Academic literature on the topic 'Malaria – Pathogenesis'

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Journal articles on the topic "Malaria – Pathogenesis"

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Milner, Danny A. "Malaria Pathogenesis." Cold Spring Harbor Perspectives in Medicine 8, no. 1 (May 22, 2017): a025569. http://dx.doi.org/10.1101/cshperspect.a025569.

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Miller, L., M. Good, and G. Milon. "Malaria pathogenesis." Science 264, no. 5167 (June 24, 1994): 1878–83. http://dx.doi.org/10.1126/science.8009217.

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Amoako-Sakyi, Daniel, Selorme Adukpo, Kwadwo A. Kusi, Daniel Dodoo, Michael F. Ofori, George O. Adjei, Dominic E. Edoh, et al. "A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children." Genetics & Epigenetics 8 (January 2016): GEG.S38307. http://dx.doi.org/10.4137/geg.s38307.

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Malaria pathogenesis may be influenced by IgE responses and cytokine cross-regulation. Several mutations in the IL-4/STAT6 signaling pathway can alter cytokine cross-regulation and IgE responses during a Plasmodium falciparum malarial infection. This study investigated the relationship between a STAT6 intronic single-nucleotide polymorphism (rs3024974), total IgE, cytokines, and malaria severity in 238 Ghanaian children aged between 0.5 and 13 years. Total IgE and cytokine levels were measured by ELISA, while genotyping was done by polymerase chain reaction-restriction fragment length polymorp
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John, Chandy C. "Cerebral Malaria Pathogenesis." American Journal of Pathology 171, no. 6 (December 2007): 1729–32. http://dx.doi.org/10.2353/ajpath.2007.070917.

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Clark, I. A., and L. Schofield. "Pathogenesis of Malaria." Parasitology Today 16, no. 10 (October 2000): 451–54. http://dx.doi.org/10.1016/s0169-4758(00)01757-9.

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Mideo, Nicole, Troy Day, and Andrew F. Read. "Modelling malaria pathogenesis." Cellular Microbiology 10, no. 10 (October 2008): 1947–55. http://dx.doi.org/10.1111/j.1462-5822.2008.01208.x.

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O’Sullivan, Jamie M., and James S. O’Donnell. "Platelets in malaria pathogenesis." Blood 132, no. 12 (September 20, 2018): 1222–24. http://dx.doi.org/10.1182/blood-2018-08-865618.

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Dasari, Prasad, and Sucharit Bhakdi. "Pathogenesis of malaria revisited." Medical Microbiology and Immunology 201, no. 4 (September 7, 2012): 599–604. http://dx.doi.org/10.1007/s00430-012-0265-y.

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Meshnick, Steven R., and Stephen J. Rogerson. "Pathogenesis of malaria in pregnancy." Microbiology Australia 29, no. 4 (2008): 204. http://dx.doi.org/10.1071/ma08204.

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Even though we have good tools to prevent and treat malaria, it remains a tragically common disease in poor countries, especially in Africa. Pregnant women are particularly susceptible to malaria, causing anaemia and poor birth outcomes. There is marked sequestration of Plasmodium falciparum-infected erythrocytes (IEs) in the placenta, but the pathogenesis of malaria in pregnancy is still incompletely understood. Both intermittent preventive therapy and insecticide-impregnated bed nets are effective protective measures, but new measures are also needed.
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Moxon, Christopher A., Matthew P. Gibbins, Dagmara McGuinness, Danny A. Milner, and Matthias Marti. "New Insights into Malaria Pathogenesis." Annual Review of Pathology: Mechanisms of Disease 15, no. 1 (January 24, 2020): 315–43. http://dx.doi.org/10.1146/annurev-pathmechdis-012419-032640.

