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Journal articles on the topic 'Machine perfusion'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

Hessheimer, Amelia J., Constantino Fondevila, and Juan C. García-Valdecasas. "Extracorporeal machine liver perfusion." Current Opinion in Organ Transplantation 17, no. 2 (April 2012): 143–47. http://dx.doi.org/10.1097/mot.0b013e328351082a.

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van Smaalen, Tim C., E. R. Pieter Hoogland, and L. W. Ernest van Heurn. "Machine perfusion viability testing." Current Opinion in Organ Transplantation 18, no. 2 (April 2013): 168–73. http://dx.doi.org/10.1097/mot.0b013e32835e2a1b.

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3

Okamoto, Toshihiro, Hiromichi Niikawa, Kamal Ayyat, Ichiro Sakanoue, Sayf Said, and Kenneth R. McCurry. "Machine Perfusion of Lungs." Current Transplantation Reports 6, no. 4 (November 30, 2019): 251–64. http://dx.doi.org/10.1007/s40472-019-00258-x.

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4

van Leeuwen, Otto B., Isabel M. A. Brüggenwirth, Robert J. Porte, and Paulo N. Martins. "Development of a machine perfusion device for cold-to-warm machine perfusion." HPB 22, no. 9 (September 2020): 1368–69. http://dx.doi.org/10.1016/j.hpb.2020.05.014.

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5

Huang, Viola, Negin Karimian, Danielle Detelich, Siavash Raigani, Sharon Geerts, Irene Beijert, Fermin M. Fontan, et al. "Split-Liver Ex Situ Machine Perfusion: A Novel Technique for Studying Organ Preservation and Therapeutic Interventions." Journal of Clinical Medicine 9, no. 1 (January 18, 2020): 269. http://dx.doi.org/10.3390/jcm9010269.

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Ex situ machine perfusion is a promising technology to help improve organ viability prior to transplantation. However, preclinical studies using discarded human livers to evaluate therapeutic interventions and optimize perfusion conditions are limited by significant graft heterogeneity. In order to improve the efficacy and reproducibility of future studies, a split-liver perfusion model was developed to allow simultaneous perfusion of left and right lobes, allowing one lobe to serve as a control for the other. Eleven discarded livers were surgically split, and both lobes perfused simultaneously on separate perfusion devices for 3 h at subnormothermic temperatures. Lobar perfusion parameters were also compared with whole livers undergoing perfusion. Similar to whole-liver perfusions, each lobe in the split-liver model exhibited a progressive decrease in arterial resistance and lactate levels throughout perfusion, which were not significantly different between right and left lobes. Split liver lobes also demonstrated comparable energy charge ratios. Ex situ split-liver perfusion is a novel experimental model that allows each graft to act as its own control. This model is particularly well suited for preclinical studies by avoiding the need for large numbers of enrolled livers necessary due to the heterogenous nature of discarded human liver research.

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Van Raemdonck, Dirk, Filip Rega, Steffen Rex, and Arne Neyrinck. "Machine perfusion of thoracic organs." Journal of Thoracic Disease 10, S8 (April 2018): S910—S923. http://dx.doi.org/10.21037/jtd.2018.02.85.

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Macdonald, Peter S. "Machine Perfusion of Donor Hearts." Journal of Cardiac Failure 28 (2022): 9. http://dx.doi.org/10.1016/j.cardfail.2022.07.021.

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8

MacConmara, Malcolm, and Parsia A. Vagefi. "Machine Perfusion in Liver Transplantation." Advances in Surgery 55 (September 2021): 175–95. http://dx.doi.org/10.1016/j.yasu.2021.05.013.

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Kataria, Ashish, Sandeep Magoon, Binni Makkar, and Aijaz Gundroo. "Machine perfusion in kidney transplantation." Current Opinion in Organ Transplantation 24, no. 4 (August 2019): 378–84. http://dx.doi.org/10.1097/mot.0000000000000675.

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O’Neill, Stephen, and Gabriel C. Oniscu. "Donor pretreatment and machine perfusion." Current Opinion in Organ Transplantation 25, no. 1 (February 2020): 59–65. http://dx.doi.org/10.1097/mot.0000000000000725.

