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Journal articles on the topic 'Major Adverse Cardiac Event (MACE)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Berikashvili, L. B., A. N. Kuzovlev, M. Yа Yadgarov, K. K. Kadantseva, E. A. Ozhiganova, and V. V. Likhvantsev. "Nomogram M Prognostic Value for Major Adverse Cardiac and Cerebral Events after Elective Cardiac Surgery with Cardiopulmonary Bypass." Messenger of ANESTHESIOLOGY AND RESUSCITATION 19, no. 2 (2022): 6–13. http://dx.doi.org/10.21292/2078-5658-2022-19-2-6-13.

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The objective: to evaluate the prognostic value of Nomogram M for major adverse cardiac events (MACE) and major adverse cardiac and cerebral events (MACCE) after elective cardiac surgery with cardiopulmonary bypass.Subjects and Methods. This is a retrospective cohort study of the Nomogram M prognostic value for MACE and MACCE after elective cardiac surgery with cardiopulmonary bypass. 158 patients were enrolled in the study. The prognostic value was estimated using ROC-analysis.Results. The frequency of MACE and MACCE during hospitalization made 5.7% (9 of 158 patients) and 6.3% (10 of 158 pat

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Sayed Masri, Syarifah Noor Nazihah, Fadzwani Basri, Siti Nadzrah Yunus, and Saw Kian Cheah. "Cardiac Troponin as a Prognostic Indicator for Major Adverse Cardiac Events in Non-Cardiac Surgery: A Narrative Review." Diagnostics 15, no. 9 (2025): 1061. https://doi.org/10.3390/diagnostics15091061.

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A major adverse cardiac event (MACE) following non-cardiac surgery encompasses critical postoperative cardiovascular complications such as myocardial infarction or injury, cardiac arrest, or stroke that are associated with increased perioperative morbidity, mortality, and healthcare resource utilisation. Cardiac troponin (cTn), particularly high-sensitivity cardiac troponin (hs-cTn), has emerged as a key biomarker for prediction of MACE. Despite its recognised utility, there is no consensus on how cTn levels should be used for standardised postoperative surveillance. Interpretation of the cTn

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Garcia, Michael Cristian, Mason Anderson, Michelle Li, et al. "Major adverse cardiac events with haloperidol: A meta-analysis." PLOS One 20, no. 6 (2025): e0326804. https://doi.org/10.1371/journal.pone.0326804.

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Background Haloperidol is a commonly used antipsychotic drug and a frequent source of medication safety alerts because of its listing as a “known risk” QT interval-prolonging medication (QTPmed). We aimed to summarize the high-quality literature on the frequency and nature of proarrhythmic major adverse cardiac events (MACE) associated with haloperidol. Methods We searched Medline, Embase, International Pharmaceutical Abstracts, and Cochrane Central for randomized controlled trials (RCTs) involving patients 18 years or older comparing haloperidol to placebo. The FDA-adapted MACE composite incl

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Nwaedozie, Somto, Chuyang Zhong, Peter Umukoro, et al. "Adverse Cardiac Events Risks of Non-Obstructive Coronary Artery Disease by Cardiac CT Angiography at One-Year Follow-Up: Results of the Coronary Risk Determination in Intermediate Stratum Coronary CT Angiography (CORDISC) Study." International Journal of Innovative Research in Medical Science 7, no. 01 (2022): 1–8. http://dx.doi.org/10.23958/ijirms/vol07-i01/1322.

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We conducted a retrospective cohort study of the adverse events at one year post-cardiac computed tomography (cardiac CT) using data gathered from the Marshfield Clinic Health System (MCHS) Cardiac CT registry to compare non-fatal myocardial infarction (MI), revascularization, all-cause mortality, and composite major adverse cardiac events (MACE) one year following cardiac CT in patients with non-obstructive coronary artery disease (CAD) and normal coronary arteries. From 2009 to 2017, the records of 2,649 patients who underwent cardiac CT were reviewed. CAD detected by cardiac CT was defined

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Davies, Elin Mitford, Benjamin J. R. Buckley, Philip Austin, Gregory Y. H. Lip, Anirudh Rao, and Garry McDowell. "Cardiac Biomarkers Predict Major Adverse Cardiac Events (MACE) in Incident Haemodialysis Patients: Results from a Global Federated Database." Biomedicines 13, no. 2 (2025): 367. https://doi.org/10.3390/biomedicines13020367.

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Background: Despite its many advantages, haemodialysis (HD) has been shown to be associated with significant cardiovascular events, especially in patients commencing HD. Currently, there is no specific method to risk-stratify incident HD patients. Blood-based biomarkers provide insight into myocardial injury and stress. We aimed to evaluate the association of increased circulating biomarker concentration in incident HD with incident major adverse cardiac events (MACE). Methods: This was a retrospective cohort study of incident haemodialysis cases within 3 months of treatment initiation (≥18 ye

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Dendale, Paul, Jan Berger, Dominique Hansen, Johan Vaes, Edouard Benit, and Maria Weymans. "Cardiac Rehabilitation Reduces the Rate of Major Adverse Cardiac Events after Percutaneous Coronary Intervention." European Journal of Cardiovascular Nursing 4, no. 2 (2005): 113–16. http://dx.doi.org/10.1016/j.ejcnurse.2004.11.003.

