Relevant bibliographies by topics / Machine perfusion

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Machine perfusion'

Author: Grafiati
Published: 4 June 2021
Last updated: 10 March 2023

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the lists of relevant articles, books, theses, conference reports, and other scholarly sources on the topic 'Machine perfusion.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Journal articles on the topic "Machine perfusion"

1

Hessheimer, Amelia J., Constantino Fondevila, and Juan C. García-Valdecasas. "Extracorporeal machine liver perfusion." Current Opinion in Organ Transplantation 17, no. 2 (April 2012): 143–47. http://dx.doi.org/10.1097/mot.0b013e328351082a.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

van Smaalen, Tim C., E. R. Pieter Hoogland, and L. W. Ernest van Heurn. "Machine perfusion viability testing." Current Opinion in Organ Transplantation 18, no. 2 (April 2013): 168–73. http://dx.doi.org/10.1097/mot.0b013e32835e2a1b.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Okamoto, Toshihiro, Hiromichi Niikawa, Kamal Ayyat, Ichiro Sakanoue, Sayf Said, and Kenneth R. McCurry. "Machine Perfusion of Lungs." Current Transplantation Reports 6, no. 4 (November 30, 2019): 251–64. http://dx.doi.org/10.1007/s40472-019-00258-x.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

van Leeuwen, Otto B., Isabel M. A. Brüggenwirth, Robert J. Porte, and Paulo N. Martins. "Development of a machine perfusion device for cold-to-warm machine perfusion." HPB 22, no. 9 (September 2020): 1368–69. http://dx.doi.org/10.1016/j.hpb.2020.05.014.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

Huang, Viola, Negin Karimian, Danielle Detelich, Siavash Raigani, Sharon Geerts, Irene Beijert, Fermin M. Fontan, et al. "Split-Liver Ex Situ Machine Perfusion: A Novel Technique for Studying Organ Preservation and Therapeutic Interventions." Journal of Clinical Medicine 9, no. 1 (January 18, 2020): 269. http://dx.doi.org/10.3390/jcm9010269.

Full text
Abstract:
Ex situ machine perfusion is a promising technology to help improve organ viability prior to transplantation. However, preclinical studies using discarded human livers to evaluate therapeutic interventions and optimize perfusion conditions are limited by significant graft heterogeneity. In order to improve the efficacy and reproducibility of future studies, a split-liver perfusion model was developed to allow simultaneous perfusion of left and right lobes, allowing one lobe to serve as a control for the other. Eleven discarded livers were surgically split, and both lobes perfused simultaneously on separate perfusion devices for 3 h at subnormothermic temperatures. Lobar perfusion parameters were also compared with whole livers undergoing perfusion. Similar to whole-liver perfusions, each lobe in the split-liver model exhibited a progressive decrease in arterial resistance and lactate levels throughout perfusion, which were not significantly different between right and left lobes. Split liver lobes also demonstrated comparable energy charge ratios. Ex situ split-liver perfusion is a novel experimental model that allows each graft to act as its own control. This model is particularly well suited for preclinical studies by avoiding the need for large numbers of enrolled livers necessary due to the heterogenous nature of discarded human liver research.
APA, Harvard, Vancouver, ISO, and other styles
6

Van Raemdonck, Dirk, Filip Rega, Steffen Rex, and Arne Neyrinck. "Machine perfusion of thoracic organs." Journal of Thoracic Disease 10, S8 (April 2018): S910—S923. http://dx.doi.org/10.21037/jtd.2018.02.85.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Macdonald, Peter S. "Machine Perfusion of Donor Hearts." Journal of Cardiac Failure 28 (2022): 9. http://dx.doi.org/10.1016/j.cardfail.2022.07.021.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

MacConmara, Malcolm, and Parsia A. Vagefi. "Machine Perfusion in Liver Transplantation." Advances in Surgery 55 (September 2021): 175–95. http://dx.doi.org/10.1016/j.yasu.2021.05.013.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Kataria, Ashish, Sandeep Magoon, Binni Makkar, and Aijaz Gundroo. "Machine perfusion in kidney transplantation." Current Opinion in Organ Transplantation 24, no. 4 (August 2019): 378–84. http://dx.doi.org/10.1097/mot.0000000000000675.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

O’Neill, Stephen, and Gabriel C. Oniscu. "Donor pretreatment and machine perfusion." Current Opinion in Organ Transplantation 25, no. 1 (February 2020): 59–65. http://dx.doi.org/10.1097/mot.0000000000000725.

Full text
APA, Harvard, Vancouver, ISO, and other styles
More sources

Dissertations / Theses on the topic "Machine perfusion"

1

Troutman, Mr Eric Christopher. "Hypothermic Machine Perfusion of Composite Tissues." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/81272.

