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Journal articles on the topic 'Magnetic nanoparticles (MNPs)'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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1

Li, Bin, Yuexia Han, Yang Liu, and Fang Yang. "Fine-tuned magnetic nanobubbles for magnetic hyperthermia treatment of glioma cells." Biointerphases 17, no. 6 (2022): 061004. http://dx.doi.org/10.1116/6.0002110.

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Magnetic nanoparticle (MNP) induced magnetic hyperthermia has been demonstrated as a promising technique for the treatment of brain tumor. However, lower heating efficiency resulting from low intratumoral accumulation of magnetic nanomaterials is still one of the significant limitations for their thermotherapeutic efficacy. In this study, we have designed a nanobubble structure with MNPs decorated on the shell, which leads to the improvement of magnetocaloric performance under an alternating magnetic field. First, the phospholipid coupled with MNPs as the shell to be self-assembled magnetic na
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Alsnani, Hind, Manal M. Khowdiary, and Mohamed S. A. Darwish. "The Magnetic Properties and Photoactivity of Bi-Magnetic Nanostructures for Hydrogen Production." Crystals 13, no. 10 (2023): 1527. http://dx.doi.org/10.3390/cryst13101527.

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The major challenge of hydrogen production via photocatalytic water-splitting is to utilize active photocatalysts that respond to a wide range of visible light. In this work, hybrid nanostructures purposed to combine the tunable magnetic behavior of soft/semi-hard magnetic particles have shown advantageous photoactivity. A series of photocatalysts based on ferrite nanoparticles, magnetite nanoparticles (MNPs), cobalt ferrite nanoparticles (CFNPs), magnetite nanoparticles coated on cobalt ferrite nanoparticles (MNPs @ CFNPs), and cobalt ferrite nanoparticles coated on magnetite nanoparticles (C
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3

Hong, Jiaqi, Linhao Wang, Qikai Zheng, Changyu Cai, Xiaohua Yang, and Zhenlin Liao. "The Recent Applications of Magnetic Nanoparticles in Biomedical Fields." Materials 17, no. 12 (2024): 2870. http://dx.doi.org/10.3390/ma17122870.

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Magnetic nanoparticles (MNPs) have found extensive application in the biomedical domain due to their enhanced biocompatibility, minimal toxicity, and strong magnetic responsiveness. MNPs exhibit great potential as nanomaterials in various biomedical applications, including disease detection and cancer therapy. Typically, MNPs consist of a magnetic core surrounded by surface modification coatings, such as inorganic materials, organic molecules, and polymers, forming a nucleoshell structure that mitigates nanoparticle agglomeration and enhances targeting capabilities. Consequently, MNPs exhibit
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Darwish, Mohamed S. A. "Magnetite @ Zinc Cobalt Ferrite Nanoparticles: Synthesis, Magnetic Behavior, and Optical Properties." Crystals 13, no. 8 (2023): 1284. http://dx.doi.org/10.3390/cryst13081284.

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One of the main challenges is using an effective photocatalyst that responds to a broad range of visible light for hydrogen production during water splitting. Series types of photocatalysts based on magnetic ferrite nanostructure were fabricated via a two-step co-precipitation technique. Precisely, four types of magnetic structures: magnetite nanoparticles (MNPs), zinc cobalt ferrite nanoparticles (ZCFNPs), hybrid magnetite/zinc cobalt ferrite nanoparticles (MNPs @ ZCFNPs), and hybrid zinc cobalt ferrite/magnetite nanoparticles (ZCFNPs @ MNPs) were used to fabricate magnetic photocatalysts. Th
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Mannu, Rashmi, Vaithinathan Karthikeyan, Nandakumar Velu, et al. "Polyethylene Glycol Coated Magnetic Nanoparticles: Hybrid Nanofluid Formulation, Properties and Drug Delivery Prospects." Nanomaterials 11, no. 2 (2021): 440. http://dx.doi.org/10.3390/nano11020440.

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Magnetic nanoparticles (MNPs) are widely used materials for biomedical applications owing to their intriguing chemical, biological and magnetic properties. The evolution of MNP based biomedical applications (such as hyperthermia treatment and drug delivery) could be advanced using magnetic nanofluids (MNFs) designed with a biocompatible surface coating strategy. This study presents the first report on the drug loading/release capability of MNF formulated with methoxy polyethylene glycol (referred to as PEG) coated MNP in aqueous (phosphate buffer) fluid. We have selected MNPs (NiFe2O4, CoFe2O4
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Zhang, Kai, Xinlong Song, Meng Liu, Menghua Chen, Jie Li, and Jinglong Han. "Review on the Use of Magnetic Nanoparticles in the Detection of Environmental Pollutants." Water 15, no. 17 (2023): 3077. http://dx.doi.org/10.3390/w15173077.

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Magnetic nanomaterials (MNPs) have been widely used in the detection of pollutants in the environment because of their excellent nano effect and magnetic properties. These intrinsic properties of MNPs have diversified their application in environmental contaminant detection. In this paper, the research status quo of the use of MNPs in detecting organic and inorganic contaminants from wastewater and soil is reviewed. The preparation method and modification technology of magnetic nanoparticles are also described in detail. The application prospect of magnetic nanoparticle composites in the detec
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Bustamante-Torres, Moises, David Romero-Fierro, Jocelyne Estrella-Nuñez, Belén Arcentales-Vera, Estefani Chichande-Proaño, and Emilio Bucio. "Polymeric Composite of Magnetite Iron Oxide Nanoparticles and Their Application in Biomedicine: A Review." Polymers 14, no. 4 (2022): 752. http://dx.doi.org/10.3390/polym14040752.

