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Journal articles on the topic 'Magnetic dual-modal probes'

Author: Grafiati

Published: 8 June 2024

Last updated: 31 July 2025

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1

Chen, Bing Di, Tian Zhou, Bo Zhang, and Ai Hua Yao. "Novel Single Walled Carbon Nanotube Based Magnetic-Fluorescent Nanohybrids as Dual-Modal MRI/Optical Imaging Probes." Advanced Materials Research 476-478 (February 2012): 1134–37. http://dx.doi.org/10.4028/www.scientific.net/amr.476-478.1134.

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Gadolinium chelate and Quantum Dots (QDs) decorated single walled carbon nanotubes (SWNTs) nanohybrids (SWNT-Gd-QDs) were designed for dual-modal cellular imaging via magnetic resonance imaging (MRI) and optical imaging. The nanohybrids were prepared via a simple and novel layer-by-layer (LBL) assembly in combination with covalent connection strategy. The SWNT-Gd-QDs nanohybrids showed a strong near-infrared photoluminescence (PL) emission at room temperature and enhanced T1-weighted and T2-weighted MRI signals in water. Thus, the nanohybrids combine magnetic and fluorescent properties and can

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2

Zhu, Qin, Fei Pan, Yu Tian, Weijun Tang, Yuan Yuan, and Aiguo Hu. "Facile synthesis of Gd(iii) metallosurfactant-functionalized carbon nanodots with high relaxivity as bimodal imaging probes." RSC Advances 6, no. 35 (2016): 29441–47. http://dx.doi.org/10.1039/c6ra02654k.

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3

Liu, Ping, and Wei Miu. "Hydrothermal synthesis of BaYbF5:Tm3+ nanoparticles for dual-modal upconversion near-infrared luminescence and magnetic resonance imaging." Functional Materials Letters 09, no. 03 (2016): 1650038. http://dx.doi.org/10.1142/s1793604716500387.

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In this paper, we demonstrate multifunctional upconversion nanoparticles with intense near-infrared emission and unique magnetic properties for dual-modal upconversion luminescent bioimaging and T2-weighted magnetic resonance imaging. High-quality BaYbF5:Tm3+ nanoparticles are synthesized via a hydrophobic method and then converted to be hydrophilic via a hydrochloric acid treatment. The as-synthesized nanoparticles are cubic phase and about 6 nm in diameter with narrow size distribution. The intense near-infrared emission makes these nanoparticles can be acted as bio-probes in upconversion lu

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4

Stasiuk, Graeme J., Florencia Minuzzi, Myra Sae-Heng та ін. "Dual-Modal Magnetic Resonance/Fluorescent Zinc Probes for Pancreatic β-Cell Mass Imaging". Chemistry - A European Journal 21, № 13 (2015): 5023–33. http://dx.doi.org/10.1002/chem.201406008.

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5

Gao, Ai, Dan Zhang, and Xue-Bo Yin. "Near infrared fluorescence-magnetic resonance dual-modal imaging with Cy5-labeled, Gd–Al co-doped mesoporous silica nanoparticles." Analytical Methods 8, no. 1 (2016): 214–21. http://dx.doi.org/10.1039/c5ay02230d.

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We report a reliable and facile procedure to prepare near infrared fluorescence (NIRF)-magnetic resonance dual-modal imaging probes (DMIPs) using Cy5-labeled, Gd–Al co-doped mesoporous silica nanoparticles. High intensity NIRF and a relaxation rate (17.7 mM<sup>−1</sup>s<sup>−1</sup>) can be observed. Furthermore, the DMIPs in saline were injected into mice through the tail vein for imaging.

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6

Fei-Peng, Zhu, Chen Guo-Tao, Wang Shou-Ju, et al. "Dual-Modality Imaging Probes with High Magnetic Relaxivity and Near-Infrared Fluorescence Based Highly Aminated Mesoporous Silica Nanoparticles." Journal of Nanomaterials 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/6502127.