Full text
Abstract:
Organ perfusion systems have successfully been applied to solid organ preservation and subsequent transplantation. However, their use in limb preservation for Vascularized Composite Tissue Allotransplantation (VCA) has yet to be thoroughly investigated. This thesis explores the potential for hypothermic machine perfusion in prolonging limb graft viability in a swine forelimb amputation model. The experiment was designed with the right and left forelimbs from the same pig randomly assigned to the treatment and control groups. Eighteen (18) limbs were procured from a local abattoir, vessels cannulated, and an initial flush of a modified phosphate buffered saline (PBS) solution was performed. Half of those limbs, assigned to the treatment group, were then preserved with continuous hypothermic machine perfusion for 12 hours. The perfusate was a PBS solution supplemented with 5% w/v dextrose. The remaining nine limbs, assigned to the control group, were placed into a plastic bag and kept at room temperature (ca. 20oC) for the entire duration of the experiment. Methylene blue was used to verify perfusion throughout limbs. Histopathological analysis revealed the presence of significantly greater deterioration of the perfused limbs compared to control. I concluded that PBS solution is not suitable for extended limb preservation. Inadequate perfusate volume and lack of solution replenishment resulted in metabolic waste build up, accelerating total organ damage. Continued research is needed in order to develop clinically relevant hypothermic machine perfusion devices capable of prolonged limb preservation.
Master of Science
APA, Harvard, Vancouver, ISO, and other styles
2

Hernandez, Leslie, and Leslie Hernandez. "Renal Perfusion Model: Outcome Predictions." Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/624104.

Full text
Abstract:
The Banner University Medical Center's (BUMC) renal transplant program relies on the LifePort Kidney Transporter to optimize marginal kidney organs via hypothermic machine perfusion (HMP) prior to transplantation. Hemodynamic parameters produced by the device followed over the duration of support, combined with clinical experience, guide decisions in determining the acceptability of a donor kidney for implantation. Thus far, statistical evidence supporting ideal parameters remain undefined. The purpose of this study is to create a logistic model that will ascertain the post-implant sustainability of LifePort® supported kidneys and predict clinical outcomes. My hypothesis is that the statistical models constructed based on retrospective LifePort® parameters and clinical outcome data will successfully predict donor organ vascular health for transplantation and the optimal support duration. A successful model will contribute to increased efficiencies in the kidney transplant process as well as improved patient outcomes. An overview of the institution’s success was weighed using a survival analysis, with delayed graft function (DGF) as the endpoint. A logistic regression model and forecast model were built to predict the outcome for rejecting or accepting the organ for transplant, as well as to predict the hemodynamic parameters hours after the start of infusion. Results concluded a flow greater than 80 mL/min had a 90% probability of transplantation. The forecast model was capable of predicting flow for up to five hours. The calculated flow was in a 10 mL/min range of the actual flow, when up to one hour parameters were entered into the model. The study concluded practicality in the clinical setting, in kidney transplantation.
APA, Harvard, Vancouver, ISO, and other styles
3

Hamaoui, Karim. "Machine perfusion for assessing and optimizing kidney and pancreas allografts." Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/55177.

Full text
Abstract:
Introduction: The predominate issue in transplantation today is the inadequate supply of suitable organs for an increasing number of patients on the transplant waiting lists. In efforts to address this demand there has been an increasing use of expanded-criteria and donation-after-cardiac death donor kidneys and pancreases, however these organs are at higher risk for reperfusion injury. Advances in organ preservation thus need to focus on techniques to assess and optimise organ viability prior to transplantation. Methods: This research focuses on organ viability assessment during preservation using rapid sampling micro-dialysis (rsMD); preconditioning organs with novel endothelial localising anticoagulants to prevent micro-vascular thrombotic complications; development of both novel hypothermic machine perfusion (HMP) solutions to minimise reperfusion injury, and HMP strategies that offer superior preservation of organ integrity compared to static cold storage (SCS). Using HMP and normothermic-reperfusion models of porcine and human kidney and pancreatic grafts, this project has investigated strategies addressing these themes. Results: rsMD can successfully provide detailed real-time information on tissue and organ viability during both SCS and HMP. Pre-conditioning grafts with novel localising anticoagulant proteins has been successful in ameliorating disturbances in macro and micro-vascular perfusion and graft microcvascular thrombosis, processes which play key roles in reperfusion injury and organ dysfunction. Separately the application of a novel adenosine/lidocaine based preservation solution in renal HMP preservation can potentially ameliorate reperfusion injury seen using conventional solutions. Post-ischaemic HMP reconditioning has been investigated in the context of recovering organs with an extreme period of SCS which may be a potential option to expand donor organ pools. Finally models of pancreatic HMP have been successfully established, opening the potential for organ viability assessment and optimization. Conclusion: This research has been successful in its overall objective to develop novel translational strategies that have high potential for clinical implementation. In doing so the goal would be to enable an expansion of the pool of acceptable donor organs by improving the methods used to determine and optimise their viability, specifically more effective preservation techniques and by addressing specific post-operative complications through graft preconditioning.
APA, Harvard, Vancouver, ISO, and other styles
4

