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1

Xu, Yuan, Shan Cao, Shu-fei Wang, Xin-li Hou, Si-si Guo, and Xiao-jun Gou. "Comparative efficacy and safety of Chinese patent medicines of acute ischemic stroke: A network meta-analysis." Medicine 102, no. 42 (2023): e35129. http://dx.doi.org/10.1097/md.0000000000035129.

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Background: Acute ischemic stroke (AIS) is characterized by high morbidity, disability, mortality, recurrence, and economic burden. Clinical trials have demonstrated that the clinical efficacy of combining oral Chinese patent medicines (CPMs) with chemical drugs (CDs) is better than that of CDs alone. In this study, we performed a network meta-analysis (NMA) of RCTs to assess the efficacy of different CPMs in combination with CDs in the treatment of AIS. Methods: Search 6 databases from the beginning to January 10, 2023. The Cochrane Risk of Bias tool assessed the methodological quality of the
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Ren, YongLi, Jiao Mou, YueJie Chu, Ming Ren, HanBo Cui, and XiaoJuan Xu. "The effect of Xin-Nao-Xue-Mai-Ning on SD rats with hypothyroidism and IRE1-XBP1 signaling." Microenvironment and Microecology Research 3, no. 4 (2021): 17. http://dx.doi.org/10.53388/mmr2021017.

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Hung, I. Ling, Chia-Jung Chung, Wen-Long Hu, et al. "Chinese Herbal Medicine as an Adjunctive Therapy Improves the Survival Rate of Patients with Ischemic Heart Disease: A Nationwide Population-Based Cohort Study." Evidence-Based Complementary and Alternative Medicine 2022 (July 4, 2022): 1–10. http://dx.doi.org/10.1155/2022/5596829.

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Background. Ischemic heart disease (IHD) related to cardiovascular or cerebrovascular disease is the leading cause of mortality and an important issue of public health worldwide. The cost of long-term healthcare for IHD patients may result in a huge financial burden. Objectives. To analyze the medical expenditure incurred for and survival of IHD patients treated with Chinese herbal medicine (CHM) and Western medicine. Methods. Subjects were randomly selected from the National Health Insurance Research Database in Taiwan. The Cox proportional hazards regression model, Kaplan–Meier estimator, lo
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Zhou, Feng, Zhengtao Li, Yajing Liu, et al. "Abstract 3474: Identification of the selective CBL-b inhibitors which effectively prevent T cells from exhaustion and demonstrate synergistic anti-tumor activity in combination with an anti-PD1 antibody." Cancer Research 83, no. 7_Supplement (2023): 3474. http://dx.doi.org/10.1158/1538-7445.am2023-3474.

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Abstract The E3 ubiquitin ligase Casitas B-lineage lymphoma b (Cbl-b) is a member of the highly conserved family of Cbl (casitas b-lineage lymphoma) proteins. CBL-b is widely expressed in immune cells and plays as a “gate keeper” to negatively regulate the activation of immune cells. Engagement of TCR/BCR triggers the Cbl-b-mediated ubiquitination and degradation of the key components in TCR axis, such as Vav1 and PLCγ, and consequently attenuates TCR/BCR signal axis which finally results in T/B cells exhaustion. Besides, Cbl-b was reported to negatively regulate the activation of dendritic ce
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Xue, Jie, Keyu Li, Poonam Yakkundi, et al. "Abstract 6726: Costimulatory IgM T-cell engagers with enhanced and durable cytotoxicity." Cancer Research 84, no. 6_Supplement (2024): 6726. http://dx.doi.org/10.1158/1538-7445.am2024-6726.

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Abstract T-cell engagers (TCEs) have established therapeutic effect in treatment of various cancers by harnessing the power of the immune system against tumors in a targeted manner. IgM-based TCEs may offer high avidity, specificity, and safety advantages over other modalities because of their multivalent architecture and unique positioning of the CD3 binding domain on the J-chain. We have built a costimulatory IgM TCE platform that engages both signal 1 and signal 2 on T-cells, with the goal of enabling their optimal activation and survival for more robust and durable cytotoxic activity. Mult
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Senanayake, Indunil C., Tong-Tong Lian, Xiao-Min Mai, et al. "Taxonomy and phylogeny of Amphisphaeria acericola sp. nov. from Italy." Phytotaxa 403, no. 4 (2019): 285–92. https://doi.org/10.11646/phytotaxa.403.4.2.

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Senanayake, Indunil C., Lian, Tong-Tong, Mai, Xiao-Min, Camporesi, Erio, Zeng, Yu-Jia, Tian, Sheng-Li, Xie, Ning (2019): Taxonomy and phylogeny of Amphisphaeria acericola sp. nov. from Italy. Phytotaxa 403 (4): 285-292, DOI: 10.11646/phytotaxa.403.4.2, URL: http://dx.doi.org/10.11646/phytotaxa.403.4.2
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Mai, Hai-Qiang, Ya-Qian Han, Guo-Wu Wu, et al. "Abstract CT113: A dose-exploring, randomized, open-label, Phase I study for toripalimab subcutaneous injection in patients with advanced nasopharyngeal carcinoma." Cancer Research 84, no. 7_Supplement (2024): CT113. http://dx.doi.org/10.1158/1538-7445.am2024-ct113.

