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Relevant bibliographies by topics / Major histocompatibility complex class II (MHC-II) / Dissertations / Theses

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Dissertations / Theses on the topic 'Major histocompatibility complex class II (MHC-II)'

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Published: 4 June 2021

Last updated: 12 February 2022

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1

Qutob, Nouar. "Worldwide MHC class I and II diversity in humans." Thesis, University of Cambridge, 2011. https://www.repository.cam.ac.uk/handle/1810/252242.

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2

Brimpari, Minodora. "Regulation of MHC class I and II expression in mouse Epiblast stem cells." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609719.

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3

Keating, Paula. "Major histocompatibility complex class II expression on ovine T cells." Thesis, University of Edinburgh, 1995. http://hdl.handle.net/1842/30336.

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In this study the expression of MHC class II molecules on T cells from various immunological compartments of the sheep was examined. Monoclonal antibodies (mAbs) were characterized which react specifically with the homologues of human DRα and DQα molecules. The expression of these antigens was established on B cells and T cell subsets derived from peripheral blood, efferent lymph and afferent lymph. B cells from each of the lymphocyte sources expressed both DRα and DQα antigens. Variable expression on T cells was found. Each of the T cell subsets expressed both DR and DQ molecules at much high

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4

Wright, Harry. "Genes of the ovine major histocompatibility complex class II region." Thesis, University of Edinburgh, 1996. http://hdl.handle.net/1842/30049.

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As part of a study investigating fundamental cellular immunology in the sheep, this thesis describes the characterisation and expression of the genes of the sheep MHC class II region. Cosmid libraries prepared from DNA from three unrelated sheep were screened with probes from the <I>DP, DQ</I> and <I>DR</I> sub-regions of the human and mouse MHC class II regions. Cosmids were used because they facilitate the cloning of relatively large genomic inserts. Restriction maps of the cosmids have been produced showing that some of the clones overlapped. The MHC <I>A</I> and <I>B</I> genes within the c

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5

Shoukry, Mohamed Naglaa. "Study of the cellular factors affecting presentation of retroviral superantigens by Major Histocompatibility Complex (MHC) class II molecules." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0030/NQ64669.pdf.

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6

葉德俊 and Tak-chun Timothy Yip. "Characterization of a monoclonal antibody reactive against major histocompatibility complex class II antigens." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1992. http://hub.hku.hk/bib/B3123334X.

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7

Yip, Tak-chun Timothy. "Characterization of a monoclonal antibody reactive against major histocompatibility complex class II antigens /." [Hong Kong] : University of Hong Kong, 1992. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13478771.

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8

Lang, Heather. "T cell receptor crossreactivity with peptide : major histocompatibility complex class II ligands." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.418519.

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9

Parker, Aimée Dawn. "Classical and non-classical major histocompatibility complex class II genes in the chicken." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607817.

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10

Allen, Abigail E. "The Effects of a Set of Novel Compounds on Interferon-gamma Induced Major Histocompatibility Complex (MHC) Class II Molecules in Cultured Thyroid Cells." Ohio University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1534199427178941.

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11

Zavala-Ruiz, Zarixia 1977. "Structure studies of the human class II major histocompatibility complex protein HLA-DR1." Thesis, Massachusetts Institute of Technology, 2004. http://hdl.handle.net/1721.1/17842.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2004.<br>Vita.<br>Includes bibliographical references (leaves 149-162).<br>Major Histocompatibility Complex (MHC) proteins are heterodimeric membrane glycoproteins that bind antigens in the form of short peptides within the cell and present them to the T cell receptors on the surface T cells. In this thesis work, the structural aspects of the human class II MHC protein HLA-DR1 in complex with different peptides and also in the peptide-free form were investigated. Biochemical, crystallographic, and immunological analyse

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12

Barran, Paul Arthur. "The structure and transcription of a rat RT1 B alpha class II gene." Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26957.

