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Journal articles on the topic 'Macrophages/drug effects'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Fischer, Carrie D., Jennifer K. Beatty, Stephanie C. Duquette, Douglas W. Morck, Merlyn J. Lucas, and André G. Buret. "Direct and Indirect Anti-Inflammatory Effects of Tulathromycin in Bovine Macrophages: Inhibition of CXCL-8 Secretion, Induction of Apoptosis, and Promotion of Efferocytosis." Antimicrobial Agents and Chemotherapy 57, no. 3 (2013): 1385–93. http://dx.doi.org/10.1128/aac.01598-12.

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ABSTRACTRecent evidence indicates that immunomodulation by antibiotics may enhance their clinical efficacy. Specifically, drug-induced leukocyte apoptosis and macrophage efferocytosis have been shown to promote the resolution of inflammation in a variety of disease settings. Tulathromycin is a new macrolide antibiotic for the treatment of bovine respiratory disease. The direct antimicrobial effects of the drug alone do not fully justify its superior clinical efficacy, and we hypothesize that tulathromycin may have immunomodulating properties. We recently reported that tulathromycin promotes ap

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Kolawole, Abimbola Olayinka, and Fred Miller McCorkle. "Cyclophosphamide effects on avian macrophages in vitro (52.10)." Journal of Immunology 178, no. 1_Supplement (2007): S101. http://dx.doi.org/10.4049/jimmunol.178.supp.52.10.

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Abstract Cyclophosphamide is an alkylating agent used in the treatment of a variety of cancers. It has been shown to cause immunodepression by reducing T cell, B cell and antibody production, but little is known about the effects of the drug on macrophages. Avian macrophages are good models for human macrophages because they have the same functions in maintaining immunity. This study examined the cytotoxic effect of cyclophosphamide on the activated avian macrophage cell line MQ-NCSU, as well as the effects of the drug on attachment to a plastic substrate, phagocytosis, nitrite production and

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Davoodvandi, Amirhossein, Roxana Sahebnasagh, Omid Mardanshah, et al. "Medicinal Plants As Natural Polarizers of Macrophages: Phytochemicals and Pharmacological Effects." Current Pharmaceutical Design 25, no. 30 (2019): 3225–38. http://dx.doi.org/10.2174/1381612825666190829154934.

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Macrophages are one of the crucial mediators of the immune response in different physiological and pathological conditions. These cells have critical functions in the inflammation mechanisms that are involved in the inhibition or progression of a wide range of diseases including cancer, autoimmune diseases, etc. It has been shown that macrophages are generally divided into two subtypes, M1 and M2, which are distinguished on the basis of their different gene expression patterns and phenotype. M1 macrophages are known as pro-inflammatory cells and are involved in inflammatory mechanisms, whereas

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Dukhinova, Marina S., Artur Y. Prilepskii, Alexander A. Shtil, and Vladimir V. Vinogradov. "Metal Oxide Nanoparticles in Therapeutic Regulation of Macrophage Functions." Nanomaterials 9, no. 11 (2019): 1631. http://dx.doi.org/10.3390/nano9111631.

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Macrophages are components of the innate immune system that control a plethora of biological processes. Macrophages can be activated towards pro-inflammatory (M1) or anti-inflammatory (M2) phenotypes depending on the cue; however, polarization may be altered in bacterial and viral infections, cancer, or autoimmune diseases. Metal (zinc, iron, titanium, copper, etc.) oxide nanoparticles are widely used in therapeutic applications as drugs, nanocarriers, and diagnostic tools. Macrophages can recognize and engulf nanoparticles, while the influence of macrophage-nanoparticle interaction on cell po

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Kubick, Norwin, Marta Pajares, Ioana Enache, Gina Manda, and Michel-Edwar Mickael. "Repurposing Zileuton as a Depression Drug Using an AI and In Vitro Approach." Molecules 25, no. 9 (2020): 2155. http://dx.doi.org/10.3390/molecules25092155.

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Repurposing drugs to target M1 macrophages inflammatory response in depression constitutes a bright alternative for commonly used antidepressants. Depression is a significant type of mood disorder, where patients suffer from pathological disturbances associated with a proinflammatory M1 macrophage phenotype. Presently, the most commonly used antidepressants such as Zoloft and Citalopram can reduce inflammation, but suffer from dangerous side effects without offering specificity toward macrophages. We employed a new strategy for drug repurposing based on the integration of RNA-seq analysis and

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Dolmatova, Lyudmila S., and Igor Yu Dolmatov. "Different Macrophage Type Triggering as Target of the Action of Biologically Active Substances from Marine Invertebrates." Marine Drugs 18, no. 1 (2020): 37. http://dx.doi.org/10.3390/md18010037.

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Macrophages play a fundamental role in the immune system. Depending on the microenvironment stimuli, macrophages can acquire distinct phenotypes characterized with different sets of the markers of their functional activities. Polarization of macrophages towards M1 type (classical activation) is involved in inflammation and the related progression of diseases, while, in contrast, alternatively activated M2 macrophages are associated with the anti-inflammatory mechanisms. Reprogramming macrophages to switch their phenotypes could provide a new therapeutic strategy, and targeting the M1/M2 macrop

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Zhang, Linping, Yanting Zhu, Xiaoming Wang, Zhenjiang Li, and Qianlan Dong. "Immuno-Nanoparticles Developed Using Dexamethasone and Captopril Co-Loaded PLGA Improve Glomerulonephritis Through Modulating Macrophage Polarization." Journal of Biomedical Nanotechnology 19, no. 10 (2023): 1685–96. http://dx.doi.org/10.1166/jbn.2023.3615.

