Relevant bibliographies by topics / Macrocyclic synthesis

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Academic literature on the topic 'Macrocyclic synthesis'

Author: Grafiati
Published: 4 June 2021
Last updated: 2 February 2022

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Journal articles on the topic "Macrocyclic synthesis"

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Singh, Kartikey, and Rama Pati Tripathi. "An Overview on Glyco-Macrocycles: Potential New Lead and their Future in Medicinal Chemistry." Current Medicinal Chemistry 27, no. 20 (June 7, 2020): 3386–410. http://dx.doi.org/10.2174/0929867326666190227232721.

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Macrocycles cover a small segment of molecules with a vast range of biological activity in the chemotherapeutic world. Primarily, the natural sources derived from macrocyclic drug candidates with a wide range of biological activities are known. Further evolutions of the medicinal chemistry towards macrocycle-based chemotherapeutics involve the functionalization of the natural product by hemisynthesis. More recently, macrocycles based on carbohydrates have evolved a considerable interest among the medicinal chemists worldwide. Carbohydrates provide an ideal scaffold to generate chiral macrocycles with well-defined pharmacophores in a decorated fashion to achieve the desired biological activity. We have given an overview on carbohydrate-derived macrocycle involving their synthesis in drug design and discovery and potential role in medicinal chemistry.
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Kandemir, Hakan, Ibrahim F. Sengul, Naresh Kumar, and David StC Black. "Synthesis of Imine and Amine-Linked Macrocycles Containing Tris-Indoles." Australian Journal of Chemistry 70, no. 11 (2017): 1196. http://dx.doi.org/10.1071/ch17264.

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The synthesis of 21-membered imine- and amine-linked tris-indole macrocycles starting from 7-nitroethylindoles is described. The 7-nitroethylindoles are converted to 2,2′-diindolylmethanes and the nitro groups reduced to amino. The resulting diamines undergo reactions with indole-2,7-dicarbaldehydes to form the macrocyclic imines, which can subsequently be reduced to the macrocyclic amines.
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Merner, Bradley, Nirmal Mitra, and Caroline Merryman. "Highly Strained para-Phenylene-Bridged Macrocycles from Unstrained 1,4-Diketo Macrocycles." Synlett 28, no. 17 (August 22, 2017): 2205–11. http://dx.doi.org/10.1055/s-0036-1589081.

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The conversion of macrocyclic 1,4-diketones to highly strained para-phenylene rings has recently been reported by our laboratory. This synthetic strategy represents a non-cross-coupling-based approach to arene-bridged macrocycles, and an alternative to palladium- and nickel-mediated processes. In this Synpacts article we discuss the development of endgame aromatization protocols for the synthesis of increasingly strained arene systems, as well as potential advantages of the macrocyclic 1,4-diketone approach to selectively functionalized benzenoid macrocycles for future complexity building reactions.1 Introduction2 A Non-Cross-Coupling-Based Approach to Arene-Bridged Macro cycles3 Macrocyclic 1,4-Diketones: Streamlined Synthesis and Size-­Dependent Diastereoselective Grignard Reactions4 Dehydrative Aromatization Reactions: A Powerful Tool for Synthesizing Highly Strained para-Phenylene Units5 Conclusion
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Lodeiro, Carlos, Rufina Bastida, Emilia Bértolo, and Adolfo Rodríguez. "A new family of NxOy pyridine-containing macrocycles: Synthesis and characterization of their Y(III), Ln(III), Zn(II), and Cd(II) coordination compounds." Canadian Journal of Chemistry 82, no. 3 (March 1, 2004): 437–47. http://dx.doi.org/10.1139/v03-214.