Guy, Alison Jane. "Machine perfusion in kidney transplantation : clinical application & metabolomic analysis." Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/6395/.

Full text
Abstract:
Kidney Transplantation is the gold standard treatment for patients with end-stage renal failure. Most kidneys used for transplantation are from deceased donors and ensuring successful outcomes depends on many factors. One of these is organ storage. Hypothermic Machine Perfusion (HMP) of deceased donor organs has been shown to have several benefits. However, it has not been widely adopted and the underlying mechanism is poorly understood. The first section of this thesis examines the introduction of HMP into clinical practice. HMP outcomes were similar to those of standard storage techniques but with the additional benefit of increasing safe storage times. This was likely due to inherent benefits of the machine itself, improved recipient preparation and better peri-operative conditions. The second part of this study analysed HMP perfusate using metabolomics (Nuclear Magnetic Resonance) to identify potential predictors of graft outcome. Differences were identified in the metabolic profiles of perfusate from kidneys with immediate and delayed graft function. These may have a future role in viability assessment. Improved understanding of metabolism during storage may help target optimization strategies for deceased donor organs. The final part of this study describes the development of a porcine model of transplantation to test future hypotheses.
APA, Harvard, Vancouver, ISO, and other styles
5

Webster, Kelly Eileen. "Quantifying Renal Swelling during Machine Perfusion using Digital Image Correlation." Thesis, Virginia Tech, 2017. http://hdl.handle.net/10919/78244.

Full text
Abstract:
While machine perfusion of explanted kidneys is theoretically superior to standard cold storage, it may damage potential transplants unless machine-associated swelling is controlled. This thesis presents the effects of perfusate tonicity on renal swelling during hypothermic machine perfusion. Phosphate buffered solution (PBS) and PBS supplemented with 5% w/v mannitol were used as isotonic (289 mOsm/kg) and hypertonic (568 mOsm/kg) perfusates, respectively. Porcine kidney pairs were procured then flushed and machine perfused; the right and left kidneys were assigned opposite perfusates. An experimental methodology was developed to image porcine kidneys undergoing hypothermic machine perfusion (5 deg C) for 15 minutes followed by 120 minutes without perfusion to quantify surface displacement (renal swelling) with digital image correlation (DIC). Surface displacement and size (thickness) were compared between the right and left kidneys of each pair. In addition, discharged renal fluids (i.e., filtrate and venous outflow) and biopsies were collected. On average, kidneys perfused with the mannitol solution were smaller in size than the kidneys perfused with PBS (p < 0.05) at the start and end of each experiment; however, there was no significant difference between the renal sizes at the end of the 15 minute perfusion interval (p > 0.05). Thus, hypertonic and isotonic perfusates yielded different renal swelling outcomes (i.e., physical size and surface displacement), which suggests that perfusate tonicity influences renal swelling. These experiments are the first time ex vivo renal surface displacement measurements have been collected during machine perfusion.
Master of Science
APA, Harvard, Vancouver, ISO, and other styles
6

Nakajima, Daisuke. "Reconditioning Lungs Donated After Cardiac Death Using Short-Term Hypothermic Machine Perfusion." Kyoto University, 2016. http://hdl.handle.net/2433/216177.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Hameed, Ahmer Mohammad. "Modifying Donor Organ Retrieval and Preservation to Enhance Transplant Outcomes." Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/20363.

