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Journal articles on the topic 'MAL3'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Charron, M. J., E. Read, S. R. Haut, and C. A. Michels. "Molecular evolution of the telomere-associated MAL loci of Saccharomyces." Genetics 122, no. 2 (1989): 307–16. http://dx.doi.org/10.1093/genetics/122.2.307.

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Abstract The MAL gene family of Saccharomyces consists of five multigene complexes (MAL1, MAL2, MAL3, MAL4, and MAL6) each of which encodes maltose permease (GENE 1), maltase (GENE 2) and the trans-acting MAL-activator (GENE 3). Four of these loci have been mapped and each is located at or near the telomere of a different chromosome. We compare the physical structure of the MAL loci and their flanking sequences. The MAL loci were shown to be both structurally and functionally homologous throughout an approximately 9.0-kb region. The orientation of the MAL loci was determined to be: CENTROMERE

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2

Ni, B. F., and R. B. Needleman. "Identification of the upstream activating sequence of MAL and the binding sites for the MAL63 activator of Saccharomyces cerevisiae." Molecular and Cellular Biology 10, no. 7 (1990): 3797–800. http://dx.doi.org/10.1128/mcb.10.7.3797-3800.1990.

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Maltose fermentation in Saccharomyces species requires the presence of at least one of five unlinked MAL loci: MAL1, MAL2, MAL3, MAL4, and MAL6. Each of these loci consists of a complex of genes involved in maltose metabolism; the complex includes maltase, a maltose permease, and an activator of these genes. At the MAL6 locus, the activator is encoded by the MAL63 gene. While the MAL6 locus has been the subject of numerous studies, the binding sites of the MAL63 activator have not been determined. In this study, we used Escherichia coli extracts containing the MAL63 protein to define the bindi

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3

Ni, B. F., and R. B. Needleman. "Identification of the upstream activating sequence of MAL and the binding sites for the MAL63 activator of Saccharomyces cerevisiae." Molecular and Cellular Biology 10, no. 7 (1990): 3797–800. http://dx.doi.org/10.1128/mcb.10.7.3797.

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Maltose fermentation in Saccharomyces species requires the presence of at least one of five unlinked MAL loci: MAL1, MAL2, MAL3, MAL4, and MAL6. Each of these loci consists of a complex of genes involved in maltose metabolism; the complex includes maltase, a maltose permease, and an activator of these genes. At the MAL6 locus, the activator is encoded by the MAL63 gene. While the MAL6 locus has been the subject of numerous studies, the binding sites of the MAL63 activator have not been determined. In this study, we used Escherichia coli extracts containing the MAL63 protein to define the bindi

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4

Asakawa, Kazuhide, Kazunori Kume, Muneyoshi Kanai та ін. "The V260I Mutation in Fission Yeast α-Tubulin Atb2 Affects Microtubule Dynamics and EB1-Mal3 Localization and Activates the Bub1 Branch of the Spindle Checkpoint". Molecular Biology of the Cell 17, № 3 (2006): 1421–35. http://dx.doi.org/10.1091/mbc.e05-08-0802.

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We have identified a novel temperature-sensitive mutant of fission yeast α-tubulin Atb2 (atb2-983) that contains a single amino acid substitution (V260I). Atb2-983 is incorporated into the microtubules, and their overall structures are not altered noticeably, but microtubule dynamics is compromised during interphase. atb2-983 displays a high rate of chromosome missegregation and is synthetically lethal with deletions in a subset of spindle checkpoint genes including bub1, bub3, and mph1, but not with mad1, mad2, and mad3. During early mitosis in this mutant, Bub1, but not Mad2, remains for a p

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5

Hoyer, Naomi K., and Jennifer E. Rawlinson. "Prevalence of Malocclusion of Deciduous Dentition in Dogs: An Evaluation of 297 Puppies." Journal of Veterinary Dentistry 36, no. 4 (2019): 251–56. http://dx.doi.org/10.1177/0898756420905136.

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A total of 297 dogs between 8 and 12 weeks of age were examined during a 1-year period to evaluate occlusion. Dogs were categorized either as individual dogs or members of a litter and purebred or mixed breed. Occlusion was evaluated by class: normal, class 1 malocclusion (MAL1), class 2 malocclusion (MAL2), or class 3 malocclusion (MAL3). Dogs with MAL3 were also subdivided based on whether MAL3 was considered a breed standard; dogs with breed standard MAL3 were considered under normal occlusion for statistical analyses. Malocclusions were further categorized as mild, moderate, or severe. Twe

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6

Beinhauer, Jens D., Iain M. Hagan, Johannes H. Hegemann, and Ursula Fleig. "Mal3, the Fission Yeast Homologue of the Human APC-interacting Protein EB-1 Is Required for Microtubule Integrity and the Maintenance of Cell Form." Journal of Cell Biology 139, no. 3 (1997): 717–28. http://dx.doi.org/10.1083/jcb.139.3.717.

