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Journal articles on the topic 'Magnetic resonance imaging, voxel based morphometry, tract based spatial statistics'

Author: Grafiati

Published: 11 March 2023

Last updated: 31 July 2025

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1

Pichiecchio, A., E. Tavazzi, G. Poloni, et al. "Advanced magnetic resonance imaging of neuromyelitis optica: a multiparametric approach." Multiple Sclerosis Journal 18, no. 6 (2011): 817–24. http://dx.doi.org/10.1177/1352458511431072.

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Background: Several authors have used advanced magnetic resonance imaging (MRI) techniques to investigate whether patients with neuromyelitis optica (NMO) have occult damage in normal-appearing brain tissue, similarly to multiple sclerosis (MS). To date, the literature contains no data derived from the combined use of several advanced MRI techniques in the same NMO subjects. Objective: We set out to determine whether occult damage could be detected in the normal-appearing brain tissue of a small group of patients with NMO using a multiparametric MRI approach. Methods: Eight female patients aff

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Ota, Miho, Yasuhiro Nakata, Kimiteru Ito, et al. "Differential Diagnosis Tool for Parkinsonian Syndrome Using Multiple Structural Brain Measures." Computational and Mathematical Methods in Medicine 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/571289.

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Clinical differentiation of parkinsonian syndromes such as the Parkinson variant of multiple system atrophy (MSA-P) and cerebellar subtype (MSA-C) from Parkinson's disease is difficult in the early stage of the disease. To identify the correlative pattern of brain changes for differentiating parkinsonian syndromes, we applied discriminant analysis techniques by magnetic resonance imaging (MRI). T1-weighted volume data and diffusion tensor images were obtained by MRI in eighteen patients with MSA-C, 12 patients with MSA-P, 21 patients with Parkinson’s disease, and 21 healthy controls. They were

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Hartmann, Tue, Sanne Vandborg, Raben Rosenberg, Leif Sørensen, and Poul Videbech. "Increased fractional anisotropy in cerebellum in obsessive–compulsive disorder." Acta Neuropsychiatrica 28, no. 3 (2015): 141–48. http://dx.doi.org/10.1017/neu.2015.57.

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BackgroundPrevious morphology and diffusion-imaging studies have suggested that structural changes in white matter is an important part of the pathophysiology of obsessive–compulsive disorder (OCD). However, different methodological approaches and the heterogeneity of patient samples question the validity of the findings.Materials and methodsIn total, 30 patients were matched for age and sex with 30 healthy controls. All participants underwent T1-weighted magnetic resonance imaging, diffusion tensor imaging and T2 fluid-attenuated inversion recovery. Voxel-based morphometry and tract-based spa

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Beckmann, Yesim, Sevgin Gökçe, Nabi Zorlu, H. Sabiha Türe, and Fazıl Gelal. "Longitudinal assessment of gray matter volumes and white matter integrity in patients with medication-overuse headache." Neuroradiology Journal 31, no. 2 (2018): 150–56. http://dx.doi.org/10.1177/1971400918756374.

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Background Medication-overuse headache is a common clinical entity, but neuroimaging studies investigating volumetric and microstructural alterations of the brain in medication-overuse headache are rare. Therefore, in the current longitidunal study we evaluated gray matter volume and white matter integrity in patients with medication-overuse headache before and after drug withdrawal. Methods A prospective study evaluated 27 patients with medication-overuse headache and 27 age-, sex-, and education-matched healthy adults. High-resolution T1-weighted magnetic resonance imaging and diffusion tens

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Zou, Liwei, Xiaoyan Wu, Shuman Tao, et al. "Anterior cingulate gyrus acts as a moderator of the relationship between problematic mobile phone use and depressive symptoms in college students." Social Cognitive and Affective Neuroscience 16, no. 5 (2021): 484–91. http://dx.doi.org/10.1093/scan/nsab016.

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Abstract This study aimed to investigate the brain grey matter volume (GMV) related to problematic mobile phone use (PMPU), and whether these regions of GMV play a potential moderating role in the relationship between PMPU and depressive symptoms. We recruited 266 students who underwent magnetic resonance imaging (MRI) scanning. PMPU and depressive symptoms were assessed by a self-rating questionnaire for adolescent PMPU and patient health questionnaire-9, respectively. A multiple regression model was performed to detect GMV and white matter (WM) integrity associated with PMPU by voxel-based m

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Lacey, Colleen, Theone Paterson та Jodie R. Gawryluk. "Impact of APOE-ε alleles on brain structure and cognitive function in healthy older adults: A VBM and DTI replication study". PLOS ONE 19, № 4 (2024): e0292576. http://dx.doi.org/10.1371/journal.pone.0292576.