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Van Raemdonck, Dirk, Arne Neyrinck, Filip Rega, Timothy Devos, and Jacques Pirenne. "Machine perfusion in organ transplantation." Current Opinion in Organ Transplantation 18, no. 1 (February 2013): 24–33. http://dx.doi.org/10.1097/mot.0b013e32835c494f.

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12

Thompson, Emily R., Chloe Connelly, Simi Ali, Neil S. Sheerin, and Colin H. Wilson. "Cell therapy during machine perfusion." Transplant International 34, no. 1 (November 24, 2020): 49–58. http://dx.doi.org/10.1111/tri.13780.

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13

Jespersen, Bente. "Adding Medicine During Machine Perfusion." Transplantation 100, no. 12 (December 2016): 2524–25. http://dx.doi.org/10.1097/tp.0000000000001474.

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Peltz, Matthias, Michael L. Cobert, David H. Rosenbaum, LaShondra M. West, and Michael E. Jessen. "Myocardial perfusion characteristics during machine perfusion for heart transplantation." Surgery 144, no. 2 (August 2008): 225–32. http://dx.doi.org/10.1016/j.surg.2008.05.002.

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15

Goumard, Claire, Eric Savier, Jérôme Danion, Jérôme Pelissié, Cécile Legallais, and Olivier Scatton. "Response to: development of a machine perfusion device for cold-to-warm machine perfusion." HPB 22, no. 9 (September 2020): 1370–71. http://dx.doi.org/10.1016/j.hpb.2020.06.007.

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16

Ries, WP, Y. Marie, K. Patel, C. Turnbull, TB Smith, NSM Jamil, H. Caldwell, et al. "A simple ex vivo model of human renal allograft preservation using the gonadal vein." Annals of The Royal College of Surgeons of England 101, no. 8 (November 2019): 609–16. http://dx.doi.org/10.1308/rcsann.2019.0107.

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Introduction Hypothermic machine perfusion, an organ preservation modality, involves flow of chilled preservation fluid through an allograft’s vasculature. This study describes a simple, reproducible, human model that allows for interrogation of flow effects during ex vivo organ perfusion. Materials and methods Gonadal veins from deceased human renal allografts were subjected to either static cold storage or hypothermic machine perfusion for up to 24 hours. Caspase-3, Krüppel-like factor 2 expression and electron microscopic analysis were compared between ‘flow’ and ‘no-flow’ conditions, with living donor gonadal vein sections serving as negative controls. Results The increase in caspase-3 expression was less pronounced for hypothermic machine-perfused veins compared with static cold storage (median-fold increase 1.2 vs 2.3; P < 0.05). Transmission electron microscopy provided ultrastructural corroboration of endothelial cell apoptosis in static cold storage conditions. For static cold storage preserved veins, Krüppel-like factor 2 expression diminished in a time-dependent manner between baseline and 12 hours (P < 0.05) but was abrogated and reversed by hypothermic machine perfusion (P < 0.05). Conclusions Our methodology is a simple, reproducible and successful model of ex vivo perfusion in the context of human organ preservation. To demonstrate the model’s utility, we establish that two widely used markers of endothelial health (caspase-3 and Krüppel-like factor 2) differ between the flow and no-flow conditions of the two predominant kidney preservation modalities. These findings suggest that ex vivo perfusion may mediate the induction of a biochemically favourable endothelial niche which may contribute tohypothermic machine perfusion’s association with improved renal transplantation outcomes.

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Liew, Belle, David Nasralla, Satheesh Iype, Joerg-Matthias Pollok, Brian Davidson, and Dimitri A. Raptis. "Liver transplant outcomes after ex vivo machine perfusion: a meta-analysis." British Journal of Surgery 108, no. 12 (November 17, 2021): 1409–16. http://dx.doi.org/10.1093/bjs/znab364.

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Abstract Background The pressure on liver-transplant programmes has expanded the usage of extended-criteria allografts. Machine perfusion may be better than conventional static cold storage (SCS) in alleviating ischaemia–reperfusion injury in this setting. Recipient outcomes with hypothermic or normothermic machine perfusion were assessed against SCS here. Methods A search in MEDLINE, EMBASE and Scopus was conducted in February 2021. Primary studies investigating ex vivo machine perfusion were assessed for the following outcomes: morbidity, ICU and hospital stay, graft and patient survival rates and relative costs. Meta-analysis was performed to obtain pooled summary measures. Results Thirty-four articles involving 1742 patients were included, of which 20 were used for quantitative synthesis. Odds ratios favoured hypothermic machine perfusion (over SCS) with less early allograft dysfunction, ischaemic cholangiopathy, non-anastomotic strictures and graft loss. Hypothermic machine perfusion was associated with a shorter hospital stay and normothermic machine perfusion with reduced graft injury. Two randomized clinical trials found normothermic machine perfusion reduced major complication risks. Conclusion Machine perfusion assists some outcomes with potential cost savings.