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The purpose of this study was to prepare liposome-coated poly(lactic-co-glycolic acid) co-loaded with dexamethasone (DXMS, D) and captopril (CAP, C) loading with PLGA nanoparticles (P) and modified polyethylene glycol and integrin α8 antibody on the surface of nanoparticles to obtain double-drug-loaded core–shell immunoliposome composite nanoparticles (DCPI), and then studied the loading Kidney targeting, anti-inflammatory effects and effects on macrophage differentiation of drug nanoparticles. In vitro cell experiments showed that DCPI could reduce the secretion of M2 macrophage-specific cyto

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Liu, Can, Wenyi Wang, Kaixin Zhang, et al. "Protective Effects of Polydatin from Grapes and Reynoutria japonica Houtt. on Damaged Macrophages Treated with Acetaminophen." Nutrients 14, no. 10 (2022): 2077. http://dx.doi.org/10.3390/nu14102077.

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The unregulated use of acetaminophen (APAP), an antipyretic and analgesic drug, harms hepatocytes and kidney cells, leading to liver failure and acute kidney injury. Herein, we investigate whether APAP damages macrophages in the immune system by observing its effects on macrophage proliferation and apoptosis. Using proteomics, we analyzed the effects of APAP on macrophage protein expression profiles and evaluated whether polydatin, the active ingredient in grapes and wine, can repair the damaged cells. The results showed that APAP alters the morphology and physiological processes of macrophage

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Misra, Uma K., Govind Gawdi, and Salvatore V. Pizzo. "Cyclosporin A Inhibits Inositol 1,4,5-Trisphosphate Binding to Its Receptors and Release of Calcium from Intracellular Stores in Peritoneal Macrophages." Journal of Immunology 161, no. 11 (1998): 6122–27. http://dx.doi.org/10.4049/jimmunol.161.11.6122.

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Abstract We have studied the effects of the immunosuppressive drug cyclosporin A (CsA) on the generation of inositol 1,4,5-trisphosphate (IP3) and intracellular Ca2+ levels elicited upon ligation of murine macrophage receptors for α2-macroglobulin, bradykinin, epidermal growth factor, and platelet-derived growth factor. Preincubation of cells with CsA (500 ng/ml), either alone or with the various ligands, did not inhibit the synthesis of IP3. However, we observed 70–80% inhibition of the binding of [3H]IP3 to IP3 receptors on macrophage membranes isolated from CsA-treated macrophages. Preincub

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Taghizadeh, Eskandar, Forough Taheri, Pedram G. Renani, Željko Reiner, Jamshid G. Navashenaq, and Amirhossein Sahebkar. "Macrophage: A Key Therapeutic Target in Atherosclerosis?" Current Pharmaceutical Design 25, no. 29 (2019): 3165–74. http://dx.doi.org/10.2174/1381612825666190830153056.

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Background: Atherosclerosis is a chronic inflammatory disease and a leading cause of coronary artery disease, peripheral vascular disease and stroke. Lipid-laden macrophages are derived from circulating monocytes and form fatty streaks as the first step of atherogenesis. Methods: An electronic search in major databases was performed to review new therapeutic opportunities for influencing the inflammatory component of atherosclerosis based on monocytes/macrophages targeting. Results: In the past two decades, macrophages have been recognized as the main players in atherogenesis but also in its t

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Boltnarova, Barbora, Jana Kubackova, Josef Skoda, et al. "PLGA Based Nanospheres as a Potent Macrophage-Specific Drug Delivery System." Nanomaterials 11, no. 3 (2021): 749. http://dx.doi.org/10.3390/nano11030749.

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Macrophages possess an innate ability to scavenge heterogenous objects from the systemic circulation and to regulate inflammatory diseases in various organs via cytokine production. That makes them attractive targets for nanomedicine-based therapeutic approaches to inflammatory diseases. In the present study, we have prepared several different poly(lactic-co-glycolic acid) (PLGA) polymer nanospheres for macrophage-targeted drug delivery using both nanoprecipitation and emulsification solvent evaporation methods. Two experimental linear PLGA polymers with relatively low molar weight, one experi

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Taciak, Bartłomiej, Maciej Białasek, Malgorzata Kubiak, et al. "Abstract 1783: Harnessing macrophage-drug conjugates for allogeneic cell-based therapy of solid tumors." Cancer Research 85, no. 8_Supplement_1 (2025): 1783. https://doi.org/10.1158/1538-7445.am2025-1783.

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Abstract The treatment of solid tumors remains a significant challenge, necessitating the ongoing development of innovative therapeutic strategies. Tumor-infiltrating macrophages play a crucial role in the tumor microenvironment, making them an attractive target for drug delivery systems. Here, we introduce the Macrophage-Drug Conjugate (MDC) platform, a pioneering approach that leverages macrophages as delivery vehicles for ferritin-drug complexes. We demonstrate that macrophages actively internalize human heavy chain ferritin (HFt) via macrophage scavenger receptor 1 (MSR1) in vitro. These d

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Karimipour-Saryazdi, Amir, Mohammad Mahdi Jafari, Roya Omidi, Fatemeh Ghaffarifar, and Seyyed Hojjat Sadeghi. "Anti-leishmania Effect of Magnesium Oxide Nanoparticles on Leishmania tropica/infantum and Leishmania-Infected Macrophages." International Journal of Enteric Pathogens 10, no. 4 (2022): 144–54. http://dx.doi.org/10.34172/ijep.2022.5546.