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Background: Despite multiple publications on effects of rehabilitation in cardiac patients, rehabilitation is not fully known to be of value in post-percutaneous coronary intervention (PCI) patients. Aims: To investigate the influence of cardiac rehabilitation on the incidence of major adverse cardiac events (MACEs) in post-PCI patients. Methods: Retrospectively and nonrandomized 140 post-PCI patients (107 males, mean age 62 (7) years) participated in a 3-month rehabilitation program, starting 2 weeks post-PCI, while 83 post-PCI patients (54 males, mean age 68 (8) years) did not and were all f

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Kurian, Amrita, Poornima H, and Abdul Salam. "Association of Total Leucocyte Count and Neutrophil to Lymphocyte Ratio with Short Term Major Adverse Cardiac Events after Acute ST Elevation Myocardial Infarction in a Tertiary Care Centre in South India." Galore International Journal of Health Sciences and Research 8, no. 2 (2023): 27–34. http://dx.doi.org/10.52403/gijhsr.20230206.

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Ischemic Heart Disease is a global health issue with developing countries bearing the brunt of the burden. The development of adverse cardiac events after an acute coronary event further aggravates the morbidity and mortality. In a developing country like India, employing inexpensive markers such as Total Leucocyte Count (TLC) and Neutrophil to Lymphocyte Ratio (NLR) can greatly aid prognostication in acute myocardial infarction. The study aimed at estimating the association of TLC and NLR with short term Major Adverse Cardiac Events (MACE) after acute STEMI. We also studied the association of

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Chetan, R. Patela* Mandev B. Patelb. "A study to compare Major Adverse Cardiac Event in patient undergoing PCI with Drug Eluting Stents Vs Bare Metal Stents." Journal of Pharma Research 1, no. 1 (2012): 12–15. https://doi.org/10.5281/zenodo.1098639.

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<strong><em>ABSTRACT</em></strong> <em>This study compared Major Adverse Cardiac Event in patient with Acute Coronary Syndromes undergoing PCI with Drug Eluting Stents Vs Bare Metal Stents. A retrospective, observational study was carried out in an inpatient setting of the private tertiary care hospital. Patients with >18 years, diagnosed for Acute Coronary Syndromes (ACS), required intervention in coronary artery with implantation of Drug Eluting Stents (DES) or Bare Metal Stents (BMS) were recruited in the study. The data had been collected from file or database of the hospital. All subje

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Dabić, Petar, Jovan Petrović, Bojan Vučurević, et al. "Major adverse cardiac events in vascular surgery patients with peripheral arterial disease." Medicinska istrazivanja 57, no. 1 (2024): 9–13. http://dx.doi.org/10.5937/medi57-47260.

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Introduction: Major adverse cardiac events (MACE) are the primary cause of morbidity and mortality in patients undergoing vascular surgical procedures. This is why it is essential to understand the relationship between coronary artery disease and peripheral arterial disease. In this paper, we aimed to determine predictors and risk factors related to the occurrence of MACE in patients undergoing vascular surgery for peripheral arterial disease. Material and Methods: This is a retrospective study of 310 in-hospital patients treated at a high-volume vascular centre. The outcome was classified thr

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Habib, Mohammed. "Evaluation of Major Adverse Cardiac Events After Cardiac Surgery in Gaza." Japan Journal of Clinical & Medical Research 3, no. 3 (2023): 1–3. http://dx.doi.org/10.47363/jjcmr/2023(3)156.

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Background: The present study assessed the major adverse cardiac events (MACE) (hospital mortality rate, major stroke and reintervention) after cardiac surgery du to coronary artery bypass grafting or valve surgery or both in the Ministry of health hospitals (MOH) in Gaza Strip at 2022 by either Local or Expert cardiac surgery team.

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Kasim, Manoefris, Geoffrey M. Currie, Markus Tjahjono, Bambang B. Siswanto, Ganesja M. Harimurti, and Hosen Kiat. "Myocardial Perfusion SPECT Utility in Predicting Cardiovascular Events Among Indonesian Diabetic Patients." Open Cardiovascular Medicine Journal 7, no. 1 (2013): 82–89. http://dx.doi.org/10.2174/1874192401307010082.

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Background: Indonesia has the fourth largest number of diabetes patients after India, China and the USA. Coronary artery disease (CAD) is the most common cause of death in diabetic patients. Early detection and risk stratification is important for optimal management. Abnormal myocardial perfusion imaging (MPI) is an early manifestation in the ischemic cascade. Previous studies have demonstrated the use of MPI to accurately diagnose obstructive CAD and predict adverse cardiac events. This study evaluated whether MPI predicts adverse cardiac event in an Indonesian diabetic population. Method: Th

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Nabi, Hafsah, Rasmus Rørth, Daniel H. Tajchman, et al. "Antithrombotic treatment and major adverse cardiac events after bleeding in patients with myocardial infarction: a retrospective analysis of nationwide registry data." European Heart Journal - Cardiovascular Pharmacotherapy 6, no. 1 (2019): 14–21. http://dx.doi.org/10.1093/ehjcvp/pvz025.

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Abstract Aims The aim of this study was to describe the use of antithrombotic therapy following a bleeding event among patients with myocardial infarction (MI), and the associated risk of major adverse cardiac events (MACE). Methods and results Using Danish nationwide registries, patients hospitalized with a bleeding event within 1 year after MI were identified. Antithrombotic treatment with aspirin, clopidogrel, and/or vitamin K antagonists (VKA) was determined at the bleeding and at Day 90 and 180 post-bleed. Based on guidelines, patients were stratified into four groups: expected, reduced,

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Mohammed, Muaath Ahmed Hasan, Zulkefli Sanip, Zurkurnai Yusof, and W. Yus Haniff W. Isa. "Risk Factors for Major Adverse Cardiac Events Outcomes in Post Percutaneous Coronary Intervention during Index Admission." JULY 2023 19, no. 4 (2023): 130–38. http://dx.doi.org/10.47836/mjmhs.19.4.20.