Full text
Abstract:
The last 1-2 decades have seen remarkable advances in organ procurement and preservation practices, especially with renewed enthusiasm for machine perfusion (MP) technology. However, cold static storage (CS) remains the most popular world-wide approach for the preservation of organs such as the kidneys, liver, and pancreas, largely due to its simplicity. It is clear that CS techniques have limited potential for further improvement, and will likely be supplanted and/or supplemented with MP technologies over the coming years due to the reparative, resuscitative, and assessment capabilities afforded by MP. This is especially important as we increase our utilisation of marginal and/or donation after circulatory death (DCD) organs to meet the ever-increasing demand requirements for transplantation. This dissertation explores selected aspects of abdominal organ procurement and preservation as targets for improvement and/or modification with the aim to enhance recipient transplantation outcomes. The kidney is used as a model organ for the development and exploration of MP as a means to ameliorate transplant organ ischaemia-reperfusion injury (IRI), including through the targeted delivery of anti-IRI drugs. In contrast, the optimization of CS protocols, including identification of ideal perfusion fluids and in situ perfusion routes, forms the basis for liver and pancreas transplantation work in this thesis. Such investigations are necessary to promote uniformity of practice between centres, and allow appropriate comparisons between MP and CS. The kidney MP work was guided by a systematic review and meta-analysis comparing MP and CS in the clinical and pre-clinical setting. Although hypothermic MP (HMP) was shown to enhance short-term graft outcomes, results were equivocal with respect to graft survival, especially in the DCD setting. Preliminary evidence indicated the potential superiority of normothermic MP (NMP) above HMP or CS, which may be further enhanced by using NMP as a conduit for directed drug delivery to the kidney to ameliorate IRI. We therefore developed and optimized a local NMP set-up using a series of porcine kidneys, which was then utilized to deliver the anti-IRI agent CD47-blocking antibody (αCD47Ab) in a porcine DCD model. The significant potential of this agent was initially confirmed by testing in a murine model of severe warm IRI, including its comparative efficacy to two other promising IRI agents, soluble complement receptor 1 (sCR1), and recombinant thrombomodulin, and also sCR1 in combination with αCD47Ab. αCD47Ab was successfully delivered to porcine DCD kidneys using NMP, with subsequent downstream positive impacts upon renal perfusion, and some functional and IRI-related parameters. The clinical utilisation of renal NMP has so far been limited to the UK, and this modality has not been tested in human kidneys in Australasia. Furthermore, the mechanistic basis of brief renal NMP is not entirely clear. Therefore, and as a prelude to a phase I clinical trial, NMP was tested in discarded deceased donor human kidneys. Fifteen kidneys were obtained from 10 donors, and successfully underwent NMP. NMP was especially effective for assessing and improving DCD kidneys discarded for poor macroscopic perfusion at retrieval. Flow cytometry analyses showed evidence of a massive passenger leukocyte efflux during NMP. In paired kidney analyses, one hour of NMP was shown to be superior to CS alone after simulated transplantation using ex vivo whole allogeneic blood reperfusion, in terms of renal perfusion and functional parameters. Whole transcriptome RNA sequencing revealed NMP-mediated induction of protective stress and inflammatory-related pathways, in addition to a reduction in cell death pathways. Accordingly, immunofluorescence techniques confirmed a reduction in cell death and IRI in NMP kidneys compared to their CS counterparts. CS and procurement techniques formed the basis of liver and pancreas transplantation-related studies conducted for this thesis. Firstly, we showed that blood transfusion requirements can be significantly reduced in recipients if the pancreas is retrieved using ultrasonic shears (Harmonic Scalpel), implying a reduction in procedural risk and recipient sensitization. Two systematic reviews and meta-analyses were then conducted to ascertain optimal in situ perfusion/preservation fluids, and perfusion routes, during procurement of pancreatic and hepatic allografts. There was a lack of overwhelming evidence favouring any specific preservation fluid, although University of Wisconsin solution will likely remain the solution of choice, especially for the pancreas. Furthermore, in standard criteria donors, aortic-only perfusion was found to produce equivalent liver transplant outcomes in comparison to dual (aorto-portal perfusion). However, existing studies included small patient numbers and short periods of follow-up. We therefore compared aortic and dual perfusion during liver retrieval using the Australia and New Zealand Liver Transplant Registry, which provided a much larger patient cohort with prolonged follow-up. This study confirmed the equivalence of aortic-only and dual perfusion in standard criteria liver donors, however there was also evidence indicating the superiority of dual perfusion in a subset of suboptimal/higher risk donors. Overall, this thesis expounds upon the putative benefits of NMP in kidney transplantation, including by directed drug delivery targeting the IRI cascade, and also enhances our understanding of optimal perfusion routes and preservation fluids for the liver and pancreas. The ultimate aim is to facilitate expansion of the donor pool whilst simultaneously enhancing recipient transplantation outcomes through the evidence-based implementation of technologies and techniques in a unified and coordinated manner.
APA, Harvard, Vancouver, ISO, and other styles
8

Codas, Duarte Ricardo. "Ischémie-reperfusion : impact de la perfusion rénale sur la fonction des greffons." Thesis, Poitiers, 2013. http://www.theses.fr/2013POIT1404/document.