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Dual-modal imaging by combining magnetic resonance (MR) and near-infrared (NIR) fluorescence can integrate the advantages of high-resolution anatomical imaging with high sensitivity in vivo fluorescent imaging, which is expected to play a significant role in biomedical researches. Here we report a dual-modality imaging probe (NIR/MR-MSNs) fabricated by conjugating NIR fluorescent heptamethine dyes (IR-808) and MR contrast agents (Gd-DTPA) within highly aminated mesoporous silica nanoparticles (MSNs-NH2). The dual-modality imaging probes NIR/MR-MSNs possess a size of ca. 120 nm. The NIR/MR-MSNs

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7

Li, Dongdong, Wenzhi Song, Dezhou Wang, Shengyang Qi, Kaishen Li, and Wanzhong Yin. "AIEgens functionalized gadolinium-based aminoclay as dual-modal probes for fluorescence and magnetic resonance imaging." Inorganic Chemistry Communications 95 (September 2018): 32–35. http://dx.doi.org/10.1016/j.inoche.2018.07.003.

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8

Li, Kai, Dan Ding, Da Huo, et al. "Conjugated Polymer Based Nanoparticles as Dual-Modal Probes for Targeted In Vivo Fluorescence and Magnetic Resonance Imaging." Advanced Functional Materials 22, no. 15 (2012): 3107–15. http://dx.doi.org/10.1002/adfm.201102234.

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9

Liu, Chunyan, Zhenyu Gao, Jianfeng Zeng, et al. "Magnetic/Upconversion Fluorescent NaGdF4:Yb,Er Nanoparticle-Based Dual-Modal Molecular Probes for Imaging Tiny Tumors in Vivo." ACS Nano 7, no. 8 (2013): 7227–40. http://dx.doi.org/10.1021/nn4030898.

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10

Baziulyte-Paulaviciene, Dovile, Vitalijus Karabanovas, Marius Stasys, et al. "Synthesis and functionalization of NaGdF4:Yb,Er@NaGdF4 core–shell nanoparticles for possible application as multimodal contrast agents." Beilstein Journal of Nanotechnology 8 (September 1, 2017): 1815–24. http://dx.doi.org/10.3762/bjnano.8.183.

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Upconverting nanoparticles (UCNPs) are promising, new imaging probes capable of serving as multimodal contrast agents. In this study, monodisperse and ultrasmall core and core–shell UCNPs were synthesized via a thermal decomposition method. Furthermore, it was shown that the epitaxial growth of a NaGdF4 optical inert layer covering the NaGdF4:Yb,Er core effectively minimizes surface quenching due to the spatial isolation of the core from the surroundings. The mean diameter of the synthesized core and core–shell nanoparticles was ≈8 and ≈16 nm, respectively. Hydrophobic UCNPs were converted int

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11

Ostruszka, Radek, Aminadav Halili, Tomas Pluhacek, Lucie Rarova, Daniel Jirak, and Karolina Siskova. "Advanced protein-embedded bimetallic nanocomposite optimized for in vivo fluorescence and magnetic resonance bimodal imaging." Journal of colloid and interface science 663, June 2024 (2024): 467–77. https://doi.org/10.1016/j.jcis.2024.02.116.

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Hypothesis: The development of bimodal imaging probes represents a hot topic of current research. Herein, we deal with developing an innovative bimodal contrast agent enabling fluorescence imaging (FI)/magnetic resonance imaging (MRI) and, simultaneously, consisting of biocompatible nanostructures. Optimized synthesis of advanced protein-embedded bimetallic (APEBM) nanocomposite containing luminescent gold nanoclusters (AuNC) and superparamagnetic iron oxide nanoparticles (SPION), suitable for in vivo dual-modal FI/MR imaging is reported. Experiments: The APEBM nanocomposite was prepared by a

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12

Marasini, Shanti, Huan Yue, Adibehalsadat Ghazanfari, et al. "Polyaspartic Acid-Coated Paramagnetic Gadolinium Oxide Nanoparticles as a Dual-Modal T1 and T2 Magnetic Resonance Imaging Contrast Agent." Applied Sciences 11, no. 17 (2021): 8222. http://dx.doi.org/10.3390/app11178222.