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Background The Apolipoprotein E (APOE) gene has been established in the Alzheimer’s disease (AD) literature to impact brain structure and function and may also show congruent effects in healthy older adults, although findings in this population are much less consistent. The current study aimed to replicate and expand the multimodal approach employed by Honea et al. Structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), and neuropsychological measures were used to investigate the impact of APOE-ε status on grey matter structure, white matter integrity, and cognitive functi

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Lacey, Colleen, Jodie Gawryluk та Theone Paterson. "4 Impact of APOE-ε Alleles on Brain Structure and Function in Healthy Older Adults: A VBM and DTI Replication Study". Journal of the International Neuropsychological Society 29, s1 (2023): 882–83. http://dx.doi.org/10.1017/s135561772301086x.

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Objective:The Apolipoprotein E (APOE) gene has been established in the Alzheimer’s disease (AD) literature to impact brain structure and function and may also show congruent effects in healthy older adults, although findings in this population are much less consistent. Magnetic Resonance Imaging (MRI), Diffusion Tensor Imaging (DTI), and neuropsychological measures present as useful, non-invasive tools to investigate the impact of APOE-e allele status on grey matter structure, white matter integrity, and cognitive functioning, respectively. Nonetheless, studies to date have revealed mix findin

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Sexton, Claire E., Marisa Le Masurier, Charlotte L. Allan, et al. "Magnetic resonance imaging in late-life depression: vascular and glucocorticoid cascade hypotheses." British Journal of Psychiatry 201, no. 1 (2012): 46–51. http://dx.doi.org/10.1192/bjp.bp.111.105361.

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BackgroundLate-life depression is a common and heterogeneous illness, associated with structural abnormalities in both grey and white matter.AimsTo examine the relationship between age at onset and magnetic resonance imaging (MRI) measures of grey and white matter to establish whether they support particular hypotheses regarding the anatomy and aetiology of network disruption in late-life depression.MethodWe studied 36 participants with late-life depression. Grey matter was examined using T1-weighted MRI and analysed using voxel-based morphometry. The hippocampus was automatically segmented an

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Goto, Masami, Osamu Abe, Junichi Hata, et al. "Adverse effects of metallic artifacts on voxel-wise analysis and tract-based spatial statistics in diffusion tensor imaging." Acta Radiologica 58, no. 2 (2016): 211–17. http://dx.doi.org/10.1177/0284185116641348.

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Background Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique that reflects the Brownian motion of water molecules constrained within brain tissue. Fractional anisotropy (FA) is one of the most commonly measured DTI parameters, and can be applied to quantitative analysis of white matter as tract-based spatial statistics (TBSS) and voxel-wise analysis. Purpose To show an association between metallic implants and the results of statistical analysis (voxel-wise group comparison and TBSS) for fractional anisotropy (FA) mapping, in DTI of healthy adults. Material and Met

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Gobbi, C., MA Rocca, E. Pagani, et al. "Forceps minor damage and co-occurrence of depression and fatigue in multiple sclerosis." Multiple Sclerosis Journal 20, no. 12 (2014): 1633–40. http://dx.doi.org/10.1177/1352458514530022.

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Objective: Using diffusion tensor magnetic resonance imaging (DT MRI), we analyzed the architectural integrity of the brain white matter (WM) from a large cohort of MS patients to identify the structural substrates of the concomitant presence of depression and fatigue. Methods: Brain dual-echo, 3D T1-weighted and DT MRI scans were acquired from 147 MS patients and 90 gender- and age-matched healthy controls (HCs). Patients were stratified by the presence of depression (92 depressed (D), 55 not depressed (nD)) and fatigue (81 fatigued (F), 66 not fatigued (nF)). Sixty-five patients had co-occur

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Li, Dan, Shenghong Li, and Xianjun Zeng. "Analysis of alterations in white matter integrity of adult patients with comitant exotropia." Journal of International Medical Research 46, no. 5 (2018): 1963–72. http://dx.doi.org/10.1177/0300060518763704.

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Objective This study was performed to investigate structural abnormalities of the white matter in patients with comitant exotropia using the tract-based spatial statistics (TBSS) method. Methods Diffusion tensor imaging data from magnetic resonance images of the brain were collected from 20 patients with comitant exotropia and 20 age- and sex-matched healthy controls. The FMRIB Software Library was used to compute the diffusion measures, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD). These measures were obtained using voxel-wis

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Gryglewski, Gregor, René Seiger, Pia Baldinger-Melich, et al. "Changes in White Matter Microstructure After Electroconvulsive Therapy for Treatment-Resistant Depression." International Journal of Neuropsychopharmacology 23, no. 1 (2019): 20–25. http://dx.doi.org/10.1093/ijnp/pyz059.

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Abstract Background Treatment-resistant depression is among the most debilitating conditions in psychiatry. Recent studies have associated alterations in white matter microstructure measured with magnetic resonance imaging with poor antidepressant response. Therefore, the extent to which electroconvulsive therapy, the most effective therapeutic option for treatment-resistant depression, affects white matter microstructure warrants investigation. Methods A total 13 patients suffering from severe unipolar treatment-resistant depression underwent magnetic resonance imaging with a diffusion tensor

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Queiroz, J., J. Oliveira, A. Maia, et al. "White matter disconnection and decreased functional connectivity between orbitofrontal cortex and the contralateral temporo-occipital cortex in adults with obsessive compulsive disorder." European Psychiatry 64, S1 (2021): S135—S136. http://dx.doi.org/10.1192/j.eurpsy.2021.375.