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Background: Leishmania is an intracellular protozoan parasite that enters and reproduces in macrophage cells. Macrophages are important immune cells that phagocyte many pathogens such as bacteria, fungi, and parasites such as Leishmania spp. but are incapable of killing this parasite, living in the phagosomes of infected macrophages, multiplying, and resulting in the divesting of infected macrophages and the appearance of Leishmania lesions. Many of the present drugs for Leishmania treatment have side effects, or parasites have resistance to some of these drugs. Therefore, there is a need for

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Boltnarova, Barbora, Anna Durinova, Lenka Jandova, et al. "Dexamethasone Acetate-Loaded PLGA NanospheresTargeting Liver Macrophages." Macromolecular Bioscience 24, no. 12 (2024): 2400411. https://doi.org/10.1002/mabi.202400411.

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Glucocorticoids are potent anti-inflammatory drugs, although their use is associated with severe side effects. Loading glucocorticoids into suitable nanocarriers can significantly reduce these undesirable effects. Macrophages play a crucial role in inflammation, making them strategic targets for glucocorticoid-loaded nanocarriers. The main objective of this study is to develop a glucocorticoid-loaded PLGA nanocarrier specifically targeting liver macrophages, thereby enabling the localized release of glucocorticoids at the site of inflammation. Dexamethasone acetate (DA)-loaded PLGA nanospheres

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Harada, Ayaka, Hiroyasu Tsutsuki, Tianli Zhang, Kinnosuke Yahiro, Tomohiro Sawa, and Takuro Niidome. "Controlled Delivery of an Anti-Inflammatory Toxin to Macrophages by Mutagenesis and Nanoparticle Modification." Nanomaterials 12, no. 13 (2022): 2161. http://dx.doi.org/10.3390/nano12132161.

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Advances in drug delivery systems (DDSs) have enabled the specific delivery of drugs to target cells. Subtilase cytotoxin (SubAB) produced by certain enterohemorrhagic Escherichia coli strains induces endoplasmic reticulum (ER) stress and suppresses nitric oxide generation in macrophages. We previously reported that modification of SubAB with poly(D,L-lactide-co-glycolic) acid (PLGA) nanoparticles (SubAB-PLGA NPs) increased intracellular uptake of SubAB and had an anti-inflammatory effect on macrophages. However, specific delivery of SubAB to macrophages could not be achieved because its effec

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Zhou, Xianghong, Bo Chen, Zilong Zhang, et al. "Crosstalk between Tumor-Associated Macrophages and MicroRNAs: A Key Role in Tumor Microenvironment." International Journal of Molecular Sciences 23, no. 21 (2022): 13258. http://dx.doi.org/10.3390/ijms232113258.

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As an in-depth understanding of immunotherapy continues to grow, current anticancer therapy research is increasingly focused on the tumor microenvironment (TME). MicroRNAs (miRNAs) play crucial roles in the regulation of genetic information and expression and mediate interactions between tumor cells and components in the TME, such as tumor-associated macrophages (macrophages). Macrophages are abundant in the TME, and their different polarization directions can promote or inhibit tumor growth and progression. By regulating biological behaviors, such as macrophage recruitment, infiltration, and

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Fu, Jun, Xiaowei Luo, Miaoping Lin, et al. "Marine-Fungi-Derived Gliotoxin Promotes Autophagy to Suppress Mycobacteria tuberculosis Infection in Macrophage." Marine Drugs 21, no. 12 (2023): 616. http://dx.doi.org/10.3390/md21120616.

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The Mycobacterium tuberculosis (MTB) infection causes tuberculosis (TB) and has been a long-standing public-health threat. It is urgent that we discover novel antitubercular agents to manage the increased incidence of multidrug-resistant (MDR) or extensively drug-resistant (XDR) strains of MTB and tackle the adverse effects of the first- and second-line antitubercular drugs. We previously found that gliotoxin (1), 12, 13-dihydroxy-fumitremorgin C (2), and helvolic acid (3) from the cultures of a deep-sea-derived fungus, Aspergillus sp. SCSIO Ind09F01, showed direct anti-TB effects. As macropha

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Di Paola, Alessandra, Giuseppe Palumbo, Pietro Merli, et al. "Effects of Eltrombopag on In Vitro Macrophage Polarization in Pediatric Immune Thrombocytopenia." International Journal of Molecular Sciences 22, no. 1 (2020): 97. http://dx.doi.org/10.3390/ijms22010097.

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Immune Thrombocytopenia (ITP) is an autoimmune disease characterized by autoantibodies-mediated platelet destruction, a prevalence of M1 pro-inflammatory macrophage phenotype and an elevated T helper 1 and T helper 2 lymphocytes (Th1/Th2) ratio, resulting in impairment of inflammatory profile and immune response. Macrophages are immune cells, present as pro-inflammatory classically activated macrophages (M1) or as anti-inflammatory alternatively activated macrophages (M2). They have a key role in ITP, acting both as effector cells, phagocytizing platelets, and, as antigen presenting cells, sti

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Peng, Renyi, Hao Ji, Libo Jin, et al. "Macrophage-Based Therapies for Atherosclerosis Management." Journal of Immunology Research 2020 (January 29, 2020): 1–11. http://dx.doi.org/10.1155/2020/8131754.