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Abstract Background Toripalimab, a humanized IgG4K monoclonal antibody specific for PD-1, in combination with gemcitabine and cisplatin (GP) has been approved as a first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC) by the US FDA in October 2023. This is the first-in-human clinical trial (NCT05751486) to investigate the pharmacokinetics of toripalimab subcutaneous (SC) formulation in RM-NPC and determine the appropriate subcutaneous administration regimen for subsequent clinical trials. Methods Patients with histologically confirmed RM-NPC and without previously
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SHELAH, SAHARON, and OTMAR SPINAS. "MAD SPECTRA." Journal of Symbolic Logic 80, no. 3 (2015): 901–16. http://dx.doi.org/10.1017/jsl.2015.9.

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AbstractThe mad spectrum is the set of all cardinalities of infinite maximal almost disjoint families on ω. We treat the problem to characterize those sets ${\rm {\cal A}} $ which, in some forcing extension of the universe, can be the mad spectrum. We give a complete solution to this problem under the assumption $\vartheta ^{ < \vartheta } = \vartheta $, where $\vartheta = {\rm{min}}\left( {\rm {\cal A}} \right) $.
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Sang, Ernesto René, and Eva Maria Migliavacca. "Amor de devoção filiais (xiàoshùn) na família chinesa." TRAVESSIA - revista do migrante, no. 59 (December 10, 2007): 43–45. http://dx.doi.org/10.48213/travessia.i59.240.

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A filiação é, por definição, de início, um vínculo de natureza biológica. No entanto, interessa-nos a filiação como vínculo psicossocial colorido pela cultura, produto da humanização desse vínculo biológico tal como conscientizado pelo sujeito. Na literatura relacionada à família chinesa (Hsu, 1974, 1949, 1961; Mah, 1998; Chang, 1998; Tan, 1992; Wong, 1998; Xue, 2003; Yang, 1948; Zang, [s/d]; Osgood, 1975), seu modo de funcionamento obedece à doutrina confucionista, que tem como postulado importante o amor e a devoção filiais (xiàoshún) que regem as relações dentro da família chinesa. Será que
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Kan, Xiaoru, Nan Cheng, Jinghan Liu, Jiayue Wang, and Jun Chen. "Exploring the Prevention and Treatment of Epilepsy based on the Theory of Ambrosia." Journal of Contemporary Medical Practice 6, no. 9 (2024): 1–5. http://dx.doi.org/10.53469/jcmp.2024.06(09).01.

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The theory of "Fu Xie" is one of the important theories in traditional Chinese medicine, which guides the prevention and treatment of many diseases, including epilepsy. Epilepsy is a common neurological disease with complex etiology and diverse clinical manifestations. According to the theory of "Fu Xie", epilepsy is caused by factors such as liver wind, phlegm turbidity, dampness evil, and fire heat. Therefore, the key to treating epilepsy is to clear these pathogenic factors and regulate the body's physiological functions such as Qi, blood, Yin, and Yang. In Chinese medicine treatment, drugs
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Din, Riaz Ud, Salman Ahmed, Saddam Hussain Khan, Abdullah Albanyan, Julian Hoxha, and Bader Alkhamees. "A novel decision ensemble framework: Attention-customized BiLSTM and XGBoost for speculative stock price forecasting." PLOS ONE 20, no. 4 (2025): e0320089. https://doi.org/10.1371/journal.pone.0320089.

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Forecasting speculative stock prices is essential for effective investment risk management and requires innovative algorithms. However, the speculative nature, volatility, and complex sequential dependencies within financial markets present inherent challenges that necessitate advanced techniques. In this regard, a novel framework, ACB-XDE (Attention-Customized BiLSTM-XGB Decision Ensemble), is proposed for predicting the daily closing price of speculative stock Bitcoin-USD (BTC-USD). The proposed ACB-XDE framework integrates the learning capabilities of a customized Bi-directional Long Short-
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Nagy-Zombory, Piroska. "L'érémitisme en France et en Italie (XIe-XIVe s.). Sources et lieux. Pontignano, 5-7 mai 2000." Revue Mabillon 11 (January 2000): 306–9. http://dx.doi.org/10.1484/j.rm.2.305660.

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Colardelle, Michel, Claude Forrieres, Eric Verdel, Alain Ploquin, and Paul Merluzzo. "La métallurgie dans l'habitat fortifié de Colletière à Charavines (XIe siècle)." Le Monde alpin et rhodanien. Revue régionale d’ethnologie 24, no. 2 (1996): 135–47. http://dx.doi.org/10.3406/mar.1996.1603.

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14

Veg, Sebastian. "Quelle science pour quelle démocratie? Lu Xun et la littérature de fiction dans le mouvement du 4 mai." Annales. Histoire, Sciences Sociales 65, no. 2 (2010): 345–74. http://dx.doi.org/10.1017/s0395264900038555.