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Reaction between 2,6-bis(2-formylphenoxymethyl)pyridine and N,N-bis(3-aminopropyl)methylamine or tris(2-aminoethyl)amine has been used as the starting point for the synthesis of seven oxa-aza macrocyclic ligands, five of them never reported previously. They all feature different pendant arms, which provide a wide range of coordination possibilities. The Schiff base macrocycles L1 and L4 and their reduced ligands L2 and L5 are derived from 2,6-bis(2-formylphenoxymethyl)pyridine and tris(2-aminoethyl)amine or N,N-bis(3-aminopropyl)methylamine, respectively. The reaction of L1 with salicylaldehyde forms L3, which features an imine bond in the pendant arm. The ligand L5 has been the precursor for the pendant-armed L6 and L7, by alkylation of the free NH groups with methyl-imidazole or methyl-indole. By a template or a nontemplate approach, we have synthesized different mono- and dinuclear complexes with Y(III), Ln(III), Zn(II), and Cd(II) cations. Both the free macrocyclic ligands and their corresponding metal complexes have been characterized by microanalysis, IR, UV–vis, 1H and 13C NMR spectroscopy, FAB mass spectrometry, MS electrospray, and conductivity measurements.Key words: Schiff-base macrocycle, template synthesis, macrocyclic ligand complexes, lanthanide(III) complexes.
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Batiste, Suzanne M., and Jeffrey N. Johnston. "Rapid synthesis of cyclic oligomeric depsipeptides with positional, stereochemical, and macrocycle size distribution control." Proceedings of the National Academy of Sciences 113, no. 52 (December 14, 2016): 14893–97. http://dx.doi.org/10.1073/pnas.1616462114.

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Macrocyclic small molecules are attractive tools in the development of sensors, new materials, and therapeutics. Within early-stage drug discovery, they are increasingly sought for their potential to interact with broad surfaces of peptidic receptors rather than within their narrow folds and pockets. Cyclization of linear small molecule precursors is a straightforward strategy to constrain conformationally mobile motifs, but forging a macrocycle bond typically becomes more difficult at larger ring sizes. We report the development of a general approach to discrete collections of oligomeric macrocyclic depsipeptides using an oligomerization/macrocyclization process governed by a series of Mitsunobu reactions of hydroxy acid monomers. Ring sizes of 18, 24, 30, and 36 are formed in a single reaction from a didepsipeptide, whereas sizes of 24, 36, and 60 result from a tetradepsipeptide. The ring-size selectivity inherent to the approach can be modulated by salt additives that enhance the formation of specific ring sizes. Use of chemical synthesis to prepare the monomers suggests broad access to functionally and stereochemically diverse collections of natural product-like oligodepsipeptide macrocycles. Two cyclodepsipeptide natural products were prepared along with numerous unnatural oligomeric congeners to provide rapid access to discrete collections of complex macrocyclic small molecules from medium (18) to large (60) ring sizes.
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Moon, Dohyun, Yong Pyo Hong, and Jong-Ha Choi. "Spectroscopic characterization and molecular structure of 3,14-dimethyl-2,6,13,17-tetraazapentacyclo[16.4.0.12,17.16,13.07,12]tetracosane." Acta Crystallographica Section C Structural Chemistry 72, no. 9 (August 25, 2016): 701–4. http://dx.doi.org/10.1107/s2053229616013280.

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Constrained cyclam derivatives have been found to exhibit anti-HIV effects. The strength of binding to the CXCR4 receptor correlates with anti-HIV activity. The conformation of the macrocyclic compound is very important for co-receptor recognition. Therefore, knowledge of the conformation and crystal packing of macrocycles has become important in developing new highly effective anti-HIV drugs. Structural modifications of N-functionalized polyaza macrocyclic compounds have been achieved using various methods. A new synthesis affording single crystals of the title tetraazapentacyclo[16.4.0.12,17.16,13.07,12]tetracosane macrocycle, C22H40N4, is reported. Formaldehyde reacts readily at room temperature with the tetraazatricyclo[16.4.0.02,17]docosane precursor to yield a macropolycycle containing two five-membered rings. Characterization by elemental, spectroscopic and single-crystal X-ray diffraction analyses shows that the asymmetric unit contains half of a centrosymmetric molecule. The molecular structure shows atransconformation for the two methylene bridges owing to molecular symmetry. The crystal structure is stabilized by intramolecular C—H...N hydrogen bonds. NMR and IR spectroscopic properties support the methylene-bridged macrocyclic structure.
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Liu, Na, Xing Wang, Hui Cao, Chun Hai Chen, and Wan Jin Zhang. "Synthesis of a Novel Hollow Sphere Having Rigid Binaphthyl Macrocycle as Shell." Solid State Phenomena 121-123 (March 2007): 219–22. http://dx.doi.org/10.4028/www.scientific.net/ssp.121-123.219.