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Introduction: Patients with ST-segment elevation myocardial infarction (STEMI) often undergo percutaneous coronary intervention (PCI) procedures during their index hospitalisation. However, some factors may increase the risk of major adverse cardiac event (MACE) outcomes after delaying PCI. We aimed to determine the risk factors for MACE outcomes in acute STEMI patients who had PCI during their index admission. Methods: In this retrospective single-center study, the medical records of STEMI patients who had PCI during their index hospitalisation in our facility were retrieved. At 30 days and s

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Serafimov, Aleksandar, Darko Donevski, Marija Karakolevska Ilova, et al. "Incremental Value of Cardiac Biomarkers in Mid-term Prognosis of Patients with Acute Coronary Syndrome." Open Access Macedonian Journal of Medical Sciences 10, B (2022): 294–302. http://dx.doi.org/10.3889/oamjms.2022.7978.

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Background: Given the number of prognostic studies, both short- and long-termed, in patients with myocardial infarction (MI), the data on predicting major adverse cardiac events (MACE) following discharge still remains limited. Aim: to identify early predictors of MACE in MI patients, that underwent Primary Percutaneous Coronary Intervention (pPCI), with special emphasis on multiple cardiac biomarkers. Materials and methods: we analysed clinical, LV functional, angiographic variables, as well cardiac troponin, a marker of myocardial necrosis, natriuretic peptide (NT-proBNP), a marker of myocar

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Hartopo, Anggoro Budi, Dyah Samti Mayasari, Ira Puspitawati, and Hasanah Mumpuni. "Circulating Platelet-Derived Microparticles Associated with Postdischarge Major Adverse Cardiac Events in ST-Elevation Acute Myocardial Infarction." Cardiology Research and Practice 2020 (July 6, 2020): 1–10. http://dx.doi.org/10.1155/2020/6721584.

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Introduction. Platelet-derived microparticles (PDMPs) measurement adds prognostic implication for ST-elevation acute myocardial infarction (STEMI). The long-term implication of PDMPs in STEMI needs to be corroborated. Methods. The research design was a cohort study. Subjects were STEMI patients and were enrolled consecutively. The PDMPs were defined as microparticles bearing CD41(+) and CD62P(+) markers detected with flow cytometry. The PDMPs were measured on hospital admission and 30 days after discharge. The outcomes were major adverse cardiac events (MACE), i.e., a composite of cardiac deat

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Al-Zakwani, Ibrahim, Fahad AlKindi, Wael Almahmeed, and Mohammad Zubaid. "Impact of Revascularization on Major Adverse Cardiovascular Events in Patients Without ST-Elevation Myocardial Infarction in the Arabian Gulf." Journal of Cardiovascular Development and Disease 12, no. 4 (2025): 117. https://doi.org/10.3390/jcdd12040117.

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Objectives: The study evaluated the impact of revascularization procedures, including percutaneous coronary intervention (PCI) and coronary artery bypass graft (CABG), during the index hospitalization on major adverse cardiovascular events (MACE) in patients with non-ST-elevation myocardial infarction (NSTEMI) in the Arabian Gulf. Methods: Data were analyzed from 1820 consecutive patients diagnosed with NSTEMI, admitted to 29 hospitals in four Arabian Gulf countries from January 2012 to January 2013, and who were discharged alive. Results: Of the patients, 29.1% (n = 529) underwent either PCI

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Nayanar, V. Krishna Narayanan, U. Abinaya Prakashbabu, MS Saravana Babu, Subin Sukesan, P. Unnikrishnan Koniparambil, and Prasanta K. Dash. "Evaluation of Perioperative Major Adverse Cardiac Events in Patients with Coronary Artery Disease Undergoing Carotid Endarterectomy." Annals of Cardiac Anaesthesia 28, no. 3 (2025): 280–86. https://doi.org/10.4103/aca.aca_210_24.

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Abstract Background: Major adverse cardiac events (MACE) are the leading cause of morbidity and mortality during carotid endarterectomy (CEA). The primary outcome of the study was to assess the incidence of perioperative MACE and non-MACE in patients with coronary artery disease (CAD) undergoing CEA. The secondary objectives were to analyze the incidence of MACE and non-MACE based on various perioperative risk factors. Methods: This retrospective study included patients with CAD who underwent CEA for carotid artery disease from July 2013 to June 2023. We analyzed the incidence of perioperative

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Al-Zakwani, Ibrahim, Jawad Al-Lawati, Alawi A. Alsheikh-Ali, et al. "Impact of Dual versus Single Antiplatelet Therapy on Major Cardiovascular Outcomes in Patients with Acute Coronary Syndrome in the Arabian Gulf." Medical Principles and Practice 29, no. 2 (2019): 181–87. http://dx.doi.org/10.1159/000503438.

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Objective: To evaluate the association of dual versus single antiplatelet therapy with major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) in the Arabian Gulf. Subjects and Methods: Data were analyzed from 3,559 patients with a diagnosis of ACS admitted to 29 hospitals in 4 Arabian Gulf countries (Bahrain, Kuwait, Oman, and United Arab Emirates) from January 2012 to January 2013. Dual antiplatelet therapy (DAPT), consisting of aspirin and clopidogrel, was compared to aspirin alone. MACE included 12-months cumulative stroke/transient ischemic attack (TIA),

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Kristin, Erna, Lucia Kris Dinarti, Alfi Yasmina, Woro Rukmi Pratiwi, Rizaldy Taslim Pinzon, and Sudi Indra Jaya. "Persistence with Antiplatelet and Risk of Major Adverse Cardiac and Cerebrovascular Events in Acute Coronary Syndrome Patients after Percutaneous Coronary Intervention in Indonesia: A Retrospective Cohort Study." Open Access Macedonian Journal of Medical Sciences 10, B (2022): 900–904. http://dx.doi.org/10.3889/oamjms.2022.9180.

