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Dissertations / Theses on the topic 'Magerie'

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Published: 4 June 2021
Last updated: 4 May 2024

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1

Madec, Sylvain. "Reconnaissance des lettres : contributions expérimentales en potentiels évoqués et imagerie par résonnance magnétique fonctionnelle." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4748.

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Cette thèse porte sur les processus de perception visuelle impliqués dans la reconnaissance des lettres. L’Étude 1 vise à déterminer la fenêtre temporelle à partir de laquelle les lettres sont discriminées. Nos résultats démontrent, en établissant un lien entre potentiels évoqués (PEs) et indices comportementaux, des effets apparaissant vers 100 ms et 220 ms au niveau d’électrodes occipitales droites, que nous lions à des traitements visuels, et un effet apparaissant aux alentours de 170 ms au niveau d’électrodes fronto-centrales, que nous lions à la possible récupération du nom des lettres. L’Étude 2 vise à déterminer jusqu’à quand, lors du processus de reconnaissance des lettres, trouve-t-on des influences de traitements de nature visuelle? Nous comparons les PEs de lettres nominalement similaires, mais visuellement dissimilaires (variant selon la casse), et nos résultats indiquent des influences visuelles toujours à l’œuvre aux alentours de 300 ms. L’Étude 3 vise à mettre en évidence les aires cérébrales impliquées dans la récupération du nom des lettres, révélées en imagerie par résonance magnétique fonctionnelle (IRMf), mais également les effets induits par cette récupération sur les PEs. Nous utilisons un paradigme d’apprentissage de symboles inconnus, durant lequel nous induisons une gradation dans la capacité des participants à pouvoir récupérer le nom des symboles. Cette gradation est alors utilisée comme marqueur de récupération du nom des symboles au niveau des PEs et des images fonctionnelles. Nous démontrons une covariation avec la gradation induite aux alentours de 200 ms sur les PEs, et au niveau du gyrus fusiforme et d’aires temporales gauches en IRMf
The aim of this thesis is to investigate visual perception processes involved in recognizing letters. Study 1 aims at determining the time window during which letters are discriminated. Our results linking event-related potentials (ERPs) and behavioral measures, indicate effects occurring around 100 ms and 220 ms on right occipital electrodes as reflecting visual processing, while we assume that an effect occurring around 170 ms on fronto-central electrodes might be functionally linked to the retrieval of letter names.Study 2 aims at determining until when, along the process of letter recognition, influences of visual processing are observed. We compare ERPs associated with nominally similar but visually dissimilar letters (by varying the case of presentation), and our results indicate that visual influences are still active until around 300 ms. Study 3 aims at highlighting both the brain areas involved in the retrieval of letter names, as revealed by functional magnetic resonance imaging (fMRI), and the effects induced by this retrieval on ERPs. We use a learning paradigm of unknown visual symbols, in which we induce a gradation in the ability of participants to retrieve the name of these symbols. The gradation is used as a marker of the retrieval of the symbols’ names, both on ERPs and fMRI. We demonstrate that the induced gradation co-varies with ERPs at around 200 ms, and with fMRI signals on left fusiform gyrus and left temporal areas
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2

Chatelée, Vincent. "Développement d'un système d'imagerie microonde multistatique ultra large bande : application à la détection d'objets en régime temporel et fréquentiel." Phd thesis, Université de Nice Sophia-Antipolis, 2006. http://tel.archives-ouvertes.fr/tel-00696606.

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Une des techniques pour obtenir des images de structures hétérogènes ou d'objets enfouis dans un milieu (sol, murs, ...) repose sur la mesure du champ électromagnétique diffracté par les inhomo-généités lorsqu'elles sont soumises à une illumination incidente. Cela nécessite la mise en oeuvre d'un système d'acquisition microonde doté d'un réseau de capteurs linéaire ou plan. Ses critères de conception sont dictés par les algorithmes d'imagerie qui nécessitent le plus souvent des données multifréquences acquises sur une large fenêtre d'observation. Ce travail de thèse repose sur la caractérisation, le calibrage et la validation expérimentale d'un prototype d'imageur multistatique ultra large bande. Un descriptif des systèmes actuels d'imagerie microonde a permis tout d'abord de valider les critères retenus pour le cahier des charges initial et de décrire les considérations associées à un problème de détection subsurface. Le Système d'Imagerie Microonde à Impulsions Synthétiques (SIMIS), dévelopé au LEAT, est caractérisé par ses performances théoriques, et une attention particulière a porté sur l'optimisation de la dynamique de détection. Afin de corriger les erreurs systématiques, le calibrage du radar est accompli sur chaque module successivement, puis, plusieurs études portant sur les erreurs de dérive et les erreurs aléatoires sont proposées. Le système est ensuite utilisé en chambre anéchoïque pour la détection de cibles canoniques (un cylindre métallique et un parallélépipède diélectrique) dans une configuration 2D-TM. La détection des deux objets est confirmée par l'observation d'hyperboles de diffraction sur des images apparentées B-scan. Une modification du système est effectuée et validée afin de réduire le couplage inter-antennes au sein du réseau de transducteurs. Cela permet, le cas échéant, de détecter les cibles à partir de la seule mesure du champ total. Les premiers résultats en imagerie qualitative sont obtenus par la technique du miroir à retournement temporel. Dans le domaine fréquentiel, l'utilisation de la méthode DORT (Décomposition de l'Opérateur de Retournement Temporel) a permis également de détecter les cibles lorsque la longueur d'onde est comparable à leur dimension transverse.
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3

Riesch, Christian [Verfasser], Robert [Akademischer Betreuer] Magerle, Robert [Gutachter] Magerle, and Günter [Gutachter] Radons. "Non-equilibrium dynamics in ordered modulated phases / Christian Riesch ; Gutachter: Robert Magerle, Günter Radons ; Betreuer: Robert Magerle." Chemnitz : Universitätsbibliothek Chemnitz, 2015. http://d-nb.info/1213813395/34.

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4

Tong, Xiao. "Recalage d'image de la tomographie optique diffuse de fluorescence (fDOT) et la tomographie par émission de positons (TEP) et le développement de tomographie optique en multi-angle." Phd thesis, Université Paris Sud - Paris XI, 2012. http://tel.archives-ouvertes.fr/tel-00795178.

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Ce travail de thèse concerne le traitement d'image fDOT (fDOT pour fluorescence diffuse optical tomography) suit vers deux axes. Le recalage d'images fDOT à l'aide de l'imagerie TEP (tomographie par émission de positons) et l'amélioration des reconstructions fDOT à l'aide de miroirs pour collecter des projections complémentaires. Il est présenté en deux parties : Dans la première partie, une méthode automatique pour recaler les images de fDOT avec les images de Tomographie par Emission de Positons (TEP) développée dans le but de corréler l'ensemble des informations issues de chaque modalité. Cette méthode de recalage est basée sur une détection automatique de marqueurs fiduciaires présents dans les deux modalités. La particularité de cette méthode est l'utilisation de l'image de surface obtenue en fDOT, qui sert à identifier la position en Z des marqueurs fiduciaires dans les images optiques. Nous avons testé cette méthode sur un modèle de souris porteuses de xénogreffes de tumeurs de cellules cancéreuses MEN2A qui imitent un carcinome thyroïdien médullaire humain, après une double injection de traceur radioactif : [18F]2-fluoro-2-Deoxy-D-glucose (FDG) pour l'imagerie TEP et un traceur optique d'infrarouge fluorescent, le Sentidye. Grâce à la précision de notre méthode, nous arrivons à démontrer que le signal Sentidye est présent à la fois dans la tumeur et les vaisseaux environnants [1]. La qualité des images fDOT est dégradée selon l'axe Z du fait d'un nombre limité de projections pour la reconstruction. Dans la deuxième partie, le travail s'est orienté vers une nouvelle méthode de reconstruction d'images fDOT à partir d'un nouveau système d'acquisition multi-angulaire avec deux miroirs placés de chaque côté de l'animal. Ce travail a été mené en collaboration avec le département CS d'University College London (UCL), partenaire du projet Européen FMT-XCT. Le logiciel TOAST développé par cette équipe a été utilisé comme source pour l'algorithme de reconstruction, et modifié pour s'adapter à notre problématique. Après plusieurs essais concernant l'ajustement des paramètres du programme, nous avons appliqué cette méthode sur un fantôme réaliste des tissus biologiques et chez la souris. Les résultats montrent une amélioration de l'image reconstruite d'un fantôme semi-cylindrique et de l'image de rein chez la souris, pour lesquelles la méthode des miroirs est supérieure à la méthode classique sans miroir. Malgré tout, nous avons observé que les résultats étaient très sensibles à certains paramètres, d'où une performance de reconstruction variable d'un cas à l'autre. Les perspectives futures concernent l'optimisation des paramètres afin de généraliser l'approche multi-angle.
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5