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A broad spectrum of nanomaterials has been investigated for multiple purposes in recent years. Some of these studied materials are magnetics nanoparticles (MNPs). Iron oxide nanoparticles (IONPs) and superparamagnetic iron oxide nanoparticles (SPIONs) are MNPs that have received extensive attention because of their physicochemical and magnetic properties and their ease of combination with organic or inorganic compounds. Furthermore, the arresting of these MNPs into a cross-linked matrix known as hydrogel has attracted significant interest in the biomedical field. Commonly, MNPs act as a reinfo
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8

Chen, Yingxiu, and Jiasheng Yan. "Synthesis and Verification of a Novel Attainable Tumor Targeting Magnetic Nanoparticle." Acta Poloniae Pharmaceutica - Drug Research 80, no. 5 (2023): 755–62. http://dx.doi.org/10.32383/appdr/173984.

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This study aimed to prepare a novel multifunctional magnetic nanoparticle (MNP) with a drug-loadable encapsulation and a matrix metalloproteinase (MMP) substrate-modified TAT peptide whose transmembrane ability can be activated in an MMP-rich environment, and to evaluate the uptake of this nanoparticle by cells, as well as its cytotoxicity. Nanoparticles were synthesized and modified with TAT or MMPs-TAT peptides. PC-3 cells and RWPE-1 cells were cultured with these nanoparticles at different concentrations, with or without MMP-2 pretreatment, and their uptake rate and toxicity were determined
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9

Zhong, Zihui, Jincan He, Gongke Li, and Ling Xia. "Recent Advances in Magnetic Nanoparticles-Assisted Microfluidic Bioanalysis." Chemosensors 11, no. 3 (2023): 173. http://dx.doi.org/10.3390/chemosensors11030173.

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Magnetic nanoparticles (MNPs) are attracting increasing attention in bioanalysis, due to their large surface area and excellent steerable properties. Meanwhile, the booming development of microfluidics is offering a faster, lower consumption, and more effective approach to bioanalysis. MNPs-assisted microfluidic bioanalysis enables enhanced analytical performance by introducing functionalized magnetic nanomaterial into microchip devices. This work reviews the advances of MNPs-assisted microfluidic bioanalysis in the recent decade. The preparation and modification methods of MNPs are summarized
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Manescu (Paltanea), Veronica, Gheorghe Paltanea, Iulian Antoniac, and Marius Vasilescu. "Magnetic Nanoparticles Used in Oncology." Materials 14, no. 20 (2021): 5948. http://dx.doi.org/10.3390/ma14205948.

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Recently, magnetic nanoparticles (MNPs) have more and more often been used in experimental studies on cancer treatments, which have become one of the biggest challenges in medical research. The main goal of this research is to treat and to cure advanced or metastatic cancer with minimal side effects through nanotechnology. Drug delivery approaches take into account the fact that MNPs can be bonded to chemotherapeutical drugs, nucleic acids, synthetized antibodies or radionuclide substances. MNPs can be guided, and different treatment therapies can be applied, under the influence of an external
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11

Dowling, Reyne, and Mikhail Kostylev. "Controlled Capture of Magnetic Nanoparticles from Microfluidic Flows by Ferromagnetic Antidot and Dot Nanostructures." Nanomaterials 15, no. 2 (2025): 132. https://doi.org/10.3390/nano15020132.

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The capture of magnetic nanoparticles (MNPs) is essential in the separation and detection of MNPs for applications such as magnetic biosensing. The sensitivity of magnetic biosensors inherently depends upon the distribution of captured MNPs within the sensing area. We previously demonstrated that the distribution of MNPs captured from evaporating droplets by ferromagnetic antidot nanostructures can be controlled via an external magnetic field. In this paper, we demonstrate the capture of magnetic nanoparticles from a microfluidic flow by four variants of antidot array nanostructures etched int
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12

Etli Omur, Elif Elçin, Ayşegül Karadayı, and R. Seda Tığlı Aydın. "Matter and thermal characterisation of the magnetic nanoparticle-chitosan complex: the microwave hyperthermia application on tumour phantom." Advances in Natural Sciences: Nanoscience and Nanotechnology 16, no. 2 (2025): 025017. https://doi.org/10.1088/2043-6262/adc54f.

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Abstract The application of hyperthermia by induction of magnetic nanoparticles (MNPs) presents alternative approaches for diagnosis and treatment in the clinic. Magnetic nanoparticle hyperthermia (MNPH) can selectively heat the targeted malignant cells while preserving healthy tissue. However, being able to detect the characterizations of MNPs is important to be able to identify the matter. The aim of this is the investigation of matter characterization of magnetite (Fe3O4) nanoparticles (C-MNP) coated with chitosan and the MW hyperthermia (low-intensity and electrical field values) thermal e
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13

Yakar, Arzu, Gülistan Tansık, Tuğba Keskin, and Ufuk Gündüz. "Tailoring the magnetic behavior of polymeric particles for bioapplications." Journal of Polymer Engineering 33, no. 3 (2013): 265–74. http://dx.doi.org/10.1515/polyeng-2012-0034.

