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Journal articles on the topic 'Major adverse lower limb events'

Author: Grafiati

Published: 7 September 2024

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1

Bonaca, Marc P., Naomi M. Hamburg, and Mark A. Creager. "Contemporary Medical Management of Peripheral Artery Disease." Circulation Research 128, no. 12 (2021): 1868–84. http://dx.doi.org/10.1161/circresaha.121.318258.

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Peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis. Modifiable risk factors including cigarette smoking, dyslipidemia, diabetes, poor diet quality, obesity, and physical inactivity, along with underlying genetic factors contribute to lower extremity atherosclerosis. Patients with PAD often have coexistent coronary or cerebrovascular disease, and increased likelihood of major adverse cardiovascular events, including myocardial infarction, stroke and cardiovascular death. Patients with PAD often have reduced walking capacity and are at risk of acute and chronic critic

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2

Stone, Patrick A., Stephanie N. Thompson, David Williams, et al. "Biochemical markers in patients with open reconstructions with peripheral arterial disease." Vascular 24, no. 5 (2016): 461–68. http://dx.doi.org/10.1177/1708538115611302.

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The purpose of our study was to determine outcome differences as a function of baseline high-sensitivity C-reactive protein (hsCRP) and B-type natriuretic peptide (BNP) levels in patients receiving lower extremity open reconstructions for the treatment of peripheral arterial occlusive disease. We retrospectively examined patients who underwent surgical reconstructions performed by a single operator during a seven-year time span who received preoperative hsCRP and BNP testing and post-procedure imaging. Outcomes of interest included major adverse limb events, a composite end point of target ves

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3

Guédon, Alexis F., Jean-Baptiste De Freminville, Tristan Mirault, et al. "Association of Lipoprotein(a) Levels With Incidence of Major Adverse Limb Events." JAMA Network Open 5, no. 12 (2022): e2245720. http://dx.doi.org/10.1001/jamanetworkopen.2022.45720.

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ImportanceHigh lipoprotein(a) (Lp[a]) levels are involved in the development of cardiovascular events, particularly in myocardial infarction, stroke, and peripheral artery disease. Studies assessing the Lp(a) levels associated with adverse lower-limb events are lacking.ObjectiveTo assess the association between Lp(a) levels and incidence of major adverse limb events in unselected hospitalized patients.Design, Setting, and ParticipantsThis large retrospective monocentric cohort study was conducted from January 1, 2000, to December 31, 2020. Data were derived from the clinical information system

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Fashandi, Anna Z., J. Hunter Mehaffey, Robert B. Hawkins, Irving L. Kron, Gilbert R. Upchurch, and William P. Robinson. "Major adverse limb events and major adverse cardiac events after contemporary lower extremity bypass and infrainguinal endovascular intervention in patients with claudication." Journal of Vascular Surgery 68, no. 6 (2018): 1817–23. http://dx.doi.org/10.1016/j.jvs.2018.06.193.

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Mehaffey, James H., Robert Hawkins, Anna Fashandi, et al. "Lower Extremity Bypass Is Associated with Lower Short-Term Major Adverse Limb Events and Equivalent Major Adverse Cardiac Events Compared with Endovascular Intervention in A National Cohort with Critical Limb Ischemia." Journal of Vascular Surgery 65, no. 1 (2017): e4-e5. http://dx.doi.org/10.1016/j.jvs.2016.10.018.

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Habib, Salim, Othman Abdul-Malak, Michael Madigan, Karim Salem, and Mohammad Eslami. "Completion Imaging Use After Lower Extremity Bypass and Association With Major Adverse Limb Events." Journal of Vascular Surgery 76, no. 3 (2022): e40-e41. http://dx.doi.org/10.1016/j.jvs.2022.06.070.

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7

Singh, Kuldeep, Amandeep Juneja, Tushar Bajaj, et al. "Single Tertiary Care Center Outcomes After Lower Extremity Cadaveric Vein Bypass for Limb Salvage." Vascular and Endovascular Surgery 54, no. 5 (2020): 430–35. http://dx.doi.org/10.1177/1538574420925586.

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Objective: Cadaveric saphenous vein (CV) conduits are used in rare instances for limb salvage in patients without autogenous veins although long-term outcome data are scarce. This study was designed to evaluate the outcomes of CV bypass in patients with threatened limbs. Methods: We retrospectively reviewed the charts from 2010 to 2017 of 25 patients who underwent 30 CV allografts for critical limb ischemia and acute limb ischemia. Patient charts were reviewed for demographics, comorbidities, smoking status, indications for bypass, and outcomes. Primary outcomes included graft patency, major a

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Niiranen, Oskari, Juha Virtanen, Ville Rantasalo, Amer Ibrahim, Maarit Venermo, and Harri Hakovirta. "The Association between Major Adverse Cardiovascular Events and Peripheral Artery Disease Burden." Journal of Cardiovascular Development and Disease 11, no. 6 (2024): 157. http://dx.doi.org/10.3390/jcdd11060157.