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BACKGROUND: Acute coronary syndrome (ACS) is a life-threatening condition that carries high risk of recurrent cardiovascular events and death. Persistence with treatment is known to reduce morbidity and mortality in patients with ACS. AIM: This study focuses on ACS patients undergoing their first percutaneous coronary intervention (PCI) to investigate the association between persistence with antiplatelet therapy and clinical outcomes. MATERIALS AND METHODS: A retrospective cohort study with 2 years of follow-up was conducted with 367 patients recruited. Patients were deemed as having persisten

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Putra, Hery D., Cut Aryfa Andra, and Zainal Safri. "Functional Capacity Change after Phase II Cardiac Rehabilitation as a Predictor of Major Adverse Cardiac Event in Left Ventricular Dysfunction Patients Underwent Coronary Artery Bypass Grafting." International Journal of Research and Review 8, no. 10 (2021): 326–32. http://dx.doi.org/10.52403/ijrr.20211044.

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Background: Phase II cardiac rehabilitation is essential for management post coronary artery bypass graft (CABG), especially in patients with left ventricular systolic dysfunction. Change in functional capacity after phase II cardiac rehabilitation (∆METs) is an indicator of cardiopulmonary and hemodynamic improvement after CABG. This study assessed the correlation of ∆METs as a predictor of major adverse cardiac event (MACE) 3 months after CABG in patients with left ventricular systolic dysfunction. Methods: A cohort study was conducted on patients with left ventricular systolic dysfunction w

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Bestara, Adi, Trisulo Wasyanto, and Niniek Purwaningtyas. "The Roles of Pentraxin-3 to Predict In-Hospital and Three Months Major Adverse Cardiac Event in Acute Myocardial Infarction." ACI (Acta Cardiologia Indonesiana) 6, no. 2 (2020): 111–20. http://dx.doi.org/10.22146/jaci.v6i2.627.

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Background: Pentraxin-3 (PTX3) was a useful marker for localized vascular inflammation and damage in the cardiovascular system. Recent studies have shown that plasma PTX3 is elevated in patients with myocardial infarction; however, its prognostic value still remains unclear. Aims: This study aimed to investigate the relationship between PTX3 and in-hospital and three months of a major adverse cardiac event (MACE) in acute ST-elevation and non-ST-elevation myocardial infarction patients. Methods: This cohort study conducted from September 1st, 2018 to October 31st, 2019 in Dr. Moewa

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Rydman, Riikka, Yumi Shiina, Gerhard-Paul Diller, et al. "Major adverse events and atrial tachycardia in Ebstein’s anomaly predicted by cardiovascular magnetic resonance." Heart 104, no. 1 (2017): 37–44. http://dx.doi.org/10.1136/heartjnl-2017-311274.

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ObjectivesPatients with Ebstein’s anomaly of the tricuspid valve (EA) are at risk of tachyarrhythmia, congestive heart failure and sudden cardiac death. We sought to determine the value of cardiovascular magnetic resonance (CMR) for predicting these outcomes.MethodsSeventy-nine consecutive adult patients (aged 37±15 years) with unrepaired EA underwent CMR and were followed prospectively for a median 3.4 (range 0.4–10.9) years for clinical outcomes, namely major adverse cardiovascular events (MACEs: sustained ventricular tachycardia/heart failure hospital admission/cardiac transplantation/death

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Kunihara, Takashi, Olaf Wendler, Kerstin Heinrich, Ryota Nomura, and Hans-Joachim Schäfers. "Coronary Artery Bypass Grafting in Diabetic Patients: Complete Arterial versus Internal Thoracic Artery and Sequential Vein Grafts—A Propensity-Score Matched Analysis." Thoracic and Cardiovascular Surgeon 67, no. 06 (2018): 428–36. http://dx.doi.org/10.1055/s-0038-1660518.

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Abstract Background The optimal choice of conduit and configuration for coronary artery bypass grafting (CABG) in diabetic patients remains somewhat controversial, even though arterial grafts have been proposed as superior. We attempted to clarify the role of complete arterial revascularization using the left internal thoracic artery (LITA) and the radial artery (RA) alone in “T-Graft” configuration on long-term outcome. Methods and Results From 1994 to 2001, 104 diabetic patients with triple vessel disease underwent CABG using LITA/RA “T-Grafts” (Group-A). Using propensity-score matching, 104

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Nasution, Sally Aman, Hendra Perkasa, Eka Ginanjar, and Ikhwan Rinaldi. "In-Hospital Major Adverse Cardiac Events Factor Predictors on ST-Elevation Myocardial Infarction after Primary Percutaneous Coronary Intervention at dr. Cipto Mangunkusumo General Hospital." eJournal Kedokteran Indonesia 10, no. 2 (2022): 107–13. http://dx.doi.org/10.23886/ejki.10.193.107-13.

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Major Adverse Cardiac Events (MACE) are the main causes to increase mortality in ST-Elevation Myocardial Infarction (STEMI) patients who undergo Primary Percutaneous Coronary Intervention (PPCI). In-hospital MACE inducing factor predictors identification is expected to enhance STEMI patients’ care and outcome. This study aims to identify in-hospital MACE factor predictors in STEMI patients with PPCI treatment at RSCM. Retrospective cohort study by tracing medical records on patients with PPCI treatment at RSCM from January 2015 - March 2020. The chi-squared bivariate analysis concluded between

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Gao, Xiuxin, Yixiang Liu, Yanan Tian, et al. "Prognostic value of peripheral blood inflammatory cell subsets in patients with acute coronary syndrome undergoing percutaneous coronary intervention." Journal of International Medical Research 49, no. 4 (2021): 030006052110100. http://dx.doi.org/10.1177/03000605211010059.