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Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd2O3 nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r1 and r2 of 19.1 and = 53.7 s−1mM−1, respectively, (r1 and r2 are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those

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13

Zhao, Runge, Deren Lan, Beibei Xia, MengJie Dong, Jing Mu, and Yongsheng Zhao. "PET‐Based Dual‐Modal Probes for In Vivo Imaging." Small, January 28, 2025. https://doi.org/10.1002/smll.202409713.

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AbstractMolecular imaging has significantly advanced the detection and analysis of in vivo metabolic processes, while single‐modal techniques remain limited. Dual‐modal imaging, particularly positron emission tomography (PET)‐based combinations has emerged as a powerful solution, offering enhanced capabilities through integration with magnetic resonance imaging (MRI) or near‐infrared fluorescence (NIRF) imaging. This review highlights recent progress in PET‐based dual‐modal imaging, focusing on the development of various bimodal probes derived from antibodies, nanoparticles, and peptides, and

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14

Xie, Ruoxi, Zijun Wu, Fanxin Zeng, et al. "Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma." Signal Transduction and Targeted Therapy 6, no. 1 (2021). http://dx.doi.org/10.1038/s41392-021-00724-y.

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AbstractGlioblastoma (GBM), one of the most common primary intracranial malignant tumours, is very difficult to be completely excised by surgery due to its irregular shape. Here, we use an MRI/NIR fluorescence dual-modal imaging nanoprobe that includes superparamagnetic iron oxide nanoparticles (SPIONs) modified with indocyanine (Cy7) molecules and peptides (ANG or DANG) to locate malignant gliomas and guide accurate excision. Both peptides/Cy7-SPIONs probes displayed excellent tumour-homing properties and barrier penetrating abilities in vitro, and both could mediate precise aggregation of th

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15

Nakanishi, Yusuke, Masataka Nagata, Hirotoshi Yasui, and Kazuhide Sato. "Gd-Encapsulated Carbon Nanotubes as Dual-Modal Probes for Magnetic Resonance and Second Near-Infrared Emission." ECS Journal of Solid State Science and Technology, August 31, 2022. http://dx.doi.org/10.1149/2162-8777/ac8e2f.

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Abstract We report a near-infrared (NIR) fluorescence and magnetic resonance (MR) dual-modal probe composed of fluorescent carbon nanotubes (CNTs) filled with paramagnetic Gd ions. The Gd-filled CNTs are synthesized by means of a vapor-phase technique using gadolinium halides as precursors, and host CNTs exhibit the strong photoluminescence even after Gd filling. We have investigated the NIR fluorescence and MR imaging in vivo as well as in vitro, and demonstrated that the Gd-filled CNTs can be used for the dual-modal imaging of tissues and vessels in the living mice.

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16

Maria, Elena Materia, Pernia Leal Manuel, Scotto Marco, et al. "Multifunctional Magnetic and Upconverting Nanobeads as Dual Modal Imaging Tools." March 15, 2021. https://doi.org/10.1021/acs.bioconjchem.7b00432.

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We report the fabrication of aqueous multimodal imaging nanocomposites based on superparamagnetic nanoparticles (MNPs) and two different sizes of photoluminescent upconverting nanoparticles (UCNPs). The controlled and simultaneous incorporation of both types of nanoparticles (NPs) was obtained by controlling the solvent composition and the addition rate of the destabilizing solvent. The magnetic properties of the MNPs remained unaltered after their encapsulation into the polymeric beads as shown by the T2 relaxivity measurements. The UCNPs maintain photoluminescent properties even when embedde

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17

Dong, Yansong, Ye Liu, Yalan Tu, Youyong Yuan, and Jun Wang. "AIEgens Cross‐Linked Iron Oxide Nanoparticles Synchronously Amplify Bimodal Imaging Signals in Situ by Tumor Acidity‐Mediated Click Reaction." Angewandte Chemie International Edition, November 11, 2023. http://dx.doi.org/10.1002/anie.202310975.

