correlations to examine relationships between the ZNA-2 and MABC-2 component and total scores. In addition, Pearson correlations were performed between individual fine motor and balance items of the ZNA-2 and MABC-2. Results were that the total scores of the ZNA-2 and MABC-2 correlated moderately ( r = .40, p < .001). Non-significant to moderate correlations were found between components ( r = −.00 to .47) and between individual items of fine motor skills ( r = .04 to .38) and balance ( r = −.12 to .38). Thus, the ZNA-2 and MABC-2 measure partly similar and partly different aspects of motor performance.
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Li, Jun-yi, Yi-ding Zhao, Jian-hua Li, and Xiao-jun Liu. "Artificial Bee Colony Optimizer with Bee-to-Bee Communication and Multipopulation Coevolution for Multilevel Threshold Image Segmentation." Mathematical Problems in Engineering 2015 (2015): 1–23. http://dx.doi.org/10.1155/2015/272947.

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This paper proposes a modified artificial bee colony optimizer (MABC) by combining bee-to-bee communication pattern and multipopulation cooperative mechanism. In the bee-to-bee communication model, with the enhanced information exchange strategy, individuals can share more information from the elites through the Von Neumann topology. With the multipopulation cooperative mechanism, the hierarchical colony with different topologies can be structured, which can maintain diversity of the whole community. The experimental results on comparing the MABC to several successful EA and SI algorithms on a set of benchmarks demonstrated the advantage of the MABC algorithm. Furthermore, we employed the MABC algorithm to resolve the multilevel image segmentation problem. Experimental results of the new method on a variety of images demonstrated the performance superiority of the proposed algorithm.
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Winthrop, Kevin, and Luke Strnad. "Treatment of Mycobacterium abscessus Complex." Seminars in Respiratory and Critical Care Medicine 39, no. 03 (June 2018): 362–76. http://dx.doi.org/10.1055/s-0038-1651494.

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AbstractOf the nontuberculous mycobacteria (NTMs) causing lung disease, members of the Mycobacterium abscessus complex (MABc) present a formidable obstacle to successful management. This challenge starts from a poorly understood pathogenesis, continues with complicated subspecies variation in treatment response, and extends to the multidrug-resistant nature of these organisms. The disease often necessitates the use of intravenous therapy, toxic drug combinations, and, in some cases, lung resection. Like many NTMs, MABc treatment requires prolonged therapy with multiple medications, and pulmonary disease in some subspecies can be impossible to eradicate or cure. This disease also represents a frequent and unique problem in certain populations, including cystic fibrosis and lung transplant recipients, and providers who manage such patients should be familiar with how MABc disease influences management. Because of the rising prevalence of the MABc, especially in patients with complicated underlying pulmonary disease, it is increasingly necessary for infectious diseases and pulmonary medicine clinicians to understand the unique aspects of MABc management and understand when to obtain expert consultation in the care of these patients.
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Babu, N. Ashok, and R. Kumar. "Load Balancing Clustering in WSN using MABC." Research Journal of Information Technology 6, no. 4 (April 1, 2014): 389–98. http://dx.doi.org/10.3923/rjit.2014.389.398.

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Ab. Rashid, M. F. F., N. M. Z. Nik Mohamed, and A. N. Mohd Rose. "A modified artificial bee colony algorithm to optimise integrated assembly sequence planning and assembly line balancing." Journal of Mechanical Engineering and Sciences 13, no. 4 (December 30, 2019): 5905–21. http://dx.doi.org/10.15282/jmes.13.4.2019.13.0469.

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Assembly Sequence Planning (ASP) and Assembly Line Balancing (ALB) are traditionally optimised independently. However recently, integrated ASP and ALB optimisation has become more relevant to obtain better quality solution and to reduce time to market. Despite many optimisation algorithms that were proposed to optimise this problem, the existing researches on this problem were limited to Evolutionary Algorithm (EA), Ant Colony Optimisation (ACO), and Particle Swarm Optimisation (PSO). This paper proposed a modified Artificial Bee Colony algorithm (MABC) to optimise the integrated ASP and ALB problem. The proposed algorithm adopts beewolves predatory concept from Grey Wolf Optimiser to improve the exploitation ability in Artificial Bee Colony (ABC) algorithm. The proposed MABC was tested with a set of benchmark problems. The results indicated that the MABC outperformed the comparison algorithms in 91% of the benchmark problems. Furthermore, a statistical test reported that the MABC had significant performances in 80% of the cases.
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Delcourt, Candice, Cheryl Carcel, Danni Zheng, Shoichiro Sato, Hisatomi Arima, Sonu Bhaskar, Pierre Janin, et al. "Comparison of ABC Methods with Computerized Estimates of Intracerebral Hemorrhage Volume: The INTERACT2 Study." Cerebrovascular Diseases Extra 9, no. 3 (December 13, 2019): 148–54. http://dx.doi.org/10.1159/000504531.

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Background and Purpose: Hematoma volume is a key determinant of outcome in acute intracerebral hemorrhage (ICH). We aimed to compare estimates of ICH volume between simple (ABC/2, length, width, and height) and gold standard planimetric software approaches. Methods: Data are from the second Intensive Blood Pressure Reduction in Acute Cerebral Hemorrhage Trial (INTERACT2). Multivariable linear regression was used to compare ICH volumes on baseline CT scans using the ABC/2, modified ABC/2 (mABC/2), and MIStar software. Other aspects of ICH morphology examined included location, irregularity, heterogeneity, intraventricular and subarachnoid hemorrhage extension (SAH) of hematoma, and associated white matter lesions and brain atrophy. Results: In 2,084 patients with manual and semiautomated measurements, median (IQR) ICH volumes for each approach were: ABC/2 11.1 (5.11–20.88 mL), mABC/2 7.8 (3.88–14.11 mL), and MIStar 10.7 (5.59–18.66 mL). Median differences between ABC/2 and MIStar, and mABC/2 and MIStar were 0.34 (–1.01 to 2.96) and –2.4 (–4.95 to –0.7416), respectively. Hematoma volumes differed significantly with irregular shape (ABC/2 and MIStar, p < 0.001; mABC/2 and MIStar, p = 0.007) and larger volumes (mABC/2 and MIStar, p < 0.001; ABC/2 and MIStar, p = 0.07). ICH with SAH showed a significant discrepancy between ABC/2 and MIStar (p < 0.001). Conclusions: Overall, ABC/2 performs better than mABC/2 in estimating ICH volume. The largest discrepancies were evidenced against automated software for irregular-shaped and large ICH with SAH, but the clinical significance of this is uncertain.
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Wattad, Rasha, Lidia V. Gabis, Shahar Shefer, Sarit Tresser, and Sigal Portnoy. "Correlations between Performance in a Virtual Reality Game and the Movement Assessment Battery Diagnostics in Children with Developmental Coordination Disorder." Applied Sciences 10, no. 3 (January 24, 2020): 833. http://dx.doi.org/10.3390/app10030833.