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Through a screen designed to isolate novel fission yeast genes required for chromosome segregation, we have identified mal3+. The mal3-1 mutation decreased the transmission fidelity of a nonessential minichromosome and altered sensitivity to microtubule-destabilizing drugs. Sequence analysis revealed that the 35-kD Mal3 is a member of an evolutionary conserved protein family. Its human counterpart EB-1 was identified in an interaction screen with the tumour suppressor protein APC. EB-1 was able to substitute for the complete loss of the mal3+ gene product suggesting that the two proteins might

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7

Kerres, Anne, Corina Vietmeier-Decker, Jennifer Ortiz, et al. "The Fission Yeast Kinetochore Component Spc7 Associates with the EB1 Family Member Mal3 and Is Required for Kinetochore–Spindle Association." Molecular Biology of the Cell 15, no. 12 (2004): 5255–67. http://dx.doi.org/10.1091/mbc.e04-06-0443.

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A critical aspect of mitosis is the interaction of the kinetochore with spindle microtubules. Fission yeast Mal3 is a member of the EB1 family of microtubule plus-end binding proteins, which have been implicated in this process. However, the Mal3 interaction partner at the kinetochore had not been identified. Here, we show that the mal3 mutant phenotype can be suppressed by the presence of extra Spc7, an essential kinetochore protein associated with the central centromere region. Mal3 and Spc7 interact physically as both proteins can be coimmunoprecipitated. Overexpression of a Spc7 variant se

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8

Chen, Chang-Rung, Jing Chen, and Eric C. Chang. "A Conserved Interaction between Moe1 and Mal3 Is Important for Proper Spindle Formation in Schizosaccharomyces pombe." Molecular Biology of the Cell 11, no. 12 (2000): 4067–77. http://dx.doi.org/10.1091/mbc.11.12.4067.

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Moe1 is a conserved fission yeast protein that negatively affects microtubule stability/assembly. We conducted a two-hybrid screen to search for Moe1-binding proteins and isolated Mal3, a homologue of human EB1. We show that Moe1 and Mal3 expressed in bacteria form a complex and that Moe1 and Mal3 expressed in fission yeast cosediment with microtubules. Deletion of either moe1 ormal3 does not result in lethality; however, deletion of both moe1 and mal3 leads to cell death in the cold. The resulting cells appear to die of chromosome missegregation, which correlates with the presence of abnormal

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9

Braunstein, Marc J., Craig M. Scott, Shannon Behrman, et al. "Targeting Hsp70 in Multiple Myeloma Induces Synergistic Cytotoxicity with Inhibitors of the Proteasome and of Hsp90." Blood 112, no. 11 (2008): 5160. http://dx.doi.org/10.1182/blood.v112.11.5160.5160.

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Abstract Background: Multiple myeloma (MM) remains incurable, primarily due to the development of dose-limiting toxicity and/or resistance to previously effective drugs. A rational approach is to develop new strategies that are synergistic with existing agents. Recent research indicates that inhibition of the molecular chaperone heat shock protein (Hsp) 70 may facilitate resistance to inhibitors of cellular protein quality control such as bortezomib in MM. This is indicated by upregulation of Hsp70 expression after treatment of MM with inhibitors of the proteasome or Hsp90. Endothelial progeni

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10

Braunstein, M. J., C. M. Scott, S. Berman, et al. "In Vitro Antimyeloma Effects of Inhibitors of the Heat Shock Protein 70 (Hsp70) Molecular Chaperone." Blood 110, no. 11 (2007): 1524. http://dx.doi.org/10.1182/blood.v110.11.1524.1524.

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Abstract Background: Multiple myeloma (MM) remains incurable, primarily due to drug resistance; recent research indicates that Hsp70 induction may accompany this process. Cytoplasmic Hsp70 is upregulated in MM, particularly after proteasome or Hsp90 inhibition. Hsp70 homolog in the ER helps fold immunoglobulins whose overexpression and misassembly trigger the unfolded protein response (UPR). We thus explored the antimyeloma effects of MAL3-101, a recently developed Hsp70 inhibitor on MM cell lines, primary MM cells, and endothelial progenitor cells (EPCs), a key MM microenvironment component;

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11

Braunstein, Marc J., Sadeaqua S. Scott, Craig M. Scott, et al. "Antimyeloma Effects of the Heat Shock Protein 70 Molecular Chaperone Inhibitor MAL3-101." Journal of Oncology 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/232037.