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IntroductionObsessive compulsive disorder (OCD) affects 2-3% of the general population. The neurobiology of OCD has been linked to dysfunction of cortico-striatal circuits connecting the orbitofrontal (OFC) to the striatum. Recently, this loop has become an approved target for non-invasive neuromodulatory treatment of OCD.ObjectivesTo explore structural and functional connectivity of the OFC in OCD subjects and healthy controls.Methods14 OCD patients and 12 age/sex-matched controls underwent magnetic resonance imaging (MRI) (3T-Philips scanner) for diffusion tensor imaging (DTI) and resting st

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Messina, Roberta, Maria A. Rocca, Bruno Colombo, et al. "White matter microstructure abnormalities in pediatric migraine patients." Cephalalgia 35, no. 14 (2015): 1278–86. http://dx.doi.org/10.1177/0333102415578428.

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Background Diffusion tensor (DT) magnetic resonance imaging (MRI) provides several quantities with the potential to disclose white matter (WM) microstructural abnormalities. We explored alterations of WM architecture in pediatric migraine patients using DT MRI and two different methods of analysis. Methods Dual-echo and DT MRI scans were acquired from 15 pediatric migraine patients and 15 age-matched controls. Whole-brain voxel-wise comparisons of WM DT MRI abnormalities were performed using tract-based-spatial-statistics (TBSS). A DT probabilistic tractography analysis was also run. Results B

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Nucci, Carlo, Francesco Garaci, Simone Altobelli, et al. "Diffusional Kurtosis Imaging of White Matter Degeneration in Glaucoma." Journal of Clinical Medicine 9, no. 10 (2020): 3122. http://dx.doi.org/10.3390/jcm9103122.

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Glaucoma is an optic neuropathy characterized by death of retinal ganglion cells and loss of their axons, progressively leading to blindness. Recently, glaucoma has been conceptualized as a more diffuse neurodegenerative disorder involving the optic nerve and also the entire brain. Consistently, previous studies have used a variety of magnetic resonance imaging (MRI) techniques and described widespread changes in the grey and white matter of patients. Diffusion kurtosis imaging (DKI) provides additional information as compared with diffusion tensor imaging (DTI), and consistently provides high

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Bisecco, Alvino, Giuseppina Caiazzo, Alessandro d’Ambrosio, et al. "Fatigue in multiple sclerosis: The contribution of occult white matter damage." Multiple Sclerosis Journal 22, no. 13 (2016): 1676–84. http://dx.doi.org/10.1177/1352458516628331.

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Background: A functional cortico-subcortical disconnection has been recognized in fatigued multiple sclerosis (MS) patients. Normal appearing white matter (NAWM) damage might contribute to the abovementioned disconnectivity. Objectives: To assess the relationship between fatigue and microstructural NAWM damage in relapsing-remitting (RR) MS. Methods: Sixty RRMS patients and 29 healthy controls (HC) underwent a magnetic resonance imaging (MRI) protocol including diffusion tensor imaging (DTI). Patients with a mean Fatigue Severity Scale (FSS) score ⩾ 4 were considered fatigued (fatigued MS (F-M

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Tay, S. H., M. Stephenson, N. A. Allameen, S. Narayanan, B. Lee, and A. Mak. "POS0763 A MULTIMODAL MAGNETIC RESONANCE IMAGING STUDY OF COGNITIVE FUNCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS: A MACHINE LEARNING APPROACH." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 668.1–668. http://dx.doi.org/10.1136/annrheumdis-2022-eular.3452.

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BackgroundSystemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that can affect the central nervous system. Cognitive dysfuncion is the most common neuropsyhiatric event in SLE patients, yet it is also one of the hardest to diagnose.ObjectivesTo investigate if multimodal imaging to assess anatomical magnetic resonance imaging (MRI) abnormalities in the brains of SLE patients can predict cognitive function.MethodsSubjects underwent voxel-based morphometry (VBM), magnetization transfer imaging (MTI), and dynamic contrast-enhanced (DCE) MRI. Automated Neuropsychological Assessme

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Königs, Marsh, Petra JW Pouwels, LW Ernest van Heurn, et al. "Relevance of neuroimaging for neurocognitive and behavioral outcome after pediatric traumatic brain injury." Brain Imaging and Behavior 12, no. 1 (2017): 29–43. http://dx.doi.org/10.1007/s11682-017-9673-3.