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Activatable dual‐modal molecular imaging probes present a promising tool for the diagnosis of malignant tumors. However, synchronously enhancing dual‐modal imaging signals under a single stimulus is challenging. Herein, we propose an activatable bimodal probe that integrates aggregation‐induced emission luminogens (AIEgens) and iron oxide nanoparticles (IOs) to synergistically enhance near‐infrared fluorescence (NIRF) intensity and magnetic resonance (MR) contrast through a tumor acidity‐mediated click reaction. Tumor acidity‐responsive IOs containing dibenzocyclooctyne groups (termed cDIOs) a

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18

Dong, Yansong, Ye Liu, Yalan Tu, Youyong Yuan, and Jun Wang. "AIEgens Cross‐Linked Iron Oxide Nanoparticles Synchronously Amplify Bimodal Imaging Signals in Situ by Tumor Acidity‐Mediated Click Reaction." Angewandte Chemie, November 11, 2023. http://dx.doi.org/10.1002/ange.202310975.

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Activatable dual‐modal molecular imaging probes present a promising tool for the diagnosis of malignant tumors. However, synchronously enhancing dual‐modal imaging signals under a single stimulus is challenging. Herein, we propose an activatable bimodal probe that integrates aggregation‐induced emission luminogens (AIEgens) and iron oxide nanoparticles (IOs) to synergistically enhance near‐infrared fluorescence (NIRF) intensity and magnetic resonance (MR) contrast through a tumor acidity‐mediated click reaction. Tumor acidity‐responsive IOs containing dibenzocyclooctyne groups (termed cDIOs) a

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19

Yu, Cheng, Zhuyuan Ding, Huan Liu, et al. "Novel albumin-binding multifunctional probe for synergistic enhancement of FL/MR dual-modal imaging and photothermal therapy." Frontiers in Chemistry 11 (August 1, 2023). http://dx.doi.org/10.3389/fchem.2023.1253379.

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The fluorescence/magnetic resonance (FL/MR) dual-modal imaging could provide accurate tumor visualization to guide photothermal therapy (PTT) of cancer, which has attracted widespread attention from scientists. However, facile and effective strategies to synergistically enhance fluorescence intensity, MR contrast and photothermal efficacy have rarely been reported. This study presents a novel multifunctional probe Gd-EB-ICG (GI) for FL/MR dual-modal imaging-guided PTT of cancer. GIs can self-assemble with endogenous albumin to form drug-albumin complexes (GIAs), which exhibit excellent biocomp

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20

Zhang, Ya’nan, Lu Liu, Wenling Li, et al. "PDGFB-targeted functional MRI nanoswitch for activatable T1–T2 dual-modal ultra-sensitive diagnosis of cancer." Journal of Nanobiotechnology 21, no. 1 (2023). http://dx.doi.org/10.1186/s12951-023-01769-7.

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AbstractAs one of the most significant imaging modalities currently available, magnetic resonance imaging (MRI) has been extensively utilized for clinically accurate cancer diagnosis. However, low signal-to-noise ratio (SNR) and low specificity for tumors continue to pose significant challenges. Inspired by the distance-dependent magnetic resonance tuning (MRET) phenomenon, the tumor microenvironment (TME)-activated off–on T1–T2 dual-mode MRI nanoswitch is presented in the current study to realize the sensitive early diagnosis of tumors. The tumor-specific nanoswitch is designed and manufactur

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21

Wen, Yu, Ruoxuan Liu, Yangcenzi Xie, Xinyu Liu, and Ming Li. "SERS surgical navigation with postsurgical immunotherapy of local microtumors and distant metastases for improved anticancer outcomes." Science Advances 10, no. 33 (2024). http://dx.doi.org/10.1126/sciadv.ado2741.

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The standard of clinical care of most malignant solid cancers is surgery, followed by postsurgical adjuvant therapy, but microtumor lesions left behind after surgery and invisible distant metastases are the major reasons for treatment failure. Here, we report an integrated strategy combining surface-enhanced Raman spectroscopy (SERS) surgical navigation with postsurgical immunotherapy elicited by near-infrared II photothermal treatment and programmed death-1 antibody. The SERS surgical navigation is principally based on the multifunctional optical probes (namely, MATRA probes) integrating with

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22

Yang, Yanling, Xiaoming Hu, Zhen Yang, and Wei Huang. "Insights into Molecular Lanthanide Complexes: Construction, Properties and Bioimaging and Biosensing Applications." Advanced Functional Materials, September 12, 2024. http://dx.doi.org/10.1002/adfm.202412970.