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RésuméLe mouvement du 4 mai 1919 est généralement associé aux appels en faveur de « Monsieur Science et Monsieur Démocratie » d’activistes comme Chen Duxiu, dont les théories restent souvent prisonnières d’une vision à la fois scientiste et instrumentale, conduisant directement du darwinisme social au marxisme. L’appel à la littérature comme vecteur de diffusion des idées nouvelles a cependant donné naissance à un autre courant de réflexion dont Lu Xun est le représentant central. Cet article cherche à montrer comment Lu Xun, dans ses nouvelles, a rejeté l’instrumentalisation aussi bien de la
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Turcan-Verkerk, Anne-Marie. "La théorisation progressive du cursus et sa terminologie entre le XIe siècle et la fin du XIVe siècle." Archivum Latinitatis Medii Aevi 73, no. 1 (2015): 179–259. http://dx.doi.org/10.3406/alma.2015.1175.

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Sono veramente esistite due scuole medievali di cursus, una scuola italiana caratterizzata da una terminologia sillabica, e una scuola orleanese che utilizzava une terminologia pseudometrica ? Questo contributo dimostra che all’origine la terminologia metrica era utilizzata da tutti per descrivere e percepire la musica del cursus del periodo intero, mentre la presentazione sillabica riguardava soltanto ciò che permetteva il successo di questo cursus, vale a dire la chiusa. Il senso della nozione di cursus cambia progressivamente nel corso del Duecento, ma non prima, e solo allora apparisce una
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Thị Mai Chanh, Nguyễn, and Bùi Thuỳ Linh. "A mad man’s diary by Lu Xun and the call to rescue." Journal of Science, Social Science 61, no. 2 (2016): 10–14. http://dx.doi.org/10.18173/2354-1067.2016-0002.

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Choi, Won-Jin, and Jeong-Seok Lee. "A Balanced Path-Following Approach to Course Change and Original Course Convergence for Autonomous Vessels." Journal of Marine Science and Engineering 12, no. 10 (2024): 1831. http://dx.doi.org/10.3390/jmse12101831.

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This paper proposes a novel path-following method for autonomous ships that optimizes overall performance by balancing course changes and convergence to the original route. The proposed method extends the line-of-sight (LOS) guidance law by dynamically adjusting key parameters based on the ship’s cross-track error (XTE) and the distance of new course considering maneuvering characteristics. By incorporating these maneuvering characteristics, the method enables more precise adjustments during course changes, improving overall path-following performance. Simulation results showed that the propos
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Acevedo, Javier, Robert Scheffel, Simon Wunderlich, et al. "Hardware Acceleration for RLNC: A Case Study Based on the Xtensa Processor with the Tensilica Instruction-Set Extension." Electronics 7, no. 9 (2018): 180. http://dx.doi.org/10.3390/electronics7090180.

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Random linear network coding (RLNC) can greatly aid data transmission in lossy wireless networks. However, RLNC requires computationally complex matrix multiplications and inversions in finite fields (Galois fields). These computations are highly demanding for energy-constrained mobile devices. The presented case study evaluates hardware acceleration strategies for RLNC in the context of the Tensilica Xtensa LX5 processor with the tensilica instruction set extension (TIE). More specifically, we develop TIEs for multiply-accumulate (MAC) operations for accelerating matrix multiplications in Gal
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Banu, P. K. Nizar, and S. Andrews. "Performance Analysis of Hard and Soft Clustering Approaches For Gene Expression Data." International Journal of Rough Sets and Data Analysis 2, no. 1 (2015): 58–69. http://dx.doi.org/10.4018/ijrsda.2015010104.

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Mining gene expression data is growing rapidly to predict gene expression patterns and assist clinicians in early diagnosis of tumor formation. Clustering gene expression data is the most important phase, helps in finding group of genes that are highly expressed and suppressed. This paper analyses the performance of most representative hard and soft off-line clustering algorithms: K-Means, Fuzzy C-Means, Self Organizing Maps (SOM) based clustering and Genetic Algorithm (GA) based clustering for brain tumor gene expression dataset. Clusters produced by the clustering algorithms are the indicati
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Chen, Yi-Xiu, Bing Han Huang, and Chuan-Pu Liu. "Rational Design of LixSiOy-Based Pre-SEI through Thermal-Evaporated Li-Metal Prelithiated SiOx Anode Enabling Extremely Stable and High-Rate Lithium Microbatteries." ECS Meeting Abstracts MA2024-01, no. 5 (2024): 711. http://dx.doi.org/10.1149/ma2024-015711mtgabs.

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Recently, silicon oxides families (SiOx) have been commercialized as high capacity anode materials growing rapidly owing to their natural resource abundance and low-cost.(1) However, both the poor electron/ionic conductivity, and quite low initial coulombic efficiency (ICE) (normally < 60%) limits the further development into next generation SiOx anodes. (2) To address these two critical issues, various pre-lithiation strategies have emerged and systematically investigated with significant progress.(3, 4) Here, we provide a facile approach to prelithiate SiOx films by optimizing RF power an
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Xu, Jia, and Jian Liu. "High-Entropy Strategy to Suppress Volumetric Strain and Enhance Diffusion Rate of Na3V2(PO4)2F3 Cathode for Durable and High-Areal-Capacity Zinc-Ion Battery Pouch Cells." ECS Meeting Abstracts MA2024-01, no. 17 (2024): 3040. http://dx.doi.org/10.1149/ma2024-01173040mtgabs.