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A novel hollow sphere having rigid binaphthyl macrocycle as shell was prepared by means of sacrifice the silica core. The synthesis of hollow sphere from rigid colloidal silica particles occurs in three steps: a) modification of silica particles with vinyltriethoxysilane as coupling agent, b) immersion in the solution of monomer having rigid binaphthyl macrocycle and polymerization, and c) removal of silica particles. These macrocycles contained in the shell of hollow spheres belong to an important class of host-guest macrocyclic material in which the rigid backbone and C2 symmetry of the binaphthyl unit play an important role in complexing guest molecules. This will endow hollow sphere with new opportunities in molecular recognition and separation.The morphology of colloidal silica particles and hollow spheres was characterized by SEM and TEM.
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Pomarico, Giuseppe, Manuela Stefanelli, Sara Nardis, Sara Lentini, Daniel O. Cicero, Gregory T. McCandless, Kevin M. Smith, and Roberto Paolesse. "Synthesis and functionalization of β-alkyl-meso-triarylcorroles." Journal of Porphyrins and Phthalocyanines 19, no. 07 (July 2015): 865–73. http://dx.doi.org/10.1142/s1088424615500613.

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After the definition of efficient synthetic routes for the preparation of triarylcorroles, the functionalization of these macrocycles is becoming a necessary and challenging field of research. One important synthetic step is the introduction of substituents able to influence the electronic distribution in the macrocyclic ring. A valuable target would be a corrole macrocycle with some β-pyrrole positions occupied by methyl groups, while exploiting other positions to introduce electron-withdrawing substituents. To explore the scope of this approach, we investigated the bromination and the nitration of the corrole ring and the desired products have been obtained in moderate to good yield. The successful preparation of selectively halogenated corroles is particularly interesting since they are suitable substrates for the preparation of more complex partially alkylated structures using modern cross coupling methodologies.
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Chmielewski, Michał J., Tomasz Zieliński, and Janusz Jurczak. "Synthesis, structure, and complexing properties of macrocyclic receptors for anions." Pure and Applied Chemistry 79, no. 6 (January 1, 2007): 1087–96. http://dx.doi.org/10.1351/pac200779061087.

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Understanding of structure-affinity relationships is crucial for rational receptor design, however, such studies for anion receptors are still limited. Therefore, we investigated this issue in the case of amide-based macrocyclic receptors derived from aromatic diacids (i.e., isophthalic and dipicolinic). Using these model compounds, we examined the macrocyclic effect, the influence of intramolecular hydrogen bonds, and the correlation between the ring size and anion affinity. We found that in contrast to what was known for acyclic diamides, macrocyclic isophthalamide receptors bind anions more weakly than their dipicolinic analogs. Comprehensive structural studies revealed that such behavior is due to intramolecular hydrogen bonds present in isophthalamide receptors. Furthermore, we demonstrated how this obstacle can be overcome by the preparation of a hybrid macrocycle based on both building blocks.
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Srinivas, Avula, and Enugala Kalyan Rao. "Synthesis and Anticancer Activity of Triazole Linked Macrocycles and Heterocycles." Acta Chimica Slovenica 68, no. 2 (June 15, 2021): 404–13. http://dx.doi.org/10.17344/acsi.2020.6466.

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Synthesis of macrocylic enones starting from alkyl ether and triazole as a linker was achieved using click reaction and intramolecular aldol condensation. The newly synthesized macrocyclic enone was successfully utilized as a dipolarophile in 1,3-dipolar cycloaddition. The dipoles generated from hydrazine hydrochloride, hydroxylamine and guanidine hydrochloride were reacted with macrocyclic enone to give a new class of spiro aminopyrimidines, phenyl pyrazoles and isoxazoles grafted macrocycles in good yield. The structures of newly synthesized compounds were confirmed with IR, NMR and mass spectroscopy and evaluated for their anti cancer activity.
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Dissertations / Theses on the topic "Macrocyclic synthesis"

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Qu, Wenchao. "SYNTHESIS OF FUNCTIONALIZED MACROCYCLIC POLYTHIAETHERS." University of Akron / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=akron1137687463.

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Smith, Richard John Alan. "The synthesis of macrocyclic receptor compounds." Thesis, University of Liverpool, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.328435.

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Lermer, Leonard. "Synthesis and reactivity of macrocyclic lactams and dynamic NMR studies of macrocyclic amines and a macrocyclic ketone." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0023/NQ38926.pdf.

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Atkins, Andrew J. "Studies on transition metal macrocyclic complexes." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/11664.

