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Journal articles on the topic 'Malaria parasitemia'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Prata, Aluizio, Margarita Urdaneta, Patrick B. McGreevy, and Mauro Shugiro Tada. "Infrequency of asymptomatic malaria in an endemic area in Amazonas, Brazil." Revista da Sociedade Brasileira de Medicina Tropical 21, no. 2 (1988): 51–54. http://dx.doi.org/10.1590/s0037-86821988000200003.

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A malaria survey was conducted in an area of high transmission (Costa Marques, Rondonia, Brazil) to determine the prevalence of asymptomatic parasitemia and its clinical significance. Most of the people surveyed were immigrants who had lived in the endemic area < 5 years. The people had easy access to free diagnostic and treatment services at the Malaria Clinic in the town of Costa Marques. The prevalence of plasmodial parasitemia in 344 people was 22%. There were 36 individuals with asymptomatic infections among the 77 parasitemic patients. During the two days following the initial examina

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Kifude, Carolyne, Deborah Stiffler, David Rockabrand, et al. "Asymptomatic falciparum and Non-falciparum Malarial Parasitemia in Adult Volunteers with and without HIV-1 Coinfection in a Cohort Study in Western Kenya." American Journal of Tropical Medicine and Hygiene 105, no. 1 (2021): 159–66. http://dx.doi.org/10.4269/ajtmh.21-0012.

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Abstract.Asymptomatic malarial parasitemia represents the largest reservoir of infection and transmission, and the impact of coinfection with HIV-1 on this reservoir remains incompletely described. Accordingly, we sought to determine the prevalence of asymptomatic malarial parasitemia in Kombewa, Western Kenya, a region that is endemic for both malaria and HIV-1. A total of 1,762 dried blood spots were collected from asymptomatic adults in a cross-sectional study. The presence of parasitemia was first determined by a sensitive Plasmodium genus–specific 18S assay, followed by less sensitive spe

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Cheruiyot, Agnes C., Jennifer M. Auschwitz, Patricia J. Lee, et al. "Assessment of the Worldwide Antimalarial Resistance Network Standardized Procedure forIn VitroMalaria Drug Sensitivity Testing Using SYBR Green Assay for Field Samples with Various Initial Parasitemia Levels." Antimicrobial Agents and Chemotherapy 60, no. 4 (2016): 2417–24. http://dx.doi.org/10.1128/aac.00527-15.

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ABSTRACTThe malaria SYBR green assay, which is used to profilein vitrodrug susceptibility ofPlasmodium falciparum, is a reliable drug screening and surveillance tool. Malaria field surveillance efforts provide isolates with various low levels of parasitemia. To be advantageous, malaria drug sensitivity assays should perform reproducibly among various starting parasitemia levels rather than at one fixed initial value. We examined the SYBR green assay standardized procedure developed by the Worldwide Antimalarial Resistance Network (WWARN) for its sensitivity and ability to accurately determine

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Fogang, Balotin, Marie Florence Biabi, Rosette Megnekou, et al. "High Prevalence of Asymptomatic Malarial Anemia and Association with Early Conversion from Asymptomatic to Symptomatic Infection in a Plasmodium falciparum Hyperendemic Setting in Cameroon." American Journal of Tropical Medicine and Hygiene 106, no. 1 (2022): 293–302. http://dx.doi.org/10.4269/ajtmh.21-0316.

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ABSTRACT. Asymptomatic malarial parasitemia is highly prevalent in Plasmodium falciparum endemic areas and often associated with increased prevalence of mild to moderate anemia. The aim of this study was to assess the prevalence of anemia during asymptomatic malaria parasitemia and its interplay with persistent infection in highly exposed individuals. A household-based longitudinal survey was undertaken in a malaria hyperendemic area in Cameroon using multiplex nested polymerase chain reaction to detect plasmodial infections. Residents with P. falciparum asymptomatic parasitemia were monitored

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Ashraf, Shoaib, Areeba Khalid, Arend L. de Vos, Yanfang Feng, Petra Rohrbach, and Tayyaba Hasan. "Malaria Detection Accelerated: Combing a High-Throughput NanoZoomer Platform with a ParasiteMacro Algorithm." Pathogens 11, no. 10 (2022): 1182. http://dx.doi.org/10.3390/pathogens11101182.

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Eradication of malaria, a mosquito-borne parasitic disease that hijacks human red blood cells, is a global priority. Microscopy remains the gold standard hallmark for diagnosis and estimation of parasitemia for malaria, to date. However, this approach is time-consuming and requires much expertise especially in malaria-endemic countries or in areas with low-density malaria infection. Thus, there is a need for accurate malaria diagnosis/parasitemia estimation with standardized, fast, and more reliable methods. To this end, we performed a proof-of-concept study using the automated imaging (NanoZo

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Yusroh, Yoyoh, Bidasari Lubis, Syahril Pasaribu, Munar Lubis, Tiangsa Sembiring, and Adillida Adillida. "Hemolytic anemia in falciparum and vivax malarial patients based on serum bilirubin examination." Paediatrica Indonesiana 44, no. 3 (2016): 95. http://dx.doi.org/10.14238/pi44.3.2004.95-100.

