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Dissertations / Theses on the topic 'Malara associati'

Author: Grafiati

Published: 27 February 2023

Last updated: 31 July 2025

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1

Nisar, Samia. "Role of ATP2B4 and human malaria : looking for functional genetic variants associated with malaria." Thesis, Aix-Marseille, 2020. http://theses.univ-amu.fr.lama.univ-amu.fr/200911_NISAR_992dobfs271wcdsgy656twqjfn399ockic_TH.pdf.

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GWAS pour le paludisme grave identifié 30 variantes génétiques situées dans régions non codantes, avec seulement quelques associations répliquées dans des populations indépendantes. Dans cette étude, nous avons cherché à identifier les variantes génétiques potentielles situées dans ces loci et à démontrer leur activité fonctionnelle. Nous avons systématiquement étudié l'effet régulateur des SNP en déséquilibre liaison avec les tagSNPs associés au paludisme sévère dans plusieurs populations. L'annotation et priorisation ont conduit à l'identification d'une région régulatrice contenant 5 SNP ATP

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2

Tétard, Marilou. "Mechanisms associated to hemoglobinopathic protection against plasmodium falciparum malaria." Thesis, Sorbonne Paris Cité, 2018. http://www.theses.fr/2018USPCC257.

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La protection contre le paludisme, conférée par les hémoglobinopathies (HbS et HbC), a été bien définie mais les mécanismes moléculaires et cellulaires sous-jacents restent méconnus. Un des mécanismes proposés, implique une présentation anormale des PfEMP1 à la surface des globules rouges infectés et a été associé à une diminution de l’expression de surface de ces PfEMP1 causant une diminution de l’adhérence des globules rouges parasités (GRp) aux cellules de l’endothélium vasculaire. Dans une étude de cohorte de femmes enceintes au Bénin, nous avons premièrement montré que le génotype HbAC et

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3

Lindh, Jenny. "Identification of bacteria associated with malaria mosquitoes - Their characterisation and potential use." Doctoral thesis, Stockholm : Department of Genetics, Microbiology and Toxicology, Stockholm University, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6685.

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4

Silva, Leandro Gustavo da. "Papel dos receptores do tipo Toll (TLRs) na imunopatogênese da malária associada à gravidez." Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42135/tde-21032012-160144/.

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A malária asociada à gavidez pode gerar complicações para a mãe e para o feto. Receptores do tipo Toll (TLR) TLR2, TLR4 e TLR9, podem reconhecer componentes do Plasmódio. Estes receptores sinalizam via proteína MyD88. Contudo existem poucos dados sobre os TLR na malária placentária. Assim, o objetivo desse trabalho foi estudar o papel dos TLR2, 4, 9 e da MyD88 na malária placentária. Dentre fêmeas C57BL/6, TLR2-/-, TLR9-/- e MyD88-/-, a linhagem MyD88-/- apresentou maiores níveis de parasitemia, sobrevivência e cuidado parental, e ainda placentas de fêmeas MyD88-/- infectadas, ao contrario das

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5

Loucoubar, Cheikh. "Statistical genetic analysis of infectious disease (malaria) phenotypes from a longitudinal study in a population with significant familial relationships." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00685104.

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Long term longitudinal surveys have the advantage to enable several sampling of the studied phenomena and then, with the repeated measures obtained, find a confirmed tendency. However, these long term surveys generate large epidemiological datasets including more sources of noise than normal datasets (e.g. one single measure per observation unit) and potential correlation in the measured values. Here, we studied data from a long-term epidemiological and genetic survey of malaria disease in two family-based cohorts in Senegal, followed for 19 years (1990-2008) in Dielmo and for 16 years (1993-2

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6

Redmond, Seth. "Population structure and genome-wide association in the malaria vectors Anopheles gambiae and Anopheles coluzzii." Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066085/document.

