Relevant bibliographies by topics / Malat 1

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  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'Malat 1'

Author: Grafiati
Published: 4 June 2021
Last updated: 15 February 2022

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Journal articles on the topic "Malat 1"

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Wang, Jun, Yongsheng Pan, Jie Wu, Cheng Zhang, Yuan Huang, Ruizhe Zhao, Gong Cheng, et al. "The Association between Abnormal Long Noncoding RNA MALAT-1 Expression and Cancer Lymph Node Metastasis: A Meta-Analysis." BioMed Research International 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/1823482.

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Previous studies have investigated that the expression levels of MALAT-1 were higher in cancerous tissues than matched histologically normal tissues. And, to some extent, overexpression of MALAT-1 was inclined to lymph node metastasis. This meta-analysis collected all relevant articles and explored the association between MALAT-1 expression levels and lymph node metastasis. We searched PubMed, EmBase, Web of Science, Cochrane Library, and OVID to address the level of MALAT-1 expression in cancer cases and noncancerous controls (accessed February 2015). And 8 studies comprising 696 multiple cancer patients were included to assess this association. The odds ratio (OR) and its corresponding 95% confidence interval (CI) were calculated to assess the strength of the association using Stata 12.0 version software. The results revealed there was a significant difference in the incidence of lymph node metastasis between high MALAT-1 expression group and low MALAT-1 expression group (OR = 1.94, 95% CI 1.15–3.28, P=0.013 random-effects model). Subgroup analysis indicated that MALAT-1 high expression had an unfavorable impact on lymph node metastasis in Chinese patients (OR = 1.87, 95% CI 1.01–2.46). This study demonstrated that the incidence of lymph node metastasis in patients detected with high MALAT-1 expression was higher than that in patients with low MALAT-1 expression in China.
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Liu, Zhen-Feng, Qian-Ni Ye, Jun Yang, Min Yang, Dong-Hui Pan, and Meng-Jie Dong. "Preclinical evaluation of [68Ga]Ga-MALAT-1-antisense oligonucleotides for specific PET imaging of MALAT-1 expressing tumours." Nuclear Medicine Communications 42, no. 7 (March 1, 2021): 782–91. http://dx.doi.org/10.1097/mnm.0000000000001387.

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Balasis, Maria E., Jane Merelvede, Sateesh Kunigal, Xiaoyi Ren, Yan Ma, Qing Zhang, Jeff Painter, et al. "Molecular Characterization of SRSF2 Mutation Identifies a Clinically Relevant Lncrna (MALAT1) in Chronic Myelomonocytic Leukemia (CMML)." Blood 126, no. 23 (December 3, 2015): 1641. http://dx.doi.org/10.1182/blood.v126.23.1641.1641.