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Multiple myeloma (MM) is the second most common hematologic malignancy and remains incurable, primarily due to the treatment-refractory/resistant nature of the disease. A rational approach to this compelling challenge is to develop new drugs that act synergistically with existing effective agents. This approach will reduce drug concentrations, avoid treatment resistance, and also improve treatment effectiveness by targeting new and nonredundant pathways in MM. Toward this goal, we examined the antimyeloma effects of MAL3-101, a member of a new class of non-ATP-site inhibitors of the heat shock

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12

Patham, Bhargavi, Josh Duffy, Ariel Lane, et al. "Post-translational import of protein into the endoplasmic reticulum of a trypanosome: an in vitro system for discovery of anti-trypanosomal chemical entities." Biochemical Journal 419, no. 2 (2009): 507–17. http://dx.doi.org/10.1042/bj20081787.

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HAT (human African trypanosomiasis), caused by the protozoan parasite Trypanosoma brucei, is an emerging disease for which new drugs are needed. Expression of plasma membrane proteins [e.g. VSG (variant surface glycoprotein)] is crucial for the establishment and maintenance of an infection by T. brucei. Transport of a majority of proteins to the plasma membrane involves their translocation into the ER (endoplasmic reticulum). Thus inhibition of protein import into the ER of T. brucei would be a logical target for discovery of lead compounds against trypanosomes. We have developed a TbRM (T. br

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13

Adam, Christian, Anne Baeurle, Jeffrey L. Brodsky, et al. "The HSP70 Modulator MAL3-101 Inhibits Merkel Cell Carcinoma." PLoS ONE 9, no. 4 (2014): e92041. http://dx.doi.org/10.1371/journal.pone.0092041.

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14

Asakawa, Kazuhide, and Takashi Toda. "Cooperation of EB1-Mal3 and the Bub1 Spindle Checkpoint." Cell Cycle 5, no. 1 (2005): 27–30. http://dx.doi.org/10.4161/cc.5.1.2262.

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15

Fang, Shijing, Anne L. Crews, Wei Chen, et al. "MARCKS and HSP70 interactions regulate mucin secretion by human airway epithelial cells in vitro." American Journal of Physiology-Lung Cellular and Molecular Physiology 304, no. 8 (2013): L511—L518. http://dx.doi.org/10.1152/ajplung.00337.2012.

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Myristoylated alanine-rich C kinase substrate (MARCKS) protein has been recognized as a key regulatory molecule controlling mucin secretion by airway epithelial cells in vitro and in vivo. We recently showed that two intracellular chaperones, heat shock protein 70 (HSP70) and cysteine string protein (CSP), associate with MARCKS in the secretory mechanism. To elucidate more fully MARCKS-HSP70 interactions in this process, studies were performed in well-differentiated normal human bronchial epithelial (NHBE) cells maintained in air-liquid interface culture utilizing specific pharmacological inhi

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16

Kerres, Anne, Visnja Jakopec, and Ursula Fleig. "The Conserved Spc7 Protein Is Required for Spindle Integrity and Links Kinetochore Complexes in Fission Yeast." Molecular Biology of the Cell 18, no. 7 (2007): 2441–54. http://dx.doi.org/10.1091/mbc.e06-08-0738.

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Spc7, a member of the conserved Spc105/KNL-1 family of kinetochore proteins, was identified as an interaction partner of the EB1 homologue Mal3. Spc7 associates with the central centromere region of the chromosome but does not affect transcriptional silencing. Here, we show that Spc7 is required for the integrity of the spindle as well as for targeting of MIND but not of Ndc80 complex components to the kinetochore. Spindle defects in spc7 mutants were severe ranging from the inability to form a bipolar spindle in early mitosis to broken spindles in midanaphase B. spc7 mutant phenotypes were pa

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17

Carlsson, A. E., and P. J. Meschter. "Relative stability of LI2, DO22, and DO23 structures in MAl3 compounds." Journal of Materials Research 4, no. 5 (1989): 1060–63. http://dx.doi.org/10.1557/jmr.1989.1060.

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The structural energy differences between cubic LI2 and tetragonal DO22 crystal structures are calculated for MAl3 compounds, where M is a group III, IV, or V transition metal. The stability of the DO22 structure relative to L12 increases rapidly as the transition-metal d-electron count increases. Typical values of E(DO22) – E(L12) are 0.1–0.15 eV/atom (9600–14500 J/g-atom) for group III,  0.05 eV/atom ( 4800 J/g-atom) for group IV, and ∼ –0.2 eV/atom (∼ –19000 J/g-atom) for group V trialuminides. Similar trends are calculated for the DO23/L12 energy difference. The calculated electronic den

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18

des Georges, Amédée, Miho Katsuki, Douglas R. Drummond, Michael Osei, Robert A. Cross, and Linda A. Amos. "Mal3, the Schizosaccharomyces pombe homolog of EB1, changes the microtubule lattice." Nature Structural & Molecular Biology 15, no. 10 (2008): 1102–8. http://dx.doi.org/10.1038/nsmb.1482.