Spitzner, Eike-Christian [Verfasser], Robert [Akademischer Betreuer] Magerle, Robert [Gutachter] Magerle, and Borczyskowski Christian [Gutachter] von. "Subsurface and MUSIC-Mode Atomic Force Microscopy / Eike-Christian Spitzner ; Gutachter: Robert Magerle, Christian von Borczyskowski ; Betreuer: Robert Magerle." Chemnitz : Universitätsbibliothek Chemnitz, 2012. http://d-nb.info/1214244254/34.

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6

Neumann, Martin [Verfasser], Robert [Akademischer Betreuer] Magerle, Robert [Gutachter] Magerle, and Borczyskowski Christian [Gutachter] von. "Time-resolved imaging of the micro-mechanical behavior of elastomeric polypropylene / Martin Neumann ; Gutachter: Robert Magerle, Christian von Borczyskowski ; Betreuer: Robert Magerle." Chemnitz : Universitätsbibliothek Chemnitz, 2015. http://d-nb.info/121381376X/34.

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7

Dehnert, Martin [Verfasser], Robert [Akademischer Betreuer] Magerle, Robert [Gutachter] Magerle, and Christoph [Gutachter] Tegenkamp. "3D-Tiefenprofile der Wechselwirkung zwischen einer AFM-Spitze und weichen polymeren Materialien / Martin Dehnert ; Gutachter: Robert Magerle, Christoph Tegenkamp ; Betreuer: Robert Magerle." Chemnitz : Technische Universität Chemnitz, 2018. http://d-nb.info/1214820549/34.

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8

Kumar, Vishant. "Fragmentation dynamics and geometrical arrangement of diatomic molecular clusters." Thesis, Normandie, 2019. http://www.theses.fr/2019NORMC245.

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L'analyse d'une expérience cinématiquement complète de collision ion-agrégats permet d'accéder à la dynamique de la dissociation des agrégats ionisés. Les cibles en phase gazeuse permettent d'étudier l'agrégat dans un environnement simple et de déterminer ses propriétés intrinsèques - en dehors de l'état condensé. De petits agrégats van der Waals de N2 et CO sont produits dans l'expansion supersonique d'un jet gazeux et irradiés par un faisceau d'ions multichargés de basse énergie produit par l'installation ARIBE/GANIL. Grâce à notre dispositif expérimental COLTRIMS (Cold Target Recoil Ion Momentum Spectroscopy), il est possible de mesurer en coïncidence les vecteurs d'impulsion 3D des fragments chargés résultant de la collision. Nous avons effectué une expérience pour étudier la dynamique de fragmentation et la géométrie des dimères et trimères de N2 et CO en utilisant un faisceau projectile Ar9+ à une énergie de 15 qkeV. Suite à une multiple capture électronique, la cible subit une dissociation en deux ou trois corps. Pour les voies à trois corps, deux processus distincts ont été identifiés dans lesquels les liaisons van der Waals et covalente se rompent simultanément ou séquentiellement. De plus, la technique d'imagerie par explosion coulombienne a été utilisée pour déterminer la structure tridimensionnelle des dimères moléculaires N2 et CO et des trimères. Nous avons observé que les molécules de N2 et CO sont orientés perpendiculairement à l'axe du dimer dans une configuration planaire (H) ou non-planaire (X) et que les trimères (N2)3 et (CO)3 présentent une géométrie en forme de triangle équilatéral
The analysis of a kinematically complete ion-cluster collision experiment provides insight in the dynamics of the ionized cluster dissociation. The gas phase targets allow to study the cluster in a simple environment and to determine their intrinsic properties for further condensed states. Small van der Waals clusters of N2 and CO are produced in the supersonic expansion of a gas jet and irradiated by a low energy highly charged ion beam produced by the ARIBE/GANIL facility. Using our experimental set-up COLTRIMS (COLd Target Recoil Ion Momentum Spectroscopy) it is made possible to measure in coincidence the 3-D momentum vectors of the charged fragments resulting from the collision. We have performed experiment to investigate the fragmentation dynamics and geometry of N2 and CO dimers and trimers using a projectile beam Ar9+ with the 15 qkeV energy. Following multiple electron capture, the target undergoes two or three body dissociation. For three body channels, two distinct processes have been identified in which the van der Waals and covalent bond breaks either simultaneously or sequentially. Additionally, the Coulomb explosion imaging technique has been used to determine the three dimensional structure of the N2 and CO molecular dimers and trimers. We found that the N2 and CO molecules sit perpendicularly to the dimer axis in a planar (H) or non-planar (X) configuration and that (N2)3 and (CO)3 trimers exhibit an equilateral triangular geometry
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9

Gerth, Stefan [Verfasser], Andreas [Akademischer Betreuer] Magerl, and Andreas [Gutachter] Magerl. "Stabilität adsorbierter Polymerschichten an Grenzflächen / Stefan Gerth ; Gutachter: Andreas Magerl ; Betreuer: Andreas Magerl." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2018. http://d-nb.info/1163806870/34.

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10

Taylor, Lisa. "Behavioural phenotype of Smith-Magenis syndrome." Thesis, University of Birmingham, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435388.

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11

Struthers, Jennifer Leigh. "Molecular screening for Smith-Magenis syndrome." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp05/MQ65646.pdf.

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12

Mathon, Julien. "Développement de nouveaux outils algorithmiques et technologiques pour l'étude du mouvement des chromosomes dans la levure S. Cerevisiae." Phd thesis, Toulouse 3, 2013. http://thesesups.ups-tlse.fr/2145/.