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Abstract SRSF2 is mutated at proline 95 (P95) in approximately 45% of patients with CMML. The consequence of SRSF2 P95H mutations on splicing has been associated with change in target RNA motif preference compared to wild type that favors CCNG over GGNG resulting in aberrant splicing abnormalities. Although this has led to several downstream mis-spliced candidates that may contribute to SRSF2 leukemic pathogenesis, the biologic consequences of SRSF2 mutation have not been fully elucidated and its effect on non-splicing pathways has yet to be explored. SRSF2 has two major functions within the nucleus: (1) bind to cis elements on pre-mRNA transcripts that functionally redefines putative exon-intron boundaries and (2) interact with other members of the spliceosome complex at nuclear suborganelles known as speckles. To explore the effects of SRSF2 P95 mutation on nuclear speckle dynamics, we transfected HeLa cells with GFP-SRSF2 wildtype (WT) and mutant (MT) constructs and performed Fluorescent Recovery After Photo-bleaching (FRAP) to determine the mutant specific kinetics of SRSF2 molecules localized to the nuclear speckle. Using this approach, we confirmed that SRSF2 WTs are characterized by complete photo-recovery with a half-life of approximately 35 (30-42) seconds as previously reported. However, when we performed FRAP of GFP-SRSF2 MTs a statistically significant difference in photo-recovery was observed compared to WT cells (Fig. 1a). The difference between baseline fluorescence and maximal recovered fluorescence in SRSF2 MT cells, or the immobile fraction, suggests that trapped bleached SRSF2 molecules are sterically inhibiting the diffusion of unbleached SRSF2 molecules. We reasoned that the observed differences in RNA binding capacity and nuclear speckle dynamics could be related. This rationale identified MALAT1 as a link connecting both increased RNA binding and nuclear speckle trafficking abnormalities because it is a Long Non-Coding (lnc) RNA that localizes to and has a critical role in SR protein recruitment and retention to the nuclear speckle. MALAT1, which is highly enriched for CCNG motifs, has also been demonstrated to bind to SRSF2 directly and has been implicated in a wide spectrum of carcinomas making it an attractive intermediary to study in our system. To determine whether SRSF2 MTs have increased MALAT1 binding capacity compared to SRSF2 WT, we performed RNA IP of myc-his-SRSF2 WT and MT transfected HeLa cells. Using this approach, we demonstrated a 60% enrichment of MALAT1 in SRSF2 WT transfected cells and a 120-150% enrichment of MALAT1 in SRSF2 MT cells compared to the empty vector control (Fig. 1b-c). We next performed the above FRAP experiment in the context of MALAT1 depletion and demonstrated that observed immobile fraction seen in SRSF2 MT cells is rescued (Fig. 1d). To determine the clinical relevance of MALAT1 in CMML we profiled a cohort of 54 CMML cases for MALAT1 expression by PCR. As shown in Figure 2a-b and d-e, MALAT1 expression is statistically elevated in CMML BMNCs and is among the highest differentially expressed transcripts in CMML monocytes (CD14+). We additionally characterized SRSF2 expression in our CMML BMNCs and CD14+ cohort and identified a linear correlation (Pearson R=0.7 p<0.05) between SRSF2 expression and MALAT1 expression (Figure 2c). Further, CMML patients with high MALAT1 expression in the BMNC compartment had inferior overall and leukemia-free survival (Fig. 2f-g). Given its relevance in solid tumors and its over-expression in CMML, we explored the consequence of MALAT1 depletion on human monocytic leukemic cells. We first performed ultra-deep RNA sequencing of the THP-1 cell line treated with two MALAT-1 depleting ASOs or matched chemistry specific controls. IPA analysis of differentially expressed transcripts identified a c-Myc gene signature that was validated by western blot analysis demonstrating reduction of c-Myc in THP-1 MALAT1-depleted cells. Colony formation assays using the THP-1 cell line demonstrated that MALAT-1 depletion resulted in decreased colony-forming capacity (CFC). MALAT-1 ASOs were also capable of depleting MALAT-1 in primary CMML BMNCs and were associated with a decreased CFC suggesting that MALAT-1 is a potential therapeutic target. Taken together, our data identifies SRSF2 P95 mutation nuclear trafficking abnormalities and identifies a novel clinically relevant lncRNA in CMML. Figure 1. Figure 1. Figure 2. Figure 2. Disclosures Komrokji: Celgene: Consultancy, Research Funding; Incite: Consultancy; Novartis: Speakers Bureau; GSK: Research Funding. List:Celgene Corporation: Honoraria, Research Funding.
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Alfaifi, Mohammed, Mirza Masroor Ali Beg, Mohammed Yahya Alshahrani, Irfan Ahmad, Ali Gaithan Alkhathami, Prakash C. Joshi, Osama M. Alshehri, Abdulrahman Manaa Alamri, and Amit Kumar Verma. "Circulating long non-coding RNAs NKILA, NEAT1, MALAT1, and MIAT expression and their association in type 2 diabetes mellitus." BMJ Open Diabetes Research & Care 9, no. 1 (January 2021): e001821. http://dx.doi.org/10.1136/bmjdrc-2020-001821.

