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Journal articles on the topic 'Macaques, rhesus'

Author: Grafiati

Published: 4 June 2021

Last updated: 29 July 2025

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1

Reimann, Keith A., Robert A. Parker, Michael S. Seaman, et al. "Pathogenicity of Simian-Human Immunodeficiency Virus SHIV-89.6P and SIVmac Is Attenuated in Cynomolgus Macaques and Associated with Early T-Lymphocyte Responses." Journal of Virology 79, no. 14 (2005): 8878–85. http://dx.doi.org/10.1128/jvi.79.14.8878-8885.2005.

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ABSTRACT Because most studies of AIDS pathogenesis in nonhuman primates have been performed in Indian-origin rhesus macaques (Macaca mulatta), little is known about lentiviral pathogenicity and control of virus replication following infection of alternative macaque species. Here, we report the consequences of simian-human immunodeficiency virus SHIV-89.6P and SIVmac251 infection in cynomolgus (Macaca fascicularis) and rhesus macaques of Chinese origin. Compared to the pathogenicity of the same viruses in Indian rhesus macaques, both cynomolgus and Chinese rhesus macaques showed lower levels of

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2

Williamson, E. D., I. Hodgson, N. J. Walker, et al. "Immunogenicity of Recombinant Protective Antigen and Efficacy against Aerosol Challenge with Anthrax." Infection and Immunity 73, no. 9 (2005): 5978–87. http://dx.doi.org/10.1128/iai.73.9.5978-5987.2005.

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ABSTRACT Immunization with a recombinant form of the protective antigen (rPA) from Bacillus anthracis has been carried out with rhesus macaques. Rhesus macaques immunized with 25 μg or more of B. subtilis-expressed rPA bound to alhydrogel had a significantly increased immunoglobulin G (IgG) response to rPA compared with macaques receiving the existing licensed vaccine from the United Kingdom (anthrax vaccine precipitated [AVP]), although the isotype profile was unchanged, with bias towards the IgG1 and IgG2 subclasses. Immune macaque sera from all immunized groups contained toxin-neutralizing

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3

Su, Qian, Yongfang Yao, Qin Zhao, et al. "Genetic diversity and phylogenetic analyses of 11 cohorts of captive rhesus macaques from Chinese zoos." PeerJ 7 (May 29, 2019): e6957. http://dx.doi.org/10.7717/peerj.6957.

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Rhesus macaques are raised in almost every Chinese zoo due to their likeability and ease in feeding; however, little is yet known about the genetic diversity of rhesus macaques in captivity. In this study, a 475-base pair nucleotide sequence of the mitochondrial DNA control region was obtained from the fecal DNA of 210 rhesus macaque individuals in captivity. A total of 69 haplotypes were defined, 51 of which (73.9%) were newly identified. Of all haplotypes, seven were shared between two zoos, and 62 haplotypes (89.8%) appeared only in a specific zoo, indicating a low rate of animal exchange b

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4

DiVincenti, L., A. Rehrig, and J. Wyatt. "Interspecies pair housing of macaques in a research facility." Laboratory Animals 46, no. 2 (2012): 170–72. http://dx.doi.org/10.1258/la.2011.011134.

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The eighth edition of The Guide for the Care and Use of Laboratory Animals establishes social housing as the ‘default’ for social species including non-human primates. The advantages of social housing for primates have been well established, but small research facilities housing few primates in indoor cages have struggled with social housing as a result of limitations on appropriate housing and availability of compatible monkeys. Here, we report a novel approach to pair housing macaques – crossing species. We have successfully pair housed an intact male rhesus macaque with an intact male cynom

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5

MALAIVIJITNOND, SUCHINDA, OSAMU TAKENAKA, YOSHI KAWAMOTO, NONTAKORN URASOPON, ISLAMUL HADI, and YUZURU HAMADA. "Anthropogenic Macaque Hybridization and Genetic Pollution of a Threatened Population." Tropical Natural History 7, no. 1 (2007): 11–23. https://doi.org/10.58837/tnh.7.1.102915.

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Interspecific matings between one released male pig-tailed macaque and female rhesus macaques were observed in a small isolated semi-wild troop of rhesus macaques in northeastern Thailand. Two of three juvenile males suspected to be hybrids based on their appearance, were caught and examined morphologically and genetically. Both suspected hybrids had a dark brown and anteriorly narrow crown patch and thinly haired tails as are common in pig-tailed macaques, and tail-lengths in the range of rhesus macaque. Male no. 19 showed neither cheek hair whorl nor the bipartite pattern of pelage color cha

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6

COHEN, Ofer, Chanoch KRONMAN, Baruch VELAN, and Avigdor SHAFFERMAN. "Amino acid domains control the circulatory residence time of primate acetylcholinesterases in rhesus macaques (Macaca mulatta)." Biochemical Journal 378, no. 1 (2004): 117–28. http://dx.doi.org/10.1042/bj20031305.

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An array of 13 biochemically well defined molecular forms of bovine, human and newly cloned rhesus macaque (Macaca mulatta) AChEs (acetylcholinesterases) differing in glycosylation and subunit assembly status were subjected to comparative pharmacokinetic studies in mice and rhesus macaques. The circulatory lifetimes of recombinant bovine, macaque and human AChEs in mice were governed by previously determined hierarchical rules; the longest circulatory residence time was obtained when AChE was fully sialylated and tetramerized [Kronman, Chitlaru, Elhanany, Velan and Shafferman (2000) J. Biol. C

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7

Cheney, Dorothy L., Michael J. Owren, Jacquelyn A. Dieter, and Robert M. Seyfarth. "'Food' Calls Produced By Adult Female Rhesus (Macaca Mulatta) and Japanese (M. Fuscata) Macaques, Their Normally-Raised Offspring, and Offspring Cross-Fostered Between Species." Behaviour 120, no. 3-4 (1992): 218–31. http://dx.doi.org/10.1163/156853992x00615.