Full text
Abstract:
La pénurie d'organes a amené les équipes de transplantation à élargir l'acceptation des greffons à des organes provenant de donneurs marginaux.Le recours aux greffons marginaux impose de réduire les lésions induites durant l'IR, et doit conduire à une prise en charge optimisée de façon à limiter le risque de PNF et de RRF.C'est face à cette situation, que la question de la perfusion d'organe et de l'utilisation des machines de perfusion s'est posée et a justifié la réalisation de ce travail.Un modèle d'autotransplantation chez le porc a été choisi car il permet d'évaluer les effets de l'IR sur le rein.Les reins ont subi une ischémie contrôlée. La conservation des reins a été randomisée soit en incubation statique dans IGL-1 ou Belzer MPS soit sur machine de perfusion.Nous avons utilisé comme paramètre d'étude : la survie des animaux, différents dosages biologiques, une analyse histologique et une évaluation immunologique par RTqPCR des certains gènes impliqués dans le mécanisme lésionnel d'IR.Nos résultats montrent au total :-Que la machine de perfusion RM3 diminue le risque de RRF et PNF post greffe.-La supériorité de l'IGL-1 sur le Belzer MPS ; il existe un effet propre de la solution IGL-1 pour moduler les mécanismes inflammatoires et immunologiques liés aux lésions d'IR.-Que la reprise de fonction et la PNF dépendent du liquide utilisé et qu'il existe un effet d'addition entre l'IGL-1 et la machine de perfusion
Organ shortage has led transplant teams to re-evaluate their acceptance criteria and to increase their use of marginal donor organs (ECD and DDAC). For this reason, it is necessary to reduce the lesions due to IR. By optimizing organ conservation, the risk of PNF and RRF can be limited, and organ survival increased. The question of organ perfusion and the use of perfusion machines arose in this context, leading to the work we present here.We chose to evaluate the effects of IR on a porcine auto-graft model, that being the gold standard for the study of IR lesions.The kidneys were subject to hot ischemia for 60 minutes, and then to cold ischemia for 22 hours, during which they were randomly conserved either through static incubation in IGL-1 or Belzer MPS or on a perfusion machine.We studied the animal survival rate, various bioassays, histological analysis and immune reactions though RTqPCR of certain genes involved in IR lesion mechanisms.Our results show:-That the RM3 perfusion machine decreases the RRF and PNF post-graft risk and thus the perfusion machine conservation is better than static conservation.-IGL-1 superiority over Belzer MPS; IGL-1 solution independently modulates inflammatory and immunological mechanisms linked to IR lesions.-That function recovery and PNF depend on the liquid used where there is an additive effect between the use of IGL-1 and the use of a perfusion machine
APA, Harvard, Vancouver, ISO, and other styles
9

Jay, Nath. "The clinical benefits and metabolic mechanisms of ex vivo machine perfusion of kidneys prior to transplantation." Thesis, University of Birmingham, 2017. http://etheses.bham.ac.uk//id/eprint/7647/.

Full text
Abstract:
Hypothermic machine perfusion (HMP) is well established in the practice of renal transplantation and is associated with improved short and long-term outcomes for selected organs. Despite the advantages of this therapy during the period prior to transplantation, the mechanisms by which these benefits occur are not entirely clear and are likely to include factors additional to improved flow dynamics. In the first part of this thesis, using both a local and national transplant dataset, I aim to establish the benefits (if any) and rationale for HMP relevant to current UK practice for both deceased and live donor kidneys. In the second part of this thesis the mechanisms by which HMP exert benefit are further interrogated, with a particular focus on metabolism. Nuclear magnetic resonance (NMR) spectroscopy is the principal modality through which this is investigated and in addition to established 1D 1H NMR protocols, glucose tracer studies using 2D 13C NMR are described. Whole organ ex vivo perfusion is studied in this work using human kidneys (both transplanted and non-transplanted) and porcine organs, with the porcine model validated for metabolic studies. In the final section, methods to modify metabolism during HMP are attempted, with the effects of supplemental oxygenation described.
APA, Harvard, Vancouver, ISO, and other styles
10

Hoffmann, Nico. "Dynamic Thermal Imaging for Intraoperative Monitoring of Neuronal Activity and Cortical Perfusion." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230847.