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BackgroundType 2 diabetes mellitus (T2DM) is a multifactorial disorder that leads to alterations in gene regulation. Long non-coding RNAs (lncRNAs) have become a major research topic as they are involved in metabolic disorders.MethodsThis study included a total of 400 study subjects; 200 were subjects with T2DM and 200 were healthy subjects. Extracted RNA was used to synthesize cDNA by quantitative real time. Serum analysis was carried out to determine differences in biochemical parameters. Recorded data were used to evaluate associations with expression of lncRNAs NF-kappaB interacting lncRNA (NKILA), nuclear enriched abundant transcript 1 (NEAT1), metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), and myocardial infarction-associated transcript (MIAT) in T2DM cases.ResultsCompared with healthy controls, patients with T2DM showed an overall increase in expression of lncRNAs NKILA, NEAT, MALAT1, and MIAT by 3.94-fold, 5.28-fold, 4.46-fold, and 6.35-fold, respectively. Among patients with T2DM, higher expression of lncRNA NKILA was associated with hypertension (p=0.001), smoking (p<0.0001), and alcoholism (p<0.0001). Altered NEAT1 expression was significantly associated with weight loss (p=0.04), fatigue (p=0.01), slow wound healing (p=0.002), blurred vision (p=0.008), loss of appetite (p=0.007), smoking (p<0.0001), and alcoholism (p<0.0001). Higher expression of lncRNA MALAT1 was significantly linked with weight loss (p=0.003), blurred vision (p=0.01), smoking (p<0.0001), and alcoholism (p<0.0001). Expression of lncRNA MIAT was associated with only blurred vision (p<0.0001), smoking (p<0.0001), and alcoholism (p<0.0001). Positive correlations of lncRNA NKILA with lncRNAs NEAT1 (r=0.42, p<0.0001), MALAT (r=0.36, p<0.0001) and MIAT (r=0.42, p<0.0001) were observed among patients with T2DM. Significant positive correlations of lncRNA NEAT with lncRNAs MALAT and MIAT were observed among patients with T2DM. A positive correlation between lncRNAs MALAT and MIAT was also observed among patients with T2DM.ConclusionIncreased circulating NKILA, NEAT1, MALAT, and MIAT expression in patients with T2DM, which is linked with poor patient outcomes and significantly linked with alcoholism and smoking, may influence the degree and severity of disease among patients with T2DM. These lncRNAs may contribute to the progression of T2DM disease or other related diabetes-related complications.
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Fu, Shijian, Yanhong Wang, Hang Li, Leilei Chen, and Quanzhong Liu. "Regulatory Networks of LncRNA MALAT-1 in Cancer." Cancer Management and Research Volume 12 (October 2020): 10181–98. http://dx.doi.org/10.2147/cmar.s276022.

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Jos, B. "Ekstraksi Asam Tartrat Dan Asam Malat : Pengaruh Tri (6-Methyl) Amin Sebagai Extracting Power Dalam Berbagai Solven Terhadap Koefisien Distribusi." REAKTOR 9, no. 2 (June 19, 2017): 117. http://dx.doi.org/10.14710/reaktor.9.2.117-120.

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Limbah buangan industri minuman anggur masih mengandung asam tartrat dan asam malat. Dengan mereduksi kadar asam tartrat dan asam malat di dalam limbah akan mengurangi polusi yang ditimbulkan. Kemungkinan pengambilan kembali asam-asam ini dengan cara ekstraksi cair-cair telah berkembang. Dalam penelitian ini digunakan Tri (6-Methyl) Amin sebagai extracting power dalam berbagai solven seperti Hexanol-1; Chloroform, campuran Heptan (50%vol) + hexanol-1 (50%v); dan 2,6 DIMETHYL-4 Heptanon. Harga koefisien distribusi untuk masing-masing asam ditentukan berdasarkan konsentrasi amin dalam solven berkisar antara 0,1 sampai 0,8 mol amin per liter larutan. Koefisien distribusi asam tartrat yang diperoleh pada berbagai solven berkisar antara 2,5- 165,1; sedangakan untuk asam malat antara 1,7- 73,9. Dengan besarnya harga koefisien distribusi untuk masing-masing asam yang diperoleh Tri (6-Methyl) Amin sebagai extracting power dalam solven dapat digunakan untuk mengekstrak asam tartrat dan asam malat.Kata kunci : eksraksi cair-cair, asam tartrat, asam malat, amin
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Chen, Shaoan, Pengpeng Ma, Ying Zhao, Bin Li, Shaobo Jiang, Hui Xiong, Zheng Wang, Hanbo Wang, Xunbo Jin, and Chuan Liu. "Biological function and mechanism of MALAT-1 in renal cell carcinoma proliferation and apoptosis: role of the MALAT-1–Livin protein interaction." Journal of Physiological Sciences 67, no. 5 (September 21, 2016): 577–85. http://dx.doi.org/10.1007/s12576-016-0486-8.

