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Dissertations / Theses on the topic 'Malaria – Pathogenesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 September 2023

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1

Herricks, Thurston E. "Malaria pathogenesis : deformability limits of malaria infected erythrocytes /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/8622.

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2

Chang, Kai-Hsin 1974. "Erythropoietin, erythropoiesis, and malarial anemia : the mechanisms and implications of insufficient erythropoiesis during murine blood-stage malaria." Thesis, McGill University, 2003. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84490.

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Severe anemia is a major life-threatening complication of malaria. Inappropriately low reticulocytosis in malaria patients with anemia suggests insufficient erythropoiesis, of which the mechanisms and implications are not clear. The principle growth factor that promotes erythropoiesis is erythropoietin (Epo). Studies determining the serum level of Epo in malaria infected patients have been inconclusive. Furthermore, the role of Epo and the erythropoietic response to Epo stimulation during malaria have never been examined. The purpose of the experiments performed in this thesis was, thus

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3

Okrinya, Aniayam. "Mathematical modelling of malaria transmission and pathogenesis." Thesis, Loughborough University, 2015. https://dspace.lboro.ac.uk/2134/17160.

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In this thesis we will consider two mathematical models on malaria transmission and patho- genesis. The transmission model is a human-mosquito interaction model that describes the development of malaria in a human population. It accounts for the various phases of the disease in humans and mosquitoes, together with treatment of both sick and partially im- mune humans. The partially immune humans (termed asymptomatic) have recovered from the worst of the symptoms, but can still transmit the disease. We will present a mathematical model consisting of a system of ordinary differential equations th

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4

Weiser, Silvia. "In vitro studies on the pathogenesis of cerebral malaria." Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28140.

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Malaria is caused by infection with the protozoan Plasmodium. About 40% of the world’s population is at risk, nearly all of them living in the least developed countries. While 300-500 million cases are reported per year, about 2 million people die annually. Most of the fatal cases develop severe malaria, which is a complication of Plasmodium fulciparum infection. Symptoms can include multi-organ dysfunction, anaemia, lung complications and cerebral malaria (CM). Although the pathogenesis is controversial, there are two main theories to explain the aetiology of CM: sequestration of parasi

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5

Knackstedt, Sebastian Lorenz. "Neutrophil extracellular traps drive inflammatory pathogenesis in malaria." Doctoral thesis, Humboldt-Universität zu Berlin, 2019. http://dx.doi.org/10.18452/19767.

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Malaria ist die Erkrankung, die durch Infektion eines Säugetiers mit dem eukaryotischen Parasiten Plasmodium entsteht. Die Symptome dieser Erkrankungen reichen von Fieber und Gelenkschmerzen bis zu schweren Organschäden in Hirn, Lunge, Niere und Leber bei einem geringen Teil der Erkrankten. Diese klinischen Symptome treten nur auf, während der Parasit sich asexuell in roten Blutzellen vermehrt. Die Zerstörung von Erythrozyten und die daraus resultierende Freisetzung von Zytokinen sind die Verursacher der malariatypischen wiederkehrenden Fieberzyklen. Der Mechanismus, der zur Entstehung von Gew

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6

Bakmiwewa, Supun Madushani. "The Astrocyte: a Crossroads in Cerebral Malaria Pathogenesis." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14952.

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Cerebral malaria (CM) is a severe complication of malaria, and involves the central nervous system (CNS). Despite the significant negative impact of CM, its pathogenesis is not fully understood. Two theories, namely cerebral hypoxia and cytokine expression, are considered to be involved in the process. The present study investigated the potential interaction of these two theories in driving the development of CM. Astrocytes can be a major determinant of the outcome of CNS diseases, and we hypothesised that astrocytes, by responding to the pathways involved in the two theories, would drive the

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7

Contreras, Ana Paulina. "Modulation of macrophage nitric oxide production by hemozoin." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=100786.

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Malaria is one of the most serious human infectious diseases. To date, the collection of studies suggest that the disease is determined by transmission dynamics and host age altogether with host genetics and immunological responses. The precise and direct contribution of parasite components to the activation of such immunological responses has not been fully unravelled. In addition to a role proposed for plasmodial GPI, different lines of evidence suggest that hemozoin (HZ) could also be a potential inflammatory agent. The role of HZ in the modulation of immune responses has remained a polemic

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8

Cohen, Amy. "Cellular, subcellular, and molecular elements of cerebral malaria pathogenesis." Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/18112.

