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Journal articles on the topic 'Magic markers'

Author: Grafiati

Published: 4 June 2021

Last updated: 27 July 2025

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1

Levy, Campbell L. "Magic markers?" Inflammatory Bowel Diseases 15, no. 2 (2009): 313–14. http://dx.doi.org/10.1002/ibd.20626.

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2

Barker, P., and S. Millroy. "Tumour Markers - Magic or Menace?" Journal of The Royal Naval Medical Service 87, no. 3 (2001): 148–52. http://dx.doi.org/10.1136/jrnms-87-148.

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AbstractBreast cancer follow-up is aimed at the detection of metastatic disease at a stage when it can still be treated. Traditionally this has been done on a symptomatic basis confirmed by UICC criteria. By inference, tumour burden by this time is likely to be high, and therefore any therapy possibly less effective.Breast Serum Tumour Marker estimation, while disease volume is still low, has been shown in a District General Hospital setting to allow early treatment and monitor efficacy of therapy. A randomised multi-centre study is essential to determine whether these investigations are sensi

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3

Silverstein, Arthur M. "Labeled antigens and antibodies: the evolution of magic markers and magic bullets." Nature Immunology 5, no. 12 (2004): 1211–17. http://dx.doi.org/10.1038/ni1140.

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4

Vermeire, S. "Laboratory markers in IBD: useful, magic, or unnecessary toys?" Gut 55, no. 3 (2006): 426–31. http://dx.doi.org/10.1136/gut.2005.069476.

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5

Yudono, Kristophorus Divinanto Adi, Godang Lamtiur Sitanggang, and Nugroho Widiyanto. "Realisme Magis dalam Naskah Drama Kejahatan Membalas Dendam Karya Idrus Tahun 1948." Indonesian Journal of Performing Arts Education 3, no. 1 (2023): 8–14. http://dx.doi.org/10.24821/ijopaed.v3i1.8602.

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AbstrakRealisme magis merupakan karya sastra yang mengaburkan batas antara nalar dan luar nalar. Aliran ini tidak terlepas dari masyarakat Indonesia dengan masing-masing kepercayaan berkaitan magis/mistis yang merupakan unsur kebudayaan. Kajian ini dilakukan untuk menganalisis dan mendeskripsikan unsur realisme magis yang terdapat pada naskah drama Kejahatan Membalas Dendam karya Idrus. Analisis realisme magis pada naskah drama dilakukan berdasarkan penanda realisme magis yang dipetakan oleh Wendy Bush Faris. Pendekatan kajian ini adalah kualitatif deskriptif. Teknik dokumentasi literatur dila

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Smyth, Elizabeth Catherine, Sanna Hulkki Wilson, Matthew Guy Nankivell, et al. "Prognostic and predictive effect of microsatellite instability (MSI) in MAGIC." Journal of Clinical Oncology 33, no. 3_suppl (2015): 62. http://dx.doi.org/10.1200/jco.2015.33.3_suppl.62.

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62 Background: MSI is prognostic for survival in diverse cancers and predicts resistance to fluoropyrimidine chemotherapy in colon cancer. We examined the interaction between MSI and patient (pt) characteristics and survival for pts randomised to surgery alone or perioperative ECF chemotherapy in the MRC MAGIC trial. Methods: Tumor and normal control DNA was extracted from resection FFPE. MSI status was determined using the Promega MSI Analysis System (NR-21, BAT-26, BAT-25, NR-24, MONO-27). Tumors were classified as MSS when all markers were stable, MSI-L when only one marker was unstable and

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Papp, Maria. "Utility of serological markers in inflammatory bowel diseases: Gadget or magic?" World Journal of Gastroenterology 13, no. 14 (2007): 2028. http://dx.doi.org/10.3748/wjg.v13.i14.2028.

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8

Johnston, Sean. "Holograms: The Story of a Word and Its Cultural Uses." Leonardo 50, no. 5 (2017): 493–99. http://dx.doi.org/10.1162/leon_a_01329.

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Holograms reached popular consciousness during the 1960s and have since left audiences alternately fascinated, bemused or inspired. Their impact was conditioned by earlier cultural associations and successive reimaginings by wider publics. Attaining peak public visibility during the 1980s, holograms have been found more in our pockets (as identity documents) and in our minds (as video-gaming fantasies and “faux hologram” performers) than in front of our eyes. The most enduring, popular interpretations of the word “hologram” evoke the traditional allure of magic and galvanize hopeful technologi

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Xu, Wenjuan, HaiYan Cao, Fang Du, Ling He, FangLian Jiang, and ChunHong Hu. "Magnetic Resonance Image Compilation Was Used in Conjunction with Prostate PI-RADS v2.1 Score Has Diagnostic Relevance for Benign and Malignant Prostate Lesions." Computational and Mathematical Methods in Medicine 2022 (August 29, 2022): 1–10. http://dx.doi.org/10.1155/2022/3613540.