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Yang, Feng, Fan Yi, Xiaorui Han, Quan Du, and Zicai Liang. "MALAT-1 interacts with hnRNP C in cell cycle regulation." FEBS Letters 587, no. 19 (August 20, 2013): 3175–81. http://dx.doi.org/10.1016/j.febslet.2013.07.048.

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Cheng, Yating, Parisa Imanirad, Indira Jutooru, Erik Hedrick, Un-Ho Jin, Aline Rodrigues Hoffman, Jeann Leal de Araujo, Benjamin Morpurgo, Andrei Golovko, and Stephen Safe. "Role of metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) in pancreatic cancer." PLOS ONE 13, no. 2 (February 1, 2018): e0192264. http://dx.doi.org/10.1371/journal.pone.0192264.

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Elamir, Azza M., Olfat G. Shaker, Mohamed HM El-Komy, Mai Mahmoud sharabi, and Nesreen M. Aboraia. "The role of LncRNA MALAT-1 and MiRNA-9 in Psoriasis." Biochemistry and Biophysics Reports 26 (July 2021): 101030. http://dx.doi.org/10.1016/j.bbrep.2021.101030.

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Dissertations / Theses on the topic "Malat 1"

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Bernard, Delphine. "Malat1 : un ARN non-codant qui contrôle la synaptogenèse." Paris 6, 2008. http://www.theses.fr/2008PA066279.

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La formation des synapses met en jeu de nombreux facteurs protéiques dont la régulation n'est pas ou peu connue. De nombreux ARN non-codants (ARNnc) sont exprimés et régulés dans le système nerveux central (SNC) mais peu de fonctions leur ont été attribué. Nous avons isolé un long ARNnc localisé dans les speckles nucléaires, appelé Malat1, enrichi dans les neurones du SNC et régulé au cours de la synaptogenèse. Nous avons montré que Malat1 est nécessaire au recrutement et/ou à la stabilisation de facteurs d'épissage particuliers, les protéines SR, aux sites de transcription actifs. Dans des cultures primaires de neurones, Malat1 régule l'expression de deux gènes synaptogéniques (neuroligine 1 et SynCAM) ainsi que la formation de synapses selon un mode autonome cellulaire. Des résultats préliminaires indiquent que Malat1 peut être induit par différents types de stress et au cours de pathologies neuronales dégénératives ou traumatiques. Ces données constituent un argument supplémentaire au consensus actuel qui place les ARNnc comme des acteurs primordiaux de la régulation de l'expression des gènes au cours du développement et du fonctionnement du SNC.
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Dahl, Josefine. "Varken hackat eller malet : En analys av ett läromedel för gymnasiekurserna Svenska 1 och Svenska som andraspråk 1." Thesis, Linnéuniversitetet, Institutionen för svenska språket (SV), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-69534.

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Syftet med denna studie är att undersöka hur ett läromedel som är anpassat för både ämnena Svenska och Svenska som andraspråk hanterar kunskapsmålen för momenten tala och skriva i kursplanerna för Svenska 1 och Svenska som andraspråk 1 i gymnasieskolan. Analysen av läromedlet har genomförts genom en jämförande närläsning av innehållet i läromedlet och innehållet i kursplanerna. Det viktigaste resultatet i studien är att ingen av elevgrupperna får samtliga kursmål tillgodosedda. Målen för skriftlig framställning tillfredställs, men resterande mål möts enbart delveis eller inte alls för respektive grupp. Det som saknas i läromedlet är för ämnet Svenska 1 argumentationsteknik, prestationsteknik samt träning i den retoriska processen. För ämnet Svenska som andraspråk 1 saknas stoff om strategier för att göra sig förstådd och förstå, men också hur språkliga koder kan användas i olika kommunikationssituationer saknas i läromedlet.
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SILVA, NETO Benedito Rodrigues da. "Malato sintase de Paracoccidioides brasiliensis é uma proteína ligada à superfície que se comporta como uma anchorless adesina." Universidade Federal de Goiás, 2009. http://repositorio.bc.ufg.br/tede/handle/tde/1295.