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Lignell, Stina, Stine Lohmann, Kaithlyn M. Rozenberg, Henri G. D. Leuvenink, Merel B. F. Pool, Kate R. Lewis, Cyril Moers, et al. "Improved Normothermic Machine Perfusion After Short Oxygenated Hypothermic Machine Perfusion of Ischemically Injured Porcine Kidneys." Transplantation Direct 7, no. 2 (January 15, 2021): e653. http://dx.doi.org/10.1097/txd.0000000000001108.

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19

Treckmann, Jürgen, Cyril Moers, Jacqueline M. Smits, Anja Gallinat, Ina Jochmans, Jean-Paul Squifflet, Jacques Pirenne, Rutger J. Ploeg, and Andreas Paul. "Machine perfusion in clinical trials: “machine vs. solution effects”." Transplant International 25, no. 5 (March 15, 2012): e69-e70. http://dx.doi.org/10.1111/j.1432-2277.2012.01460.x.

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20

Large, Stephen, and Simon Messer. "Machine Perfusion of the Human Heart." Transplantology 3, no. 1 (March 18, 2022): 109–14. http://dx.doi.org/10.3390/transplantology3010011.

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This brief communication about machine perfusion of potential human donor hearts describes its historical development. Included in the review are both the isolated perfusion of donor hearts retrieved from heart beating and non-heart-beating donors. Additionally, some detail of in-situ (within the donor body) normothermic regional reperfusion of the heart and other organs is given. This only applies to the DCD donor heart. Similarly, some detail of ex-situ (outside the body) heart perfusion is offered. This article covers the entire history of the reperfusion of donor hearts. It takes us up to the current day describing 6 years follow-up of these donor machine perfused hearts. These clinical results appear similar to the outcomes of heart beating donors if reperfusion is managed within 30 min of normothermic circulatory determined death. Future developments are also offered. These are 3-fold and include: i. the pressing need for objective markers of the clinical outcome after transplantation, ii. the wish for isolated heart perfusion leading to improvement in donor heart quality, and iii. a strategy to safely lengthen the duration of isolated heart perfusion.

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Peltz, Matthias, David H. Rosenbaum, LaShondra West, Michael L. Cobert, and Michael E. Jessen. "1. Myocardial Perfusion Characteristics During Machine Perfusion for Heart Transplantation." Journal of Surgical Research 144, no. 2 (February 2008): 175. http://dx.doi.org/10.1016/j.jss.2007.12.002.

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22

Croome, Kristopher P. "Introducing Machine Perfusion into Routine Clinical Practice for Liver Transplantation in the United States: The Moment Has Finally Come." Journal of Clinical Medicine 12, no. 3 (January 23, 2023): 909. http://dx.doi.org/10.3390/jcm12030909.

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While adoption of machine perfusion technologies into clinical practice in the United States has been much slower than in Europe, recent changes in the transplant landscape as well as device availability following FDA approval have paved the way for rapid growth. Machine perfusion may provide one mechanism to maximize the utilization of potential donor liver grafts. Indeed, multiple studies have shown increased organ utilization with the implementation of technologies such as ex-situ normothermic machine perfusion (NMP), ex-situ hypothermic machine perfusion (HMP) and in-situ normothermic regional perfusion (NRP). The current review describes the history and development of machine perfusion utilization in the Unites States along with future directions. It also describes the differences in landscape between Europe and the United States and how this has shaped clinical application of these technologies.

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Lascaris, Bianca, Adam M. Thorne, Ton Lisman, Maarten W. N. Nijsten, Robert J. Porte, and Vincent E. de Meijer. "Long-term normothermic machine preservation of human livers: what is needed to succeed?" American Journal of Physiology-Gastrointestinal and Liver Physiology 322, no. 2 (February 1, 2022): G183—G200. http://dx.doi.org/10.1152/ajpgi.00257.2021.