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Malgré le succès des insecticides pour le contrôle du paludisme, la transmission continue dans la plupart des pays d’Afrique sub-saharienne. La recherche pour de nouveaux moyens de contrôle (plus spécialement la modification génétique des populations vecteurs), ou l'utilisation plus efficace des contrôles actuels, vont nécessiter une recherche sur les structures de populations de moustiques et les processus d’immunisation qui importent pour la transmission du Plasmodium chez les moustiques sauvages. Par ailleurs, l’utilisation des techniques d’association génomique ‘GWAS’ est basée sur un réel

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7

Redmond, Seth. "Population structure and genome-wide association in the malaria vectors Anopheles gambiae and Anopheles coluzzii." Electronic Thesis or Diss., Paris 6, 2015. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2015PA066085.pdf.

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Malgré le succès des insecticides pour le contrôle du paludisme, la transmission continue dans la plupart des pays d’Afrique sub-saharienne. La recherche pour de nouveaux moyens de contrôle (plus spécialement la modification génétique des populations vecteurs), ou l'utilisation plus efficace des contrôles actuels, vont nécessiter une recherche sur les structures de populations de moustiques et les processus d’immunisation qui importent pour la transmission du Plasmodium chez les moustiques sauvages. Par ailleurs, l’utilisation des techniques d’association génomique ‘GWAS’ est basée sur un réel

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8

Thomas, Phaedra J. "A Forward Genetic Screen Identifies Factors Associated with Fever Pathogenesis in Plasmodium falciparum." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5785.

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Infectious diseases that spread from person-to-person and continent-to-continent are a cause for concern for any health entity. One such disease is malaria, a mosquito-borne infection instigated by the protozoan parasite, Plasmodium falciparum. Hundreds of millions of people are affected annually and it is responsible for nearly 1 million deaths. It is the most fatal species causing malaria and proliferates in human red blood cells with a life cycle occurring every 48 hours. At this time, the parasite’s late stage form or schizont bursts from the erythrocyte releasing immune-inducing particles

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9

Prapansilp, Panote. "Molecular pathological investigation of the pathophysiology of fatal malaria." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:e966a2f2-a37d-4586-b09e-2bb616e5dce2.

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Malaria remains one of the world's major health problems, especially in developing countries. A better understanding of the pathology and pathophysiology of severe malaria is key to develop new treatments. Different approaches have been used in malaria research including the in vitro co-culture models with endothelial cells and both murine and simian animal models. However these are open to controversy due to disagreement on their representativeness of human disease. Using human post-mortem tissue in malaria research is another important approach but is practically challenging, limiting the av

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10

Fernandez-Reyes, Delmiro. "Association of polymorphisms in intercellular adhesion molecule-1 (ICAM-1) with severe disease in Plasmodium falciparum malaria." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299524.

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11

MACHADO, Patrícia Isabel Pires. "Pyruvate kinase and glucose-6-phosphate dehydrogenase deficies and their association with malaria - population genetics and proteomic studies." Doctoral thesis, Instituto de Higiene e Medicina Tropical, 2013. http://hdl.handle.net/10362/11346.

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A malária é reconhecida como uma das principais forças selectivas a actuar na história recente no genoma humano. Inúmeros polimorfismos genéticos têm sido descritos como protectores contra a gravidade da malária, como o alelo HbS (designado de traço falciforme) e o alelo G6PD A- (associado à deficiência de G6PD). Mais recentemente, também a deficiência de PK foi associada com a protecção contra a malária. Evidências desta associação foram obtidas em estudos com modelos de roedor e estudos in vitro utilizando GV humanos deficientes em PK. Até à data, não foram obtidos dados em populações humana

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12

Hardee, Angelica. "Association of Malaria Control Methods and Healthcare Access among Pregnant Women in the Democratic Republic of the Congo." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1490350707310335.