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Made available in DSpace on 2014-07-29T15:16:38Z (GMT). No. of bitstreams: 1 Dissert part 1 Benedito.pdf: 5001631 bytes, checksum: 7d51091e361c98586e384be80ebe9178 (MD5) Previous issue date: 2009-05-11
The pathogenic fungus Paracoccidioides brasiliensis causative of Paracoccidioidomycosis (PCM), a pulmonary mycose acquired by inhalation of fungal airborne propagules, which may disseminate to several organs and tissues leading to a severe form of the disease. Adhesion and invasion to host cells are essential steps involved in the internalization and dissemination of pathogens. Inside host, P. brasiliensis use the glyoxylate cycle for intracellular survival. Here, we provide evidence that malate synthase of P. brasiliensis (PbMLS) is localized on the cell wall, and is secreted. PbMLS was overexpressed in Escherichia coli, and polyclonal antibody against this protein was obtained. By using Confocal Laser Scanning Microscopy and Western blot analysis, PbMLS was detected in the cytoplasm and the cell wall of the yeast phase of P. brasiliensis of mother and bud yeast cells. PbMLSr and the respective polyclonal antibody produced against this protein inhibited the interaction of P. brasiliensis to in vitro cultured epithelial cells A549. These observations indicated that cell wall-associated MLS of P. brasiliensis could be mediating the binding of fungal cells, thus contributing to the adhesion of fungus to host tissues and to the dissemination of infection.
O fungo de patogênico Paracoccidioides brasiliensis agente causador da Paracoccidioidomicose (PCM), uma micose pulmonar adquirida pela inalação de propágulos aéreos do fungo que pode se disseminar a vários órgãos e tecidos levando a uma forma severa da doença. Dentro do hospedeiro, P. brasiliensis usa o ciclo do glioxalato (CG) para sobrevivência intracelular. Adesão e invasão das células do hospedeiro são passos essenciais envolvidos na internalização e disseminação do patógeno. Aqui, nós evidênciamos que malato sintase de P. brasiliensis (PbMLS) é secretada, e é localizada na parede da célula. PbMLS foi superexpressa em Escherichia coli, e o anticorpo policlonal contra esta proteína foi obtido. Usando Microscopia Laser Confocal (CLSM) e análise de Western blot, PbMLS foi encontrada no citoplasma e na parede da célula na fase leveduriforme de P. brasiliensis nas células mãe e broto. PbMLSr e o respectivo anticorpo policlonal produzido contra esta proteína inibiram a interação de P. brasiliensis com células epiteliais A549 cultivads in vitro. Estas observações indicariam que MLS associada à parede da célula de P. brasiliensis pode estar mediando a ligação do fungo às células, contribuindo assim com a adesão do fungo aos tecidos hospedeiros e para a disseminação da infecção.
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Ngah, Khalid Bin. "Deposition and diagenesis of Oligocene-Lower Miocene sandstones in the southern Malay Basin." Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46470.

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COSTA, AMANDA DANELLI. "IMPRESSIONS ON IMAGES: HISTORY MEMORY AND AUGUSTO MALTA CARIOCA PHOTOGRAPHY." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2007. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=11419@1.

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PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO
COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR
CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO
A presente dissertação busca aproximar memória e fotografia, bem como o ato de fotografar do ato de historiar. A partir daí, se volta para a proposta específica de analisar um grupo de fotografias que Augusto Malta fez das ruas da cidade do Rio de Janeiro no início do século XX. Já no século XIX foi atribuída aos fotógrafos a função de registradores de um mundo que se dissipava e de outro que se anunciava. Esses profissionais eram contratados como os responsáveis por guardarem as imagens que se transformavam rapidamente, especialmente nas cidades. Tratava-se de um desejo de construir um álbum que conservasse a memória do antes, do durante e do depois, e que servisse de registro confiável das mudanças promovidas. Esta é a função que Augusto César Malta de Campos assumiu na prefeitura da cidade-capital, comandada por Francisco Pereira Passos. É através desse caminho que se busca analisar a fotografia como artifício capaz de inventariar as transformações da cidade, uma representação fiel do mundo visível. Assim, as imagens dos Kiosques, dentre outras tantas, se tornaram instrumentos com valor de prova a serviço de um projeto modernizador da cidade-capital, numa íntima relação com a mobilização nacional em torno de uma identidade moderna que se forjava naquele tempo.
This work tries to approximate memory and photography, and at the same time the act of make photography and act of writing history. Then the work persecutes the propose of analyze a group of four photos that Augusto Malta made in the streets of Rio de Janeiro in the beginning of the 20th century. In the 19th century was given to the photographers the function of recorders of a world passing through many changes. Those professionals were hired as the responsibles to keep the images that were changing quickly, especially in the cities. There was a desire to build an album dedicated to the memory of times, and prove of the changes in the world. This was the work that Augusto Malta did for the mayor Pereira Passos. Through this way the photography is analyzed as a faithful representation of the visible world. The Kiosque s images became a prove to the project of modernization of the city, in a relation to the national mobilization around a modern identity.
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Nieuwoudt, Melanie. "LTP1 and LOX-1 in barley malt and their role in beer production and quality." Thesis, Stellenbosch : Stellenbosch University, 2014. http://hdl.handle.net/10019.1/86558.