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The burgeoning global environmental awareness and the escalating demand for renewable energy storage have intensified the critical need for next-generation battery technologies.1,2 In recent decades, there has been a sustained pursuit of grid-scale energy storage systems that balance practicality and efficiency. In this context, aqueous zinc-ion batteries (AZIBs) have emerged as a promising contender, driven by the distinct advantages of the 2.8-fold higher volumetric capacity (5849 mAh cm-3) of zinc metal over lithium metal (2062 mAh cm-3), and the use of non-toxic, cost-effective aqueous ele
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Xu, Shuhua, Jittima Weerachayaphorn, Shi-Ying Cai, Carol J. Soroka, and James L. Boyer. "Aryl hydrocarbon receptor and NF-E2-related factor 2 are key regulators of human MRP4 expression." American Journal of Physiology-Gastrointestinal and Liver Physiology 299, no. 1 (2010): G126—G135. http://dx.doi.org/10.1152/ajpgi.00522.2010.

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Multidrug resistance protein 4 (MRP4; ABCC4) is an ATP binding cassette transporter that facilitates the excretion of bile salt conjugates and other conjugated steroids in hepatocytes and renal proximal tubule epithelium. MRP4/Mrp4 undergoes adaptive upregulation in response to oxidative and cholestatic liver injury in human and animal models of cholestasis. However, the molecular mechanism of this regulation remains to be determined. The aryl hydrocarbon receptor (AhR) and NF-E2-related factor 2 (Nrf2) play important roles in protecting cells from oxidative stress. Here we examine the role of
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Zhu, Hengrui, Hui Li, Zhuo Li, et al. "Abstract 1789: Preclinical characterization of BGB-B3227, a MUC1 x CD16A bispecific engager, for the treatment of MUC1-expressing solid tumors." Cancer Research 85, no. 8_Supplement_1 (2025): 1789. https://doi.org/10.1158/1538-7445.am2025-1789.

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Abstract Background: MUC1 is frequently overexpressed in various human epithelial cancers, including NSCLC, gastrointestinal, breast, pancreatic, ovarian, and colon carcinomas. Despite the development of MUC1 targeted therapies, none have shown significant clinical efficacy. BGB-B3227, a novel bispecific antibody targeting MUC1 and CD16A, is designed to induce NK cell activation and subsequent cytotoxicity against MUC1-expressing tumor cells. Methods: The target binding activity of BGB-B3227 was characterized using biochemical and cell-based assays. The ability of BGB-B3227 to avoid the interf
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Šimon, V., C. Bartolini, A. Guarnieri, A. Piccioni, and D. Hanžl. "Outburst of the unique X-ray transient CI Cam and its impact on the system." Proceedings of the International Astronomical Union 2, S238 (2006): 447–48. http://dx.doi.org/10.1017/s1743921307005881.

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AbstractWe argue that the outburst of CI Cam (XTE J0421+560), probably containing a black hole, was caused by the thermal instability of the accretion disk. Applying the model of King & Ritter (1998), we obtain a realistic disk mass and radius. The differences from soft X-ray transients belonging to the low-mass X-ray binaries can be explained if the disk in CI Cam heats up an extended envelope and/or a strong jet is formed. We resolve several spectral components in the optical colors in quiescence after the outburst; they vary in a complicated way during a possible 1350 d cycle.We find in
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Nayak, Bishnu P., Meiguang Xiong, Yajuan Xue, et al. "Abstract 7532: NB005.1, a fully humanized anti-KLRG1 blocking mAb enhances effector function of human CD8 T-cells." Cancer Research 84, no. 6_Supplement (2024): 7532. http://dx.doi.org/10.1158/1538-7445.am2024-7532.

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Abstract Introduction: Immune checkpoint blockers (ICBs) have revolutionized treatment, enhancing survival and benefiting many patients. However, many patients fail to respond to the treatment, necessitating research for new targets and improved approaches. The Killer cell Lectin-like Receptor G1 (KLRG1), expressed on a subset of NK and T-cells harbors an immune receptor tyrosine-based inhibitory motif (ITIM) within its cytoplasmic domain, indicating its inhibitory function. On CD8+ T-cells, KLRG1 is expressed on highly differentiated antigen-specific effector memory T-cells (TEMs) and CD45RA+
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McKeague, Michelle L., Jason Lohmueller, Matthew T. Dracz, et al. "Abstract LB179: Patient-derived, vaccine-elicited, anti-MUC1 antibodies directly target tumor cells for elimination via multiple immune mechanisms." Cancer Research 82, no. 12_Supplement (2022): LB179. http://dx.doi.org/10.1158/1538-7445.am2022-lb179.

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Abstract During premalignant and malignant transformation, cells undergo antigenic changes that can be recognized by the immune system, and this can be leveraged both for immune prevention and therapy. One such change occurs with MUC1, or Mucin-1, a large variable number tandem repeat (VNTR)-containing transmembrane protein that is overexpressed and hypoglycosylated on a majority of precancerous and adenocarcinoma cells, including those of the colon, lung, breast, pancreas and ovaries. This tumor form of MUC1 is recognized by both cellular and humoral immunity. Healthy individuals at high risk
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Lee, Youn-Ki. "Understanding on the Reaction Pathway for Lithium Storage Behavior in Molybdenum Sulfides with Different Sulfur Configuration." ECS Meeting Abstracts MA2024-02, no. 2 (2024): 233. https://doi.org/10.1149/ma2024-022233mtgabs.