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Objective. To assess the diagnostic usefulness of magic in conjunction with PI-RADS v2.1 for prostate cancer malignant foci. Methods. A total of 202 lesions (97 transitional zone lesions and 105 peripheral zone lesions) from 198 people were investigated retrospectively using traditional MRI and magic images. Each lesion has a unique pathological consequence. Lesions T1, T2, and PD values were employed as magic observation markers. The locations of the lesions were aggregated, and the paired t -test and receiver operating characteristic curve (ROC) were employed to find the indices with statist

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10

Osiyanova, Olga M., and Svetlana A. Cherasheva. "MAGIC AND MEANS OF ITS EXPRESSION IN LITERATURE OF FANTASY GENRE." Sovremennye issledovaniya sotsialnykh problem 14, no. 2 (2022): 336–52. http://dx.doi.org/10.12731/2077-1770-2022-14-2-336-352.

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Background. The relevance of the research topic is due to the growing popularity of the fantasy genre and the insufficient study of the issue of systematizing the means of expressing the magical in fiction. Purpose. The purpose of the article is to define the essence of the magical, to reveal its cognitive features and means of expression. Materials and methods. The practical material for the study was the texts of works of the fantasy genre fiction: Wolfhound by M. Semenova, The Mage of Midnight by D. Yemets, Temple of the Winds by T. Goodkind, The Chronicles of Amber by R. Zelazn

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11

Kityo, R., P. O. Ongom, J. Karungi, et al. "Genome-wide association study reveals single nucleotide polymorphisms and candidate genes for resistance of cowpea to aphids." African Crop Science Journal 32, no. 4 (2025): 375–91. https://doi.org/10.4314/acsj.v32i4.5.

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Cowpea (Vigna unguiculata L. Walp.) is a major crop grown mainly in the arid and semi-arid regions for food and nutritional security. Its production, however, is generally hampered by its susceptibility to sap-sacking aphids (Aphis craccivora Koch). Resistance breeding for cowpea improvement against aphids, has been limited by inadequate understanding of genes responsible for resistance to this cosmopolitan pest. The objective of this study was to identify single nucleotide polymorphisms (SNPs) and candidate genes, associated with resistance of cowpea to aphids. The study evaluated 209 genotyp

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12

Smyth, Elizabeth Catherine, Iain BeeHuat Tan, David Cunningham, et al. "MAGIC trial gene expression profiling study." Journal of Clinical Oncology 31, no. 15_suppl (2013): 4020. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.4020.

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4020 Background: The MRC MAGIC trial established perioperative epirubicin, cisplatin and 5FU (ECF) chemotherapy as a standard of care for patients (pts) with operable oesophagogastric (OG) cancer (Cunningham NEJM 2006). We performed transcriptomic profiling of archival MAGIC tissue to evaluate an existing intrinsic gastric cancer (GC) gene signature, to describe expression patterns of biologically informative genes and to identify prognostic or predictive markers. Methods: RNA was extracted from formalin fixed paraffin embedded (FFPE) resections and analysed with the NanoString nCounter system

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Tytun, Oksana, and Olga Derkachova. "ESSENCE OF OBJECTS IN LYMAN FRANK BAUM’S TALES." LITERARY PROCESS: methodology, names, trends, no. 19 (2022): 39–46. http://dx.doi.org/10.28925/2412-2475.2022.19.5.

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The article deals with the research on the essence of objects in children’s literature (on the book "American Tales" by L.F. Baum). The daily routine is skillfully combined with fairy-tale mood, it becomes possible due to the characters and the objects in these tales. The article describes the possible functions of objects in fiction, in particular, in a literary tale. The main attention is paid to the definition of functions performed by objects in the given fairy tales and the role of magic and magical objects in these works because the presence of magic objects in the text is one of the mar

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Mochocka, Aleksandra, and Radosław Piotr Walczak. "Focalization, Subjectivity, and Magic(al) Realism in “Night in the Woods”." Anglica Wratislaviensia 61, no. 2 (2024): 77–92. http://dx.doi.org/10.19195/0301-7966.61.2.6.