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The major histocompatibility complex of the rat (RT1 complex) encodes two sets of class II molecules referred to as RT1 B and RT1 D. The RT1 Bα gene was isolated from a Sprague-Dawley (RT1b) rat genomic library using a rat RT1 Bα chain cDNA as a hybridization probe. The coding and the majority of the intron DNA sequence was determined. The structure of the RT1 Bα gene is equivalent to that of H-2 and HLA a chain genes. Comparison of the nucleotide and predicted amino acid sequences of the RT1 Bα gene to those of the H-2 and HLA genes revealed a high degree of overall sequence conservation. How

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13

Bhat, Kavita Purnanda. "Roles of the Ubiquitin-Proteasome System and Mono-ubiquitination in Regulating MHC class II Transcription." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/biology_diss/82.

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Major Histocompatibility Complex (MHC) class II molecules are indispensable arms of the im-mune system that present extracellular antigens to CD4+T cells and initiate the adaptive immune response. MHC class II expression requires recruitment of a master regulator, the class II trans-activator (CIITA). How this master transcriptional regulator is recruited, stabilized and degraded is unknown. The 26S proteasome, a master regulator of protein degradation, is a multi-subunit complex composed of a 20S core particle capped on one or both ends by 19S regulatory particles. Previous findings have link

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14

Beazley, Claude Andrew Fearn. "MUNCH : a prototype algorithm for predicting peptide binding to major histocompatibility complex class II proteins." Thesis, Birkbeck (University of London), 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.409229.

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15

Jackson, Amanda. "Genomic organisation and transcript identification in the class II region of the human major histocompatibility complex." Thesis, University College London (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.309171.

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16

Leon, Machado Jorge Alfonso. "Interaction between estrogen and interferon gamma signaling pathways in the regulation of major histocompatibility complex class ii expression in breast cancer cells." Mémoire, Université de Sherbrooke, 2017. http://hdl.handle.net/11143/9893.

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Abstract : Activation of the antigen presentation mechanisms by cancer cells is one of the main pathways used by the immune system for tumor detection and suppression. Induction of the expression of molecules of the Major Histocompatibility complex class II (MHC-II) by the interferon- (IFN) is important for the efficient presentation of tumor antigens. Nevertheless, it has been observed that expression of these molecules is supressed in tissular contexts where the concentration of estradiol (E2) is high. In this work we attempted to explain if the down-regulation exerted by estradiol on th

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17

Nguyen, Tina T. "Structural and Functional Studies of Proteins Involved in Antigen Processing: A Dissertation." eScholarship@UMMS, 2010. http://escholarship.umassmed.edu/gsbs_diss/503.

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This thesis is comprised of studies of proteins involved in class I and class II major histocompatibility complex (MHC) antigen procressing. In class I MHC processing, structural and functional studies were conducted of an aminopeptidase, ERAP1, that mediates the final step in antigen processing to understand how it is particularly suitable for cleavage of antigenic peptides for class I MHC presentation. In the class II MHC antigen presentation pathway, structural studies were conducted to characterize a fluorogenic peptide that can be used to understand peptide loading events in vivo and in r

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18

Florence, William Clinton. "Increased stability of class II MHC-peptide complexes in macrophages infected with mycobacterium avium and the examination of a novel role for cathepsin L in the innate immune response to Francisella Novicida infection." Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1173298339.

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19

Lapalombella, Silvana <1982&gt. "From Sanger to NGS: Detecting MHC (Major Histocompatibility Complex) Class II and OR (Olfactory Receptors) Genetic Variability in Italian Wolves (Canis Lupus) and relative Canids." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amsdottorato.unibo.it/7445/.

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In this PhD thesis I will describe different aspects of conservation genetics and genomics of two wild Canidae species, the wolf (Canis lupus) and the golden jackal (Canis aureus), through the study of two of the most variable gene families: the Major Histocompatibility Complex genes (MHC), and Olfactory Receptors genes (OR). In order to perform these studies both Sanger and next generation sequencing (NGS) DNA techniques have been used. The background of the thesis is described in the “General introduction” with phylogeny, classification and evolutionary ecology of the Canidae, with a focus o

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20

De, Riva A. "Role of major histocompatibility complex class II molecules in the maintenance of CD4 memory T cell function." Thesis, University College London (University of London), 2007. http://discovery.ucl.ac.uk/1446064/.