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A complex network of elements is responsible for cerebral malaria (CM) development, but interactions between these elements are still being explored. Annually, there are 212 million cases of malaria with 1-2% progressing to CM. Plasma microvesicles (MV) are increased in patients and mice with CM and blocking their release protects against CM. The miRNA content of circulating plasma MV and brain tissue during murine CM and non-CM was assessed using microarray and RT-qPCR techniques. Following infection, MV and brain miRNA were altered in CM mice, coinciding with neurological syndrome onset. Par

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9

Nunes, da Silva Ana Sofia. "Characterization of the molecular mechanisms involved in severe malaria pathogenesis." Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCC065.

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L'importante virulence de P. Falciparum a été reliée à la capacité du parasite à adhérer aux cellules endothéliales de la microvasculature ou aux syncytiotrophoblastes placentaires. La séquestration de globules rouges infectés dans différents organes conduit à l'apparition des symptômes cliniques de la maladie. Les protéines variables PfEMP1, exprimées à la surface des hématies parasitées, sont les ligands parasitaires majeurs responsables de la cytoadhérence. PfEMP1-VAR2CSA est le candidat vaccinal le plus prometteur pour lutter contre le paludisme gestationnel. Afin de mieux caractériser les

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10

Ariyoshi, Koya. "The role of viral load in the pathogenesis of HIV-2 infection." Thesis, Open University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262968.

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11

Esamai, Fabian. "Cerebral malaria in children in the highlands of Kenya : aspects of pathogenesis and clinical presentation /." Linköping : Univ, 2002. http://www.bibl.liu.se/liupubl/disp/disp2002/med729s.pdf.

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12

Srinivasan, Prakash. "The Role of Rhomboid proteases and a Oocyst Capsule protein in Malaria Pathogenesis and Parasite Development." Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1181352186.

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13

Donati, Daria. "Malaria, B lymphocytes and Epstein-Barr virus : emerging concepts on Burkitt's lymphoma pathogenesis /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-403-1/.

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14

D'Alessandro, S. "Role of endothelial cells in severe malaria pathogenesis: effects of parasites and antimalarial drugs." Doctoral thesis, Università degli Studi di Milano, 2010. http://hdl.handle.net/2434/167234.

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Endothelium plays a crucial role in the regulation of vascular homeostasis and permeability. Its adhesion proprieties are highly regulated to allow physiologic functions, such as the migration of leucocytes into tissue, and to avoid pathologic degenerations. In particular, the adhesion of red blood cells (RBC) to endothelial cells (ECs) is involved in pathologies such as sickle cell anaemia, diabetes and malaria. In severe malaria RBC infected with Plasmodium falciparum (Pf) undergo membrane alterations which cause a receptor-mediated adhesion to endothelium. This phenomenon is called cytoadh

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15

Maude, Richard James. "Retinopathy and central nervous system microcirculatory abnormalities in adult cerebral malaria and their prediction of outcome." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/22807.

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Introduction Malaria retinopathy is a set of visible changes in the retina which are specific to falciparum malaria. Studies to date have been mostly limited to comatose African children. Retinal changes in adults with severe malaria and severely unwell patients without malaria have been less well studied and the specificity, pathogenesis, diagnostic and prognostic value of malarial retinopathy in adults are not known. Methods A series of observational studies of retinopathy in Bangladesh, India and Malaysia were done from 2008-2012. The aims were to describe the spectrum of retinal changes in

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16

Thomas, Phaedra J. "A Forward Genetic Screen Identifies Factors Associated with Fever Pathogenesis in Plasmodium falciparum." Scholar Commons, 2015. http://scholarcommons.usf.edu/etd/5785.

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Infectious diseases that spread from person-to-person and continent-to-continent are a cause for concern for any health entity. One such disease is malaria, a mosquito-borne infection instigated by the protozoan parasite, Plasmodium falciparum. Hundreds of millions of people are affected annually and it is responsible for nearly 1 million deaths. It is the most fatal species causing malaria and proliferates in human red blood cells with a life cycle occurring every 48 hours. At this time, the parasite’s late stage form or schizont bursts from the erythrocyte releasing immune-inducing particles

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17

Hackett, Sara. "Magneto-chemical speciation of pathogenic iron deposits in thalassaemia and malaria." University of Western Australia. School of Physics, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0205.