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The main aim of our analysis is to consider the use and function of focalization in Night in the Woods (Infinite Fall, 2017) and the resulting magic(al) realism subjectivity of perception and fluidity of the gameworld in the framework of post-classical narratology. Our suggestion is that the specific ludonarrative features and functions of the game and its playable protagonist, Mae Borowski, pose questions pertaining to the ontological status of the gameworld, making it an in-between, undetermined magic(al) realism space. Taking into account the conventional formulas and themes utilized in the

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Aapro, Matti. "The Role of Multigene Assays in Addressing Treatment Heterogeneity for Breast Cancer." Biomedicine Hub 2, Suppl. 1 (2017): 1–3. http://dx.doi.org/10.1159/000481247.

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Breast cancer has a complex biology with heterogeneous treatment approaches that have changed significantly over the last two decades. The MAGIC survey provides valuable insight into worldwide treatment recommendations for early breast cancer patients and the clinical and pathologic criteria used for these decisions. The overall findings indicate that there is substantial heterogeneity in how patients are treated and a substantial uncertainty in treatment recommendations for a large proportion of patients, highlighting an unmet need for broadly available markers, such as multigene assays, that

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Tasic, Ljubica, Nataša Avramović, Milka Jadranin, et al. "High-Resolution Magic-Angle-Spinning NMR in Revealing Hepatoblastoma Hallmarks." Biomedicines 10, no. 12 (2022): 3091. http://dx.doi.org/10.3390/biomedicines10123091.

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Cancer is one of the leading causes of death in children and adolescents worldwide; among the types of liver cancer, hepatoblastoma (HBL) is the most common in childhood. Although it affects only two to three individuals in a million, it is mostly asymptomatic at diagnosis, so by the time it is detected it has already advanced. There are specific recommendations regarding HBL treatment, and ongoing studies to stratify the risks of HBL, understand the pathology, and predict prognostics and survival rates. Although magnetic resonance imaging spectroscopy is frequently used in diagnostics of HBL,

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17

Culina, Slobodan, Christian Boitard, and Roberto Mallone. "Antigen-Based Immune Therapeutics for Type 1 Diabetes: Magic Bullets or Ordinary Blanks?" Clinical and Developmental Immunology 2011 (2011): 1–15. http://dx.doi.org/10.1155/2011/286248.

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The ideal drug of modern medicine is the one that achieves its therapeutic target with minimal adverse effects. Immune therapy of Type 1 diabetes (T1D) is no exception, and knowledge of the antigens targeted by pathogenic T cells offers a unique opportunity towards this goal. Different antigen formulations are being considered, such as proteins or peptides, either in their native form or modifiedad hoc, DNA plasmids, and cell-based agents. Translation from mouse to human should take into account important differences, particularly in the time scale of autoimmune progression, and intervention.

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18

Shibata, Fumi, Yuko Goto-Koshino, Miyuki Ito, et al. "Robo4/Magic Roundabout Is a Novel Surface Marker for Murine and Human Hematopoietic Stem Cells." Blood 108, no. 11 (2006): 682. http://dx.doi.org/10.1182/blood.v108.11.682.682.

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Abstract A variety of cell surface markers such as c-Kit, Sca-1, CD34 and Flt-3 have been utilized to prospectively isolate murine or human hematopoietic stem cells (HSCs). While murine HSCs were shown to be highly enriched in CD34−c-Kit+Sca-1+Lineage- (CD34−KSL) fraction, this population is still not homogeneous for long-term HSCs. In human, CD34+ cells are regarded as crude HSC fraction and used for clinical applications. However, quiescent human HSCs are also found in CD34− fraction, indicating that CD34 is not a bona fide marker for human HSC. Thus, novel surface markers that can be used t

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19

Sewify, Khaled, Ahmed R Shoala, Abdelaziz Alshaer, Ashraf Amin, and Rehab Y AL-Ansari. "Could nebulized heparin be the magic treatment for COVID-19 Pneumonia and ARDS?" Journal of Anesthesia and Critical Care: Open access 13, no. 6 (2021): 182–88. http://dx.doi.org/10.15406/jaccoa.2021.13.00494.

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Background: The global spread of the novel strain of coronavirus referred to as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in the continuous rise in the hospitalization of people suffering from COVID-19 in various parts of the world. The predominant symptoms experienced by patients diagnosed with SARS-CoV-2 infection include pneumonia and acute respiratory distress syndrome (ARDS). These symptoms have contributed to the high mortality rate of COVID-19 patients across the globe. Recent studies have indicated that nebulized unfractionated heparin (UFH) can be emplo

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Stenman, Katarina, Pär Stattin, Hans Stenlund, Katrine Riklund, Gerhard Gröbner, and Anders Bergh. "H HRMAS NMR Derived Bio-markers Related to Tumor Grade, Tumor Cell Fraction, and Cell Proliferation in Prostate Tissue Samples." Biomarker Insights 6 (January 2011): BMI.S6794. http://dx.doi.org/10.4137/bmi.s6794.