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Le développement des techniques d'ingénierie génétique et celles d'imagerie en microscopie de fluorescence ont ouvert la voie à l'étude du mouvement et de la structure des chromosome dans les cellules vivantes. Depuis quelques années, l'avènement de ces outils a fait naître une biophysique du noyau, dont l'objectif est de comprendre avec des modèles physiques comment s'organise le génome dans une cellule et comment il se réorganise sous l'effet de stimuli biologiques ou chimiques. L'objectif de mon travail de thèse a consisté à développer des outils permettant de mesurer précisément les déplacements des chromosomes dans les cellules vivantes, d'automatiser le processus de traitement des données et de développer des modèles quantitatifs d'analyse des données expérimentales. Dans ce travail de thèse pluridisciplinaire, nous avons à la fois optimisé une chaîne d'acquisition de microscopie de fluorescence afin de maximiser la qualité de films de levures vivantes, réalisé un algorithme de suivi de particules et de reconnaissance de forme dédiés à la levure, ainsi que des outils de traitement automatisés des trajectoires pour systématiser le processus de traitement des données. Ces méthodes ont permis de construire des modèles originaux de structure et de dynamique des chromosomes in vivo chez la levure saccharomyces cerevisiae
The development of genetic engineering and fluorescence microscopy of the yeast S. Cerevisiae has recently allowed to investigate the folding and the dynamics of chromosomes in living cells. Chromosome biophysics has now emerged as a new cross-disciplinary field of research, aiming to elucidate the function of chromosomes with physical models. Our goal was to set up original tools to monitor chromosome dynamics in living cells. This research involves the development of high speed live cell fluorescence microscopy assays, automated tracking and image analysis softwares, and analytical models of experimental measurements. We demonstrate the successfull optimization of our data acquisition process flow with novel hardware and software developments, and provide a new model of the dynamics chromosome in living Saccharomyces Cerevisiae
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13

Ullmann, Robert [Verfasser], Werner A. [Akademischer Betreuer] Goedel, and Robert [Gutachter] Magerle. "Oberflächenfunktionalisierung von Poly(dimethyl)siloxan / Robert Ullmann ; Gutachter: Robert Magerle ; Betreuer: Werner A. Goedel." Chemnitz : Universitätsbibliothek Chemnitz, 2013. http://d-nb.info/1214245188/34.

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14

Tong, Xiao. "Co-registration of fluorescence diffuse optical tomography (fDOT) with Positron emission tomography (PET) and development of multi-angle fDOT." Thesis, Paris 11, 2012. http://www.theses.fr/2012PA112251/document.

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Ce travail de thèse concerne le traitement d’image fDOT (fDOT pour fluorescence diffuse optical tomography) suit vers deux axes. Le recalage d'images fDOT à l’aide de l’imagerie TEP (tomographie par émission de positons) et l’amélioration des reconstructions fDOT à l’aide de miroirs pour collecter des projections complémentaires. Il est présenté en deux parties : Dans la première partie, une méthode automatique pour recaler les images de fDOT avec les images de Tomographie par Emission de Positons (TEP) développée dans le but de corréler l’ensemble des informations issues de chaque modalité. Cette méthode de recalage est basée sur une détection automatique de marqueurs fiduciaires présents dans les deux modalités. La particularité de cette méthode est l’utilisation de l’image de surface obtenue en fDOT, qui sert à identifier la position en Z des marqueurs fiduciaires dans les images optiques. Nous avons testé cette méthode sur un modèle de souris porteuses de xénogreffes de tumeurs de cellules cancéreuses MEN2A qui imitent un carcinome thyroïdien médullaire humain, après une double injection de traceur radioactif : [18F]2-fluoro-2-Deoxy-D-glucose (FDG) pour l’imagerie TEP et un traceur optique d’infrarouge fluorescent, le Sentidye. Grâce à la précision de notre méthode, nous arrivons à démontrer que le signal Sentidye est présent à la fois dans la tumeur et les vaisseaux environnants [1]. La qualité des images fDOT est dégradée selon l’axe Z du fait d’un nombre limité de projections pour la reconstruction. Dans la deuxième partie, le travail s’est orienté vers une nouvelle méthode de reconstruction d’images fDOT à partir d’un nouveau système d’acquisition multi-angulaire avec deux miroirs placés de chaque côté de l’animal. Ce travail a été mené en collaboration avec le département CS d’University College London (UCL), partenaire du projet Européen FMT-XCT. Le logiciel TOAST développé par cette équipe a été utilisé comme source pour l’algorithme de reconstruction, et modifié pour s’adapter à notre problématique. Après plusieurs essais concernant l’ajustement des paramètres du programme, nous avons appliqué cette méthode sur un fantôme réaliste des tissus biologiques et chez la souris. Les résultats montrent une amélioration de l’image reconstruite d’un fantôme semi-cylindrique et de l’image de rein chez la souris, pour lesquelles la méthode des miroirs est supérieure à la méthode classique sans miroir. Malgré tout, nous avons observé que les résultats étaient très sensibles à certains paramètres, d’où une performance de reconstruction variable d’un cas à l’autre. Les perspectives futures concernent l’optimisation des paramètres afin de généraliser l’approche multi-angle
This thesis concerns the image processing of fluorescence diffuse optical tomography (fDOT), following two axes: FDOT image co-registration with PET (positron emission tomography) image and improvement of fDOT image reconstructions using mirrors to collect additional projections. It is presented in two parts:In the first part, an automatic method to co-register the fDOT images with PET images has been developed to correlate all the information from each modality. This co-registration method is based on automatic detection of fiducial markers (FM) present in both modalities. The particularity of this method is the use of optical surface image obtained in fDOT imaging system, which serves to identify the Z position of FM in optical images. We tested this method on a model of mice bearing tumor xenografts of MEN2A cancer cells that mimic a human medullary thyroid carcinoma, after a double injection of radiotracer [18F] 2-fluoro-2-Deoxy-D-glucose ( FDG) for PET imaging and optical fluorescent infrared tracer Sentidye. With the accuracy of our method, we can demonstrate that the signal of Sentidye is present both in the tumor and surrounding vessels.The fDOT reconstruction image quality is degraded along the Z axis due to a limited number of projections for reconstruction. In the second part, the work is oriented towards a new method of fDOT image reconstruction with a new multi-angle data acquisition system in placing two mirrors on each side of the animal. This work was conducted in collaboration with the CS Department of University College London (UCL), a partner of the European project FMT-XCT. TOAST software developed by this team was used as source code for the reconstruction algorithm, and was modified to adapt to the concerned problem. After several tests on the adjustment of program parameters, we applied this method on a phantom that simulating the biological tissue and on mice. The results showed an improvement in the reconstructed image of a semi-cylindrical phantom and the image of mouse kidney, for which the reconstruction of the mirrors geometry is better than that of conventional geometry without mirror. Nevertheless, we observed that the results were very sensitive to certain parameters, where the performance of reconstruction varies from one case to another. Future prospectives concern the optimization of parameters in order to generalize the multi-angle approach
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15

Vieira, Gustavo Henrique [UNESP]. "Análise molecular de pacientes com síndromes de Smith-Magenis." Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/102693.

