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Dissertations / Theses on the topic 'Malaria disease'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Павличева, Світлана Володимирівна, Светлана Владимировна Павлычева, Svitlana Volodymyrivna Pavlycheva, and O. Adeyemi. "Malaria: a reemerging disease in Africa." Thesis, Видавництво СумДУ, 2011. http://essuir.sumdu.edu.ua/handle/123456789/15942.

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2

Peery, Ashley Nicole. "Chromosomal Evolution of Malaria Vectors." Diss., Virginia Tech, 2016. http://hdl.handle.net/10919/71698.

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International malaria control initiatives such as the Roll Back Malaria Initiative (RBM) and the Medicines for Malaria Venture (MMV) mobilize resources and spur research aimed at vector control as well as the treatment and eventual eradication of the disease. These efforts have managed to reduce incidence of malaria by an estimated 37% worldwide since 2000. However, despite the promising success of control efforts such as these, the World Health Organization reports a staggering 438,000 deaths from malaria in 2015. The continuing high death toll of malaria as well as emerging insecticide and a

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3

Harris, Philippa Kate. "Functional analysis of PfSUB2 : a malaria merozoite serine disease." Thesis, University College London (University of London), 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.430024.

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4

Douglas, Alexander D. "Developing novel blood-stage malaria vaccines." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:7ca728f5-6b5e-4f59-ae4b-dd81c8d9e2e8.

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Natural exposure to Plasmodium falciparum’s asexual blood-stage results in protection against severe disease, but no vaccine using the widely-studied blood-stage antigens apical membrane antigen 1 (AMA1) or merozoite surface protein 1 (MSP1) has proven convincingly protective in clinical trials. Challenges include antigenic polymorphism, the apparent requirement for exceptionally high antibody concentrations for protection, and clinical-grade production of conformationally-accurate recombinant protein antigens followed by formulation with a human-compatible adjuvant. This thesis describes the

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5

Mideo, Nicole. "Integrating theory and experimentation in the study of malaria." Thesis, Kingston, Ont. : [s.n.], 2009. http://hdl.handle.net/1974/5093.

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6

Howard, Natasha Jayne. "Malaria : surveillance of a travel related disease in South Australia /." Title page, contents and abstract only, 2002. http://web4.library.adelaide.edu.au/theses/09HS/09hsh8480.pdf.

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7

McQuilkin, Patricia A. "Characterization of Severe Malaria in Liberian Children 5 Years Old and Younger." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/896.

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Malaria continues to be a challenging problem in the developing world, and the burden of this life threatening disease continues to be borne by young children living in Sub Saharan Africa. One of the biggest challenges to the prevention and control of this problem lies in accurately diagnosing malaria, and distinguishing it from the many other febrile illnesses which present in children in this age group. Liberia is a West African country with a high burden of malaria. Very little is known about the presentation of severe malaria in children aged 5 years old and younger in Liberia. We undertoo

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McQuilkin, Patricia A. "Characterization of Severe Malaria in Liberian Children 5 Years Old and Younger." eScholarship@UMMS, 2005. http://escholarship.umassmed.edu/gsbs_diss/896.

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Malaria continues to be a challenging problem in the developing world, and the burden of this life threatening disease continues to be borne by young children living in Sub Saharan Africa. One of the biggest challenges to the prevention and control of this problem lies in accurately diagnosing malaria, and distinguishing it from the many other febrile illnesses which present in children in this age group. Liberia is a West African country with a high burden of malaria. Very little is known about the presentation of severe malaria in children aged 5 years old and younger in Liberia. We undertoo

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9

Coleman, Emma Elizabeth. "Individual variation in the TNF response to malaria." Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337559.

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10

Bolad, Ahmed Kamal. "Antibody responses in Plasmodium falciparum malaria and their relation to protection against the disease." Doctoral thesis, Stockholm : Wenner-Grens institut, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-37.

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11

Appiah, Simon K. "Space-time statistical analysis of malaria morbidity incidence cases in Ghana: A geostatistical modelling approach." Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2014. https://ro.ecu.edu.au/theses/1398.