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Malaria remains a major public health threat in tropical and subtropical regions across the world. Even though less than 1% of malaria infections are fatal, this leads to about 430,000 deaths per year, predominantly in young children in sub-Saharan Africa. Therefore, it is imperative to understand why a subset of infected individuals develop severe syndromes and some of them die and what differentiates these cases from the majority that recovers. Here, we discuss progress made during the past decade in our understanding of malaria pathogenesis, focusing on the major human parasite Plasmodium f
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Dissertations / Theses on the topic "Malaria – Pathogenesis"

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Herricks, Thurston E. "Malaria pathogenesis : deformability limits of malaria infected erythrocytes /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8622.

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Chang, Kai-Hsin 1974. "Erythropoietin, erythropoiesis, and malarial anemia : the mechanisms and implications of insufficient erythropoiesis during murine blood-stage malaria." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84490.

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Severe anemia is a major life-threatening complication of malaria. Inappropriately low reticulocytosis in malaria patients with anemia suggests insufficient erythropoiesis, of which the mechanisms and implications are not clear. The principle growth factor that promotes erythropoiesis is erythropoietin (Epo). Studies determining the serum level of Epo in malaria infected patients have been inconclusive. Furthermore, the role of Epo and the erythropoietic response to Epo stimulation during malaria have never been examined. The purpose of the experiments performed in this thesis was, thus
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Okrinya, Aniayam. "Mathematical modelling of malaria transmission and pathogenesis." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/17160.

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In this thesis we will consider two mathematical models on malaria transmission and patho- genesis. The transmission model is a human-mosquito interaction model that describes the development of malaria in a human population. It accounts for the various phases of the disease in humans and mosquitoes, together with treatment of both sick and partially im- mune humans. The partially immune humans (termed asymptomatic) have recovered from the worst of the symptoms, but can still transmit the disease. We will present a mathematical model consisting of a system of ordinary differential equations th
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Weiser, Silvia. "In vitro studies on the pathogenesis of cerebral malaria." Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28140.

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Malaria is caused by infection with the protozoan Plasmodium. About 40% of the world’s population is at risk, nearly all of them living in the least developed countries. While 300-500 million cases are reported per year, about 2 million people die annually. Most of the fatal cases develop severe malaria, which is a complication of Plasmodium fulciparum infection. Symptoms can include multi-organ dysfunction, anaemia, lung complications and cerebral malaria (CM). Although the pathogenesis is controversial, there are two main theories to explain the aetiology of CM: sequestration of parasi
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Knackstedt, Sebastian Lorenz. "Neutrophil extracellular traps drive inflammatory pathogenesis in malaria." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/19767.

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Malaria ist die Erkrankung, die durch Infektion eines Säugetiers mit dem eukaryotischen Parasiten Plasmodium entsteht. Die Symptome dieser Erkrankungen reichen von Fieber und Gelenkschmerzen bis zu schweren Organschäden in Hirn, Lunge, Niere und Leber bei einem geringen Teil der Erkrankten. Diese klinischen Symptome treten nur auf, während der Parasit sich asexuell in roten Blutzellen vermehrt. Die Zerstörung von Erythrozyten und die daraus resultierende Freisetzung von Zytokinen sind die Verursacher der malariatypischen wiederkehrenden Fieberzyklen. Der Mechanismus, der zur Entstehung von Gew
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Bakmiwewa, Supun Madushani. "The Astrocyte: a Crossroads in Cerebral Malaria Pathogenesis." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14952.

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Cerebral malaria (CM) is a severe complication of malaria, and involves the central nervous system (CNS). Despite the significant negative impact of CM, its pathogenesis is not fully understood. Two theories, namely cerebral hypoxia and cytokine expression, are considered to be involved in the process. The present study investigated the potential interaction of these two theories in driving the development of CM. Astrocytes can be a major determinant of the outcome of CNS diseases, and we hypothesised that astrocytes, by responding to the pathways involved in the two theories, would drive the
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Contreras, Ana Paulina. "Modulation of macrophage nitric oxide production by hemozoin." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100786.