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19

Vidgren, Virve, Laura Ruohonen, and John Londesborough. "Characterization and Functional Analysis of the MAL and MPH Loci for Maltose Utilization in Some Ale and Lager Yeast Strains." Applied and Environmental Microbiology 71, no. 12 (2005): 7846–57. http://dx.doi.org/10.1128/aem.71.12.7846-7857.2005.

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ABSTRACT Maltose and maltotriose are the major sugars in brewer's wort. Brewer's yeasts contain multiple genes for maltose transporters. It is not known which of these express functional transporters. We correlated maltose transport kinetics with the genotypes of some ale and lager yeasts. Maltose transport by two ale strains was strongly inhibited by other α-glucosides, suggesting the use of broad substrate specificity transporters, such as Agt1p. Maltose transport by three lager strains was weakly inhibited by other α-glucosides, suggesting the use of narrow substrate specificity transporter

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20

Carlsson, A. E., and P. J. Meschter. "Relative stabilities of L12 and DO22 structures in ternary MAl3-base aluminides." Journal of Materials Research 5, no. 12 (1990): 2813–18. http://dx.doi.org/10.1557/jmr.1990.2813.

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The effects of additions of Fe and Zn on the relative stabilities of the cubic L12 and tetragonal DO22 structures in TiAl3- and NbAl3-base alloys are evaluated using ab initio electronic band calculations. The Fe or Zn distribution on the aluminum sublattice is modeled by a periodic array which corresponds to alloying additions of 12.5 or 25 at.% Fe or Zn. Addition of 12.5 at.% Fe is sufficient to stabilize the L12 structure in both TiAl3- and NbAl3-base alloys. Interpolation of the structural energy differences suggests that the DO22 and L12 structures have the same energy at ∼4.5 at.% Fe in

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21

Katsuki, Miho, Douglas R. Drummond, Michael Osei, and Robert A. Cross. "Mal3 Masks Catastrophe Events inSchizosaccharomyces pombeMicrotubules by Inhibiting Shrinkage and Promoting Rescue." Journal of Biological Chemistry 284, no. 43 (2009): 29246–50. http://dx.doi.org/10.1074/jbc.c109.052159.

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22

Di Pietro, Paola, Rosario Lizio, Carmine Izzo, et al. "A Novel Combination of High-Load Omega-3 Lysine Complex (AvailOm®) and Anthocyanins Exerts Beneficial Cardiovascular Effects." Antioxidants 11, no. 5 (2022): 896. http://dx.doi.org/10.3390/antiox11050896.

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Omega-3 fatty acids have been shown to exert several beneficial effects in the prevention of cardiovascular and cerebrovascular diseases. The objective of the present study was to analyze the effects of a novel high-load omega-3 lysine complex, AvailOm®, its related constituents and a novel mixture of AvailOm® with specific vasoactive anthocyanins on vascular function in mice resistance artery. Pressure myograph was used to perform vascular reactivity studies. Nitric oxide and oxidative stress were assessed by difluorofluorescein diacetate and dihydroethidium, respectively. Increasing doses of

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23

Samolia, Madhu, and T. J. Dhilip Kumar. "Fundamental studies of H2 interaction with MAl3 clusters [M=Li, Sc, Ti, Zr]." Journal of Alloys and Compounds 588 (March 2014): 144–52. http://dx.doi.org/10.1016/j.jallcom.2013.10.147.

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24

Charron, M. J., and C. A. Michels. "The naturally occurring alleles of MAL1 in Saccharomyces species evolved by various mutagenic processes including chromosomal rearrangement." Genetics 120, no. 1 (1988): 83–93. http://dx.doi.org/10.1093/genetics/120.1.83.

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Abstract In order for a yeast strain to ferment maltose it must contain any one of the five dominant MAL loci. Each dominant MAL locus thus far analyzed contains three genes: GENE 1, encoding maltose permease, GENE 2 encoding maltase and GENE 3 encoding a positive trans-acting regulatory protein. In addition to these dominant MAL loci, several naturally occurring, partially functional alleles of MAL1 and MAL3 have been identified. Here, we present genetic and molecular analysis of the three partially functional alleles of MAL1: the MAL1p allele which can express only the MAL activator; the MAL

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25

Kerres, Anne, Visnja Jakopec, Christoph Beuter, et al. "Fta2, an Essential Fission Yeast Kinetochore Component, Interacts Closely with the Conserved Mal2 Protein." Molecular Biology of the Cell 17, no. 10 (2006): 4167–78. http://dx.doi.org/10.1091/mbc.e06-04-0264.