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Objective: The aim of the present study was to investigate the possible relationship between the segmental burden of lower limb atherosclerosis and Major Adverse Cardiovascular Events (MACEs). Methods: All the consecutive symptomatic peripheral artery disease (PAD) patients admitted for digital subtraction angiography (DSA) at Turku University Hospital department of Vascular Surgery between 1 January 2009 and 30 July 2011 were retrospectively analyzed. Angiography due to symptomatic PAD was used as the index date for the inclusion in the study. The segmental burden of atherosclerosis based on

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Mehaffey, J. Hunter, Robert B. Hawkins, Anna Fashandi, et al. "Lower extremity bypass for critical limb ischemia decreases major adverse limb events with equivalent cardiac risk compared with endovascular intervention." Journal of Vascular Surgery 66, no. 4 (2017): 1109–16. http://dx.doi.org/10.1016/j.jvs.2017.04.036.

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Sunitha Therese, S., and N. Gayathri. "LOWER EXTREMITY PHERIPHERALARTERIAL DISEASE - AN UPDATE." International Journal of Advanced Research 10, no. 02 (2022): 1049–52. http://dx.doi.org/10.21474/ijar01/14311.

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Lower-extremity arterial disease (LEAD) is a major endemic disease with an alarming increased prevalence worldwide. It is a common and severe condition with excess risk of major cardiovascular events and death. It also leads to a high rate of lower-limb adverse events and non-traumatic amputation. The American Diabetes Association recommends a widespread medical history and clinical examination to screen for LEAD. The ankle brachial index (ABI) is the first non-invasive tool recommended to diagnose LEAD although its variable performance in patients with diabetes. The performance of ABI is part

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11

Lam, Alexander, Adam Schwertner, James Katrivesis, Dayantha Fernando, Kari Nelson, and Nadine Abi-Jaoudeh. "Atherectomy with balloon angioplasty compared to balloon angioplasty alone for the treatment of chronic limb threatening ischemia: A national surgical quality improvement program database analysis." Vascular 28, no. 6 (2020): 747–55. http://dx.doi.org/10.1177/1708538120932713.

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Objectives To compare perioperative outcomes related to atherectomy with percutaneous transluminal angioplasty versus percutaneous transluminal angioplasty alone for the treatment of lower extremity chronic limb threatening ischemia using a national patient database. Methods Patients with chronic limb threatening ischemia treated with atherectomy and percutaneous transluminal angioplasty or percutaneous transluminal angioplasty alone from 2011 to 2016 in the National Surgical Quality Improvement Program database were identified. Primary outcomes were major adverse limb events (30-day untreated

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Krzanowski, Marek, and Lukasz Partyka. "Regarding “Lower extremity bypass for critical limb ischemia decreases major adverse limb events with equivalent cardiac risk compared with endovascular intervention”." Journal of Vascular Surgery 67, no. 5 (2018): 1637. http://dx.doi.org/10.1016/j.jvs.2017.12.024.

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13

Shah, Aangi J., Nicholas Pavlatos, and Dinesh K. Kalra. "Preventive Therapies in Peripheral Arterial Disease." Biomedicines 11, no. 12 (2023): 3157. http://dx.doi.org/10.3390/biomedicines11123157.

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Atherosclerosis, while initially deemed a bland proliferative process, is now recognized as a multifactorial-lipoprotein-mediated inflammation-driven pathway. With the rising incidence of atherosclerotic disease of the lower extremity arteries, the healthcare burden and clinical morbidity and mortality due to peripheral artery disease (PAD) are currently escalating. With a healthcare cost burden of over 21 billion USD and 200 million patients afflicted worldwide, accurate knowledge regarding the pathophysiology, presentation, and diagnosis of the disease is crucial. The role of lipoproteins an

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Pomozi, Enikő, Rita Nagy, Péter Fehérvári, et al. "Direct Oral Anticoagulants as the First Choice of Anticoagulation for Patients with Peripheral Artery Disease to Prevent Adverse Vascular Events: A Systematic Review and Meta-Analysis." Journal of Cardiovascular Development and Disease 10, no. 2 (2023): 65. http://dx.doi.org/10.3390/jcdd10020065.