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The inheritable modifications that occur during activation enable memory T cells to mount a faster and stronger immune response than naive cells upon re-encounter with the same antigen. Memory CD4 T cells do not require MHC class II contact for survival, but previous analyses from our lab have underlined important differences between CD4 T cells transferred in MHC class II competent or deficient hosts that question the complete independency of memory cells from signals derived from MHC class II contact in terms of functionality. In this study, resting memory CD4 T cells generated in MHC class

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21

Andersson, Ida E. "Modified Glycopeptides Targeting Rheumatoid Arthritis : Exploring molecular interactions in class II MHC/glycopeptide/T-cell receptor complexes." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-42082.

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Rheumatoid arthritis (RA) is an autoimmune inflammatory disease that leads to degradation of cartilage and bone mainly in peripheral joints. In collagen-induced arthritis (CIA), a mouse model for RA, activation of autoimmune CD4+ T cells depends on a molecular recognition system where T-cell receptors (TCRs) recognize a complex between the class II MHC Aq protein and CII259-273, a glycopeptide epitope from type II collagen (CII). Interestingly, vaccination with the Aq/CII259-273 complex can relieve symptoms and cause disease regression in mice. This thesis describes the use of modified glycope

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22

Ekblom, Robert. "Immunoecology of the Great Snipe (Gallinago media) : Mate Choice, MHC Variation, and Humoral Immunocompetence in a Lekking Bird." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4585.

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23

Chang, Yea-wen. "Application of molecular genetic techniques to the study of major histocompatibility complex class II allelic associations with insulin-dependent diabetes mellitus in Chinese /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B18539919.

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24

Imlach, Stuart Nicolson. "Major histocompatibility complex class II molecules : importance in early T cell infiltration and use in the identification of immunologically relevant peptides." Thesis, University of Leicester, 1998. http://hdl.handle.net/2381/29569.

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Experiments have been performed to test the hypothesis that soluble HLA-DR-antigenic peptide complexes spontaneously released from antigen presenting cells might induce recruitment of antigen specific T cells as seen in early delayed type hypersensitivity reactions. Through the use of an enzyme-linked immunosorbent assay (ELISA) developed to measure soluble HLA-DR release, it was found that significant release did not occur from resting peripheral blood mononuclear cells (PBMC) until 5 days after the start of culture following cellular activation. In addition, release of soluble HLA-DR was pos

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25

Mehta, Ninad T. "Early Epigenetic Regulation of the Adaptive Immune Response Gene CIITA." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/biology_theses/24.

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The precise regulation of Major Histocompatibility class II (MHC-II) genes plays an important role in the control of the adaptive immune response. MHC-II genes are expressed constitutively in only a few cell types, but their expression can be induced by the inflammatory response cytokine interferon gamma (INF-γ). The regulation of MHC-II is controlled by a Master Regulator, the class II transactivator (CIITA). Multiple studies have shown that CIITA regulated expression of MHC-II is controlled and induced by INF-γ. It has been also shown that a functional CIITA gene is necessary for the express

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26

Koues, Olivia I. "The Epigenetic Regulation of Cytokine Inducible Mammalian Transcription by the 26S Proteasome." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/biology_diss/59.

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It is evident that components of the 26S proteasome function beyond protein degradation in the regulation of transcription. Studies in yeast implicate the 26S proteasome, specifically the 19S cap, in the epigenetic regulation of transcription. Saccharomyces cerevisiae 19S ATPases remodel chromatin by facilitating histone acetylation and methylation. However, it is unclear if the 19S ATPases play similar roles in mammalian cells. We previously found that the 19S ATPase Sug1 positively regulates transcription of the critical inflammatory gene MHC-II and that the MHC-II promoter fails to efficien

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27

Chang, Yea-wen, and 張雅雯. "Application of molecular genetic techniques to the study of major histocompatibility complex class II allelic associations with insulin-dependent diabetes mellitus in Chinese." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31213960.