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A síndrome de Smith-Magenis (SMS) foi descrita , em 1986, como uma síndrome que envolvia uma mutação na região 17p em 9 pacientes. Sua prevalência esta estimada em um caso a cada 25.000 nascidos vivos. A SMS apresenta fenótipo que inclui características físicas, no desenvolvimento e comportamentais. Os sinais faciais se caracterizam por uma face larga e de forma quadrangular, braquicefalia, frontal proeminente, sinofre, fendas palpebrais alongadas para cima, ponte nasal larga, hipoplasia de face média, nariz largo e achatado, micrognatia na infância com relativa prognatia com a idade e lábio superior protruso e em „v‟ invertido. Os sinais clínicos mais importantes na SMS são comportamentais que levam a autoagressão, hiperatividade e déficit atenção. Foram estudados 31 pacientes brasileiros com suspeita diagnóstica de SMS. As análises genéticas realizadas para avaliar este grupo incluíram técnicas de citogenética molecular (FISH), aCGH, PCR quantitativa e busca por mutações na região de transcrição do gene RAI1. Os resultados demostraram que mais de 90% dos casos neste estudo tinham deficiência mental, atraso no desenvolvimento da fala e comportamento de auto-injúria. Além disso, 30% (9/30) tiveram deleção ou mutação de ponto na região 17p11.2 e RAI1 gene, sendo que 67% apresentaram uma deleção clássica (6/9), 11% tinham uma deleção atípica (1/9) e 22% (2/9) tinham uma mutação no gene RAI1. Foi possível determinar o ponto de quebra das deleções observadas e determinar os genes envolvidos. A deleção atípica descrita neste trabalho atingiu parte do gene RAI e até o momento não havia sido descrita. Além disso, duas mutações de ponto, no exon 3 do gene foram descritas. Por fim, dentro grupo estudado, foi diagnosticado um caso com síndrome da deleção 1p36, sendo possível a sugestão de um novo...
The Smith-Magenis syndrome (SMS) was described in 1986 as a syndrome involving a deletion in the 17p region in 9 patients. Its prevalence is estimated at one case per 25.000 live births. The SMS has phenotype that includes physical and behavioral development. The facial features are characterized by brachycephaly, midface hypoplasia, relative prognatism, everted, tented upper lip and deep-set, close-spaced eyes. The most important clinical features in SMS are leading behavioral self-injury, hyperactivity and attention deficit. We studied 31 Brazilian patients with suggested diagnostic to SMS. The genetic analysis performed to evaluate this group included molecular cytogenetic techniques (FISH), aCGH, quantitative PCR and the search for mutations in the gene transcription RAI1. Results showed that over 90% of the cases in this study had intellectual disability, delayed speech-language development, and self-injurious behavior. Furthermore, 30% had deletion or point mutation in the 17p11.2 region and RAI1 gene. Within this group, we found that 67% carried a classic deletion, 11% had an atypical deletion and 22% had a mutation in the RAI1 gene. It was possible to determine the breakpoint of the deletions observed and to determine the genes involved. The atypical deletion described reached part of the gene RAI1 and to date had not been described. In addition, two point mutations in exon 3 gene have been described. Finally, in this study group, one case was diagnosed with 1p36 deletion syndrome hinting of a possible new Differential Diagnosis for SMS. These findings add information for the etiology of SMS and may facilitate the development of new diagnostic tools, including FISH probes and sequencing-based screening for mutations.
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16

Wilde, Lucy Victoria. "The behavioural and cognitive phenotype of Smith-Magenis syndrome." Thesis, University of Birmingham, 2012. http://etheses.bham.ac.uk//id/eprint/3698/.

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Background: Attention-seeking and impulsivity are reported to be problematic in Smith-Magenis syndrome (SMS) and have been linked to other challenging behaviours including self-injury and aggression. However, limited research has directly examined these aspects of the SMS behavioural phenotype. Method: A survey study refined descriptions of atypical social behaviour. Two further studies directly observed social behaviour, in both naturalistic settings and structured social situations manipulating familiarity of interacting adults and level of attention. A final study evaluated whether response inhibition, measured using cognitive assessments, underpins impulsive behaviour in SMS. Results: Caregivers reported elevated ‘attachment’ to particular people, but not generally elevated sociability. Natural observations revealed preferences for adult attention and manipulations of social variables indicated preference for familiar adults. Impulsivity was not associated with inhibition deficits, however emotional control was. Conclusions: Reports of atypical social behaviour were supported, characterised by seeking attention from familiar adults. Associations between impulsivity and emotional control implicate specific deficits in delay of gratification (whereby delay causes aversive emotional responses). Considering these findings in an integrated model of the SMS behavioural phenotype, including pathways from genetic difference to behaviour and environmental influences, may facilitate targeted interventions for challenging behaviours.
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Vieira, Gustavo Henrique. "Análise molecular de pacientes com síndromes de Smith-Magenis /." Botucatu : [s.n.], 2011. http://hdl.handle.net/11449/102693.

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Orientador: Danilo Moretti-Ferreira
Coorientador: Anand Kumar Srivastava
Banca: Angela Maria Vianna Morgante
Banca: Lucia Regina Martelli
Banca: Claudia Domingues Bonini
Resumo: A síndrome de Smith-Magenis (SMS) foi descrita , em 1986, como uma síndrome que envolvia uma mutação na região 17p em 9 pacientes. Sua prevalência esta estimada em um caso a cada 25.000 nascidos vivos. A SMS apresenta fenótipo que inclui características físicas, no desenvolvimento e comportamentais. Os sinais faciais se caracterizam por uma face larga e de forma quadrangular, braquicefalia, frontal proeminente, sinofre, fendas palpebrais alongadas para cima, ponte nasal larga, hipoplasia de face média, nariz largo e achatado, micrognatia na infância com relativa prognatia com a idade e lábio superior protruso e em „v‟ invertido. Os sinais clínicos mais importantes na SMS são comportamentais que levam a autoagressão, hiperatividade e déficit atenção. Foram estudados 31 pacientes brasileiros com suspeita diagnóstica de SMS. As análises genéticas realizadas para avaliar este grupo incluíram técnicas de citogenética molecular (FISH), aCGH, PCR quantitativa e busca por mutações na região de transcrição do gene RAI1. Os resultados demostraram que mais de 90% dos casos neste estudo tinham deficiência mental, atraso no desenvolvimento da fala e comportamento de auto-injúria. Além disso, 30% (9/30) tiveram deleção ou mutação de ponto na região 17p11.2 e RAI1 gene, sendo que 67% apresentaram uma deleção clássica (6/9), 11% tinham uma deleção atípica (1/9) e 22% (2/9) tinham uma mutação no gene RAI1. Foi possível determinar o ponto de quebra das deleções observadas e determinar os genes envolvidos. A deleção atípica descrita neste trabalho atingiu parte do gene RAI e até o momento não havia sido descrita. Além disso, duas mutações de ponto, no exon 3 do gene foram descritas. Por fim, dentro grupo estudado, foi diagnosticado um caso com síndrome da deleção 1p36, sendo possível a sugestão de um novo... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The Smith-Magenis syndrome (SMS) was described in 1986 as a syndrome involving a deletion in the 17p region in 9 patients. Its prevalence is estimated at one case per 25.000 live births. The SMS has phenotype that includes physical and behavioral development. The facial features are characterized by brachycephaly, midface hypoplasia, relative prognatism, everted, "tented" upper lip and deep-set, close-spaced eyes. The most important clinical features in SMS are leading behavioral self-injury, hyperactivity and attention deficit. We studied 31 Brazilian patients with suggested diagnostic to SMS. The genetic analysis performed to evaluate this group included molecular cytogenetic techniques (FISH), aCGH, quantitative PCR and the search for mutations in the gene transcription RAI1. Results showed that over 90% of the cases in this study had intellectual disability, delayed speech-language development, and self-injurious behavior. Furthermore, 30% had deletion or point mutation in the 17p11.2 region and RAI1 gene. Within this group, we found that 67% carried a classic deletion, 11% had an atypical deletion and 22% had a mutation in the RAI1 gene. It was possible to determine the breakpoint of the deletions observed and to determine the genes involved. The atypical deletion described reached part of the gene RAI1 and to date had not been described. In addition, two point mutations in exon 3 gene have been described. Finally, in this study group, one case was diagnosed with 1p36 deletion syndrome hinting of a possible new Differential Diagnosis for SMS. These findings add information for the etiology of SMS and may facilitate the development of new diagnostic tools, including FISH probes and sequencing-based screening for mutations.
Doutor
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18

Beck, Christian H. "Analyse der Stickoxidbildung in mageren Sprayflammen mit partieller Vorverdunstung." Berlin Logos-Verl, 2009. http://d-nb.info/997726849/04.