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Malaria is one of the most serious human infectious diseases. To date, the collection of studies suggest that the disease is determined by transmission dynamics and host age altogether with host genetics and immunological responses. The precise and direct contribution of parasite components to the activation of such immunological responses has not been fully unravelled. In addition to a role proposed for plasmodial GPI, different lines of evidence suggest that hemozoin (HZ) could also be a potential inflammatory agent. The role of HZ in the modulation of immune responses has remained a polemic
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Cohen, Amy. "Cellular, subcellular, and molecular elements of cerebral malaria pathogenesis." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18112.

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A complex network of elements is responsible for cerebral malaria (CM) development, but interactions between these elements are still being explored. Annually, there are 212 million cases of malaria with 1-2% progressing to CM. Plasma microvesicles (MV) are increased in patients and mice with CM and blocking their release protects against CM. The miRNA content of circulating plasma MV and brain tissue during murine CM and non-CM was assessed using microarray and RT-qPCR techniques. Following infection, MV and brain miRNA were altered in CM mice, coinciding with neurological syndrome onset. Par
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Nunes, da Silva Ana Sofia. "Characterization of the molecular mechanisms involved in severe malaria pathogenesis." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC065.

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L'importante virulence de P. Falciparum a été reliée à la capacité du parasite à adhérer aux cellules endothéliales de la microvasculature ou aux syncytiotrophoblastes placentaires. La séquestration de globules rouges infectés dans différents organes conduit à l'apparition des symptômes cliniques de la maladie. Les protéines variables PfEMP1, exprimées à la surface des hématies parasitées, sont les ligands parasitaires majeurs responsables de la cytoadhérence. PfEMP1-VAR2CSA est le candidat vaccinal le plus prometteur pour lutter contre le paludisme gestationnel. Afin de mieux caractériser les
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Ariyoshi, Koya. "The role of viral load in the pathogenesis of HIV-2 infection." Thesis, Open University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262968.

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Books on the topic "Malaria – Pathogenesis"

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Peterson, Anna Margrét, and Gerald E. Calamandrei. Malaria: Etiology, pathogenesis, and treatments. New York: Nova Science Publishers, 2011.

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Stoute, José A., ed. Complement Activation in Malaria Immunity and Pathogenesis. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-77258-5.

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P, Waters Andrew, and Janse Chris J, eds. Malaria parasites, genomes and molecular biology. Wymondham, Norfolk, England: Caister Academic Press, 2004.

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1941-, Eaton John Wallace, Meshnick Steven R, and Brewer George J. 1930-, eds. Malaria and the red cell 2: Proceedings of the Second Workshop on Malaria and the Red Cell, held in Ann Arbor, Michigan, October 24, 1988. New York: A.R. Liss, 1989.

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Kelty, Christopher M. Ebola's ecologies. California]: Creative Commons, 2015.

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Tsuyoshi, Ishii, Allsop David, Selkoe Dennis J, and International Congress of Neuropathology (11th : 1990 : Kyoto, Japan), eds. Frontiers of Alzheimer research: Proceedings of the 5th International Symposium of the Psychiatric Research Institute of Tokyo (PRIT), Tokyo, 10-12 September 1990. Amsterdam: Excerpta Medica, 1991.

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Khalid, Iqbal, and International Conference on Alzheimer's Disease and Related Disorders (4th : 1994 : Minneapolis, Minn.), eds. Research advances in Alzheimer's disease and related disorders. Chichester: Wiley, 1995.

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Lester, Packer, Prilipko L. 1945-, and Christen Yves, eds. Free radicals in the brain: Aging, neurological, and mental disorders. Berlin: Springer-Verlag, 1992.

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J, Epstein Charles, Nadel Lynn, and National Down Syndrome Society (U.S.), eds. Down syndrome and Alzheimer disease: Proceedings of the National Down Syndrome Society Conference on Down Syndrome and Alzheimer Disease, held in New York, January 16 and 17, 1992. New York: Wiley-Liss, 1992.