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AbstractWe tested a recent claim that rhesus and Japanese macaque offspring cross-fostered between species exhibit vocal learning by producing 'food' calls typical of their adoptive rather than their genetic species (MASATAKA & FUJITA, 1989). Our study population consisted of four groups of socially-reared animals housed outdoors - two of each species. Food calls produced by adult female rhesus and Japanese macaques did not differ at the species level, although individual differences were clearly present. Food calls produced by normally raised offspring differed both between individuals an

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8

Smith, Autumn L., Darla H. Black, and R. Eberle. "Molecular Evidence for Distinct Genotypes of Monkey B Virus (Herpesvirus Simiae) Which Are Related to the Macaque Host Species." Journal of Virology 72, no. 11 (1998): 9224–32. http://dx.doi.org/10.1128/jvi.72.11.9224-9232.1998.

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ABSTRACT Although monkey B virus (herpesvirus simiae; BV) is common in all macaque species, fatal human infections appear to be associated with exposure to rhesus macaques (Macaca mulatta), suggesting that BV isolates from rhesus monkeys may be more lethal to nonmacaques than are BV strains indigenous to other macaque species. To determine if significant differences that would support this supposition exist among BV isolates, we compared multiple BV strains isolated from rhesus, cynomolgus, pigtail, and Japanese macaques. Antigenic analyses indicated that while the isolates were very closely r

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9

Matson, Cayman, Nicholas Castle, and Chenkai Dai. "Developing a Virtual Model of the Rhesus Macaque Inner Ear." Bioengineering 11, no. 11 (2024): 1158. http://dx.doi.org/10.3390/bioengineering11111158.

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A virtual model of the rhesus macaque inner ear was created in the present study. Rhesus macaques have been valuable in cochlear research; however, their high cost prompts a need for alternative methods. Finite Element (FE) analysis offers a promising solution by enabling detailed simulations of the inner ear. This study employs FE analysis to create a virtual model of the rhesus macaque’s inner ear, reconstructed from MRI scans, to explore how cochlear implants (CIs) impact residual hearing loss. Harmonic-acoustic simulations of sound wave transmission indicate that CIs have minor effects on

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10

Guan, Yongjun, Mohammad Sajadi, James Robinson, et al. "Genetic similarities and differences in the anti-HIV-1 Env antibody responses between humans and rhesus macaques (105.40)." Journal of Immunology 186, no. 1_Supplement (2011): 105.40. http://dx.doi.org/10.4049/jimmunol.186.supp.105.40.

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Abstract We previously described a method for rapid cloning human monoclonal antibody (mAb) from memory B cell (Bmem). Here, we have put this method in practice for isolating a large panel of mAbs against HIV-1 envelope (Env) protein and have extended it as a general strategy to isolate monkey mAbs against HIV-1 Env from Bmem of a SHIV infected rhesus macaque. Ninety-six new mAbs were cloned from 5 HIV-1 infected humans, of which 64 are clonally unique Env mAbs. Thirty-five mAbs against HIV-1 Env were cloned directly from Bmem or from immortalized Env B cell lines both derived from SHIV infect

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11

Norris, Karen A., Hans Wildschutte, Jennifer Franko, and Kathryn F. Board. "Genetic Variation at the Mitochondrial Large-Subunit rRNA Locus of Pneumocystis Isolates from Simian Immunodeficiency Virus-Infected Rhesus Macaques." Clinical Diagnostic Laboratory Immunology 10, no. 6 (2003): 1037–42. http://dx.doi.org/10.1128/cdli.10.6.1037-1042.2003.

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ABSTRACT The nucleotide sequences of a segment of the Pneumocystis mitochondrial large-subunit (mt LSU) rRNA gene from rhesus macaques coinfected with simian immunodeficiency virus (SIV) and Pneumocystis carinii were examined. Of 12 isolates examined, 3 were found to be identical and the others showed substantial sequence variation, with up to 13% divergence among variants. We identified two general sequence types that differed at several sites, including a conserved 26-nucleotide insertion. Four monkeys had evidence of two Pneumocystis variants present simultaneously, indicative of a mixed in

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12

Kondova, Ivanela, Gerco Braskamp, Peter J. Heidt, et al. "Spontaneous endometriosis in rhesus macaques: evidence for a genetic association with specific Mamu-A1 alleles." Primate Biology 4, no. 1 (2017): 117–25. http://dx.doi.org/10.5194/pb-4-117-2017.

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Abstract. Endometriosis is a poorly understood common debilitating women's reproductive disorder resulting from proliferative and ectopic endometrial tissue associated with variable clinical symptoms including dysmenorrhea (painful menstrual periods), dyspareunia (pain on intercourse), female infertility, and an increased risk of malignant transformation. The rhesus macaque (Macaca mulatta) develops a spontaneous endometriosis that is very similar to that seen in women. We hypothesized that specific major histocompatibility complex (MHC) alleles may contribute to the pathogenesis of endometrio

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13

Patel, Sumit Kumar, Somesh Singh, Meenakshi Dawar, Shobha Jawre, and Amol Rokde. "Haemato-biochemical Profile Assessment of Immobilized Wild Rhesus Macaques (Macaca mulatta) in Jabalpur, India." Journal of Advances in Biology & Biotechnology 28, no. 3 (2025): 136–43. https://doi.org/10.9734/jabb/2025/v28i32076.