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[Truncated abstract] Iron is essential to most biological systems. Under pathological conditions affecting the iron metabolic pathway, iron can be deposited in the tissue in various forms. The work presented in this thesis has exploited the relationship between the magnetic and the chemical properties of tissue iron deposits to further understanding of two major pathologies, the haemoglobinopathies termed thalassaemias and the malaria parasite Plasmodium falciparum, both amongst the most common health concerns in tropical countries. The iron-specific magnetic susceptibilities ¿Fe for spleen ti

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18

Alkaitis, Matthew S. "Biochemical determinants of nitric oxide synthesis in severe malaria." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:dde50b9c-fea1-432a-8c5f-35e97e641061.

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Inhibition of nitric oxide (NO) signalling may contribute to the pathogenesis of severe malaria. This thesis examines the impact of Plasmodium infection on three key determinants of nitric oxide synthase (NOS) biochemistry: substrate availability, substrate/inhibitor homeostasis and cofactor availability. Arginine, the NOS substrate, is depleted in human patients with severe Plasmodium falciparum malaria and mice infected with P. berghei ANKA. Using heavy isotope tracer infusions to quantify arginine metabolism in infected mice, we found no evidence of increased catabolism by the enzyme argina

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19

Scaccabarozzi, D. "THE PATHOGENESIS OF MALARIA ACUTE RESPIRATORY DISTRESS SYNDROME (MA-ARDS): MODIFICATION OF THE LIPID PROFILE, ANTIOXIDANT DEFENCES AND CYTOKINE CONTENT IN DIFFERENT TISSUES OF MALARIA INFECTED MICE." Doctoral thesis, Università degli Studi di Milano, 2014. http://hdl.handle.net/2434/231156.

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INTRODUCTION Malaria is a major health problem, with more than 650.000 deaths and 200 million clinical cases each year. Respiratory distress as malaria associated acute respiratory distress syndrome (MA-ARDS) is a common complication. The pathogenesis of MA-ARDS is mainly inflammatory and one of the main observation is the presence of abundant monocytes and macrophages inside the blood capillaries, in the interstitium and also in alveolar spaces. Malaria pigment or haemozoin (Hz) is often seen in these cells reflecting active phagocytosis and leads to the production of cytokines and other infl

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20

Knackstedt, Sebastian Lorenz [Verfasser], Arturo [Gutachter] Zychlinsky, Simone [Gutachter] Reber, and Elena [Gutachter] Levashina. "Neutrophil extracellular traps drive inflammatory pathogenesis in malaria / Sebastian Lorenz Knackstedt ; Gutachter: Arturo Zychlinsky, Simone Reber, Elena Levashina." Berlin : Humboldt-Universität zu Berlin, 2019. http://d-nb.info/1182542107/34.

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21

Carter, Julie Ann. "Epilepsy and developmental impairments following severe malaria in Kenyan children : a study of their prevalence, relationships, clues to pathogenesis and service requirements." Thesis, University College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404806.

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22

Stubberfield, Lisa Marie. "Interactions of Plasmodium falciparum proteins at the membrane skeleton of infected erythrocytes." Monash University, Dept. of Microbiology, 2003. http://arrow.monash.edu.au/hdl/1959.1/9433.

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23

Boutajangout, Allal. "Pathogénie des dégénérescences neurofibrillaires de la maladie d'Alzheimer." Doctoral thesis, Universite Libre de Bruxelles, 2005. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210900.

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La maladie d’Alzheimer (MA) est caractérisée par deux lésions neuropathologiques: les plaques séniles (composées essentiellement du peptide amyloïde Ab) et les dégénérescences neurofibrillaires (DNF, composées de formes hyperphosphorylées de protéines tau). Les mécanismes de formation des DNF sont encore mal compris et notre travail expérimental a eu pour objectifs d’étudier certaines hypothèses de formation des DNF.<p>1° Une hypothèse étiopathogénique de la MA est la “cascade amyloïde”, selon laquelle le peptide amyloïde Ab exercerait un effet toxique entraînant la phosphorylation de tau et l

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24

Couderc, Thérèse. "Aspects de la pathogenese moleculaire d'une maladie connue depuis l'antiquite : la polyomyelite paralytique." Paris 7, 1990. http://www.theses.fr/1990PA077123.