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Atherosclerosis (AS), a typical chronic inflammatory vascular disease, is the main pathological basis of ischemic cardio/cerebrovascular disease (CVD). Long-term administration was characterized with low efficacy and serious side effects, while the macrophages with attractive intrinsic homing target have great potential in the efficient and safe management of AS. In this review, we focused on the systematical summary of the macrophage-based therapies in AS management, including macrophage autophagy, polarization, targeted delivery, microenvironment-triggered drug release, and macrophage- or ma

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Mor, N., B. Simon, and L. Heifets. "Bacteriostatic and bactericidal activities of benzoxazinorifamycin KRM-1648 against Mycobacterium tuberculosis and Mycobacterium avium in human macrophages." Antimicrobial Agents and Chemotherapy 40, no. 6 (1996): 1482–85. http://dx.doi.org/10.1128/aac.40.6.1482.

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Inhibitory and bactericidal activities of KRM-1648 were determined against Mycobacterium tuberculosis and M. avium residing in human monocyte-derived macrophages and extracellular M. tuberculosis and M. avium. MICs and MBCs of KRM-1648 against intracellular and extracellular bacteria were substantially lower than those of rifampin. The MICs and MBCs of either drug against the intracellular bacteria were only twofold lower than or equal to the values found for extracellular bacteria. The prolonged effect of KRM-1648 found in this study is probably associated with high ratios of intracellular ac

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Rendra, Erika, Stefanie Uhlig, Isabell Moskal, Corinna Thielemann, Harald Klüter, and Karen Bieback. "Adipose Stromal Cell-Derived Secretome Attenuates Cisplatin-Induced Injury In Vitro Surpassing the Intricate Interplay between Proximal Tubular Epithelial Cells and Macrophages." Cells 13, no. 2 (2024): 121. http://dx.doi.org/10.3390/cells13020121.

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(1) Background: The chemotherapeutic drug cisplatin exerts toxic side effects causing acute kidney injury. Mesenchymal stromal cells can ameliorate cisplatin-induced kidney injury. We hypothesize that the MSC secretome orchestrates the vicious cycle of injury and inflammation by acting on proximal tubule epithelial cells (PTECs) and macrophages individually, but further by counteracting their cellular crosstalk. (2) Methods: Conditioned medium (CM) from adipose stromal cells was used, first assessing its effect on cisplatin injury in PTECs. Second, the effects of cisplatin and the CM on macrop

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Jeong, Seungjin, Mi-Bo Kim, Suhyeon Baek, et al. "Suppression of Pro-Inflammatory M1 Polarization of LPS-Stimulated RAW 264.7 Macrophage Cells by Fucoxanthin-Rich Sargassum hemiphyllum." Marine Drugs 21, no. 10 (2023): 533. http://dx.doi.org/10.3390/md21100533.

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Macrophages play an important role in managing the onset and progression of chronic inflammatory diseases. The primary objective of this study is to explore the antioxidant potential and anti-inflammatory properties of Sargassum hemiphyllum ethanol extract (SHE) and its fraction. SHE and its five constituent fractions were assessed for overall antioxidant capabilities and inhibitory effects on LPS-induced inflammation by modulating macrophages polarization in both RAW 264.7 macrophages and bone-marrow-derived macrophages (BMDM). Among the organic solvent fractions of SHE, the ethyl acetate fra

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Peltier, N. W., J. Uhl, L. M. Brophy, C. R. Daniels, V. L. Steel, and E. M. Merisko. "The effects of poloxamer coatings on the phagocytic uptake of polystyrene nanoparticles by peritoneal macrophages." Proceedings, annual meeting, Electron Microscopy Society of America 48, no. 3 (1990): 848–49. http://dx.doi.org/10.1017/s0424820100161801.

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The activity of the mononuclear phagocytic system (MPS) is a primary impediment for site-specific delivery of parenterally administered drugs. Following intravenous administration of nanoparticulate drug earners, the carrier system is recognized as foreign and is rapidly removed from the blood primarily by the mononuclear phagocytes of the liver and spleen. The efficiency of this process renders delivery of particulate drug carrier complexes to other sites of action difficult. Recent studies have demonstrated the extent of sequestration of colloidal particles by the MPS can be effectively modu

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Jeon, Hyungsik, Soyeon Oh, Eunjoo Kum, Sooyeong Seo, Youngjun Park, and Giok Kim. "Immunomodulatory Effects of an Aqueous Extract of Black Radish on Mouse Macrophages via the TLR2/4-Mediated Signaling Pathway." Pharmaceuticals 15, no. 11 (2022): 1376. http://dx.doi.org/10.3390/ph15111376.

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Here, we determined the immunostimulatory effects of black radish (Raphanus sativus ver niger) hot water extract (BRHE) on a mouse macrophage cell line (RAW 264.7) and mouse peritoneal macrophages. We found that BRHE treatment increased cell proliferation, phagocytic activity, nitric oxide (NO) levels, cytokine production, and reactive oxygen species synthesis. Moreover, BRHE increased the expression of the following immunomodulators in RAW 264.7 cells and peritoneal macrophages: pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α), iNOS, and COX-2. BRHE treatment significantly up-regulated the

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Olchowy, Timothy W. J., David F. Dean, and Philip N. Bochsler. "Attempt to pharmacologically modulate procoagulant activity of lipopolysaccharide-stimulated adherent bovine alveolar macrophages." American Journal of Veterinary Research 57, no. 5 (1996): 659–63. http://dx.doi.org/10.2460/ajvr.1996.57.05.659.