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The fission yeast multiprotein-component Sim4 complex plays a fundamental role in the assembly of a functional kinetochore. It affects centromere association of the histone H3 variant CENP-A as well as kinetochore association of the DASH complex. Here, multicopy suppressor analysis of a mutant version of the Sim4 complex component Mal2 identified the essential Fta2 kinetochore protein, which is required for bipolar chromosome attachment. Kinetochore localization of Mal2 and Fta2 depends on each other, and overexpression of one protein can rescue the phenotype of the mutant version of the other

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26

Asakawa, Kazuhide, Mika Toya, Masamitsu Sato, et al. "Mal3, the fission yeast EB1 homologue, cooperates with Bub1 spindle checkpoint to prevent monopolar attachment." EMBO reports 6, no. 12 (2005): 1194–200. http://dx.doi.org/10.1038/sj.embor.7400540.

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27

Naumov, G. I., E. S. Naumova, and C. A. Michels. "Genetic variation of the repeated MAL loci in natural populations of Saccharomyces cerevisiae and Saccharomyces paradoxus." Genetics 136, no. 3 (1994): 803–12. http://dx.doi.org/10.1093/genetics/136.3.803.

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Abstract In Saccharomyces cerevisiae, the gene functions required to ferment the disaccharide maltose are encoded by the MAL loci. Any one of five highly sequence homologous MAL loci identified in various S. cerevisiae strains (called MAL1, 2, 3, 4 and 6) is sufficient to ferment maltose. Each is a complex of three genes encoding maltose permease, maltase and a transcription activator. This family of loci maps to telomere-linked positions on different chromosomes and most natural strains contain more than one MAL locus. A number of naturally occurring, mutant alleles of MAL1 and MAL3 have been

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28

Braunstein, Marc J., Na Liu, Uwe Klueppelberg, et al. "Differential Effects of Hsp70 Inhibition within the Tumor and Microenvironment in Multiple Myeloma." Blood 108, no. 11 (2006): 5070. http://dx.doi.org/10.1182/blood.v108.11.5070.5070.

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Abstract Multiple myeloma (MM) remains fatal despite prolonged survival by recent advances in treatment, including the use of proteasome inhibitors. It has been proposed that proteasome inhibitors target MM by modulating the NF-κB pathway. Alternatively, proteasome inhibitors may target MM cells because the proteasome helps alleviate the unfolded protein response (UPR) that results from the accumulation of aberrant proteins in the endoplasmic reticulum (ER), which in turn may trigger apoptosis. Indeed, the UPR is induced in neoplastic plasma cells, possibly because of increased immunoglobulin

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29

Page, Jessica, Elisie Kåresdotter, Georgia Destouni, Haozhi Pan, and Zahra Kalantari. "A more complete accounting of greenhouse gas emissions and sequestration in urban landscapes." Anthropocene 34 (October 28, 2022): 100296. https://doi.org/10.5281/zenodo.7261197.

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Understanding interactions between complex human and natural systems involved in urban carbon cycling is important when balancing the dual goals of urban development to accommodate a growing population, while also achieving urban carbon neutrality. This study develops a systems breakdown accounting method to assess the urban carbon cycle. The method facilitates greater understanding of the complex interactions within and between systems involved in this cycle, in order to identify ways in which humans can adapt their interactions to reduce net greenhouse gas emissions from urban

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Pan, Haozhi, Jessica Page, Le Zhang, et al. "Understanding interactions between urban development policies and GHG emissions: A case study in Stockholm Region." Ambio 49/7 (November 20, 2019): 1313–27. https://doi.org/10.5281/zenodo.7261296.

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Human-induced urban growth and sprawl have implications for greenhouse gas (GHG) emissions that may not be included in conventional GHG accounting methods. Improved understanding of this issue requires use of interactive, spatial-explicit social–ecological systems modeling. This paper develops a comprehensive approach to modeling GHG emissions from urban developments, considering Stockholm County, Sweden as a case study. GHG projections to 2040 with a social–ecological system model yield overall greater emissions than simple extrapolations in official climate action planning. The m

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Chen, Yuanying, Vladimir Cvetkovic, and Georgia Destouni. "Scenarios of Nutrient-Related Solute Loading and Transport Fate from Different Land Catchments and Coasts into the Baltic Sea." Water 11/7 (July 9, 2019): 1407. https://doi.org/10.5281/zenodo.7261322.