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The best method of anticoagulation for patients with peripheral artery disease (PAD) is still a topic of interest for physicians. We conducted a meta-analysis to compare the effects of direct oral anticoagulants (DOACs) with those of vitamin-K-antagonist (VKA) anticoagulants in patients with peripheral artery disease. Five databases (Medline (via PubMed), EMBASE, Scopus, Web of Science, and CENTRAL) were searched systematically for studies comparing the effects of the two types of anticoagulants in patients with PAD, with an emphasis on lower-limb outcomes, cardiovascular events, and mortality

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Latz, Christopher Alan, Laura Boitano, Linda J. Wang, et al. "Contemporary Endovascular 30-Day Outcomes for Critical Limb Threatening Ischemia Relative to Surgical Bypass Grafting." Vascular and Endovascular Surgery 55, no. 5 (2021): 441–47. http://dx.doi.org/10.1177/1538574421989516.

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Objectives: Data from 2011-2014 showed lower extremity bypass(LEB) outperforming infrainguinal endovascular intervention(IEI) regarding major adverse limb events(MALE) but noted no significant difference in major adverse cardiac events(MACE) in propensity matched cohorts. This study aimed to determine if more recent(2015-2018) endovascular outcomes data have improved relative to surgical bypass. Methods: Patients who underwent intervention for chronic limb threatening ischemia (CLTI) from 2015-2018 were identified using the American College of Surgeons National Quality Improvement Program(NSQI

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Rogers, R. Kevin, Manesh Patel, Mark Nehler, et al. "TCT-243 Early Risk of Major Adverse Limb Events Following Lower Extremity Revascularization in the VOYAGER-PAD Trial." Journal of the American College of Cardiology 82, no. 17 (2023): B95. http://dx.doi.org/10.1016/j.jacc.2023.09.250.

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17

Hiatt, William R., Marc P. Bonaca, Manesh R. Patel, et al. "Rivaroxaban and Aspirin in Peripheral Artery Disease Lower Extremity Revascularization." Circulation 142, no. 23 (2020): 2219–30. http://dx.doi.org/10.1161/circulationaha.120.050465.

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Background: The VOYAGER PAD trial (Vascular Outcomes Study of ASA Along With Rivaroxaban in Endovascular or Surgical Limb Revascularization for Peripheral Artery Disease) demonstrated superiority of rivaroxaban plus aspirin versus aspirin to reduce major cardiac and ischemic limb events after lower extremity revascularization. Clopidogrel is commonly used as a short-term adjunct to aspirin after endovascular revascularization. Whether clopidogrel modifies the efficacy and safety of rivaroxaban has not been described. Methods: VOYAGER PAD was a phase 3, international, double-blind, placebo-cont

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Rannelli, Luke, Eric Kaplovitch, and Sonia Anand. "Oral Hypoglycemics in Patients with type 2 Diabetes and Peripheral Artery Disease." Canadian Journal of General Internal Medicine 14, no. 2 (2019): 13–17. http://dx.doi.org/10.22374/cjgim.v14i2.282.

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Worldwide, in 2010, 202 million people were living with PAD, with a prevalence between 3-12 percent. The prevalence of PAD is three times greater in diabetic patients compared to those with normal glycaemia. PAD of the limbs is associated with increased cardiovascular morbidity and mortality, as well as major adverse limb events including acute limb ischemia and amputation. These risks are particularly high in patients who smoke and/or have type 2 diabetes. The goal of treatment in diabetic patients with PAD is to prevent cardiovascular events and prevent further peripheral artery stenosis lea

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19

Tsai, Shang-Yu, Ying-Sheng Li, Che-Hsiung Lee, et al. "Mono or Dual Antiplatelet Therapy for Treating Patients with Peripheral Artery Disease after Lower Extremity Revascularization: A Systematic Review and Meta-Analysis." Pharmaceuticals 15, no. 5 (2022): 596. http://dx.doi.org/10.3390/ph15050596.

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The efficacy of dual antiplatelet therapy (DAPT) for patients with peripheral artery disease (PAD) after lower-limb intervention remains controversial. Currently, the prescription of DAPT after an intervention is not fully recommended in guidelines due to limited evidence. This study compares and analyzes the prognosis for symptomatic PAD patients receiving DAPT versus monotherapy after lower-limb revascularization. Up to November 2021, PubMed/MEDLINE, Embase, and Cochrane databases were searched to identify studies reporting the efficacy, duration, and bleeding complications when either DAPT

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O'Donnell, Thomas F. X., Sarah E. Deery, Jeremy D. Darling, et al. "Adherence to lipid management guidelines is associated with lower mortality and major adverse limb events in patients undergoing revascularization for chronic limb-threatening ischemia." Journal of Vascular Surgery 66, no. 2 (2017): 572–78. http://dx.doi.org/10.1016/j.jvs.2017.03.416.

