Academic literature on the topic 'Malaria Dissertations'

There is lack of evidence on which of the two highly recommended malaria prevention methods, insecticide treated bednets and indoor residual spraying, is more effective than the other. There is also limited peer reviewed literature that compares the characteristics of people who use the two malaria prevention methods. Based on the Health Belief Model, the research questions tested whether there is any relationship between the use of mosquito bednet or the use of indoor residual spraying and contracting malaria, and whether there is any relationship between sociodemographic and socioeconomic factors and the use of malaria prevention methods. Using a quantitative research design, secondary data from the 2011 Angola malaria indicator survey were analyzed. Chi-square for association, logistic regression, and multinomial logistic regression tests were used. There was no statistically significant association between the use of mosquito bednet and having malaria. However, the use of indoor residual spraying significantly reduced the likelihood of getting malaria. There was also a statistically significant association between place of residence, wealth index, level of education, and number of household members and using mosquito bednet and between wealth index and using indoor residual spraying. In conclusion, the malaria prevention programs should focus on indoor residual spraying. It is recommended that all households in southern Africa malaria prone areas should be regularly sprayed. The findings of this study contribute to positive social change in the sense that by using more effective malaria prevention method, individuals will be able to function normally on daily basis, save on expenses related to employment loses or treatment and care of the sick, as well as loss of life and improve own economic status.

Malaria is still an epidemic in many parts of the world-about 220 million people are still infected with malaria worldwide and about 700 thousand people die from this disease per year. Most of the drugs used to treat malaria work well if they are used as required and they contain the right amounts of the active ingredient; however, it is estimated that more than 10% of drugs traded worldwide are counterfeits including 38% to 53% of antimalarial tablets produced in China and India. Due to the lack of data covering the extent of counterfeit antimalarial drugs in Ghana, the purpose of this quantitative study was to determine the percentage of counterfeit antimalarial drugs sold in Ghana by assessing the amounts of the 2 most common antimalarial drugs, artemether (ATMT) and lumefantrine (LMFT) in drugs sold in Ghana retail outlets. These drugs were purchased from retail outlets in Ghana and analyses at the Mayo Clinic Pharmacology core lab (Rochester, MN). The quality of the drugs were characterized by comparing the actual amount of ATMT & LMFT in each tablet to the expected amount. Using explanatory theory along with dose response-response occupancy theory, the researcher addressed quantitative solutions to questions related to the percentage and distribution of counterfeit ATMT and LMFT tablets. The results revealed that overall 20% of the drugs are counterfeit; this is not dependent on the location or kind of outlet but rather depends on whether the tablets were imported or locally manufactured and whether the tablets had a pedigree scratch panel. This study provides a better understanding of how much antimalarial medication is counterfeit in Ghana, which will aid interventions to minimize the adverse effects of counterfeit antimalarial medication in Ghana

Malaria infection has been and continues to be a serious public health concern that has mystified many in the public health care industry. One area in Sub Saharan Africa that continues to feel the devastating effects of malaria is in Nairobi, Kenya. This qualitative research study explored the attitudes of women in Nairobi, Kenya and how they view intervention measures already introduced by public health care experts in fighting malaria. The phenomenological research approach used purposeful sampling to recruit 16 women from Nairobi, Kenya to participate in semi-structured, open-ended interviews. The ecological systems theory was used as a lens of analysis to help illuminate the views of women on already-introduced malaria intervention measures in Nairobi, Kenya. Nvivo 10 helped manage data and the interpretative phenomenological analysis was used to analyze data and identify themes and subthemes through coding. The findings from this study indicate that (a) there is a disconnect within the systems, especially between public health officials and ordinary citizens, and (b) ordinary citizens felt that intervention measures already introduced have not been effectively implemented. The recommendations derived from the study will improve relationships between public health officials and ordinary citizens in order to effectively implement malaria control measures already introduced. This study will benefit public health officials, ordinary citizens in Nairobi, and other health care providers all over the world. This study contributes to social positive change by providing greater insight on already-introduced mosquito intervention measures.