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We aimed to compare the performance in a Virtual Reality (VR) game between Typically Developed (TD) children and children with Developmental Coordination Disorder (DCD). We then compared the performance in a VR game with the sub-grades of the Movement Assessment Battery for Children (MABC). Twenty TD children (10 boys; mean and SD age 5.1 ± 0.6) and 10 children with DCD (4 boys; mean and SD age 5.6 ± 0.6) participated in the study. The parents filled out the DCD questionnaire. The MABC was administered. Each subject stood on a pressure pad and played a non-immersive VR game. The game score, hand path length, and movement of center of pressure were recorded. The game score achieved by the control group was ~22% higher compared to the game score achieved by the research group (p = 0.042). The path length of the right hand strongly correlated with the visual-motor coordination MABC subcategory score (r = 0.902, p < 0.001), with the balance MABC subcategory score (r = 0.769, p = 0.009), and with the total MABC score (r = 0.667, p = 0.035). This VR game might provide a preliminary distinction between TD children and children with DCD. Furthermore, investigation of hand path length may reflect the visual-motor coordination impairment of the child.
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Dissertations / Theses on the topic "MABC"

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Silveira, Rozana Aparecida da. "Avaliação das baterias motoras EDM, MABC-2 e TGMD-2." Universidade do Estado de Santa Catarina, 2010. http://tede.udesc.br/handle/handle/493.

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Made available in DSpace on 2016-12-06T17:07:28Z (GMT). No. of bitstreams: 1 ROZANA APARECIDA DA SILVEIRA.pdf: 980901 bytes, checksum: 2f4593478f80d69b689ed45118c5ce0f (MD5) Previous issue date: 2010-03-18
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This study aimed to evaluate the batteries motor EDM, TGMD-2 and MABC-2 in terms of: validation, reliability testing by internal consistency and inter-relationship and aimed to evaluate the motor skills of children aged 9 and 10 years old. Qualityquantitative research consisted of field, although not representative probability, descriptive correlational design with between and intraparticipantes as the established objectives. We evaluated 172 children, including 67 boys and 105 girls enrolled. Collections totaled 516, since each child was assessed by three batteries motor. In the analysis of construct items engines, it was observed that the batteries motor skills were grouped separately to the grouping suggested by the authors. Comparing the possible items of batteries, it was noticed that the MABC-2 has a greater affinity between the other batteries motor. The batteries motor MABC-2 and EDM, EDM and TGMD-2 showed positive and batteries TGMD and MABC-2-2 were negatively correlated, although all correlations are weak. In terms of reliability, TGMD-2 showed high internal consistency of the item "control objects" (α =. 717) and the instrument as a whole (α =. 723), indicating its reliability. In the analysis of motor skill development through the application of traction batteries, it was found that, according to EDM, in general, participants showed a deficit in general motor development, with respect to chronological age, with motor age of 109 months or approximately 9 years and getting better performance in the temporal organization and weaker performance in spatial organization, possibly due to difficulty with the notion of right to left. Boys had higher performance than the girls in all motor skills, body scheme except / speed. According to the MABC-2, participants rated themselves on the track "borderline" of motor development, with better scores in balance and weak scores on manual dexterity. Finally, according to the classification of TGMD-2, the children obtained average result in locomotion skills and below average skills in tracking objects. Regarding gender differences, boys, in general, performed better than girls in three batteries motor.
O presente estudo visou avaliar as baterias motoras EDM, MABC-2 e TGMD-2 em termos de: validação, confiabilidade mediante testagem da consistência interna e inter-relação, bem como objetivou avaliar o desempenho nas habilidades motoras de crianças com 9 e 10 anos de idade. Consistiu em pesquisa qualiquantitativa, de campo, representativa embora não probabilística, descritiva correlacional com delineamento entre e intraparticipantes conforme os objetivos traçados. Foram avaliados 172 escolares, sendo 67 meninos e 105 meninas, regularmente matriculados. Totalizou 516 coletas, uma vez que cada criança foi avaliada pelas três baterias motoras. Na análise de construto dos itens motores, observou-se que as habilidades das baterias motoras agruparam-se de forma distinta ao agrupamento sugerido pelos autores. Ao se comparar os itens possíveis das baterias, percebeu-se que o MABC-2 possui maior afinidade entre as demais baterias motoras. As baterias motoras MABC-2 e EDM, EDM e TGMD-2 apresentaram correlação positiva e as baterias MABC-2 e TGMD-2 apresentaram correlação negativa, embora todas as correlações obtidas sejam fracas. Em termos de confiabilidade, o TGMD-2 apresentou consistência interna do item controle de objetos (α=.717) e do instrumento como um todo (α=.723), indicando sua fidedignidade. Na análise do desenvolvimento motor das crianças por meio da aplicação das baterias motoras, verificou-se que, segundo a EDM, em geral os participantes apresentaram déficit no desenvolvimento motor geral, com relação à idade cronológica, apresentando idade motora de 109 meses ou aproximadamente 9 anos e obtendo melhor desempenho em organização temporal e desempenho mais fraco em organização espacial, possivelmente em decorrência à dificuldade com a noção de direita-esquerda. Os meninos apresentaram desempenho superior às meninas em todas as habilidades motoras, exceto em esquema corporal/rapidez. De acordo com o MABC-2, os participantes classificaram-se na faixa limítrofe de desenvolvimento motor, apresentando melhores escores em equilíbrio e escores fracos em destreza manual. Por fim, conforme a classificação do TGMD-2, as crianças obtiveram resultado médio nas habilidades de locomoção e abaixo da media nas habilidades de controle de objetos. Em relação às diferenças entre os sexos, os meninos, de um modo geral, obtiveram melhor desempenho do que as meninas nas três baterias motoras.
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BAKKE, Hanne Alves. "Adaptação e validação do MABC-2 para crianças com baixa visão." UNIVERSIDADE FEDERAL DE PERNAMBUCO, 2015. https://repositorio.ufpe.br/handle/123456789/15053.