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A high-resolution magic angle spinning NMR spectroscopic approach is presented for evaluating the occurrence, amount and aggressiveness of cancer in human prostate tissue samples. Using this technique, key metabolites in malignant and non-malignant samples (n = 149) were identified, and patterns of their relative abundance were analyzed by multivariate statistical methods. Ratios of various metabolites – including (glycerophophorylcholine + phosphorylcholine)/creatine, myo-inositol/scyllo-inositol, scyllo-inositol/creatine, choline/creatine, and citrate/creatine – correlated with: i) for non-m

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Saad, Hebatallah M., Ghada F. Tourky, Hayder M. Al-kuraishy, et al. "The Potential Role of MUC16 (CA125) Biomarker in Lung Cancer: A Magic Biomarker but with Adversity." Diagnostics 12, no. 12 (2022): 2985. http://dx.doi.org/10.3390/diagnostics12122985.

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Lung cancer is the second most commonly diagnosed cancer in the world. In terms of the diagnosis of lung cancer, combination carcinoembryonic antigen (CEA) and cancer antigen 125 (CA125) detection had higher sensitivity, specificity, and diagnostic odds ratios than CEA detection alone. Most individuals with elevated serum CA125 levels had lung cancer that was either in stage 3 or stage 4. Serum CA125 levels were similarly elevated in lung cancer patients who also had pleural effusions or ascites. Furthermore, there is strong evidence that human lung cancer produces CA125 in vitro, which sugges

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Reynolds, John V., Shaun R. Preston, Brian O'Neill, et al. "Neo-AEGIS (Neoadjuvant trial in Adenocarcinoma of the Esophagus and Esophago-Gastric Junction International Study): Preliminary results of phase III RCT of CROSS versus perioperative chemotherapy (Modified MAGIC or FLOT protocol). (NCT01726452)." Journal of Clinical Oncology 39, no. 15_suppl (2021): 4004. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.4004.

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4004 Background: The optimum combination curative approach to locally advanced adenocarcinoma of the esophagus and esophago-gastric junction (AEG) is unknown. A key question is whether neoadjuvant multimodal therapy, specifically CROSS (carboplatin/paclitaxel, 41.4Gy radiation therapy), is superior to optimum peri-operative chemotherapeutic regimens including modified MAGIC (epirubicin, cisplatin (oxaliplatin), 5-FU (capecitabine)) and more latterly FLOT (docetaxel, 5-FU, leucovorin, oxaliplatin). Neo-AEGIS was designed as the first randomised controlled trial to address this question. Methods

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Reynolds, John V., Shaun R. Preston, Brian O'Neill, et al. "Neo-AEGIS (Neoadjuvant Trial in Adenocarcinoma of the Esophagus and Esophago-Gastric Junction International Study): Final primary outcome analysis." Journal of Clinical Oncology 41, no. 4_suppl (2023): 295. http://dx.doi.org/10.1200/jco.2023.41.4_suppl.295.

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295 Background: The optimum combination curative approach to locally advanced adenocarcinoma of the esophagus and esophago-gastric junction (AEG) remains controversial, specifically whether multimodal therapy or perioperative chemotherapy is superior. Neo-AEGIS was designed as the first randomized clinical trial (RCT) to directly compare the multimodal CROSS regimen (carboplatin/paclitaxel, 41.4Gy radiation therapy) with a modified MAGIC (epirubicin, cisplatin (oxaliplatin), 5-FU (capecitabine)) regimen (pre-2018) and more latterly the FLOT (docetaxel, 5-FU, leucovorin, oxaliplatin) regimen. M

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Романова, Наталя. "СЕМАНТИКА ПОРІВНЯНЬ ЯК МАРКЕРІВ БАЗОВИХ ЕМОЦІЙ (НА МАТЕРІАЛІ УКРАЇНСЬКИХ ГЕРОЇКО- ФАНТАСТИЧНИХ КАЗОК, ПЕРЕКЛАДЕНИХ НІМЕЦЬКОЮ МОВОЮ)". Inozenma Philologia, № 134 (15 грудня 2021): 38–47. http://dx.doi.org/10.30970/fpl.2021.134.3509.