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Depuis les annees 60, peu de travaux sur la pathogenese de la poliomyelite ont ete publies. Afin de donner un eclairage nouveau aux donnees moleculaires sur la neurovirulence du poliovirus, nous avons tente de definir le mode de propagation de ce virus in vivo. Dans le but d'identifier les cellules siege de la multiplication extraneurale a l'origine de la viremie persistante, nous avons teste l'hypothese des cellules endotheliales source de cette viremie. L'etude de la permissivite des cellules endotheliales in vitro au poliovirus a montre qu'un faible pourcentage de cellules sont sensibles a

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25

di, Domenico Angelique. "Investigating Glial Contributions During Parkinson’s Disease Pathogenesis Using Patient-Specific iPSC-Derived Cells." Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/462955.

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La malaltia de Parkinson (PD) s'associa amb la degeneració de les neurones dopaminèrgiques del mesencèfal ventral (vmDA) i l'acumulació d'inclusions citoplasmàtiques, els cossos de Lewy, compostos principalment per la α sinucleina agregada en les neurones vmDA supervivents. Aquest procés, juntament amb els mecanismes patogènics autònoms cel·lulars subjacents, s'ha modelat fins ara amb èxit utilitzant tecnologia de cèl·lules mare pluripotents induïdes de cada pacient (iPSC). En el nostre laboratori, vam generar astròcits de línies d'iPSC derivades de pacients amb PD familiar amb la mutació G20

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26

Sun, Jun. "Study of neuronal networks and mechanisms implicated in locomotor reactivity and Parkinson's disease pathogenesis in the Drosophila model." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS434.

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La maladie de Parkinson (MP) est un trouble moteur neurodégénératif progressif, caractérisé par la perte des neurones dopaminergiques (DA) de la substance noire et la présence d'inclusions cytoplasmiques composées principalement de synucléine α (syn α), appelées corps de Lewy. Les objectifs de mon travail de thèse étaient de caractériser un modèle de la MP développé chez la drosophile afin de comprendre comment l'accumulation de syn α dans les neurones DA peut perturber progressivement la locomotion et de rechercher de nouvelles protéines neuroprotectrices. Nous avons d'abord identifié des rés

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27

Virreira, Bermudez Myrna. "DNA polymorphism in congenital infection of Trypanosoma cruzi: diagnostic and epidemiological interest." Doctoral thesis, Universite Libre de Bruxelles, 2007. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210582.

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28

PICCININI, SIMONA. "Involvement of Gut Immune System in the pathogenesis of type 1 diabetes: detection of T cell reactivity to Gliadin." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/558.

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Diversi studi sperimentali hanno evidenziato un possibile ruolo del sistema immune intestinale nella patogenesi del diabete di tipo 1(T1D). Lo scopo del nostro studio è stato quello di evidenziare un possibile link tra il sistema immune intestinale e il T1D, in particolare un possibile ruolo del glutine come antigene T cellulare nel T1D. Le cellule mononucleate del sangue periferico (PBMC) sono state isolate da 25 bambini con T1D (età da 3.4 a 19.6 anni), da 22 controlli sani (HC) (età da 3.5 a 17 anni) entrambi negativi per gli anticorpi antiendomisio e anti-transglutaminasi e da 15 bambini

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Fernández, Carasa Irene. "Investigating the role of mitochondrial dysfunction in the pathogenesis of Parkinsons´s disease using patient-specific derived astrocytes." Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673716.

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Parkinson’s disease (PD) is an incurable, chronically progressive disorder of old age leading to premature invalidity and death. Clinically, PD is characterized by classical motor syndrome linked to a progressive loss of dopamine-containing neurons (DAn) in the substantia nigra pars compacta, and disabling non-motor symptoms related to extranigral lesions. The identification of several genes associated to familiar PD have brought considerable insight into underlying pathogenic mechanisms. However, the unknown etiology of the sporadic forms (90% of patients) and the emerging view that non-neur

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Tang, Jun. "The tumor microenvironment in lung cancer pathogenesis: A hint to therapeutic agents and the influence of chronic obstructive pulmonary disease." Doctoral thesis, Universitat Autònoma de Barcelona, 2021. http://hdl.handle.net/10803/672510.