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Indian rhesus macaque has been extensively used in biomedical research, particularly in disease studies and drug discovery. Accurate assessment of clinical pathology parameters is crucial for evaluating their health status, particularly in studies involving disease modeling and drug development. However, comprehensive data on hematological and biochemical parameters, especially in wild rhesus macaques, remain limited. Due to increased use of non-human primates in research studies, it is necessary to understand the effect of immobilizing drugs on haemato-biochemical values in wild rhesus macaqu

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14

Kim, Jong J., Joo-Sung Yang, Thomas C. VanCott, et al. "Modulation of Antigen-Specific Humoral Responses in Rhesus Macaques by Using Cytokine cDNAs as DNA Vaccine Adjuvants." Journal of Virology 74, no. 7 (2000): 3427–29. http://dx.doi.org/10.1128/jvi.74.7.3427-3429.2000.

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ABSTRACT An important limitation of DNA immunization in nonhuman primates is the difficulty in generating high levels of antigen-specific antibody responses; strategies to enhance the level of immune responses to DNA immunization may be important in the further development of this vaccine strategy for humans. We approached this issue by testing the ability of molecular adjuvants to enhance the levels of immune responses generated by multicomponent DNA vaccines in rhesus macaques. Rhesus macaques were coimmunized intramuscularly with expression plasmids bearing genes encoding Th1 (interleukin 2

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15

Wong, Scott W., Eric P. Bergquam, Ryan M. Swanson, et al. "Induction of B Cell Hyperplasia in Simian Immunodeficiency Virus–Infected Rhesus Macaques with the Simian Homologue of Kaposi's Sarcoma–Associated Herpesvirus." Journal of Experimental Medicine 190, no. 6 (1999): 827–40. http://dx.doi.org/10.1084/jem.190.6.827.

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A simian homologue of Kaposi's sarcoma–associated herpesvirus (KSHV), the eighth human herpesvirus (HHV8), was isolated from a simian immunodeficiency virus (SIV)-infected rhesus macaque (Macaca mulatta) that developed a multicentric lymphoproliferative disorder (LPD). This simian rhadinovirus is genetically similar to a recently described rhesus rhadinovirus (RRV) (Desrosiers, R.C., V.G. Sasseville, S.C. Czajak, X. Zhang, K.G. Mansfield, A. Kaur, R.P. Johnson, A.A. Lackner, and J.U. Jung. 1997. J. Virol. 71:9764–9769) and is designated RRV 17577. RRV 17577 was experimentally inoculated into r

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16

Novembre, Francis J., Juliette De Rosayro, Shawn P. O’Neil, Daniel C. Anderson, Sherry A. Klumpp, and Harold M. McClure. "Isolation and Characterization of a Neuropathogenic Simian Immunodeficiency Virus Derived from a Sooty Mangabey." Journal of Virology 72, no. 11 (1998): 8841–51. http://dx.doi.org/10.1128/jvi.72.11.8841-8851.1998.

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ABSTRACT Transfusion of blood from a simian immunodeficiency virus (SIV)- and simian T-cell lymphotropic virus-infected sooty mangabey (designated FGb) to rhesus and pig-tailed macaques resulted in the development of neurologic disease in addition to AIDS. To investigate the role of SIV in neurologic disease, virus was isolated from a lymph node of a pig-tailed macaque (designated PGm) and the cerebrospinal fluid of a rhesus macaque (designated ROn2) and passaged to additional macaques. SIV-related neuropathogenic effects were observed in 100% of the pig-tailed macaques inoculated with either

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17

Mansfield, Keith G., Susan V. Westmoreland, Colin D. DeBakker, Susan Czajak, Andrew A. Lackner, and Ronald C. Desrosiers. "Experimental Infection of Rhesus and Pig-Tailed Macaques with Macaque Rhadinoviruses." Journal of Virology 73, no. 12 (1999): 10320–28. http://dx.doi.org/10.1128/jvi.73.12.10320-10328.1999.

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ABSTRACT The recognition of naturally occurring rhadinoviruses in macaque monkeys has spurred interest in their use as models for human infection with Kaposi sarcoma-associated herpesvirus (human herpesvirus 8). Rhesus macaques (Macaca mulatta) and pig-tailed macaques (Macaca nemestrina) were inoculated intravenously with rhadinovirus isolates derived from these species (rhesus rhadinovirus [RRV] and pig-tailed rhadinovirus [PRV]). Nine rhadinovirus antibody-negative and two rhadinovirus antibody-positive monkeys were used for these experimental inoculations. Antibody-negative animals clearly

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18

Orlova, Nina, Mark H. Fogg, Angela Carville, and Fred Wang. "Antibodies to Lytic Infection Proteins in Lymphocryptovirus-Infected Rhesus Macaques: a Model for Humoral Immune Responses to Epstein-Barr Virus Infection." Clinical and Vaccine Immunology 18, no. 9 (2011): 1427–34. http://dx.doi.org/10.1128/cvi.05126-11.

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ABSTRACTHumoral immune responses to rhesus lymphocryptovirus (rhLCV) lytic infection proteins were evaluated in the rhesus macaque animal model for Epstein-Barr virus (EBV) infection. We found a hierarchy of humoral responses to 14 rhLCV lytic infection proteins in naturally infected rhesus macaques, with (i) widespread and robust responses to four glycoproteins expressed as late proteins, (ii) frequent but less robust responses to a subset of early proteins, and (iii) low-level responses to immediate-early proteins. This hierarchy of humoral responses was similar to that reported for EBV-infe

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19

Allen, Todd M., John Sidney, Marie-France del Guercio, et al. "Characterization of the Peptide Binding Motif of a Rhesus MHC Class I Molecule (Mamu-A*01) That Binds an Immunodominant CTL Epitope from Simian Immunodeficiency Virus." Journal of Immunology 160, no. 12 (1998): 6062–71. http://dx.doi.org/10.4049/jimmunol.160.12.6062.