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13

Fry, Andrew E. "Genome mapping of malaria resistance genes : the host ligands of PfEMP1." Thesis, University of Oxford, 2009. http://ora.ox.ac.uk/objects/uuid:df1ffe4b-ba67-4fc6-9024-b278b887d4f9.

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Erythrocytes infected by mature forms of the Plasmodium falciparum parasite adhere to other components of the vascular space, a behavior considered critical to the pathogenesis of severe malaria. Adhesion is mediated by the P. falciparum erythrocyte membrane protein 1 (PfEMP1), a highly variant antigen expressed by the parasite and subject to switching during the course of an infection. The host ligands of PfEMP1 include CD36, ICAM-1 and the ABO antigens. By employing a series of population- and family-based association studies from multiple African populations, we examined whether variation i

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14

Baaklini, Sabrina. "Compréhension de la résistance humaine au paludisme : des études génétiques aux approches fonctionnelles." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0384/document.

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La sévérité du paludisme est influencée par des interactions complexes entre de nombreux facteurs dont la génétique de l’hôte. Plusieurs études de liaison génétique menées dans différentes ethnies africaines ont montré une liaison entre le locus 6p21 et le paludisme simple. De plus, différents variants au sein des gènes TNF et NCR3, retrouvés dans ce locus, ont été indépendamment associés à ce phénotype au Burkina Faso.Ainsi, nous nous sommes tout d’abord intéressés aux polymorphismes du TNF. Nos résultats montrent que les variants TNF-308, TNF-244, et TNF-238 sont associés à la parasitémie ma

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15

Griffiths, Michael J. "Integrated approach to identifying genes critical in the response to malaria using gene expression profiling and disease association analyses." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491498.

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16

Ventura, Marcielle Teixeira. "Emulsões pediátricas de artesunato associado com cloridrato de mefloquina no tratamento da malária: desenvolvimento e estudo de estabilidade." Niterói, 2017. https://app.uff.br/riuff/handle/1/3350.

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Submitted by Biblioteca da Faculdade de Farmácia (bff@ndc.uff.br) on 2017-04-17T18:14:43Z No. of bitstreams: 1 Ventura, Marcielle Teixeira [Dissertação, 2014].pdf: 1365184 bytes, checksum: 3d4c74cf63404132c709dcde62ba0960 (MD5)<br>Made available in DSpace on 2017-04-17T18:14:43Z (GMT). No. of bitstreams: 1 Ventura, Marcielle Teixeira [Dissertação, 2014].pdf: 1365184 bytes, checksum: 3d4c74cf63404132c709dcde62ba0960 (MD5)<br>A Malária é uma doença tropical muito importante em saúde pública devido às altas taxas de morbidade e mortalidade no mundo. Essa doença ocorre principalmente nas regi

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17

Cederlund, Julia. "Association between maternal level of education and the treatment with antimalarial drugs in children under the age of 5 in Nigeria : A cross-sectional study." Thesis, Uppsala universitet, Internationell mödra- och barnhälsovård (IMCH), 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-414328.

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Background Malaria is a major threat to global public health, with adverse health effects. Nigeria alone accounts for 25% of the global burden of malaria. Children are especially vulnerable to malaria, and if the disease is not treated it could have fatal consequences. Mothers have an important role in ensuring that adequate and timely treatment is given to the child. Aim The aim of this study was to investigate whether there was an association between maternal level of education and the treatment with antimalarial drugs in malaria positive children under-5 in Nigeria. Methods This study was a

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18

Neumayr, Andreas Vipa Thanachartwet. "Malarial acute renal failure at Mae Sot general hospital, Thailand : outcome and associated risk factors for death and dialysis /." Abstract, 2008. http://mulinet3.li.mahidol.ac.th/thesis/2551/cd414/5038610.pdf.

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Thematic Paper (M.C.T.M. (Clinical Tropical Medicine))--Mahidol University, 2008.<br>LICL has E-Thesis 0038 ; please contact computer services. LIRV has E-Thesis 0038 ; please contact circulation services.

