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Journal articles on the topic 'Magnesium stearate and micro crystalline cellulose'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

NIKAM, BHARAT ASHOK, and AMOL U. GAYKE. "FORMULATION DEVELOPMENT AND EVALUATION OF IMMEDIATE RELEASE TABLET OF PARACETAMOL AND ORPHENADRINE CITRATE BY DIRECT COMPRESSION METHOD." Journal of Science and Arts 22, no. 3 (2022): 735–54. http://dx.doi.org/10.46939/j.sci.arts-22.3-b04.

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The objective of this research work was to formulate, develop and evaluate immediate release tablet of paracetamol and orphenadrine citrate by direct compression method. Paracetamol which is antipyretic and orphenadrine citrate is skeletal muscle relaxant. The drug paracetamol and orphenadrine citrate was taken and formulated with different concentration of cross-povidone, mannitol, micro-crystalline cellulose, magnesium stearate and talc. Where cross-povidone as a superdisintegrant, mannitol as diluent, micro-crystalline cellulose as binder, magnesium stearate as lubricant and talc as a glida

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Staniforth, J. N., and H. A. Ahmed. "INFLUENCE OF TERNARY COMPONENTS ON COMPRESSIBILITY OF MICRO-CRYSTALLINE CELLULOSE FOLLOWING BLENDING WITH MAGNESIUM STEARATE." Journal of Pharmacy and Pharmacology 38, S12 (1986): 50P. http://dx.doi.org/10.1111/j.2042-7158.1986.tb14279.x.

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3

Rangu, Nirmala, and Gande Suresh. "Formulation and Evaluation of Nelfinavir Extended Release Trilayer Matrix Tablets by Design of Experiment." International Journal of Pharmaceutical Sciences and Nanotechnology 11, no. 5 (2018): 4259–68. http://dx.doi.org/10.37285/ijpsn.2018.11.5.6.

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The present study was aimed to develop once-daily controlled release trilayer matrix tablets of nelfinavir to achieve zero-order drug release for sustained plasma concentration. Nelfinavir trilayer matrix tablets were prepared by direct compression method and consisted of middle active layer with different grades of hydroxypropyl methylcellulose (HPMC), PVP (Polyvinyl Pyrrolidine) K-30 and MCC (Micro Crystalline Cellulose). Barrier layers were prepared with Polyox WSR-303, Xanthan gum, microcrystalline cellulose and magnesium stearate. Based on the evaluation parameters, drug dissolution profi

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4

Upadhyay, Uma, and KS Rathore. "FORMULATION AND EVALUATION OF SUSTAINED RELEASE MATRIX TABLETS OF METFORMIN HYDROCHLORIDE." Pharmaceutical and Chemical Journal 1, no. 2 (2014): 5–13. https://doi.org/10.5281/zenodo.13691319.

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The aim of the current study is to design a sustained release matrix tablet of metformin HCl to maintain plasma level of drug for prolong period of time. Metformin HCl is antihyperglycemic agent used in the treatment of type II Non insulin dependent diabetes mellitus. Sustained release formulation of metformin HCl prolong drug absorption in the upper GI tract and permits once daily dosing in patient with type II diabetes mellitus. This newer formulation may enhance patient compliance compared to conventional immediate release metformin HCl. Metformin HCl present significant challenges due to i

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Megha, Pandey* Dr. Shilpa Gawande Dr. A. V. Chandewar. "Formulation And Development of Oral Fast Dissolving Tablets Using a Model Drug." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 3892–905. https://doi.org/10.5281/zenodo.15493439.

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The aim of this study was to develop fast dissolving tablets of cinnarizine by direct compression method. Micro crystalline cellulose (MCC) as diluent and super disintegrants, such as Crospovidone (CP), Cinnarizine(drug), Magnesium Stearate,Talc,Mannitol and croscarmellose Sodium were used. Fast dissolving tablets disintegrates or dissolves rapidly within few seconds due to maximized pore structure in the formulation or by the action of superdisintegrants. Infrared (IR) spectroscopy was performed to identify the physicochemical interaction between drug and polymer. IR spectroscopy showed that

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6

E., Sathish Reddy Meesala. Srinivasa Rao and Mohammed Ibrahim. "FORMULATION AND IN VITRO, IN VIVO EVALUATION OF CEFADROXIL CONTROLLED GASTRORETENTIVE DRUG DELIVERY SYSTEM." Indo American Journal of Pharmaceutical Sciences 04, no. 07 (2017): 2139–50. https://doi.org/10.5281/zenodo.836461.