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Bukhari, Abeer. "Towards the synthesis of new macrocyclic receptors." Thesis, University of Manchester, 2017. https://www.research.manchester.ac.uk/portal/en/theses/towards-the-synthesis-of-new-macrocyclic-receptors(0bf6fd45-d433-4057-a77a-3dd4e93259ac).html.

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Iron plays a fundamental role in the regulation of chemical processes within biological systems and the control of intracellular iron concentration has important consequences in the aetiology of a variety of disease states (e.g. neurodegenerative disorders). In this thesis, which is concerned with the identification of new macrocyclic receptors, the synthesis of (N,N',N''-((3S,7S,11S)-2,6,10-trioxo-1,5,9-trioxacyclododecane-3,7,11-triyl)tris(2,3-dihydroxybenzenesulfonamide), a mimic to the natural siderophore enterochelin, is reported. Two synthetic routes to the preparation of this macrocycle are presented where a sulfonamide residue is attached to a functionalised lactone core. The title compound was prepared either via the cyclotrimerzation of methyl N-((2,3-dimethoxyphenyl)sulfonyl)-L-serinate (“pre-functionalization” method) or by the elaboration of a preformed macrocyclic scaffold, (3S,7S,11S)-2,6,10-trioxo-1,5,9-trioxacyclododecane-3,7,11-triaminium chloride, with 2,3-dimethoxybenzenesulfonyl chloride (“post-functionalization” method). Late-stage demethylation of the macrocyle formed in these reactions - N,N’,N’’-((3S,7S,11S)-2,6,10-trioxo-1,5,9-trioxacyclododecane-3,7,11-triyl)tris(2,3-dimethoxybenzenesulfonamide) using BBr3 afforded the desired enterochelin analogue. These studies indicated that the “post-functionalisation” protocol afforded higher yields of the desired macrocycle in a process which was not marred by the concomitant formation of sulphonamide by-products. During the synthesis of 2,3-diacetoxy-5,6-dimethylsulfonyl chloride, a key intermediate for the assembly of functionalised sulphonamide siderophores, an ortho-quinone intermediate was found to undergo an intermolecular Diels-Alder reaction from which both the keto- ((1S*,4S*,4aR*,8aS*)-2,3,8,8a-tetramethyl-1,4,4a,8a-tetrahydro-1,4-ethanonaphthalene-5,6,9,10-tetraone) and enol- ((1S*,4R*,8aS*)-5-hydroxy-2,3,8,8a-tetramethyl-1,8a-dihydro-1,4-ethanonaphthalene-6,9,10(4H)-trione) tautomeric forms could be isolated and fully characterised by X-ray crystallography thereby constituting a rare example of desmotropy.
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Goodwin-Tindall, Jake. "Synthesis of the macrocyclic core of (-)-rhizopodin." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648323.

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White, Marcus James. "Synthesis and reactions of macrocyclic thiazolium salts." Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621429.

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Roka, Eszter. "Biocompatibility evaluation and synthesis of macrocyclic compounds." Thesis, Lyon, 2017. http://www.theses.fr/2017LYSE1027/document.