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Objective To examine hemolysis in falciparum and vivax malarialpatients based on serum bilirubin examination.Methods A cross sectional study was conducted on childrenyounger than 15 years of age who visited public health center inthe district of Mandailing Natal with complaints of fever, shivering,pale, jaundice, diarrhea, or headache between April 9 th and April19 th 2001. Variables recorded were age, gender, body weight, bodyheight, symptoms and signs, anti malarial drugs, and laboratorytest results. Thin and thick blood smears were done as diagnostictools of malaria. Thin blood smear was al

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Ouédraogo, Alphonse, Alfred B. Tiono, Amidou Diarra, et al. "Transplacental Transmission ofPlasmodium falciparumin a Highly Malaria Endemic Area of Burkina Faso." Journal of Tropical Medicine 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/109705.

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Malaria congenital infection constitutes a major risk in malaria endemic areas. In this study, we report the prevalence of transplacental malaria in Burkina Faso. In labour and delivery units, thick and thin blood films were made from maternal, placental, and umbilical cord blood to determine malaria infection. A total of 1,309 mother/baby pairs were recruited. Eighteen cord blood samples (1.4%) contained malaria parasites(Plasmodium falciparum). Out of the 369 (28.2%) women with peripheral positive parasitemia, 211 (57.2%) had placental malaria and 14 (3.8%) had malaria parasites in their umb

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Makani, Julie, Albert N. Komba, Sharon E. Cox, et al. "Malaria in patients with sickle cell anemia: burden, risk factors, and outcome at the outpatient clinic and during hospitalization." Blood 115, no. 2 (2010): 215–20. http://dx.doi.org/10.1182/blood-2009-07-233528.

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Abstract Approximately 280 000 children are born with sickle cell anemia (SCA) in Africa annually, yet few survive beyond childhood. Falciparum malaria is considered a significant cause of this mortality. We conducted a 5-year prospective surveillance study for malaria parasitemia, clinical malaria, and severe malarial anemia (SMA) in Dar-es-Salaam, Tanzania, between 2004 and 2009. We recorded 10 491 visits to the outpatient clinic among 1808 patients with SCA and 773 visits among 679 patients without SCA. Similarly, we recorded 691 hospital admissions among 497 patients with SCA and 2017 in p

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Iram, Shagufta, Muhammad Saeed, Shahida Hussain, Ayesha Mobeen, Rabia Jabbar, and Maleeha Aslam. "BURDEN OF MALARIAL PARASITEMIA." Professional Medical Journal 23, no. 04 (2016): 428–33. http://dx.doi.org/10.29309/tpmj/2016.23.04.1501.

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Background : Hematology: 21st century is evolutionary in the arena of medicallaboratory sciences but immunological adverse reactions of blood transfusion and possibletransmission of transfusion transmissible infections are still in their peak. Transmission ofplasmodium via blood is significantly important because only a small fraction of infected redcells of donor blood can lead to cause malarial parasitemia in the recipient. Present studywas planned to determine the frequency of Transfusion based transmissible malaria amongapparently healthy blood donors. Method: This study was conducted in t

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Stevenson, Mary M., Zhong Su, and Mariela Segura. "Regulatory T cells (Tregs) contribute to suppression of anti-malarial immunity by concurrent nematode infection (51.1)." Journal of Immunology 178, no. 1_Supplement (2007): S96. http://dx.doi.org/10.4049/jimmunol.178.supp.51.1.

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Abstract Here, we investigated the mechanisms involved in modulation of anti-malarial immunity by concurrent nematode infection. Both WT C57BL/6 (B6) and STAT-6 deficient (KO) mice co-infected with the gastrointestinal nematode Heligmosomoides polygyrus (Hp) 2 wk prior to blood-stage Plasmodium chabaudi AS (Pc) infection had significantly higher parasitemias and significantly lower serum IFN-γ levels compared to their respective controls infected with Pc alone. Hp-infected STAT-6 KO compared to WT mice produced significantly lower levels of Th2 cytokines (IL-4, IL-13) but Tregs (CD4+CD25+Foxp3

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Ranoko, Merylin, Aryati Aryati, and Arifoel Hajat. "CORRELATION BETWEEN WDF, WNR, AND RET ABNORMAL SCATTERGRAM DETECTED BY SYSMEX XN-1000 AND PARASITEMIA OF MALARIA PATIENTS IN MERAUKE HOSPITAL." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 26, no. 1 (2019): 91. http://dx.doi.org/10.24293/ijcpml.v26i1.1521.

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Malaria remains a health problem in Indonesia. Microscopic examination with Giemsa staining is the gold standard for diagnosing malaria. The density of parasites correlates with the degree of severity and response to therapy of malaria. Malaria-causing plasmodium can be detected by Sysmex XN-1000 which is marked by abnormalities in the WDF, WNR and RET scattergram. This research aimed to determine the correlation of WDF, WNR and RET abnormal scattergram detected by Sysmex XN-1000 and the parasitemia index of malaria at the Merauke General Hospital. This was a cross-sectional study with observa

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Nurmansyah, Dian, Maulisa Khasanah, Rizka Ayu Wahyuni, and Puspawati Puspawati. "Malaria Density in Peripheral Blood Smear on Positive Cases of Malaria on Residences of Jaro South Kalimantan." Jurnal Analis Medika Biosains (JAMBS) 11, no. 2 (2024): 112. https://doi.org/10.32807/jambs.v11i2.375.