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Objective This study aimed to investigate the predictive value of inflammatory cells in peripheral blood on the prognosis of patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Methods Patients (n=1558) were consecutively enrolled and the median follow-up was 1142 days. Patients were divided into the major adverse cardiac events (MACE) 1 group (n=63) (all-cause mortality [n=58] and rehospitalization for severe heart failure [n=5], no MACE1 group (n=1495), MACE2 group (n=38) (cardiac mortality [n=33] and rehospitalization for severe heart failure [n=

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O'Rielly, C., J. Andruchow, and A. McRae. "LO17: Major adverse cardiac events in patients ruled-out by a validated high-sensitivity troponin algorithm for acute myocardial infarction." CJEM 22, S1 (2020): S13. http://dx.doi.org/10.1017/cem.2020.73.

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Introduction: Chest pain and symptoms of acute coronary syndrome are a leading cause of emergency department (ED) visits in Canada. Validated 2-hour high-sensitivity troponin algorithms can rapidly and accurately rule-in or rule-out myocardial infarction (MI) in most patients. The objective of this study was to quantify the incidence and timing of major adverse cardiac events (MACE: MI, death, or urgent revascularization) in the 30-days following the index ED encounter among patients who had MI ruled out using a 2-hour high-sensitivity troponin T (hs-cTnT) algorithm. We also sought to identify

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Ziaee, Mojtaba, Sina Mashayekhi, Samad Ghaffari, Javad Mahmoudi, Parvin Sarbakhsh, and Alireza Garjani. "Predictive Value of Endocan Based on TIMI Risk Score on Major Adverse Cardiovascular Events After Acute Coronary Syndrome." Angiology 70, no. 10 (2018): 952–59. http://dx.doi.org/10.1177/0003319718815241.

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We assessed the prognostic value of serum levels of endocan in patients with the acute coronary syndrome (ACS) through its correlation with the Thrombolysis in Myocardial Infarction (TIMI) risk score and compared the possible association with clinical outcomes. In this prospective cross-sectional study, we enrolled 320 patients with documented ST-segment elevation myocardial infarction (STEMI), non-STEMI (NSTEMI), or unstable angina (UA) who underwent diagnostic coronary angiography. Endocan was measured soon after admission in the emergency department. In-hospital death, heart failure, and re

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Villegas-Quintero, Víctor Eder, Rodolfo Rivas-Ruíz, Alexis Alejandro García-Rivero, Pedro Rivera-Lara, and Nelly Berenice González-Tovar. "[Efficacy and safety of atorvastatin in major cardiovascular events: Meta-analysis]." Revista Médica del Instituto Mexicano del Seguro Social 61, Suppl 3 (2023): S407—S415. https://doi.org/10.5281/zenodo.8319748.

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<strong>Abstract </strong><strong>Introduction:</strong> Atorvastatin has been used in the management of dyslipidemia and little is known about the efficacy and safety of high-dose atorvastatin administration for secondary prevention of Major Cardiovascular Events (MACE).Objective: To evaluate the impact of high-dose atorvastatin on secondary prevention of MACE and adverse events.<strong>Material and methods:</strong> A systematic review and meta-analysis of Pubmed, Embase, Bireme and Cochrane Library Plus databases was performed, with a time scope from 1990 to July 2022. Six randomized c

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Franey, Ericha G., Donna Kritz-Silverstein, Erin L. Richard, et al. "Association of Race and Major Adverse Cardiac Events (MACE): The Atherosclerosis Risk in Communities (ARIC) Cohort." Journal of Aging Research 2020 (March 21, 2020): 1–7. http://dx.doi.org/10.1155/2020/7417242.

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Background and Aims. To evaluate the association of self-reported race with major adverse cardiac events (MACE) and modification of this association by paraoxonase gene (PON1, PON2, and PON3) single nucleotide polymorphisms (SNPs). Methods. Included in this longitudinal study were 12,770 black or white participants from the Atherosclerosis Risk in Communities (ARIC) cohort who completed a baseline visit (1987–1989) with PON genotyping. Demographic, behavioral, and health information was obtained at baseline. MACE was defined as first occurrence of myocardial infarction, stroke, or CHD-related

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Azali, Leylah, Lindsay Hazelden, Tracy Wiczer, et al. "Evaluation of the Incidence and Risk Factors Associated with Major Cardiovascular Events in Patients Receiving Acalabrutinib Therapy." Blood 136, Supplement 1 (2020): 29–30. http://dx.doi.org/10.1182/blood-2020-137800.

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Background Acalabrutinib is a highly selective second-generation Bruton's tyrosine kinase (BTK) inhibitor approved for the treatment of chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Ibrutinib, the first-generation nonselective BTK inhibitor, has been associated with cardiovascular (CV) complications including atrial fibrillation and ventricular arrhythmias, potentially related to off-target effects. In prior studies, the incidence of major adverse cardiovascular effects (MACE) with ibrutinib was 16.5-38%. With acalabrutinib being more selective, we postulate that less of these o

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LIU, Zi-jia, Chun-hua YU, Li XU, Wei HAN, Jing-mei JIANG, and Yu-guang HUANG. "Risk factors for perioperative major cardiac events in Chinese elderly patients with coronary heart disease undergoing noncardiac surgery." Chinese Medical Journal 126, no. 18 (2013): 3464–69. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20122793.