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St. Hilaire, Cynthia. "Medial Arterial Calcification: A Significant and Independent Contributor of Peripheral Artery Disease." Arteriosclerosis, Thrombosis, and Vascular Biology 42, no. 3 (2022): 253–60. http://dx.doi.org/10.1161/atvbaha.121.316252.

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Over 200 million individuals worldwide are estimated to have peripheral artery disease (PAD). Although the term peripheral can refer to any outer branch of the vasculature, the focus of this review is on lower-extremity arteries. The initial sequelae of PAD often include movement-induced cramping pain in the hips and legs or loss of hair and thinning of the skin on the lower limbs. PAD progresses, sometimes rapidly, to cause nonhealing ulcers and critical limb ischemia which adversely affects mobility and muscle tone; acute limb ischemia is a medical emergency. PAD causes great pain and a high

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Bérczi, Ákos, Dat Tin Nguyen, Hunor Sarkadi, et al. "Amputation and mortality rates of patients undergoing upper or lower limb surgical embolectomy and their predictors." PLOS ONE 17, no. 12 (2022): e0279095. http://dx.doi.org/10.1371/journal.pone.0279095.

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Purpose To provide information on the outcomes of upper and lower limb surgical embolectomies and the factors influencing amputation and mortality. Methods A retrospective, single-center analysis of 347 patients (female, N = 207; male, N = 140; median age, 76 years [interquartile range {IQR}, 63.2–82.6 years]) with acute upper or lower limb ischemia due to thromboembolism who underwent surgery between 2005 and 2019 was carried out. Patient demographics, comorbidities, medical history, the severity of acute limb ischemia (ALI), preoperative medication regimen, embolus/thrombus localization, pro

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Singh, Gagan D., Ehrin J. Armstrong, Stephen W. Waldo, et al. "Non-compressible ABIs are associated with an increased risk of major amputation and major adverse cardiovascular events in patients with critical limb ischemia." Vascular Medicine 22, no. 3 (2017): 210–17. http://dx.doi.org/10.1177/1358863x16689831.

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Ankle–brachial indices (ABIs) are important for the assessment of disease burden among patients with peripheral artery disease. Although low values have been associated with adverse clinical outcomes, the association between non-compressible ABI (ncABI) and clinical outcome has not been evaluated among patients with critical limb ischemia (CLI). The present study sought to compare the clinical characteristics, angiographic findings and clinical outcomes of those with compressible (cABI) and ncABI among patients with CLI. Consecutive patients undergoing endovascular evaluation for CLI between 2

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Hageman, Steven H. J., Gert Jan de Borst, Johannes A. N. Dorresteijn, et al. "Cardiovascular risk factors and the risk of major adverse limb events in patients with symptomatic cardiovascular disease." Heart 106, no. 21 (2020): 1686–92. http://dx.doi.org/10.1136/heartjnl-2019-316088.

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AimTo determine the relationship between non-high-density lipoprotein cholesterol (non-HDL-c), systolic blood pressure (SBP) and smoking and the risk of major adverse limb events (MALE) and the combination with major adverse cardiovascular events (MALE/MACE) in patients with symptomatic vascular disease.MethodsPatients with symptomatic vascular disease from the Utrecht Cardiovascular Cohort - Secondary Manifestations of ARTerial disease (1996–2017) study were included. The effects of non-HDL-c, SBP and smoking on the risk of MALE were analysed with Cox proportional hazard models stratified for

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Davis, Sarah, Steve Goodacre, Abdullah Pandor, et al. "009 Decision-analysis modelling of the effects of thromboprophylaxis for people with lower limb immobilisation for injury." Emergency Medicine Journal 36, no. 12 (2019): 776–77. http://dx.doi.org/10.1136/emermed-2019-rcem.9.

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BackgroundPharmacological thromboprophylaxis reduces the risk of symptomatic venous thromboembolism (VTE) in people with lower limb immobilisation due to injury but can increase the risk of bleeding. We used decision-analytic modelling to compare the risks and benefits of thromboprophylaxis and determine the overall benefit of treatment.Method and resultsA decision-analytic model was developed to simulate the management of a cohort of people with lower limb immobilisation due to injury according to different thromboprophylaxis strategies, including thromboprophylaxis for all and thromboprophyl

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De Matteis, Giuseppe, Federico Biscetti, Davide Antonio Della Polla, et al. "Sex-Based Differences in Clinical Characteristics and Outcomes among Patients with Peripheral Artery Disease: A Retrospective Analysis." Journal of Clinical Medicine 12, no. 15 (2023): 5094. http://dx.doi.org/10.3390/jcm12155094.