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This study uses controlled numerical experimentation to comparatively simulate and investigate solute transport and concentration responses and patterns in the Baltic Sea for various solute releases from the land through two different coastal cases. These cases are the Swedish Kalmar County coast and the Polish coast of the Vistula River outlet. For equivalent solute releases, the coastal flow conditions and their interactions with main marine currents determine the local coastal solute spreading, while the overall spreading over the Baltic Sea is similar for the two coastal cases, despite the

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Destouni, Georgia, and Carmen Prieto. "Robust Assessment of Uncertain Freshwater Changes: The Case of Greece with Large Irrigation—and Climate-Driven Runoff Decrease." Water 10/11 (November 13, 2018): 1645. https://doi.org/10.5281/zenodo.7261431.

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We develop a data-driven approach to robustly assess freshwater changes due to climate change and/or human irrigation developments by use of the overarching constraints of catchment water balance. This is applied to and tested in the high-uncertainty case of Greece for five nested catchments of different scales across the country and for freshwater changes from an early period (1930–1949) with small human influences on climate and irrigation to a recent period (1990–2009) with expected greater such influences. The results show more or less equal contributions from climatic decrease

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Vigouroux, Guillaume, Georgia Destouni, Anders Jönsson, and Vladimir Cvetkovic. "A scalable dynamic characterisation approach for water quality management in semi-enclosed seas and archipelagos." Marine Pollution Bulletin 139 (January 8, 2019): 311–27. https://doi.org/10.5281/zenodo.7261459.

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In semi-enclosed seas, eutrophication may affect both the coastal waters and the whole sea. We develop and test a modelling approach that can account for nutrient loads from land as well as for influences and feedbacks on water quality across the scales of a whole semi-enclosed sea and its coastal zones. We test its applicability in the example cases of the Baltic Sea and one of its local archipelagos, the Archipelago Sea. For the Baltic Sea scale, model validation shows good representation of surface water quality dynamics and a generally moderate model performance for deeper w

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Destouni, Georgia, Jacopo Cantoni, and Zahra Kalantari. "Distinguishing active and legacy source contributions to stream water quality: Comparative quantification for chloride and metals." Hydrological Processes 35 (October 28, 2022): 11. https://doi.org/10.5281/zenodo.7261483.

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Hydrochemical constituents in streams may originate from currently active sources at the surface and/or legacy sources from earlier surface inputs, waste deposits and land contamination. Distinction and quantification of these source contributions are needed for improved interpretation of tracer data and effective reduction of waterborne environmental pollutants. This article develops a methodology that recognizes and quantifies some general mechanistic differences in stream concentration and load behavior versus discharge between such source contributions. The methodology is applied to compar

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35

Tanabe, Takuma, Makoto Kawamukai, and Yasuhiro Matsuo. "Glucose limitation and pka1 deletion rescue aberrant mitotic spindle formation induced by Mal3 overexpression in Schizosaccharomyces pombe." Bioscience, Biotechnology, and Biochemistry 84, no. 8 (2020): 1667–80. http://dx.doi.org/10.1080/09168451.2020.1763157.

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36

Browning, Heidi, and David D. Hackney. "The EB1 Homolog Mal3 Stimulates the ATPase of the Kinesin Tea2 by Recruiting It to the Microtubule." Journal of Biological Chemistry 280, no. 13 (2005): 12299–304. http://dx.doi.org/10.1074/jbc.m413620200.

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37

Polakova, Silvia, Zsigmond Benko, Lijuan Zhang, and Juraj Gregan. "Mal3, theSchizosaccharomyces pombehomolog of EB1, is required for karyogamy and for promoting oscillatory nuclear movement during meiosis." Cell Cycle 13, no. 1 (2013): 72–77. http://dx.doi.org/10.4161/cc.26815.

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38

Matsuo, Yuzy, Sebastian P. Maurer, Masashi Yukawa, et al. "An unconventional interaction between Dis1/TOG and Mal3/EB1 in fission yeast promotes the fidelity of chromosome segregation." Journal of Cell Science 129, no. 24 (2016): 4592–606. http://dx.doi.org/10.1242/jcs.197533.

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39

Shen, Ningning, Libo Han, Zixuan Liu, et al. "The Microtubule End Binding Protein Mal3 Is Essential for the Dynamic Assembly of Microtubules during Magnaporthe oryzae Growth and Pathogenesis." International Journal of Molecular Sciences 25, no. 5 (2024): 2672. http://dx.doi.org/10.3390/ijms25052672.