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Abstract In this study, magnetic polymeric nanoparticles were prepared use in for targeted drug delivery. First, iron oxide (Fe3O4) magnetic nanoparticles (MNPs) were synthesized by coprecipitation with ferrous and ferric chloride salts. Then, to render the MNPs hydrophobic, the surfaces were covered with oleic acid. Finally, the hydrophobic MNPs (H-MNPs) were encapsulated with polymer. The emulsion evaporation technique was used for the preparation of polymer-coated H-MNP. Poly(dl-lactide-co-glycolide) (PLGA) and chitosan-modified PLGA were used as polymers. The polymeric nanoparticles were c
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Sheetal, Shankar Malvankar. "Properties and Applications of Magnetic Nanoparticles." International Journal of Advance and Applied Research S6, no. 18 (2025): 569–74. https://doi.org/10.5281/zenodo.15260498.

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<em>Magnetic nanoparticles (MNPs) are a class of materials with magnetic behavior and nanoscale size are their unique properties. A wide range of industries, including biomedical, environmental, and industrial technologies, have used MNPs due to their small size, high surface-to-volume ratio, and tunable magnetic properties. The primary properties of MNPs are their high magnetization, superparamagnetism, and susceptibility to external magnetic fields, each of which can be modified and controlled for specific purposes. Applications for MNPs can be found in sensing technologies, data storage, an
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15

Aştefanoaei, I., and A. Stancu. "Magnetic Hyperthermia with biocompatible coated nanoparticles: A temperature analysis." IOP Conference Series: Materials Science and Engineering 1254, no. 1 (2022): 012023. http://dx.doi.org/10.1088/1757-899x/1254/1/012023.

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Abstract The magnetic nanoparticles (MNPs) having the special (magnetic and thermal) properties are promising for Magnetic Hyperthermia. To increase their biocompatibility, these MNPs are covered by different organic shells as: chitosan, oleic acid or silica. When an external time - dependent magnetic field is applied, the temperature developed within a malignant cell is strongly influenced by the type of the material which covers the magnetic nanoparticle. This paper studies the temperature field induced by the MNPs covered by an organic shell within a concentric tissues configuration (malign
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16

Huu, Cao Xuan, Nguyen Bao Linh, Nguyen Thi Hoang Yen, and Dang Duc Long. "Immobilizing Alcalase® Enzyme onto Magnetic Nanoparticles." Communications in Physics 24, no. 3S1 (2014): 121–26. http://dx.doi.org/10.15625/0868-3166/24/3s1/5464.

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In recent years, magnetic nanoparticles (MNPs) have been applied to numerous biological systems. The nanoparticles are particularly useful in separating biological molecules due to its low price, scalable ability and very little interference. Here, MNPs, which can efficiently separate biocatalysts from reaction media by external magnet, was used to immobilize an alkaline protease (Alcalase®). Covalent attachment of the enzyme to MNPs began with the functionalization of the MNPs' surface with amines (APTES). Then, glutaraldehyde was introduced to link the MNP surface amines with enzyme surface
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17

Erdem, M., S. Yalcin, and U. Gunduz. "Folic acid-conjugated polyethylene glycol-coated magnetic nanoparticles for doxorubicin delivery in cancer chemotherapy: Preparation, characterization and cytotoxicity on HeLa cell line." Human & Experimental Toxicology 36, no. 8 (2016): 833–45. http://dx.doi.org/10.1177/0960327116672910.

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Conventional chemotherapy is the most valid method to cope with cancer; however, it has serious drawbacks such as decrease in production of blood cells or inflammation of the lining of the digestive tract. These side effects occur since generally the drugs used in chemotherapy are distributed evenly within the body of the patient and cannot distinguish the cancer cells from the healthy ones. In this study, folic acid (FA)-conjugated, polyethylene-coated magnetic nanoparticles (FA-MNPs), and doxorubicin (Dox)-loaded formulation (Dox-FA-MNPs) were prepared. The cytotoxicity of these nanoparticle
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18

Liu, Xin, Nan Wang, Xiyu Liu, Rongrong Deng, Ran Kang, and Lin Xie. "Vascular Repair by Grafting Based on Magnetic Nanoparticles." Pharmaceutics 14, no. 7 (2022): 1433. http://dx.doi.org/10.3390/pharmaceutics14071433.

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Magnetic nanoparticles (MNPs) have attracted much attention in the past few decades because of their unique magnetic responsiveness. Especially in the diagnosis and treatment of diseases, they are mostly involved in non-invasive ways and have achieved good results. The magnetic responsiveness of MNPs is strictly controlled by the size, crystallinity, uniformity, and surface properties of the synthesized particles. In this review, we summarized the classification of MNPs and their application in vascular repair. MNPs mainly use their unique magnetic properties to participate in vascular repair,
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19

Taira, Shu, Daisaku Kaneko, Kazuki Onuma, et al. "Synthesis and Characterization of Functionalized Magnetic Nanoparticles for the Detection of Pesticide." International Journal of Inorganic Chemistry 2012 (June 5, 2012): 1–7. http://dx.doi.org/10.1155/2012/439751.

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We synthesized magnetic nanoparticles (MNPs) by mixing aqueous solutions of 3d transition metal chlorides (MCl2·nH2O) and a sodium metasilicate nonahydrate (Na2SiO3·9H2O) in order to produce monodispersed MNPs in a single step. The particle size can be controlled by adjusting the annealing temperature. We characterized the MNPs by X-ray diffraction (XRD), superconducting quantum interference device (SQUID), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR), and zeta-potential measurement. Paramagnetic and superparamagnetic behaviors were found for the obtained samples
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20

Zhou, Shengli, Kaname Tsutsumiuchi, Ritsuko Imai, et al. "In Vitro Study of Tumor-Homing Peptide-Modified Magnetic Nanoparticles for Magnetic Hyperthermia." Molecules 29, no. 11 (2024): 2632. http://dx.doi.org/10.3390/molecules29112632.