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Peripheral arterial disease (PAD) is a prevalent medical condition associated with high mortality and morbidity rates. Despite the high clinical burden, sex-based differences among PAD patients are not well defined yet, in contrast to other atherosclerotic diseases. This study aimed to describe sex-based differences in clinical characteristics and outcomes among hospitalized patients affected by PAD. This was a retrospective study evaluating all patients with a diagnosis of PAD admitted to the Emergency Department from 1 December 2013 to 31 December 2021. The primary endpoint of the study was

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Ipema, Jetty, Rutger H. A. Welling, Olaf J. Bakker, Reinoud P. H. Bokkers, Jean-Paul P. M. de Vries, and Çagdas Ünlü. "Short-Term Clinical Outcomes of Single Versus Dual Antiplatelet Therapy after Infrainguinal Endovascular Treatment for Peripheral Arterial Disease." Journal of Clinical Medicine 9, no. 11 (2020): 3515. http://dx.doi.org/10.3390/jcm9113515.

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After infrainguinal endovascular treatment for peripheral arterial disease (PAD), it is uncertain whether single antiplatelet therapy (SAPT) or dual antiplatelet therapy (DAPT) should be preferred. This study investigated major adverse limb events (MALE) and major adverse cardiovascular events (MACE) between patients receiving SAPT and DAPT. Patient data from three centers in the Netherlands were retrospectively collected and analyzed. All patients treated for PAD by endovascular revascularization of the superficial femoral, popliteal, or below-the-knee (BTK) arteries and who were prescribed a

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Djahanpour, Niousha, Naiyara Ahsan, Ben Li, et al. "A Systematic Review of Interleukins as Diagnostic and Prognostic Biomarkers for Peripheral Artery Disease." Biomolecules 13, no. 11 (2023): 1640. http://dx.doi.org/10.3390/biom13111640.

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Background: Peripheral artery disease (PAD) involves atherosclerosis of the lower extremity arteries and is a major contributor to limb loss and death worldwide. Several studies have demonstrated that interleukins (ILs) play an important role in the development and progression of PAD; however, a comprehensive literature review has not been performed. Methods: A systematic review was conducted and reported according to PRISMA guidelines. MEDLINE was searched from inception to 5 December 2022, and all studies assessing the association between ILs and PAD were included. Results: We included 17 st

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Alsheef, Mohammed Abdullah, Sam Schulman, Marco Donadini, and Abdul Rehman Z. Zaidi. "Venous Thromboembolism in Lower Extremity Amputees: A Systematic Review of the Literature." Blood 134, Supplement_1 (2019): 4980. http://dx.doi.org/10.1182/blood-2019-130751.

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Patients undergoing lower extremity amputation (LEA) are at risk of developing deep venous thrombosis (DVT) and pulmonary embolism (PE), but no generally accepted prevention guidelines exist. This systematic review aimed at understanding the incidence of VTE with or without thromboprophylaxis in adult patients with major lower extremity amputation (LEA). Primary outcomes were onset of DVT, PE, or mortality. Secondary outcomes were any major adverse events due to treatment. We searched English language full-text papers in multiple databases using keywords, including amputation/adverse effects,

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Suzuki, Kenji, Yukiko Mizutani, Yoshimitsu Soga, et al. "Efficacy and Safety of Endovascular Therapy for Aortoiliac TASC D Lesions." Angiology 68, no. 1 (2016): 67–73. http://dx.doi.org/10.1177/0003319716638005.

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Background: Although there is increasing evidence of the effectiveness of endovascular therapy for complex aortoiliac (AI) occlusive disease, it is not universally applied to TASC D lesions. Methods: A total of 2096 patients, 2601 limbs with AI occlusive disease, were enrolled. The lesions were categorized as TASC D (395) or TASC A-C (2206), and we compared baseline data, procedure, and follow-up result between the 2 groups. Results: The success rate of the procedure was significantly lower in the TASC D group (91.6% vs 99.3%, P < .01), and more procedure complications occurred in the TASC

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Singh, Satinder, Ehrin J. Armstrong, Walid Sherif, et al. "Association of elevated fasting glucose with lower patency and increased major adverse limb events among patients with diabetes undergoing infrapopliteal balloon angioplasty." Vascular Medicine 19, no. 4 (2014): 307–14. http://dx.doi.org/10.1177/1358863x14538330.