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Background Few studies have investigated perioperative major adverse cardiac events (MACEs) in elderly Chinese patients with coronary heart disease (CHD) undergoing noncardiac surgery. This study examined the incidence and risk factors for perioperative MACE in elderly patients who underwent noncardiac surgery, and established a risk stratification system. Methods This retrospective observational clinical study included 482 patients aged ≥60 years with CHD who underwent elective major noncardiac surgery at the Peking Union Medical College Hospital. The primary outcome was MACE within 30 days a

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Lacanin, Mary Rose Anne E., Edwin S. Tucay, Ana Beatriz R. Medrano, and Rylan Jasper B. Ubaldo. "Two-Dimensional Speckle Tracking Echocardiography as Predictor of Major Adverse Cardiac Events in Patients With Non–ST-Elevation Myocardial Infarction and Unstable Angina." Philippine Journal of Cardiology 50, no. 1 (2022): 34–42. http://dx.doi.org/10.69944/pjc.986233d38d.

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INTRODUCTION: This study was conducted to determine the utility of two-dimensional speckle tracking echocardiography (2D STE) in predicting major adverse cardiac events (MACEs) in patients with non–ST-elevation acute coronary syndrome (NSTE-ACS). METHODOLOGY: This is a prospective cohort study that included 91 patients diagnosed to have NSTE-ACS. In-hospital and 6-month MACEs were evaluated in relation to their baseline echocardiographic parameters, 2D speckle strain, and strain rate analyses. RESULTS: Among the conventional echocardiographic parameters, only left ventricular end systolic diam

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Choi, Dong-Hyun, Yuhei Kobayashi, Takeshi Nishi, et al. "Combination of Mean Platelet Volume and Neutrophil to Lymphocyte Ratio Predicts Long-Term Major Adverse Cardiovascular Events After Percutaneous Coronary Intervention." Angiology 70, no. 4 (2018): 345–51. http://dx.doi.org/10.1177/0003319718768658.

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We hypothesized that the combination of a high neutrophil to lymphocyte ratio (NLR) and mean platelet volume (MPV) would be a stronger predictor of future cardiovascular events after percutaneous coronary intervention (PCI). Both NLR and MPV were measured in 364 consecutive patients undergoing PCI. The primary end point was the incidence of major adverse cardiovascular events (MACEs), including cardiac death, nonfatal myocardial infarction, and stent thrombosis. The median values of NLR and MPV were 2.8 and 8.2 fL, respectively. There were 26 MACEs during a median follow-up duration of 29.3 mo

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Choe, Jeong Cheon, Kwang Soo Cha, Hye Yoon Jang, et al. "Outcomes of Acute Myocardial Infarction Patients Implanted With Biodegradable Polymer Biolimus-Eluting Stents Versus New-Generation Durable Polymer Drug-Eluting Stents: A Retrospective Analysis." Angiology 68, no. 8 (2016): 698–706. http://dx.doi.org/10.1177/0003319716679339.

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We compared outcomes between biodegradable polymer biolimus-eluting stent (BP-BES) and new-generation durable polymer drug-eluting stent (DP-DES) implantations in patients with acute myocardial infarction (MI). Among 13472 patients with acute MI in a nationwide registry, 557 (64.8%) were in the BP-BES and 303 (35.2%) in the new-generation DP-DES group following coronary reperfusion. The occurrence of major adverse cardiac events (MACE; death, MI, revascularization) and stent thrombosis was compared. Major adverse cardiac events occurred in 53 (6.2%) patients and showed similar rates between th

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Omari, Ramsey, Charles Curtis, Nichole Burket, Michael Weisman, Xiaofeng Chen, and Tim Lautenschlaeger. "Major Adverse Cardiac Events After Radiation Therapy in Lung Cancer." Proceedings of IMPRS 4, no. 1 (2021). http://dx.doi.org/10.18060/25761.

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Motivation:  Receiving radiation to the heart has been recognized as a risk factor for the development of major adverse cardiovascular events (MACEs) for many years. However, recent data suggests that radiation dosing to substructures of the heart serve as a better surrogate for evaluating the risk of developing a MACE than whole heart radiation dose. Recent papers suggest that dosing to the left anterior descending artery (LAD) can be used as a robust marker for cardiotoxicity risk; however, this association lacks corroborative data and is currently not incorporated into clinically rout

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Imperiali, Claudia E., Juan C. Lopez-Delgado, Macarena Dastis-Arias, and Lourdes Sanchez-Navarro. "Biomaker evaluation for major adverse cardiovascular event development in patients undergoing cardiac Surgery." Advances in Laboratory Medicine / Avances en Medicina de Laboratorio, July 25, 2020. http://dx.doi.org/10.1515/almed-2020-0031.

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AbstractObjectivesThe postoperative period of cardiac surgery (CS) is associated with the development of major adverse cardiovascular events (MACEs). However, the evaluation of MACE after CS by means of biomarkers is poorly developed. We aimed to evaluate postoperative biomarkers that could be associated with MACE.MethodsTwo Hundred and ten patients who underwent CS were enrolled during the study period. The diagnosis of MACE was defined as the presence of at least one of the following complications: acute myocardial infarction, heart failure, stroke presented during intensive care unit (ICU)

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Kaur, Ravinder Jeet, Byron H. Smith, Shafaq R. Rizvi, et al. "SUN-624 Low Risk of Major Adverse Cardiovascular Events After Pancreas Transplantation Alone." Journal of the Endocrine Society 4, Supplement_1 (2020). http://dx.doi.org/10.1210/jendso/bvaa046.1791.