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CNPQ
O objetivo deste estudo foi adaptar e validar o Movement Assessment Battery for Children-2 (MABC-2) para crianças com baixa visão. Para isso, a pesquisa foi desenvolvida em três etapas: 1) tradução, validação e análise das propriedades psicométricas do MABC-2 (7 a 10 anos); 2) levantamento das dificuldades das crianças com baixa visão durante a aplicação do teste e adaptação; e 3) aplicação e validação do MABC-2 adaptado. O processo de tradução foi composto por quatro fases: tradução, retro-tradução, avaliação por comitê e validação de face e incluiu o Registration Form e os capítulos 2 e 3 do manual. Participaram da primeira etapa do estudo 32 crianças normovisuais de uma escola municipal de Recife (PE). Em seguida, a versão em português aprovada foi aplicada em 10 crianças com baixa visão com o intuito de levantar as suas dificuldades durante o teste e as propostas das modificações. Após a aprovação da versão adaptada, o teste foi aplicado em 30 crianças com baixa visão, do estado de Pernambuco. A acuidade visual para longe destas crianças era 6/18> x ≥3/60 no melhor olho com a melhor correção. Todas as crianças tinham idades entre 7 e 10 anos e não possuíam nenhum distúrbio associado. O processo de tradução resultou em uma versão com boa aceitação pelos profissionais. Considerando a classificação quanto à dificuldade de movimento, o CCI inter-avaliador variou de 0,368 a 0,815, e teste-reteste, de 0,170 a 0,536. A consistência interna foi considerada aceitável (0,549< α < 0,668). A análise fatorial não demonstrou evidências da confirmação da estrutura multidimensional proposta pelos autores do MABC-2, com problemas entre as correlações das variáveis, extração no número de fatores, assim como no agrupamento dos subtestes. A aplicação do MABC-2 original nas crianças com baixa visão (n=10) resultou em adaptações no material do kit, nos procedimentos e no ambiente. O MABC-2 adaptado revelou confiabilidade inter-avaliador de alta para muito alta, com 0,923 < ICC < 0,975 e concordância de considerável a excelente quanto à classificação da dificuldade de movimento (0,669 < ICC < 0,888). A ferramenta adaptada apresentou consistência interna boa (0,790< α < 0,868). As correlações entre os escores padrões do MABC-2 original e adaptado foram muito altas entre escores de componentes e total do teste. Apesar de gerar uma versão em português aprovada pelo Comitê, com índices satisfatórios de reprodutibilidade inter-avaliador e de consistência interna, o MABC-2 original demonstrou-se problemático na composição de seus domínios, sugerindo a necessidade de modificações em alguns de seus itens para este seja aplicado em crianças do Brasil. A versão adaptada do MABC-2 para crianças com baixa visão também apresentou índices aceitáveis de confiabilidade inter-avaliador e de consistência interna, e apresentou altas correlações com a versão original do teste, sugerindo que elas avaliam o mesmo constructo. No entanto, a variabilidade na concordância teste-reteste em ambas as versões, dá indícios de que esta ferramenta pode ser melhor para triagem ou para auxiliar na tomada de decisão na prática clínica de que para acompanhamento da evolução de intervenções.
This research had as an objective to adapt and validate the Movement Assessment Battery for Children-2 (MABC-2) for children with low vision. The study was developed in three stages: 1) translation, validation and psychometric properties analysis of MABC-2 (7 to 10 years); 2) investigation of the difficulties by the low vision children during the application of the test and adaptations; and 3) application and validation of the adapted MABC-2. The translation process was conducted in four stages: translation, back-translation, evaluation for committee and face validation. It included the Registration Form and chapters 2 and 3 of the examiner’s manual. 32 normovisual children from a municipal school of Recife participated in the first stage of the study. Afterwards, the Portuguese approved version was applied in 10 children with low vision to investigate their difficulties during the test and the modification proposals. With the approval of the adapted version, the test was applied in 30 low vision children from Pernambuco state. These children's visual acuity was 6/18> x ≥ 3/60 in the best eye with the best correction. All of the children had ages between 7 and 10 years and had no associated pathologies. The translation process resulted in a good acceptance version by the professionals. Considering the movement difficulty classification, ICC inter-observer varied from 0,368 to 0,815, and the test-retest, from 0,170 to 0,536. The internal consistency was considered acceptable (0,549 < α <0,668). Factorial analysis didn't give evidence to support the multidimensional structure of MABC-2 as proposed by the authors, demonstrating problems with variable correlations, number of factors extracted, as well as in subtests grouping. The application of the original MABC-2 in low vision children (n=10) resulted in adaptations in kit material, procedures and in the surroundings. Adapted MABC-2 revealed high to very high inter-observer reliability varying from 0,923 to 0,975, and reasonable to excellent agreement considering the movement difficulty classification (0,669 < α <0,888). The adapted version showed good internal consistency (0,790 < α <0,868). The correlations between the standard scores of the two MABC-2 versions (original and adapted) were very high among component and total test scores. In spite of an approved Portuguese version by the committee, and satisfactory inter-observer reproducibility and internal consistency values, the original MABC-2 was problematic in the composition of its domains, suggesting the need of modifications in some items for the application in children of Brazil. The MABC-2 adapted version for low vision children also demonstrated acceptable inter-observer reliability and internal consistency, as well as high correlations with the original version of the test, suggesting that they evaluate the same construct. However, the test-retest reliability in both versions indicates that the tool may be better for general assessments or for aiding in decision making process in clinical practice, rather than for evaluating intervention effects.
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Montoro, Ana Paula Pietro Nobre. "Validação concor-rente do MABC-2 Teste Motor com o DCDQ BR: estudo preliminar para a faixa etária de 7 a 10 anos." Universidade do Estado de Santa Catarina, 2015. http://tede.udesc.br/handle/handle/328.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Introdução: O movimento é um componente fundamental do ser humano, que lhe permite satisfazer as necessidades básicas da vida. Por este motivo é tão importante avaliar e mensurar os impactos da competência motora na vida das crianças. Uma das ferramentas mais utilizadas para identifi-car crianças com dificuldades motoras é a Movement Assessment Battery for Children Segunda Edição (MABC-2), composta por testes motores e um questionário (MABC-2 Checklist), esse instrumento tem sido usado e testado em várias nacionalidades (Estados Unidos, Japão, China, Espanha, Grécia). Na atualidade os estudos apresentam controvérsias a respeito da eficácia dos instrumentos utilizados pa-ra avaliar o desenvolvimento motor. Objetivos: Esse estudo objetivou verificar a validade concorrente do Movement Assessment Battery for Children Segunda Edição (MABC-2) - Teste Motor para crianças de 7 a 10 anos (faixa etária 2 do MABC-2) com o Developmental Coordination Disorder Questionnaire Brasil (DCDQ-BR). Conseguinte, o primeiro artigo tem como finalidade investigar os testes motores validados para avaliar o desempenho motor de crianças por meio de uma revisão sistemática. No segundo artigo o objetivo foi verificar a validade concorrente da bateria motora do MABC-2 com o DCDQ-BR de acordo com o sexo e a faixa etária. Método: No primeiro artigo foi realizada uma busca nas bases de dados eletrônicas, Medline/PubMed (Medical Literature Analysis and Retrieval Systen),Web of Science e Scopus , seguindo o critério de inclusão adotados. Foram utilizados para a pesquisa os descritores na língua inglesa: (motor skills disorders), (validation studies or vali-dity), (child or children or only child). Com base nos critérios de busca e seleção, foram identificados 859 artigos. Destes, 624 foram excluídos com base na análise do título, 235 foram selecionados por resumos e para leitura na íntegra foram elegidos 108 estudos. Após a leitura dos artigos na íntegra, 29 trabalhos atenderam os critérios de inclusão que contemplam esta revisão. A qualidade dos artigos foi avaliada usando-se o Strengthening the Reporting of Obser-vational Studies in Epidemiology (STROBE). O segundo artigo que apresenta também o método geral do trabalho, constitui um estudo de validação caracterizado como pesquisa exploratória, com uma população selecionada de forma intencional. Foram avaliados 350 escolares sendo 175 meninas e 176 meninos do município da Grande Florianópolis SC e Manaus AM e seus pais ou responsáveis. Foram realizados os testes motores do instrumento MABC-2 (faixa etária 2), com crianças nas idades de 7 a 10 anos. O instrumento DCDQ-BR, foi respondido pelos pais ou responsáveis dos escolares. Após a coleta, para a caracterização dos dados foi utilizada a análise estatística descritiva realizada por meio de freqüências relativas e absoluta. E para verificar a normalidade dos dados o teste Kolmogorov-Smirnov. Porém, as variáveis não apresentaram com distribuição normal, desta forma, foram utilizados, para análise inferencial, apenas testes não paramétricos. A comparação entre as faixas etárias foi realizada por meio dos testes U de Mann-Witney e o coeficiente de Correlação de Spearman para a validação concorrente. Em todas as análises estatísti-cas foi adotado o nível de significância p≤0,05. Resultados: Referente ao artigo 1, os instrumentos de avaliação motora mais utilizados nos estudos foi a Movement Assesment Bat-tery for Children (MABC), Developmental Test of Visual Motor (VMI-5), Bruininks-Oseretsky Test of Motor Profici ency (BOTMP), Movement Assesment Battery for Children (MABC 2) e o Developmental Coordination Disorder Ques-tionnaire (DCDQ). Nos critérios de validação dos instrumentos os métodos mais utilizados foram: validação concorrente, seguido da validação de constructo e adaptação transcultural. No segundo artigo, a validade concorrente apresentou uma correlação positiva e significativa apresentando valores de (r= 0,40; r= 0,60) entre os instrumentos, independentes do sexo e da faixa etária. Para as classificações motoras foram agrupadas em Risco/Dificuldade de Movimento e Sem Dificuldade de Movimento. Quanto à desordem motora mediante a classificação do teste motor MABC-2, houve maior prevalência no sexo masculino na faixa etária 09-10. Diante dos resultados apontados, esta pesquisa fornece evidências para considerar o MABC-2 como um protocolo de avaliação motora para ser utilizado em crianças de duas regiões do país, legitimando-se como uma ferramenta de triagem para o diagnóstico do Transtorno do Desenvolvimento da Coordenação TDC.
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Morgan-Jones, Melanie. "Does Fascia Bowen therapy improve neuromuscular function and psychological well-being in males aged 8-11 (at primary school) with dyspraxia/developmental coordination disorder?" Thesis, University of Bath, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665409.