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Thesis (PhD)--Stellenbosch University, 2014.
ENGLISH ABSTRACT: Selection of raw materials for a consistent and high quality end product has been a challenge for brewers globally. Various different factors may influence quality and although a great number of methods for malt analysis exist today for the prediction of end product quality, some still do not accurately represent malt performance in beer. This research focussed on determining parameters in malts to predict two of the major beer quality determining factors namely, foam- and flavour stability. Specific biochemical markers in barley malt such as lipid transfer protein 1 (LTP1) lipoxygenase-1 (LOX-1), anti-radical/oxidant potential (AROP), free amino nitrogen and intact protein were determined and used in beer quality prediction from malt character. These biochemical quality predictions were then correlated with the end product beer quality as assessed in sensory analysis trials on micro-brewed beers. Being such a multi-faceted factor in beer, LTP1 have already become an attractive field of study. LTP1 is primarily associated with stable beer foam, as a foam protein in its own right, and acting as a lipid scavenger. This protein is also theorised to play a role in the stability of beer flavour by possibly acting as anti-oxidant. Lastly LTP1 is known to have anti-yeast activity, which could negatively impact fermentation. In this study LTP1 and its lipid bound isoform LTP1b were successfully purified in an economical and easy five step protocol. Both isoforms showed temperature stability at temperatures >90°C and prefer more neutral and basic pH environments. Although the reported antioxidant activity was not observed, both purified LTP1 and LTP1b inhibited lipoxygenase-1 (LOX-1) activity, which is responsible for the enzymatic breakdown of linoleic acid to form 2(E)-nonenal. This is a novel finding that links LTP1 also to flavour stability. LTP1 exhibited anti-yeast activity whereas LTP1b lost most if not all the activity. However, since most of the LTP1 is converted to LTP1b and glycosylated isoforms during the brewing process fermentation will not be greatly influenced, while foam and flavour stability could still be promoted by the presence of LTP1b. Flavour deterioration of the final packaged product is partially due to the enzymatic production of 2(E)-nonenal by LOX-1 and the presence of free oxygen radical species, limited anti-radical/oxidant potential (AROP) and LTP1. The development of two 96-well micro-assays based on the ferrous oxidation-xylenol orange (FOX) assay for the determination of LOX-1 and AROP was successfully accomplished and compared well with established assays. The LOXFOX and AROP-FOX assays were specifically developed for the on-site, high throughput comparative determination of LOX-1 and AROP in malt and other brewery samples. The AROP-FOX and LOX-FOX micro-assays and a number of established assays were used to categorise malts in different predicted quality groups, various biochemical markers were measured which included LOX activity, LTP1 content, FAN values, intact protein concentration and AROP. An excellent trend (R2=0.93) was found between FAN/LOX and LTP1/LOX which also correlated with the novel observation that LOX-1 activity is inhibited by LTP1 at various concentrations. These trends could assist brewers in optimal blending for not only high quality end products but also fermentation predictions. To determine whether these biochemical markers selected for screening in barley malt are predictive of shelf life potential of the end product, sensory trials were performed. Three barley malt cultivars were selected for LOX, AROP, LTP1, protein and FAN content and used in micro-brewery trials at 0 and 3 months and evaluated using sensory analysis. Good correlation was found between the biochemical predictors and sensory trial for the best quality malt and beer. These parameters were therefore highly relevant for predicting shelf life potential, although additional research is required to elucidate the effect of LTP1 and LOX-1 on each other during the brewing process, since it seems that high LOX-1 concentrations could be leading to LTP1 decreases. With this study it is proposed that if more detailed protein or FAN characterisation is used together with the screening of LOX-1, LTP1 and AROP, an more accurate shelf life prediction, based on malt analysis, is possible and with the help of these parameters brewers can simply blend malts accordingly.