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Cytoskeletal microtubules (MTs) play crucial roles in many aspects of life processes in eukaryotic organisms. They dynamically assemble physiologically important MT arrays under different cell conditions. Currently, aspects of MT assembly underlying the development and pathogenesis of the model plant pathogenic fungus Magnaporthe oryzae (M. oryzae) are unclear. In this study, we characterized the MT plus end binding protein MoMal3 in M. oryzae. We found that knockout of MoMal3 results in defects in hyphal polar growth, appressorium-mediated host penetration and nucleus division. Using high-res

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Al-Bassam, Jawdat, Hwajin Kim, Ignacio Flor-Parra, Neeraj Lal, Hamida Velji, and Fred Chang. "Fission yeast Alp14 is a dose-dependent plus end–tracking microtubule polymerase." Molecular Biology of the Cell 23, no. 15 (2012): 2878–90. http://dx.doi.org/10.1091/mbc.e12-03-0205.

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XMAP215/Dis1 proteins are conserved tubulin-binding TOG-domain proteins that regulate microtubule (MT) plus-end dynamics. Here we show that Alp14, a XMAP215 orthologue in fission yeast, Schizosaccharomyces pombe, has properties of a MT polymerase. In vivo, Alp14 localizes to growing MT plus ends in a manner independent of Mal3 (EB1). alp14-null mutants display short interphase MTs with twofold slower assembly rate and frequent pauses. Alp14 is a homodimer that binds a single tubulin dimer. In vitro, purified Alp14 molecules track growing MT plus ends and accelerate MT assembly threefold. TOG-d

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Chen, Yuanying, Guillaume Vigouroux, Arvid Bring, Vladimir Cvetkovic, and Georgia Destouni. "Dominant Hydro-Climatic Drivers of Water Temperature, Salinity, and Flow Variability for the Large-Scale System of the Baltic Coastal Wetlands." Water 11/3 (March 17, 2019): 552. https://doi.org/10.5281/zenodo.7261329.

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For the large-scale coastal wetland system of the Baltic Sea, this study develops a methodology for investigating if and to what degree the variability and changes in certain hydro-climatic drivers control key coastal–marine physical conditions. The studied physical conditions include: (a) water temperature, (b) water salinity, and (c) flow structures (magnitudes and directions of flows between marine basins and the associated coastal zones and wetlands). We use numerical simulations of three hydro-climatically distinct cases to investigate the variations in hydro-climatic drivers and th

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Mana-Capelli, Sebastian, Janel R. McLean, Chun-Ti Chen, Kathleen L. Gould, and Dannel McCollum. "The kinesin-14 Klp2 is negatively regulated by the SIN for proper spindle elongation and telophase nuclear positioning." Molecular Biology of the Cell 23, no. 23 (2012): 4592–600. http://dx.doi.org/10.1091/mbc.e12-07-0532.

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In Schizosaccharomyces pombe, a late mitotic kinase pathway called the septation initiation network (SIN) triggers cytokinesis. Here we show that the SIN is also involved in regulating anaphase spindle elongation and telophase nuclear positioning via inhibition of Klp2, a minus end–directed kinesin-14. Klp2 is known to localize to microtubules (MTs) and have roles in interphase nuclear positioning, mitotic chromosome alignment, and nuclear migration during karyogamy (nuclear fusion during mating). We observe SIN-dependent disappearance of Klp2 from MTs in anaphase, and we find that this is med

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Tanabe, Takuma, Masayuki Yamaga, Makoto Kawamukai, and Yasuhiro Matsuo. "Mal3 is a multi-copy suppressor of the sensitivity to microtubule-depolymerizing drugs and chromosome mis-segregation in a fission yeast pka1 mutant." PLOS ONE 14, no. 4 (2019): e0214803. http://dx.doi.org/10.1371/journal.pone.0214803.

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Manzoni, Stefano, Giorgos Maneas, Anna Scaini, Basil E. Psiloglou, Georgia Destouni, and Steve W. Lyon. "Understanding coastal wetland conditions and futures by closing their hydrologic balance: the case of the Gialova lagoon, Greece." Hydrology and Earth System Sciences 24/7 (July 15, 2020): 3557–71. https://doi.org/10.5281/zenodo.7261126.

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Coastal wetlands and lagoons are under pressure due to competing demands for freshwater resources and climatic changes, which may increase salinity and cause a loss of ecological functions. These pressures are particularly high in Mediterranean regions with high evaporative demand compared to precipitation. To manage such wetlands and maximize their provision of ecosystem services, their hydrologic balance must be quantified. However, multiple channels, diffuse surface water exchanges, and diverse groundwater pathways complicate the quantification of different water balance components. To over

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Vigouroux, Guillaume, Georgia Destouni, Elina Kari, José M. Beltrán-Abaunza, Petteri Uotila, and Dekui Yuan. "Trend correlations for coastal eutrophication and its main local and whole-sea drivers – Application to the Baltic Sea." Science of The Total Environment 779 (July 20, 2021): 146367. https://doi.org/10.5281/zenodo.7261224.