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Abstract This study aims to (1) investigate the neuropathology of mild to severe pediatric TBI and (2) elucidate the predictive value of conventional and innovative neuroimaging for functional outcome. Children aged 8–14 years with trauma control (TC) injury (n = 27) were compared to children with mild TBI and risk factors for complicated TBI (mildRF+, n = 20) or moderate/severe TBI (n = 17) at 2.8 years post-injury. Neuroimaging measures included: acute computed tomography (CT), volumetric analysis on post-acute conventional T1-weighted magnetic resonance imaging (MRI) and post-acute diffusio

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Pelizzari, Laura, Marta Cazzoli, Susanna Lipari, et al. "Mid-term MRI evaluation reveals microstructural white matter alterations in COVID-19 fully recovered subjects with anosmia presentation." Therapeutic Advances in Neurological Disorders 15 (January 2022): 175628642211119. http://dx.doi.org/10.1177/17562864221111995.

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Background: Little is still known about the mid/long-term effects of coronavirus disease 2019 (COVID-19) on the brain, especially in subjects who have never been hospitalized due to the infection. In this neuroimaging exploratory study, we analyzed the medium-term effect of COVID-19 on the brain of people who recovered from COVID-19, experienced anosmia during the acute phase of the disease, and have never been hospitalized due to SARS-Co-V-2 infection. Methods: Forty-three individuals who had (COV+, n = 22) or had not (COV−, n = 21) been infected with SARS-Co-V-2 were included in the study; t

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Siasios, Ioannis, Eftychia Z. Kapsalaki, Kostas N. Fountas, et al. "The role of diffusion tensor imaging and fractional anisotropy in the evaluation of patients with idiopathic normal pressure hydrocephalus: a literature review." Neurosurgical Focus 41, no. 3 (2016): E12. http://dx.doi.org/10.3171/2016.6.focus16192.

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OBJECTIVE Diffusion tensor imaging (DTI) for the assessment of fractional anisotropy (FA) and involving measurements of mean diffusivity (MD) and apparent diffusion coefficient (ADC) represents a novel, MRI-based, noninvasive technique that may delineate microstructural changes in cerebral white matter (WM). For example, DTI may be used for the diagnosis and differentiation of idiopathic normal pressure hydrocephalus (iNPH) from other neurodegenerative diseases with similar imaging findings and clinical symptoms and signs. The goal of the current study was to identify and analyze recently publ

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Nguyen, John Quan, Tara Riddle, Sharon Chao, et al. "Microstructural Alterations of White Matter Associated With Colorectal Cancer-Related Cognitive Impairment." JCO Global Oncology 10, Supplement_1 (2024): 121–22. http://dx.doi.org/10.1200/go-24-99000.

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PURPOSE Colorectal cancer survivors exhibit impairments in information processing and working memory with no significantly added effects from adjuvant therapy (PMID: 26527785). Little is known regarding its neural mechanism, which greatly impedes the development of effective therapies. White matter (WM) is an area of interest as it is the predominant tissue that facilitates communication between different brain regions and from which damage could be debilitating. Here, we utilize 7T magnetic resonance diffusion tensor imaging (DTI) to investigate WM integrity and its association with colorecta

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Seitz, Johanna, Monica Lyons, Leila Kushan, et al. "M155. RECIPROCAL CHANGES IN WHITE MATTER MICROSTRUCTURE IN 22Q11.2 DELETION AND DUPLICATION SYNDROME." Schizophrenia Bulletin 46, Supplement_1 (2020): S194—S195. http://dx.doi.org/10.1093/schbul/sbaa030.467.

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Abstract Background The 22q11.2 deletion syndrome is a neurogenetic disorder that is associated with both physical anomalies and neurocognitive impairments. Deletion carriers have a greatly elevated risk of developing schizophrenia (SCZ); as such, it offers a compelling ‘high-penetrance’ model to explore the neuropathology of SCZ risk. Indeed, widespread structural alterations of both gray and white matter have been reported for 22q11.2 deletion carriers. Interestingly, there are also cases of duplications at the same gene locus. While less is known about the phenotype associated with 22q11.2

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Li, Dongyun, Lianni Mei, Huiping Li, et al. "Brain structural alterations in young girls with Rett syndrome: A voxel-based morphometry and tract-based spatial statistics study." Frontiers in Neuroinformatics 16 (September 8, 2022). http://dx.doi.org/10.3389/fninf.2022.962197.

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Rett syndrome (RTT) is a neurodevelopmental disorder caused by loss-of-function variants in the MECP2 gene, currently with no cure. Neuroimaging is an important tool for obtaining non-invasive structural and functional information about the in vivo brain. Multiple approaches to magnetic resonance imaging (MRI) scans have been utilized effectively in RTT patients to understand the possible pathological basis. This study combined developmental evaluations with clinical severity, T1-weighted imaging, and diffusion tensor imaging, aiming to explore the structural alterations in cohorts of young gi

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Schröder, Yvonne, Daniela Michelle Hohmann, Tina Meller, et al. "Associations of subclinical autistic-like traits with brain structural variation using diffusion tensor imaging and voxel-based morphometry." European Psychiatry 64, no. 1 (2021). http://dx.doi.org/10.1192/j.eurpsy.2021.15.