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Introducció: La malaltia pulmonar obstructiva crònica (MPOC) és un factor de risc independent per el desenvolupament de càncer de pulmó (CP) en els pacients. Els mecanismes encara s’han de dilucidar per a comprendre les relacions entre MPOC i CP. Hipòtesi: Els components del microambient tumoral poden diferir en els tumors de pacients amb CP amb i sense MPOC. La immunoteràpia també pot reduir la càrrega tumoral a través de diversos mecanismes biològics. Objectius: 1) Pacients: estudiar el paper del microambient tumoral, les cèl·lules immunitàries, les característiques de l’estroma i la s

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31

Orlewski, Piotr. "Modélisation des interactions anticorps-antigène : application à une maladie auto-immune, la myasthénie." Vandoeuvre-les-Nancy, INPL, 1996. http://www.theses.fr/1996INPL157N.

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Ce mémoire est consacré à l'élucidation des propriétés structurales des analogues du décapeptide de la région immunogène majeure (MIR) du récepteur de l'acétylcholine (RACh) afin de détecter certaine corrélation entre leur structure et activité d'une part, et du complexe peptide MIR/anticorps d'autre part, par modélisation moléculaire. Nous avons effectué une étude comparative de la structure à l'état libre (en solution dans le DMSO et en milieu micellaire) du MIR et de plusieurs de ses [Ala]-analogues plus ou moins affines envers l'anticorps anti-RACh, et sur la structure de l'analogue [A76]M

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32

Bouzid, Makhlouf. "Polymorphisme génétique du virus d'Epstein-Barr en Afrique du Nord : étude dans le carcinome du rhinopharynx, la maladie de Hodgkin et les lymphomes malins non-Hodgkiniens." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10111.

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L'infection quasi mondiale de l'homme par le virus d'epstein-barr (ebv) contraste avec, la restriction geographique de certaines pathologies qui lui sont associees, l'incidence et la distribution en fonction de l'age variant pour une meme maladie a travers le monde. Cette situation complexe suggere l'existence de differentes souches d'ebv, specifiques de regions geographiques ou de certaines pathologies. Le carcinome du rhinopharynx (npc) est une des pathologies associees a l'ebv, qui se caracterise par une incidence intermediaire en afrique du nord en affectant deux tranches d'age de la popul

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33

Okay, Thelma Suely. "Etude de la kystogenèse de Toxoplasma Gondii chez le rat immunocompétent ou immunodéprimé et dans un modèle d'infection congénitale : caractérisation génotypique de différentes souches et clones toxoplasmiques par amplification aléatoire." Université Joseph Fourier (Grenoble), 1994. http://www.theses.fr/1994GRE10081.

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Le but de ce travail etait d'etablir un modele de toxoplasmose experimentale chez le rat qui serait bien adapte a l'etude des infections humaines. Dans un premier temps, nous avons obtenu l'attenuation d'une toxoplasmose aigue due a une souche toxoplasmique tres virulente, chez des femelles rats gestantes. Notre objectif etait de comparer l'attenuation chez l'hote adulte immunocompetent par rapport a celle observee chez des nouveau-nes immuno-immatures. La suite des travaux a concerne l'immunodepression des rats femelles gestantes prealablement infestees avec t. Gondii. Un traitement immunodep

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34

Gaudin, Philippe. "Protéolyse matricielle : étude de la gélatinase-b de 92 KDA et de son inhibiteur specifique le TIMP-1 : application à la polyarthrite rhumatoïde." Université Joseph Fourier (Grenoble), 1998. http://www.theses.fr/1998GRE10052.

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La synovite rhumatoïde représente un modèle de processus inflammatoire chronique ou le remodelage pathologique de la matrice extracellulaire est responsable de lésions anatomiques. Il dépend principalement des métalloprotéases matricielles, de certaines protéases à sérine comme les activateurs du plasminogène ou l'élastase des polynucléaires neutrophiles. Ces protéases concourent à une protéolyse focalisée qui dépend de la compartimentation des enzymes protéolytiques, de l'action d'inhibiteurs, spécifiques ou non, de la liaison enzyme-substrat, de l'éventuelle localisation membranaire des enzy

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Thumwood, Cassandra Marcinelle. "The pathogenesis of murine cerebral malaria." Phd thesis, 1987. http://hdl.handle.net/1885/142517.

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Allen, Richard James Ward. "K+ homeostasis in the malaria parasite Plasmodium falciparum." Phd thesis, 2004. http://hdl.handle.net/1885/151597.