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Malaria, a severe infectious disease caused by Plasmodium parasites, remains a significant health challenge in endemic regions of Indonesia, particularly in areas with favorable environmental conditions for Anopheles mosquitoes. The liver is a critical organ involved in the early stages of malaria infection. This study investigates malaria density in confirmed malaria cases in Jaro District, South Kalimantan. The aims of this study was to determine the parasitemia density in individuals diagnosed with malaria in the Jaro District, contributing to the understanding of malaria severity in this r

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Sada, M., A. M. Legowo, and G. Anjani. "Study of goat milk and goat milk yogurt to decrease parasitemia index on malaria-infected mice." Food Research 4, S3 (2020): 127–33. http://dx.doi.org/10.26656/fr.2017.4(s3).s26.

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Malaria is an infectious disease caused by the Plasmodium sp. parasite. In 2017, malaria has reached 219 million cases. The decline of parasitemia index indicates a lower degree of infection in malaria patients. Goat milk and goat milk yogurt as immunomodulators have the potential to reduce parasitemia index. This study was aimed to determine the effect of goat milk and goat milk yogurt on the index of parasitemia in malaria-infected mice. This research was a true experimental study with a post-test only group design. A total of thirty-five female Balb/c mice was divided into the following gro

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Boutlis, Craig S., Emiliana Tjitra, Helena Maniboey, et al. "Nitric Oxide Production and Mononuclear Cell Nitric Oxide Synthase Activity in Malaria-Tolerant Papuan Adults." Infection and Immunity 71, no. 7 (2003): 3682–89. http://dx.doi.org/10.1128/iai.71.7.3682-3689.2003.

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ABSTRACT Individuals living in regions of intense malaria transmission exhibit natural immunity that allows them to be without fever and other symptoms for most of the time despite frequent parasitization. Although this tolerance of parasitemia appears to be more effective in children than in adults (as evidenced by lower parasitemia fever thresholds with age), adults do exhibit a degree of tolerance but the mechanism(s) underlying this are unclear. Asymptomatic malaria-exposed children have higher levels of nitric oxide (NO) than children with severe disease, and NO has been proposed as a med

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Jason, Janine, Lennox K. Archibald, Okey C. Nwanyanwu, et al. "Cytokines and Malaria Parasitemia." Clinical Immunology 100, no. 2 (2001): 208–18. http://dx.doi.org/10.1006/clim.2001.5057.

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Salutondok, Welly, Nolly O. H. Rantung, Ronny ., and Michelle P. C. Nugroho. "A Case Report of Plasmodium Malaria Infection." Galore International Journal of Health Sciences and Research 9, no. 4 (2025): 105–8. https://doi.org/10.52403/gijhsr.20240411.

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Background: Malaria is a human infection caused by Plasmodium species. The Indonesia Ministry of Health reported 418,546 positive cases of malaria in Indonesia throughout 2023. Among the five major Plasmodium species, Plasmodium malariae infection is relatively rare and often overlooked by light microscopy due to its low parasitemia. Case Report: A 67-year-old female presented to the emergency room with a fever for almost one week. The fever went down for three days but rose again on the fourth day. The patient had a history of traveling to Papua. Vital signs were normal. Laboratory examinatio

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Wamae, Kevin, Juliana Wambua, George Nyangweso, et al. "Transmission and Age Impact the Risk of Developing Febrile Malaria in Children with Asymptomatic Plasmodium falciparum Parasitemia." Journal of Infectious Diseases 219, no. 6 (2018): 936–44. http://dx.doi.org/10.1093/infdis/jiy591.

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Abstract Background Plasmodium falciparum infections lead to febrile illness unless the host has sufficient immunity, in which case infection may cause no immediate symptoms (ie, “asymptomatic parasitemia”). Previous studies are conflicting on the role of asymptomatic parasitemia in determining the risk of developing febrile malaria. Methods We monitored 2513 children (living in Kilifi, Kenyan Coast) by blood smears in 17 cross-sectional surveys to identify asymptomatic parasitemia and used active surveillance over 11325 child-years of follow-up to detect febrile malaria. We evaluated the inte

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Ogamba, Stella Ekene, Joseph Ifeanyi Brian-D. Adinma, Nneoma Dolores Adinma-Obiajulu, et al. "Prevalence, and Biosocial Associations, of Malaria Parasitemia in Pregnant Women from Southeastern Nigeria." Journal of the Nigerian Academy of Medicine 3, no. 1 (2024): 8–13. http://dx.doi.org/10.4103/jnam.jnam_1_24.

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Abstract Background: Malaria in pregnancy is a globally recognized cause of feto-maternal morbidity and mortality. Certain bio-social characteristics may be associated with malaria in pregnancy. Objective: To determine the prevalence, and some bio-social associations, of malaria parasitemia in pregnant women from southeastern Nigeria. Subjects and Methods: This is a prospective cross-sectional study of 330 pregnant women attending antenatal clinics in health facilities in Nnewi, southeastern Nigeria. Thick and thin blood films were stained with Giemsa to identify malaria parasites; a pro-forma

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Yusuf, Yenni, Rangga Meidianto Asri, Rivaldo Go, et al. "Synergism of Anti-Malarial Effect of Carica papaya L. and Moringa oleifera Leaf Extracts in Mice." Majalah Obat Tradisional 29, no. 1 (2024): 101. http://dx.doi.org/10.22146/mot.86703.