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Abstract Background Previous case–control studies of autistic spectrum disorder (ASD) have identified altered brain structure such as altered frontal and temporal cortex volumes, or decreased fractional anisotropy (FA) within the inferior fronto-occipital fasciculus in patients. It remains unclear whether subclinical autistic-like traits might also be related to variation in these brain structures. Methods In this study, we analyzed magnetic resonance imaging (MRI) data of 250 psychiatrically healthy subjects phenotyped for subclinical autistic-like traits using the Autism Spectrum Quotient (A

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Jung, Hye-Yeon, Chongwon Pae, Iseul An, et al. "A multimodal study regarding neural correlates of the subjective well-being in healthy individuals." Scientific Reports 12, no. 1 (2022). http://dx.doi.org/10.1038/s41598-022-18013-1.

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AbstractAlthough happiness or subjective well-being (SWB) has drawn much attention from researchers, the precise neural structural correlates of SWB are generally unknown. In the present study, we aimed to investigate the associations between gray matter (GM) volumes, white matter (WM) microstructures, and SWB in healthy individuals, mainly young adults using multimodal T1 and diffusion tensor imaging studies. We enrolled 70 healthy individuals using magnetic resonance imaging. We measured their SWB using the Concise Measure of Subjective Well-Being. Voxel-wise statistical analysis of GM volum

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Wan, Yu, Churan Sun, Mingfeng Fan, et al. "Exploring Psychological Factors and Brain Alterations in Functional Anorectal Pain Patients: Insights From Multimodal Magnetic Resonance Imaging Investigations." Neurogastroenterology & Motility, February 3, 2025. https://doi.org/10.1111/nmo.15017.

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ABSTRACTBackgroundFunctional anorectal pain (FAP) is classified as one of the disorders of gut‐brain interaction (DGBI). It involves the impairments of anorectal afferents and disrupted gut‐brain communication. However, neuroimaging studies focused on FAP are lacking.MethodsA total of 25 FAP patients and 18 healthy controls (HC) underwent structural magnetic resonance imaging (MRI), diffusion tensor imaging (DTI), resting‐state functional MRI (rs‐fMRI) scans, and collection of demographic data, mental health assessment scales and pain assessment questionnaires. Voxel‐based morphometry (VBM), t

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Hadaya, Laila, Konstantina Dimitrakopoulou, Lucy D. Vanes, et al. "Parsing brain-behavior heterogeneity in very preterm born children using integrated similarity networks." Translational Psychiatry 13, no. 1 (2023). http://dx.doi.org/10.1038/s41398-023-02401-w.

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AbstractVery preterm birth (VPT; ≤32 weeks’ gestation) is associated with altered brain development and cognitive and behavioral difficulties across the lifespan. However, heterogeneity in outcomes among individuals born VPT makes it challenging to identify those most vulnerable to neurodevelopmental sequelae. Here, we aimed to stratify VPT children into distinct behavioral subgroups and explore between-subgroup differences in neonatal brain structure and function. 198 VPT children (98 females) previously enrolled in the Evaluation of Preterm Imaging Study (EudraCT 2009-011602-42) underwent Ma

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Zitser, Jennifer, Melis Anatürk, Enikő Zsoldos, et al. "Sleep duration over 28 years, cognition, gray matter volume, and white matter microstructure: a prospective cohort study." Sleep 43, no. 5 (2020). http://dx.doi.org/10.1093/sleep/zsz290.

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Abstract Study Objectives To examine the association between sleep duration trajectories over 28 years and measures of cognition, gray matter volume, and white matter microstructure. We hypothesize that consistently meeting sleep guidelines that recommend at least 7 hours of sleep per night will be associated with better cognition, greater gray matter volumes, higher fractional anisotropy, and lower radial diffusivity values. Methods We studied 613 participants (age 42.3 ± 5.03 years at baseline) who self-reported sleep duration at five time points between 1985 and 2013, and who had cognitive

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Oh, Dae Jong, Ji-Jung Jung, Seong A. Shin, et al. "Brain Structural Alterations, Diabetes Biomarkers, and Cognitive Performance in Older Adults With Dysglycemia." Frontiers in Neurology 12 (October 28, 2021). http://dx.doi.org/10.3389/fneur.2021.766216.

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Despite the high risk of dementia in older adults with type 2 diabetes, the neuroanatomical correlates of cognitive dysfunction that are particularly affected by diabetes are not well characterized. This study is aimed to examine the structural brain alterations in dysglycemic older adults. Using voxel-based morphometric and tract-based spatial statistics, we examined changes in gray matter volume, white matter volume, and microstructural integrity in older adults with prediabetes and diabetes. We also assessed the correlation of these structural changes with diabetes biomarkers and cognitive

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Feis, Rogier A., Mark J. R. J. Bouts, Elise G. P. Dopper, et al. "Multimodal MRI of grey matter, white matter, and functional connectivity in cognitively healthy mutation carriers at risk for frontotemporal dementia and Alzheimer's disease." BMC Neurology 19, no. 1 (2019). http://dx.doi.org/10.1186/s12883-019-1567-0.