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19

Sikora, Martin. "Evolutionary genetics of malaria: genetic susceptibility and natural selection." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/7220.

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Una de les forces selectives més fortes que han afectat a les poblacions humanes en la història més recent és el paràsit de la malària: Plasmodium falciparum, que és la causa de varis exemples d'adaptació induïda per patògens en els éssers humans. Una forma especial de malària és l'associada a l'embaràs, que es caracteritza per l'acumulació d'eritròcits infectats en la placenta, i que pot arribar a causar fins a 200.000 morts maternoinfantils cada any. L'objectiu d'aquest treball és descriure com aquesta forma peculiar de malària ha afectat la variació genètica humana. Amb aquesta finalitat, h

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20

Ernst, Kacey C., Steven Erly, Charity Adusei, et al. "Reported bed net ownership and use in social contacts is associated with uptake of bed nets for malaria prevention in pregnant women in Ghana." BIOMED CENTRAL LTD, 2017. http://hdl.handle.net/10150/622728.

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Background: Despite progress made in the last decades, malaria persists as a pressing health issue in sub-Saharan Africa. Pregnant women are particularly vulnerable to infection and serious health outcomes for themselves and their unborn child. Risk can be mitigated through appropriate use of control measures such as insecticide-treated bed nets. Although social networks can influence uptake of preventive strategies, the role of social influence on bed net ownership has not been explored. During an evaluation of a bed net distribution programme, the influence of non-health care advisors on own

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21

Brisebarre, Audrey. "Recherche de facteurs génétiques impliqués dans la résistance au paludisme et au sepsis : études pangénomiques de liaison génétique et d'association, intégration des résultats d' association aux réseaux d' intéractions protéine-protéine." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4072.

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Le paludisme et le sepsis sont des maladies infectieuses très répandues causant plusieurs centaines de milliers de morts tous les ans. Elles sont toutes deux multifactorielles. Les devenirs de ces infections sont influencés par des facteurs environnementaux, par des facteurs sociaux-économiques, politiques et comportementaux mais aussi par des variables dépendant du patient comme son âge. De nombreux arguments existent en faveur d'un contrôle génétique de la résistance au paludisme et au sepsis. Ces deux maladies sont considérées comme proches par les spécialistes car leur physiopathologie est

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22

Frank, Clemens [Verfasser]. "Spatial heterogeneity of malaria in Ghana : a cross-sectional study of the association between urbanicity and the acquisition of immunity / Clemens Frank." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1119803411/34.

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23

Kern, Selina Melanie [Verfasser], and Gabriele [Gutachter] Pradel. "Functional characterization of splicing-associated kinases in the blood stages of the malaria parasite Plasmodium falciparum / Selina Melanie Kern. Gutachter: Gabriele Pradel." Würzburg : Universität Würzburg, 2015. http://d-nb.info/1111508720/34.

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24

Pereira, Marcelo Luís Monteiro. "O papel da heme oxigenase 1 na síndrome do desconforto respiratório agudo associada à malária." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/42/42133/tde-11112016-154538/.

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A malária é uma doença causada pelo parasita do gênero Plasmodium e que foi responsável por cerca de 440.000 mortes em 2015. A síndrome do desconforto respiratório agudo (SDRA) é uma das principais complicações clínicas da malária. O modelo murino DBA/2 reproduz os sinais clínicos da SDRA observados em humanos, quando infectado com o Plasmodium berghei ANKA. Além disso, altos níveis da enzima heme oxigenase 1 (HO-1) foram observados em casos de malária cerebral e em SDRA em humanos. Os nossos dados indicam que os níveis da HO-1 estão aumentados em camundongos que desenvolvem SDRA associada à m

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25

Kamaranzi, Bakunda Kaakaabaale. "Factors associated with late presentation of children under five and pregnant women with malaria for treatment at health units in Bungokho Health Sub District." Thesis, University of the Western Cape, 2010. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9025_1363357146.