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Abstract Objective To investigate the effects of anti-inflammatory drugs on lipopolysaccharide-induced procoagulant activity of bovine alveolar macrophages. Design Procoagulant activity was induced in bovine alveolar macrophages from 4 healthy Holstein calves aged 6 to 16 weeks by incubation with lipopolysaccharide. 3 anti-inflammatory drugs were used at 4 concentrations and 3 times to pretreat the alveolar macrophages. Results were analyzed to determine whether drug, concentration, or exposure period had a significant (P> 0.05) effect. Procedure Bovine alveolar macrophages, harvested by vo

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Yang, Jing, Yuhuan Zheng, Zhen Cai, et al. "Myeloma and the Microenvironment: Macrophages Are a Protector of Myeloma Cells Apoptosis Induced by Chemotherapy Drugs." Blood 114, no. 22 (2009): 4804. http://dx.doi.org/10.1182/blood.v114.22.4804.4804.

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Abstract Abstract 4804 Multiple myeloma is a B-cell malignancy characterized by the proliferation of plasma cells in the bone marrow. It is the second most common hematological malignancy and is still largely incurable. One of the major problems is that myeloma cells develop drug resistance upon interaction with bone marrow stromal cells. To better understand the importance of different stromal cell components in the bone marrow microenvironment, we examined the effects of macrophages on myeloma cell survival and myeloma cell response to chemotherapy. We report here that macrophages, in partic

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Linnenberger, Rebecca, Jessica Hoppstädter, Selina Wrublewsky, Emmanuel Ampofo, and Alexandra K. Kiemer. "Statins and Bempedoic Acid: Different Actions of Cholesterol Inhibitors on Macrophage Activation." International Journal of Molecular Sciences 22, no. 22 (2021): 12480. http://dx.doi.org/10.3390/ijms222212480.

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Statins represent the most prescribed class of drugs for the treatment of hypercholesterolemia. Effects that go beyond lipid-lowering actions have been suggested to contribute to their beneficial pharmacological properties. Whether and how statins act on macrophages has been a matter of debate. In the present study, we aimed at characterizing the impact of statins on macrophage polarization and comparing these to the effects of bempedoic acid, a recently registered drug for the treatment of hypercholesterolemia, which has been suggested to have a similar beneficial profile but fewer side effec

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Coya, Juan Manuel, Matteis Laura De, Alexandre Giraud-Gatineau, et al. "Tri-mannose grafting of chitosan nanocarriers remodels the macrophage response to bacterial infection." Journal of Nanobiotechnology 17, no. 1 (2019): 15. https://doi.org/10.1186/s12951-018-0439-x.

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<strong>Background: </strong>Infectious diseases are still a leading cause of death and, with the emergence of drug resistance, pose a great threat to human health. New drugs and strategies are thus urgently needed to improve treatment efficacy and limit drug-associated side effects. Nanotechnology-based drug delivery systems are promising approaches, offering hope in the fight against drug resistant bacteria. However, how nanocarriers influence the response of innate immune cells to bacterial infection is mostly unknown.<strong>Results: </strong>Here, we used <i>Mycobacterium tuberculosis</i>

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Durr, Marie, Manasa Suresh, Bryan Weselman, et al. "Abstract 7277: Development of a macrophage-based screening pipeline to evaluate the immunomodulatory effects of small molecule inhibitors." Cancer Research 85, no. 8_Supplement_1 (2025): 7277. https://doi.org/10.1158/1538-7445.am2025-7277.

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Abstract Introduction: Immunotherapies targeting adaptive immunity have shown promising results in solid tumors; however, many patients are either unresponsive or develop resistance. Emerging interest in innate immunity has driven novel strategies to target myeloid cells, including tumor-associated macrophages (TAMs). TAMs primarily have an anti-inflammatory, pro-tumoral M2-like phenotype secreting growth and angiogenic factors to promote an immunosuppressive tumor microenvironment (TME). Modulating the TAMs towards a more proinflammatory M1-like elicits anti-tumor responses with enhanced anti

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Aranaga, Carlos, Ruben Varela, Aura Falco, et al. "In Vitro Activity of the Triazinyl Diazepine Compound FTSD2 Against Drug-Resistant Mycobacterium tuberculosis Strains." Pharmaceuticals 18, no. 3 (2025): 360. https://doi.org/10.3390/ph18030360.

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Background/Objectives: Compounds derived from pyrimido-diazepine have shown selective inhibition of the susceptible Mycobacterium tuberculosis strain H37Rv. However, there is a need for studies that evaluate the activity of these compounds against multidrug-resistant strains and clinical isolates. This study aims to evaluate the antitubercular potential of FTSD2 against drug-resistant strains of M. tuberculosis. Methods: The compound 4-(2,4-diamino-8-(4-methoxyphenyl)-8,9-dihydro-7H-pyrimido[4,5-b][1,4]diazepin-6-yl)-N-(2-(4-(dimethylamino)-6-(4-fluorophenyl)amino-1,3,5-triazin-2-yl)amino)ethy

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Białasek, Maciej, Miaomiao Sun, Bartłomiej Taciak, et al. "Abstract 3197: Macrophage-ferritin-drug conjugates: a novel approach to overcome glioblastoma drug resistance and induce long-term tumor immunity." Cancer Research 85, no. 8_Supplement_1 (2025): 3197. https://doi.org/10.1158/1538-7445.am2025-3197.