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Background: Dyspraxia, also included under the term Developmental Coordination Disorder (DCD), is a condition characterised by an impairment in motor skills function which impacts negatively on other aspects of daily living such as athletic capability, handwriting, self-esteem and social interaction. However, no effective therapy currently exists to address all of these issues within this group. The aim of the present study therefore was to investigate whether a complementary therapy, called Fascia Bowen therapy, would improve neuromuscular function and psychological wellbeing in males aged 8-11 (at Primary School) diagnosed with this condition. Methods: A group of 10 participants meeting the criteria of 15th centile or below in motor skills functioning, received a Fascia Bowen therapy treatment session from a qualified Fascia Bowen practitioner each week for 6 weeks. All participants’ motor skills function were assessed by an occupational therapist before and after the end of the intervention using the Motor Skills Assessment Battery for Children test (MABC-2). Additionally, parents, teachers and participants completed questionnaires measuring self-esteem, social skills, social interaction, behaviour and scholastic function before and after the intervention. Results: The participants showed significant improvement in neuromuscular function over time using the MABC-2. However, no significant changes were shown in the other measures of functioning. Although parents did provide some anecdotal reports about positive changes in real life, these were not reflected in the measures. The results suggest that while improvements were shown as significant in the motor domain, which was the focus of the therapy, the results did not translate to other domains of life over time. 13 Conclusions: Further research is necessary to test the efficacy of the treatment’s effects using a larger sample, a control group and a longer intervention timescale. A six week intervention period may not be sufficient to show significant changes in self-esteem, social skills, social interaction, behaviour and scholastic functions which have deep-rooted constructs developed over many years. These may therefore take a long time to change.
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Uffreduzzi, Alessio. "Strumentazione mediante sensori inerziali di test per la valutazione delle funzioni visuo-spaziali costruttive in età evolutiva: uno studio preliminare." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2017.