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Introduction: Cefadroxil is a first-generation cephalosporin and is very effective against Gram positive and Gram negative infections. Cefadroxil is an antibiotic agent which has high absorption in the upper part of the gastrointestinal tract (GIT). Conventional Cefadroxil tablets produce rapid and relatively high peak blood level and require frequent administration to keep the plasma drug level at an effective range. The present study was carried out with an objective of preparation and in vivo evaluation of floating tablets of using Cefadroxil as a model drug using Eudragit polymers to impro

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7

Simran, Tanwar, Tikariya Komal, and Sharma Vimukta. "Formulation and Evaluation of Sustained Release Matrix Tablet of Nimesulide Using Pomegranate Peel and Acacia." International Journal of Pharmaceutical Sciences and Medicine 7, no. 7 (2022): 11–24. http://dx.doi.org/10.47760/ijpsm.2022.v07i07.002.

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The main objective of the study is the formulation and evaluation of sustained release matrix tablet of Nimesulide using pomegranate peel and acacia as natural polymer. The preformulation study of Nimesulide was conducted and λmax was found at 300 nm. The sustained release matrix tablet was prepared using Pomegranate peel as Release rate retardant, Acacia as polymer, Polyvinylpyrrolidone K30 as Binder, Isopropyl alcohol as Granulation solution, Micro Crystalline Cellulose as Diluent, Magnesium stearate as Lubricant and Talc as Glidant. Several formulations were prepared by taking different dru

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8

Li, Yu, Xiangwen Kong, and Fan Hu. "Crystal Transition and Drug-excipient Compatibility of Clarithromycin in Sustained Release Tablets." Current Pharmaceutical Analysis 16, no. 7 (2020): 950–59. http://dx.doi.org/10.2174/1573412915666190328234326.

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Background: Clarithromycin is widely used for infections of helicobacter pylori. Clarithromycin belongs to polymorphic drug. Crystalline state changes of clarithromycin in sustained release tablets were found. Objective: The aim of this study was to find the influential factor of the crystal transition of clarithromycin in preparation process of sustained-release tablets and to investigate the possible interactions between the clarithromycin and pharmaceutical excipients. Methods and Results: The crystal transition of active pharmaceuticals ingredients from form II to form I in portion in clar

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9

Le, Minh-Quan, Khuong-Nhi Cao-Nguyen, Kieu-Trinh Nguyen-Tran, Van-Ha Nguyen, and Hau Le. "Influence of formulation and punch properties on sticking in the tableting process." MedPharmRes 9, no. 1 (2025): 121–33. https://doi.org/10.32895/ump.mpr.9.1.11.

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Punch sticking is a common phenomenon in tablet manufacturing, often leading to tablet defects and compromise product quality. A thorough understanding of the sticking mechanism is essential to optimize the tablet production process. The aim of this study was to investigate the influence of formulations and punch properties on sticking. Seven model active pharmaceutical ingredients (APIs) (i.e., ibuprofen, aspirin, paracetamol, metronidazole, diltiazem, diclofenac, and cefuroxime) with various melting points and particle sizes were used to evaluate their propensity for sticking. The APIs stuck

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10

Salazar-Barrantes, Karen Andrea, Ariadna Abdala-Saiz, José Roberto Vega-Baudrit, Mirtha Navarro-Hoyos, and Andrea Mariela Araya-Sibaja. "Formulation and evaluation of atorvastatin calcium trihydrate Form I tablets." PLOS ONE 20, no. 2 (2025): e0317407. https://doi.org/10.1371/journal.pone.0317407.

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Solid forms transformations and new crystal structures of an active pharmaceutical ingredient (API) can occur due to various manufacturing process conditions, especially if the drug substance is formulated as a hydrate. The conversion between hydrate and anhydrate forms caused by changes in temperature and humidity must be evaluated because of the risk of dehydration and phase transitions during the manufacturing process. Differences in physicochemical, mechanical, and rheological properties have been observed between solid forms of the same API that can cause manufacturing and product-related

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11

"Formulation and Evaluation of Sustained Release Matrix Tablet of Itopride." American Journal of PharmTech Research 11, no. 5 (2021). http://dx.doi.org/10.46624/ajptr.2021.v11.i5.008.

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The objective of this research work was to carry out design and evaluation of sustained release matrix tablets of Itopride by use of natural and synthetic polymers. Matrix tablets were prepared by wet granulation technique by using natural polymers like Carbopol 934, Tamarind poly saccharide, Locust bean gum, Ethyl cellulose, HPMC K 100 as matrix forming agent and excipients such as Lactose, Starch 1500, Magnesium stearate, MCC and talc were used. The dissolution medium consisted of 900 ml of 0.1 N HCl for first 2 hours and then 7.4 phosphate buffer for remaining 10 hours. The release of Itopr

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12

Nath, Bipul, and Tushar Roy. "Compatibility Studies of Atorvastatin Calcium with Selected Excipients By Means of Thermal and FT-IR Spectroscopic Methods for the Development of Immediate Release Tablet." International Journal of Pharmaceutical Sciences and Drug Research 8, no. 03 (2016). http://dx.doi.org/10.25004/ijpsdr.2016.080310.