Malaria is a vector borne, acute febrile illness, caused by Plasmodium parasites. Malaria impacts the medical and socioeconomic development programs of affected communities, as it diverts both individual and national resources into managing the disease burden. The purpose of this study was to explore and evaluate household determinants of malaria in Mutasa District, Zimbabwe. The precede-proceed theoretical model guided the study. Secondary data from Demographic Health Survey and District Health Management Information System, and current data from household determinant questionnaires, were used to evaluate the influence and significance of identified household determinants. Multiple logistic regression models were used to examine the association between malaria prevalence and the identified household determinant factors. The study result showed the existence of household determinant factors that affected the prevalence of malaria in Mutasa District. The presence of livestock animals within a 50-meter radius of the household, ownership of animal drawn carts and low socioeconomic status significantly increased malaria risk, while availability of drinking water within a 50-meter radius of the household, significantly reduced malaria risk. Other variables, although not statistically significant, had varied levels of malaria infection risk. The study results may contribute to positive social change by providing an insight into innovative strategies that enhance existing interventions. The study results may also provide opportunities for upgrading malaria intervention policies and sustainable community participation, thus enhancing malaria elimination efforts

Despite the availability of effective drugs to prevent malaria during pregnancy using intermittent preventive treatment with Sulfadoxine-Pyrimethamine or Fansidar and insecticide bed net, use of these methods are still little used in Sub-Saharan Africa, including Tanzania. As a result, many pregnant women are at risk of malaria consequences such as maternal anemia and low birth weight babies, which increase the rate of infant mortality. Data from the Demographic Health Survey for Tanzania HIV/AIDs and the Malaria Indicator Survey 2011-2012 were used in a cross-sectional design guided by the health belief model. Logistic regression examined the association between (a) preventive treatment-seeking behavior and (b) SES, malaria media exposure, knowledge of malaria signs and symptoms, perceived seriousness of malaria, and knowledge of malaria preventive measures. After controlling for transportation, family responsibility, and age, significant associations (p < 0.05) were found between SES, malaria media exposure, knowledge of malaria signs and symptom, perceived seriousness of malaria, knowledge of malaria preventive measures, and treatment-seeking behavior. This study contributes to positive social change by helping design and implement policies and programs to improve the knowledge of Tanzanian pregnant women about the risk of malaria infection and the benefits of preventive treatments. Interventions to reduce malaria infection during pregnancy will reduce the associated morbidity and mortality of both mothers and infants; as a result, families and communities will be healthier and prevent unnecessary medical cost of malaria.