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Malaria parasites, Plasmodium spp, can develop resistance to anti-malarial drugs. Hence, potential alternative therapeutic agents should be explored. This research aimed to investigate the anti-malarial effect of a combination of Carica papaya and Moringa oleifera leaf extract. Peter’s test performed on Balb/c mice to investigate the malarial parasite growth inhibition. Mice were infected with Plasmodium berghei by intraperitoneal injection to provoke rodent malaria. After infection, we grouped every 5-6 mice into different treatment groups, including a negative control group, a positive contr

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Boutlis, Craig S., J. Brice Weinberg, Joanne Baker, et al. "Nitric Oxide Production and Nitric Oxide Synthase Activity in Malaria-Exposed Papua New Guinean Children and Adults Show Longitudinal Stability and No Association with Parasitemia." Infection and Immunity 72, no. 12 (2004): 6932–38. http://dx.doi.org/10.1128/iai.72.12.6932-6938.2004.

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ABSTRACT Individuals in areas of intense malaria transmission exhibit resistance (or tolerance) to levels of parasitemia in their blood that would normally be associated with febrile illness in malaria-naïve subjects. The resulting level of parasitemia associated with illness (the pyrogenic threshold) is highest in childhood and lowest in adulthood. Clinical parallels between malarial and bacterial endotoxin tolerance have led to the supposition that both share common physiological processes, with nitric oxide (NO) proposed as a candidate mediator. The hypotheses that NO mediates tolerance an

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Emechebe, Cajethan, Andrew Enwa Okpe, Edu Michael Eyong, and Charles Obinna Njoku. "The Rate of Asymptomatic Plasmodium Parasitemia and Placental Parasitization in Urban and Rural Areas of Cross River State, Nigeria." Open Access Macedonian Journal of Medical Sciences 10, B (2022): 438–44. http://dx.doi.org/10.3889/oamjms.2022.8636.

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Background: Malaria in pregnancy contributes to feto-maternal morbidity and mortality even in asymptomatic forms of the disease especially in malaria endemic regions such as Nigeria. Objective: To determine the rate of asymptomatic malaria parasitemia and placental parasitization among the rural and urban pregnant women and its feto-maternal effects in Cross River State, Nigeria. Methodology: This was a prospective study of 440 pregnant women in rural and urban settings. Participants completed structured questionnaire and also have their blood samples and placentas examined for presence of mal

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Ahmed, Mejbah Uddin, Mohammad Akram Hossain, Abul Hossain Khan, and Salah Uddin Ahmed. "Efficacy of Immunodiagnosis of Falciparum Malaria at Different Levels of Parasitemia." Journal of Enam Medical College 3, no. 2 (2013): 88–90. http://dx.doi.org/10.3329/jemc.v3i2.16130.

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Background: Among the several human species of malarial parasites, Plasmodium falciparum can cause severe infection and if left untreated, there may be fatal complications. Early diagnosis and prompt treatment have been proposed to reduce the morbidity and mortality from malaria. Objective: To assess the diagnostic efficacy of antigen detection by immunochromatographic test (ICT) at different levels of parasitemia for diagnosis of malaria. Materials and Methods: This study was carried out in the department of Microbiology, Mymensingh Medical College for a period of one year from July 2005 to J

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Eyong Clinton, Achere, Ndifontiayong Adamu Ndongho, Ntungwen Fokunang Charles, and Shey Nsagha Dickson. "Assessment of malaria parasitemia in people living with HIV/AIDS in Kumba, Cameroon." Open Journal of Tropical Medicine 6, no. 1 (2022): 001–10. http://dx.doi.org/10.17352/ojtm.000021.

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Background: Malaria parasitemia and HIV infections are globally important public health concerns. People residing in regions where these two infections are endemic are prone to develop co-infection. Sub-Saharan Africa has the greatest burden of both diseases and Cameroon particularly the South West Region has been reported as one of the regions with the highest malaria and HIV prevalence. Hence, there is a need for continuous monitoring and epidemiologic inquiry to generate updated data on the burden of malaria parasitemia on HIV/AIDS. The aim of this study was to determine the prevalence of m

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Briggs, Jessica, John Ategeka, Richard Kajubi, et al. "Impact of Microscopic and Submicroscopic Parasitemia During Pregnancy on Placental Malaria in a High-Transmission Setting in Uganda." Journal of Infectious Diseases 220, no. 3 (2019): 457–66. http://dx.doi.org/10.1093/infdis/jiz130.

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In pregnant women assessed for parasitemia every 28 days, the risk of placental malaria increased in a dose-response relationship with both increasing frequency and density of parasitemia; however, even women with only submicroscopic parasitemia were at risk for placental malaria.

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Kho, Steven, Gabriela Minigo, Benediktus Andries, et al. "Circulating Neutrophil Extracellular Traps and Neutrophil Activation Are Increased in Proportion to Disease Severity in Human Malaria." Journal of Infectious Diseases 219, no. 12 (2018): 1994–2004. http://dx.doi.org/10.1093/infdis/jiy661.