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Cancer cells have higher heat sensitivity compared to normal cells; therefore, hyperthermia is a promising approach for cancer therapy because of its ability to selectively kill cancer cells by heating them. However, the specific and rapid heating of tumor tissues remains challenging. This study investigated the potential of magnetic nanoparticles (MNPs) modified with tumor-homing peptides (THPs), specifically PL1 and PL3, for tumor-specific magnetic hyperthermia therapy. The synthesis of THP-modified MNPs involved the attachment of PL1 and PL3 peptides to the surface of the MNPs, which facili
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Liu, Yangyang, Zhiyu Qian, Jianhua Yin, and Xiao Wang. "Tumor therapy by fast moving magnetic nanoparticle under low-frequency alternating magnetic field." Journal of Innovative Optical Health Sciences 08, no. 02 (2015): 1550008. http://dx.doi.org/10.1142/s179354581550008x.

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Magnetic nanoparticle plays an important role in biomedical engineering, especially in tumor therapy. In this paper, a new technique has been developed by using the rapid moving magnetic nanoparticle under a low-frequency alternating magnetic field (LFAMF) to kill tumor cells. The LFAMF system which was used to drive magnetic nanoparticles (MNPs) was setup with the magnetic field frequency and power range at ∼ 10–100 Hz and ∼ 10–200 mT, respectively. During the experiment, the LFAMF was adjusted at different frequencies and power levels. The experimental results show that the liver tumor cells
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Baki, Abdulkader, Frank Wiekhorst, and Regina Bleul. "Advances in Magnetic Nanoparticles Engineering for Biomedical Applications—A Review." Bioengineering 8, no. 10 (2021): 134. http://dx.doi.org/10.3390/bioengineering8100134.

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Magnetic iron oxide nanoparticles (MNPs) have been developed and applied for a broad range of biomedical applications, such as diagnostic imaging, magnetic fluid hyperthermia, targeted drug delivery, gene therapy and tissue repair. As one key element, reproducible synthesis routes of MNPs are capable of controlling and adjusting structure, size, shape and magnetic properties are mandatory. In this review, we discuss advanced methods for engineering and utilizing MNPs, such as continuous synthesis approaches using microtechnologies and the biosynthesis of magnetosomes, biotechnological synthesi
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23

Ryzhov, Vyacheslav, Yaroslav Marchenko, Vladimir Deriglazov, et al. "Nonlinear Magnetic Response Measurements in Study of Magnetic Nanoparticles Uptake by Mesenchymal Stem Cells." Nanomaterials 15, no. 9 (2025): 675. https://doi.org/10.3390/nano15090675.

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Stem cells therapies offer a promising approach in translational oncology, as well as in regenerative medicine due to the tropism of these cells to the damage site. To track the distribution of stem cells, the latter could be labeled by MRI-sensitive superparamagnetic (SPM) iron oxide nanoparticles. In the current study, magnetic properties of the magnetic nanoparticles (MNPs) incorporated into the bone marrow-derived fetal mesenchymal stem cells (FetMSCs) were evaluated employing nonlinear magnetic response measurements. Synthesized dextran-coated iron oxide nanoparticles were additionally ch
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Babu, Abhinav, Aniket Bhardwaj, and Saurabh Verma. "Magnetic nanoparticles (MNPs): Design, characterization, release mechanism and remote-controlled application for targeted therapeutics." International Journal of Research in Pharmaceutical Sciences 15, no. 3 (2024): 117–35. http://dx.doi.org/10.26452/ijrps.v15i3.4704.

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MNPs as novel drug delivery system (NDDS) approach possess several magnetic properties for targeted and controlled delivery in various biomedical application. Unlike normal nanoparticles, MNPs enable to respond to external magnetic fields, allowing for manipulation, guidance, and functionalisation within the body. This review encompasses a wide range of scientific and technological goals aimed in understanding their properties, synthesis methods, characterization techniques, surface functionalisation strategies and application. Drug delivery based on magnetic properties has advanced dramatical
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Budnyk, A. P., T. A. Lastovina, A. L. Bugaev, et al. "Gd3+-Doped Magnetic Nanoparticles for Biomedical Applications." Journal of Spectroscopy 2018 (August 2, 2018): 1–9. http://dx.doi.org/10.1155/2018/1412563.

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Magnetic nanoparticles (MNPs) made of iron oxides with cubic symmetry (Fe3O4, γ-Fe2O3) are demanded objects for multipurpose in biomedical applications as contrast agents for magnetic resonance imaging, magnetically driven carriers for drug delivery, and heaters in hyperthermia cancer treatment. An optimum balance between the right particle size and good magnetic response can be reached by a selection of a synthesis method and by doping with rare earth elements. Here, we present a microwave-assisted polyol synthesis of iron oxide MNPs with actual gadolinium (III) doping from 0.5 to 5.1 mol.%.
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SHAMILI, K., E. M. RAJESH, R. RAJENDRAN, S. R. MADHAN SHANKAR, M. ELANGO, and N. ABITHA DEVI. "COLLOIDAL STABILITY AND MONODISPERSIBLE MAGNETIC IRON OXIDE NANOPARTICLES IN BIOTECHNOLOGY APPLICATION." International Journal of Nanoscience 12, no. 06 (2013): 1330002. http://dx.doi.org/10.1142/s0219581x13300010.