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Abstract INTRODUCTION: Type 1 Diabetes (T1D) patients have an increased risk for major adverse cardiovascular events (MACE). Pancreas Transplantation Alone (PTA) in patients with T1D achieves near normal glucose control for a prolonged period but limited data are available to date regarding MACE during a 10 year follow up period after the procedure. OBJECTIVE: We studied incidence of MACE after PTA in T1D patients over a 10 year follow-up period. METHODS: Retrospectively, we studied 113 T1D recipients of PTA at Mayo Clinic, Rochester with the procedure performed between January 1998 and August

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Fohle, Emmanuel, Ninad Nadkarni, Filip Oleszak, et al. "Abstract 13144: High Polygenic Risk Score is a Predictor for Major Adverse Cardiac Event." Circulation 148, Suppl_1 (2023). http://dx.doi.org/10.1161/circ.148.suppl_1.13144.

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Background: The polygenic risk score for coronary artery disease (CAD PRS) is an emerging CAD risk assessment tool. It is unclear if it improves predictive value for major adverse cardiovascular events (MACE). This study aims to investigate the value of PRS as predictor for MACE. Methods: Patients who had coronary calcium score (CAC) within the Sanford Heart Screening Program were enrolled in the study from 2011-2021. They were genotyped using Illumina Global Screening Array version 1. PRS was calculated using a literature derived list of 180 single nucleotide polymorphisms. Patients were clas

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Lee, E., B. Tan, Y. H. Chin, et al. "Insights into the reporting of major adverse cardiovascular events in coronary artery disease trials." European Heart Journal 45, Supplement_1 (2024). http://dx.doi.org/10.1093/eurheartj/ehae666.1556.

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Abstract Background and Purpose Major adverse cardiovascular event (MACE) is one of the most used composite outcomes in coronary artery disease (CAD) trials, though its lack of a standardised definition has led to ambiguity and challenges in its interpretation. This study aims to elucidate the definition of MACE and guide future interpretation of MACE in the context of CAD trials. Methods A systematic review was conducted by searching Medline, Embase and Cochrane for double-blind pharmacological randomized-controlled trials among participants with CAD from 2012 to 2022 that reported MACE outco

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Lee, Hyo Jin, Kyunghwan Jeong, Hyeon Seok Hwang, et al. "#4378 GLOMERULAR HYPERFILTRATION AS RISK FACTOR FOR MAJOR ADVERSE CARDIOVASCULAR EVENTS AFTER ACUTE MYOCARDIAL INFARCTION." Nephrology Dialysis Transplantation 38, Supplement_1 (2023). http://dx.doi.org/10.1093/ndt/gfad063c_4378.

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Abstract Background and Aims A reduced glomerular filtration rate (GFR) is a definite risk factor for major adverse cardiovascular event (MACE) in acute myocardial infarction (AMI) patients. While glomerular hyperfiltration (GHF) is associated with early phases of kidney disease, it is unclear whether GHF is associated with higher risk of MACE. Method 9,561 AMI patients with estimated GFR ≥ 60 mL/min/1.73 m2 were enrolled from prospective population-based national cohort. GHF was defined as GFR &gt; 90th percentile after adjustment for age, sex, lean body mass and history of diabetes and h

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Caliskan, Etem, Martin Misfeld, Sigrid Sandner, et al. "Clinical event rate in patients with and without left main disease undergoing isolated CABG: results from the European DuraGraft registry." European Journal of Cardio-Thoracic Surgery, August 5, 2022. http://dx.doi.org/10.1093/ejcts/ezac403.

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Abstract Objectives Left main coronary artery disease (LMCAD) is considered an independent risk factor for clinical events after coronary artery bypass grafting (CABG). We have conducted a subgroup analysis of the multicentre European DuraGraft registry to investigate clinical event-rates at 1-year in patients with and without LMCAD undergoing isolated CABG in contemporary practice. Methods Patients undergoing isolated CABG were selected. The primary end-point was the incidence of a major adverse cardiac event (MACE) defined as the composite of death, myocardial infarction (MI) or repeat revas

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Lopes, V., J. P. Baptista, N. Moreira, and L. Goncalves. "Major adverse cardiac events in critically ill COVID-19 patients." European Heart Journal 43, Supplement_2 (2022). http://dx.doi.org/10.1093/eurheartj/ehac544.1479.

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Abstract Background Critically ill patients hospitalized with COVID-19 are at high risk of developing major adverse cardiac events (MACE). Purpose This study aimed to identify independent predictors of MACE after intensive care unit (ICU) admission which could be used to identify high-risk patients who may benefit from preventive strategies. Methods We retrospectively analyzed patients consecutively admitted to an ICU with COVID-19 and followed them for a median period of 7 months. Patients admitted due to trauma or emergent surgery were excluded. Logistic regression analysis was performed to

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Aizawa, Takatoku, Yasunori Inoue, Satoshi Ito, et al. "Time-dependent changes in P2Y12 reaction unit values for predicting the different types of cardiovascular events in patients with ischemic heart disease." Heart and Vessels, June 15, 2023. http://dx.doi.org/10.1007/s00380-023-02279-0.

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AbstractSeveral studies have investigated the association between P2Y12 reaction unit (PRU) value and major adverse cardiovascular events (MACEs) in patients with ischemic heart disease, but there is no well-established consensus on the utility of PRU value. Furthermore, the optimal PRU cut-off value varied with studies. One reason may be that the endpoints and observation periods differed, depending on the study. This study aimed to investigate the optimal cut-off and predictive ability of the PRU value for predicting cardiovascular events, while considering different endpoints and observatio

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Hikal, T., A. Hassouna, H. Ashour, and A. Tarek. "Major Adverse Cardiac Events after first time elective isolated Coronary Artery." QJM: An International Journal of Medicine 113, Supplement_1 (2020). http://dx.doi.org/10.1093/qjmed/hcaa042.003.