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19

Hari, Jürg. "Hypophysen-Nebennieren-Achse bei fetten, stressresistenten und mageren, stressempfindlichen Schweinen /." [S.l.] : [s.n.], 1988. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=8457.

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20

Webber, Carolyn. "Cognitive and behavioural characteristics of children with Smith-Magenis syndrome." Thesis, University of Leicester, 1999. http://hdl.handle.net/2381/31285.

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The study aimed to identify behavioural and cognitive characteristics in 29 children with Smith-Magenis syndrome. Cognitive assessments were undertaken on the children, and detailed interviews assessing sleep patterns, maladaptive behaviours, self-injury, hyperactivity and autism were carried out with their parents and teachers. The study identified high levels of sleep problems, aggression, self-injury, distractibility and autism in the sample, in comparison with rates reported for other groups of children with learning disabilities. These were associated with high levels of stress in the parents. It is concluded that the combination of difficulties and abilities identified in the present sample of children with SMS is indicative of a behavioural phenotype for the syndrome, and that there is an urgent need for intervention studies on the challenging behaviours posed by this group of children.
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21

Gamba, Bruno Faulin [UNESP]. "Estudo citogenético da região 17p11.2: a síndrome de Smith-Magenis." Universidade Estadual Paulista (UNESP), 2010. http://hdl.handle.net/11449/92443.

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Made available in DSpace on 2014-06-11T19:26:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-02-25Bitstream added on 2014-06-13T20:53:57Z : No. of bitstreams: 1 gamba_bf_me_botib.pdf: 1144074 bytes, checksum: 38b7854a72a3108b08ac952129465214 (MD5)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
A síndrome de Smith-Magenis (SMS) é uma complexa anomalia caracterizada por atraso no desenvolvimento neuro-psico-motor (ADNPM), anomalias craniofaciais, esqueléticas e comportamentais. Dentre as anomalias destacamos braquicefalia, baixa estatura, distúrbio do sono, comportamentos de auto-injúria e movimentos estereotipados. SMS é causada por uma deleção intersticial do cromossomo 17(p11.2) ou mutação no gene RAI1, presente nesta região cromossômica. Sua prevalência é estimada em 1:25.000 nascidos vivos podendo chegar até 1:15.000. O diagnóstico clínico para SMS é confirmado pela técnica de citogenética molecular FISH. Neste trabalho realizamos estudo citogenético por bandamento GTG, GTG em alta resolução e FISH no total de 17 casos com suspeita clínica para SMS. Para realização de FISH foram utilizadas duas sondas comerciais da CYTOCELL ®, uma contendo o gene FU1 e outra o gene RAI1. Os resultados clínicos desta casuística comparados com a literatura internacional mostrou que embora fizemos algumas considerações, demonstramos a similaridade do diagnóstico clínico de SMS nos subgrupos SMS-del e SMS-like tanto brasileiros quanto da literatura. Os resultados citogenéticos do bandamento GTG revelaram que sete casos (7/17) apresentam deleção 17(p11.2) e o FISH confirmou a deleção tanto do gene FU1 como do gene RAI1 nos sete casos identificados. Este trabalho é de grande importância por tratar de uma afecção rara, pouco conhecida, e subdiagnosticada no Brasil. Assim destacamos que o uso de ficha clínica específica para SMS é importante para a definição da hipótese diagnóstica, 7/17 casos avaliados apresentaram deleção 17p11.2, e deleção dos genes...
Smith-Magenis syndrome (SMS) is a complex anomaly characterized by developmental delay (ADNPM), craniofacial anomalies, and behavioral disorders. Among the anomalies highlight brachycephaly, short stature, sleep disturbance, behavior of self-injury and stereotyped movements. SMS is caused by an interstitial deletion of chromosome 17 (p11.2) or mutation in the retinoic acid-induced 1 (RAI1) gene, present in this chromosomal region. Its prevalence is estimated at 1:25.000 live births and may reach up to 1:15.000. The c1inical diagnosis for SMS is confirmed by molecular cytogenetic technique of FISH. In this work we performed a cytogenetic study by GTG, GTG high resolution and FISH total of 17 cases with c1inical suspicion for SMS.To perform FISH probes were used two commercial CYTOCELL ®, one containing the FLl1 gene and another gene RAI1. The c1inical results in this series compared to the literature showed that although we made some considerations, we demonstrate the similarity of the clinical diagnosis of SMS in both sub-del SMS and SMS-like Brazilians and literature. The cytogenetic results of GTG banding revealed that seven cases (7 1 17) have deletion 17(p11.2) and FISH confirmed the deletion of both the FLl1 gene and the gene RAI1 the seven cases identified. This work is of great importance for treating arare, little known and under-diagnosed in Brazil. Thus we emphasize that the use of medical records specific to SMS is important to define the diagnosis, 7 117 cases showed stable 17p11.2 deletion, and deletion of genes FUI and RAI, no significant differences between the c1inicalfeatures of this sample group comparing it with the literature and this is about the largest sample of Brazilian SMS already described
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22

Schäfer, Olaf. "Exerimentelle und numerische Analyse des Flammenrückschlags bei der mageren Vormischverbrennung." Berlin Logos-Verl, 2005. http://deposit.ddb.de/cgi-bin/dokserv?id=2695639&prov=M&dok_var=1&dok_ext=htm.

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23

Gamba, Bruno Faulin. "Estudo citogenético da região 17p11.2 : a síndrome de Smith-Magenis /." Botucatu : [s.n.], 2010. http://hdl.handle.net/11449/92443.

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Orientador: Danilo Moretti-Ferreira
Banca: Rodrigo Affonseca Bressan
Banca: Antonia Paula Marques de Faria
Resumo: A síndrome de Smith-Magenis (SMS) é uma complexa anomalia caracterizada por atraso no desenvolvimento neuro-psico-motor (ADNPM), anomalias craniofaciais, esqueléticas e comportamentais. Dentre as anomalias destacamos braquicefalia, baixa estatura, distúrbio do sono, comportamentos de auto-injúria e movimentos estereotipados. SMS é causada por uma deleção intersticial do cromossomo 17(p11.2) ou mutação no gene RAI1, presente nesta região cromossômica. Sua prevalência é estimada em 1:25.000 nascidos vivos podendo chegar até 1:15.000. O diagnóstico clínico para SMS é confirmado pela técnica de citogenética molecular FISH. Neste trabalho realizamos estudo citogenético por bandamento GTG, GTG em alta resolução e FISH no total de 17 casos com suspeita clínica para SMS. Para realização de FISH foram utilizadas duas sondas comerciais da CYTOCELL ®, uma contendo o gene FU1 e outra o gene RAI1. Os resultados clínicos desta casuística comparados com a literatura internacional mostrou que embora fizemos algumas considerações, demonstramos a similaridade do diagnóstico clínico de SMS nos subgrupos SMS-del e SMS-like tanto brasileiros quanto da literatura. Os resultados citogenéticos do bandamento GTG revelaram que sete casos (7/17) apresentam deleção 17(p11.2) e o FISH confirmou a deleção tanto do gene FU1 como do gene RAI1 nos sete casos identificados. Este trabalho é de grande importância por tratar de uma afecção rara, pouco conhecida, e subdiagnosticada no Brasil. Assim destacamos que o uso de ficha clínica específica para SMS é importante para a definição da hipótese diagnóstica, 7/17 casos avaliados apresentaram deleção 17p11.2, e deleção dos genes... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Smith-Magenis syndrome (SMS) is a complex anomaly characterized by developmental delay (ADNPM), craniofacial anomalies, and behavioral disorders. Among the anomalies highlight brachycephaly, short stature, sleep disturbance, behavior of self-injury and stereotyped movements. SMS is caused by an interstitial deletion of chromosome 17 (p11.2) or mutation in the retinoic acid-induced 1 (RAI1) gene, present in this chromosomal region. Its prevalence is estimated at 1:25.000 live births and may reach up to 1:15.000. The c1inical diagnosis for SMS is confirmed by molecular cytogenetic technique of FISH. In this work we performed a cytogenetic study by GTG, GTG high resolution and FISH total of 17 cases with c1inical suspicion for SMS.To perform FISH probes were used two commercial CYTOCELL ®, one containing the FLl1 gene and another gene RAI1. The c1inical results in this series compared to the literature showed that although we made some considerations, we demonstrate the similarity of the clinical diagnosis of SMS in both sub-del SMS and SMS-like Brazilians and literature. The cytogenetic results of GTG banding revealed that seven cases (7 1 17) have deletion 17(p11.2) and FISH confirmed the deletion of both the FLl1 gene and the gene RAI1 the seven cases identified. This work is of great importance for treating arare, little known and under-diagnosed in Brazil. Thus we emphasize that the use of medical records specific to SMS is important to define the diagnosis, 7 117 cases showed stable 17p11.2 deletion, and deletion of genes FUI and RAI, no significant differences between the c1inicalfeatures of this sample group comparing it with the literature and this is about the largest sample of Brazilian SMS already described
Mestre
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24