AFRIKAANSE OPSOMMING: Die keuse van roumateriaal om 'n konstante eindproduk van goeie kwaliteit te lewer, was nog altyd 'n uitdaging vir brouers wêreldwyd aangesien verskeie faktore 'n invloed het op die kwaliteit van die produk. Alhoewel daar tans verskeie metodes vir moutanalise bestaan wat die eindproduk–kwaliteit voorspel, is daar min wat werklik die eindproduk kwaliteit soos voorspel deur moutanalise verteenwoordig. Hierdie navorsing fokus op die bepaling van mout-eienskappe om twee van die belangrikste bierkwaliteitvereistes, naamlik skuim- en geurstabiliteit te voorspel. Spesifieke biochemiese eienskappe in garsmout soos lipiedtransportproteien-1 (LTP1), lipoksigenase-1 (LOX-1), antioksidant-antiradikaal potensiaal (AROP), vry aminostikstof (FAN) is geïdentifiseer en gebruik in voorspelling van bierkwaliteit vanaf moutkarakter. Hierdie biochemiese kwaliteit voorspellings is dan gekorreleer met die eindproduk soos ge-evalueer d.m.v sensoriese analise op mikro-gebroude bier. Omdat LTP1 soveel fasette in bier beïnvloed, het dit reeds 'n aanloklike studiefokus geword. LTP1 word hoofsaaklik geassosieer met stabiele skuimkwaliteit in bier en tree op as 'n lipiedmop (“lipid scavenger”). Die proteien speel teoreties ook 'n rol in die stabiliteit van bier geur deur moontlik as 'n anti-oksidant op te tree. Laastens is LTP1 bekend vir sy antigis aktiwiteit wat moontlik 'n negatiewe uitwerking op fermentasies het. Gedurende hierdie navorsing is LTP1 en sy lipiedbinding isoform LTP1b suksesvol gesuiwer met 'n ekonomies en eenvoudige 5-stap protokol. Beide isoforme het stabiliteit by temperature >90°C en meer neutrale en basiese pH omgewings getoon. Alhoewel die voorheen gerapporteerde anti-oksidant aktiwiteit vir LTP1 nie bevestig kon word nie, is daar wel gevind dat beide LTP1 en LTP1b, LOX-1, wat verantwoordelik is vir die ensimatiese afbraak van linoleensuur na 2(E)-nonenal, se aktiwiteit inhibeer. Dit is 'n unieke bevinding wat LTP1 ook koppel aan geurstabiliteit. LTP1 het antigis aktiwiteit getoon, maar LTP1b het die meeste, indien nie alle antigis-aktiwiteit verloor. Omdat die meeste van die LTP1's omgeskakel word na LTP1b's en geglikosileerde isoforme tydens die brouproses, sal fermentasie nie beduidend beinvloed word nie, maar die skuim- en geurstabiliteit sal steeds bevorder word deur die blote teenwoordigheid van die LTP1b. Geurverval van die finale verpakte produk is gedeeltelik a.g.v die ensimatiese produksie van 2(E)-nonenal deur LOX-1 en die teenwoordigheid van vry suurstofradikaal spesies, beperkte AROP en LTP1. Die ontwikkeling van twee 96-putjie mikroessaïs, gebasseer op die yster oksidasie-xilenol oranje (FOX) essai vir die bepaling van LOX-1 en AROP, was suksesvol en het goed vergelyk met reeds gevestigde essaïs. Die LOX-FOX en AROP-FOX mikroessaïs is spesifiek ontwikkel vir die residente, hoë deurvloei vergelykende bepaling van LOX-1 en AROP in mout en ander brouery-monsters. Die AROP-FOX en LOX-FOX mikroessaïs en 'n paar gevestigde essaïs is gebruik om moute te kategoriseer in die verskillende voorspelde kwaliteitsgroepe. Die biochemiese merkers wat gemeet is het die volgende ingesluit: LOX aktiwiteit, LTP1 inhoud, FAN waardes, proteïen konsentrasie en AROP. 'n Merkwaardige korrelasie (R2=0.93) is gevind tussen FAN/LOX en LTP1/LOX wat ook ooreenstem met die waarneming dat LOX-1 aktiwiteit onderdruk word deur LTP1 by verskeie konsentrasies. Hierdie korrelasies kan brouers help met optimale versnitting van moute vir, nie net die hoogste kwaliteit eindproduk nie, maar ook vir fermentasie voorspellings. Om te bepaal of hierdie geselekteerde biochemiese merkers in mout die potensieële raklewe van die eindproduk verteenwoordig, is sensoriese evaluerings uitgevoer. Drie gars-mout kultivars is geselekteer o.g.v LOX-, AROP-, LTP1-, proteïen- en FAN-inhoud en gebruik in mikro-brouery proewe en op 0 en 3 maande en is ge-evalueer deur sensoriese analise. Goeie korrelasie is gevind tussen die biochemiese voorspellers en sensoriese evaluering vir die beste kwaliteit mout en bier. Hierdie maatstawwe is daarom uiters relevant vir voorspelling van die potensiele rakleeftyd, alhoewel addisionele navorsing nodig is om die effek van LTP1 en LOX-1 op mekaar gedurende die brouproses te bepaal. Dit blyk dat 'n hoë LOX-1 konsentrasies kan lei tot 'n afname in LTP1. Met hierdie studie word dit voorstel dat, as meer gedetaileerde proteien of FAN karakterisering saam met LOX-1, LTP1, en AROP analise uitgevoer word, 'n meer akkurate raklewe voorspelling moontlik is en met behulp van hierdie parameters kan brouers moute dienooreenkomstig versnit.
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Šálková, Michaela. "Sledování obsahu 3-MCPD v ječmeni, sladu a pivu." Master's thesis, Vysoké učení technické v Brně. Fakulta chemická, 2018. http://www.nusl.cz/ntk/nusl-376823.