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Coastal eutrophication is a major environmental issue worldwide. In the Baltic Sea, eutrophication affects both the coastal waters and the open sea. Various policy frameworks aim to hinder its progress but eutrophication-relevant water quality variables, such as chlorophyll-a concentrations, still exhibit opposite temporal trends in various Baltic Sea marine and coastal waters. In this study, we investigate the temporal-trend linkages of measured water quality variables and their various anthropogenic, climatic and hydrospheric drivers over the period 1990–2020 with focus on th

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Vigouroux, Guillaume, Yuanying Chen, Anders Jönsson, Vladimir Cvetkovic, and Georgia Destouni. "Simulation of nutrient management and hydroclimatic effects on coastal water quality and ecological status—The Baltic Himmerfjärden Bay case." Ocean & Coastal Management 198 (September 2, 2020): 105360. https://doi.org/10.5281/zenodo.7261268.

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Coastal eutrophication is a common problem worldwide, with main drivers including land-based freshwater and nutrient discharges, as well as hydroclimatic and open sea conditions. This study investigates the combined effects of different hydroclimatic and eutrophication management scenarios on coastal water quality and ecological status. As a case study we consider and simulate these scenarios for the Himmerfjärden Bay, situated in the semi-enclosed Baltic Sea. Effects on different eutrophication-relevant variables are assessed for several potential land, coast and/or sea-based management

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Katsuki, Miho, and Robert A. Cross. "3P-176 In vitro reconstitution of regulated S. pombe microtubule dynamics : the synergy of S. pombe EB1 family member Mal3 and kinesin-7, Tea2(The 46th Annual Meeting of the Biophysical Society of Japan)." Seibutsu Butsuri 48, supplement (2008): S154. http://dx.doi.org/10.2142/biophys.48.s154_4.

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Charron, M. J., R. A. Dubin, and C. A. Michels. "Structural and functional analysis of the MAL1 locus of Saccharomyces cerevisiae." Molecular and Cellular Biology 6, no. 11 (1986): 3891–99. http://dx.doi.org/10.1128/mcb.6.11.3891-3899.1986.

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We describe the isolation of a 22.6-kilobase fragment of DNA containing the MAL1 locus of Saccharomyces cerevisiae. Our results demonstrate that the MAL1 locus, like the MAL6 locus, is a complex locus containing three genes. These genes were organized similarly to their MAL6 counterparts. We refer to them as MAL11, MAL12, and MAL13 and show that they are functionally homologous to the MAL61 (encoding maltose permease), MAL62 (encoding maltase), and MAL63 (encoding the positive regulator) genes of the MAL6 locus. Transcription from each of the three genes was analyzed in a strain carrying the u

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Charron, M. J., R. A. Dubin, and C. A. Michels. "Structural and functional analysis of the MAL1 locus of Saccharomyces cerevisiae." Molecular and Cellular Biology 6, no. 11 (1986): 3891–99. http://dx.doi.org/10.1128/mcb.6.11.3891.

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Abstract:

We describe the isolation of a 22.6-kilobase fragment of DNA containing the MAL1 locus of Saccharomyces cerevisiae. Our results demonstrate that the MAL1 locus, like the MAL6 locus, is a complex locus containing three genes. These genes were organized similarly to their MAL6 counterparts. We refer to them as MAL11, MAL12, and MAL13 and show that they are functionally homologous to the MAL61 (encoding maltose permease), MAL62 (encoding maltase), and MAL63 (encoding the positive regulator) genes of the MAL6 locus. Transcription from each of the three genes was analyzed in a strain carrying the u

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KODRIĆ-ZAIMOVIĆ, Lejla. "„SMALL CULTURES“ AND „SMALL LANGUAGES“ IN THE ENVIRONMENT OF SOCIAL MEDIA AND PARTICIPATORY CULTURE." Lingua Montenegrina 28, no. 2 (2021): 147–59. https://doi.org/10.46584/lm.v28i2.873.

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Trends of overcoming traditional oppositions „high culture“ / „low culture“, „big culture“ / „small culture“ and the significant expansion of the scope of concept of culture in the direction within which culture means forms of everyday life but also the so-called „popular culture“ have been a way of seeing culture in the recent decades. This is especially intensified with UNES-CO's commitment to overcoming the Eurocentric concept of culture in the direction of its broader, global understanding and relativization in the relation of dominant vs. subordinate cultural groups and forms. In accordan

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