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Magnetic iron oxide nanoparticles are promising material for various biological applications. In the recent decades, magnetic iron oxide nanoparticles (MNPs) have great attention in biomedical applications such as drug delivery, magnetic resonance imaging (MRI) and magnetic fluid hyperthermia (MFH). This review focuses on the colloidal stability and monodispersity properties of MNPs, which pay more attention toward biomedical applications. The simplest and the most promising method for the synthesis of MNPs is co-precipitation. The biocompatible MNPs are more interested in MRI application. Thi
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Leal-Marin, Sara, Glynn Gallaway, Kai Höltje, Alex Lopera-Sepulveda, Birgit Glasmacher, and Oleksandr Gryshkov. "Scaffolds with Magnetic Nanoparticles for Tissue Stimulation." Current Directions in Biomedical Engineering 7, no. 2 (2021): 460–63. http://dx.doi.org/10.1515/cdbme-2021-2117.

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Abstract Magnetic nanoparticles (MNPs) have been used in several medical applications, including targeted hyperthermia, resonance tomography, diagnostic sensors, and localized drug delivery. Further applications of magnetic field manipulation through MNPs in tissue engineering have been described. The current study aims to develop tissue-engineered polymeric scaffolds with incorporated MNPs for applications that require stimulation of the tissues such as nerves, muscles, or heart. Electrospun scaffolds were obtained using 14%w/v polycaprolactone (PCL) in 2,2,2-Trifluoroethanol (TFE) at concent
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28

Huber, Christian Marinus, Christian Heim, Jiaqi Li, et al. "Magnetomotive Displacement of Magnetic Nanoparticles in Different Tissue Phantoms." Current Directions in Biomedical Engineering 10, no. 4 (2024): 324–27. https://doi.org/10.1515/cdbme-2024-2079.

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Abstract Magnetic nanoparticles (MNPs) can be used in various biomedical applications, such as magnetic drug targeting (MDT) or magnetic hyperthermia for cancer treatment. MNPs are injected into the body and accumulated with an external magnetic field at the tumor site. For therapy monitoring, the MNPs distribution has to be accurately mapped in real time. Magnetomotive ultrasound (MMUS) is a suitable technique for this purpose. It was already demonstrated that MMUS can map the accumulation process of MNPs during MDT. Moreover, inverse MMUS is an advanced technique to quantify MNP distribution
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Chmelyuk, Nelly S., Aleksey A. Nikitin, Veronika V. Vadekhina, Vladimir A. Mitkevich, and Maxim A. Abakumov. "Targeted Magnetic Nanoparticles for Beta-Amyloid Detection." Pharmaceutics 16, no. 11 (2024): 1395. http://dx.doi.org/10.3390/pharmaceutics16111395.

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Background/Objectivities: The presence of beta-amyloid plaques is a part of the pathogenesis of Alzheimer’s disease, but there is currently no universally accepted method for magnetic resonance (MR) imaging of the disease. However, it is known that magnetic nanoparticles (MNPs) can improve the T2 contrast in MR images of various targets. Methods: We used cubic MNPs, which were produced by thermal decomposition and then it was covalently bonded to a modified fluorescently labeled tetrapeptide, HAEE-Cy5, for visualizing beta-amyloid plaques. The interaction of MNPs-HAEE-Cy5 and beta-amyloid was
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Dowaidar, Moataz, Hani Nasser Abdelhamid, Mattias Hällbrink, Ülo Langel, and Xiaodong Zou. "Chitosan enhances gene delivery of oligonucleotide complexes with magnetic nanoparticles–cell-penetrating peptide." Journal of Biomaterials Applications 33, no. 3 (2018): 392–401. http://dx.doi.org/10.1177/0885328218796623.

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Gene-based therapies, including the delivery of oligonucleotides, offer promising methods for the treatment of cancer cells. However, they have various limitations including low efficiency. Herein, cell-penetrating peptides (CPPs)-conjugated chitosan-modified iron oxide magnetic nanoparticles (CPPs-CTS@MNPs) with high biocompatibility as well as high efficiency were tested for the delivery of oligonucleotides such as plasmid pGL3, splice correction oligonucleotides, and small-interfering RNA. A biocompatible nanocomposite, in which CTS@MNPs was incorporated in non-covalent complex with CPPs-ol
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Obaidat, Ihab M., Venkatesha Narayanaswamy, Sulaiman Alaabed, Sangaraju Sambasivam, and Chandu V. V. Muralee Gopi. "Principles of Magnetic Hyperthermia: A Focus on Using Multifunctional Hybrid Magnetic Nanoparticles." Magnetochemistry 5, no. 4 (2019): 67. http://dx.doi.org/10.3390/magnetochemistry5040067.

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Hyperthermia is a noninvasive method that uses heat for cancer therapy where high temperatures have a damaging effect on tumor cells. However, large amounts of heat need to be delivered, which could have negative effects on healthy tissues. Thus, to minimize the negative side effects on healthy cells, a large amount of heat must be delivered only to the tumor cells. Magnetic hyperthermia (MH) uses magnetic nanoparticles particles (MNPs) that are exposed to alternating magnetic field (AMF) to generate heat in local regions (tissues or cells). This cancer therapy method has several advantages, s
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Paun, Irina Alexandra, Bogdan Stefanita Calin, Cosmin Catalin Mustaciosu, et al. "3D Superparamagnetic Scaffolds for Bone Mineralization under Static Magnetic Field Stimulation." Materials 12, no. 17 (2019): 2834. http://dx.doi.org/10.3390/ma12172834.