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28

Murray, Brent William. "Major histocompatibility complex class II sequence variation in cetaceans : DQ[beta] and DR[beta] variation in beluga (Delphinapterus leucas) and DQ[beta] variation in North Atlantic right whales (Eubalaena glacialis) /." *McMaster only, 1997.

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29

Dasanayake, Dayal. "Identification of candidate Toxoplasma gondii factors that are responsible for the inhibition of interferon gamma mediated up-regulation of major histocompatibility complex class-II." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117163.

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The obligate intracellular pathogen Toxoplasma gondii is one of the most successful pathogens in the world, with an average worldwide infection rate of ~30 % in humans. The ability of the T. gondii to establish persistent infections in immunocompetent hosts is likely due to its immune evasion strategies that include interference with T cell activation, blocking of pro-inflammatory cytokine signaling while stimulating anti-inflammatory signaling and preventing the expression of major histocompatibility complex class II (MHC-II) molecules by immune cells. This blocking the production of MHC-II b

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30

Murray, Brent W. "Major Histocompatibility Complex class II sequence variation in cetaceans, DQß and DRß variation in beluga, Delphinapterus leucas, and DQß variation in north Atlantic right whales, Eubalaena glacialis." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape16/PQDD_0019/NQ30162.pdf.

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31

Yi, Zhang [Verfasser], Ingo [Akademischer Betreuer] Drexler, Klaus-Peter [Akademischer Betreuer] Janssen, and Anne [Akademischer Betreuer] Krug. "Characterization of Endogenous Major Histocompatibility Complex Class II Antigen Processing Pathways for Modified Vaccinia Virus Ankara Infection / Zhang Yi. Gutachter: Klaus-Peter Janssen ; Anne Krug. Betreuer: Ingo Drexler." München : Universitätsbibliothek der TU München, 2014. http://d-nb.info/1048677265/34.

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32

Wilson, Caitlin Persin. "The Expression of Major Histocompatibility Class I and Major Histocompatibility Class II on Macrophages in the Presence of Aryl Hydrocarbon Antagonist (CH-223191)." Wright State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=wright1472429222.

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33

Carven, Gregory J. (Gregory John) 1975. "Insight into the structure and function of empty class II major histocompatibility complexes." Thesis, Massachusetts Institute of Technology, 2002. http://hdl.handle.net/1721.1/17736.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, June 2004.<br>Vita.<br>Includes bibliographical references.<br>Class II major histocompatibility complex (MHC) proteins bind peptides and present them at the cell surface for interaction with CD4+ T cells as part of the system by which the immune system surveys the body for signs of infection. Peptide binding is known to induce conformational changes in class II MHC proteins on the basis of a variety of hydrodynamic and spectroscopic approaches, but the changes have not been clearly localized within the overall class I

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34

Gerhardt, Dawson. "The role of S7, a subunit of the 19S proteasome, in the transcriptional regulation of MHC II." unrestricted, 2006. http://etd.gsu.edu/theses/available/etd-11302006-232137/.

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Thesis (M.S.)--Georgia State University, 2006.<br>Title from title screen. Susanna Greer, committee chair; Delon Barfus,Yuan Liu, committee members. Electronic text (72 p. : ill.) : digital, PDF file. Description based on contents viewed Aug. 20, 2007. Includes bibliographical references (p. 69-72).

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35

Landais, Didier. "Analyse moleculaire des sites fonctionnels de la chaine a alpha du complexe majeur d'histocompatibilite murin." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13215.

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36

Schad, Julia. "Evolution of major histocompatibility complex genes in New World bats and their functional importance in parasite resistance and life-history decisions in the lesser bulldog bat (Noctilio albiventris)." Phd thesis, Universität Potsdam, 2012. http://opus.kobv.de/ubp/volltexte/2013/6351/.