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Although short‐term machine perfusion (≤24 h) allows for resuscitation and viability assessment of high‐risk donor livers, the donor organ shortage might be further remedied by long‐term perfusion machines. Extended preservation of injured donor livers may allow reconditioning, repairing, and regeneration. This review summarizes the necessary requirements and challenges for long‐term liver machine preservation, which requires integrating multiple core physiological functions to mimic the physiological environment inside the body. A pump simulates the heart in the perfusion system, including automatically controlled adjustment of flow and pressure settings. Oxygenation and ventilation are required to account for the absence of the lungs combined with continuous blood gas analysis. To avoid pressure necrosis and achieve heterogenic tissue perfusion during preservation, diaphragm movement should be simulated. An artificial kidney is required to remove waste products and control the perfusion solution’s composition. The perfusate requires an oxygen carrier, but will also be challenged by coagulation and activation of the immune system. The role of the pancreas can be mimicked through closed‐loop control of glucose concentrations by automatic injection of insulin or glucagon. Nutrients and bile salts, generally transported from the intestine to the liver, have to be supplemented when preserving livers long term. Especially for long‐term perfusion, the container should allow maintenance of sterility. In summary, the main challenge to develop a long‐term perfusion machine is to maintain the liver’s homeostasis in a sterile, carefully controlled environment. Long‐term machine preservation of human livers may allow organ regeneration and repair, thereby ultimately solving the shortage of donor livers.

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24

Prudhomme, Thomas, Delphine Kervella, Stéphanie Le Bas-Bernardet, Diego Cantarovich, Georges Karam, Gilles Blancho, and Julien Branchereau. "Ex situ Perfusion of Pancreas for Whole-Organ Transplantation: Is it Safe and Feasible? A Systematic Review." Journal of Diabetes Science and Technology 14, no. 1 (August 13, 2019): 120–34. http://dx.doi.org/10.1177/1932296819869312.

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Introduction: Pancreas transplantation is currently one of the best treatments proposed in highly selected patients with unstable and brittle type 1 diabetes. The objective of pancreas transplantation is to restore normoglycemia and avoid the occurrence of complications associated with diabetes. Graft pancreatitis and thrombosis, arising from ischemia reperfusion injuries, are major causes of graft loss in the postoperative period. Ex situ perfusion, in hypothermic or normothermic settings, allowed to improve ischemic reperfusion injury in other organ transplantations (kidney, liver, or lung). The development of pancreatic graft perfusion techniques would limit these ischemic reperfusion injuries. Objective: Evaluation of the safety and feasibility of ex situ perfusion of pancreas for whole-organ transplantation. Methods: English literature about pancreas perfusion was analyzed using electronic database Medline via PubMed (1950-2018). Exclusion criteria were studies that did not specify the technical aspects of machine perfusion and studies focused only on pancreas perfusion for islet isolation. Results: Hypothermic machine perfusion for pancreas preservation has been evaluated in nine studies and normothermic machine perfusion in ten studies. We evaluated machine perfusion model, types of experimental model, anatomy, perfusion parameters, flushing and perfusion solution, length of perfusion, and comparison between static cold storage and perfusion. Conclusions: This review compared ex vivo machine perfusion of experimental pancreas for whole-organ transplantation. Pancreas perfusion is feasible and could be a helpful tool to evaluate pancreas prior to transplantation. Pancreas perfusion (in hypothermic or normothermic settings) could reduce ischemic reperfusion injuries, and maybe could avoid pancreas thrombosis and reduce morbidity of pancreas transplantation.

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Lindell, Susanne L., Heather Muir, John Brassil, and Martin J. Mangino. "Hypothermic Machine Perfusion Preservation of the DCD Kidney: Machine Effects." Journal of Transplantation 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/802618.