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We reported on three-dimensional (3D) superparamagnetic scaffolds that enhanced the mineralization of magnetic nanoparticle-free osteoblast cells. The scaffolds were fabricated with submicronic resolution by laser direct writing via two photons polymerization of Ormocore/magnetic nanoparticles (MNPs) composites and possessed complex and reproducible architectures. MNPs with a diameter of 4.9 ± 1.5 nm and saturation magnetization of 30 emu/g were added to Ormocore, in concentrations of 0, 2 and 4 mg/mL. The homogenous distribution and the concentration of the MNPs from the unpolymerized Ormocor
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33

Hepel, Maria. "Magnetic Nanoparticles for Nanomedicine." Magnetochemistry 6, no. 1 (2020): 3. http://dx.doi.org/10.3390/magnetochemistry6010003.

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The field of nanomedicine has recently emerged as a product of the expansion of a range of nanotechnologies into biomedical science, pharmacology and clinical practice. Due to the unique properties of nanoparticles and the related nanostructures, their applications to medical diagnostics, imaging, controlled drug and gene delivery, monitoring of therapeutic outcomes, and aiding in medical interventions, provide a new perspective for challenging problems in such demanding issues as those involved in the treatment of cancer or debilitating neurological diseases. In this review, we evaluate the r
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Mostafa Yusefi, Kamyar Shameli, and Siti Nur Amalina Mohamad Sukri. "Magnetic Nanoparticles In Hyperthermia Therapy: A Mini-Review." Journal of Research in Nanoscience and Nanotechnology 2, no. 1 (2021): 51–60. http://dx.doi.org/10.37934/jrnn.2.1.5160.

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The activation of MNPs for hyperthermia therapy via an external alternating magnetic field is an interesting method in targeted cancer therapy. This mini-review explains new developments and implications of magnetic nanofluids mediated magnetic hyperthermia for their potential use in future clinical settings. The external alternating magnetic field generates heat in the tumor area to eliminate cancer cells. Depending on the tumor type and targeted area, several kinds of MNPs with different coating agents of various morphology and surface charge have been developed. The tunable physiochemical c
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Bilal, Muhammad, Shahid Mehmood, Tahir Rasheed, and Hafiz M. N. Iqbal. "Bio-Catalysis and Biomedical Perspectives of Magnetic Nanoparticles as Versatile Carriers." Magnetochemistry 5, no. 3 (2019): 42. http://dx.doi.org/10.3390/magnetochemistry5030042.

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In recent years, magnetic nanoparticles (MNPs) have gained increasing attention as versatile carriers because of their unique magnetic properties, biocatalytic functionalities, and capabilities to work at the cellular and molecular level of biological interactions. Moreover, owing to their exceptional functional properties, such as large surface area, large surface-to-volume ratio, and mobility and high mass transference, MNPs have been employed in several applications in different sectors such as supporting matrices for enzymes immobilization and controlled release of drugs in biomedicine. Un
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Feng, Jie, Rui Lin Zhang, Ya Nan Qu, Ping Geng, and Shou Liang Qi. "Trajectory Simulation of Magnetic Nanoparticles in the Blood Vessel for the Magnetic Targeted-Drug Delivery." Advanced Materials Research 753-755 (August 2013): 988–94. http://dx.doi.org/10.4028/www.scientific.net/amr.753-755.988.

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Magnetic nanoparticles (MNPs) have been considered as potential therapeutic agent carrier for the magnetic targeted-drug delivery in the fight against cancer. Trajectories of MNPs in the blood vessel determine the capture and retention ratio, and the final effectiveness of the treatment. In the present study, a theoretical model of MNPs trajectory is deduced at first. Then two kinds of magnets are proposed, and their magnetic field distributions are calculated through the finite element method software of ANSYS. Using the model and magnetic field inputs, the MNPs trajectories are determined, a
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Kim, Hye Su, Ji Sun Lee та Moon Il Kim. "Poly-γ-Glutamic Acid/Chitosan Hydrogel Nanoparticles Entrapping Glucose Oxidase and Magnetic Nanoparticles for Glucose Biosensing". Journal of Nanoscience and Nanotechnology 20, № 9 (2020): 5333–37. http://dx.doi.org/10.1166/jnn.2020.17660.

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We have developed hydrogel nanoparticles made of poly-γ-glutamic acid (PGA) and chitosan, which entraps both glucose oxidase (GOx) and magnetic nanoparticles (MNPs) within the hydrogel matrix. The preparation of poly-γ-glutamic acid/chitosan hydrogel nanoparticles (PGA/CS NPs) entrapping GOx and MNPs begins with the mixing of GOx and MNPs with PGA solution followed by their dropwise addition into chitosan solution to induce rapid ionic gelation. The glucose sensing relies on the generation of H2O2 through the entrapped GOx-mediated catalysis in the presence of glucose, which consequently activ
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Cao, Yixiang, Shiyin Zhang, Ming Ma, and Yu Zhang. "Fluorinated PEG-PEI Coated Magnetic Nanoparticles for siRNA Delivery and CXCR4 Knockdown." Nanomaterials 12, no. 10 (2022): 1692. http://dx.doi.org/10.3390/nano12101692.