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The objectives of present investigation is to evaluate the compatibility of Atorvastatin calcium with immediate release excipients and to optimize the tablet which release is best comparable with innovator product by varying different super disintegrants. Various excipients used were sodium starch glycollate, cross carmellose sodium, cross-povidone, lactose, micro crystalline cellulose, mannitol, sodium lauryl sulfate, magnesium stearate, and stearic acid. Thermal characterization of the drug was done by DSC and FT-IR. From the DSC studies, the excipients such as microcrystalline cellulose (Av

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13

Gangavarapu, Nadia Psalms* Shilpa Allabotharam Dr.Khaja Zeeyauddin Shaik Ejas. "FORMULATION AND EVALUATION OF FLOATING TABLET OF ALFUZOSIN HCL." December 3, 2022. https://doi.org/10.5281/zenodo.7393008.

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<em>The present work was to prepare and optimized floating tablet of Alfuzosin HCl. Alfuzosin HCl is an alfa-1 adrenergic receptor blocker for the treatment of benign prostatic hyper pleasia & hypertension which are design to increase the gastric residence time, thus prolonging the drug release. Alfuzosin HCL has the short biological half -life (3-5hrs) the dose may range from 2.5mg thrice a day to maximum of 10mg once a day which results into inconveniency to the patients. By preparing the floating tablets of Alfuzosin HCl that deliver the drug for longer time, reduced dosage frequency &a

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14

CH, Kantharao, Swarna K, and Leelakrishna J. "Diclofenac Orodispersible Tablets: Formulation and In Vitro Evaluation." Annals of Clinical and Laboratory Research, February 13, 2019. https://doi.org/10.5281/zenodo.8256036.

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<strong>Aim: </strong>The aim of the present study is to prepare and evaluate Diclofenac sodium orodispresible tablets by using two super disintegrates, such as croscarmellose sodium (CCS) and sodium starch glycolate (SSG) in different concentrations by using direct compression technique. <strong>Materials and methods: </strong>We prepared 8 formulations by using direct compression technique. For this preparation, we have used different excipients along with the Dicofenac sodium drug such as sodium starch glycolate, carboxy methyl cellulose, lactose, mannitol, croscarmellose sodium,

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15

Nandam, Uma Maheswara Subbarao* Mrs. Raj Khiani Mrs M.Vineela. "FORMULATION AND INVITRO EVALUATION OF EFFERVESCENT FLOATING TABLETS OF DOMPERIDONE." August 1, 2023. https://doi.org/10.5281/zenodo.8206304.

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<em>The present study was aimed to formulate and evaluate floating tablets of Domperidone by direct compression method. Domperidone is a dopamine antagonist medication which is used to treat nausea and vomiting and certain gastrointestinal problems like gastroparesis (delayed gastric emptying). In this study, excipients like Eudragit RSPO, </em><em>HPMC, Carbopol 974P,</em><em> sodium bicarbonate and </em><em>Citric acid</em><em> were incorporated in a nine different concentrations (F1-F9) along with other excipients (Magnesium Stearate, Talc and Micro crystalline cellulose) to formulate float

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16

*Ezegbe, Chekwube Andrew Ezegbe Amarachi Grace Chime Amarachi Salome Ugwu Calister Elochukwu Boniface Christian Izuchukwu Ugwuoke Kenneth Ejiofor Chukwuemeka Chizoba Lorritaa Onunkwo Godswill. "MOISTURE ACTIVATED DRY GRANULATION (MADG)." March 20, 2023. https://doi.org/10.5281/zenodo.7754894.

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<strong><em>Introduction: </em></strong><em>Metronidazole is a synthetic oral nitroimidazole antibiotic used in the treatment of infections caused by anaerobic bacteria and protozoa. It also has amebicidal and antiprotozoal properties.</em> <strong><em>Aim</em></strong><em>: The purpose of the study was to formulate and evaluate metronidazole tablets formulated with polymers (PVP and PEG) and maize starch as disintegrant using moisture activated dry granulation (MADG). </em> <strong><em>Method</em></strong><em>: Twenty-four (24) batches of metronidazole granules and tablets were prepared by mo

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17

Andrew, Ezegbe Chekwube, Ezegbe Amarachi Grace, Chime Amarachi Salome, et al. "EVALUATION OF METRONIDAZOLE TABLETS FORMULATED WITH DIFFERENT DISINTEGRANTS USING MOISTURE ACTIVATED DRY GRANULATION." Universal Journal of Pharmaceutical Research, July 15, 2023. http://dx.doi.org/10.22270/ujpr.v8i3.951.