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La faible solubilité de certains médicaments cause des problèmes majeurs dans les formulations pharmaceutiques, puisque la solubilité dans l'eau est un critère indispensable pour la biodisponibilité. Les composés macrocycliques tels que les CDs et les calixarènes ont une cavité relativement hydrophobe, leur permettant ainsi d'encapsuler de nombreuses molécules. Les CDs ont déjà été utilisées comme excipients pharmaceutiques pour l'amélioration de la solubilité. La structure de ces macrocycles permet d'effectuer de nombreuses modifications, qui causent des changements tant au niveau de leurs caractéristiques physico-chimiques que sur leurs effets sur les organismes vivants. Ainsi, l'évaluation de la biocompatibilité de ces dérivés est primordiale en vue de leur utilisation en pharmacie. Puisque l'étude de la biocompatibilité de plusieurs dérivés de β-CD a déjà été étudiée, l'objectif de cette recherche était d'étendre ces expériences à des dérivés de l'α-CD qui sont disponibles dans le commerce. Nous nous sommes intéressés aux relations entre structure et toxicité. Ainsi les dérivés alkyl éther d'α-CD, avec des chaînes alkyle de longueur croissante et substitués sur différentes positions, ont été synthétisés et leur toxicité étudiée. Les para-sulphonato-calix[n]-arènes quant à eux, ont souvent été étudiés et ont montré une forte capacité à complexer de nombreux médicaments. Ils ont aussi démontré une activité biologique polyvalente. Néanmoins, leurs effets sur le mécanisme de transport paracellulaire n'a jamais été évaluée. Les tests de viabilité cellulaire et d'hémolyse nous ont permis d'une part de classer les α-CDs et de choisir les dérivés les plus sûrs, et d'autre part de comparer leur effets toxiques dans des systèmes différents. La comparaison des α- et ß-CDs portant les mêmes modifications chimiques nous a montré l'importance du nombre d'unités de construction. Le rapport entre l'effet cytotoxique et le nombre de groupes hydroxyles libres est également très important. Les dérivés portant de longues chaînes alkyles possèdent une faible solubilité, ce qui nous a conduits vers d'autres modifications chimiques : la sulfonation de ces derniers dérivés semble avoir un impact bénéfique sur la biocompatibilité de CDs. Elle a aussi amélioré la solubilité des calixarènes. Les calix[4] et [8]arène sulphonates ont prouvé leur effet positif sur l'absorption paracellulaire, tandis que le calix[6]arène sulphonate n'a pas eu d'effet similaire. Notre recherche conclut que les changements structurels sur les anneaux macrocycliques peuvent avoir un impact majeur sur la biocompatibilité. Comme les possibilités de modification sont pratiquement illimitées, l'évaluation de la structure et de l'activité est indispensable pour faciliter les choix les plus sûrs dans les applications pharmaceutiques à venir
The low solubility of drug candidates cause a major problem in pharmaceutical formulations, as the aqueous solubility is an indispensable criterion for appropriate bioavailability. Macrocyclic compounds possess a relatively hydrophobic cavity, which is suitable for guest molecule inclusion. Cyclodextrins and calixarenes are widely studied organic host-compounds, and CDs have already been used as pharmaceutical excipients for solubility enhancement. The macrocycles’ chemical structure allows their versatile modification, which eventuates changes not only in physicochemical characteristics, but in their effects on living organisms, as well. Thus, the biocompatibility evaluation of the derivatives is fundamental. Owing to the already performed assessment of numerous β-CD derivatives’ biocompatibility, the aim of this research was to extend these experiments to commercially available α-CDs. They have been used less frequently, however several derivatives, which have not been tested yet in vitro, have the possibility of future pharmaceutical use. Their importance is also certified by their benefits in nanoparticle formation. We have been interested in concrete structure-toxicity correlations, thus alkyl ether α-CD derivatives were synthetized bearing increasing length alkyl chains, in different positions. Para-sulphonato-calix[n]-arenes have already been widely examined due to their efficient drug complexation and versatile biological activity, however, their effects on paracellular transport mechanism have not been evaluated until now.The cell viability and hemolysis tests have allowed us to rank the α-CDs and to choose the safest derivatives, also to compare their toxic effects in different systems. The comparison of α- and β-CDs bearing the same chemical modifications highlighted the importance of the number of building units. Important information has been evaluated regarding the connection between the cytotoxic effect and the number of free hydroxyl groups. Derivatives with long alkyl chains possess low solubility, which led us towards further chemical modifications. Sulfonation seemed to have beneficial impact on the biocompatibility. Sulfonation also improved the solubility of calixarenes. C4S and C8S proved their positive effect on paracellular absorption in a non-toxic concentration range, however C6S had no similar effect, thus their behaviour in in vitro absorption model system arose forward-looking questions.Our research concludes, that the structural changes on the macrocyclic rings may have major impact on the biocompatibility. As the modification possibilities are practically unlimited, the evaluation of structure and activity cannot be avoided, facilitating the safest choice for further pharmaceutical use
A gyógyszerhatóanyagok rossz vízoldékonysága nagy kihívást jelent formulálásuk során, ugyanis a vízoldékonyság elengedhetetlen feltétele a megfelelő biohasznosulásnak. A makrociklusos vegyületek belső ürege viszonylag hidrofób, ez alkalmassá teszi őket vendégmolekulákkal való komplexképzésre. A ciklodextrinek és kalixarének széles körben tanulmányozott vegyületek, egyes CD-ek bejegyzett oldékonyságnövelő segédanyagok. A makrociklusok felépítése számos kémiai módosításra ad lehetőséget, amelyek nem csupán a fiziko-kémiai tulajdonságok változását eredményezik, hanem az élő organizmusokra kifejtett hatásokat is módosítják. Ezen származékok biokompatibilitás vizsgálata tehát elengedhetetlen. Számos β-CD származék biokompatibilitása ismert már, így kutatásunk célul tűzte ki ezen vizsgálatok α-CD-ekre történő kiterjesztését. Az α-CD-ek alkalmazása ritkább, azonban vannak származékok, amelyek in vitro vizsgálata még nem történt meg, de jelentőségük a nanopartikulum-képzésben már igazolt. A szerkezet-toxicitás összefüggések feltárása érdekében olyan alkil-éter CD származékokat szintetizáltunk, amelyek növekvő szénatomszámú alkil-csoportokkal rendelkeznek, eltérő pozíciókban. A para-szulfonáto-kalix[n]aréneket hatóanyag-komplexáló tulajdonságuk, valamint sokoldalú biológiai aktivitásuk miatt széles körben tanulmányozták már, azonban a paracelluláris anyagtranszportra gyakorolt hatásuk ezidáig még nem volt ismert. A sejtéletképességi és hemolízis vizsgálatok hozzásegítettek az egyes α-CD-ek rangsorolásához, továbbá a vegyületek különböző rendszerekben mért toxikussága is összevethetővé vált. A megegyező kémiai módosításokon átesett α- és β-CD-ek biokompatibilitása rávilágított a CD-gyűrű mértének jelentőségére. Egyértelmű összefüggést fedeztünk fel a toxicitás és a szabad hidroxil-csoportok száma között. A hosszú alkil-csoporttal rendelkező CD-ek rossz oldékonysága további kémiai módosításokat tett szükségszerűvé; a szulfát csoportok jelenléte jótékony hatással volt az oldhatóságra, és a citotoxicitásra is. A szulfatálás a kalixarének oldékonyságát is növelte. A C4S és C8S vegyületek növelték a paracelluláris felszívódás mértékét szubtoxikus koncentrációban, azonban a C6S nem mutatott hasonló hatást. Ezen eredmények további kérdéseket vetnek fel a pontos hatásmechanizmusról. Eredményeink rávilágítanak a makrociklusok szerkezetének és biokompatibilitásának összefüggéseire, valamint ezen ismeretek fontosságára annak érdekében, hogy minden formulációban a legbiztonságosabb segédanyagok legyenek alkalmazhatóak
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Tran, Khoa V. "Spectroscopic studies of tetranuclear Pd(II) and Pt(II) macrocyclic square complexes." Virtual Press, 2000. http://liblink.bsu.edu/uhtbin/catkey/1191722.