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The article focuses on the study of semantics of comparisons as markers of basic emotions in Ukrainian heroic-fantastic fairy tales translated into German. In the fi eld of linguistics, the comparison transforms from logical to artistic correlating with the type of poetic thinking which forms, develops, changes, and evolves within the cultural and historical development of mankind in general and ethnos in particular. The methodological basis of the semantics of comparisons as markers of basic emotions is formed by the anthropocentric paradigm of modern linguistics (F. S. Batsevych, E. S. Kubry

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Kim, Tae-Heon, and Suk-Man Kim. "Identification of Candidate Genes for Salt Tolerance at the Seedling Stage Using Integrated Genome-Wide Association Study and Transcriptome Analysis in Rice." Plants 12, no. 6 (2023): 1401. http://dx.doi.org/10.3390/plants12061401.

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Salt stress is a major constraint in rice production worldwide. Salt stress is estimated to cause annual losses of 30–50% in rice production. Discovering and deploying salt-resistance genes are the most effective ways to control salt stress. We performed a genome-wide association study (GWAS) to detect QTLs related to salt tolerance at the seedling stage using the japonica-multiparent advanced generation intercross (MAGIC) population. Four QTLs (qDTS1-1, qDTS1-2, qDTS2, and qDTS9) associated with salt tolerance were identified on chromosomes 1, 2, and 9. Among these QTLs, a novel QTL, qDTS1-2,

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26

Hölscher, Arnulf H., and Benjamin Babic. "New approaches in esophageal carcinomas." Innovative Surgical Sciences 1, no. 2 (2016): 87–95. http://dx.doi.org/10.1515/iss-2016-0020.

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AbstractNew approaches in the treatment of esophageal cancer comprise endoscopy with refinements of esophagoscopic intraluminal resection by endoscopic submucosal dissection. Radical open surgery is more and more replaced by minimally invasive esophagectomy (MIO), especially in the hybrid technique with laparoscopic gastrolysis and transthoracic esophageal resection and gastric pull-up. Total MIO also in the robotic technique has not yet shown that it produces superior results than the hybrid technique. Fluorescent dye can improve the intraoperative visualization of the vascularization of the

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Butrón, A., R. Santiago, A. Cao, L. F. Samayoa, and R. A. Malvar. "QTLs for Resistance to Fusarium Ear Rot in a Multiparent Advanced Generation Intercross (MAGIC) Maize Population." Plant Disease 103, no. 5 (2019): 897–904. http://dx.doi.org/10.1094/pdis-09-18-1669-re.

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Alternative approaches to linkage and association mapping using inbred panels may allow further insights into loci involved in resistance to Fusarium ear rot and lead to the discovery of suitable markers for breeding programs. Here, the suitability of a maize multiparent advanced-generation intercross population for detecting quantitative trait loci (QTLs) associated with Fusarium ear rot resistance was evaluated and found to be valuable in uncovering genomic regions containing resistance-associated loci in temperate materials. In total, 13 putative minor QTLs were located over all of the chro

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HNIZDILOVA, O. "FORMATION OF PRESCHOOLERS’ CREATIVITY BY MEANS OF MODERN GAME AND ART MATERIALS WITH MAGIC-EFFECT." Pedagogical Sciences, no. 78 (December 29, 2021): 5–10. http://dx.doi.org/10.33989/2524-2474.2021.78.249778.

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The issue of preschool children’s creativity formation by means of game and art materials with magic-effect isconsidered in the paper.It has been found that, in the current conditions of globalization, the child starting from their first year is surrounded by an environment filled with various processes, problems, changes, and transformations. It highlights the need and importance of creativity formation starting from preschool age. The modern information society places high demands on the competence of the younger generation and actively influences its formation. The paper provides a brief an

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Ilea, Aranka, Vlad Andrei, Claudia Feurdean, et al. "Saliva, a Magic Biofluid Available for Multilevel Assessment and a Mirror of General Health—A Systematic Review." Biosensors 9, no. 1 (2019): 27. http://dx.doi.org/10.3390/bios9010027.

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Background: Saliva has been recently proposed as an alternative to classic biofluid analyses due to both availability and reliability regarding the evaluation of various biomarkers. Biosensors have been designed for the assessment of a wide spectrum of compounds, aiding in the screening, diagnosis, and monitoring of pathologies and treatment efficiency. This literature review aims to present the development in the biosensors research and their utility using salivary assessment. Methods: a comprehensive literature search has been conducted in the PubMed database, using the keywords “saliva” and

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Lopez-Malvar, Ana, Rosa Ana Malvar, Ana Butron, Pedro Revilla, Sonia Pereira-Crespo, and Rogelio Santiago. "Genetic Dissection for Maize Forage Digestibility Traits in a Multi-Parent Advanced Generation Intercross (MAGIC) Population." Agronomy 11, no. 1 (2021): 104. http://dx.doi.org/10.3390/agronomy11010104.