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<p>Background: Malaria is the leading cause of death of Uganda&rsquo<br>s children under 5 years of age and the number-one cause of illness in adults in Uganda. The success of malaria treatment strategies is closely linked to the behavior of patients and caretakers of young children. In the case of malaria this includes accessing appropriate treatment for&nbsp<br>suspected malaria in time. In Bungokho Sub County, in spite of the efforts by district health workers and the Ministry of Health to implement the malaria control, prevention and treatment strategies, pregnant women and caretakers of c

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26

Dgedge, Martinho do Carmo. "Implementation of an insecticide treated bednet programme for malaria prevention through the primary health care system in Mozambique : socioeconomic factors associated with sustainability and equity." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2000. http://researchonline.lshtm.ac.uk/682299/.

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Malaria is the principal cause of morbidity and mortality in Mozambique, accounting for more than 40% of the attendance in the public health clinics. Insecticide-treated bednets; (ITNs) have proved to be a cost-effective means of preventing of malaria. Most previous ITN projects have been implemented in pilots or trials and with substantial financial, human and technical resources. Presently however, in many African countries services can no longer be provided "free" (at no charge to users). There is still a lack of knowledge of how financially sustainable and equitable a cost-sharing ITN prog

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27

Strauß, Christina Verfasser], and Julia [Akademischer Betreuer] [Kehr. "Genetic fine mapping and functional analysis of a chromosomal region within ATP2B4 associated with resistance against severe malaria in humans / Christina Strauß ; Betreuer: Julia Kehr." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://nbn-resolving.de/urn:nbn:de:gbv:18-86637.

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Strauß, Christina [Verfasser], and Julia [Akademischer Betreuer] Kehr. "Genetic fine mapping and functional analysis of a chromosomal region within ATP2B4 associated with resistance against severe malaria in humans / Christina Strauß ; Betreuer: Julia Kehr." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2020. http://d-nb.info/1209676133/34.

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29

Dwivedi, Ankit. "Functional analysis of genomic variations associated with emerging artemisinin resistant P. falciparum parasite populations and human infecting piroplasmida B. microti." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT073/document.

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Le programme d’élimination du paludisme de l’OMS est menacé par l’émergence etla propagation potentielle de parasites de l’espèce Plasmodium falciparum résistants à l’artémisinine. Récemment il a été montré que (a) des SNPs dans une région du chromosome 13 subissaient une forte sélection positive récente au Cambodge,(b) plusieurs sous-populations de parasites de P. falciparum résistants et sensibles à l’artémisinine étaient présentes au Cambodge, (c) des mutations dans le domaine Kelch du gène k13 sont des déterminants majeurs de la résistance à l’artémisinine dans la population parasitaire ca

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LANDES, PAUL. "Syndrome de gougerot-sjogren, cancer bronchopulmonaire a petites cellules, syndrome de lambert-eaton chez un meme malade : cette association est-elle fortuite ?" Toulouse 3, 1988. http://www.theses.fr/1988TOU31221.

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Swan, Paul Lombard. "Synthesis of mixed ligand, water soluble square planar platinum (II) complexes and an investigation of their association with haematin and potential to inhibit the formation of synthetic malaria pigment." Master's thesis, University of Cape Town, 2002. http://hdl.handle.net/11427/9782.

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Includes bibliography.<br>To establish their potential as a template for novel anti-malarial drugs, a series of planinum (II) complexes were synthesised, their association with haematin determined in 40 aqueous DMSO, pH 7.4 at 25°C and their ability to inhibit the formation of β-haematin (synthetic malaria pigment) was investigated. The compounds synthesised and investigated contained a platinum (II) ion coordinated to acylthiourea and diimine ligands. The diimines used included both substituted and unsubstituted 2,2’-bipyridines and 1,10-phenanthrolines. 2-phenyl pyridine was also utilised as

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Adukpo, Selorme [Verfasser], and Peter [Akademischer Betreuer] Kremsner. "Distribution of Knop blood group antigens and association of Triggering receptor expressed on myeloid cells 1 (TREM-1) gene variants in Ghanaian children with malaria / Selorme Adukpo ; Betreuer: Peter Kremsner." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1165579014/34.