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Abstract Glioblastoma (GBM) remains a major clinical challenge due to its resistance to conventional therapies and immunosuppressive tumor microenvironment. To address these challenges, we developed Macrophage-Ferritin-Drug Conjugates (MDCs), leveraging the unique ability of macrophages to infiltrate gliomas and transfer therapeutic ferritin-drug complexes directly to cancer cells. In orthotopic glioma models (GL-261 and CT-2A), MDC-735, consisting of macrophages loaded with ferritin conjugated to inhibitor of tubulin polymerization, demonstrated significant tumor reduction and improved surviv

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Bialasek, Maciej, Miaomiao Sun, Ilona Marszalek, et al. "Abstract A037: Macrophage-Ferritin-Drug Conjugates: A Novel Approach to Overcome Glioblastoma Drug Resistance and Induce Long-Term Tumor Immunity." Cancer Immunology Research 13, no. 2_Supplement (2025): A037. https://doi.org/10.1158/2326-6074.io2025-a037.

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Abstract Glioblastoma (GBM) remains a major clinical challenge due to its resistance to conventional therapies and immunosuppressive tumor microenvironment. To address these challenges, we developed Macrophage-Ferritin-Drug Conjugates (MDCs), leveraging the unique ability of macrophages to infiltrate gliomas and transfer therapeutic ferritin-drug complexes directly to cancer cells. In orthotopic glioma models (GL-261 and CT-2A), MDC-735, consisting of macrophages loaded with ferritin conjugated to inhibitor of tubulin polymerization, demonstrated significant tumor reduction and improved surviv

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Liu, Bohao, Cong Ding, Wenbin Tang, et al. "Hepatic ROS Mediated Macrophage Activation Is Responsible for Irinotecan Induced Liver Injury." Cells 11, no. 23 (2022): 3791. http://dx.doi.org/10.3390/cells11233791.

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Irinotecan is the first line chemotherapy drug used for treatment of metastatic colorectal cancer worldwide. There is increasing evidence suggesting that liver damage, including steatosis and steatohepatitis, can be caused during the treatment involving irinotecan. However, molecular mechanisms by which irinotecan-induced liver injury remain elusive. In this study, we found that irinotecan treatment caused significant elevation of ALT, inflammation, and fat accumulation in the liver, which are associated with hepatic macrophage activation. Depletion of macrophages by clodronate liposome improv

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Salathia, Saniya, Maria Rosa Gigliobianco, Cristina Casadidio, Piera Di Martino, and Roberta Censi. "Hyaluronic Acid-Based Nanosystems for CD44 Mediated Anti-Inflammatory and Antinociceptive Activity." International Journal of Molecular Sciences 24, no. 8 (2023): 7286. http://dx.doi.org/10.3390/ijms24087286.

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The nervous and immune systems go hand in hand in causing inflammation and pain. However, the two are not mutually exclusive. While some diseases cause inflammation, others are caused by it. Macrophages play an important role in modulating inflammation to trigger neuropathic pain. Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan that has a well-known ability to bind with the cluster of differentiation 44 (CD44) receptor on classically activated M1 macrophages. Resolving inflammation by varying the molecular weight of HA is a debated concept. HA-based drug delivery nanosystems su

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Larsen, Søren T., Emilie Da Silva, Jitka S. Hansen, Alexander C. Ø. Jensen, Ismo K. Koponen, and Jorid B. Sørli. "Acute Inhalation Toxicity After Inhalation of ZnO Nanoparticles: Lung Surfactant Function Inhibition In Vitro Correlates With Reduced Tidal Volume in Mice." International Journal of Toxicology 39, no. 4 (2020): 321–27. http://dx.doi.org/10.1177/1091581820933146.

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People can be exposed to zinc oxide (ZnO) by inhalation of consumer products or during industrial processes. Zinc oxide nanoparticle (NP) exposure can induce acute inhalation toxicity. The toxicological mechanisms underlying the acute effects on the lungs have long focused on the phagolysosomal dissolution of ZnO NPs in macrophages followed by the release of free Zn2+ ions. However, we postulate an alternative mechanism based on the direct interaction of ZnO NPs with the lung surfactant (LS) layer covering the inside of the alveoli. Therefore, we tested the effect of ZnO NPs and Zn2+ ions on t

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Kalenichenko, Daria, Irina Kriukova, Alexander Karaulov, Igor Nabiev, and Alyona Sukhanova. "Cytotoxic Effects of Doxorubicin on Cancer Cells and Macrophages Depend Differently on the Microcarrier Structure." Pharmaceutics 16, no. 6 (2024): 785. http://dx.doi.org/10.3390/pharmaceutics16060785.

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Microparticles are versatile carriers for controlled drug delivery in personalized, targeted therapy of various diseases, including cancer. The tumor microenvironment contains different infiltrating cells, including immune cells, which can affect the efficacy of antitumor drugs. Here, prototype microparticle-based systems for the delivery of the antitumor drug doxorubicin (DOX) were developed, and their cytotoxic effects on human epidermoid carcinoma cells and macrophages derived from human leukemia monocytic cells were compared in vitro. DOX-containing calcium carbonate microparticles with or

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Abuarqoub, Duaa, Nouf N. Mahmoud, Rand Zaza, Rana Abu-Dahab, Enam A. Khalil, and Dima A. Sabbah. "The In Vitro Immunomodulatory Effects of Gold Nanocomplex on THP-1-Derived Macrophages." Journal of Immunology Research 2022 (February 10, 2022): 1–8. http://dx.doi.org/10.1155/2022/6031776.