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Forage feedstock is the greatest source of energy for livestock. Unfortunately, less than 50% of their fiber content is actually digested and assimilated by the ruminant animals. This recalcitrance is mainly due to the high concentration of plant cell wall material and to the limited digestion of the fiber by the microorganisms. A Genome-Wide Association Study (GWAS) was carried out in order to identify Single Nucleotide Polymorphisms (SNPs) associated with forage digestibility traits in a maize Multi-Parent Advanced Generation Intercross (MAGIC) population. We identified seven SNPs, correspon

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Lopez-Malvar, Ana, Rosa Ana Malvar, Ana Butron, Pedro Revilla, Sonia Pereira-Crespo, and Rogelio Santiago. "Genetic Dissection for Maize Forage Digestibility Traits in a Multi-Parent Advanced Generation Intercross (MAGIC) Population." Agronomy 11, no. 1 (2021): 104. http://dx.doi.org/10.3390/agronomy11010104.

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Forage feedstock is the greatest source of energy for livestock. Unfortunately, less than 50% of their fiber content is actually digested and assimilated by the ruminant animals. This recalcitrance is mainly due to the high concentration of plant cell wall material and to the limited digestion of the fiber by the microorganisms. A Genome-Wide Association Study (GWAS) was carried out in order to identify Single Nucleotide Polymorphisms (SNPs) associated with forage digestibility traits in a maize Multi-Parent Advanced Generation Intercross (MAGIC) population. We identified seven SNPs, correspon

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32

Gori, Anna Maria, Betti Giusti, Benedetta Piccardi, et al. "Inflammatory and metalloproteinases profiles predict three-month poor outcomes in ischemic stroke treated with thrombolysis." Journal of Cerebral Blood Flow & Metabolism 37, no. 9 (2017): 3253–61. http://dx.doi.org/10.1177/0271678x17695572.

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Inflammatory mediators and metalloproteinases are altered in acute ischemic stroke (AIS) and play a detrimental effect on clinical severity and hemorrhagic transformation of the ischemic brain lesion. Using data from the Italian multicenter observational MAGIC (MArker bioloGici nell’Ictus Cerebrale) Study, we evaluated the effect of inflammatory and metalloproteinases profiles on three-month functional outcome, hemorrhagic transformation and mortality in 327 patients with AIS treated with intravenous thrombolys in according to SITS-MOST (Safe Implementation of Thrombolysis in Stroke-MOnitoring

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Andrews, Tallulah S., and Martin Hemberg. "False signals induced by single-cell imputation." F1000Research 7 (March 5, 2019): 1740. http://dx.doi.org/10.12688/f1000research.16613.2.

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Background: Single-cell RNA-seq is a powerful tool for measuring gene expression at the resolution of individual cells. A challenge in the analysis of this data is the large amount of zero values, representing either missing data or no expression. Several imputation approaches have been proposed to address this issue, but they generally rely on structure inherent to the dataset under consideration they may not provide any additional information, hence, are limited by the information contained therein and the validity of their assumptions. Methods: We evaluated the risk of generating false posi

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Toulouze, Eva, and Tatiana Vladykina. "How do Udmurts address their God(s)?" Incantatio. An International Journal on Charms, Charmers and Charming 11 (December 2023): 26–55. http://dx.doi.org/10.7592/incantatio2023_11_toulouze_tatiana.

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This article relies on a long-term fieldwork experience: Eva Toulouze has attended Udmurt animistic ceremonies in Bashkortostan over a period of ten years and has collected there the uttered prayers. These prayers are the corpus upon which our linguistic reflections are articulated. The language of the prayers represents a particular register of the Udmurt language. They are deeply dialectal, and while today they are mostly transmitted through writing and the magic aspect is less emphasised, they belong to the oral tradition of incantations. In this article, we comment upon some of the peculia

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Campanioni, Chris. "Magic Marker." Massachusetts Review 64, no. 1 (2023): 54–62. http://dx.doi.org/10.1353/mar.2023.0006.