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AbstractBackgroundNeutrophil activation results in Plasmodium parasite killing in vitro, but neutrophil products including neutrophil extracellular traps (NETs) mediate host organ damage and may contribute to severe malaria. The role of NETs in the pathogenesis of severe malaria has not been examined.MethodsIn Papua, Indonesia, we enrolled adults with symptomatic Plasmodium falciparum (n = 47 uncomplicated, n = 8 severe), Plasmodium vivax (n = 37), or Plasmodium malariae (n = 14) malaria; asymptomatic P falciparum (n = 19) or P vivax (n = 21) parasitemia; and healthy adults (n = 23) without pa

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Boutlis, Craig S., D. Channe Gowda, Ramachandra S. Naik, et al. "Antibodies to Plasmodium falciparum Glycosylphosphatidylinositols: Inverse Association with Tolerance of Parasitemia in Papua New Guinean Children and Adults." Infection and Immunity 70, no. 9 (2002): 5052–57. http://dx.doi.org/10.1128/iai.70.9.5052-5057.2002.

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ABSTRACT Individuals living in regions of intense malaria transmission exhibit natural immunity that facilitates persistence of parasitemia at controlled densities for much of the time without symptoms. This aspect of immunity has been referred to as malarial “tolerance” and is thought to partly involve inhibition of the chain of events initiated by a parasite toxin(s) that may otherwise result in cytokine release and symptoms such as fever. Antibodies to the candidate Plasmodium falciparum glycosylphosphatidylinositol (GPI) toxin have been viewed as likely mediators of such tolerance. In this

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Tjitra, Emiliana, Sri Suprianto, Mary Dyer, Bart J. Currie, and Nicholas M. Anstey. "Field Evaluation of the ICT Malaria P.f/P.v Immunochromatographic Test for Detection of Plasmodium falciparum andPlasmodium vivax in Patients with a Presumptive Clinical Diagnosis of Malaria in Eastern Indonesia." Journal of Clinical Microbiology 37, no. 8 (1999): 2412–17. http://dx.doi.org/10.1128/jcm.37.8.2412-2417.1999.

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In areas such as eastern Indonesia where both Plasmodium falciparum and Plasmodium vivax occur, rapid antigen detection tests for malaria need to be able to detect both species. We evaluated the new combined P. falciparum-P. vivaximmunochromatographic test (ICT Malaria P.f/P.v.) in Radamata Primary Health Centre, Sumba, Indonesia, from February to May 1998 with 560 symptomatic adults and children with a presumptive clinical diagnosis of malaria. Blinded microscopy was used as the “gold standard,” with all discordant and 20% of concordant results cross-checked blindly. Only 50% of those with a

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Boutlis, Craig S., Moses Lagog, Sujittra Chaisavaneeyakorn, et al. "Plasma Interleukin-12 in Malaria-Tolerant Papua New Guineans: Inverse Correlation with Plasmodium falciparum Parasitemia and Peripheral Blood Mononuclear Cell Nitric Oxide Synthase Activity." Infection and Immunity 71, no. 11 (2003): 6354–57. http://dx.doi.org/10.1128/iai.71.11.6354-6357.2003.

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ABSTRACT Interleukin-12 (IL-12) has been inversely associated with disease severity in human and murine malaria, and a polymorphism in the IL-12 p40 subunit gene (IL12B) has been associated with susceptibility to human cerebral malaria and reduced nitric oxide (NO) production. To better define the relationships between IL-12, NO, malaria parasitemia, and IL12B polymorphisms during malarial tolerance, plasma IL-12 levels and peripheral blood mononuclear cell NO synthase (NOS) activity were measured in asymptomatic Papua New Guineans exposed to intense malaria transmission. The IL-12 level was s

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Patil, Asha, Vivek Raghavan Muduthan, and Gunavathi Kunder. "Can ESR be a diagnostic marker for assessing the severityof malarial infection? A retrospective study." Bangladesh Journal of Medical Science 18, no. 4 (2019): 756–59. http://dx.doi.org/10.3329/bjms.v18i4.42881.

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Objective: This study aimed to investigate the variation of ESR in malarial infection and find out the variation of ESR in related to the degree of parasitemia. Material and Methods: A retrospective study with a duration of 6 months, on 385 randomly selected positive malaria cases. Their clinical record and lab records were analyzed for ESR level. Result: The sample of 385 positive malaria cases has included both males and females, ages ranged from 15-60 years old. A total number of Plasmodium.falciparumwas 60 (uncomplicated & severe cases) and for Plasmodiumvivax was 325. In P

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Berg, Aase, Sam Patel, Marit G. Tellevik, et al. "Plasma parasitemia as assessed by quantitative PCR in relation to clinical disease severity in African adults with falciparum malaria with and without HIV co-infection." Infection 48, no. 3 (2020): 367–73. http://dx.doi.org/10.1007/s15010-020-01399-3.

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Abstract Purpose When considering malaria disease severity, estimation of parasitemia in erythrocytes is important, but sometimes misleading, since the infected erythrocytes may be sequestered in peripheral capillaries. In African children and Asian adults with falciparum malaria, parasitemia as assessed by quantitative PCR (qPCR) in plasma seems to be a valuable indicator of disease severity, but data on African adults as well as the impact of co-infection with HIV is lacking. Methods In 131 patients with falciparum malaria in a public tertiary teaching hospital in Mozambique, plasma malaria

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Gillman, Brad M., Joan Batchelder, Patrick Flaherty, and William P. Weidanz. "Suppression of Plasmodium chabaudi Parasitemia Is Independent of the Action of Reactive Oxygen Intermediates and/or Nitric Oxide." Infection and Immunity 72, no. 11 (2004): 6359–66. http://dx.doi.org/10.1128/iai.72.11.6359-6366.2004.