Full text
Abstract:
Neurosurgery is a demanding medical discipline that requires a complex interplay of several neuroimaging techniques. This allows structural as well as functional information to be recovered and then visualized to the surgeon. In the case of tumor resections this approach allows more fine-grained differentiation of healthy and pathological tissue which positively influences the postoperative outcome as well as the patient's quality of life. In this work, we will discuss several approaches to establish thermal imaging as a novel neuroimaging technique to primarily visualize neural activity and perfusion state in case of ischaemic stroke. Both applications require novel methods for data-preprocessing, visualization, pattern recognition as well as regression analysis of intraoperative thermal imaging. Online multimodal integration of preoperative and intraoperative data is accomplished by a 2D-3D image registration and image fusion framework with an average accuracy of 2.46 mm. In navigated surgeries, the proposed framework generally provides all necessary tools to project intraoperative 2D imaging data onto preoperative 3D volumetric datasets like 3D MR or CT imaging. Additionally, a fast machine learning framework for the recognition of cortical NaCl rinsings will be discussed throughout this thesis. Hereby, the standardized quantification of tissue perfusion by means of an approximated heating model can be achieved. Classifying the parameters of these models yields a map of connected areas, for which we have shown that these areas correlate with the demarcation caused by an ischaemic stroke segmented in postoperative CT datasets. Finally, a semiparametric regression model has been developed for intraoperative neural activity monitoring of the somatosensory cortex by somatosensory evoked potentials. These results were correlated with neural activity of optical imaging. We found that thermal imaging yields comparable results, yet doesn't share the limitations of optical imaging. In this thesis we would like to emphasize that thermal imaging depicts a novel and valid tool for both intraoperative functional and structural neuroimaging.
APA, Harvard, Vancouver, ISO, and other styles
More sources

Books on the topic "Machine perfusion"

1

Jeremy, Wight, National Co-ordinating Centre for HTA (Great Britain), and Health Technology Assessment Programme, eds. The Clinical and cost-effectiveness of pulsatile machine perfusion versus cold storage of kidneys for transplantation retrieved from heart-beating and non-heart-beating donors. Southampton: NCCHTA, 2003.

Find full text
APA, Harvard, Vancouver, ISO, and other styles
2

Raju, Raghavan, and Irshad H. Chaudry. The host response to hypoxia in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0305.

Full text
Abstract:
The hypoxic response of the host is complex. While the oxygen-sensing intracellular machinery attempts to restore cellular homeostasis by augmenting respiration and blood flow, events such as severe haemorrhage lead to whole body hypoxia and decreased mitochondrial function. Immunological perturbations following severe haemorrhage may result in multiple organ dysfunction and sepsis, while impaired perfusion may lead to microvascular injury and local hypoxia. Trauma-haemorrhage or hypoxic exposure in animals causes a systemic inflammatory response, decreased antigen presentation by peritoneal macrophages, hypoxaemia and initiation of endoplasmic reticulum stress. In response, the protein level of the oxygen-sensing transcription factor, hypoxia inducible factor (HIF)-1 increases; this leads to the regulation of expression of a number of genes resulting in decreased mitochondrial ATP production, but enhanced glycolytic processes, thus shifting the energy balance. In addition, sustained tissue hypoxia leads to increased free radical production and cellular apoptosis. Though the initial host response to hypoxia may be protective, sustained hypoxia becomes detrimental to the tissues and the organism as a whole.
APA, Harvard, Vancouver, ISO, and other styles

Book chapters on the topic "Machine perfusion"

1

Hessheimer, Amelia J., Gabriel Cárdenas, and Constantino Fondevila. "Machine Perfusion." In Textbook of Liver Transplantation, 669–82. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-030-82930-8_40.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Kumar, G. V. Prem, P. Balachandran, and K. Anusha. "Normothermic Machine Perfusion." In Peri-operative Anesthetic Management in Liver Transplantation, 361–72. Singapore: Springer Nature Singapore, 2023. http://dx.doi.org/10.1007/978-981-19-6045-1_28.

Full text
APA, Harvard, Vancouver, ISO, and other styles
3

Blum, Matthew F., Qiang Liu, Basem Soliman, Toshihiro Okamoto, Bahar Bassiri-Gharb, Teresa Diago Uso, Laura D. Buccini, and Cristiano Quintini. "Machine Perfusion of Organs." In Technological Advances in Organ Transplantation, 21–62. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-62142-5_2.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Pezzati, Daniele, Qiang Liu, and Cristiano Quintini. "Ex Vivo Normothermic Machine Perfusion." In Donation after Circulatory Death (DCD) Liver Transplantation, 217–35. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-46470-7_15.