Behrendt, Thomas. "Strömung und Verbrennung in einem neuen Düsenkonzept für die magere Vormischverbrennung in Fluggasturbinen : 26 Tabellen /." Köln : DLR, Bibliotheks- und Informationswesen, 2003. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=015380553&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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25

Marinov, Svetoslav [Verfasser], and N. [Akademischer Betreuer] Zarzalis. "Untersuchung der Flammenstabilität von geometrisch ähnlichen Brennern für zukünftige magere Triebwerksbrennkammerkonzepte / Svetoslav Marinov. Betreuer: N. Zarzalis." Karlsruhe : KIT-Bibliothek, 2013. http://d-nb.info/1035451077/34.

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26

Schmitz, Ingo. "Magere vorgemischte Verbrennung von leichtem Heizöl in Mikrogasturbinen Grundlagen, Entwurf und experimentelle Untersuchung eines Brenner-, Brennkammersystems." Aachen Shaker, 2009. http://d-nb.info/994882971/04.

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27

SCIARRILLO, MARIA. "IDENTIFICATION OF NOVEL MECHANISMS FOR NEUROLOGICAL CONDITIONS OVERLAPPING SMITH-MAGENIS SYNDROME." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/545630.

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Smith Magenis Syndrome (SMS, OMIM#182290) is a sporadic dominant disorder, with an estimated prevalence of 1:15000-25000 and results from RAI1 gene haploinsufficiency due to either 17p11.2 deletion or RAI1 mutation. SMS has a clinically recognizable phenotype characterized by distinct physical features, neurodevelopmental delay, cognitive impairment and behavioral problems which are reported in 75-100% of SMS cases, and include remarkable sleep disturbance (primarily due to circadian rhythms impairment), stereotypies, maladaptive, self-injurious behavior and sensory processing issues. SMS diagnosis is challenging due to the lack of a striking early childhood facial phenotype, maladaptive behavior that escalates with age, and overlapping syndromes that share with SMS most of the clinical signs and might switch to a differential diagnosis, i.e. 2q23.1 deletion syndrome (OMIM#156200) and Brachydactly Mental Retardation syndrome (BDMR, OMIM#600430). Despite RAI1 is recognized as the disease-causing gene, 50% of patients with a clinical suspicion of SMS do not have the classical genetic defects, thus it is likely that at genomic level other loci different from RAI1, if disrupted, eventually explain SMS similar phenotypes (SMS-like). Hence, even if several animal models support RAI1 crucial contribution to brain development and plasticity, by interacting at chromatin promoter and enhancer regions, compelling evidences on its function, regulators, interactors, and targets are still missing. In order to unveil the molecular basis of SMS-like syndrome and to clarify RAI1 molecular function, the main aim of this project will be a genetic and functional investigation of RAI1 and candidate genes possibly implicated in SMS-like clinical manifestation. A previously selected cohort of 40 SMS-like patients with a clinical suspicion of SMS but without the classical microdeletion at 17p11.2 or RAI1 mutation was available in Medical Cytogenetics and Molecular Genetics Laboratory. High resolution array CGH screening of whole cohort was used to identify Copy Number Variants (CNVs) potentially containing dosage-sensitive genes eventually involved in neurological integrity maintenance, cognition and development, thus putatively implicated in SMS and “SMS-like” clinical condition. Among 40 SMS-like patients cohort the whole genome analysis pinpointed the attention on a CNV, specifically a 54 kb maternal deletion on Xq13.3 (chrX:74772380-74826319, hg19) in one male patient (SMS1). The Xq13.3 deletion does not involve any gene but contains highly conserved region, a predicted insulator and maps 29 kb far from 5’ end of the ZDHHC15 (Zinc Finger DHHC domain-containing protein 15) gene which encodes for palmitoyl-transferase 15 ubiquitously expressed, but highly expressed in the brain. ZDHHC15 was considered an interesting gene possibly implicated in patient phenotype onset due to its function and because was previously associated to a nonsyndromic X-linked intellectual disability. RT-qPCR and digital PCR analyses performed on SMS1 cDNA from peripheral blood revealed a significant downregulation of the ZDHHC15 transcript, supporting that the CNV involving a predicted insulator element results in gene expression alteration by a position effect. Consistent with a possible involvement of ZDHHC15 in SMS-like phenotypes, subsequent Sanger sequencing of all male patients within the cohort was performed and identified a maternally inherited transversion, c.*182A>C, on ZDHHC15 3’UTR in a second male patient (SMS2). In order to clarify any transcriptional effect on ZDHHC15 regulation caused by transversion, both relative RT-qPCR and digital PCR were carried out and allowed to show a slight but not significant ZDHHC15 downregulation in SMS2 cDNA from peripheral blood. Since 3’UTR can be target of several miRNAs playing a role in mRNA regulation, was investigated if in SMS2 the c.*182A>C variant might have altered the normal target region of any miRNAs. Bioinformatic tools enable to select two miRNAs predicted to interact specifically with wild type ZDHHC15 3’UTR (miR-142-5p and miR-5590-3p) and three specifically with mutated ZDHHC15 3’UTR (miR-922; miR-191-5p and miR-4797-5p). Luciferase assay on HEK293T validated a specific and significant effect on wild type ZDHHC15 3’UTR sequence for miR-5590-3p and on mutated ZDHHC15 3’UTR sequence for miR-4797-3p, supporting the initial hypothesis of a possible transcriptional alterations due to A>C transversion. The identification of two different alterations on ZDHHC15 regulatory regions in two unrelated cases in such small cohort of SMS-like patients further supported the possible direct or indirect involvement of ZDHHC15 in RAI1 pathway. To test in vitro whether a transient knockdown of RAI1 and ZDHHC15 would lead to change in expression of genes associated to the regulation of circadian rhythms we used silencing experiments on human BE(2)-M17 neuroblastoma cell line. Both RAI1 and ZDHHC15 silenced cells displayed significant deregulation of expression in up to half of the circadian genes. Moreover, nine out of main sixteen circadian gene proteins tested were predicted to be palmitoylated supporting an eventual role of ZDHHC15 in circadian rhythms control. In silico palmitoylation predictions and silencing experiments corroborate the idea of interconnection among RAI1, ZDHHC15 and circadian rhythms, but further analysis are needed to get a mechanistic insight. In conclusion the combined genomic and functional approach used, highlight ZDHHC15 as a promising candidate gene involved in SMS/SMS-like phenotypes.
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28

Gerth, Stefan [Verfasser], and Andreas [Akademischer Betreuer] Magerl. "Stabilität adsorbierter Polymerschichten an Grenzflächen / Stefan Gerth. Betreuer: Andreas Magerl." Erlangen : Universitätsbibliothek der Universität Erlangen-Nürnberg, 2013. http://d-nb.info/1030182329/34.