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Purpose. Kidneys from DCD donors represent a significant pool, but preservation problems exist. The study objective was to test the importance of machine type for hypothermic preservation of DCD kidneys.Methods. Adult Beagle dog kidneys underwent 45 minutes of warm in situ ischemia followed by hypothermic perfusion for 24 hours (Belzer-MPS Solution) on either an ORS LifePort or a Waters RM3 using standard perfusion protocols. Kidneys were then autotransplanted, and renal function was assessed over 7 days following contralateral nephrectomy.Results. Renal vascular resistance was not different between the two pumps. After 24 hours, the oxygen partial pressure and oxygen delivery in the LifePort perfusate were significantly lower than those in the RM3 but not low enough to change lactate production. TheLifePort ran significantly colder than RM3 (2° versus 5°C). The arterial pressure waveform of the RM3 was qualitatively different from the waveform of the LifePort. Preservation injury after transplantation was not different between the devices. When the LifePort was changed to nonpulsatile flow, kidneys displayed significantly greater preservation injury compared to RM3.Conclusions. Both LifePort and RM3 can be used for hypothermic machine perfusion preservation of DCD kidneys with equal outcomes as long as the duty cycle remains pulsatile.

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26

Gao, Junda, Kang He, Qiang Xia, and Jianjun Zhang. "Research progress on hepatic machine perfusion." International Journal of Medical Sciences 18, no. 9 (2021): 1953–59. http://dx.doi.org/10.7150/ijms.56139.

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27

Schlegel, Andrea, Xavier Muller, and Philipp Dutkowski. "Machine perfusion strategies in liver transplantation." HepatoBiliary Surgery and Nutrition 8, no. 5 (October 2019): 490–501. http://dx.doi.org/10.21037/hbsn.2019.04.04.

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Furtado, Ruelan, Laurence Weinberg, and Marcos Vinicius Perini. "Liver Machine Perfusion—When Physiopathology Matters." Journal of Clinical Medicine 11, no. 17 (August 31, 2022): 5124. http://dx.doi.org/10.3390/jcm11175124.

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29

Raigani, Siavash, and Heidi Yeh. "Taking the Temperature on Machine Perfusion." Current Transplantation Reports 8, no. 3 (July 15, 2021): 241–49. http://dx.doi.org/10.1007/s40472-021-00337-y.

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30

Schlegel, Andrea, Philipp Kron, and Philipp Dutkowski. "Hypothermic machine perfusion in liver transplantation." Current Opinion in Organ Transplantation 21, no. 3 (June 2016): 308–14. http://dx.doi.org/10.1097/mot.0000000000000303.

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31

De Deken, Julie, Peri Kocabayoglu, and Cyril Moers. "Hypothermic machine perfusion in kidney transplantation." Current Opinion in Organ Transplantation 21, no. 3 (June 2016): 294–300. http://dx.doi.org/10.1097/mot.0000000000000306.

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32

Weissenbacher, Annemarie, and James Hunter. "Normothermic machine perfusion of the kidney." Current Opinion in Organ Transplantation 22, no. 6 (December 2017): 571–76. http://dx.doi.org/10.1097/mot.0000000000000470.

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33

Cobert, Michael L., LaShondra M. West, and Michael E. Jessen. "Machine perfusion for cardiac allograft preservation." Current Opinion in Organ Transplantation 13, no. 5 (October 2008): 526–30. http://dx.doi.org/10.1097/mot.0b013e32830fdf9a.

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34

Dutkowski, P., O. de Rougemont, and P. A. Clavien. "Machine Perfusion for ‘Marginal’ Liver Grafts." American Journal of Transplantation 8, no. 5 (May 2008): 917–24. http://dx.doi.org/10.1111/j.1600-6143.2008.02165.x.

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35

Mergental, Hynek, and Garrett R. Roll. "Normothermic machine perfusion of the liver." Clinical Liver Disease 10, no. 4 (October 2017): 97–99. http://dx.doi.org/10.1002/cld.661.

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36

Karangwa, S., G. Panayotova, P. Dutkowski, R. J. Porte, J. V. Guarrera, and A. Schlegel. "Hypothermic machine perfusion in liver transplantation." International Journal of Surgery 82 (October 2020): 44–51. http://dx.doi.org/10.1016/j.ijsu.2020.04.057.

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37

Quillin, R. Cutler, and James V. Guarrera. "Hypothermic machine perfusion in liver transplantation." Liver Transplantation 24, no. 2 (January 29, 2018): 276–81. http://dx.doi.org/10.1002/lt.25004.