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Abstract Background Frontotemporal dementia (FTD) and Alzheimer’s disease (AD) are associated with divergent differences in grey matter volume, white matter diffusion, and functional connectivity. However, it is unknown at what disease stage these differences emerge. Here, we investigate whether divergent differences in grey matter volume, white matter diffusion, and functional connectivity are already apparent between cognitively healthy carriers of pathogenic FTD mutations, and cognitively healthy carriers at increased AD risk. Methods We acquired multimodal magnetic resonance imaging (MRI)

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Gallingani, Chiara, Chiara Carbone, Davide Salvatori, et al. "Right temporal variant frontotemporal dementia: a multimodal MRI analysis." Alzheimer's & Dementia 20, S2 (2024). https://doi.org/10.1002/alz.090317.

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AbstractBackgroundRight temporal variant frontotemporal dementia (rtvFTD), a new recognized entity among the FTD‐spectrum, is characterized by right anterior temporal lobe (rATL) atrophy and a peculiar clinical presentation, involving face and emotions recognition, memory, and naming deficits and behavioral disturbances. Clinical diagnosis is challenging, since rtvFTD shares features with both the behavioral variant FTD (bvFTD) and the semantic variant primary progressive aphasia (svPPA), and there is no consensus yet on its designation and characterization. Although rATL neurodegeneration is

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Nakaya, Moto, Noriko Sato, Hiroshi Matsuda, et al. "Assessment of Gray Matter Microstructural Alterations in Alzheimer’s Disease by Free Water Imaging." Journal of Alzheimer's Disease, May 15, 2024, 1–13. http://dx.doi.org/10.3233/jad-231416.

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Background: Cortical neurodegenerative processes may precede the emergence of disease symptoms in patients with Alzheimer’s disease (AD) by many years. No study has evaluated the free water of patients with AD using gray matter-based spatial statistics. Objective: The aim of this study was to explore cortical microstructural changes within the gray matter in AD by using free water imaging with gray matter-based spatial statistics. Methods: Seventy-one participants underwent multi-shell diffusion magnetic resonance imaging, 11C-Pittsburgh compound B positron emission tomography, and neuropsycho

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Jun Lee, Sung, Min Son Kim, and Sung Ho Jang. "White Matter Abnormalities in Spontaneous Subarachnoid Hemorrhage." Stroke 51, no. 9 (2020). http://dx.doi.org/10.1161/strokeaha.120.029996.

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Background and Purpose: We investigated white matter abnormalities in patients with spontaneous subarachnoid hemorrhage following aneurysmal rupture, by using tract-based spatial statistics. Methods: Sixteen patients with spontaneous subarachnoid hemorrhage due to aneurysmal rupture and 18 age- and sex-matched healthy control subjects were recruited. Voxel-wise statistical analysis of fractional anisotropy data was performed by using tract-based spatial statistics as implemented in the Functional Magnetic Resonance Imaging of the Brain Software Library. We calculated mean fractional anisotropy

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Andrews, Derek Sayre, Joshua K. Lee, Marjorie Solomon, Sally J. Rogers, David G. Amaral, and Christine Wu Nordahl. "A diffusion-weighted imaging tract-based spatial statistics study of autism spectrum disorder in preschool-aged children." Journal of Neurodevelopmental Disorders 11, no. 1 (2019). http://dx.doi.org/10.1186/s11689-019-9291-z.

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Abstract Background The core symptoms of autism spectrum disorder (ASD) are widely theorized to result from altered brain connectivity. Diffusion-weighted magnetic resonance imaging (DWI) has been a versatile method for investigating underlying microstructural properties of white matter (WM) in ASD. Despite phenotypic and etiological heterogeneity, DWI studies in majority male samples of older children, adolescents, and adults with ASD have largely reported findings of decreased fractional anisotropy (FA) across several commissural, projection, and association fiber tracts. However, studies in

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Yu, Li-qing, Hao Ma, Lian-ying Cao, and Yu-lu Zhou. "Noninvasive Evaluation of Acupuncture-Induced Cortical Plasticity in Advanced Rehabilitation of Facial Paralysis." Journal of Craniofacial Surgery, August 26, 2024. http://dx.doi.org/10.1097/scs.0000000000010544.

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Objective: Facial paralysis (FP), which resulted from head and neck cancer resection, significantly impacts patients’ quality of life. Traditional assessments rely on subjective evaluations and electromyography, whereas functional magnetic resonance imaging offers a noninvasive alternative for enhanced rehabilitation. Acupuncture has shown promise in promoting cerebral cortex reorganization, yet the precise relationship between acupuncture-induced structural and functional changes remains unclear, necessitating further investigation into therapeutic mechanisms. Methods: Fifty-five patients aff

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Vieira, Rita, Ana Coelho, Joana Reis, et al. "White Matter Microstructure Alterations Associated With Paroxetine Treatment Response in Major Depression." Frontiers in Behavioral Neuroscience 15 (July 22, 2021). http://dx.doi.org/10.3389/fnbeh.2021.693109.