Full text
APA, Harvard, Vancouver, ISO, and other styles
5

De Carlis, Riccardo, Vincenzo Buscemi, Andrea Lauterio, Stefano Di Sandro, and Luciano De Carlis. "Machine Perfusion in Liver Transplantation." In Liver Transplantation and Hepatobiliary Surgery, 41–52. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-19762-9_5.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Matsuno, Naoto. "Machine Perfusion Preservation for Kidney Transplantation." In Marginal Donors, 163–75. Tokyo: Springer Japan, 2014. http://dx.doi.org/10.1007/978-4-431-54484-5_15.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Werner, Maureen J. M., Vincent E. de Meijer, and Robert J. Porte. "Machine Perfusion of Human Donor Livers." In Transplantation Surgery, 339–54. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-55244-2_21.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Feghhi, Ebrahim, Yinsheng Zhou, John Tran, David S. Liebeskind, and Fabien Scalzo. "Angio-AI: Cerebral Perfusion Angiography with Machine Learning." In Advances in Visual Computing, 357–67. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-33720-9_27.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Freitas, D., H. A. Almeida, and P. J. Bártolo. "Permeability Evaluation of Flow Behaviors Within Perfusion Bioreactors." In New Trends in Mechanism and Machine Science, 761–68. Cham: Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-09411-3_80.

Full text
APA, Harvard, Vancouver, ISO, and other styles
10

Cheng, Kellen, Kunakorn Atchaneeyasakul, Zeid Barakat, David S. Liebeskind, and Fabien Scalzo. "CT Perfusion Imaging of the Brain with Machine Learning." In Advances in Visual Computing, 41–52. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-90436-4_4.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Conference papers on the topic "Machine perfusion"

1

Zhao Xinzhong and Wu Di. "Simulation on hot drug perfusion machine system." In 2010 International Conference on Computer Application and System Modeling (ICCASM 2010). IEEE, 2010. http://dx.doi.org/10.1109/iccasm.2010.5622235.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Purohit, Saurin P., Joshua Nelson, Jian Zhang, Mark G. Clemens, and Charles Y. Lee. "Flow Dynamics During Machine Perfusion Preservation of Livers." In ASME 2001 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2001. http://dx.doi.org/10.1115/imece2001/htd-24423.

Full text
Abstract:
Abstract Hypothermic machine perfusion preservation (MPP) has the potential to relieve the current donor shortage problem by providing superior preserved tissue and viable non-heart-beating donor tissue. For the liver, MPP has not improved preservation. Currently, the major cause of damage associated with MPP of livers is unknown. An intravital microscopy study was conducted to investigate the state of sinusoidal perfusion during 24-hour MPP. Fluorescein isothiocynate (FITC)-labeled albumin was utilized to mark the microvascular space while FITC-labeled red blood cells were used to determine the fluid velocity. The results showed that there was an increase in vascular resistance (&gt; 275%) when the liver was perfused with a UW solution for 24 hours at 5°C and with a flow rate of 5 ml/min. This vascular resistance further increased (&gt; 425%) during rewarming (for 1 hour, at 37°C and 15 ml/min). The mean flow velocities increased during initial MPP from 236 ±16 μm/s (mean ± standard error) to 434 ± 20 μm/s and the mean shear stress values increased from 5.3 ± 0.8 dynes/cm2 to 6.5 ± 0.8 dynes/cm2, after 24 hours of MPP the mean flow velocity values and shear stress values decreased (223 ± 13 μm/s and 3.3 ± 0.8 dynes/cm2) respectively. The reason for this was detected by the FITC-labeled albumin, in the tissue. It was evident that these areas (after 24 hours of MPP) also displayed increased blockage. It also appeared from the micrographs and the histology study that the blockage occurred as a result of endothelial cells rounding after 24 hours of MPP. The cells remained rounded even after rewarming the tissue. This could be a mechanism of damage to the liver during 24-hour of MPP.
APA, Harvard, Vancouver, ISO, and other styles
3

Turco, Simona, Christina Keravnou, Ruud J. G. van Sloun, Hessel Wijkstra, Mike Averkiou, and Massimo Mischi. "Effects of perfusion and vascular architecture on contrast dispersion: Validation in ex-vivo porcine liver under machine perfusion." In 2016 IEEE International Ultrasonics Symposium (IUS). IEEE, 2016. http://dx.doi.org/10.1109/ultsym.2016.7728488.

Full text
APA, Harvard, Vancouver, ISO, and other styles
4

Jain, Shailendra, Saurin Purohit, Jian Zhang, Mark G. Clemens, and Charles Y. Lee. "Visualization of Endothelial Cell Structure During Machine Perfusion Preservation of Livers." In ASME 2002 International Mechanical Engineering Congress and Exposition. ASMEDC, 2002. http://dx.doi.org/10.1115/imece2002-33072.