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Garay, Daniel Felipe Carnero, Antonio Carbajal Ramos Marcos, Jimmy Armas-Aguirre, and Juan Manuel Madrid Molina. "Information security risk management model for mitigating the impact on SMEs in Peru." IEEE Computer Society, 2020. http://hdl.handle.net/10757/656577.

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El texto completo de este trabajo no está disponible en el Repositorio Académico UPC por restricciones de la casa editorial donde ha sido publicado.
This paper proposes an information security risk management model that allows mitigating the threats to which SMEs in Peru are exposed. According to studies by Ernst Young, 90% of companies in Peru are not prepared to detect security breaches, and 51% have already been attacked. In addition, according to Deloitte, only 10% of companies maintain risk management indicators. The model consists of 3 phases: 1. Inventory the information assets of the company, to conduct the risk analysis of each one; 2. Evaluate treatment that should be given to each risk, 3. Once the controls are implemented, design indicators to help monitor the implemented safeguards. The article focuses on the creation of a model that integrates a standard of risk management across the company with a standard of IS indicators to validate compliance, adding as a contribution the results of implementation in a specific environment. The proposed model was validated in a pharmaceutical SME in Lima, Peru. The results showed a 71% decrease in risk, after applying 15 monitoring and training controls, lowering the status from a critical level to an acceptable level between 1.5 and 2.3, according to the given assessment.
Revisión por pares
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30

Henze, Thomas [Verfasser], Thomas [Akademischer Betreuer] Thurn-Albrecht, Steffen [Akademischer Betreuer] Trimper, and Robert [Akademischer Betreuer] Magerle. "Rasterkraftmikroskopische Untersuchungen an dünnen epitaktisch kristallisierten Filmen des Polyethylens / Thomas Henze. Betreuer: Thomas Thurn-Albrecht ; Steffen Trimper ; Robert Magerle." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2011. http://d-nb.info/1025230531/34.

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Fröbe, Melanie [Verfasser], Robert [Akademischer Betreuer] Magerle, and Borczyskowski Christian [Gutachter] von. "Untersuchung der Fluoreszenzlebensdauer von BODIPY-Farbstoffen in Polymerlösungen und Polymerschmelzen / Melanie Fröbe ; Gutachter: Christian von Borczyskowski ; Betreuer: Robert Magerle." Chemnitz : Universitätsbibliothek Chemnitz, 2016. http://d-nb.info/1214305555/34.

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32

Schmitz, Ingo [Verfasser]. "Magere vorgemischte Verbrennung von leichtem Heizöl in Mikrogasturbinen: Grundlagen, Entwurf und experimentelle Untersuchung eines Brenner-/Brennkammersystems / Ingo Schmitz." Aachen : Shaker, 2009. http://d-nb.info/1156518857/34.

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33

Hough, Tanya M. "Differential reinforcement of other behavior (DRO) in an adult with Smith-Magenis Syndrome." Thesis, Kaplan University, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=1541043.

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The effectiveness of differential reinforcement of other behavior (DRO) with an extinction component was evaluated with two target behaviors with an adult with Smith Magenis Syndrome (SMS) residing in the community who displayed elopement and physical aggression. The intervention included DRO using a fixed-time schedule of reinforcement, paired with extinction when elopement and physical aggression occurred. DRO was demonstrated to be effective in reducing the target behaviors of elopement and physical aggression, resulting in a 79% reduction of elopement and 100% decrease in physical aggression in the group home. Currently, there is a significant need for research using behavioral interventions to decrease challenging behaviors in adults diagnosed with SMS, as very little has been published on this topic.

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34

Leona, Yslado Rocío Mería, and Rojas Rosario Melchora Yataco. "Gestión de riesgos basado en el PMBOK y el Magerit, para implantaciones de sistemas de planeamiento de recursos empresariales (ERP)." Bachelor's thesis, Universidad Nacional Mayor de San Marcos, 2012. https://hdl.handle.net/20.500.12672/12507.

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Publicación a texto completo no autorizada por el autor
Determina la gestión de riegos en cada fase de la implantación de un ERP que son determinantes para el éxito de la optimización e integración de los procesos de negocio, y que a su vez, permiten el logro del máximo rendimiento del sistema. El punto de partida es dar los lineamientos generales en las diferentes fases de la implantación, luego por cada fase se identifican los activos de información, las amenazas más potenciales, el impacto que puede derivar las amenazas, determinar los riesgos y finalmente se desarrollan planes de contingencia y estrategias que minimicen o prevengan los riesgos para poder garantizar la seguridad de los activos. Es muy importante para las empresas que opten por competir en flexibilidad, consistencia y calidad; conocer los riesgos asociados que afectan la implantación del ERP, en los aspectos de centralización, compromiso y liderazgo de la Alta Dirección, adaptación a medida del software, intercambio de información, tipo y esfuerzo de adaptación y accesibilidad de los datos. La gestión de los riesgos asociados es un factor clave para la exitosa implantación de un sistema ERP es por ello que se ha convertido en un punto de gran transcendencia para la Alta Dirección y las personas involucradas.
Trabajo de suficiencia profesional
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35

Alemela, Panduranga Reddy. "Measurement and scaling of acoustic transfer matrices of premixed swirl flames /." München : Verl. Dr. Hut, 2009. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=018673544&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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36

Kettner, Maurice. "Experimentelle und numerische Untersuchungen zur Optimierung der Entflammung von mageren Gemischen bei Ottomotoren mit Direkteinspritzung." Berlin Logos-Verl, 2006. http://deposit.d-nb.de/cgi-bin/dokserv?id=2888451&prov=M&dok_var=1&dok_ext=htm.

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Brückner-Kalb, Jochen Robert. "Sub-ppm-NOx-Verbrennungsverfahren für Gasturbinen." München Verl. Dr. Hut, 2008. http://d-nb.info/990774945/04.

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38

Ax, Holger [Verfasser], and Manfred [Akademischer Betreuer] Aigner. "Experimentelle Untersuchung magerer laminarer Niederdruckflammen mit periodisch variierender Gemischzusammensetzung / Holger Ax. Betreuer: Manfred Aigner." Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2014. http://d-nb.info/1046564579/34.

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39

DAVION, CORINE. "A propos d'une observation de syndrome de smith-magenis (deletion 17 p 11. 2)." Lille 2, 1990. http://www.theses.fr/1990LIL2M005.

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40

Mathon, Julien. "Développement de nouveaux outils algorithmiques et technologiques pour l'étude du mouvement des chromosomes dans la levure S. Cerevisiae." Phd thesis, Université Paul Sabatier - Toulouse III, 2013. http://tel.archives-ouvertes.fr/tel-00949331.