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38

Wettstein, Dániel, Mátyás Hamar, Orsolya Cseprekál, Szabolcs József Tóth, Balázs Rózsa, Ádám Remport, and Zoltán Máthé. "Szervkonzerválás gépi perfúzióval: új lehetőségek a hasi szervek transzplantációjában." Orvosi Hetilap 159, no. 46 (November 2018): 1882–90. http://dx.doi.org/10.1556/650.2018.31282.

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Abstract: Machine perfusion of marginal grafts might be a possible solution to organ shortage and a promising tool for reducing waiting list morbidity and mortality. In recent years, optimizing the circumstances of organ preservation prior to implantation via machine perfusion has become a hot topic of research. Machine perfusion offers a platform for organ reconditioning, assessment of cell viability and function, pharmacological preconditioning, prolongation of preservation time (ischemia time) and finally reducing graft injury. The objective of the new technology is to increase the pool of transplantable organs safely. Multicentric prospective studies have been evaluating the short and long term outcomes of different methods, however, several questions still remain unanswered. This review summarizes the recent advances in the field of machine perfusion, focusing on preclinical and clinical results. Machine perfusion seems to be a new milestone in the modern era of solid organ transplantation. Orv Hetil. 2018; 159(46): 1882–1890.

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Goumard, Claire, Célia Turco, Mehdi Sakka, Lynda Aoudjehane, Philippe Lesnik, Eric Savier, Filomena Conti, and Olivier Scatton. "Ex-Vivo Pharmacological Defatting of the Liver: A Review." Journal of Clinical Medicine 10, no. 6 (March 18, 2021): 1253. http://dx.doi.org/10.3390/jcm10061253.

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The ongoing organ shortage has forced transplant teams to develop alternate sources of liver grafts. In this setting, ex-situ machine perfusion has rapidly developed as a promising tool to assess viability and improve the function of organs from extended criteria donors, including fatty liver grafts. In particular, normothermic machine perfusion represents a powerful tool to test a liver in full 37 °C metabolism and add pharmacological corrections whenever needed. In this context, many pharmacological agents and therapeutics have been tested to induce liver defatting on normothermic machine perfusion with promising results even on human organs. This systematic review makes a comprehensive synthesis on existing pharmacological therapies for liver defatting, with special focus on normothermic liver machine perfusion as an experimental ex-vivo translational model.

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Karimian, Negin, Siavash Raigani, Viola Huang, Sonal Nagpal, Ehab O. A. Hafiz, Irene Beijert, Paria Mahboub, et al. "Subnormothermic Machine Perfusion of Steatotic Livers Results in Increased Energy Charge at the Cost of Anti-Oxidant Capacity Compared to Normothermic Perfusion." Metabolites 9, no. 11 (October 24, 2019): 246. http://dx.doi.org/10.3390/metabo9110246.

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There continues to be significant debate regarding the most effective mode of ex situ machine perfusion of livers for transplantation. Subnormothermic (SNMP) and normothermic machine perfusion (NMP) are two methods with different benefits. We examined the metabolomic profiles of discarded steatotic human livers during three hours of subnormothermic or normothermic machine perfusion. Steatotic livers regenerate higher stores of ATP during SNMP than NMP. However, there is a significant depletion of available glutathione during SNMP, likely due to an inability to overcome the high energy threshold needed to synthesize glutathione. This highlights the increased oxidative stress apparent in steatotic livers. Rescue of discarded steatotic livers with machine perfusion may require the optimization of redox status through repletion or supplementation of reducing agents.

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Roushansarai, Nicola Sariye, Andreas Pascher, and Felix Becker. "Innate Immune Cells during Machine Perfusion of Liver Grafts—The Janus Face of Hepatic Macrophages." Journal of Clinical Medicine 11, no. 22 (November 10, 2022): 6669. http://dx.doi.org/10.3390/jcm11226669.

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Machine perfusion is an emerging technology in the field of liver transplantation. While machine perfusion has now been implemented in clinical routine throughout transplant centers around the world, a debate has arisen regarding its concurrent effect on the complex hepatic immune system during perfusion. Currently, our understanding of the perfusion-elicited processes involving innate immune cells remains incomplete. Hepatic macrophages (Kupffer cells) represent a special subset of hepatic immune cells with a dual pro-inflammatory, as well as a pro-resolving and anti-inflammatory, role in the sequence of ischemia–reperfusion injury. The purpose of this review is to provide an overview of the current data regarding the immunomodulatory role of machine perfusion and to emphasize the importance of macrophages for hepatic ischemia–reperfusion injury.