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Malaria is one of the most prevalent and devastating health problems worldwide. It is a highly endemic disease in Ghana, which poses a major challenge to both the public health and socio-economic development of the country. Major factors accounting for this situation include variability in environmental conditions and lack of prevention services coupled with host of other socio-economic factors. Ghana’s National Malaria Control Programme (NMCP) risk assessment measures have been largely based on household surveys which provided inadequate data for accurate prediction of new incidence cases cou

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12

Whitehead, Mitchell E. "Malaria an investigation into the view of disease in the classical world /." Tallahassee, Fla. : Florida State University, 2010. http://purl.fcla.edu/fsu/lib/digcoll/undergraduate/honors-theses/2181913.

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Thesis (Honors paper)--Florida State University, 2010.<br>Advisor: Dr. Svetla Slaveva-Griffin, Florida State University, College of Arts and Sciences, Dept. of Classics. Includes bibliographical references.

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13

Chipeta, Michael Give. "Geostatistical design and analysis for estimating local variations in malaria disease burden." Thesis, Lancaster University, 2016. http://eprints.lancs.ac.uk/84366/.

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Geostatistical design and analysis methods are increasingly used in disease mapping, particularly in resource-limited settings where uniformly precise mapping may be unrealistically costly and the priority is often to identify critical areas where interventions can have the most health impact. In this thesis, which is based on four papers, we address the problem of geostatistical sampling design. In the first paper, we consider the problem of sampling design for efficient spatial prediction taking account of uncertain covariance structure, in the context of nonadaptive designs. We propose two

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14

Howard, Sally Claire. "Statistical estimation of epidemiological parameters relating to infectious disease." Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365804.

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Glynn, Judith Rebecca. "Studies on the influence of infecting dose on the severity of disease." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.245493.

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16

Farouk, Salah Eldin. "T cell and antibody responses in Plasmodium falciparum malaria and their relation to disease susceptibility." Doctoral thesis, Stockholm : Wenner-Grens institut för experimentell biologi, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-320.

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17

Kapulu, Melissa Chola. "Pre-clinical development of viral vectored transmission-blocking malaria vaccines." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:a5610025-28e1-433f-9487-aaa1f6d641a0.

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Malaria transmission-blocking vaccine candidate antigens have been developed to induce antibodies using different delivery systems, mainly protein-in-adjuvant formulations, independently in various laboratories giving varied transmission-blocking activity (TBA). However, only one candidate antigen has been tested in clinical trials. In order to advance the most efficacious target(s) for possible clinical development, a rank order of the leading antigens based on TBA in a head-to-head comparison using a single delivery platform was made. Candidate antigens, AnAPN1, PfsHAP2, Pfs230-C, Pfs25, and

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18

Alkaitis, Matthew S. "Biochemical determinants of nitric oxide synthesis in severe malaria." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:dde50b9c-fea1-432a-8c5f-35e97e641061.

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Inhibition of nitric oxide (NO) signalling may contribute to the pathogenesis of severe malaria. This thesis examines the impact of Plasmodium infection on three key determinants of nitric oxide synthase (NOS) biochemistry: substrate availability, substrate/inhibitor homeostasis and cofactor availability. Arginine, the NOS substrate, is depleted in human patients with severe Plasmodium falciparum malaria and mice infected with P. berghei ANKA. Using heavy isotope tracer infusions to quantify arginine metabolism in infected mice, we found no evidence of increased catabolism by the enzyme argina

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Rutta, Acleus Stanislaus Malinzi Sansanee Chaiyaroj. "Cytokine response and genetic regulation in children and adults with cerebral malaria disease /." Abstract, 1999. http://mulinet3.li.mahidol.ac.th/thesis/2542/42E-AcleusS.pdf.

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Daly, Benjamin. "Avian malaria in the montane tropics." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:70284964-36b6-4135-98d4-4ec8d22c8b45.

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Understanding the unequal distribution of life on earth is a fundamental goal of ecology and evolutionary biology. Past efforts to explain large-scale patterns in diversity have tended to focus on two broad classes of explanation, one invoking the importance of abiotic factors (i.e. climate and vegetation) and the other biotic (i.e. competition); but neither has proven entirely adequate. Parasites are a major but poorly understood component of life that may offer some answers. Yet despite widespread theoretical support and some empirical evidence, the role of parasites in explaining patterns i

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21

Kyriacou, Helen M. "Var gene transcription and clinical disease manifestation in African P. falciparum malaria field isolates." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/2583.