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ABSTRACT The killing of blood-stage malaria parasites in vivo has been attributed to reactive intermediates of oxygen (ROI) and of nitrogen (RNI). However, in the case of the latter, this contention is challenged by recent observations that parasitemia was not exacerbated in nitric oxide synthase (NOS) knockout (KO) (NOS2−/− or NOS3−/−) mice or in mice treated with NOS inhibitors. We now report that the time course shows that Plasmodium chabaudi parasitemia in NADPH oxidase KO (p47phox−/−) mice also was not exacerbated, suggesting a minimal role for ROI-mediated killing of blood-stage parasite

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Lailani, Dini, Munar Lubis, Bidasari Lubis, and Syahril Pasaribu. "Correlation between parasitemia and spleen size in patients with P. falciparum infection." Paediatrica Indonesiana 44, no. 3 (2016): 111. http://dx.doi.org/10.14238/pi44.3.2004.111-6.

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Background Spleen is an important organ in immunity to malariainfection which is always affected in malaria patients. Enlargementof the spleen is one of the main clinical symptoms of malaria. Levelof parasitemia is related to the risk of complications.Objective To describe the correlation between parasitemia andspleen size in patients with P.falciparum infection.Methods One hundred and four patients including children andadults with fever, pale, jaundice, diarrhea, and headache who vis-ited public health centers in 5 villages in Mandailing Natal, NorthSumatera were enrolled in this study. The

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Negreiros, Róbson Miguel de Araújo, Fabiano Hiromichi Makimoto, Linda Luciana Oliveira Santana, Luís Carlos de Lima Ferreira, Gerson Suguiyama Nakajima, and Maria Cristina dos Santos. "Experimental splenectomies and malaria in mice." Acta Cirurgica Brasileira 24, no. 6 (2009): 437–41. http://dx.doi.org/10.1590/s0102-86502009000600003.

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PURPOSE: To evaluate the importance of spleen in malaric infection in murino model, comparing the parasitemia and the titles of imunoglobulins in the different groups. METHODS: It was used female mice non-isogenic, in inoculated with Plasmodium berghei, cepa ANKA, intraperitoneally. The parasitemia was analyzed in 23rd, 25th, 27th and 32nd day of the experiment, being the stained blood' exam colored by Giemsa. The titles of the total serum immunoglobulins IgM and IgG were analyzed by Dot-ELISA technique, at 6th, 22nd and 32nd day, when the animals were sacrificed. RESULTS: The parasitemia was

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Mwesigwa, Moses, Jessica L. Webster, Sam Lubwama Nsobya, et al. "Prevalence of Malaria Parasite Infections among U.S.-Bound Congolese Refugees with and without Splenomegaly." American Journal of Tropical Medicine and Hygiene 104, no. 3 (2021): 996–99. http://dx.doi.org/10.4269/ajtmh.20-0924.

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ABSTRACTAll U.S.-bound refugees from sub-Saharan Africa receive presumptive antimalarial treatment before departing for the United States. Among U.S.-bound Congolese refugees, breakthrough malaria cases and persistent splenomegaly have been reported. In response, an enhanced malaria diagnostic program was instituted. Here, we report the prevalence of plasmodial infection among 803 U.S.-bound Congolese refugees who received enhanced diagnostics. Infections by either rapid diagnostic test (RDT) or PCR were detected in 187 (23%) refugees, with 78 (10%) by RDT only, 35 (4%) by PCR only, and 74 (9%

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Gordy, Dominique, Krystalyn Hudson, Tiffany Thomas, Shivang Shah, and Elizabeth Stone. "Monitoring Infected Reticulocytes During Murine Malaria Infection." American Journal of Clinical Pathology 160, Supplement_1 (2023): S141. http://dx.doi.org/10.1093/ajcp/aqad150.304.

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Abstract Malaria infection is a major cause of mortality worldwide. According to the 2022 World Health Organization Malaria Report, malaria caused approximately 247 million infections and 619,000 deaths in 2021, with more than 470,000 children dying of malaria. The gold-standard for measuring parasitemia is counting infected red blood cells (RBCs) by eye using Giemsa staining whole blood smears. This method is time consuming and is subject to error by both who is counting, the number of cells counted, and which frames are selected for counting. Automating the process of measuring malaria infec

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Sultan Mustafa, Waseem Jamalvi, Ibrahim Shakoor, and Sumbal Waheed. "Simple clinical parameters to diagnose Malaria in Outpatient Department." JMMC 9, no. 1 (2019): 4–7. http://dx.doi.org/10.62118/jmmc.v9i1.37.

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Introduction: Malaria is the world's most important parasitic infection which poses major health challenges. Best estimates currently describe the annual global burden of malaria as 300-500 million cases and 1-2 million deaths. Traditionally malaria is diagnosed clinically based upon sign symptoms and clinical examination particularly in remote areas where laboratory facilities are not available. However, no universal criteria exist for clinical diagnosis of malaria and presenting features are highly variable region to region. Therefore, we planned to define the simple parameters based on clin

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TANGPUKDEE, N., S. KRUDSOOD, S. KANO, and P. WILAIRATANA. "Falciparum malaria parasitemia index for predicting severe malaria." International Journal of Laboratory Hematology 34, no. 3 (2012): 320–27. http://dx.doi.org/10.1111/j.1751-553x.2011.01398.x.