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Abstract The majority of immunogenic CTL epitopes bind to MHC class I molecules with high affinity. However, peptides longer or shorter than the optimal epitope rarely bind with high affinity. Therefore, identification of optimal CTL epitopes from pathogens may ultimately be critical for inducing strong CTL responses and developing epitope-based vaccines. The SIV-infected rhesus macaque is an excellent animal model for HIV infection of humans. Although a number of CTL epitopes have been mapped in SIV-infected rhesus macaques, the optimal epitopes have not been well defined, and their anchor re

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Zhang, Qingxun, Shuyi Han, Kongshang Liu, Jing Luo, Jiqi Lu, and Hongxuan He. "Occurrence of Selected Zoonotic Fecal Pathogens and First Molecular Identification of Hafnia paralvei in Wild Taihangshan Macaques (Macaca mulatta tcheliensis) in China." BioMed Research International 2019 (April 3, 2019): 1–7. http://dx.doi.org/10.1155/2019/2494913.

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Rhesus macaques (Macaca mulatta) are hosts to a range of zoonotic and potentially zoonotic pathogens. The present study firstly provides a broader investigation of the presence and prevalence of zoonotic fecal pathogens in wild Taihangshan macaques, a subspecies of rhesus macaque in China. A total of 458 fecal samples were collected between September 2015 and November 2016. Fourteen genera of intestinal parasites (four genera of protozoans and ten genera of helminths) and twelve genera of bacteria were tested for using PCR amplification. The overall samples prevalence of parasitic infection wa

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Maestripieri, Dario. "Mother-Infant Relationships in Three Species of Macaques (Macaca Mulatta, M. Nemestrina, M. Arctoides). I. Development of the Mother-Infant Relationship in the First Three Months." Behaviour 131, no. 1-2 (1994): 75–96. http://dx.doi.org/10.1163/156853994x00226.

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AbstractThis study compared mother-infant relationships in rhesus, pigtail, and stumptail macaques living in large captive social groups. Mother-infant pairs were focally observed in 4 weekly 30-min sessions for the first 12 weeks of infant life. Rhesus and stumptail infants were active earlier than pigtail infants, and rhesus mothers further encouraged infant independence by frequently breaking contact with them and rejecting them. Rhesus mothers also restrained their infants, presumably in circumstances where a danger for them was perceived. Pigtail mothers were more protective than rhesus m

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Dudley, Dawn M., Matthew T. Aliota, Emma L. Mohr, et al. "Using Macaques to Address Critical Questions in Zika Virus Research." Annual Review of Virology 6, no. 1 (2019): 481–500. http://dx.doi.org/10.1146/annurev-virology-092818-015732.

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Zika virus (ZIKV) and nonhuman primates have been inextricably linked since the virus was first discovered in a sentinel rhesus macaque in Uganda in 1947. Soon after ZIKV was epidemiologically associated with birth defects in Brazil late in 2015, researchers capitalized on the fact that rhesus macaques are commonly used to model viral immunity and pathogenesis, quickly establishing macaque models for ZIKV infection. Within months, the susceptibility of pregnant macaques to experimental ZIKV challenge and ZIKV-associated abnormalities in fetuses was confirmed. This review discusses key unanswer

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Johnston, Sara C., Keersten M. Ricks, Alexandra Jay, et al. "Development of a coronavirus disease 2019 nonhuman primate model using airborne exposure." PLOS ONE 16, no. 2 (2021): e0246366. http://dx.doi.org/10.1371/journal.pone.0246366.

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Airborne transmission is predicted to be a prevalent route of human exposure with SARS-CoV-2. Aside from African green monkeys, nonhuman primate models that replicate airborne transmission of SARS-CoV-2 have not been investigated. A comparative evaluation of COVID-19 in African green monkeys, rhesus macaques, and cynomolgus macaques following airborne exposure to SARS-CoV-2 was performed to determine critical disease parameters associated with disease progression, and establish correlations between primate and human COVID-19. Respiratory abnormalities and viral shedding were noted for all anim

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Wu, Fan, Andrea Kirmaier, Ellen White та ін. "TRIM5α Resistance Escape Mutations in the Capsid Are Transferable between Simian Immunodeficiency Virus Strains". Journal of Virology 90, № 24 (2016): 11087–95. http://dx.doi.org/10.1128/jvi.01620-16.

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ABSTRACT TRIM5α polymorphism limits and complicates the use of simian immunodeficiency virus (SIV) for evaluation of human immunodeficiency virus (HIV) vaccine strategies in rhesus macaques. We previously reported that the TRIM5α-sensitive SIV from sooty mangabeys (SIVsm) clone SIVsmE543-3 acquired amino acid substitutions in the capsid that overcame TRIM5α restriction when it was passaged in rhesus macaques expressing restrictive TRIM5α alleles. Here we generated TRIM5α-resistant clones of the related SIVsmE660 strain without animal passage by introducing the same amino acid capsid substituti

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Miller, Christopher J., Marta Marthas, Jennifer Greenier, Ding Lu, Peter J. Dailey, and Yichen Lu. "In Vivo Replication Capacity Rather Than In Vitro Macrophage Tropism Predicts Efficiency of Vaginal Transmission of Simian Immunodeficiency Virus or Simian/Human Immunodeficiency Virus in Rhesus Macaques." Journal of Virology 72, no. 4 (1998): 3248–58. http://dx.doi.org/10.1128/jvi.72.4.3248-3258.1998.