Thesis (MSc)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: The high sickle cell gene frequency has been hypothesised to be related to the protective advantage against malaria disease among heterozygous individuals. In this thesis, we study the interaction between the dynamics of malaria and sickle cell gene. The main aim is to investigate the impact of malaria treatment on the frequency of sickle cell gene. For this, we develop a mathematical model that describes the interactions between malaria and sickle cell gene under malaria treatment. The model includes both homozygous for the normal gene (AA) and heterozygous for sickle cell gene (AS) and assumes that AS individuals are not treated since they do not show clinical symptoms. We first analyse the model without malaria treatment, using singular perturbation techniques, basing on the fact that epidemiological and demographical dynamics occur on two different time scales (fast and slow dynamics). Our analysis on the fast time scale shows that high sickle cell gene frequency leads to high endemic levels for longer duration of parasitemia among heterozygous individuals. However, if the duration of parasitemia is reduced then high sickle cell gene frequency is associated with low endemic levels. We also note that on the slow time scale, the invasion ability of sickle cell gene is dependent on the malaria epidemiological parameters. The invasion coefficient given as the difference in the weighted death rates of AA and AS individuals is used as a measure to determine the establishment of sickle cell gene in the population. Results show that, the gene may establish itself if the weighted death rate of AA individuals is greater than that of AS individuals otherwise it fails. We note that, high mortality of AA individuals leads to establishment of sickle cell gene in the population. Then we analysed the model with treatment, our results indicate that the frequency of sickle cell gene decreases with an increase in the recovery rate of AA individuals. We thus conclude that eradication of malaria disease will lead to a reduction in sickle cell gene frequency.<br>AFRIKAANSE OPSOMMING: Daar word veronderstel dat die hoë sekelsel geenfrekwensie onder heterosigotiese individue verwant is aan die beskermende voordeel teen malaria siekte. In hierdie verhandeling ondersoek ons die wisselwerking tussen die dinamika van malaria en die sekelsel geen. Die hoofdoel is om die invloed van malaria behandeling op die frekwensie van die sekelsel geen te ondersoek. Hiervoor het ons ‘n wiskundige model ontwikkel, wat die wisselwerking tussen die dinamika van malaria en die sekelsel geen met malaria behandeling, beskryf. Die model sluit beide homosigotiese vir die normale geen (AA) en heterosigotiese vir die sekelsel geen (AS) in, en neem aan dat AS individue nie behandel is nie omdat hulle nie die eerste kliniese simptome getoon het nie. Ons ontleed eers die model sonder malaria behandeling, deur gebruik te maak van enkelvoudige pertubasie tegnieke, wat gegrond is op die feit dat epidemiologiese en demografiese dinamika plaasvind op twee verskillende tydskale (vinnige en stadige dinamika). Ons ontleding op die vinnige tydskaal dui dat hoë sekelsel geenfrekwensie onder heterosigotiese individue lei tot hoë endemiese vlakke vir ‘n langer duur van parasitemie. Nietemin, as die duur van parasitemie afneem, dan word hoë sekelsel geenfrekwensie verbind met lae endemiese vlakke. Ons neem ook waar dat op die stadige skaal die indringingsvermoë van die sekelsel afhanklik is van malaria se epidemiologiese parameters. Die indringingskoëffisiënt wat bereken word as die verskil van die geweegde sterftekoerse van AA en AS individue, word gebruik as ‘n maatstaf om die vestiging van die sekelsel geen in die bevolking te bepaal. Resultate toon dat die geen homself kan vestig as die geweegde sterftekoers van AA individue groter is as di e van die AS individue, andersins misluk dit. Ons let op dat hoë mortaliteit van AA individue lei tot die vestiging van die sekelsel geen in die bevolking. Daarna het ons die model wat behandeling insluit ge-analiseer en ons resultate toon dat die frekwensie van die sekelsel geen afneem met ‘n toename in die herstelkoers van AA individue. Ons kom dus tot die gevolgtrekking dat die uitwissing van malaria siekte sal lei tot die afname in sekelsel geenfrekwensie.

Malaria is a vector-borne disease that presents the most persistent and serious public health burden in Liberia. Numerous studies have examined the relationship between ITN use and malaria prevalence. However, little research has explored the effectiveness of ITNs in controlling malaria among children in postwar Liberia. The aim of this study was to examine the association between ITN ownership, parental economic status, ITN installation support, and malaria prevalence among children. This was a quantitative cross-sectional study guided by the health belief model. The study used secondary data from the 2011 Liberia Malaria Indicator Survey. Chi-square for association and Logistic regression were used to analyze the data. The results revealed a significant association between parental education and malaria prevalence. There was also a significant association between parental economic status and malaria prevalence. However, there was no significant association between ITN ownership and malaria prevalence after controlling for parental education and ownership of structure. These findings may foster social change by helping public health authorities in Liberia integrate ITN use with other strategies like mosquito larvae elimination and indoor/outdoor insecticide spraying as part of a comprehensive approach to malaria control. Additionally, massive awareness and economic capacity building should be undertaken to empower malaria endemic communities with the understanding that malaria can be rapidly reduced with other robust strategies in combination with ITN use. These strategies, if implemented, may effectively control malaria prevalence among children and the emotional and financial burdens endure by their families.