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Introduction. This study is aimed at investigating the immunological response after treating THP-1 cells with gold nanorods conjugated with a phosphatidylinositol 3-kinase (PI3Kα) inhibitor. Methodology. Gold nanorods were synthesized and functionalized with cholesterol-PEG-SH moiety, and the treatment groups were as follows: nanocomplex (a drug-conjugated gold nanorods), free drug (phosphatidylinositol 3-kinase (PI3Kα) inhibitor), and GNR (the nanocarrier; cholesterol-coated gold nanorods). THP-1 cells were differentiated into macrophages and characterized by measuring the expression of macro

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Xu, Jinglei, Yihao Che, Xinyue Liu, et al. "The Regulating Effect of CII-3 and Its Active Components from Periplaneta americana on M1/M2 Macrophage Polarization." Molecules 27, no. 14 (2022): 4416. http://dx.doi.org/10.3390/molecules27144416.

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CII-3 is the effective part of Periplaneta americana for application in oncotherapy. This study investigated its main chemical components for macrophage polarization regulation activity. Compounds were separated and purified, and their structures were elucidated based on NMR and HR-ESI-MS analyses. After inducing the M1 and M2 phenotype macrophages, CII-3 and testing components were added and co-incubated to evaluate their effects on the relevant markers of macrophages. Then, gradient concentrations of CII-3 and active monomers were further investigated for their effects on M2 macrophages. The

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Cao, Wen, Jing Chen, Enfan Zhang, and Zhen Cai. "E3 Ubiquitin Ligase TRIM21 Enhances Macrophage-Mediated Bortezomib Resistance By Inducing M2 Polarization in Multiple Myeloma." Blood 144, Supplement 1 (2024): 6829. https://doi.org/10.1182/blood-2024-209627.

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Multiple myeloma is a hematologic malignancies characterized by clonal plasma cell abnormalities in the bone marrow. Although new drugs such as proteasome inhibitors(PIs), immunomodulators(IMiD) and autologous hematopoietic stem cell transplantation have significantly prolonged the survival time of MM patients, MM is still incurable, the majority of MM patients relapsed or refractory due to disease progression. It has been shown that the bone marrow microenvironment plays an important role in the proliferation, growth and drug resistance of MM cells. As the major component of the MM bone marro

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Giorgio, Selma, and Pedro Henrique Gallo-Francisco. "A CELL-CULTURING SYSTEM FOR THE STUDY OF INTERACTION BETWEEN MACROPHAGES INFECTED WITH Leishmania amazonensis." Revista de Patologia Tropical / Journal of Tropical Pathology 48, no. 2 (2019): 99–108. http://dx.doi.org/10.5216/rpt.v48i2.58004.

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The cell culture insert system is a culturing system for the study of contact-independent cellular communication. Leishmaniasis is a neglect tropical disease with no vaccines and the availabledrugs present toxic side effects. Studies on Leishmania interaction with host macrophages aim to develop strategies for parasite control and drug development. The purpose of this study was to evaluate the effects of interaction between non-infected and L. amazonensis-infected human macrophages, by using the cell culture system. The results showed that the infection index was reduced by 56.2% as compared t

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Park, Jihyeon, Jisun Oh, Sang-Hyun Min, Ji Hoon Yu, Jong-Sup Bae та Hui-Jeon Jeon. "Targeting RARγ Decreases Immunosuppressive Macrophage Polarization and Reduces Tumor Growth". Molecules 30, № 15 (2025): 3099. https://doi.org/10.3390/molecules30153099.

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Tumor-associated macrophages (TAMs) play a critical role in the tumor microenvironment (TME), interacting with cancer cells and other components to promote tumor growth. Given the influence of TAMs on tumor progression and resistance to therapy, regulating the activity of these macrophages is crucial for improving cancer treatment outcomes. TAMs often exhibit immunosuppressive phenotypes (commonly referred to as M2-like macrophages), which suppress immune responses and contribute to drug resistance. Therefore, inhibiting immunosuppressive polarization offers a promising strategy to impede tumo

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Ni, Mingmin, Kaitao Wang, Yongqing Tian, Lifu Zhou, Xiaohua Yang, and Mingmin Ni. "Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies." Journal of Biological Regulators and Homeostatic Agents 39, no. 2 (2025): 3315. https://doi.org/10.54517/jbrha3315.

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<p><span lang="EN-US">Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adso

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Horgen, Lionel, Arnaud Jerome, and Nalin Rastogi. "Pulsed-Exposure and Postantibiotic Leukocyte Enhancement Effects of Amikacin, Clarithromycin, Clofazimine, and Rifampin against Intracellular Mycobacterium avium." Antimicrobial Agents and Chemotherapy 42, no. 11 (1998): 3006–8. http://dx.doi.org/10.1128/aac.42.11.3006.

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ABSTRACT We investigated the postantibiotic effects (PAEs) of four agents against Mycobacterium avium in a human macrophage model under two different experimental conditions. For postantibiotic leukocyte enhancement (PALE), bacteria were exposed to antibiotics prior to their phagocytosis, whereas for pulsed exposure (PE), antibiotics were added after phagocytosis. In both cases, the drugs were used at their peak concentrations in serum (C max) for 2 h. The results showed two different patterns: one for the drug for which results under PE and PALE test conditions did not significantly differ (a

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Gonçalves, Jenifer Pendiuk, Maria Luiza Ferreira dos Santos, Gustavo Rodrigues Rossi, Viviana Stephanie Costa Gagosian, and Carolina Camargo de Oliveira. "Differential effects of Zincum metallicum on cell models." Homeopathy 106, no. 03 (2017): 171–80. http://dx.doi.org/10.1016/j.homp.2017.02.004.