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The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variant surface antigens, encoded by the var gene family, play a crucial role in malaria pathogenesis through mediating immunomodulation and host cell adhesion. Var genes can be sub-grouped according to genetic or functional features. This thesis examined var gene transcription of conserved groups of var genes in the context of clinical malaria disease manifestation in African field isolates. Analysis of var gene transcription in 26 P. falciparum field isolates from Malian children revealed that field isolates from children with

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22

Marbiah, Nuahn Tomanh. "Control of disease due to perennially transmitted malaria in children of rural Sierra Leone." Thesis, London School of Hygiene and Tropical Medicine (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244618.

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23

Dlamini, Sabelo Vusi. "Malaria in Swaziland : disease incidence and prevalence of molecular markers of antimalarial drug resistance." Thesis, London School of Hygiene and Tropical Medicine (University of London), 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.536875.

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24

Hobbs, Henriëtte Renée. "Preparation and evaluation of polymer microspheres for enhanced lateral flow immunoassay: the case study for malaria." Thesis, University of Cape Town, 2015. http://hdl.handle.net/11427/33228.

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We proposed that the development of a new high capacity polymer microsphere technology, termed ReSyn, could be developed as viable detection reagents for lateral flow technology. This body of work outlines the development of this new high capacity polymer microsphere technology for suitability to flow on lateral flow membranes, and highly specific biomarker detection for immunoassay development. Proof-of-concept was achieved using hCG (pregnancy biomarker) and validated for detection of pLDH and HRP2 as biomarkers of malaria. The sensitivity, stability and multiplex capability of these microsp

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Swann, Olivia Veronica Fowell. "Role of the Swain-Langley and McCoy polymorphisms in complement receptor 1 in cerebral malaria." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/33280.

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Malaria has been a major driving force in the evolution of the human genome. In sub-Saharan African populations, two neighbouring polymorphisms in the Complement Receptor 1 (CR1) gene, named Swain-Langley (Sl2) and McCoy (McCb), occur at high frequencies, consistent with selection by malaria. This thesis investigates the association between these two polymorphisms and severe malaria. Previous studies into this area have produced conflicting findings. Using a large case-control study of severe malaria in Kenyan children and statistical models adjusted for confounders, I found that the Sl2 polym

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26

Голяр, О. І., та А. І. Брей. "Аналіз захворюваності на малярію за 2010 - 2016 рр. у Чернівецькій області". Thesis, Сумський державний університет, 2016. http://essuir.sumdu.edu.ua/handle/123456789/45372.

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Малярія - найпоширеніша в світі трансмісивна протозойна хвороба, спричинювана найпростішими, яка уражає велику кількість людей («Інфекційні хвороби» за редакцією О.А. Голyбовської 2012 р.). За оцінками в 2012 році малярія призвела до 627000 випадків смерті переважно серед африканських дітей. За даними 2012 року, 52 країни знаходяться на шляху зниження рівня захворюваності на малярію на 75 % у відповідності з цілями, поставленими Всесвітньою асамблеєю охорони здоров'я на 2015 рік.

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27

Koch, Oliver. "Common genetic variants of the IFN-γ and IFNGR1 regions : disease associations and functional properties". Thesis, University of Oxford, 2003. http://ora.ox.ac.uk/objects/uuid:30fc15ae-13e5-4150-8093-2582334e75c0.

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There is growing evidence that susceptibility to many inflammatory and infectious diseases may be influenced by our genetic make up. Genetic variants in important immune genes may partially explain variation in susceptibility to common diseases. Interferon-γ (IFNγ) is one of the central mediators of the innate and adaptive immunity and has been implicated in a wide range of infectious and inflammatory disease processes. Severe disruptive mutations in coding regions of the IFN-γ receptor 1 gene (IFNGR1) have been found to be associated with fatal but very rare mycobacterial infections. This stu

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Ocana, Mayorga Sofia Beatriz. "Vector-Borne Diseases Transmission in Ecuador: Implication of Vertebrate Hosts as Food Source of Triatomines in Chagas Disease, and the Diversity of Anopheles Mosquites in Malaria." Ohio University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1579196385136684.

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Noble, Robert John. "Antigenic variation and its evolution in P. falciparum malaria." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:271b8ef9-4e14-42e3-80e6-5584119e20ca.