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Abstract Background Major adverse cardiovascular events (MACE) are useful endpoints to evaluate cardiovascular outcomes. The aim of this study was to report our results in concordance with the expected improvement of records after using the online Research Electronic Data Capture (RedCap) software. Methods: We included patients who benefited from first time elective isolated coronary bypass grafting (CABG) at Ain-Shams university main hospital, in the period between April 2014 and April 2016; providing a minimum 2 years follow-up . Incidences, risk factors and independent predictors for MACE w

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Naseer, Usman, EMMANUEL FOHLE, Catherine Hajek, et al. "Abstract 15267: Differential Effect of Calcium Score on Major Adverse Cardiac Events in Men and Women." Circulation 148, Suppl_1 (2023). http://dx.doi.org/10.1161/circ.148.suppl_1.15267.

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Introduction: Coronary artery calcium (CAC) is well-validated for cardiovascular risk stratification. There are well-known gender differences in the presentation, diagnosis, and management of cardiac diseases that have been extensively studied in the past. To date, there have not been extensive studies to look at the differential effect of CAC score on major adverse cardiac events (MACE; defined as death, MI, stroke, or coronary revascularization) amongst men and women. The objective of our study is to look at this aspect. Methods/Results: Data were analyzed on a group of 1,380 patients who ha

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Aftab, Waqas, Shuja Rasool, Padmini Varadarajan, and Ramdas G. Pai. "Abstract 16874: Predictors of Major Adverse Cardiac Events in Renal Transplant Recipients." Circulation 124, suppl_21 (2011). http://dx.doi.org/10.1161/circ.124.suppl_21.a16874.

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Background: Renal transplantation has become the treatment of choice in end stage renal disease patients. Though the incidence of acute myocardial infarction is reduced after kidney transplant as compared to patients awaiting kidney transplant, major adverse cardiac events (MACE) are still common after renal transplant, especially in early post operative period. Methods: We reviewed medical records of 321 consecutive adult patients from our institution who received renal allograft transplantation between1995 and 2003. Details on cardiac risk factors, medications, stress test results, coronary

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Akkaya, Fatih, Ahmet Kaya, Yasemin Kaya, Se Dereli, and Mehmet Filiz. "Association of Liver and Renal Function Impairment with Major Cardiac Events in Heart Failure Patients." Annals of Medical Research, 2023, 1. http://dx.doi.org/10.5455/annalsmedres.2023.03.069.

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Aim: We aimed to show whether liver and renal function tests impairment have an effect on cardiovascular major adverse events (MACE) in patients with chronic heart failure (CHF). MateriaL and Method: 514 Patients with Ejection Fraction (EF) 40% were screened retrospectively. Biochemical and hemogram parameters of the patients at the first admission were recorded. GFRs were calculated with the MDRD formula. Patients were classified into four groups based on whether they had just a kidney injury, only a liver damage, both a kidney and liver injury, or neither a kidney and liver injury. Exitus, s

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Garcia, Michael Cristian, Kai La Tsang, Simran Lohit, et al. "Hydroxychloroquine-Chloroquine, QT-Prolongation, and Major Adverse Cardiac Events: A Meta-analysis and Scoping Review." Annals of Pharmacotherapy, October 26, 2023. http://dx.doi.org/10.1177/10600280231204969.

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Objectives: We aimed to evaluate the high-quality literature on the frequency and nature of major adverse cardiac events (MACE) associated with either hydroxychloroquine (HCQ) or chloroquine (CQ). Data sources: We searched Medline, Embase, International Pharmaceutical Abstracts, and Cochrane Central from 1996 onward using search strategies created in collaboration with medical science librarians. Study selection and data extraction: Randomized controlled trials (RCTs) published in English language from January 1996 to September 2022, involving adult patients at least 18 years of age, were sele

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Kim, W., and H. S. Hwang. "Renal hyperfiltration as risk factor of major adverse cardiovascular events in patients with acute myocardial infarction." European Heart Journal 45, Supplement_1 (2024). http://dx.doi.org/10.1093/eurheartj/ehae666.3268.

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Abstract Objectives While the interaction between heart and kidney potentially contributes the development of renal hyperfiltration (RHF), its clinical consequence of is not clear in patients with acute myocardial infarction (AMI). Methods A total of 9,561 AMI patients with estimated GFR (eGFR) ≥60 mL/min/1.73 m² were enrolled from a large nationwide, multi-center, prospective, observational cohort between November 2011 and December 2015. RHF was defined as eGFR &gt;90th percentile after multiple adjustments. The primary endpoint was a combination of 3-year major adverse cardiovascular eve

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Qiao, Edmund M., John He, Katrina D. Silos, et al. "Baseline atrial volume indices and major adverse cardiac events following thoracic radiotherapy." Frontiers in Cardiovascular Medicine 12 (June 3, 2025). https://doi.org/10.3389/fcvm.2025.1560922.

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IntroductionPatients receiving thoracic radiotherapy (RT) have an increased risk of major adverse cardiac events (MACE) posttreatment. We utilized machine learning (ML) to discover novel predictors of MACE and validated them on an external cohort.MethodsThis multi-institutional retrospective study included 984 patients [n = 803 non-small cell lung cancer (NSCLC), n = 181 breast cancer] treated with radiotherapy. Extreme gradient boosting was utilized to discover novel clinical, dosimetric, and anatomical features (CT-based cardiac substructure segmentations) associated with MACE in a cohort of

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