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Molybdenum disulfide (MoS2) has been considered as promising electrode materials in lithium-ion batteries (LIBs) due to its high theoretical capacity through conversion reactions (MoS2 + 4Li+ + 4e− ↔ Mo + 2Li2S) [1,2]. It is well-known that MoS2 electrode exhibits the intercalation of lithium-ions (167 mAh/g) between layers and the formation of lithium sulfide (669 and 1675 mAh/g) via conversion reaction. Considering these electrochemical reactions, it is speculated that the main capacity in MoS2 electrode originated from lithium sulfide (Li2S) reaction. Thus, research on molybdenum sulfides w
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Feng, Ru, and Thomas Graf. "Can Fibroblasts Be Reprogrammed into Macrophages?." Blood 108, no. 11 (2006): 443. http://dx.doi.org/10.1182/blood.v108.11.443.443.

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Abstract Previous work showed that B cell precursors can be reprogrammed into functional macrophages by the enforced expression of the bZip transcription factor C/EBPalpha. The efficient activation of myelomonocytic genes, such as Mac-1, required the co-operation with endogenous PU.1 (Xie et al. 2004), reflecting the fact that many myelomonocytic genes are regulated by a combination of the two transcription factors. We therefore asked: Is C/EBPa and PU.1 sufficient to convert non-hematopoietic cells into macrophages? To test this, NIH-3T3 cells were co-infected with PU.1-GFP and C/EBPa-hCD4 re
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Xie, Mingquan, Peter Li, Han Lu, et al. "Abstract 2880: TM4SF1 as a novel target for different modalities (mAb, bispecific ADC, targeted siRNA) for the treatment of different solid tumor cancers." Cancer Research 85, no. 8_Supplement_1 (2025): 2880. https://doi.org/10.1158/1538-7445.am2025-2880.

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Background: Transmembrane-4-L-six-family member-1 (TM4SF1) is a tetraspanin superfamily member that is overexpressed in cancers such as breast, colon, lung, liver, and prostate. A contributor to tumor development and progression, TM4SF1 participates in microdomains that regulate cancer cell migration and invasion via induction of the epithelial-mesenchymal transition, and angiogenesis. The overexpression of TM4SF1 makes it an attractive target for the developing novel treatments of GI tract cancers. Methods and Results: We have engineered an anti-TM4SF1 antibody that binds with nM affinity to
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Gallawa, Jessica Ruby, Jeffrey Ma, and Amy L. Prieto. "(Battery Student Slam 8 Award Winner) Evaluating Electrodeposited Tin and Antimony-Based Anodes for Sodium-Ion Batteries." ECS Meeting Abstracts MA2024-01, no. 5 (2024): 716. http://dx.doi.org/10.1149/ma2024-015716mtgabs.

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The widescale adaption of intermittent renewable energy sources, such as wind and solar, must be accompanied by a grid storage network to store energy when it is abundant and redistribute it as needed for on-demand use. Short-term storage in the form of rechargeable batteries is an attractive avenue for meeting these storage needs. The dominant technology in today’s market, the lithium-ion battery (LIB), is cost-prohibitive due to the need for rare-earth materials. Using the same working principle as LIBs, sodium-ion batteries (NIBs) utilize earth-abundant, low-cost sodium compounds instead of
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Ohyama, Hiroshi, Rintaro Mikata, Takeshi Ishihara, et al. "Reply to Xie S, Mai G. Comments on “Efficacy of Stone Density on Noncontrast Computed Tomography in Predicting the Outcome of Extracorporeal Shock Wave Lithotripsy for Patients With Pancreatic Stones” by Ohyama et al." Pancreas 45, no. 3 (2016): e5-e6. http://dx.doi.org/10.1097/mpa.0000000000000534.

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Feng, Shuo, Yucheng Fu, Lili Shi, Cassidy Anderson, and Dongping Lu. "Low-Tortuous and Dense Electrode for High-Energy Lithium-Sulfur Batteries." ECS Meeting Abstracts MA2023-01, no. 3 (2023): 802. http://dx.doi.org/10.1149/ma2023-013802mtgabs.

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Lithium-sulfur (Li-S) batteries feature a high theoretical capacity of 1675 mAh/g and hence is considered as a promising alternative to lithium-ion batteries. However, deployment of Li-S batteries has been hindered by the low practical energy and limited cycle life.1, 2 Reducing cathode porosity is essential to balancing the electrolyte distribution in Li-S cell, conserving more pore-filling electrolyte to extend cell cycle life.3-5 However, low-porosity electrodes built with nanosized sulfur/carbon (S/C) materials suffer from high tortuosity that significantly deteriorates electrode wetting a
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Lin, Sherry. "Reviewer Acknowledgements for Higher Education Studies, Vol. 8, No. 1." Higher Education Studies 8, no. 1 (2018): 72. http://dx.doi.org/10.5539/hes.v8n1p72.