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This thesis investigates antigenic variation and its evolution in Plasmodium falciparum, the cause of the most deadly form of human malaria. Antigenic variation is a strategy for evading immunity by switching between antigenic variants during infection. In P. falciparum, such variable antigens confer different binding phenotypes that may affect parasite survival and have also been linked to pathology. Here, a new statistical method is described for determining the switching patterns that underlie antigenic variation. This method is then applied to experimental data to yield a full description

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Okoye, Chukwuebuka D., and Ayodeji Segun Bamisile. "Peculiarities of sickle cell anemia in patients with malaria in Africa." Thesis, Sumy State University, 2016. http://essuir.sumdu.edu.ua/handle/123456789/47876.

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Background. Sickle cell anemia is an autosomal recessive disease caused by a single point mutation in nucleobase sequence of chromosome 11 with substitution of glutamic acid by valine and formation of HbS is widespread in mainly African countries with prevalence of 20% - 30% in Cameroon, Republic of Congo, Gabon, Ghana, Nigeria and 45% in Uganda. Malaria on the other hand is an infection caused by a parasite (Plasmodium sp.) that is transmitted to humans by female anopheles mosquito and is prevalent in tropical and subtropical regions of Africa due to increased rainfall, constant high temperat

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Hockham, Carinna. "Exploring the spatial epidemiology and population genetics of malaria-protective haemoglobinopathies." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:9ce0e255-a0b3-44af-af16-f0e6341c40ed.

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Haemoglobinopathies, which include sickle-cell anaemia (SCA) and α- and β-thalassaemia, represent some of our few unequivocal examples of human evolution. The underlying genetic mutations reflect a recurring adaptation against one of the biggest infectious disease killers of humans, Plasmodium falciparum malaria. Inheritance of one copy of a sickle-cell or thalassaemic allele leads to protection against death from malaria, while two copies can result in a severe blood disorder. As a result, haemoglobinopathies have risen in frequency through balancing selection and pose a significant public he

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Meme, Kevin. "The Economics of Life and Death: Rethinking Our Battle with Malaria in a New Era of Disease Control." Thesis, Boston College, 2003. http://hdl.handle.net/2345/429.

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Thesis advisor: Anderson James<br>Malaria kills over 3,000 people each day—mostly in sub-Saharan Africa—and remains the world's number one killer of children under five. While efforts to combat the disease were largely successful in past decades, eradication has since stalled as the parasite (and its mosquito vector) have retreated to the core tropics and become increasingly resistant to pesticides and anti-malarial drugs. This study seeks to determine what other factors are significant in producing high malaria rates, and, based on those results, to offer policy suggestions that may provide a

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33

Merchant, Farid. "Simulating the Spread of Malaria: A Cellular Automaton Based Mathematical Model & A Prototype Software Implementation." Thesis, Virginia Tech, 2007. http://hdl.handle.net/10919/31313.

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Every year three million deaths are attributed to malaria, of which one-third are of children. Malaria is a vector-borne disease, where a mosquito acts as the vector that transmits the disease. In the last few years, computer simulation based models have been used effectively to study the vector population dynamics and control strategies of vector-borne diseases. Typically, these models use ordinary differential equations to simulate the spread of malaria. Although these models provide a powerful mechanism to study the spread of malaria, they have several shortcomings. The research in this the

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Matook, Elaina. "A Look in the Mirror - Daring to Face the Truth about Malaria." Thesis, Boston College, 2007. http://hdl.handle.net/2345/503.

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Thesis advisor: Susan A. Michalczyk<br>Malaria is a curable, preventable disease which has been around for millennia. Unfortunately, in this time of unprecedented growth and resources, the world has yet to prevent malaria from continuing its vicious cycle, taking the life of a child every thirty seconds. This project is an interdisciplinary creative writing exploration of the underlying biological, sociological, and theological reasons for this failure to eradicate an avoidable illness. Aside from the biological difficulties involved in creating vaccines for the complex strains of the malaria

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35

Escallon, Herkrath Camilo. "Reproductive physiology, avian malaria, and the cloacal microbiome in tropical Rufous-collared Sparrows (Zonotrichia capensis)." Diss., Virginia Tech, 2015. http://hdl.handle.net/10919/77854.