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CXC chemokine receptor 4 (CXCR4) is a promising therapeutic target. Previous studies have shown that intracellular delivery of siRNA to knockdown CXCR4 expression in cancer cells is an effective therapeutic strategy. To prepare efficient magnetic nucleic acid carriers, it is now necessary to improve the endocytosis efficiency of PEGylated magnetic nanoparticles. In our work, Heptafluorobutyryl-polyethylene glycol-polyethyleneimine (FPP) was first prepared and then used to coat magnetic nanoparticles (MNPs) to obtain magnetic nanocarriers FPP@MNPs. The materials were characterized by 19 F-Nucle
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Das, Amrita, Prateep Sengupta, Shreya Chatterjee, et al. "Development and Evaluation of Magnetite Loaded Alginate Beads Based Nanocomposite for Enhanced Targeted Analgesic Drug Delivery." Magnetochemistry 11, no. 2 (2025): 14. https://doi.org/10.3390/magnetochemistry11020014.

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Iron oxide-based nanoparticles, such as magnetic nanoparticles (MNPs), have gained significant attention in the area of drug delivery due to their unique magnetic properties, allowing for precise targeting and controlled release of therapeutic agents. Several successful research studies were reported with combinations of magnetic nanoparticles and polysaccharides such as sodium alginate, chitosan, cellulose, etc. The presented research work is based on synthesising MNPs via the co-precipitation method and their successful encapsulation within alginate beads, serving as a promising drug deliver
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Irfai, Rizal A., Roto Roto, and Nurul Hidayat Aplrilita. "Preparation of Fe3O4@SiO2 Nanoparticles for Adsorption of Waste Containing Cu2+ Ions." Key Engineering Materials 840 (April 2020): 43–47. http://dx.doi.org/10.4028/www.scientific.net/kem.840.43.

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The magnetic adsorbent of Fe3O4@SiO2 nanoparticle is modified with an amine group for recovery electroplating industrial waste, which contains Cu2+ ion. The magnetic nanoparticles (MNPs) were prepared by the coprecipitation method under sonication and were coated with SiO2 by acid hydrolysis of sodium citrate under N2 purging. The nanoparticles were prepared by a coating of silica onto the magnetite nanoparticles via controlled hydrolysis of tetraethyl orthosilicate (TEOS). TEM images suggest that the products have a spherical shape with a particle size of about 20 nm in diameter, and the sili
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41

Ha, Yeonjeong. "Exploiting the Potential of Magnetic Nanoparticles for Rapid Diagnosis Tests (RDTs): Nanoparticle-Antibody Conjugates and Color Development Strategies." Diagnostics 13, no. 19 (2023): 3033. http://dx.doi.org/10.3390/diagnostics13193033.

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Magnetic nanoparticles (MNPs) have emerged as a promising material in disease diagnostics due to their potential to enhance detection sensitivity, facilitate concentration and purification of target substances in diverse samples, and enable favorable color-based detection. In this study, antibody-conjugated MNPs were successfully synthesized and validated through two appropriate methods: the measurement of MNPs’ size and the use of phosphatase methods. Additionally, three methods were suggested and implemented for developing color in MNPs-based immunoassay, including the formation of MNP aggre
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42

Farinha, Pedro, João M. P. Coelho, Catarina Pinto Reis, and Maria Manuela Gaspar. "A Comprehensive Updated Review on Magnetic Nanoparticles in Diagnostics." Nanomaterials 11, no. 12 (2021): 3432. http://dx.doi.org/10.3390/nano11123432.

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Magnetic nanoparticles (MNPs) have been studied for diagnostic purposes for decades. Their high surface-to-volume ratio, dispersibility, ability to interact with various molecules and superparamagnetic properties are at the core of what makes MNPs so promising. They have been applied in a multitude of areas in medicine, particularly Magnetic Resonance Imaging (MRI). Iron oxide nanoparticles (IONPs) are the most well-accepted based on their excellent superparamagnetic properties and low toxicity. Nevertheless, IONPs are facing many challenges that make their entry into the market difficult. To
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Terziyan, Tatyana V., Alexander P. Safronov, Igor V. Beketov, Anatoly I. Medvedev, Sergio Fernandez Armas, and Galina V. Kurlyandskaya. "Adhesive and Magnetic Properties of Polyvinyl Butyral Composites with Embedded Metallic Nanoparticles." Sensors 21, no. 24 (2021): 8311. http://dx.doi.org/10.3390/s21248311.

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Magnetic metallic nanoparticles (MNPs) of Ni, Ni82Fe18, Ni50Fe50, Ni64Fe36, and Fe were prepared by the technique of the electrical explosion of metal wire. The average size of the MNPs of all types was in the interval of 50 to 100 nm. Magnetic polymeric composites based on polyvinyl butyral with embedded metal MNPs were synthesized and their structural, adhesive, and magnetic properties were comparatively analyzed. The interaction of polyvinyl butyral (supplied as commercial GE cryogenic varnish) with metal MNPs was studied by microcalorimetry. The enthalpy of adhesion was also evaluated. The
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Yang, Hee-Man, Hye Min Choi, Sung-Chan Jang, et al. "Succinate Functionalization of Hyperbranched Polyglycerol-Coated Magnetic Nanoparticles as a Draw Solute During Forward Osmosis." Journal of Nanoscience and Nanotechnology 15, no. 10 (2015): 8279–84. http://dx.doi.org/10.1166/jnn.2015.11244.