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L’obiettivo di questa tesi è quello di indagare la possibilità di strumentare mediante sensori inerziali indossabili alcuni test per la valutazione delle competenze visuo-costruttive: “Salvadanaio” (Posting Coins), “Invertire i pioli” (Turning Pegs) e “Laccio” (Threading Lace) della batteria Movement ABC. A tal fine si è valutata la possibilità di utilizzare parametri quantitativi utilizzati in analisi del movimento per la caratterizzazione della performance dell’arto superiore durante compiti che richiedono appunto abilità visuo-costruttive. Hanno preso parte allo studio undici soggetti adulti giovani sani e quattro bambini con sviluppo tipico. Dopo aver posizionato i sensori inerziali sui polsi è stato richiesto ai soggetti di svolgere i test sopraelencati come da manuale di riferimento. Da questo studio preliminare, i parametri che sono risultati più rilevanti per la caratterizzazione delle abilità visuo-costruttive sono stati la complessità (misurata con la Multiscale Entropy) e la frequenza mediana, stimate sul segnale accelerometrico dell’arto che eseguiva l’esercizio. Questi parametri hanno mostrato, come atteso, un trend diverso tra soggetti adulti e quelli in età evolutiva. I risultati di questo studio potranno essere utilizzati come base di partenza per ulteriori sviluppi futuri.
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Nagel, Marc G. "Numerische Optimierung dreidimensional parametrisierter Turbinenschaufeln mit umfangsunsymmetrischen Plattformen Entwicklung, Anwendung und Validierung /." [S.l.] : [s.n.], 2004. http://137.193.200.177/ediss/nagel-marc/meta.html.

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Park, ChanYoung Foucart Bruno. "La Bible illustrée par Marc Chagall (1887-1985) un dialogue interculturel et son évolution /." S. l. : S. n, 2008. http://www.theses.paris4.sorbonne.fr/thesepark.pdf.

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Kulkarni, Santosh B. Umphress David A. Agrawal Prathima. "Synergy MAC a cooperative MAC protocol /." Auburn, Ala, 2009. http://hdl.handle.net/10415/1609.

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Garcia, Maysa Dias. "O MAB." reponame:Repositório Institucional da UFSC, 1990. https://repositorio.ufsc.br/xmlui/handle/123456789/157623.

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Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciencias Humanas
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A dissertação focaliza a história do MAB (Movimento de Associações de Bairro de Curitiba e Região Metropolitana) no contexto do processo de formação e crescimento das áreas periféricas, bem como do início do processo de organização popular na década de 80. Argumenta-se que o MAB, em função de ter sido criado a partir das CEB'S e do Centro de Formação Urbano Rural irmã Araujo (CEFURIA) conseguiu desenvolver junto a associações de moradores uma forma de atuação diferente de outras entidades populares ali existentes (a exemplo da União Geral de Bairros, Vilas e Jardins de Curitiba e da Federação de Associação de Moradores do Paraná). Tenta-se demonstrar que o MAB chegou a desenvolver um novo padrão de prática política inspirada na ética social vivenciada pelas CEB'S e pelo CEFURIA.
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Dreher, Fabian [Verfasser], Marc [Akademischer Betreuer] Keßeböhmer, and Johannes [Akademischer Betreuer] Jaerisch. "Über Ausströmraten spezieller Flüsse / Fabian Dreher. Betreuer: Marc Keßeböhmer. Gutachter: Marc Keßeböhmer ; Johannes Jaerisch." Bremen : Staats- und Universitätsbibliothek Bremen, 2015. http://d-nb.info/107786437X/34.

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Books on the topic "MABC"

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S, J. Llop. Marc. Barcelona: Gal Art, 1996.

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Mabu. Sŏul-si: Kʻŏmyunikʻeisyŏn Buksŭ, 2005.

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Kagan, Andrew. Marc Chagall. New York: Abbeville Press, 1989.

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Emert, Phyllis Raybin. Marc Chagall. Farmington Hills, Michigan: Lucent Books, 2014.

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Bernard & Gwénolée Zürcher Galerie., ed. Marc Desgrandchamps. Paris: Panama musées, 2008.

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Marc Andreessen. New York: Rosen Publishing, 2015.

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Marc Chagall. Munich: Prestel, 2004.

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Greenfeld, Howard. Marc Chagall. New York: Abrams, 1989.

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Bourkoff, Véronique. Marc Dorlan. [Sainte-Clotilde, Réunion]: Éditions Orphie, 2008.

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Edward, Lucie-Smith. Marc Chagall. London: BBC, 1985.

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Book chapters on the topic "MABC"

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Hutchins, Tiffany, Giacomo Vivanti, Natasa Mateljevic, Roger J. Jou, Frederick Shic, Lauren Cornew, Timothy P. L. Roberts, et al. "MABC." In Encyclopedia of Autism Spectrum Disorders, 1773. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_100839.

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Hutchins, Tiffany, Giacomo Vivanti, Natasa Mateljevic, Roger J. Jou, Frederick Shic, Lauren Cornew, Timothy P. L. Roberts, et al. "MABC-2." In Encyclopedia of Autism Spectrum Disorders, 1773. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_100840.