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More than one-third of depressive patients do not achieve remission after the first antidepressant treatment. The “watch and wait” approach used to find the most effective antidepressant leads to an increased personal, social, and economic burden in society. In order to overcome this challenge, there has been a focus on studying neural biomarkers associated with antidepressant response. Diffusion tensor imaging measures have shown a promising role as predictors of antidepressant response by pointing to pretreatment differences in the white matter microstructural integrity between future respon

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Viher, Petra Verena, Katharina Stegmayer, Tobias Bracht, et al. "Neurological Soft Signs Are Associated With Altered White Matter in Patients With Schizophrenia." Schizophrenia Bulletin, August 6, 2021. http://dx.doi.org/10.1093/schbul/sbab089.

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Abstract Neurological soft signs (NSS) are related to grey matter and functional brain abnormalities in schizophrenia. Studies in healthy subjects suggest, that NSS are also linked to white matter. However, the association between NSS and white matter abnormalities in schizophrenia remains to be elucidated. The present study investigated, if NSS are related to white matter alterations in patients with schizophrenia. The total sample included 42 healthy controls and 41 patients with schizophrenia. We used the Neurological Evaluation Scale (NES), and we acquired diffusion weighted magnetic reson

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Tang, Xiangyong, Yanzi Chen, Hui Tan, et al. "Micro- and macro-changes in early-stage type 2 diabetes mellitus without cognitive impairment: a diffusion tensor imaging (DTI) and surface-based morphometry (SBM) study." Frontiers in Neurology 14 (July 5, 2023). http://dx.doi.org/10.3389/fneur.2023.1115634.

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IntroductionBrain structure and function changes are considered major brain damages in type 2 diabetes mellitus (T2DM), which likely has a close relationship with cognitive impairment. Many previous studies have shown by using brain structural and functional magnetic resonance imaging (MRI) methods that brain white and gray matter are damaged in T2DM, leading to cognitive impairment. Researches neglected patients of T2DM without cognitive dysfunction might also have brain changes.MethodsIn this study, subjects with early stage T2DM with no cognitive dysfunction were enrolled to detect brain da

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Romaniuk, Madeline, Ying Xia, Gina Fisher, et al. "The relationship between chronic PTSD, cortical volumetry and white matter microstructure among Australian combat veterans." Military Medical Research 9, no. 1 (2022). http://dx.doi.org/10.1186/s40779-022-00413-z.

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Abstract Background Posttraumatic stress disorder (PTSD) has been associated with volumetric and white matter microstructural changes among general and veteran populations. However, regions implicated have greatly varied and often conflict between studies, potentially due to confounding comorbidities within samples. This study compared grey matter volume and white matter microstructure among Australian combat veterans with and without a lifetime diagnosis of PTSD, in a homogenous sample assessed for known confounding comorbidities. Methods Sixty-eight male trauma-exposed veterans (16 PTSD-diag

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Shuster, Ethan, Amy E. Miles, Lindsay K. Heyland, et al. "Neuroimaging features of depression–frailty phenotype in older adults: a pilot study." International Psychogeriatrics, February 20, 2023, 1–7. http://dx.doi.org/10.1017/s1041610223000066.

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ABSTRACT Objective: Frailty and late-life depression (LLD) often coexist and share several structural brain changes. We aimed to study the joint effect LLD and frailty have on brain structure. Design: Cross-sectional study Setting: Academic Health Center Participants: Thirty-one participants (14 LLD+Frail and 17 Never-depressed+Robust) Measurement: LLD was diagnosed by a geriatric psychiatrist according to the Diagnostic and Statistical Manual of Mental Disorders 5th edition for single episode or recurrent major depressive disorder without psychotic features. Frailty was assessed using the FRA

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Xiong, Ying, Wen Shao, Juan Wang, Shaolin Yang, Wenzhen Zhu, and Qiang Zhang. "Application of neurite orientation dispersion and density imaging in characterizing brain microstructural changes in classical trigeminal neuralgia and a comparison between the left and right sides." Pain, May 6, 2025. https://doi.org/10.1097/j.pain.0000000000003614.

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Abstract Diffusion tensor imaging can detect brain white matter changes in classical trigeminal neuralgia (TN). However, it lacks specificity for individual tissue microstructural features, such as neurite density, orientation dispersions, and extracellular edema. Neurite orientation dispersion and density imaging (NODDI), a novel diffusion magnetic resonance imaging (MRI) technique, can provide these distinct indices. We characterized brain microstructural alterations in patients with unilateral TN using NODDI and compared the difference between left- and right-side TN (LTN and RTN, respectiv

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Kawadler, Jamie M., Fenella J. Kirkham, Jonathan D. Clayden, et al. "White Matter Damage Relates to Oxygen Saturation in Children With Sickle Cell Anemia Without Silent Cerebral Infarcts." May 13, 2015. https://doi.org/10.1161/strokeaha.115.008721.