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Adukpo, Selorme Verfasser], and Peter [Akademischer Betreuer] [Kremsner. "Distribution of Knop blood group antigens and association of Triggering receptor expressed on myeloid cells 1 (TREM-1) gene variants in Ghanaian children with malaria / Selorme Adukpo ; Betreuer: Peter Kremsner." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1165579014/34.

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Milet, Jacqueline. "Étude de la composante génétique de la variabilité des infections palustres simples : Approche génome entier dans deux cohortes de jeunes enfants au Bénin First Genome-Wide Association Study of Non-Severe Malaria in Two Birth Cohorts in Benin Mixed logistic regression in Genome-Wide Association Studies." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASR013.

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Malgré les moyens importants de prévention et de lutte mis en place ces dernières années, le paludisme reste dévastateur avec près d’un demi-million de décès par an (405 000 en 2018, d'après le dernier rapport de l'OMS). Le rôle clé joué par les facteurs génétiques de l’hôte dans la susceptibilité et la sévérité de la maladie est admis aujourd'hui. Cependant, les bases moléculaires de la sensibilité/résistance au paludisme restent encore mal connues. Ces dix dernières années, les efforts de recherches pour l’identification de gènes impliqués dans la sensibilité au paludisme à P. falciparum se

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Nguyen, Thy Ngoc. "Prédisposition génétique au paludisme à Plasmodium falciparum : études d'association et analyses fonctionnelles de variants génétiques candidats situés dans des régions liées génétiquement au paludisme." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4116.

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Dans cette thèse, nous avons étudié l'influence de plusieurs variants génétiques situés dans les régions chromosomiques 5q31-q33, 6p21, et 17p12, pour lesquelles une liaison génétique avec des phénotypes de paludisme a été montrée.Les gènes NCR3 et TNF, qui sont situés dans la région chromosomique 6p21, ont été associés au paludisme dans une population vivant au Burkina Faso. Nous avons répliqué ces études dans une population congolaise afin deconfirmer les associations des polymorphismes avec les accès palustres simples et la parasitémie symptomatique. Nos résultats montrent que le polymorphi

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Chauvet, Margaux. "Étude de la modulation, par l'hémoglobine S, de la présentation des antigènes plasmodiaux à la surface du globule rouge infecté par Plasmodium falciparum, et de la réponse immunitaire contre le paludisme Impact of hemoglobin S trait on cell surface antibody recognition of Plasmodium falciparum infected erythrocytes in pregnancy-associated malaria." Thesis, Sorbonne Paris Cité, 2019. http://www.theses.fr/2019USPCB037.

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Le paludisme est une maladie tropicale résultant de l'infection par le parasite Plasmodium falciparum transmis par piqûre de moustique. Les symptômes du paludisme résultent du développement de P. falciparum dans les globules rouges (GR). Depuis des siècles, le paludisme a exercé des pressions sur le génome humain, sélectionnant des mutations conférant une protection contre les formes sévères de la maladie. C'est le cas de la mutation du gène de l'hémoglobine (HbA), composant principal des GRs. La forme mutée du gène produit une hémoglobine anormale (HbS). Contrairement à la drépanocytose (HbSS

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Manirakiza, Alexandre. "Utilisation du test de diagnostic rapide(paracheck-pf®) en consultation prénatale dans le cadre du traitement antipaludique à Bangui, République Centrafricaine." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5040/document.