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Two macrocyclic squares (one with four Pd 21 corners, the other with four Pte+ corners) were synthesized according to literature methods."2 The charge-transfer complexes which formed when each were mixed with a bis(thiol)hydroquinone were then studied by UV-VIS, NMR, and IR spectroscopy. The UV-VIS data obtained indicated a stoichiometric relationship of I mole of molecular square to 2 moles of dithiol and a very large binding constant. Further evidence for the association between each macrocyclic square and the dithiol was observed in the NMR spectrum by the shifting of the proton resonances on the bipyridine unit of the molecular square and in the IR spectra by the changes in the aromatic ring absorptions of the dithiol and the bipyridine ring absorptions of the square.A monolayer formed on gold from a dilute solution of the dithiol in ethanol and a monolayer formed from a dilute solution of a 6:1 ratio of molecular square to dithiol were each observed by infrared grazing angle spectroscopy. The spectrum of the dithiol monolayer indicated that the aromatic ring was oriented perpendicular to the gold surface. The infrared spectrum of the square/dithiol monolayer showed the presence of triflate absorptions and methyl stretches, suggesting the square was attached via a catanane formation. Furthermore, the spectral data indicated that upon formation of the catanane, the aromatic ring of the dithiol and the bipyridine rings of the square were oriented parallel to the gold surface.
Department of Chemistry
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10

Lacombe, Marie. "Synthesis and metal salt binding properties of functionalised macrocyclic ligands." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275160.