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Pittala, Keerthana. "Malarial pathogenesis and interventions in Kelch mediated Artemisinin resistance in Plasmodium falciparum." Thesis, 2019. https://hdl.handle.net/2144/36618.

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Malaria, a parasitic disease, was commonly associated with third world countries, with the highest mortality in nations in Sub-Saharan Africa and Asia. But, travel increases the risk of spread to more temperate regions, such as Western Europe and the United States where Malaria has been successfully eradicated. In the past 40 years, with a better understanding of the mosquito vector and the parasite itself, advancements in treatment and containment have been made. Understanding the parasite as well as its pathogenesis is vital in formulating effective treatments. Following the incidences of

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Lovegrove, Fiona. "Identification of Host and Parasite Factors Mediating the Pathogenesis of Severe and Cerebral Malaria." Thesis, 2008. http://hdl.handle.net/1807/11228.

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Severe manifestations of malaria, including cerebral malaria (CM) and respiratory distress, result in approximately three million deaths annually worldwide. Currently, relatively little is known about severe disease pathogenesis. The development and outcome of severe malaria is determined by host-pathogen interactions, a complex interface of genetics and immune responses. Hypothetically, a spectrum of genetic susceptibility and resistance to severe disease exists within the host population, and malaria infection results in diverse host and parasite responses that impact disease outcome. The ai

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Henry, Roselani Ione. "Inorganic anion transport in the intraerythrocytic malaria parasite, Plasmodium falciparum." Phd thesis, 2006. http://hdl.handle.net/1885/149608.

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Chaubey, Shwetha. "Unfolded Protein Response in Malaria Parasite." Thesis, 2014. http://etd.iisc.ac.in/handle/2005/3031.

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Plasmodium falciparum is responsible for the most virulent form of human malaria. The biology of the intra-erythrocytic stage of P. falciparum is the most well studied as it is this stage that marks the clinical manifestation of malaria. To establish a successful infection, P. falciparum brings about extensive remodeling of erythrocytes, its host compartment. The infected erythrocytes harbor several parasite induced membranous structures. Most importantly, pathogenesis related structures termed knobs, which impart cytoadherence, appear on the cell surface of the infected erythrocytes. For brin

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Chaubey, Shwetha. "Unfolded Protein Response in Malaria Parasite." Thesis, 2014. http://hdl.handle.net/2005/3031.

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Plasmodium falciparum is responsible for the most virulent form of human malaria. The biology of the intra-erythrocytic stage of P. falciparum is the most well studied as it is this stage that marks the clinical manifestation of malaria. To establish a successful infection, P. falciparum brings about extensive remodeling of erythrocytes, its host compartment. The infected erythrocytes harbor several parasite induced membranous structures. Most importantly, pathogenesis related structures termed knobs, which impart cytoadherence, appear on the cell surface of the infected erythrocytes. For brin

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Martin, Rowena Elizabeth. "Mechanisms of nutrient transport in the Plasmodium falciparum-infected erythrocyte." Phd thesis, 2005. http://hdl.handle.net/1885/150847.

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Grover, Manish. "Understanding the Heat Shock Response Pathway in Plasmodium Falciparum and Identification of a Novel Exported Heat Shock Protein." Thesis, 2014. http://etd.iisc.ac.in/handle/2005/3186.

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Infections or diseases are not just stressful for the one who encounters it. The pathogens causing the same also have to deal with the hostile environment present in the host. The maintenance of physiological homeostatic balance is must for survival of all organisms. This becomes a challenging task for the protozoan parasites which often alternate between two different hosts during their life cycle and thereby encounter several environmental insults which they need to acclimatize against, in order to establish a productive infection. Since their discovery as proteins up-regulated upon heat sho

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44

Grover, Manish. "Understanding the Heat Shock Response Pathway in Plasmodium Falciparum and Identification of a Novel Exported Heat Shock Protein." Thesis, 2014. http://hdl.handle.net/2005/3186.

Full text

Abstract:

Infections or diseases are not just stressful for the one who encounters it. The pathogens causing the same also have to deal with the hostile environment present in the host. The maintenance of physiological homeostatic balance is must for survival of all organisms. This becomes a challenging task for the protozoan parasites which often alternate between two different hosts during their life cycle and thereby encounter several environmental insults which they need to acclimatize against, in order to establish a productive infection. Since their discovery as proteins up-regulated upon heat sho

APA, Harvard, Vancouver, ISO, and other styles

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