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Sullivan, Alexander E., and Joshua A. Beckman. "Medical Management of Peripheral Artery Disease." Seminars in Interventional Radiology 40, no. 02 (2023): 119–28. http://dx.doi.org/10.1055/s-0043-57257.

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AbstractPeripheral artery disease (PAD) is a common type of atherosclerotic disease of the lower extremities associated with reduced quality of life and ambulatory capacity. Major adverse cardiovascular events and limb amputations are the leading cause of morbidity and mortality in this population. Optimal medical therapy is therefore critical in these patients to prevent adverse events. Risk factor modifications, including blood pressure control and smoking cessation, in addition to antithrombotic agents, peripheral vasodilators, and supervised exercise therapy are key pillars of medical ther

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Prouse, Andrew F., Paula Langner, Mary E. Plomondon, et al. "Temporal trends in the management and clinical outcomes of lower extremity arterial thromboembolism within a national Veteran population." Vascular Medicine 24, no. 1 (2018): 41–49. http://dx.doi.org/10.1177/1358863x18793210.

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Lower extremity arterial thromboembolism is associated with significant morbidity and mortality. We sought to establish temporal trends in the incidence, management and outcomes of lower extremity arterial thromboembolism within the Veterans Affairs Healthcare System (VAHS). We identified patients admitted to VAHS between 2003 and 2014 with a primary diagnosis of lower extremity arterial thromboembolism. Medical and procedural management were ascertained from pharmaceutical and administrative data. Subsequent rates of major adverse limb events (MALE), major adverse cardiovascular events (MACE)

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Lin, Cheng-Wei, Shih-Yuan Hung, Chung-Huei Huang, Jiun-Ting Yeh, and Yu-Yao Huang. "Diabetic Foot Infection Presenting Systemic Inflammatory Response Syndrome: A Unique Disorder of Systemic Reaction from Infection of the Most Distal Body." Journal of Clinical Medicine 8, no. 10 (2019): 1538. http://dx.doi.org/10.3390/jcm8101538.

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Diabetic foot infection (DFI) is a major complication of diabetic foot that lead to nontraumatic lower-extremity amputation (LEA). Such distal infection of the body having systemic inflammatory response syndrome (SIRS) is rarely reported. Consecutive patients treated for limb-threatening DFI in a major diabetic foot center in Taiwan were analyzed between the years 2014 to 2017. Clinical factors, laboratory data, perfusion, extent, depth, infection and sensation (PEDIS) wound score in 519 subjects with grade 3 DFI and 203 presenting SIRS (28.1%) were compared. Major LEA and in-hospital mortalit

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Canonico, Mario Enrico, Raffaele Piccolo, Marisa Avvedimento, et al. "Antithrombotic Therapy in Peripheral Artery Disease: Current Evidence and Future Directions." Journal of Cardiovascular Development and Disease 10, no. 4 (2023): 164. http://dx.doi.org/10.3390/jcdd10040164.

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Patients with peripheral artery disease (PAD) are at an increased risk of major adverse cardiovascular events, and those with disease in the lower extremities are at risk of major adverse limb events primarily driven by atherothrombosis. Traditionally, PAD refers to diseases of the arteries outside of the coronary circulation, including carotid, visceral and lower extremity peripheral artery disease, and the heterogeneity of PAD patients is represented by different atherothrombotic pathophysiology, clinical features and related antithrombotic strategies. The risk in this diverse population inc

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Gressler, L., D. Marinac-Dabic, S. Dosreis, P. Goodney, C. D. Mullins, and F. T. Shaya. "PMD21 The Association of Major Adverse LIMB Events and Combination Stent and Atherectomy in Patients Undergoing Revascularization for Lower Extremity Peripheral Artery Disease." Value in Health 24 (June 2021): S127. http://dx.doi.org/10.1016/j.jval.2021.04.619.

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Henke, Peter. "Re: Association of elevated fasting glucose with lower patency and increased major adverse limb events among patients with diabetes undergoing infrapopliteal balloon angioplasty." Vascular Medicine 19, no. 4 (2014): 315–16. http://dx.doi.org/10.1177/1358863x14542460.

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Rymer, Jennifer A., Hillary Mulder, Kim G. Smolderen, et al. "Association of Health Status Scores With Cardiovascular and Limb Outcomes in Patients With Symptomatic Peripheral Artery Disease: Insights From the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) Trial." Journal of the American Heart Association 9, no. 19 (2020). http://dx.doi.org/10.1161/jaha.120.016573.