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Hyperbranched polyglycerol-coated magnetic nanoparticles (SHPG-MNPs) were functionalized with succinate groups to form a draw solute for use in a forward osmosis (FO). After the one-step synthesis of hyperbranched polyglycerol-coated magnetic nanoparticles (HPG-MNPs), the polyglycerol groups on the surfaces of the HPG-MNPs were functionalized with succinic anhydride moieties. The resulting SHPG-MNPs showed no change of size and magnetic property compared with HPGMNPs and displayed excellent dispersibility in water up to the concentration of 400 g/L. SHPG-MNPs solution showed higher osmotic pre
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Luiz, Marcela Tavares, Jessyca Aparecida Paes Dutra, Juliana Santos Rosa Viegas, Jennifer Thayanne Cavalcante de Araújo, Alberto Gomes Tavares Junior, and Marlus Chorilli. "Hybrid Magnetic Lipid-Based Nanoparticles for Cancer Therapy." Pharmaceutics 15, no. 3 (2023): 751. http://dx.doi.org/10.3390/pharmaceutics15030751.

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Cancer is one of the major public health problems worldwide. Despite the advances in cancer therapy, it remains a challenge due to the low specificity of treatment and the development of multidrug resistance mechanisms. To overcome these drawbacks, several drug delivery nanosystems have been investigated, among them, magnetic nanoparticles (MNP), especially superparamagnetic iron oxide nanoparticles (SPION), which have been applied for treating cancer. MNPs have the ability to be guided to the tumor microenvironment through an external applied magnetic field. Furthermore, in the presence of an
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Oltolina, Francesca, Donato Colangelo, Ivana Miletto, et al. "Tumor Targeting by Monoclonal Antibody Functionalized Magnetic Nanoparticles." Nanomaterials 9, no. 11 (2019): 1575. http://dx.doi.org/10.3390/nano9111575.

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Tumor-targeted drug-loaded nanocarriers represent innovative and attractive tools for cancer therapy. Several magnetic nanoparticles (MNPs) were analyzed as potential tumor-targeted drug-loaded nanocarriers after functionalization with anti-Met oncogene (anti-Met/HGFR) monoclonal antibody (mAb) and doxorubicin (DOXO). Their cytocompatibility, stability, immunocompetence (immunoprecipitation), and their interactions with cancer cells in vitro (Perl’s staining, confocal microscopy, cytotoxic assays: MTT, real time toxicity) and with tumors in vivo (Perl’s staining) were evaluated. The simplest s
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Li, Ying, Ning Tang, Fuyuhiko Inagaki, Chisato Mukai, and Kazuichi Hayakawa. "Characterization and Functionality of Immidazolium Ionic Liquids Modified Magnetic Nanoparticles." Journal of Chemistry 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/861021.

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1,3-Dialkylimidazolium-based ionic liquids were chemically synthesized and bonded on the surface of magnetic nanoparticles (MNPs) with easy one-step reaction. The obtained six kinds of ionic liquid modified MNPs were characterized with transmission electron microscopy, thermogravimetric analysis, magnetization, and FTIR, which owned the high adsorption capacity due to the nanometer size and high-density modification with ionic liquids. Functionality of MNPs with ionic liquids greatly influenced the solubility of the MNPs with organic solvents depending on the alkyl chain length and the anions
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Godjevargova, Tzonka, Yavor Ivanov, Milka Atanasova, Zlatina Becheva, and Anatoly Zherdev. "Magnetic nanoparticles based fluorescence immunoassay for food contaminants." Food Science and Applied Biotechnology 2, no. 1 (2019): 38. http://dx.doi.org/10.30721/fsab2019.v2.i1.52.

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Nanotechnology provides exciting new possibilities for advanced development of new analytical tools and instruments for bioanalytical applications. Magnetic nanoparticles (MNPs) have attracted much research interest in the past decade because they have good biocompatibility and can be readily separated from reaction mixtures with the aid of an external magnetic field. Heterogenic fluorescent immunoassays for determination of different analytes (antibiotics, pesticides, progesterone, aflatoxins, enterotoxins) using MNPs were developed. MNPs were prepared by thermal co-precipitation of Fe2+ and
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49

Yee, Li Ying, Qi Hwa Ng, Siti Kartini Enche Ab Rahim, et al. "A Novel Tri-Functionality pH-Magnetic-Photocatalytic Hybrid Organic-Inorganic Polyoxometalates Augmented Microspheres for Polluted Water Treatment." Membranes 13, no. 2 (2023): 174. http://dx.doi.org/10.3390/membranes13020174.

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The severe water pollution from effluent dyes threatens human health. This study created pH-magnetic-photocatalytic polymer microspheres to conveniently separate the photocatalyst nanoparticles from the treated water by applying an external magnetic field. While fabricating magnetic nanoparticles’ (MNPs) microspheres, incorporating 0.5 wt.% iron oxide (Fe3O4) showed the best magnetophoretic separation ability, as all the MNPs microspheres were attracted toward the external magnet. Subsequently, hybrid organic–inorganic polyoxometalates (HPOM), a self-synthesized photocatalyst, were linked with
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50

Chen, Fang, Minjuan Bian, Michael Nahmou, David Myung, and Jeffrey L. Goldberg. "Fusogenic liposome-enhanced cytosolic delivery of magnetic nanoparticles." RSC Advances 11, no. 57 (2021): 35796–805. http://dx.doi.org/10.1039/d1ra03094a.

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