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Hutchins, Tiffany, Giacomo Vivanti, Natasa Mateljevic, Roger J. Jou, Frederick Shic, Lauren Cornew, Timothy P. L. Roberts, et al. "Movement Assessment Battery for Children: 2nd Edition (MABC-2)." In Encyclopedia of Autism Spectrum Disorders, 1925–39. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4419-1698-3_1922.

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Brown, Ted. "Movement Assessment Battery for Children: 2nd Edition (MABC-2)." In Encyclopedia of Autism Spectrum Disorders, 1–20. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4614-6435-8_1922-3.

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Brown, Ted. "Movement Assessment Battery for Children: Second Edition (MABC-2)." In Encyclopedia of Autism Spectrum Disorders, 3000–3018. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-319-91280-6_1922.

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Alinezhad, Alireza, and Javad Khalili. "MABAC Method." In New Methods and Applications in Multiple Attribute Decision Making (MADM), 193–98. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-15009-9_25.

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Wild, Gerhard. "Bloch, Marc." In Kindlers Literatur Lexikon (KLL), 1. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_2781-1.

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Wild, Gerhard. "Chagall, Marc." In Kindlers Literatur Lexikon (KLL), 1. Stuttgart: J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_3105-1.

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Yap, Mandy, and Eunice Yu. "Mabu liyan." In Routledge Handbook of Indigenous Wellbeing, 261–80. Abingdon, Oxon ; New York, NY : Routledge, 2019. | Series: Routledge international handbooks: Routledge, 2019. http://dx.doi.org/10.4324/9781351051262-22.

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Weber, Wolfgang E. J. "Marc Bloch." In Kindler Kompakt Klassiker der Geschichtsschreibung, 168–70. Stuttgart: J.B. Metzler, 2016. http://dx.doi.org/10.1007/978-3-476-05530-9_48.

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Conference papers on the topic "MABC"

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Zuo, Fangzhi, and Min Dong. "Low-complexity SNR-based channel pairing in multichannel MABC-based two-way relaying." In 2013 IEEE 14th Workshop on Signal Processing Advances in Wireless Communications (SPAWC 2013). IEEE, 2013. http://dx.doi.org/10.1109/spawc.2013.6612071.

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Chang, Mingchun, Min Dong, and Shahram ShahbazPanahi. "Joint pairing and power allocation optimization in multichannel MABC-based two-way relaying." In 2014 IEEE 15th International Workshop on Signal Processing Advances in Wireless Communications (SPAWC). IEEE, 2014. http://dx.doi.org/10.1109/spawc.2014.6941689.

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Ingerslev, J., S. Stenbjerg, A. Bukh, NPH Møller, and J. Zeuthen. "EVIDENCE FOR AN ABNORMAL EXPRESSION OF THE COLLAGEN BINDING DOMAIN IN VON WILLEBRAND'S DISEASE TYPE II." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644644.

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A recently developed new series of monoclonal antibodies (MAbs) against the von Willebrand factor (vWf) included antibodies strongly inhibiting ( Mab vWf-41) and partly inhibiting ( Mab vWf-33) the collagen binding of vWf. We also characterized two Mabs with interacting properties against the ristocetin induced platelet aggregation (MAbs vWf-21 and vWf-39). These antibodies were conjugated with horse-radish peroxidase (HRP) and examined in different constructions forming two-site MAb ELISA's for plasma vWf:Ag and compared with polyclonal antibody ELISA. Symmetrical MAb-ELISA ( i.e. same Mab for extraction and detection) gave practical no dose-response in the standard assay, whereas any different combination of Mabs gave favourable dose-response relationships in sensitive ELISA's for vWf:Ag. Two different sandwiches were chosen using MAb vWf-33 and Mab vWf-41 at either side of the ELISA. These two assay models gave results of plasma from normal persons almost identical to those obtained with polyclonal antibody ELISA. Also in type I von Willebrand's disease these three assays performed very uniformly. In subtypes II plasma ( IIA: n=7; IIB: n=3, IIC: n=l, IID: n=i) . the assay using vWf-33 for coating and vWf-41-HRP for detection measured considerably lower than the polyclonal ELISA and the Mab-ELISA based on the opposite combination. We believe, that our results are indicative of a molecular defect in the collagen binding domain of vWf in subtype II plasma.
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Rathjen, A., and Carolyn L. Geczy. "PRODUCTION AND CHARACTERISATION OF MONOCLONAL ANTIBODIES AGAINST HEPARIN Deborah." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644188.

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To complement the studies using MAbs to AT III and because of the reported ability of heparin to modulate several aspects of the cell-mediated immune response, we have prepared two mouse monoclonal antibodies (MAbs) to porcine mucosal heparin.MAb 25/15 is an IgGl and MAb 26/7 is an IgM. Both MAbs have iso-electric points between pH5.85 and 6.55. The MAbs recognise porcine and bovine mucosal heparin and rat mast cell heparin. Heparins with both high and low affinitiesfor antithrombin III (ATIII) bound both MAbs but neither MAb altered the binding of heparin to AT III. These antibodies did not recognise other proteoglycans (chondroitin sulphate types A, B and C, keratan sulphate and hyaluronic acid) with the exception of heparan sulphate, (the cellular equivalent of heparin) and Arte- paron (Luitpold-Werk, Munchen; a synthetically poly- sulphated chondriotin sulphate), in competition and solid-phasebinding assays. Dextransulphate(Pharmacia) was also recognised by these MAbs. Cross-reactivity with Arteparon and dextran sulphate indicate that charged sulphate goups on the mucopolysaccharides may be importantBfor MAb binding. The Mabs described may beuseful probes for endogenous heparin at the cellular and tissue level and may allow further investigation of the many biological activitiesof heparin
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Steven, I., L. Wagner, W. E. van Nostrand, and D. D. Cunningham. "PREPARATION AND CHARACTERIZATION OF MONOCLONAL ANTIBODIES TO PROTEASE NEXIN." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644447.