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36

Pavan, Alberto, Elisabetta Zulato, Lorenzo Calvetti, et al. "Plasma next-generation sequencing (NGS) in advanced non-small cell lung cancer (aNSCLC) patients (pts) treated with immune checkpoint inhibitors (ICIs): Impact of STK11 and TP53 mutations on outcome." Journal of Clinical Oncology 38, no. 15_suppl (2020): 3046. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3046.

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3046 Background: ICIs revolutionized aNSCLC treatment. The next challenge lays on the search for predictive markers. Detection of multiple tumor-related genetic alterations through NGS in cell free DNA is a promising tool, provided the limited availability of tumor tissue in most cases. Methods: Between January 2017 and October 2019, aNSCLC pts consecutively referring to our Institution were prospectively screened with plasma NGS while included in two clinical trials: VISION (NCT02864992) and MAGIC trial, an observational study. In VISION trial NGS was performed in plasma (Guardant360 test) an

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Jairam, Rajeev, Mukesh Prabhuswamy, and Pravin Dullur. "Do We Really Know How to Treat a Child with Bipolar Disorder or One with Severe Mood Dysregulation? Is There a Magic Bullet?" Depression Research and Treatment 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/967302.

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Background. Despite controversy, bipolar disorder (BD) is being increasingly diagnosed in under 18s. There is scant information regarding its treatment and uncertainty regarding the status of “severe mood dysregulation (SMD)” and how it overlaps with BD. This article collates available research on treatment of BD in under 18s and explores the status of SMD.Methods. Literature on treatment of BD in under 18s and on SMD were identified using major search engines; these were then collated and reviewed.Results. Some markers have been proposed to differentiate BD from disruptive behaviour disorders

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Spudis, Edward V. "Magic Marker Memorial." Clinical Pediatrics 40, no. 7 (2001): 424. http://dx.doi.org/10.1177/000992280104000717.

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Courant, Florestan, Marion Maravat, Wanyin Chen, et al. "Expression of the Human Serotonin 5-HT7 Receptor Rescues Phenotype Profile and Restores Dysregulated Biomarkers in a Drosophila melanogaster Glioma Model." Cells 11, no. 8 (2022): 1281. http://dx.doi.org/10.3390/cells11081281.

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Gliomas are the most common primary brain tumors in adults. Significant progress has been made in recent years in identifying the molecular alterations involved in gliomas. Among them, an amplification/overexpression of the EGFR (Epidermal Growth Factor Receptor) proto-oncogene and its associated signaling pathways have been widely described. However, current treatments remain ineffective for glioblastomas, the most severe forms. Thus, the identification of other pharmacological targets could open new therapeutic avenues. We used a glioma model in Drosophila melanogaster that results from the

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Riaz, Adnan, Petra KockAppelgren, James Gerard Hehir, et al. "Genetic Analysis Using a Multi-Parent Wheat Population Identifies Novel Sources of Septoria Tritici Blotch Resistance." Genes 11, no. 8 (2020): 887. http://dx.doi.org/10.3390/genes11080887.

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Zymoseptoria tritici is the causative fungal pathogen of septoria tritici blotch (STB) disease of wheat (Triticum aestivum L.) that continuously threatens wheat crops in Ireland and throughout Europe. Under favorable conditions, STB can cause up to 50% yield losses if left untreated. STB is commonly controlled with fungicides; however, a combination of Z. tritici populations developing fungicide resistance and increased restrictions on fungicide use in the EU has led to farmers relying on fewer active substances. Consequently, this serves to drive the emergence of Z. tritici resistance against

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Mesti, Tanja, Nadia Bouchemal, Claire Banissi, et al. "Nuclear magnetic resonance metabolic fingerprint of bevacizumab in mutant IDH1 glioma cells." Radiology and Oncology 52, no. 4 (2018): 392–98. http://dx.doi.org/10.2478/raon-2018-0046.

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AbstractBackgroundMalignant gliomas are rapidly growing tumours that extensively invade the brain and have bad prognosis. Our study was performed to assess the metabolic effects of bevacizumab on the glioma cells carrying the IDH1 mutation, a mutation, associated with better prognosis and treatment outcome. Bevacizumab is known to inhibit tumour growth by neutralizing the biological activity of vascular endothelial growth factor (VEGF). However, the direct effects of bevacizumab on tumour cells metabolism remain poorly known.Materials and methodsThe immunoassay and MTT assay were used to asses

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Bennett, Christopher, Sarah Kohe, Florence Burte, et al. "MBRS-69. METABOLITE PROFILING OF SHH MEDULLOBLASTOMA IDENTIFIES A SUBSET OF CHILDHOOD TUMOURS ENRICHED FOR HIGH-RISK MOLECULAR BIOMARKERS AND CLINICAL FEATURES." Neuro-Oncology 22, Supplement_3 (2020): iii410. http://dx.doi.org/10.1093/neuonc/noaa222.573.