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Higher Education Studies wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal are greatly appreciated.Higher Education Studies is recruiting reviewers for the journal. If you are interested in becoming a reviewer, we welcome you to join us. Please find the application form and details at http://recruitment.ccsenet.org and e-mail the completed application form to hes@ccsenet.org.Reviewers for Volume 8, Number 1Abdelaziz Mohammed, Albaha University, Saudi ArabiaA
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Krojer, Tobias, Romain Talon, Nicholas Pearce, et al. "TheXChemExplorergraphical workflow tool for routine or large-scale protein–ligand structure determination." Acta Crystallographica Section D Structural Biology 73, no. 3 (2017): 267–78. http://dx.doi.org/10.1107/s2059798316020234.

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XChemExplorer(XCE) is a data-management and workflow tool to support large-scale simultaneous analysis of protein–ligand complexes during structure-based ligand discovery (SBLD). The user interfaces of established crystallographic software packages such asCCP4 [Winnet al.(2011),Acta Cryst.D67, 235–242] orPHENIX[Adamset al.(2010),Acta Cryst.D66, 213–221] have entrenched the paradigm that a `project' is concerned with solving one structure. This does not hold for SBLD, where many almost identical structures need to be solved and analysed quickly in one batch of work. Functionality to track progr
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Gonçalves, Gabriela Sumie Yaguinuma, Tayna Natsumi Takakura, Anderson Catelan, Rosalinda Tanuri Zaninotto Venturim, Carolina dos Santos Santinoni, and Christine Men Martins. "Tratar ou extrair? Tratamento de lesão endoperiodontal, um relato de caso clínico." ARCHIVES OF HEALTH INVESTIGATION 9, no. 6 (2020): 535–40. http://dx.doi.org/10.21270/archi.v9i6.4814.

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Introdução: Lesões endoperiodontais são lesões originadas de produtos inflamatórios encontrados tanto em periodonto quanto em polpa. Tais lesões podem se originar devido a uma infecção pulpar ou periodontal. Visando o prognóstico favorável, é imprescindível o conhecimento da etiologia, realização do correto diagnóstico e elaboração do plano de tratamento que envolve o tratamento endodôntico precedido do tratamento periodontal. Objetivo: O propósito do presente trabalho foi de relatar um caso clínico de lesão endoperiodontal e o tratamento realizado. Relato de caso clínico: Paciente gênero femi
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Li, Defu, Faiz Ahmed, and Gao Liu. "Mixed Electronic-Ionic Conductive Polymer Binder for Silicon-Based Solid-State Battery." ECS Meeting Abstracts MA2024-01, no. 2 (2024): 313. http://dx.doi.org/10.1149/ma2024-012313mtgabs.

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Silicon has attracted extensive research attention in lithium-ion battery (LIB) field due to its high theoretical specific capacity (~3600 mAh/g) and cost-effectiveness. In recent years, silicon has emerged as a viable candidate for anode material for solid-state battery (SSB) technology. Similar to its application in LIBs, silicon utilizing in SSBs encounters challenges, such as significant volume variation (~300%) during cycling and poor cycling performance. In addition, the utilization of silicon in SSB faces another critical bottleneck in ionic conductivity due to the absence of liquid ele
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Sharannavar, Anupama, and Nizar Banu P K. "Performance Analysis of Clustering Algorithms for Dyslexia Detection." ECS Transactions 107, no. 1 (2022): 10021–34. http://dx.doi.org/10.1149/10701.10021ecst.

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Clustering algorithms plays a vital role in analyzing and evaluating vast number of high dimensional health care data ranging from medical data repositories, clinical data, electronic health records, body sensor networks, IoT devices, and so on. Dyslexia, a learning disorder, is a common problem that is found in children during the initial stages of formal education, which is detected as mild to severe. It can also be one of the reasons of failure in the school. According to the literature, this difficulty is commonly seen among special needs children in education. There are few studies focuse
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BARBOSA, DANILO PEREIRA, EDUARDO LEONEL BOTTEGA, DOMINGOS SÁRVIO MAGALHÃES VALENTE, NERILSON TERRA SANTOS, and WELLINGTON DONIZETE GUIMARÃES. "DELINEATION OF HOMOGENEOUS ZONES BASED ON GEOSTATISTICAL MODELS ROBUST TO OUTLIERS." Revista Caatinga 32, no. 2 (2019): 472–81. http://dx.doi.org/10.1590/1983-21252019v32n220rc.

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ABSTRACT Measures of the apparent electrical conductivity (ECa) of soil are used in many studies as indicators of spatial variability in physicochemical characteristics of production fields. Based on these measures, management zones (MZs) are delineated to improve agricultural management. However, these measures include outliers. The presence or incorrect identification and exclusion of outliers affect the variogram function and result in unreliable parameter estimates. Thus, the aim of this study was to model ECa data with outliers using methods based on robust approximation theory and model-
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Chan, Cerise Yuen Ki, Po Yee Wong, Helen Do Gai Xue, et al. "Abstract 511: Cell cycle inhibitors exhibit anti-tumor immunomodulatory roles through the HIF-1-DDX41 cytosolic DNA sensing pathway in HCC." Cancer Research 84, no. 6_Supplement (2024): 511. http://dx.doi.org/10.1158/1538-7445.am2024-511.