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ABSTRACT We used the rhesus macaque model of heterosexual human immunodeficiency virus (HIV) transmission to test the hypothesis that in vitro measures of macrophage tropism predict the ability of a primate lentivirus to initiate a systemic infection after intravaginal inoculation. A single atraumatic intravaginal inoculation with a T-cell-tropic molecular clone of simian immunodeficiency virus (SIV), SIVmac239, or a dualtropic recombinant molecular clone of SIV, SIVmac239/1A11/239, or uncloned dualtropic SIVmac251 or uncloned dualtropic simian/human immunodeficiency virus (SHIV) 89.6-PD produ

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Herrman, Marissa, Janine Mühe, Carol Quink, and Fred Wang. "Epstein-Barr Virus gp350 Can Functionally Replace the Rhesus Lymphocryptovirus Major Membrane Glycoprotein and Does Not Restrict Infection of Rhesus Macaques." Journal of Virology 90, no. 3 (2015): 1222–30. http://dx.doi.org/10.1128/jvi.02531-15.

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ABSTRACTPrimary Epstein-Barr virus (EBV) infection is the most common cause of infectious mononucleosis, and persistent infection is associated with multiple cancers. EBV vaccine development has focused on the major membrane glycoprotein, gp350, since it is the major target for antibodies that neutralize infection of B cells. However, EBV has tropism for both B cells and epithelial cells, and it is unknown whether serum neutralizing antibodies against B cell infection will provide sufficient protection against virus infection initiated at the oral mucosa. This could be stringently tested by pa

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Hasan, Md Mahedi, and Md Azizul Hakim. "Diet, Feeding Habit and Behavioral Activity of Rhesus Macaque (Macaca mulatta) at Charmuguria of Madaripur, Bangladesh." Jagannath University Journal of Life and Earth Sciences 9, no. 2 (2024): 147–62. http://dx.doi.org/10.3329/jnujles.v9i2.72921.

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Diet, feeding habits, and behavioral activities of Rhesus macaque (Macaca Mulatta) were studied at Charmuguria of Madaripur district from March 2021 to December 2021. Among the five troops, one troop with four age-sex individuals was selected for data collection. Scan sampling methods at 10-minute intervals were used for data collection. Rhesus macaque spent 72% of feeding time on natural foods and 28% on provisioned foods. During the study period, 11 types of provisioned foods were recorded as a diet of Rhesus macaque, of which 73% were unprocessed food, and 27% were processed food. Rhesus ma

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Gardner, Matthew R., Christoph H. Fellinger, Lisa M. Kattenhorn, et al. "AAV-delivered eCD4-Ig protects rhesus macaques from high-dose SIVmac239 challenges." Science Translational Medicine 11, no. 502 (2019): eaau5409. http://dx.doi.org/10.1126/scitranslmed.aau5409.

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A number of simian and simian human immunodeficiency viruses (SIV and SHIV, respectively) have been used to assess the efficacy of HIV-1 vaccine strategies. Among these, SIVmac239 is considered among the most stringent because, unlike SHIV models, its full genome has coevolved in its macaque host and its tier 3 envelope glycoprotein (Env) is exceptionally hard to neutralize. Here, we investigated the ability of eCD4-Ig, an antibody-like entry inhibitor that emulates the HIV-1 and SIV receptor and coreceptor, to prevent SIVmac239 infection. We show that rh-eCD4-IgI39N expressed by recombinant a

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Maestripieri, Dario. "Mother-Infant Relationships in Three Species of Macaques (Macaca Mulatta, M. Nemestrina, M. Arctoides). Ii. the Social Environment." Behaviour 131, no. 1-2 (1994): 97–113. http://dx.doi.org/10.1163/156853994x00235.

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AbstractThis study compared social interactions between mothers, infants, and other group members in rhesus, pigtail, and stumptail macaques living in large captive social groups. Mother-infant pairs were focally observed in 4 weekly 30-min sessions for the first 12 weeks of infant life. Rhesus and pigtail mothers were remarkably similar in several contact, proximity, and grooming measures, but their scores were lower than those of stumptail mothers. The three species did not differ quantitatively in interest shown in infants by other group members, as measured by infant handling and grooming.

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Kaur, Amitinder, Robert M. Grant, Robert E. Means, Harold McClure, Mark Feinberg, and R. Paul Johnson. "Diverse Host Responses and Outcomes following Simian Immunodeficiency Virus SIVmac239 Infection in Sooty Mangabeys and Rhesus Macaques." Journal of Virology 72, no. 12 (1998): 9597–611. http://dx.doi.org/10.1128/jvi.72.12.9597-9611.1998.

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ABSTRACT Sooty mangabeys naturally infected with simian immunodeficiency virus (SIV) do not develop immunodeficiency despite the presence of viral loads of 105 to 107 RNA copies/ml. To investigate the basis of apathogenic SIV infection in sooty mangabeys, three sooty mangabeys and three rhesus macaques were inoculated intravenously with SIVmac239 and evaluated longitudinally for 1 year. SIVmac239 infection of sooty mangabeys resulted in 2- to 4-log-lower viral loads than in macaques and did not reproduce the high viral loads observed in natural SIVsmm infection. During acute SIV infection, pol

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Peng, Xinxia, Chul-Woo Pyo, Matthew Thomas, et al. "Quantitative expression analysis of rhesus macaque MHC alleles (APP3P.102)." Journal of Immunology 194, no. 1_Supplement (2015): 113.3. http://dx.doi.org/10.4049/jimmunol.194.supp.113.3.