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Books on the topic "Macrocyclic synthesis"

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Gėrbėlėu, Nikolaĭ Vasilʹevich. Template synthesis of macrocyclic compounds. Weinheim: Wiley-VCH, 1999.

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Bailey, Simon. The synthesis of complex macrocyclic molecules. Manchester: University of Manchester, 1993.

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Griffin, J. L. W. The design, synthesis and application of macrocyclic receptors. Manchester: UMIST, 1998.

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Sikanyika, Harrison. The synthesis and co-ordination chemistry of redox-active macrocyclic receptor molecules. Birmingham: University of Birmingham, 1989.

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Spry, Marcus P. Synthesis and structural studies of macrocyclic complexes of the p-block (Sb, Ge, Te, O) and lanthanide (La, Ho, Er, Tm, Pr) elements. [s.l.]: typescript, 1999.

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6

Musau, R. M. The synthesis of furan-based macrocycles. Manchester: UMIST, 1994.

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7

Jones, Helen Ann. The syntheses of redox-active metallo-macrocycles. Birmingham: University of Birmingham, 1999.

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8

Harris, Craig S. The synthesis and properties of novel amide-based macrocycles and catenanes. Manchester: UMIST, 1997.

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9

Dorling, Kate. Applications of remote asymmetric induction to the synthesis of macrocycles: Towards PatulolideC. Manchester: University of Manchester, 1996.

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10

Reader, Charles James. Synthesis and study of new macrocycles and some of their transition metal complexes. [s.l.]: typescript, 1988.

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Book chapters on the topic "Macrocyclic synthesis"

1

Mohd Nor, Siti Mariam, Zhengshuang Xu, and Tao Ye. "Bioactive Macrocyclic Natural Products." In Heterocycles in Natural Product Synthesis, 569–619. Weinheim, Germany: Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527634880.ch16.

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Busch, Daryle H. "Synthesis of Macrocyclic Complexes Using Metal Ion Templates." In Macrocyclic and Supramolecular Chemistry, 383–87. Chichester, UK: John Wiley & Sons, Ltd, 2016. http://dx.doi.org/10.1002/9781119053859.ch19.

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Boeckman, R. K., and S. W. Goldstein. "The Total Synthesis of Macrocyclic Lactones." In Total Synthesis of Natural Products, 1–139. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2007. http://dx.doi.org/10.1002/9780470129708.ch1.

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Verbicky, J. W. "Condensation Macrocyclic Oligomers: Synthesis and Polymerization." In Progress in Pacific Polymer Science, 89–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 1991. http://dx.doi.org/10.1007/978-3-642-84115-6_12.

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Li, Bin, Yiliang Wang, and Chunju Li. "Biphen[n]arenes: Synthesis and Host–Guest Properties." In Handbook of Macrocyclic Supramolecular Assembly, 1–29. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-1744-6_13-1.

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Zhang, Siqi, and Liang Zhao. "Controllable Synthesis of Polynuclear Metal Clusters Within Macrocycles." In Handbook of Macrocyclic Supramolecular Assembly, 1–29. Singapore: Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-13-1744-6_49-1.

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Li, Bin, Yiliang Wang, and Chunju Li. "Biphen[n]arenes: Synthesis and Host–Guest Properties." In Handbook of Macrocyclic Supramolecular Assembly, 311–39. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-2686-2_13.

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Zhang, Siqi, and Liang Zhao. "Controllable Synthesis of Polynuclear Metal Clusters Within Macrocycles." In Handbook of Macrocyclic Supramolecular Assembly, 1223–51. Singapore: Springer Singapore, 2020. http://dx.doi.org/10.1007/978-981-15-2686-2_49.

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Böhmer, Volker, and Jacques Vicens. "Special Calixarenes, Synthesis and Properties." In Calixarenes: A Versatile Class of Macrocyclic Compounds, 39–62. Dordrecht: Springer Netherlands, 1991. http://dx.doi.org/10.1007/978-94-009-2013-2_2.

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Goeb, Sébastien, David Canevet, and Marc Sallé. "Supramolecular Redox Transduction: Macrocyclic Receptors for Organic Guests." In Organic Synthesis and Molecular Engineering, 213–56. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2013. http://dx.doi.org/10.1002/9781118736449.ch8.

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Conference papers on the topic "Macrocyclic synthesis"

1

Serra, Gloria, Stella Peña, Laura Scarone, and Eduardo Manta. "Synthesis of a Macrocyclic Marine Natural Product Analog." In 14th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-14bmos-r0079-1.