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Introduction: Zinc is an essential trace element necessary for life. Traditional and complementary medicines use zinc-based formulations to treat different classes of diseases. Basic research on homeopathic preparations of zinc are rare and there are a few published clinical cases describing its effects on patients. The use of cell-based models in drug screening is a reliable source of evidence.Methods: We sought to investigate experimental end-points using cell-based models to determine the effects of dilutions of Zincum metallicum prepared according to the Brazilian Homeopathic Pharmacopoeia

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Palay, D. A., C. W. Cluff, P. A. Wentworth, and H. K. Ziegler. "Cyclosporine inhibits macrophage-mediated antigen presentation." Journal of Immunology 136, no. 12 (1986): 4348–53. http://dx.doi.org/10.4049/jimmunol.136.12.4348.

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Abstract The influence of cyclosporine on antigen-specific, macrophage-dependent T cell activation was analyzed in vitro. Murine T cell activation by antigens derived from Listeria monocytogenes was monitored by the production of interleukin 2. Pretreatment (2 hr, 37 degrees C) of macrophages with cyclosporine resulted in a cell population with a markedly diminished capacity to support the activation of T lymphocytes. When cyclosporine-pretreated macrophages were added to cultures of untreated T cells and antigen, the dose of cyclosporine that produced 50% inhibition (ID50) was 1.5 micrograms/

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Yu, Jinghan, Yingying Meng, Zhiyang Wen, et al. "Investigation of Factors Influencing the Effectiveness of Deformable Nanovesicles for Insulin Nebulization Inhalation." Pharmaceutics 16, no. 7 (2024): 879. http://dx.doi.org/10.3390/pharmaceutics16070879.

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Nebulized inhalation offers a noninvasive method for delivering drugs to treat both local respiratory and systemic diseases. In this study, insulin was used as a model drug to design a series of deformable nanovesicles (DNVs) with key quality attributes, including particle size, deformability, and drug load capacity. We investigated the effects of these properties on aerosol generation, macrophage phagocytosis, and bloodstream penetration. The results showed that deformability improved nebulization performance and reduced macrophage phagocytosis, benefiting local and systemic delivery. However

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Nassif, Rana M., Elias Chalhoub, Pia Chedid, et al. "Metformin Inhibits ROS Production by Human M2 Macrophages via the Activation of AMPK." Biomedicines 10, no. 2 (2022): 319. http://dx.doi.org/10.3390/biomedicines10020319.

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Metformin (1,1-dimethylbiguanide hydrochloride) is the most commonly used drug to treat type II diabetic patients. It is believed that this drug has several other beneficial effects, such as anti-inflammatory and anticancer effects. Here, we wanted to evaluate the effect of metformin on the production of reactive oxygen species (ROS) by human macrophages. Macrophages are generated in vivo from circulating monocytes depending on the local tissue environment. In vitro proinflammatory macrophages (M1) and anti-inflammatory macrophages (M2) can be generated by culturing monocytes in the presence o

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Kang, Jin-Kyu, Hyun-Kyu Kang, and Chang-Gu Hyun. "Anti-Inflammatory Effects of Spiramycin in LPS-Activated RAW 264.7 Macrophages." Molecules 27, no. 10 (2022): 3202. http://dx.doi.org/10.3390/molecules27103202.

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Drug repurposing is a simple concept with a long history, and is a paradigm shift that can significantly reduce the costs and accelerate the process of bringing a new small-molecule drug into clinical practice. We attempted to uncover a new application of spiramycin, an old medication that was classically prescribed for toxoplasmosis and various other soft-tissue infections; specifically, we initiated a study on the anti-inflammatory capacity of spiramycin. For this purpose, we used murine macrophage RAW 264.7 as a model for this experiment and investigated the anti-inflammatory effects of spi

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Deng, Jun-Jin, Zong-Qiu Li, Ze-Quan Mo, et al. "Immunomodulatory Effects of N-Acetyl Chitooligosaccharides on RAW264.7 Macrophages." Marine Drugs 18, no. 8 (2020): 421. http://dx.doi.org/10.3390/md18080421.

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The ongoing development of new production methods may lead to the commercialization of N-acetyl chitooligosaccharides (NACOS), such as chitosan oligosaccharides (COS). The bioactivity of NACOS, although not well detailed, differs from that of COS, as they have more acetyl groups than COS. We used two enzymatically produced NACOS with different molecular compositions and six NACOS (NACOS1–6) with a single degree of polymerization to verify their immunomodulatory effects on the RAW264.7 macrophage cell line. We aimed to identify any differences between COS and various NACOS with a single degree

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Claro-Cala, Carmen M., Elena Grao-Cruces, Rocio Toscano, Maria C. Millan-Linares, Sergio Montserrat-de la Paz, and Maria E. Martin. "Acyclic Diterpene Phytol from Hemp Seed Oil (Cannabis sativa L.) Exerts Anti-Inflammatory Activity on Primary Human Monocytes-Macrophages." Foods 11, no. 15 (2022): 2366. http://dx.doi.org/10.3390/foods11152366.

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Seeds from non-drug varieties of hemp (Cannabis sativa L.) have been used for traditional medicine, food, and fiber production. Our study shows that phytol obtained from hemp seed oil (HSO) exerts anti-inflammatory activity in human monocyte-macrophages. Fresh human monocytes and human macrophages derived from circulating monocytes were used to evaluate both plasticity and anti-inflammatory effects of phytol from HSO at 10–100 mM using FACS analysis, ELISA, and RT-qPCR methods. The quantitative study of the acyclic alcohol fraction isolated from HSO shows that phytol is the most abundant compo

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