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Abstract SHH medulloblastoma patients have a variable prognosis. Infants (&lt;3–5 years at diagnosis) are associated with a good prognosis, while disease-course in childhood is associated with specific prognostic biomarkers (MYCN amplification, TP53 mutation, LCA histology; all high-risk). There is an unmet need to identify prognostic subgroups of SHH tumours rapidly in the clinical setting, to aid in real-time risk stratification and disease management. Metabolite profiling is a powerful technique for characterising tumours. High resolution magic angle spinning NMR spectroscopy (HR-MAS) c

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Imperiale, Alessio, Karim Elbayed, François-Marie Moussallieh, et al. "Metabolomic profile of the adrenal gland: from physiology to pathological conditions." Endocrine-Related Cancer 20, no. 5 (2013): 705–16. http://dx.doi.org/10.1530/erc-13-0232.

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In this study, we i) assessed the metabolic profile of the normal adrenal cortex and medulla of adult human subjects by means of1H-high-resolution magic-angle spinning nuclear magnetic resonance (HRMAS NMR) spectroscopy; ii) compared the biochemical profile of adenoma (Ad), adrenal cortical carcinoma (ACC), and pheochromocytoma (PCC) samples with that of healthy adrenal tissue samples; and iii) investigated the metabolic differences between ACCs and Ads as well as between ACCs and PCCs. Sixty-six tissue samples (13 adrenal cortical tissue, eight medullary tissue, 13 Ad, 12 ACC, and 20 PCC samp

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Andrews, Tallulah S., and Martin Hemberg. "False signals induced by single-cell imputation." F1000Research 7 (November 2, 2018): 1740. http://dx.doi.org/10.12688/f1000research.16613.1.

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Background: Single-cell RNASeq is a powerful tool for measuring gene expression at the resolution of individual cells. A significant challenge in the analysis of this data is the large amount of zero values, representing either missing data or no expression. Several imputation approaches have been proposed to deal with this issue, but since these methods generally rely on structure inherent to the dataset under consideration they may not provide any additional information. Methods: We evaluated the risk of generating false positive or irreproducible results when imputing data with five differe

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WILSON, NICOLA, and SOREN PEDERSEN. "Inflammatory Markers in Clinical Practice." American Journal of Respiratory and Critical Care Medicine 162, supplement_1 (2000): S48—S51. http://dx.doi.org/10.1164/ajrccm.162.supplement_1.maic-13.

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MARTINEZ, FERNANDO D. "Context Dependency of Markers of Disease." American Journal of Respiratory and Critical Care Medicine 162, supplement_1 (2000): S56—S57. http://dx.doi.org/10.1164/ajrccm.162.supplement_1.maic-15.

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Baloch, Zubair W., and Virginia A. LiVolsi. "The Quest for a Magic Tumor Marker." American Journal of Clinical Pathology 118, no. 2 (2002): 165–66. http://dx.doi.org/10.1309/ceaq-vrfw-fjbq-am5m.

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Lahad, J. P. "Stem cell-ness: a "magic marker" for cancer." Journal of Clinical Investigation 115, no. 6 (2005): 1463–67. http://dx.doi.org/10.1172/jci25455.

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Lahad, J. P. "Stem cell-ness: a "magic marker" for cancer." Journal of Clinical Investigation 115, no. 8 (2005): 2298. http://dx.doi.org/10.1172/jci25455e1.

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Sun, Yiming, Yutong Xue, Ruoyang Shao, et al. "Signifcance of Intestinal CD8+CD69+CD103+ Tissue-Resident Memory T Cells in Human Intestinal Acute Graft-Versus-Host Disease." Blood 144, Supplement 1 (2024): 4897. https://doi.org/10.1182/blood-2024-202219.

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Background: Gastrointestinal acute graft-versus-host disease (aGVHD) is a serious complication and a leading cause of mortality following allogeneic hematopoietic stem cell transplantation (allo-HSCT). Recently, tissue-resident memory T cells (TRM) cells in tissue-specific immune and inflammatory diseases is beginning to be appreciated. However, CD8+TRM cells have not been fully elucidated regarding their changes and functions in human intestinal aGVHD. In this study, we used CD69 and CD103 as surrogate markers of human CD8+TRM cells.We performed functional analyses of CD8+TRM cells to explore

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