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Immune genes of the major histocompatibility complex (MHC) constitute a central component of the adaptive immune system and play an essential role in parasite resistance and associated life-history strategies. In addition to pathogen-mediated selection also sexual selection mechanisms have been identified as the main drivers of the typically-observed high levels of polymorphism in functionally important parts of the MHC. The recognition of the individual MHC constitution is presumed to be mediated through olfactory cues. Indeed, MHC genes are in physical linkage with olfactory receptor genes a

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37

Houlihan, Josetta Lynn. "THE ROLE OF HSPs IN MHC CLASS II PRESENTATION OF SELECT ANTIGENS." Thesis, 2009. http://hdl.handle.net/1805/2046.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>The function of major histocompatability complex (MHC) class II molecules is to present antigenic peptides to CD4+ T cells. Typically, MHC class II molecules present peptides derived from exogenous sources. Yet, certain endogenous antigens (Ags) have been found to be presented by class II molecules. Studies suggest that specific heat shock protein family members may play a role in Ag processing and subsequent class II presentation. The studies presented here using B lymphoblasts demonstrate the importance of HSP90α, HSP90β, and possi

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38

Liu, Meng Ru, and 劉孟儒. "The role of major histocompatibility complex class II molecule(s) in tumor rejection." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/96884698675568398927.

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39

Kuntz, Steven. "Population Differentiation of Ontario Lake trout (Salvelinus namaycush) using the Major Histocompatibility Complex class II β gene". Thesis, 2014. http://hdl.handle.net/10012/8542.

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The lake trout (Salvelinus namaycush) is a coldwater salmonid with an extensive native distribution across formerly glaciated regions of North America. Lake trout are known to be a glacial ‘relict’ species and evolved as a result of glaciation events during the Pleistocene era. Historic and recent human activities along with climate change have had a significant influence on the phylogeographic and genetic compositions of current lake trout populations. Human activities like overexploitation, habitat degradation and most importantly stocking have had detrimental effects on the diversity and va

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40

Haylett, Romney [Verfasser]. "The characterization of major histocompatibility complex class II signal transduction pathways in antigen presenting cells / vorgelegt von Romney Haylett." 2009. http://d-nb.info/996828834/34.

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41

Feng, Gou Jin, and 馮國津. "The role of major histocompatibility complex class II -expressing infiltrates in the CD4 T cell-regulated early tumor neovascularization." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/80499004472216082220.

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碩士<br>長庚大學<br>生物醫學研究所<br>101<br>Neovascularization is essential for tumor progression. Although tumor neovessels are known to be under host CD4 T cell surveillance, what makes the neovessels susceptible to CD4 T immunity remains unclear. The aim of this study is to understand the relationship among tumor blood vessels, CD4 T cells and MHCII-expressing tumor infiltrates. Previously, we have established a transplantable tumor model driven by EBV oncogene N-LMP1 in the immunocompetent mice. In the model system, we found that N-LMP1 is immunogenic, capable to induce CD4 T cell immunity to inhibit

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42

Zadražil, Zdeněk. "Charakterizace imunitního systém s využitím MHC II/ EGFP knock-in myši." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-304812.

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The immune system is essential for keeping the integrity of multicellular organisms. We were able to make a step forward in studying the complex immune reactions in mammals in vivo and/ or in situ using the major histocompatibility complex (MHC) class II/ enhanced green fluorescent protein (EGFP) knock-in mouse model. Due to the EGFP visualization of MHC II expressing cells we were able to observe antigen presenting cells, which are essential for the onset of immune responses, in their natural environment. Thus, we report some original features of the immune system. We have identified MHC II+

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43

Hanson, Matthew Scott. "Molecular and cellular characterization of major histocompatibility complex class II I-E expression and pancreatic Beta cell autoimmunity in transgenic nonobese diabetic mice." 1995. http://catalog.hathitrust.org/api/volumes/oclc/33318518.html.