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Le développement des techniques d'ingénierie génétique et celles d'imagerie en microscopie de fluorescence ont ouvert la voie à l'étude du mouvement et de la structure des chromosome dans les cellules vivantes. Depuis quelques années, l'avènement de ces outils a fait naître une biophysique du noyau, dont l'objectif est de comprendre avec des modèles physiques comment s'organise le génome dans une cellule et comment il se réorganise sous l'effet de stimuli biologiques ou chimiques. L'objectif de mon travail de thèse a consisté à développer des outils permettant de mesurer précisément les déplacements des chromosomes dans les cellules vivantes, d'automatiser le processus de traitement des données et de développer des modèles quantitatifs d'analyse des données expérimentales. Dans ce travail de thèse pluridisciplinaire, nous avons à la fois optimisé une chaîne d'acquisition de microscopie de fluorescence afin de maximiser la qualité de films de levures vivantes, réalisé un algorithme de suivi de particules et de reconnaissance de forme dédiés à la levure, ainsi que des outils de traitement automatisés des trajectoires pour systématiser le processus de traitement des données. Ces méthodes ont permis de construire des modèles originaux de structure et de dynamique des chromosomes in vivo chez la levure saccharomyces cerevisiae.
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41

Schob, Stefan [Verfasser], Ralph Gutachter] Meissner, and Hans [Gutachter] [Joosten. "Untersuchungen zum Erhalt des Lebensraumtyps „Magere Flachlandmähwiese“ auf Niedermoorgrünland im Naturpark Ohre - Drömling / Stefan Schob ; Gutachter: Ralph Meissner, Hans Joosten." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2018. http://nbn-resolving.de/urn:nbn:de:gbv:3:4-1981185920-324667.

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Schob, Stefan [Verfasser], Ralph [Gutachter] Meissner, and Hans [Gutachter] Joosten. "Untersuchungen zum Erhalt des Lebensraumtyps „Magere Flachlandmähwiese“ auf Niedermoorgrünland im Naturpark Ohre - Drömling / Stefan Schob ; Gutachter: Ralph Meissner, Hans Joosten." Halle (Saale) : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2018. http://d-nb.info/1210730596/34.

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43

Schildmacher, Kai-Uwe. "Experimentelle Charakterisierung der Instabilitäten vorgemischter Flammen in Gasturbinen-Brennkammern." Berlin Logos-Verl, 2005. http://deposit.ddb.de/cgi-bin/dokserv?id=2671092&prov=M&dok_var=1&dok_ext=htm.

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44

Baumgärtel, Thomas [Verfasser], Borczyskowski Christian [Akademischer Betreuer] von, Borczyskowski Christian [Gutachter] von, and Robert [Gutachter] Magerle. "Binding and characterization of fluorescent nano-aggregates on structured surfaces / Thomas Baumgärtel ; Gutachter: Christian von Borczyskowski, Robert Magerle ; Betreuer: Christian von Borczyskowski." Chemnitz : Universitätsbibliothek Chemnitz, 2012. http://d-nb.info/1214244114/34.

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Bergmann, Christoph [Verfasser], and Andreas [Akademischer Betreuer] Magerl. "Quantitative Analyse diffuser Röntgenstreuung an Sauerstoffnanopräzipitaten in Siliziumeinkristallen / Christoph Bergmann. Gutachter: Andreas Magerl." Erlangen : Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), 2015. http://d-nb.info/1076912052/34.

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Nyman, Lennart. ""Trumman magert altar är Kyrkonyckeln jag begär" : En kollektivbiografisk studie av Frihetstidens fältpräster." Thesis, Uppsala universitet, Kyrkohistoria, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-255521.

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47

Burns, Brooke. "Obesity, Adiposity, and Satiety in mouse models of Smith-Magenis Syndrome and dup(17)(p11.2) Syndrome." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1802.

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Smith-Magenis syndrome (SMS) is a complex disorder caused by haploinsufficiency of RAI1 and characterized by sleep disturbances, behavioral abnormalities, mental retardation, and obesity in teens and adults. Rai1+/- mice are obese after 20 weeks. Dup(17)(p11.2) syndrome is a complex disorder associated with overexpression of RAI1. A transgenic mouse model of dup(17)(p11.2) syndrome overexpresses Rai1 and results in a mouse that is growth delayed. In order to characterize the obese phenotypes of mouse models of SMS and the role of RAI1 in obesity, daily food intake and serum levels of insulin, glucose, PPY, and leptin were measured; adiposity was studied by characterizing fat deposition; and gene expression was studied in the hypothalamus. These studies show that Rai1+/- mice are hyperphagic, consume more during the inactive light phase, and have altered satiety genes in the hypothalamus. Adiposity studies have shown WT females have a higher body fat content and visceral fat proportion than males, but Rai1-Tg and Rai1+/- females have similar fat deposition patterns as WT males. Hypothalamic gene expression studies show that many genes and pathways are affected by Rai1 and Rai1 dosage, including many genes associated with obesity and satiety.
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Flores, Huamani Vladimir, and Rios Manuel Junior Chavez. "Modelo de gestión de riesgos de seguridad de TI para pymes del sector comercial que dependen de proveedores críticos." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2020. http://hdl.handle.net/10757/652324.

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La seguridad de la información se ha convertido en un área importante, ya que las organizaciones diariamente administran activos de TI valiosos que dependen de proveedores críticos; tales como: bases de datos, servicios, aplicaciones, hardware, etc. Estos activos están sometidos a riesgos de una gran variedad, como: desastres naturales, ciberataques, fraudes, etc. que pueden afectar de forma crítica a la organización. Estudios realizados sobre organizaciones en Europa y EE. UU revelan que las Pymes se caracterizan por la falta de la dedicación necesaria a la seguridad de TI. Esto debido principalmente a que la seguridad de la información no forma parte de sus necesidades internas. En el Perú, las empresas no se encuentran preparadas para afrontar situaciones de riesgo, debido a que la mayoría de las organizaciones carecen de políticas de seguridad y sistemas de evaluación de riesgos. El presente proyecto plantea el desarrollo de un modelo de gestión de riesgos de seguridad de TI que tiene como objetivo incrementar el nivel de madurez y disminuir el nivel de riesgo en los procesos y activos de TI de las Pymes que dependen de proveedores críticos. Esto mediante una serie de controles y planes de seguridad basados en la metodología Magerit y estándares de seguridad como la ISO/IEC 27001:2013. Con esto, buscamos cubrir la principal necesidad identificada en las Pymes, la cual es reducir el nivel de impacto ocasionado por los riesgos que afectan los activos y procesos de TI soportados por terceros, y que además puedan contar con un adecuado plan de continuidad.
Information security has become an important area as organizations daily manage valuable IT assets that depend on critical providers; such as: databases, services, applications, hardware, etc. These assets are subject to risks of a wide variety, such as: natural disasters, cyberattacks, fraud, etc. that can critically affect the organization. Studies carried out on organizations in Europe and USA reveal that SMEs are characterized by the lack of dedication necessary to IT security. This is mainly because information security is not part of their internal needs. In Peru, companies are not prepared to face risk situations, since most organizations lack security policies and risk assessment systems. This project proposes the development of an IT security risk management model that aims to increase the level of maturity and decrease the level of risk in the IT processes and assets of SMEs that depend on critical providers. This through a series of controls and security plans based on the Magerit methodology and security standards such as ISO / IEC 27001: 2013. With this, we seek to cover the main need identified in SMEs, which is to reduce the level of impact caused by the risks that affect IT assets and processes supported by third parties, and that may also have an adequate continuity plan.
Tesis
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O'Connor, Michael Ben. "James Magee (1707-1791) and the Belfast print trade, 1771-1781." Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479396.

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Schlegel, Andreas. "Experimentelle und numerische Untersuchung der NOx-Bildung bei der katalytisch stabilisierten und der nicht-katalysierten, mageren Vormischverbrennung /." [S.l.] : [s.n.], 1994. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=10887.

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