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Background and Purpose— Sickle cell anemia is associated with compromised oxygen-carrying capability of hemoglobin and a high incidence of overt and silent stroke. However, in children with no evidence of cerebral infarction, there are changes in brain morphometry relative to healthy controls, which may be related to chronic anemia and oxygen desaturation. Methods— A whole-brain tract-based spatial statistics analysis was carried out in 25 children with sickle cell anemia with no evidence of abnormality on T2-weighted magnetic resonance imaging (13 male, age range: 8–18 years) and 14 age- and

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Koevoets, Emmie W., Sanne B. Schagen, Anne M. May, et al. "Effect of physical exercise on white matter microstructure in chemotherapy-treated breast cancer patients: a randomized controlled trial (PAM study)." Brain Imaging and Behavior, January 13, 2025. https://doi.org/10.1007/s11682-024-00965-9.

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Abstract Physical exercise is a promising intervention to improve brain white matter integrity. In the PAM study, exercise intervention effects on white matter integrity were investigated in breast cancer patients. Chemotherapy-treated breast cancer patients with cognitive problems were randomized 2–4 years post-diagnosis to an exercise (n = 91) or control group (n = 90). The 6-month exercise intervention consisted of four hours/week of aerobic and resistance training. White matter integrity was measured at baseline and 6-month follow-up with fractional anisotropy (FA) and mean diffusivity (MD

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Gan, Caiting, Lina Wang, Min Ji, et al. "Abnormal interhemispheric resting state functional connectivity in Parkinson’s disease patients with impulse control disorders." npj Parkinson's Disease 7, no. 1 (2021). http://dx.doi.org/10.1038/s41531-021-00205-7.

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AbstractImpulse control disorders (ICD) in Parkinson’s disease (PD) might be attributed to misestimate of rewards or the failure to curb inappropriate choices. The mechanisms underlying ICD were reported to involve the lateralization of monoamine network. Our objective was to probe the significant role of lateralization in the pathogenesis of ICD. Twenty-one PD patients with ICD (PD-ICD), thirty-three without ICD (PD-no ICD), and thirty-seven healthy controls (HCs) were recruited and performed T1-weighted, diffusion tensor imaging (DTI) scans and resting state functional magnetic resonance ima

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Gollion, Cédric, Håkan Ashina, Rune Häckert Christensen, et al. "Intact white matter in adults with migraine: A REFORM MRI study." Cephalalgia 45, no. 5 (2025). https://doi.org/10.1177/03331024251339423.

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Background Diffusion tensor imaging (DTI) provides valuable insights into the white matter integrity of people with migraine. The present study compares the microstructural white matter integrity between a large sample of people with migraine and healthy controls, as well as across different migraine subtypes. Methods This cross-sectional case-control study included adults with migraine and age- and sex-matched healthy controls. Each participant and control underwent a single brain magnetic resonance imaging session, including DTI, to assess microstructural white matter integrity using tract-b

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Trò, Rosella, Monica Roascio, Domenico Tortora, et al. "Multi-view fusion of diffusion MRI microstructural models: a preterm birth study." Frontiers in Neuroscience 18 (December 20, 2024). https://doi.org/10.3389/fnins.2024.1480735.

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ObjectiveHigh Angular Resolution Diffusion Imaging (HARDI) models have emerged as a valuable tool for investigating microstructure with a higher degree of detail than standard diffusion Magnetic Resonance Imaging (dMRI). In this study, we explored the potential of multiple advanced microstructural diffusion models for investigating preterm birth in order to identify non-invasive markers of altered white matter development.ApproachRather than focusing on a single MRI modality, we studied on a compound of HARDI techniques in 46 preterm babies studied on a 3T scanner at term-equivalent age and in

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Breit, Sigrid, Niklaus Denier, Nicolas Mertse, et al. "The neurobiology of motivational anhedonia in patients with depression." Brain Imaging and Behavior, March 31, 2025. https://doi.org/10.1007/s11682-025-00999-7.

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Abstract Anhedonia is a core feature of depression. It contains a consummatory and a motivational aspect. Whilst much neuroimaging research in patients with depression focused on the consummatory aspect of anhedonia, less is known about its motivational aspect. This study aimed to explore the neurobiology of networks related to motivational anhedonia. Thirty-eight patients with major depressive disorder (MDD) and 19 healthy controls underwent diffusion-weighted and resting state functional magnetic resonance imaging (rs-fMRI). For assessment of motivational anhedonia, we summed the values of t

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Jin, Chaoyang, Shouliang Qi, Yueyang Teng, et al. "Integrating Structural and Functional Interhemispheric Brain Connectivity of Gait Freezing in Parkinson's Disease." Frontiers in Neurology 12 (April 15, 2021). http://dx.doi.org/10.3389/fneur.2021.609866.

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Freezing of gait (FOG) has devastating consequences for patients with Parkinson's disease (PD), but the underlying pathophysiological mechanism is unclear. This was investigated in the present study by integrated structural and functional connectivity analyses of PD patients with or without FOG (PD FOG+ and PD FOG–, respectively) and healthy control (HC) subjects. We performed resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging of 24 PD FOG+ patients, 37 PD FOG– patients, and 24 HCs. Tract-based spatial statistics was applied to identify white matter (WM) ab

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