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44

Maganti, Nagini. "Role of 26S Proteasome and Regulator of G-Protein Signaling 10 in Regulating Neuroinflammation in the Central Nervous System." 2015. http://scholarworks.gsu.edu/biology_diss/162.

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Major histocompatibility complex molecules (MHCII) are cell surface glycoproteins that present extracellular antigens to CD4+ T lymphocytes and initiate adaptive immune responses. Apart from their protective role, overexpression of MHCII contributes to autoimmune disorders where the immune system attacks our own tissues. Autoimmune diseases are characterized by self-reactive responses to autoantigens, promoting tissue damage, inflammation mediated by proinflammatory cytokines, autoreactive lymphocytes, and autoantibodies. MHCII molecules are tightly regulated at the level of transcription by C

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Letendre, Corinne. "Effet de Streptococcus Suis sur la capacité de présentation antigénique de cellules dendritiques." Thèse, 2016. http://hdl.handle.net/1866/16144.

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Streptococcus suis est un important pathogène porcin et humain, causant méningites et septicémies. Des études suggèrent que S. suis dispose de facteurs de virulence, notamment sa capsule polysaccharidique (CPS), qui lui permettent de moduler les fonctions des cellules dendritiques (DCs), situées à l’interface entre l’immunité innée et adaptative. Les difficultés à développer un vaccin efficace suggèrent aussi une altération de la voie T dépendante. L’objectif général du projet était d’évaluer l’effet de S. suis sur l’activation des cellules T CD4+ ainsi que sur la capacité de présentation anti

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46

Croisetière, Sébastien. "Étude du polymorphisme du gène majeur d’histocompatibilité de classe IIb (MHIIb) chez l’omble de fontaine (Salvelinus fontinalis)." Thèse, 2009. http://hdl.handle.net/1866/3592.

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Les molécules classiques du complexe majeur d’histocompatibilité de classe II (CMHII) sont des glycoprotéines de surface spécialisées dans la présentation de peptides, principalement dérivés de pathogènes extracellulaires, aux récepteurs des lymphocytes T CD4+ afin d’initier la réponse immunitaire adaptative. Elles sont encodées, avec celles du CMH de classe I, par les gènes les plus polymorphiques identifiés jusqu’à maintenant, avec plusieurs loci et une grande diversité allélique à chacun d’eux. De plus, le polymorphisme des gènes du CMHII n’est pas limité qu’aux séquences codantes. Il est

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Osborn, Jodi. "Elucidation of Mechanisms Underlying Metastatic Melanoma Immune Escape via Suppression of Major Histocompatibility Complex (MHC) II through Dysregulation of the JAK/STAT Pathway." 2015. http://scholarworks.gsu.edu/biology_diss/155.

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Transcriptional activation of Major Histocompatability Complex (MHC) I and II molecules by the cytokine interferon gamma (IFN-g) is a key step in cell-mediated immunity against pathogens and tumors. Following IFN-g induction, JAK/STAT signaling triggers activation of MHC genes. Recent evidence suggests suppression of MHC I and II expression on multiple tumor types plays important roles in tumor immunoevasion. One such tumor is malignant melanoma, the leading cause of skin cancer related deaths. Despite awareness of MHC expression defects, the molecular mechanisms by which melanoma cells suppre

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Rodrigues, Leonor Nunes. "Unravelling the role of alpha 2,6 sialic acid on mouse dentritic cells functions." Master's thesis, 2015. http://hdl.handle.net/10362/15716.

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RESUMO: As células dendríticas (CDs) são fundamentais na imunomodulação e iniciação de respostas imunes adaptativas, enquanto os ácidos siálicos (Sias) são potenciais imunomoduladores. Estas células expressam níveis elevados da sialiltransferase ST6Gal-1, que transfere Sias para a posição terminal de oligossacáridos. De facto, a maturação de CDs está associada a uma diminuição da sialilação na sua superfície celular. Apesar de ter função biológica desconhecida, a forma solúvel, extracelular de ST6Gal-1 aumenta em cancros e inflamação. Ainda assim, esta foi recentemente identificada como modul

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