Full text
Abstract:
The development of machine perfusion preservation (MPP) of kidney has led to significant improvements and greater success rates in kidney transplantation by providing superior preserved tissue and viable non-heart-beating donor tissue. However, machine perfusion of livers has not been successful in improving preservation. Currently, the major cause of damage associated with MPP of livers remains unclear. Previous studies showed increased vascular resistance and blockages during and after 24hrs MPP but no direct evidence existed. Utilizing a novel two colors fluorophores labeling, an intravital microscopic study was conducted to obtain real time images and confocal microscopy to get detailed images in order to correlate fluorescent-tagged endothelial cells (ECs) with red cell stasis. Fluorescein isothiocynate (FITC) was used to label red blood cells (RBCs) and DiI acetylated low-density lipoprotein (DiI acLDL) was used to mark ECs. Structure of ECs was recorded and assessed during 24hrs MPP with University of Wisconsin (UW) solution at 4°C with a flow rate of 4ml/min. Images recorded from intravital microscopy and confocal microscopy show ECs rounding over a period of 24 hrs and subsequent red blood cells stasis after 24hrs MPP and during rewarming.
APA, Harvard, Vancouver, ISO, and other styles
5

Dhinakaran, M., P. Praveen Kumar, and S. Abraham Lincon. "Modeling and controller design of perfusion system for heart lung machine." In 2014 2nd International Conference on Current Trends in Engineering and Technology (ICCTET). IEEE, 2014. http://dx.doi.org/10.1109/icctet.2014.6966266.

Full text
APA, Harvard, Vancouver, ISO, and other styles
6

Chen, Melinda, Qian Li, Negin Karimian, Heidi Yeh, Yu Duan, Fermin Fontan, Mohamed M. Aburawi, Brian W. Anthony, Korkut Uygun, and Anthony E. Samir. "Contrast-Enhanced Ultrasound to Quantifyc Perfusion in a Machine-Perfused Pig Liver." In 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2018. http://dx.doi.org/10.1109/embc.2018.8512893.

Full text
APA, Harvard, Vancouver, ISO, and other styles
7

Chusri, Yanee, Goragoch Gesprasert, Thananya Khienwad, and Phornphop Naiyanate. "The effect of hypothermic machine perfusion and cold storage for kidney preservation." In 2017 10th Biomedical Engineering International Conference (BMEiCON). IEEE, 2017. http://dx.doi.org/10.1109/bmeicon.2017.8229128.

Full text
APA, Harvard, Vancouver, ISO, and other styles
8

Nuster, Robert, Bettina Leber, Guenther Paltauf, and Philipp Stiegler. "Multimodal photoacoustic and ultrasound imaging of organs during ex-vivo machine perfusion." In Photons Plus Ultrasound: Imaging and Sensing 2023, edited by Alexander A. Oraevsky and Lihong V. Wang. SPIE, 2023. http://dx.doi.org/10.1117/12.2655452.

Full text
APA, Harvard, Vancouver, ISO, and other styles
9

Debbaut, C., D. Monbaliu, C. Casteleyn, P. Cornillie, D. Van Loo, B. Masschaele, J. Pirenne, P. Simoens, L. Van Hoorebeke, and P. Segers. "From Human Liver Vascular Corrosion Cast to Electrical Analog Model of the Hepatic Blood Flow." In ASME 2010 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2010. http://dx.doi.org/10.1115/sbc2010-19213.

Full text
Abstract:
Machine perfusion (MP) is experiencing a revival in organ preservation due to the limitations of static cold storage and the need for better preservation methods for expanded criteria donors. Liver MP prototypes, however, face problems such as potential damage to sinusoidal endothelial cells, and heterogeneous perfusion related to the complex hepatic microcirculation.
APA, Harvard, Vancouver, ISO, and other styles
10

Wang, Ze, Anna R. Childress, and John A. Detre. "Boost up the detection sensitivity of ASL perfusion fMRI through support vector machine." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.260382.

Full text
APA, Harvard, Vancouver, ISO, and other styles

Reports on the topic "Machine perfusion"

1

Yang, Xiangfeng, Yunlong Li, Yuanzhe Li, Qing Guo, and Xiangyu zhong. Effectiveness of Machine Perfusion Used in Liver Transplantation: A Meta-analysis of Randomized Controlled Trials (RCTs). INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, November 2022. http://dx.doi.org/10.37766/inplasy2022.11.0018.

Full text
APA, Harvard, Vancouver, ISO, and other styles
2

Si, Tengfei, Zhenlin Huang, Salma Mujib, and Yun Ma. Normothermic machine perfusion versus static cold storage for liver graft preservation: a systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, June 2020. http://dx.doi.org/10.37766/inplasy2020.6.0038.

Full text
APA, Harvard, Vancouver, ISO, and other styles
You might also be interested in the extended bibliographies on the topic 'Machine perfusion' for particular source types:
Journal articles Dissertations / Theses
We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!

To the bibliography