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Kulig, Joseph B., Collin G. Moore, William J. Brittain, Sandra Gilmour, and Joseph W. Perry. "Synthesis of NLO polycarbonates via the ring-opening polymerization of macrocyclic prepolymers." In OE/LASE '94, edited by Seth R. Marder and Joseph W. Perry. SPIE, 1994. http://dx.doi.org/10.1117/12.173809.

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Bt Safiin, Nurul Atikah, Ambar Yarmo, and Bohari M. Yamin. "Synthesis and characterization of two dimensional metal organic framework of cerium with tetraaza macrocyclic." In THE 2013 UKM FST POSTGRADUATE COLLOQUIUM: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2013 Postgraduate Colloquium. AIP Publishing LLC, 2013. http://dx.doi.org/10.1063/1.4858762.

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Xia, Hua, and Guanghui Tang. "Synthesis, crystal structure, and properties of a novel carboxylic acid functionalized porous coordination biopolymer based on macrocyclic complex." In International conference on Future Energy, Environment and Materials. Southampton, UK: WIT Press, 2014. http://dx.doi.org/10.2495/feem130631.

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Chavez, Medardo R., Zoltan Kovacs, and A. D. Sherry. "New route to macrocyclic-based phosphonate acetoxymethyl (AM)-esters: synthesis, cell loading, and 31P NMR." In BiOS '99 International Biomedical Optics Symposium, edited by Darryl J. Bornhop, Christopher H. Contag, and Eva M. Sevick-Muraca. SPIE, 1999. http://dx.doi.org/10.1117/12.351017.

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Vasilevich, Natalya, Anna Aksenova, Elena Aksenova, and Ilya Afanasyev. "Design and Synthesis of Macrocyclic Scaffolds for Compounds with Potential Antituberculosis/Antibacterial Activity and Improved CYP450 Properties." In 2nd International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2016. http://dx.doi.org/10.3390/ecmc-2-a013.

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Mariam, Siti Nor, Bohari M. Yamin, and Azizan Ahmad. "Synthesis of tetraaza bromide macrocyclic and studies of its effect on poly(methyl methacrylate) grafted natural rubber (MG49) - lithium tertrafluoroborate (LiBF4) films." In THE 2013 UKM FST POSTGRADUATE COLLOQUIUM: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2013 Postgraduate Colloquium. AIP Publishing LLC, 2013. http://dx.doi.org/10.1063/1.4858774.

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Lee, Angeline, Anthony William, Anders Poulsen, Evelyn Tan, Harish Nagaraj, Kay Lin Goh, Wai Chung Ong, et al. "Abstract 3564: Design, synthesis and SAR studies leading to SB1518, a novel macrocyclic JAK2/FLT3 inhibitor in phase 2 clinical trials for myelofibrosis and lymphoma." In Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1538-7445.am2011-3564.

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Shutalev, Anatoly, Anastasia Fesenko, Dmitry Albov, Vladimir Chernyshev, and Ilia Zamilatskov. "Novel 14-Membered Hexaaza Macrocycles." In The 18th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2014. http://dx.doi.org/10.3390/ecsoc-18-a042.

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Peña, S., L. Scarone, A. Medeiros, M. Comini, L. Stewart, V. Yardley, F. Albericio, and G. Serra. "First Total Synthesis of Aerucyclamide B and Macrocycle Analogs as Antimalarial and Anti-Trypanosomal Agents." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013813154124.

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Reports on the topic "Macrocyclic synthesis"

1

Clearfield, Abraham. The Synthesis, Structures, and Chemical Properties of Macrocyclic Ligands Covalently Bonded into Layered Arrays. Office of Scientific and Technical Information (OSTI), November 2014. http://dx.doi.org/10.2172/1164084.

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Abraham Clearfield. The Synthesis, Structures and Chemical Properties of Macrocyclic Ligands Covalently Bonded into Layered Arrays. Office of Scientific and Technical Information (OSTI), July 2009. http://dx.doi.org/10.2172/959123.

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Lin, Shirley. Synthesis of Main-chain Hybrid Polypseudorotaxanes with Controlled Macrocycle Sequence. Fort Belvoir, VA: Defense Technical Information Center, January 2007. http://dx.doi.org/10.21236/ada519776.

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