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Life-history strategies are adaptations in behavior, physiology, and anatomy that influence survival and reproductive success. Variation in life-history strategies is often determined by adaptations to environmental conditions and trade-offs with sexually-selected signals. One of the aspects controlling life-history trade-offs is the endocrine system. Testosterone is a hormone that mediates several key aspects of male reproduction, yet little is known about the causes and consequences of variation in testosterone. Using rufous-collared sparrows (Zonotrichia capensis), a Neotropical songbird wi

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Llewellyn, David C. C. "Assessment of anti-merozoite antibody function in the context of blood-stage malaria vaccine development." Thesis, University of Oxford, 2014. https://ora.ox.ac.uk/objects/uuid:72e325e5-504c-480a-8b89-6a3ecb73f699.

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In regions endemic for malaria, natural exposure results in an acquired immunity which protects individuals from severe disease. However, no vaccine against the blood-stage of malaria, against which naturally-acquired immunity is targeted, currently exists that is capable of emulating, or out-performing, natural protection. To rationally direct the next generation of blood-stage malaria vaccine development, a greater understanding of the immunological mechanisms involved in clinical protection is required. To date, the assessment of naturally-acquired and vaccine-induced immunity to the blood-

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Alves, R. O. N. "Avian malaria associations with British mosquitoes." Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:dea2e4b0-f4d8-4fae-9209-fa02d083192c.

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Avian malaria (Plasmodium spp.) is a popular model system to study the ecology and evolution of parasite-host-vector interactions in the wild. These studies have historically focused mostly on the avian hosts and the malaria parasites. Knowledge regarding the role of vectors is essential to our understanding of these wild systems, but has only very recently started to accumulate. This thesis aimed to contribute to this field by assessing mosquito-malaria-host associations for British mosquitoes and the role of mosquito ecology in shaping these parasite systems in a British woodland study site,

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Biswas, Sumi. "Prime boost vaccination with viral vectors targeting apical membrane antigen 1." Thesis, University of Oxford, 2013. http://ora.ox.ac.uk/objects/uuid:a17ab4e4-9b81-4ab3-b02f-41d9da36c6ab.

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Apical membrane antigen 1 (AMA1) is a leading candidate vaccine antigen against blood stage malaria and several clinical trials using mostly protein-in-adjuvant vaccines have shown limited success. This thesis describes the development of recombinant adenoviral (AdHu5) and poxviral (MVA) vectors encoding AMA1 from Plasmodium chabaudi murine parasites. In this murine malaria model, AdHu5 and MVA encoding AMA1 when used in a heterologous prime boost regime showed excellent immunogenicity, both humoral and cellular. The vaccination regime was protective against blood stage challenge and both anti

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Fernandez-Reyes, Delmiro. "Association of polymorphisms in intercellular adhesion molecule-1 (ICAM-1) with severe disease in Plasmodium falciparum malaria." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299524.

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Alegana, Victor A. "Developing empirical space-time models of health services for the treatment of malaria to estimate disease incidence." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/378693/.

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VALLONE, ALESSANDRA. "INVESTIGATION OF NOVEL THERAPEUTIC TOOLS AGAINST INFECTIOUS DISEASES Part 1. Medicinal Chemistry Investigation of MMV019918 Derivatives as Dual Schizonticide And Gametocytocidal Agents Against Plasmodium falciparum Part 2. Investigation of 5-Aryl-Heterocycles As Potential Inhibitors of Metallo beta-Lactamase Enzymes." Doctoral thesis, Università di Siena, 2017. http://hdl.handle.net/11365/1004943.

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Among infectious diseases, two large groups have great clinical relevance: parasitic and bacterial infections. Belonging to the first category is malaria, caused by the parasite Plasmodium falciparum. Transmission of Plasmodium parasites between humans and Anopheles mosquitoes is one of the most important contributors to the global impact of malaria and to the difficulties encountered in eliminating this parasite1 . Gametocytogenesis, the process by which merozoites switch from asexual replication to produce male and female gametocytes, represents a critical step in malaria transmission

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Idahosa, Kenudi Christiana. "Bayliss-Hillman adducts as scaffolds for the construction of novel compounds with medicinal potential." Thesis, Rhodes University, 2012. http://hdl.handle.net/10962/d1006763.