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Firdaus, Egy Rahman, Ji-Hoon Park, Fauzi Muh, et al. "Performance Evaluation of Biozentech Malaria Scanner in Plasmodium knowlesi and P. falciparum as a New Diagnostic Tool." Korean Journal of Parasitology 59, no. 2 (2021): 113–19. http://dx.doi.org/10.3347/kjp.2021.59.2.113.

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The computer vision diagnostic approach currently generates several malaria diagnostic tools. It enhances the accessible and straightforward diagnostics that necessary for clinics and health centers in malaria-endemic areas. A new computer malaria diagnostics tool called the malaria scanner was used to investigate living malaria parasites with easy sample preparation, fast and user-friendly. The cultured <i>Plasmodium</i> parasites were used to confirm the sensitivity of this technique then compared to fluorescence-activated cell sorting (FACS) analysis and light microscopic examin

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Akshay, Louis Dias, and D. Sumanth. "Usefulness of Various Peripheral Blood Leukocyte Count ratios in Malaria Evaluation." International Journal of Health Sciences and Pharmacy (IJHSP) 1, no. 2 (2017): 52–60. https://doi.org/10.5281/zenodo.1043523.

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Malaria is a major public health problem in India. Changes in blood cell counts are a well-known feature of malaria. Hence an attempt has been made to assess the role of leucocyte ratios in malaria as predictors of malaria infection and its clinical severity. <strong>Methods:</strong> A retrospective observational cohort study was carried out in a tertiary care teaching hospital over a period of 2 months. A total of 171 samples and 48 controls were included in the study. All the absolute and differential white blood cell counts were done. The neutrophil-lymphocyte count ratio (NLCR), monocyte-

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Bayisa, Gobena, and Mebrate Dufera. "Malaria Infection, Parasitemia, and Hemoglobin Levels in Febrile Patients Attending Sibu Sire Health Facilities, Western Ethiopia." BioMed Research International 2022 (August 12, 2022): 1–8. http://dx.doi.org/10.1155/2022/6161410.

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Background. Malaria is endemic in tropical and subtropical regions and causes up to one million deaths each year. It mostly affects sub-Saharan African countries including Ethiopia. In Ethiopia, it was estimated that about 75% of the land and 68% of the population are exposed to malaria. The aim of the current study was to determine malaria cases, its impact on the level of hemoglobin, and parasitemia and predisposing factors among febrile patients who visited Sibu Sire Health Care centers. Methods. Institution-based cross-sectional study was undertaken from May to October, 2020. Febrile patie

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Girmaw, Fentaw, and Ephrem Engidawork. "In Vivo Anti-Malarial Activity of the Aqueous Root Extract of Euclea divinorum Hiern (Ebenaceae) against Plasmodium berghei ANKA." Evidence-Based Complementary and Alternative Medicine 2022 (July 30, 2022): 1–11. http://dx.doi.org/10.1155/2022/2640648.

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Background. Drug resistance is a universal challenge to malaria control measures. As a result, the development and discovery of new chemotherapeutic agents from medicinal plants having anti-malarial traditional claims are very important. This work, therefore, attempted to evaluate the anti-malarial activity of the aqueous root extract of E. divinorum using a rodent model of malaria. Methods. The roots of E. divinorum were extracted by hot decoction using distilled water. Anti-malarial activity of various doses (100 mg/kg, 200 mg/kg, and 600 mg/kg) of the root aqueous extract was evaluated usin

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Sahli, Indra Taufik, Asrianto Asrianto, Fajar Bakti Kurniawan, Risda Hartati, and Dwi Setiani. "Tingkat Parasitemia Penderita Malaria Berdasarkan Golongan Darah ABO di Kota Jayapura." Jurnal Kesehatan Metro Sai Wawai 14, no. 2 (2021): 104–11. http://dx.doi.org/10.26630/jkm.v14i2.2940.

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Background: Malaria is the world's leading parasitic infectious disease caused by protozoa of the genus Plasmodium. An association between ABO blood type and malaria infection has been reported, but the results are conflicting. Purpose: This study aims to determine the level of parasitemia in malaria patients based on ABO blood type. Methods: This research is an analytic study with a cross-sectional design. The variables studied were the ABO blood group and the level of parasitemia. The number of samples in this study was 63 samples. Results: The results of the study from 63 samples showed tha

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Park, Sangshin, Christina E. Nixon, Olivia Miller, et al. "Impact of Malaria in Pregnancy on Risk of Malaria in Young Children: Systematic Review and Meta-Analyses." Journal of Infectious Diseases 222, no. 4 (2020): 538–50. http://dx.doi.org/10.1093/infdis/jiaa139.

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Abstract Background Our objective was to quantify the risk of acquiring malaria among progeny of women with malaria during pregnancy. Methods We searched MEDLINE, EMBASE, CINAHL, and the Cochrane Library for eligible prospective studies. The primary predictor was malaria during pregnancy defined as placental malaria, parasitemia, clinical malaria, or pregnancy-associated malaria. Primary outcomes were parasitemia or clinically defined malaria of young children. We performed meta-analyses to pool adjusted risk estimates using a random-effects model. Results Nineteen of 2053 eligible studies met

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Chin, Voon Kin, Chong WC, Haniza H, and Rusliza Basir. "MODULATING EFFECTS OF IL-4, IL-10 AND IL-13 ON THE COURSE OF PLASMODIUM BERGHEI MALARIA INFECTION IN MICE." Journal of Health and Translational Medicine 24, no. 2 (2021): 92–105. http://dx.doi.org/10.22452/jummec.vol24no2.13.