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Background There are limited data on health status instruments in patients with peripheral artery disease and cardiovascular and limb events. We evaluated the relationship between health status changes and cardiovascular and limb events. Methods and Results In an analysis of the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) trial, we examined the characteristics of 13 801 patients by tertile of health status instrument scores collected in the trial (EuroQol 5‐Dimensions [EQ‐5D], EQ visual analog scale [VAS], and peripheral artery questionnaire). We assessed the

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Guedon, A., J. B. De Freminville, T. Mirault, et al. "Elevated Lipoprotein(a) levels increase Major Adverse Limb Event." European Heart Journal 43, Supplement_2 (2022). http://dx.doi.org/10.1093/eurheartj/ehac544.1980.

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Abstract Background High lipoprotein(a) levels are involved in the development of cardiovascular events, as particularly in myocardial infarction, stroke, and peripheral artery disease. Studies assessing prognostic values of lipoprotein(a) levels on the lower limbs are lacking. Purpose The aim of our study was to look after a relationship between the lipoprotein(a) level and the incidence of major adverse limb events (MALE) defined as major amputation, peripheral artery endovascular revascularization or peripheral artery bypass. Methods We included 16,513 patients with lipoprotein(a) measureme

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Kiani, Sarah, Usman Salahuddin, Haekyung Jeon Slaughter, Atif Mohammad, Emmanouil S. Brilakis, and Subhash Banerjee. "Abstract 511: Adverse Outcomes in Patients with Diabetes Mellitus Following Stenting for Lower Extremity Peripheral Arterial Disease." Arteriosclerosis, Thrombosis, and Vascular Biology 36, suppl_1 (2016). http://dx.doi.org/10.1161/atvb.36.suppl_1.511.

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Introduction: There is limited data on outcomes of percutaneous endovascular intervention for lower extremity peripheral artery disease (PAD) in patients with diabetes mellitus (DM). We assessed the hypothesis that patients with DM, in comparison to patients without DM, have higher rates of major adverse cardiovascular and limb events after lower extremity PAD stenting. Methods: 1,006 patients with primary stent implant procedures between January 2005 and October 2015 enrolled in the observational XLPAD registry (NCT01904851) were analyzed for 12 month major adverse cardiovascular events (MACE

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VOSGIN-DINCLAUX, VALÉRIAN, KAMEL MOHAMMEDI, and CAROLINE CARADU. "483-P: Predictors of Major Adverse Lower Limb Events for Chronic Arterial Trophic Disorders." Diabetes 71, Supplement_1 (2022). http://dx.doi.org/10.2337/db22-483-p.

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Background: Peripheral arterial disease (PAD) affects more than 200 million people with an ever-increasing prevalence. Faced with this public health issue, it seems crucial to take an interest in PAD management. In this study, we evaluated the predictors of major adverse lower limb events (MALEs) and wound healing following revascularization for chronic arterial trophic disorders in people with and without diabetes. Methods: This retrospective study included all patients with Rutherford-Becker stage 5 or 6 who required a minor amputation in combination with a revascularization procedure in our

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Jamil, Yasser, Joshua Huttler, Dana Alameddine, et al. "The Impact of Ejection Fraction on Major Adverse Limb Events After Lower Extremity Revascularization." Annals of Vascular Surgery, October 2023. http://dx.doi.org/10.1016/j.avsg.2023.08.009.

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Vosgin-Dinclaux, Valérian, Paul Bertucat, Loubna Dari, et al. "Predictors of major adverse lower limb events in patients with tissue loss secondary to critical limb-threatening ischemia." Cardiovascular Revascularization Medicine, February 2024. http://dx.doi.org/10.1016/j.carrev.2024.01.018.

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Bonaca, M., R. P. Giugliano, C. P. Cannon, et al. "Reduction in the risk of major adverse limb events with ezetimibe versus placebo in addition to statin therapy: insights from the IMPROVE IT trial." European Heart Journal 44, Supplement_2 (2023). http://dx.doi.org/10.1093/eurheartj/ehad655.2034.

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Abstract Background/Introduction Patients with peripheral artery disease (PAD) are at risk of developing progressive symptoms leading to revascularization as well as major adverse limb events such as critical limb ischemia and amputation. Recently, two trials of PCSK9 inhibitors, which lower both LDL-C and Lp(a) have demonstrated reductions in MALE and peripheral revascularization. Whether this benefit is present for other LDL-C lowering therapies has not been well described. Purpose To evaluate whether LDL-C lowering with ezetimibe reduces the risk of adverse limb events. Methods IMPROVE-IT r

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Tawil, Michael, Thomas S. Maldonado, Yuhe Xia, et al. "Response to clopidogrel in patients undergoing lower extremity revascularization." Vascular, May 19, 2022, 170853812211034. http://dx.doi.org/10.1177/17085381221103417.