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This project has focused on exploring the application of Baylis-Hillman (BH) {a.k.a. Morita-Baylis-Hillman (MBH)} scaffolds in the construction of various compounds with medicinal potential. A series of 2-nitrobenzaldehydes has been treated under BH conditions, with two different activated alkenes, viz., (MVK) and methyl acrylate, using (DABCO) or (3-HQ) as catalyst. While most of the BH reactions were carried out at room temperature, some reactions were conducted using microwave irradiation. The resulting BH adducts have been subjected to dehydration, conjugate addition and allylic substituti

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Sola, Lao Irene. "Novel approaches toward anti-Alzheimer and antiprotozoal drug candidates." Doctoral thesis, Universitat de Barcelona, 2016. http://hdl.handle.net/10803/399594.

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This PhD Thesis pursues the development of novel anti-Alzheimer and antiprotozoal drug candidates upon exploitation of three different novel approaches: Multitarget therapies, Drug repurposing, and Validation of a novel anti-malarial target. The work carried out in the frame of this PhD Thesis has followed three research lines, thus dividing the next report on three main objectives, namely the development of novel diseasemodifying anti‐Alzheimer agents, novel potential 4-aminoquinoline-based anti tripanosomatid compounds, and so far unexplored substrate analog PfG6PD inhibitors for the trea

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Sharma, Raveena. "A Preventable Yet Deadly Disease: An Analysis of Differential Methods to Control Malaria in Regions of High Prevalence." Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/297754.

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Insect-borne diseases contribute to high death rates, especially in developing nations around the world. Malaria is one such disease that causes thousands of deaths annually despite being a preventable and curable disease. Malaria is transmitted through the female Anopheles mosquito and there are four major types of Plasmodium parasite species that can cause the disease in humans. It is prevalent in regions such as the Americas, South Asia and Sub Saharan Africa. It is important to analyze the methods of controlling the vector and the parasite in the regions where malaria is most prevalent so

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Ye, Albert Shanbuo. "Development and Application of Lysate Microarray Technology for Quantitative Analysis of Human Disease." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:11024.

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Reductionist biology has yielded tremendous insight into the basis of biochemistry and genetic disease. However, the remarkable failure of reductionist biology to explain complex problems, especially cancer, has led to the development of systems biology. The vast complexity of biological systems remains the most difficult problem in biology today. In order to understand this complexity, we need tools to massively multiplex measurements of a signaling network. Therefore, we developed lysate microarray technology to fill this need. In this work, we discuss three ways in which lysate microarrays

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Swanson, Bethany L. "Genetic Characterization of Avian Malaria Parasites Across the Breeding Range of the Migratory Lark Sparrow (Chondestes grammacus)." Bowling Green State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1355943191.

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47

Loucoubar, Cheikh. "Statistical genetic analysis of infectious disease (malaria) phenotypes from a longitudinal study in a population with significant familial relationships." Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00685104.

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Long term longitudinal surveys have the advantage to enable several sampling of the studied phenomena and then, with the repeated measures obtained, find a confirmed tendency. However, these long term surveys generate large epidemiological datasets including more sources of noise than normal datasets (e.g. one single measure per observation unit) and potential correlation in the measured values. Here, we studied data from a long-term epidemiological and genetic survey of malaria disease in two family-based cohorts in Senegal, followed for 19 years (1990-2008) in Dielmo and for 16 years (1993-2

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48

Griffiths, Michael J. "Integrated approach to identifying genes critical in the response to malaria using gene expression profiling and disease association analyses." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.491498.

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Chapman, David Eric. "The relationship of parasite burden, sequestration, parasite strain and cytokines to disease in a rodent model of severe malaria." Thesis, Queen Mary, University of London, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244724.

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50

Gessner, Richard Klaus. "Synthesis and structure-activity relationship studies of novel anti-infectives for cross screening in tuberculosis and malaria disease models." Doctoral thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/6308.

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Includes abstract.<br>Includes bibliographical references (p. 205).<br>Some 12-16 hours after the invasion of the human erythrocyte by the malaria parasite Plasmodium falciparum, there appear in the erythrocyte membrane ‘new permeability pathways’ which mediate an increased permeability of the infected cell to a range of low molecular weight solutes, including anions, cations, amino acids, polyols and nucleosides. There is evidence that the pathways have an important bi-functional role: firstly, that the new permeability pathways are required for the uptake of essential nutrients, and secondly

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