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Abstract Cell cycle inhibitors have a long history as anti-cancer therapeutics in clinical applications. Uncontrolled and infinite cell cycles are hallmarks of cancer, which enable them to proliferate rapidly and survive. To target these key features of cancer cells, cell cycle inhibitors are used to arrest their active cell cycle and induce cell death. In this study, beyond the known primary effect on cell cycle control, we identified that an expected and a secondary effect in immune modulation by the cell cycle inhibitors. Anti-mitotic agents including Paclitaxel (microtubule stabilizer), Pa
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CHENG, Xiong, Man Li, and Joonho Bae. "Novel DNA-Based Nanomaterials for High- Performance Lithium-Ion Batteries." ECS Meeting Abstracts MA2025-01, no. 37 (2025): 1771. https://doi.org/10.1149/ma2025-01371771mtgabs.

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In recent years, research on lithium-ion batteries and the application of organic biomolecules in electrochemical devices has attracted considerable attention from researchers.[1][2] Recently, we have studied the application of DNA in electrochemical energy storage devices.[3][4][5] In our latest work, we designed a novel PVDF@DNA solid polymer electrolyte and developed DNA-guided fabrication of LFP micro-roses. In the first study, DNA was used as an additive in polymer solid electrolytes, reducing crystallinity, enhancing ionic conductivity [6], and increasing free lithium ions through its Le
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., Nagmani, Dhrubajyoti Das, and Sreeraj Puravankara. "Boosting the Initial Coulombic Efficiency of Sustainable Hard Carbon Derived from Polyethylene Terephthalate with Cyclopentyl Methyl Ether As a Co-Solvent for Wide-Temperature Sodium-Ion Batteries." ECS Meeting Abstracts MA2023-02, no. 1 (2023): 123. http://dx.doi.org/10.1149/ma2023-021123mtgabs.

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Upcycling plastic waste into value-added products helps to generate cost-effective and sustainable resources towards a circular materials economy and safer ecosystem. The conversion of polyethylene terephthalate (PET) municipal waste via the carbonization process into hard carbon (HC) delivers a high-reversible capacity, low-cost, sustainable anode material for sodium-ion batteries (SIBs). However, the low initial Coulombic efficiency (ICE) is a significant challenge of the HC anode, which should be optimized by electrolyte and interfacial chemistry.1 In conventional carbonate esters-based ele
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Zhao, Dongni, Shaohua Zhang, Chun Lin, et al. "Covalent Heterojunctions Enhance Bi2S3/Reduced Graphene Oxide (rGO) Nanocomposite Performance as Aqueous Zinc Ion Battery Material." ECS Meeting Abstracts MA2023-01, no. 4 (2023): 837. http://dx.doi.org/10.1149/ma2023-014837mtgabs.

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The shortage of lithium resources, safety and recycling difficulty has focused attention on alternative energy storage devices in recent years. The aqueous zinc-ion battery (ZIB) stands out against such a background because of its earth abundance, safety, and environmental friendliness.1 However, the limited choice of cathode materials hinders the development of advanced high-energy-density aqueous ZIBs. At present, manganese oxide2 and vanadium oxide3 are the two most widely studied zinc-ion battery cathodes, but the migration of Zn2+ in these materials is limited by the strong electrostatic
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Jiao, C, Fuyong. "Current Status and Research Progress of Chinese Children’s Immunization During The COVID-19 the Pandemic Situation Fuyong Jiao1*, Fen Ma2 , Siqiong Li3 , Feng Yang4 , Wenxing Qiao5 andYang Xue5." Global Journal of Pediatrics (GJP) 01, no. 2 (2021): 1–6. http://dx.doi.org/10.54026/gjp/1005.

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Vaccination is the most economical and effective means to prevent control and even eliminate infectious diseases, and it is one of the most basic public health service items provided by the government to the masses. Every year, April 25th is the Publicity Day for Children’s Vaccination in China. Due to the new crown pneumonia, the city is closed to fight the epidemic, and the vaccination is suspended. My country’s rapid control of the new crown epidemic has started in an orderly manner with child vaccinations. In the 70 years since the founding of New China, my country’s public health, especia
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Cai, Chenguang, Xiang Li, Shin-Chen Hou, et al. "Abstract 5552: Novel set of OX40 targeted antibodies and VHHs include agonists and antagonists for future development." Cancer Research 82, no. 12_Supplement (2022): 5552. http://dx.doi.org/10.1158/1538-7445.am2022-5552.

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Abstract Immunotherapy is one of the most effective modern treatments for cancer. While immunotherapy operates through a broad class of mechanisms, modulating immune checkpoints have provided some of the most effective approaches, including inhibition of PD-1/PD-L1 pathway, CTLA-4, LAG-3, OX40, Tim-3, KIR and TIGIT to reverse tumor immune escape.OX40, also known as CD134 or TNFRSF4, is a membrane protein expressed in CD4+ and CD8+ T cells, neutrophils and NK cells. In the process of T cell activation, OX40 plays a synergistic stimulating function by binding with ligand OX40L. OX40 agonist immu
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Li, Jinyang, Yang Li, Nan Gao, et al. "Abstract 3510: A 2+1 format MUC16 targeting T cell engager induces MUC16-dependent T cell activity and superior anti-tumor efficacy." Cancer Research 85, no. 8_Supplement_1 (2025): 3510. https://doi.org/10.1158/1538-7445.am2025-3510.