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Protease nexin I (PN-1) is a cell-secreted protease inhibitor which modulates the activity of certain serine proteases in the extracellular environment. To probe PN-1 functions, we prepared a panel of monoclonal antibodies (mAbs) against it and studied their effects on a variety of PN-1 activities. Three highly potent inhibitors of PN-1 activity have been characterized. MAbs pl-6 and pl-9 stoichiometri-cally block PN-l-mediated anti-thrombin and anti-urokinase activity. These mAbs block PN-l-mediated anti-trypsin activity less effectively. MAb pl-18 stoichiometrically blocks all PN-1 antiprotease activities tested including anti-trypsin activity and therefore appears to bind at the reactive center of PN-1. Heparin, which greatly accelerates PN-1 anti-thrombin activity, does not compete with the binding of these blocking mAbs. None of these blocking mAbs could bind to thrombin-PN-1 complexes. A mAb (pl-1) which did not block PN-1 activity was capable of binding to these complexes. MAbs pl-9 and pl-18 were used to immunopurify two forms of PN-1 which have different affinities for heparin-Sepharose. These have been referred to as the low heparin affinity and high heparin affinity forms of PN-1 (Scott et al., J. Biol. Chem. 260,7029-7034 [1985]). MAb pl-18 binds only to the high heparin affinity form while mAb pl-9 binds to both forms. Preliminary characterization of this low heparin affinity form reveals no major differences between it and the well characterized high heparin affinity form.
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Hasani, Alireza, and Vahid Tabataba Vakili. "Outage probability improvement of a two-way relay network with MABC DF protocol by joint relay selection and optimal power allocation." In 2016 24th Iranian Conference on Electrical Engineering (ICEE). IEEE, 2016. http://dx.doi.org/10.1109/iraniancee.2016.7585568.

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7

Bini, A., R. Mesa-Tejada, J. Fenoglio, B. Kudryk, and K. L. Kaplan. "SPECIFIC DETECTION OF FIBRIN IN HUMAN TISSUES BY A NEW IMMUNOHISTOCHEMICAL TECHNIQUE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643316.

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Human biopsy (30), surgical (50) and autopsy (14) specimens of different embryonic origin (skin, blood vessel, kidney, lymph nodes, prostate, lung, liver, and intestine) were stained by the avidin-biotin complex immunoperoxidase technique (ABC-IP) with monoclonal antibodies (MAbs). MAb T2G1 (recognizes 315-42 and detects fibrin II in tissues), MAb I8C6 (recognizes BS1-42 and indicates fibrinogen and fibrin I), MAb GC4 (specific for fragments D and D-D), and a polyclonal antiserum for fibrinogen. The method can be applied to frozen or Boilin’s fixed paraffin embedded tissues with good preservation of morphology and high sensitivity at the light microscopy level. The results were compared with conventional histochemical stains currently used in surgical pathology to demonstrate fibrin deposits in tissues. These stains are based on the acidophilic properties of fibrin (Fraser-Lendrum for “more recent” and Mallory’s PTAH for “older” fibrin). ABC-IP staining with MAb T2G1 clearly detected fibrin in areas where Lendrum and PTAH failed to reveal fibrin deposits, e.g., in the intercellular and pericellular matrix, as well as in areas where staining occurred with conventional techniques, indicating greater sensitivity of the ABC-IP method. Fibrin was specifically detected in strands or clumps in some areas of inflammation and granulation tissue and seemed to be associated with platelets and macrophages. Moreover, ABC-IP with MAb I8C6 and MAb GC4 permits the distinction between fibrinogen or fibrin I, and D and D dimer which are poorly reactive with the Lendrum and PTAH methods. The polyclonal antiserum for fibrinogen showed reactivity with all the material stained with the MAbs and with some additional areas due to the epitopes of fibrinogen and fibrin not detected by the monoclonals. The ABC-IP technique with MAbs allows specific demonstration of fibrin deposits in tissues. Moreover, these results indicate that this method facilitates the correlation of the morphologic appearance of fibrinogen) -related deposits in tissues with their molecular form and will be useful to elucidate the role of fibrin in diseases such as atherosclerosis, kidney disease, and tumors.
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8

Takahashi, Y., J. P. Girma, M. Kalafatis, K. Sewerin, L. O. Andersson, and D. Meyer. "LOCALIZATION OF A FACTOR VIII BINDING DOMAIN ON THE N-TERMINAL PORTION (FRAGMENT SpIII) OF VON WILLEBRAND FACTOR." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642876.

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A new domain has been identified on the von Willebrand Factor (vWF) subunit. vWF binds to platelet glycoproteins GPIb and GPIIb/IIIa as well as to collagen and corresponding domains have been isolated. vWF also binds to Factor VIII (F.VIII). We show here that the corresponding domain is located on the N-terminal portion of the vWF subunit (residues 1 to 1,365). For this purpose, F.VIII was tested for its ability to bind to purified vWF degradation fragments obtained by digestion with S.aureus V-8 protease, ie a dimeric N-terminal fragment of 320 kd (SpIII) and a dimeric C-terminal fragment of 220 kd (SpII). Human F.VIII was purified from cryoprecipitate by immunoadsorption of F.VIII/vWF onto a monoclonal antibody (MAb) to vWF coupled to Sepharose, followed by elution using 0.25 M CaCl2. The F.VIII preparation contained 100 U/ml VIII:C and less than 0.001 XJ/ml vWFAg. The binding assay was performed using polystyrene tubes coated with 2 ug/ml of purified vWF, SpIII or SpII. Coated albumin, fibrinogen or fibronectin were used as controls. Purified F.VIII (0.1 to 2 U/ml VIII:C) was incubated in the coated tubes for 1 h at 37°C. Following washing, bound F.VIII was estimated in situ by one-stage clotting and chromogenic assays. Immunoradiometric assay with 125 I-MAbs to SpII or SpIII demonstrated that the amount of coated protein remained constant throughout the experiments. F.VIII bound in a dose-dependent manner to coated vWF and SpIII but not to SpII. Binding was specific for F.VIII as demonstrated by inhibition experiments. Bound F.VIII could be removed with 0.25 M CaCl2 and its coagulant activity inhibited by a MAb or an oligoclonal (homologous) antibody neutralising VIII:C. Binding of F.VIII to coated vWF or SpIII was also inhibited in a dose-dependent way by vWF or SpIII. In contrast, addition of SpII had no effect upon the binding. Binding of F.VIII to SpIII was confirmed using MAbs to vWF. Among 28 MAbs which bound SpIII and had no anti VIII:C activity, 12 inhibited binding of F.VIII whereas the others had no effect. Among the latter, 3 MAbs blocked binding of vWF or SpIII to GPIb and 6 MAbs inhibited binding of vWF or SpIII to collagen. Ten MAbs to SpII had no inhibitory effect upon binding of F.VIII. These results indicate that a F.VIII binding domain of vWF is located in the N-terminal portion of vWF (residues 1 to 1,365) and that it is distinct from the GPIb and collagen binding domains. The 12 MAbs to SpIII which block binding of F.VIII to vWF or SpIII should allow the precise localization of this new domain.
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9