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Objectives Clopidogrel is effective at decreasing cardiovascular events in patients with peripheral artery disease (PAD); however, its effect on limb outcomes are less known. This study investigated the variability in response to clopidogrel and its relationship with clinical limb outcomes. Methods Three hundred subjects were enrolled in the Platelet Activity and Cardiovascular Events (PACE) study prior to lower extremity revascularization, of whom 104 were on clopidogrel. Light transmission platelet aggregation was measured in response to ADP 2 [Formula: see text]m immediately prior to revasc

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Juneja, Amandeep, Melissa Garuthara, Sonia Talathi, Amit Rao, Gregg Landis, and Yana Etkin. "Predictors of poor outcomes after lower extremity revascularization for acute limb ischemia." Vascular, January 25, 2023, 170853812311542. http://dx.doi.org/10.1177/17085381231154290.

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Objectives Acute lower extremity ischemia is one of the most common emergencies in vascular surgery and is a cause of considerable morbidity and mortality. The goal of this study was to evaluate outcomes of revascularization for acute lower extremity ischemia and to determine factors associated with perioperative morbidity and mortality. Methods A total of 354 patients underwent urgent revascularization for acute lower extremity ischemia at an academic medical center between 2014 and 2019. A retrospective review of patients’ demographics, comorbidities, etiology and severity of limb ischemia,

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GUPTA, ASHISH, and ASHU RASTOGI. "1815-LB: Lower Limb Vascularity Indices for Major Adverse Limb Events and Mortality in Individuals with Diabetic Foot Ulcer." Diabetes 73, Supplement_1 (2024). http://dx.doi.org/10.2337/db24-1815-lb.

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Objectives: We aimed to assess correlation between baPWV and ABI, specifically role of baPWV in participants with normal ABI for major adverse limb events (MALE) and mortality in people with diabetes and first diabetic foot ulcer (DFU). Research Design and Methods: A total of 16000 patients with type 2 diabetes were screened and 2186 individuals followed until 31st December 2022 or the time of death, whichever occurred earlier. A detailed demographic and diabetes complications were recorded. Whole cohort was divided into three groups based on the presenting ABI: group A: ABI 0.7-0.9, group B-A

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Amlani, Vishal, Karin Ludwigs, Aidin Rawshani, et al. "Major Adverse Limb Events in Patients Undergoing Revascularisation for Lower Limb Peripheral Arterial Disease: A Nationwide Observational Study★." European Journal of Vascular and Endovascular Surgery, August 2024. http://dx.doi.org/10.1016/j.ejvs.2024.07.041.

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Jamil, Yasser, Joshua Huttler, Dana Alameddine, et al. "Abstract 12311: The Impact of Ejection Fraction on Major Adverse Limb Events After Lower Extremity Revascularization." Circulation 146, Suppl_1 (2022). http://dx.doi.org/10.1161/circ.146.suppl_1.12311.

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Objective: Peripheral arterial disease (PAD) is commonly associated with cardiac disease and echocardiography is frequently performed prior to lower extremity revascularization (LER). However, the incidence of various echocardiographic findings and their impact on the outcomes of LER have not been well studied. Hypothesis: Low ejection fraction (EF) ≤ 40% is associated with increased major adverse limb events (MALE) after LER. Methods: The electronic records of patients undergoing LER in a single center were reviewed. Patients were divided based on the presence or absence of reduced EF ≤ 40%.

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Hsiao, Fu-Chih, Yi-Hsin Chan, Ying-Chang Tung, et al. "Visit-to-visit hemoglobin A1c variation and long-term risk of major adverse limb events in patients with type 2 diabetes." Journal of Clinical Endocrinology & Metabolism, April 6, 2023. http://dx.doi.org/10.1210/clinem/dgad203.

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Abstract Context Glycemic variation had been demonstrated to be associated with several complications of diabetes. Objective Investigation of the association between visit-to-visit hemoglobin A1c (HbA1c) variation and the long-term risk of major adverse limb events (MALEs). Design Retrospective database study. Average real variability was used to represent glycemic variations with all the HbA1c measurements during the 4 following years after the initial diagnosis of type 2 diabetes. Participants were followed from the beginning of the 5th year until death or the end of the follow-up. The assoc

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