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Abstract The relevance of MHC genes to HIV infection and disease progression is well established, and nonhuman primates are the most important model for AIDS vaccine research and development. However, due to the structural and sequence complexity of the macaque MHC, the expression changes across this complex region have not been determined accurately. We are developing a strategy for accurately quantifying rhesus MHC allele expression. Our strategy leverages a large collection of full-length rhesus MHC genomic sequences and a custom-developed computational pipeline, and only requires regular m

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Rucksaken, Rucksak, Supakarn Kaewchot, Thitichai Jarudecha, et al. "Molecular Detection and Characterization of Hemotropic Mycoplasma in Assamese Macaques (Macaca assamensis) of Northern Thailand." Veterinary Medicine International 2024 (May 13, 2024): 1–7. http://dx.doi.org/10.1155/2024/5539938.

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Hemotropic mycoplasmas, also known as hemoplasmas, are parasitic bacteria that infect red blood cells, potentially leading to varying degrees of anemia across numerous mammalian species, including nonhuman primates. The present study aims to investigate the prevalence of hemoplasma infection and identify the species involved among free-ranging Assamese macaques (Macaca assamensis) inhabiting northern Thailand. A total of 133 blood samples were collected from Assamese macaques in Chiang Rai province, Thailand, and subjected to screening for hemoplasma infection utilizing nested PCR amplificatio

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Sultana, Rukshana. "Status and distribution of Rhesus Macaque, Macaca mulatta in metropolitan Dhaka City." Journal of the Asiatic Society of Bangladesh, Science 38, no. 2 (2013): 175–81. http://dx.doi.org/10.3329/jasbs.v38i2.15606.

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A field study was conducted on the status and distribution of the population of rhesus macaque, Macaca mulatta (monkeys) between June 2005 to September 2005. The population survey was made in 10 study sites of old Dhaka city employing transect census technique. I found a total of 178 rhesus macaques ranging in 10 individual troops in old part of Dhaka city. A good number of rhesus population was noted in three places, among them the highest population was seen in Shadhana Awshadhalaya Factory area (59 individuals) and the lowest was (4 individuals) in Radhika Mohan Bosak lane. Population study

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Wooddell, Lauren J., Brianne A. Beisner, Amy C. Nathman, et al. "Sex Differences in Hierarchical Stability in a Formation of a Mixed-sex Group of Rhesus Macaques." Journal of the American Association for Laboratory Animal Science 61, no. 1 (2022): 67–74. http://dx.doi.org/10.30802/aalas-jaalas-21-000067.

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Forming groups of captive rhesus macaques (Macaca mulatta) is a common management practice. New formations of unfamiliar macaques can be costly, with high levels of trauma, particularly as intense aggression is used to establish a dominance hierarchy. Combining previous subgroups into one new group may be beneficial, as some individuals already have established dominance relationships. We tested this hypothesis by forming a new mixed-sex group of rhesus macaques that combined an established group of females with an established group of males. Prior to the mixed-sex group formation, both the fe

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Singh, V., and M. L. Thakur. "Rhesus macaque and associated problems in Himachal Pradesh - India." Taprobanica 4, no. 2 (2012): 112–16. http://dx.doi.org/10.47605/tapro.v4i2.80.

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Conflict between humans and primates is common and increasing. Of the nearly 225 living species of nonhuman primates, three Indian species (i.e., rhesus macaque (Macaca mulatta), bonnet macaque (Macaca radiata) and the hanuman langur (Semnopithecus entellus) have become urbanized. Out of these, rhesus macaques and hanuman langur share food and space with humans in rural and urban areas and are often reported in conflict with humans. Conflicts often occur when these primates raid crops of farmers

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Dudley, Dawn M., Jennifer L. Wentzel, Matthew S. Lalonde, Ronald S. Veazey, and Eric J. Arts. "Selection of a Simian-Human Immunodeficiency Virus Strain Resistant to a Vaginal Microbicide in Macaques." Journal of Virology 83, no. 10 (2009): 5067–76. http://dx.doi.org/10.1128/jvi.00055-09.

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ABSTRACT PSC-RANTES binds to CCR5, inhibits human immunodeficiency virus type 1 (HIV-1) entry, and has been shown as a vaginal microbicide to protect rhesus macaques from a simian-human immunodeficiency virus chimera (SHIVSF162-p3) infection in a dose-dependent manner. In this study, env gene sequences from SHIVSF162-p3-infected rhesus macaques treated with PSC-RANTES were analyzed for possible drug escape variants. Two specific mutations located in the V3 region of gp120 (K315R) and C-helical domain of gp41 (N640D) were identified in a macaque (m584) pretreated with a 100 μM dose of PSC-RANTE

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Li, Di Yan, Yong Fang Yao, An Chun Cheng, et al. "Genetic Differentiation and Systematic Evolution of Sichuan Rhesus Macaques." Advanced Materials Research 343-344 (September 2011): 683–89. http://dx.doi.org/10.4028/www.scientific.net/amr.343-344.683.

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The rhesus macaque (Macaca mulatta) is perhaps the most widely distributed nonhuman primate, is used more extensively than any other primate species as animal models for the study of biomedicine. In this study, we sequenced and analysed a fragment of 491 bp of mitochondrial DNA (mtDNA) partial control region in 230 individuals belonging to 8 populations of Sichuan province of China. Among the 230 individuals, we observed 56 different haplotypes defined by 110 polymorphic sites. The average number of nucleotide differences (k) was 18.844, indicating that very high genetic differentiation and th

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Breed, Matthew W., Samra E. Elser, Workineh Torben, et al. "Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif." Journal of Virology 89, no. 20 (2015): 10156–75. http://dx.doi.org/10.1128/jvi.01134-15.