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Introduction: Metronidazole is a synthetic oral nitroimidazole antibiotic used in the treatment of infections caused by anaerobic bacteria and protozoa. It also has amebicidal and antiprotozoal properties. Aim: The purpose of the study was to formulate and evaluate metronidazole tablets formulated with polymers (PVP and PEG) and maize starch as disintegrant using moisture activated dry granulation (MADG). Method: Twenty-four (24) batches of metronidazole granules and tablets were prepared by moisture activated dry granulation. Metronidazole (200 mg), lactose and gelatin (1, 2, 4, and 8 %) were

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18

Vantimita, Sarovar Reddy, and S. Jeganath. "Formulation and evaluation of gastroretentive drug delivery system of eprosartanmesylate." International journal of health sciences, April 2, 2022, 2914–26. http://dx.doi.org/10.53730/ijhs.v6ns1.5364.

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It had became a challenging experience and effort for a formulator to develop and innovate a drug with maximum bioavailability. Objective: In the present study the focus of research is in the treatment of Hypertension, which is one of the most prevalent cardiovascular diseases in the world, affecting a big proportion of the adult and old age population. Eprosartan mesylate(EPM) is angiotensin-II receptor antagonist used for the treatment of high blood pressure. The drug has poor bioavailability due to limited oral absorption and maximum absorption at proximal intestine. This warrants and offer

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19

Alterary, Seham S., Gamal A. E. Mostafa, Maha F. El‐Tohamy, and Haitham AlRabia. "New Enhancement Spectrofluorimetric Determination of Anti‐Breast Cancer Drugs Palbociclib by Biogenic‐Synthesized Alumina/NiO Nanocomposite." ChemistrySelect 9, no. 10 (2024). http://dx.doi.org/10.1002/slct.202304586.

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AbstractThis study is based on green synthesized nanomaterials that increase fluorescence intensity in the study of the anticancer drug palbociclib. The basis for the nanomaterials was the use of alumina/nickel oxide nanocomposite (alumina/NiO NCS) biogenically produced from millet seed extract. The proposed materials improved the spectrofluorimetric method for the study of the breast cancer drug palbociclib (PAL) in its real powder and capsules. The amplification properties of the developed spectrofluorimetric system depend on the unique optical properties of the alumina/NiO NCS. Fluorescence

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20

Nadendla, Rama Rao, Prachet Pinnamaneni, Siva Prasad Morla, and Patchala Abhinandana. "Physico-Chemical Characterization of Paliperidone Palmitate and Compatibility Studies with its Pharmaceutical Excipients." Journal of Pharmaceutical Research International, March 1, 2021, 85–91. http://dx.doi.org/10.9734/jpri/2021/v33i531183.

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Aim: The main aim of the present study was to characterize and perform the compatibility studies of paliperidone with its excipients. Study Design: Physico-chemical characterization and compatibility studies. Place and Duration of the Study: Chalapathi Drug Testing Laboratory, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur-522034 between December 2020 and January 2021. Methodology: Physico-chemical characterization and compatibility studies of paliperidone palmitate with its excipients like HPMC, lactose, magnesium stearate, talc, microcrystall

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21

K Pavani, Kondabala Bhavya sri, Barkam Mamatha, et al. "FORMULATION AND EVALUATION OF CLINDAMYCIN HYDROCHLORIDE FLOATING DRUG DELIVERY." EPRA International Journal of Multidisciplinary Research (IJMR), April 14, 2024, 280–91. http://dx.doi.org/10.36713/epra16414.

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The Clindamycin Hydrochloride is a broad spectrum cephalosporin antibiotic. It is mainly used to treatment of bacterial infections. It is a suitable candidate for controlled release administration due to its short elimination time 1 hours. The main aim of present investigation is to increase the gastric residence time by preparing floating drug delivery by using raft forming approach thereby improving bioavailability. The prepared Clindamycin Hydrochloride floating drug delivery were evaluated for hardness, weight variation, thickness, friability, drug content uniformity, total floating time,

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22

Maddiboyina, Balaji, Vikas Jhawat, Gandhi Sivaraman, et al. "Formulation Development and Characterization of controlled release core in cup matrix tablets of venlafaxine HCl." Current Drug Therapy 15 (March 31, 2020). http://dx.doi.org/10.2174/1574885515666200331104440.

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Background: Venlafaxine HCl is a selective serotonin reuptake inhibitor which is given in the treatment of depression. The delivery of the drug at a controlled rate can be of great importance for prolonged effect. Objective: The objective was to prepare and optimize the controlled release core in cup matrix tablet of venlafaxine HCl using the combination of hydrophilic and hydrophobic polymers to prolong the effect with rate controlled drug release. Methods: The controlled release core in cup matrix tablets of venlafaxine HCl were prepared using HPMC K5, K4, K15, HCO, IPA, aerosol, magnesium s

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