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Uehara Memorial Foundation Symposium on Common Disease (1999 Tokyo). Common disease: Genetic and pathogenetic aspects of multifactorial diseases, proceedings of the Uehara Memorial Foundation Symposium on Common Disease, Tokyo on June 30-July 2, 1999. Edited by Imura Hiroo, Kasuga Masato, and Nakao Kazuwa 1948-. Amsterdam: Elsevier Science B.V., 1999.

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Book chapters on the topic "Malaria – Pathogenesis"

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Gonçalves, Bronner P., Michal Fried, and Patrick E. Duffy. "Malaria pathogenesis." In Advances in Malaria Research, 427–64. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2016. http://dx.doi.org/10.1002/9781118493816.ch16.

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Ferluga, Janez, Iesha Singh, Sashmita Rout, Ahmed Al-Qahtani, Hadida Yasmin, and Uday Kishore. "Immune Responses in Malaria and Vaccine Strategies." In Microbial Pathogenesis, 273–91. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-67452-6_12.

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Amaratunga, Chanaki, Tatiana M. Lopera-Mesa, Jeanette G. Tse, Neida K. Mita-Mendoza, and Rick M. Fairhurst. "Pathology and Pathogenesis of Malaria." In The Immune Response to Infection, 361–81. Washington, DC, USA: ASM Press, 2014. http://dx.doi.org/10.1128/9781555816872.ch29.

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Weckman, Andrea, Vanessa Tran, and Kevin C. Kain. "Complement and Malaria in Pregnancy." In Complement Activation in Malaria Immunity and Pathogenesis, 91–105. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-77258-5_5.

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Grau, Georges Emile Raymond, and Nicholas Henry Hunt. "Cytokines and Some of Their Effector Mechanisms in Cerebral Malaria Pathogenesis." In Encyclopedia of Malaria, 1–11. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4614-8757-9_94-1.

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Taylor, Ronald P., José A. Stoute, and Margaret A. Lindorfer. "Mechanisms of Complement Activation in Malaria." In Complement Activation in Malaria Immunity and Pathogenesis, 31–49. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-77258-5_2.

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Schein, Theresa N., and Scott R. Barnum. "Role of Complement in Cerebral Malaria." In Complement Activation in Malaria Immunity and Pathogenesis, 65–90. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-77258-5_4.

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Stoute, José A. "Role of Complement in Immunity Against Malaria." In Complement Activation in Malaria Immunity and Pathogenesis, 125–37. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-77258-5_7.

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Biryukov, Sergei, and José A. Stoute. "The Complement System." In Complement Activation in Malaria Immunity and Pathogenesis, 1–29. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-77258-5_1.

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Stoute, José A. "Role of Complement in Severe Malarial Anemia." In Complement Activation in Malaria Immunity and Pathogenesis, 51–64. Cham: Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-77258-5_3.

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Conference papers on the topic "Malaria – Pathogenesis"

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Meissner, PeterE. "Malaria – Pathogenese, Klinik und Therapie." In 8. Symposium HÄMATOLOGIE HEUTE. Georg Thieme Verlag, 2022. http://dx.doi.org/10.1055/s-0042-1744089.

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Younis, Khansa Mohammed, Gires Usup, and Asmat Ahmad. "A prospective study on evaluation of pathogenesis, biofilm formation, antibiotic susceptibility of microbial community in urinary catheter." In THE 2015 UKM FST POSTGRADUATE COLLOQUIUM: Proceedings of the Universiti Kebangsaan Malaysia, Faculty of Science and Technology 2015 Postgraduate Colloquium. AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4931227.

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Reports on the topic "Malaria – Pathogenesis"

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Oakley, Miranda S. Molecular Factors and Biological Pathways Associated with Malaria Fever and the Pathogenesis of Cerebral Malaria. Fort Belvoir, VA: Defense Technical Information Center, March 2007. http://dx.doi.org/10.21236/ad1014029.

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