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AbstractThe lanthanide complex, characterized by narrow emission bands, large Stokes shifts, long luminescence lifetime, robust resistance to photobleaching, and magnetic properties, affords significant promise for molecular imaging and biosensing applications. While most lanthanide complexes emitting visible light are extensively studied for cellular‐level detection and bioimaging, near‐infrared‐emitted (700–1700 nm) lanthanide compounds exhibit more favorable properties for bioimaging and biosensing, ascribed from deeper penetration and reduced bleaching effects. Besides, the magnetic lantha

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23

Huang, Rui, Yi Zhou, Jiaxiang Hu, An Peng, and Weihao Hu. "Deep learning-assisted multicolor fluorescent probes for Image and Spectral dual-modal identification of illicit drugs." Sensors and Actuators B: Chemical, July 2023, 134348. http://dx.doi.org/10.1016/j.snb.2023.134348.

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24

Wang, Shuhan, Xuan Zhang, Yiping Zhang, et al. "Activatable Nanoprobes for Dual‐Modal NIR‐II Photoacoustic and Fluorescence Imaging of Hydrogen Sulfide in Colon Cancer." Advanced Optical Materials, December 26, 2023. http://dx.doi.org/10.1002/adom.202302796.

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AbstractHigh hydrogen sulfide (H2S) expression has been shown to play a crucial role in tumor growth and proliferation in colon cancer. So far, most probes used for monitoring H2S offer single‐modal imaging, which makes the collection of accurate information for tumor diagnosis difficult. In the present study, a novel dual‐modal imaging probe in the second near‐infrared (NIR‐II, 950‐1700) window is proposed and constructed by coating a uniform shell of polydopamine (PDA) on the surface of cuprous oxide (Cu2O)‐conjugated downconversion nanoparticles (DCNPs). Of note, DCNP‐Cu2O@PDA is in the “on

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25

Wei, Zhuxin, Guangxin Duan, Baoxing Huang, et al. "Rapidly liver-clearable rare-earth core–shell nanoprobe for dual-modal breast cancer imaging in the second near-infrared window." Journal of Nanobiotechnology 19, no. 1 (2021). http://dx.doi.org/10.1186/s12951-021-01112-y.

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Abstract Background Fluorescence imaging as the beacon for optical navigation has wildly developed in preclinical studies due to its prominent advantages, including noninvasiveness and superior temporal resolution. However, the traditional optical methods based on ultraviolet (UV, 200–400 nm) and visible light (Vis, 400–650 nm) limited by their low penetration, signal-to-noise ratio, and high background auto-fluorescence interference. Therefore, the development of near-infrared-II (NIR-II 1000–1700 nm) nanoprobe attracted significant attentions toward in vivo imaging. Regrettably, most of the

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26

Hao, Jiaqi, Huawei Cai, Lei Gu, et al. "A transferrin receptor targeting dual-modal MR/NIR fluorescent imaging probe for glioblastoma diagnosis." Regenerative Biomaterials, February 17, 2024. http://dx.doi.org/10.1093/rb/rbae015.

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Abstract The prognosis of glioblastoma (GBM) remains challenging, primarily due to the lack of a precise, effective imaging technique for comprehensively characterization. Addressing GBM diagnostic challenges, our study introduces an innovative dual-modal imaging that merges near-infrared (NIR) fluorescent imaging with magnetic resonance imaging (MRI). This method employs superparamagnetic iron oxide nanoparticles (SPIONs) coated with NIR fluorescent dyes, specifically Cyanine 7 (Cy7), and targeted peptides. This synthetic probe facilitate MRI functionality through SPIONs, provides NIR imaging

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27

Jiang, Xiaoping, Yue Guo, Lixi Wang, and Qitu Zhang. "Dynamic photoluminescent and photochromic properties of CaAl12O19:Eu, Tb: A novel phosphor for advanced dual-modal multicolor anticounterfeiting." Ceramics International, October 2023. http://dx.doi.org/10.1016/j.ceramint.2023.09.325.

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