Abbink, J., J. Nuijens, C. Huijbregts, and E. Hack. "DETECTION OF INACTIVATED α2-MACROGLOBULIN (α2M) IN HUMAN PLASMA USING MONOCLONAL ANTIBODIES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643865.

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Monoclonal antibodies (mAbs) were raised against human a2M. Five mAbs that bound to α2M in ELISA were further analyzed by a radioimmunoassay (RIA) for their reaction with three types of α2M: native α2M, chemically inactivated α2M (iα2M) (methylamine treated), and proteolytically iα2M. One mAb reacted with all forms of α2M, while four mAbs bound both forms of ia2M but not native α2M. One of these latter mAbs (Ml) was used to develop a RIA (the Ml-assay) for the detection of iα2M in plasma: Ml coupled to Sepharose is incubated with the plasma to be tested, and bound iα2M is detected by a subsequent incubation with polyclonal 125I-anti-α2M antibodies. As little as 5 ng of iα2M can be detected with this assay in the presence of an excess of native α2M. This assay was then applied to measure inactivation of α2M in vitro and in vivo. In vitro activation of the contact system in plasma by dextran sulfate results in the inactivation of ca 10% of α2M. When blood from normal donors was collected under optimal conditions, about 0.5% of the total α2M content appeared to be iα2M. Longitudinal studies in patients (a.o. with septicaemie, during cardiopulmunary bypass) revealed that increased levels of iα2M occurred sporadically. The Ml-assay appears to be useful to monitor the role of α2M in human diseases.
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Rathjen, Deborah A., and Carolyn L. Geczy. "PRODUCTION AND CHARACTERISATION OF A MONOCLONAL ANTIBODY AGAINST HUMAN ANTI-THROMBIN III." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644358.

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To study the role of anticoagulants, particularly antithrombin III (AT III) and heparin, on the activation of coagulation by monocytes/macrophages which have been stimulated with a soluble lymphocyte activation product, macrophage procoagulant inducing factor, we have prepared monoclonal antibodies (MAbs) to human AT III.In fusion experiments, in contrast to wells containing peritoneal feeder cells, positive hybrids were only found in wells containing medium conditioned by the macrophage cell line J774 (Rathjen and Geczy, 1986). Of 5 hybrids which initially produced antibody, only one hybrid, showed stable Ab production. The MAb, designated 22/23, was not cross-reactive with either 1 antitrypsin or ovalbumin and did not inhibit the biological activity of AT III in chromogenic assays which measured inhibition of thrombin and Factor Xa by AT III. An immunoadsorbent prepared using MAb 22/23 depleted AT III activity from a purified AT III preparation. Reduction and alkylat ion of the disulphide bonds of the protein portion of AT III completely abbrogated MAb binding indicating that the native configuration of AT III was important. Isoelectric focussing of AT III, followed by transfer of the focussed protein to nitrocellulose by diffusion and probing with MAb 22/23, revealed at least 8 bands in the region of pH 5.2 to 5.85. Coomassie blue staining of a gel run in parallel showed 9 bands in this region. The MAb provides a useful tool for the detection of AT III on both cultured cells (bovine aortic endothelial cells are positive by immunofluorescence) and tissue sections.Rathjen, D.A. and Geczy, C.L. Hybridomo. 5s 255-261 (1986)
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Reports on the topic "MABC"

1

Guenther, R. The Application/MARC Content-type. RFC Editor, October 1997. http://dx.doi.org/10.17487/rfc2220.

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2

Toney, Gary W. MARC Data Collection- A Flawed Process. Fort Belvoir, VA: Defense Technical Information Center, March 2008. http://dx.doi.org/10.21236/ada479621.

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3

Radoslavov, P., D. Estrin, R. Govindan, M. Handley, S. Kumar, and D. Thaler. The Multicast Address-Set Claim (MASC) Protocol. RFC Editor, September 2000. http://dx.doi.org/10.17487/rfc2909.

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4

Whiting, D., R. Housley, and N. Ferguson. Counter with CBC-MAC (CCM). RFC Editor, September 2003. http://dx.doi.org/10.17487/rfc3610.

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5

Russell, V. K. MAC, material accounting database user guide. Office of Scientific and Technical Information (OSTI), September 1994. http://dx.doi.org/10.2172/10104854.

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Russell, V. K. Cleanup MAC and MBA code ATP. Office of Scientific and Technical Information (OSTI), October 1994. http://dx.doi.org/10.2172/10192501.

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7

Tsiang, D., and G. Suwala. The Cisco SRP MAC Layer Protocol. RFC Editor, August 2000. http://dx.doi.org/10.17487/rfc2892.

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8

Smid, Miles E., Elaine Barker, David Balenson, and Martha Haykin. Message authentication code (MAC) validation system. Gaithersburg, MD: National Bureau of Standards, 1988. http://dx.doi.org/10.6028/nbs.sp.500-156.

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9

Wade, J. A. Lithostratigraphy 4: Mic Mac and Abenaki formations. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1991. http://dx.doi.org/10.4095/210641.

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10

Nettles, Scott. Evaluating Mima-Mac For Dense Urban Environments. Fort Belvoir, VA: Defense Technical Information Center, January 2007. http://dx.doi.org/10.21236/ada462309.

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