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Entre juin et septembre 2009, nous avons réalisé une étude transversale pour évaluer l'état de la prise en charge du paludisme chez la femme enceinte à Bangui. Les résultats de cette évaluation ont montré que dans les services de consultation prénatale (CPN) de Bangui, 28,8% des femmes enceintes reçoivent à titre curatif au moins une prescription de médicament antipaludique pendant leur grossesse. La quinine et les combinaisons à base d'artémisinine, antipaludiques compatibles avec la grossesse, sont prescrites dans des proportions de 56,7% et 26,8% respectivement. Par contre, la confirmation

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Hliscs, Marion. "Functional Characterization of Actin Sequestering Proteins in Plasmodium berghei." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16452.

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Plasmodien spp. sind obligat intrazellulär lebende Parasiten, welche einen evolutionär konservierten aktinabhängigen molekularen Motor für die Fortbewegung und den Wirtszellein- und -austritt nutzen. In dieser Arbeit werden die Aktinregulatoren Adenylyl- Zyklase- assoziierte Protein (C-CAP), Profilin sowie die Aktin depolymerizierenden Faktoren 1 und 2 (ADF1, ADF2) in Plasmodium berghei charakterisiert. Die Geninaktivierung von C-CAP besitzt keinen Einfluss auf die Entwicklung von pathogenen Blutstadien. C-cap(-) Ookineten bewegen sich jedoch deutlich langsamer, sind aber in der Lage den inver

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"Emerging Drug Resistance of Plasmodium sp Associate with Misdiagnosis of Malaria." Tulane University, 2014.

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Dennis, Adelaide Sandra Mild. "PfATP4 and the biochemical signature of PfATP4-associated compounds." Phd thesis, 2018. http://hdl.handle.net/1885/149540.

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In 2016 more than 200 million cases of malaria were reported and nearly 500 000 people died from the disease. Although there are antimalarial drugs available, the most virulent species of the disease-causing parasite, Plasmodium falciparum, has evolved some level of resistance to many of them. A global effort to accelerate antimalarial drug discovery has led to the finding that one particular parasite protein, the P-type ATPase PfATP4, appears to be the target of a number of potent novel antimalarial compounds. Two of these ‘PfATP4-associated compound

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Nkoka, Owen, and Owen Nkoka. "Assessment of factors associated with use of malaria interventions among Malawian women." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/k6f793.

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Stradi, Melanie. "Genetic and biochemical characterization of the cytochrome P450, CYP6P9, associated with pyrethroid resistance in the African malaria vector Anopheles funestus." Thesis, 2012. http://hdl.handle.net/10539/11083.

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Anopheles funestus Giles is a major vector of malaria in Africa and pyrethroid resistance observed in this species has disrupted malaria control in southern Africa. Metabolic detoxification, based on the overproduction of cytochrome P450s, specifically CYP6P9 and CYP6P13, was identified as the principal resistance mechanism in both field and laboratory populations. This project aimed to characterize this resistance mechanism further, both on a molecular as well as a biochemical level. Biochemical analysis on total P450 activity levels revealed a 25.5-fold increase in the resistant strain compa

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Obala, Andrew Ambogo. "Malaria vector populations associated with the agricultural development at Mamfene, Northern KwaZulu-Natal, South Africa." Thesis, 1995. http://hdl.handle.net/10413/10331.

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The irrigation farming methods on the Makhathini Flats are thought to be responsible for recent increase in malaria cases in the Mamfene area of northern KwaZulu-Natal despite ongoing malaria control activities. Their coincidence with the period of intensive fanning is an interesting one. This study was therefore carried out to determine the relationship between larval habitats and adult mosquito population in malaria transmission using Geographic Information System (GIS). Four types of breeding sites were utilised by malaria vectors in Mamfene, viz; types 1, II, III and IV. Habitat type I was

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Mbago, Thomas. "Factors associated with utilization of insecticide treated nets among pregnant women in northern regions of Namibia." Thesis, 2014. http://hdl.handle.net/10539/15422.