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42

Hann, A., H. Lembach, A. Nutu, B. Dassanayake, S. Tillakaratne, S. C. McKay, A. P. C. S. Boteon, et al. "Outcomes of normothermic machine perfusion of liver grafts in repeat liver transplantation (NAPLES initiative)." British Journal of Surgery 109, no. 4 (February 15, 2022): 372–80. http://dx.doi.org/10.1093/bjs/znab475.

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Abstract Background Retransplantation candidates are disadvantaged owing to lack of good-quality liver grafts. Strategies that can facilitate transplantation of suboptimal grafts into retransplant candidates require investigation. The aim was to determine whether late liver retransplantation can be performed safely with suboptimal grafts, following normothermic machine perfusion. Methods A prospectively enrolled group of patients who required liver retransplantation received a suboptimal graft preserved via normothermic machine perfusion. This group was compared with both historical and contemporaneous cohorts of patient who received grafts preserved by cold storage. The primary outcome was 6-month graft and patient survival. Results The normothermic machine perfusion group comprised 26 patients. The historical (cold storage 1) and contemporaneous (cold storage 2) groups comprised 31 and 25 patients respectively. The 6-month graft survival rate did not differ between groups (cold storage 1, 27 of 31, cold storage 2, 22 of 25; normothermic machine perfusion, 22 of 26; P = 0.934). This was despite the normothermic machine perfusion group having significantly more steatotic grafts (8 of 31, 7 of 25, and 14 of 26 respectively; P = 0.006) and grafts previously declined by at least one other transplant centre (5 of 31, 9 of 25, and 21 of 26; P < 0.001). Conclusion In liver retransplantation, normothermic machine perfusion can safely expand graft options without compromising short-term outcomes.

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43

Pizanis, N., A. Dimitriou, A. Koch, G. Ayoub, P. Luedike, M. Papathanasiou, A. Ruhparwar, B. Schmack, A. Weymann, and M. Kamler. "Introduction of Machine Perfusion in Donor Hearts." Journal of Heart and Lung Transplantation 40, no. 4 (April 2021): S195. http://dx.doi.org/10.1016/j.healun.2021.01.567.

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44

Ghinolfi, Davide. "ISSUE INFORMATION: MACHINE PERFUSION IN ORGAN TRANSPLANTATION." European Journal of Transplantation 1, no. 1 (October 2022): 2–3. http://dx.doi.org/10.57603/ejt-002.

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45

Amin, Arpit, Guergana Panayotova, and James V. Guarrera. "Hypothermic machine perfusion for liver graft preservation." Current Opinion in Organ Transplantation 27, no. 2 (February 18, 2022): 98–105. http://dx.doi.org/10.1097/mot.0000000000000973.

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Hamar, Matyas, and Markus Selzner. "Ex-vivo machine perfusion for kidney preservation." Current Opinion in Organ Transplantation 23, no. 3 (June 2018): 369–74. http://dx.doi.org/10.1097/mot.0000000000000524.

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op den Dries, S., N. Karimian, and R. J. Porte. "Normothermic Machine Perfusion of Discarded Liver Grafts." American Journal of Transplantation 13, no. 9 (September 2013): 2504. http://dx.doi.org/10.1111/ajt.12374.

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Hameed, Ahmer M., Henry C. Pleass, Germaine Wong, and Wayne J. Hawthorne. "Maximizing kidneys for transplantation using machine perfusion." Medicine 95, no. 40 (October 2016): e5083. http://dx.doi.org/10.1097/md.0000000000005083.

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Bon, D., P. O. Delpech, N. Chatauret, T. Hauet, L. Badet, and B. Barrou. "Does machine perfusion decrease ischemia reperfusion injury?" Progrès en Urologie 24 (June 2014): S44—S50. http://dx.doi.org/10.1016/s1166-7087(14)70063-6.

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van Gulik, Thomas M., Maud Bessems, Marie-Claire Schreinemachers, Arelene K. van Vliet, and Benedict M. Doorschodt. "14. Hypothermic machine perfusion for organ preservation." Cryobiology 53, no. 3 (December 2006): 372–73. http://dx.doi.org/10.1016/j.cryobiol.2006.10.015.

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