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ABSTRACTDeletion of Gly-720 and Tyr-721 from a highly conserved GYxxØ trafficking signal in the SIVmac239 envelope glycoprotein cytoplasmic domain, producing a virus termed ΔGY, leads to a striking perturbation in pathogenesis in rhesus macaques (Macaca mulatta). Infected macaques develop immune activation and progress to AIDS, but with only limited and transient infection of intestinal CD4+T cells and an absence of microbial translocation. Here we evaluated ΔGY in pig-tailed macaques (Macaca nemestrina), a species in which SIVmac239 infection typically leads to increased immune activation and

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Ganguly, Ishita, and Netrapal Singh Chauhan. "Daily behavioural activity patterns and reproductive ecology of urban rhesus macaques (Macaca mulatta) in human dominated landscape and its implication in management." Journal of Applied and Natural Science 10, no. 4 (2018): 1101–8. http://dx.doi.org/10.31018/jans.v10i4.1886.

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We observed behavioural activity patterns, daily movements and reproductive ecology (birth rate, death rate, breeding seasons, mating) of urban rhesus macaques (Macaca mulatta) in man-made environment after their reintroduction in Asola-Bhatti Wildlife Sanctuary, Delhi, India using instantaneous sampling or scan sampling method. The daily activity patterns of rhesus macaques inhabiting in the sanctuary were observed from 6:00 h to 18:00 hrs per day from March 2016 to June 2017. The percentage of each activity was estimated quantitatively and birth rate per female per troop in a year was calcul

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Wu, Kun-Chao, Ji-Neng Lv, Hui Yang, et al. "Nonhuman Primate Model of Oculocutaneous Albinism with TYR and OCA2 Mutations." Research 2020 (March 11, 2020): 1–11. http://dx.doi.org/10.34133/2020/1658678.

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Human visual acuity is anatomically determined by the retinal fovea. The ontogenetic development of the fovea can be seriously hindered by oculocutaneous albinism (OCA), which is characterized by a disorder of melanin synthesis. Although people of all ethnic backgrounds can be affected, no efficient treatments for OCA have been developed thus far, due partly to the lack of effective animal models. Rhesus macaques are genetically homologous to humans and, most importantly, exhibit structures of the macula and fovea that are similar to those of humans; thus, rhesus macaques present special advan

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Larochelle, Andre, Michael Savona, Michael Wiggins, et al. "Human and rhesus macaque hematopoietic stem cells cannot be purified based only on SLAM family markers." Blood 117, no. 5 (2011): 1550–54. http://dx.doi.org/10.1182/blood-2009-03-212803.

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Abstract Various combinations of antibodies directed to cell surface markers have been used to isolate human and rhesus macaque hematopoietic stem cells (HSCs). These protocols result in poor enrichment or require multiple complex steps. Recently, a simple phenotype for HSCs based on cell surface markers from the signaling lymphocyte activation molecule (SLAM) family of receptors has been reported in the mouse. We examined the possibility of using the SLAM markers to facilitate the isolation of highly enriched populations of HSCs in humans and rhesus macaques. We isolated SLAM (CD150+CD48−) an

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Loffredo, John T., Jess Maxwell, Ying Qi, et al. "Mamu-B*08-Positive Macaques Control Simian Immunodeficiency Virus Replication." Journal of Virology 81, no. 16 (2007): 8827–32. http://dx.doi.org/10.1128/jvi.00895-07.

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ABSTRACT Certain major histocompatibility complex (MHC) class I alleles are associated with the control of human immunodeficiency virus and simian immunodeficiency virus (SIV) replication. We have designed sequence-specific primers for detection of the rhesus macaque MHC class I allele Mamu-B*08 by PCR and screened a cohort of SIV-infected macaques for this allele. Analysis of 196 SIVmac239-infected Indian rhesus macaques revealed that Mamu-B*08 was significantly overrepresented in elite controllers; 38% of elite controllers were Mamu-B*08 positive compared to 3% of progressors (P = 0.00001).

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Mansfield, Keith G., Angela Carville, Daniel Hebert, et al. "Localization of Persistent Enterocytozoon bieneusiInfection in Normal Rhesus Macaques (Macaca mulatta) to the Hepatobiliary Tree." Journal of Clinical Microbiology 36, no. 8 (1998): 2336–38. http://dx.doi.org/10.1128/jcm.36.8.2336-2338.1998.

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Enterocytozoon bieneusi is the most common microsporidian parasite recognized in human patients with AIDS. Recently, we identified a virtually identical organism causing a spontaneous infection associated with hepatobiliary and intestinal disease in simian immunodeficiency virus (SIV)-infected macaques. To examine the natural history of the infection, we examined captive rhesus macaques for E. bieneusi by PCR, in situ hybridization, and cytochemical techniques. PCR performed on fecal DNA detected enterocytozoon infection in 22 (16.7%) of 131 normal rhesus macaques (Macaca mulatta), compared to

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Deng, Wei, Linlin Bao, Jiangning Liu, et al. "Primary exposure to SARS-CoV-2 protects against reinfection in rhesus macaques." Science 369, no. 6505 (2020): 818–23. http://dx.doi.org/10.1126/science.abc5343.