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Background: Inflammation is a crucial process driving pathogenesis in malaria infection. The devastating effects of malaria infection has always been associated with severe inflammation whilst protective effect is linked to provocation of anti-inflammation responses. IL-4, IL-10 and IL-13 are well-established anti-inflammatory cytokines with their functional roles during malaria infection remain elusive. Therefore, this study was undertaken to study the effects of modulating IL-10, IL-4 and IL-13 on the course of malaria infection in Plasmodium berghei ANKA (PbA)-infected murine model. Methods

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Ezeokoli, Emmanuel Ozioma, Grace Ifechukwudelu Amilo, E. Chukwuemeka O. Izuchukwu, et al. "Evaluation of Plasma Levels of Interferon-Gamma, Interleukin-6, and Transforming Growth Factor-Beta in Under-Five Children with Malaria Parasitaemia." South East European Journal of Immunology 6, no. 1 (2023): 50–55. http://dx.doi.org/10.3889/seejim.2023.6042.

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BACKGROUND: The interaction between the pro- and anti-inflammatory cytokines is known to play key roles in the immune response to infectious diseases. The pathogenesis of malaria parasitemia, including its progression to symptomatic manifestation, also seems to be strongly related to this interplay. AIM: The study evaluated the plasma levels of interferon-gamma (IFN-γ) and interleukin-6 (IL)-6, which are pro- inflammatory cytokines, and transforming growth factor-beta (TGF-β), which is an anti-inflammatory cytokine; in the 6–60 months age-group children, when infected with Plasmodium falciparu

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Eisen, Rebecca J. "Variation in life-history traits of Plasmodium mexicanum, a malaria parasite infecting western fence lizards: a longitudinal study." Canadian Journal of Zoology 78, no. 7 (2000): 1230–37. http://dx.doi.org/10.1139/z00-057.

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The life history of malaria parasites (Plasmodium spp.) is directly related to their transmission, virulence, and population dynamics. I followed the life history of Plasmodium mexicanum in naturally infected western fence lizards (Sceloporus occidentalis) over a 4-year period, using a mark-recapture technique. The life-history traits measured included peak parasitemias and population growth rates of asexual forms, gametocytes, and total parasites. Among malaria infections, variation was high for all measured traits. Growth rates varied up to 11-fold, and among stable infections, average asexu

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Yoon, Jung, Woong Sik Jang, Jeonghun Nam, Do-CiC Mihn, and Chae Seung Lim. "An Automated Microscopic Malaria Parasite Detection System Using Digital Image Analysis." Diagnostics 11, no. 3 (2021): 527. http://dx.doi.org/10.3390/diagnostics11030527.

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Rapid diagnosis and parasitemia measurement is crucial for management of malaria. Microscopic examination of peripheral blood (PB) smears is the gold standard for malaria detection. However, this method is labor-intensive. Here, we aimed to develop a completely automated microscopic system for malaria detection and parasitemia measurement. The automated system comprises a microscope, plastic chip, fluorescent dye, and an image analysis program. Analytical performance was evaluated regarding linearity, precision, and limit of detection and was compared with that of conventional microscopic PB s

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Ayede, Adejumoke, Banke Amoo, John Anetor, and Adesegun Adeola. "Status of Some Basic Antioxidants in Pre- and Postmalaria Treatment in Children." Journal of Child Science 08, no. 01 (2018): e31-e35. http://dx.doi.org/10.1055/s-0038-1642065.

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Malaria is the most common tropical disease to which infants and children are the most susceptible. It is caused by Plasmodium species and is associated with oxidative stress, which has an effect on body antioxidants. The relationship between the degree of parasitemia and copper (Cu), zinc (Zn), and uric acid was evaluated in this study.Seventy children (mean age: 7.80 ± 0.38 years) microscopically diagnosed positive for malaria parasite were selected. Fifty-six apparently healthy children (mean age: 6.68 ± 0.48 years) served as the control group. The malaria group was classified into pretreat

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Branco, Ana, and José Melo-Cristino. "Extreme parasitemia in P falciparum malaria." Blood 132, no. 8 (2018): 868. http://dx.doi.org/10.1182/blood-2018-07-861880.

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Nwaka, C. A., T. U. Maduoma, O. N. Oni-adimabua, et al. "Evaluation of Bone Marrow Response in Different Degrees of Malaria Parasitemia in Children." Journal of Applied Sciences and Environmental Management 29, no. 5 (2025): 1462–71. https://doi.org/10.4314/jasem.v29i5.10.

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Malaria remains a significant public health concern, particularly in endemic regions, where it poses a severe risk to children and can lead to increased morbidity and mortality. Hence, the objective of this paper is to evaluate the haematological parameters and reticulocyte counts in children in fifty (50) children aged 5 to 12 years with various malaria parasitemia attending a tertiary teaching hospital at Elele, Rivers State, Nigeria using appropriate standard techniques. The study revealed a significant increase in mean reticulocyte counts in the test group (3.1 ± 1.12%) compared to the con

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