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Abstract T cell engager (TCE) therapies targeting specific tumor associated antigens (TAAs) have shown clinical efficacy in multiple types of solid tumors. Indeed, TCE has been approved to treat melanoma and small cell lung cancer. Nevertheless, it remains necessary and challenging to improve the efficacy and safety profile of TCE to deliver benefits to more cancer patients. Recurrent and chemotherapy resistant ovarian cancer remains an urgent global unmet medical need. These is limited therapeutic options for this highly lethal and refractory disease. Recently, a MUC16 TCE demonstrated promis
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Hasan, Md Wahidul, Amir Abdul Razzaq, Ljalem Hadush Abrha, et al. "A Novel Strategy for the Development of High Energy Density, Long Cycle Life, and Safe Lithium-Sulfur Batteries." ECS Meeting Abstracts MA2025-01, no. 3 (2025): 442. https://doi.org/10.1149/ma2025-013442mtgabs.

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Lithium-sulfur (Li-S) batteries are regarded as one of the most promising next-generation energy storage technologies due to their high theoretical specific capacity, material abundance, and low production costs. Despite these advantages, the commercialization of Li-S batteries remains limited, primarily due to significant technical challenges,1-3 including the dissolution and shuttling of lithium polysulfides (PS), a major cause of fast capacity degradation over cycling in Li-S batteries. In our recent work,4 we introduced a novel sulfur cathode design comprising a thin film of nanolayer-poly
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Li, Xiao-Yun, Si-Yi Xie, Qiu-Yan Chen, Hai-Qiang Mai, and Lin-Quan Tang. "Abstract 4025: A phase II trial of neoadjuvant gemcitabine, cisplatin plus tislelizumab followed by concurrent chemoradiotherapy in locoregionally advanced nasopharyngeal carcinoma: Clinical efficacy, safety and the biomarker analysis." Cancer Research 84, no. 6_Supplement (2024): 4025. http://dx.doi.org/10.1158/1538-7445.am2024-4025.

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Abstract Immune checkpoint inhibitors (ICIs) have been widely used in recurrent or metastatic nasopharyngeal carcinoma (NPC), but the addition of ICIs to chemoradiotherapy in locoregionally advanced (LA) NPC requires further investigation. We conducted a phase II, single-arm trial to evaluate the efficacy and safety of neoadjuvant gemcitabine, cisplatin (GP) plus tislelizumab followed by concurrent chemoradiotherapy (CCRT) in LA-NPC. All participants received 3 cycles of GP chemotherapy plus tislelizumab (200 mg) followed by 3 cycles of cisplatin-based CCRT. The primary endpoint was the clinic
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48

Lin, Sherry. "Reviewer Acknowledgements for Higher Education Studies, Vol. 8, No. 2." Higher Education Studies 8, no. 2 (2018): 107. http://dx.doi.org/10.5539/hes.v8n2p107.

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Higher Education Studies wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal are greatly appreciated.Higher Education Studies is recruiting reviewers for the journal. If you are interested in becoming a reviewer, we welcome you to join us. Please find the application form and details at http://recruitment.ccsenet.org and e-mail the completed application form to hes@ccsenet.org.Reviewers for Volume 8, Number 2Abdelaziz Mohammed, Albaha University, Saudi ArabiaA
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Likhitrakarn, Natdanai, Sergei I. Golovatch, and Sopark Jantarit. "Two new species of the millipede genus Glyphiulus Gervais, 1847 (Diplopoda, Spirostreptida, Cambalopsidae) from caves in northern Thailand." ZooKeys 1056 (August 20, 2021): 173–89. https://doi.org/10.3897/zookeys.1056.71395.

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Two new species of the genus Glyphiulus Gervais, 1847 are described and illustrated. The first species, G. longus sp. nov., is the second species of the javanicus-group to be found in Thailand. It resembles G. guangnanensis Jiang, Guo, Chen & Xie, 2018, from southern China, but is distinguished by a smaller size and the carinotaxic formula of the collum, combined with ♂ legs 1 bearing very strongly reduced telopodites, the anterior gonopods showing a pair of very long and slender apicomesal processes, and the denser plumose and stout flagella of the posterior gonopods. The second species,
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Tang, Haoran, Cancan Jia, Feng Xie, et al. "Abstract P5-04-18: Clinical Validation of an Ultra-Sensitive ctDNA NGS Assay in HR-Positive, HER2-Negative Breast Cancer Patients." Clinical Cancer Research 31, no. 12_Supplement (2025): P5–04–18—P5–04–18. https://doi.org/10.1158/1557-3265.sabcs24-p5-04-18.

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Abstract Introduction: Breast cancer remains the most common cancer diagnosis among women worldwide, with the majority of cases being hormone receptor (HR)-positive and HER2-negative. Although endocrine therapies have significantly improved patient outcomes, the risk of disease progression persists, sometimes even during the initial treatment phases. Current diagnostic techniques lack the sensitivity needed for patients with low tumor fractions and circulating tumor DNA (ctDNA) shedding in the early stages of disease or during early disease progression. This study presents the clinical validat
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