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Coronavirus disease 2019 (COVID-19), which is caused by infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic. It is unclear whether convalescing patients have a risk of reinfection. We generated a rhesus macaque model of SARS-CoV-2 infection that was characterized by interstitial pneumonia and systemic viral dissemination mainly in the respiratory and gastrointestinal tracts. Rhesus macaques reinfected with the identical SARS-CoV-2 strain during the early recovery phase of the initial SARS-CoV-2 infection did not show detectable viral di

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Markowitz, Martin, Agegnehu Gettie, Leslie St. Bernard, et al. "Once-Weekly Oral Dosing of MK-8591 Protects Male Rhesus Macaques From Intrarectal Challenge With SHIV109CP3." Journal of Infectious Diseases 221, no. 9 (2019): 1398–406. http://dx.doi.org/10.1093/infdis/jiz271.

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Abstract Background MK-8591 (4′-ethynyl-2-fluoro-2′-deoxyadenosine [EFdA]) is a novel reverse transcriptase–translocation inhibitor. Methods We assessed MK-8591 as preexposure prophylaxis in the rhesus macaque model of intrarectal challenge with simian/human immunodeficiency virus (SHIV). In study 1, 8 rhesus macaques received 3.9 mg/kg of MK-8591 orally on day 0 and once weekly for the next 14 weeks. Eight controls were treated with vehicle. All rhesus macaques were challenged with SHIV109CP3 on day 6 and weekly for up to 12 challenges or until infection was confirmed. The dose of MK-8591 was

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Lü, F. Xusheng, Zhongmin Ma, Tracy Rourke, Seema Srinivasan, Michael McChesney, and Christopher J. Miller. "Immunoglobulin Concentrations and Antigen-Specific Antibody Levels in Cervicovaginal Lavages of Rhesus Macaques Are Influenced by the Stage of the Menstrual Cycle." Infection and Immunity 67, no. 12 (1999): 6321–28. http://dx.doi.org/10.1128/iai.67.12.6321-6328.1999.

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ABSTRACT The levels of antigen-specific antibodies (Abs) and immunoglobulins in the cervical mucus of women vary with the menstrual cycle; the highest levels occur during menses, and the lowest occur during the periovulatory period. The rhesus macaque is a widely used animal model of female genital tract immunity. We sought to determine whether rhesus macaques have a cyclical pattern of changing cervicovaginal Ab and immunoglobulin levels that is similar to that of the human female. This study examined the relationship of the stages of the menstrual cycle to genital mucosal and systemic immuno

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El Mubarak, H. Sittana, Selma Yüksel, Geert van Amerongen, et al. "Infection of cynomolgus macaques (Macaca fascicularis) and rhesus macaques (Macaca mulatta) with different wild-type measles viruses." Journal of General Virology 88, no. 7 (2007): 2028–34. http://dx.doi.org/10.1099/vir.0.82804-0.

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Both rhesus and cynomolgus macaques have been used as animal models for measles vaccination and immunopathogenesis studies. A number of studies have suggested that experimental measles virus (MV) infection induces more-characteristic clinical features in rhesus than in cynomolgus monkeys. In the present study, both macaque species were infected with two different wild-type MV strains and clinical, virological and immunological parameters were compared. The viruses used were a genotype C2 virus isolated in The Netherlands in 1991 (MV-Bil) and a genotype B3 virus isolated from a severe measles c

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Borisevich, G. V., S. L. Kirillova, O. N. Sidorova, et al. "Analysis of Cellular Component Indicators of Immune Status of Rhesus Macaques." Problems of Particularly Dangerous Infections, no. 4 (February 7, 2021): 41–46. http://dx.doi.org/10.21055/0370-1069-2020-4-41-46.

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Objective. Selection of indicators of lymphocyte populations in rhesus macaques determined by flow cytometry to evaluate variations of cellular constituent of their immune status.Materials and methods. Blood of 11 healthy rhesus macaque males, 2,0–2,5 years old, weighing 2,5–3,0 kg, was used. Monkeys were examined simultaneously in each of 7 months of observation (since May till November). Immunophenotyping was conducted by FC500 cytofluorimeter using Affymetrix eBioscience monoclonal antibodies. The following cellular constituent indicators of immune status were differentiated: total T lympho

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Bissinger, David W., Luke A. Wittenburg, Laura M. Garzel, Diane E. Stockinger, and Gregory B. Timmel. "Pharmacokinetics of a Single Transdermal Dose of Mirtazapine in Rhesus Macaques (Macaca mulatta)." Comparative Medicine 73, no. 6 (2023): 432–38. http://dx.doi.org/10.30802/aalas-cm-23-000060.

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Decreased appetite is a common clinical problem in captive rhesus macaques (Macaca mulatta). Mirtazapine, a tetracyclic antidepressant originally developed for humans, has shown promise as a safe and effective promoter of weight gain and appetite in several veterinary species including rhesus and cynomolgus macaques. Although mirtazapine is available as oral formulations, transdermal delivery in macaques with reduced appetite would allow quick, painless, topical application. Here we describe the pharmacokinetics of a single application of a widely available veterinary transdermal mirtazapine f

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Souquière, Sandrine, Richard Onanga, Maria Makuwa, et al. "Simian immunodeficiency virus types 1 and 2 (SIV mnd 1 and 2) have different pathogenic potentials in rhesus macaques upon experimental cross-species transmission." Journal of General Virology 90, no. 2 (2009): 488–99. http://dx.doi.org/10.1099/vir.0.005181-0.

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The mandrill (Mandrillus sphinx) is naturally infected by two types of simian immunodeficiency virus (SIV): SIVmnd types 1 and 2. Both of these viruses cause long-term, non-progressive infections in their natural host despite high plasma viral loads. This study assessed the susceptibility of rhesus macaques to infection by these two types of SIVmnd and compared the virological and basic immunological characteristics of the resulting infections with those observed in natural infection in mandrills. Whilst both SIVmnd types induced similar levels of virus replication during acute infection in bo

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