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A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, in partial fulfilment of the requirements for the degree of Master of Science in Epidemiology and Biostatistics<br>Background: Malaria causes an overwhelmingly large number of cases and deaths around the globe every year, with over 90% of deaths occurring in sub-Saharan Africa. Namibia is among the sub Saharan countries that have malaria as a major public health problem, affecting most pregnant women and children in the northern regions. Insecticide treated net (ITN) distribution has b

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Chalwe, Victor F. "Factors associated with mortality from childhood malaria in Navrongo DSS Site, Ghana, 1995-2000." Thesis, 2008. http://hdl.handle.net/10539/4821.

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ABSTRACT: Background: Malaria is endemic throughout Ghana and continues to be a major public health concern especially among pregnant women and children under the age of five. The Ministry of Health (MoH) estimates that over the past ten years, there have been 2-3 million cases of malaria each year, representing 40 percent of outpatient cases, while severe malaria accounts for 33-36 percent of in-patients. Malaria also accounts for 25 percent of the deaths in children under the age of five (GHS, 2001). Correct identification of risk factors could focus interventions at reducing malaria

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Duarte, Lurdes da Glória Rodrigues. "Unraveling maternal and fetal genetic factors protecting from Pregnancy Associated Malaria in the mouse." Doctoral thesis, 2013. http://hdl.handle.net/10362/14237.

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Malaria is one of the most devastating diseases in the world. In Plasmodium endemic regions, pregnant women are among the most vulnerable groups. Pregnancy Associated Malaria (PAM) threatens both maternal and foetal lives. Despite differences between human and mouse placentas PAM mouse models recapitulate key pathological features of human PAM. Here we describe new PAM models of mid gestation infection in the C57BL/6 mouse.(...)

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Dadi, Berhanu Berga. "Modeling malaria cases associated with environmental risk factors in Ethiopia using geographically weighted regression." Master's thesis, 2020. http://hdl.handle.net/10362/95138.

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Dissertation submitted in partial fulfilment of the requirements for the degree of Master of Science in Geospatial Technologies<br>In Ethiopia, still, malaria is killing and affecting a lot of people of any age group somewhere in the country at any time. However, due to limited research, little is known about the spatial patterns and correlated risk factors on the wards scale. In this research, we explored spatial patterns and evaluated related potential environmental risk factors in the distribution of malaria cases in Ethiopia in 2015 and 2016. Hot Spot Analysis (Getis-Ord Gi* statistic) was

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De, Ridder Jaco. "In Silico analysis of malaria parasite databanks for specific genes and motifs associated with immune evasion." Diss., 2001. http://hdl.handle.net/2263/27675.

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In Silica analysis of available biological data is a powerful tool for not only the identification of new genes, but also to study evolutionary relationships and regulatory mechanisms. In this study, a number of bioinformatic tools and techniques were applied on the available sequence data of the malaria parasite, Plasmodium falciparum. In Silica techniques were used for the identification of a genomic sequence tag (GST) matching the facilitated glucose transporter family as assessed by BLAST. The open reading frame encoding the fUll-length glucose transporter gene was subsequently assembled f

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Kern, Selina Melanie. "Functional characterization of splicing-associated kinases in the blood stages of the malaria parasite Plasmodium falciparum." Doctoral thesis, 2014. https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-115219.

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Besides HIV and tuberculosis, malaria still is one of the most devastating infectious diseases especially in developing countries, with Plasmodium falciparum being responsible for the frequently lethal form of malaria tropica. It is a major cause of mortality as well as morbidity, whereby pregnant women and children under the age of five years are most severely affected. Rapidly emerging drug resistances and the lack of an effective and safe vaccine hamper the combat against malaria by chemical and pharmacological regimens, and moreover the poor socio-economic and healthcare conditions in mala

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"Determinants of the spatial and temporal distribution of malaria in zambia and association with vector control." Tulane University, 2012.

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