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The master’s thesis focuses on a process contaminant 3-MCPD (3-chloropropane-1,2-diol), which is formed during food processing. The first part of the thesis summarizes scientific knowledge about its chemical and physical properties, toxicity, occurrence in food and methods of analysis. In the second part is monitored the content of 3-MCPD in barley, in standard and special types of malts and beer. Samples were derivatized with phenylboronic acid (PBA) and 3-MCPD derivatives were analyzed by gas chromatography with a mass detector. Deuterated 3-MCPD was used as an internal standard. The limit of quantification was 1 gkg-1 for barley and malt samples and 10 gkg-1 in case of beer. The barley samples contained concentration of 3-MCPD below LOQ. In samples of malt was found concentration
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Nagamati, Junior Keize. "Análise de expressão e splicing alternativo do gene Mdh-1 de Apis mellifera L. (Hymenoptera: Apidae)." Universidade Federal de São Carlos, 2010. https://repositorio.ufscar.br/handle/ufscar/5471.

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Universidade Federal de Sao Carlos
Mdh-1 enzyme locus coding for cytoplasmic malate dehydrogenase has three common alleles Mdh-1100 (F), Mdh-180 (M) e Mdh-165 (S) and it has been extensively used as racial marker in populational studies of Apis mellifera. Additional isoforms are detected by electrophoretic analysis during ontogenetic development of A. mellifera, indicating differential expression of this locus, and a large set of evidences suggests that Mdh-1 alleles are under temperature-mediated selection. In this work, we proposed to study molecular aspects of this locus aiming to understand the nature of observed polymorphism and possible mechanisms leading to the formation of additional isoforms. Our results suggest Mdh-1100 as the ancestral allele that gave origin to alleles Mdh-180 and Mdh-165, and electrophoretic mobility differences of allelic products may be attributed to the substitution of a single aminoacid in each variant. Regarding genic expression during development, we re able to determine that both loci Mdh-1 and Mdh-2, coding for mitochondrial malate dehydrogenase, have high expression in larval and late pupal stages, and present a significant decrease in expression during transitional stages between larva and pupa. We also determined that additional isoforms are characteristic of pupae fat body and hemolymph, not being detected in other tissues, appearing at late larval stage and starting to disappear with beginning of pupal pigmentation. We were not able to identify the causes promoting the formation of the new isoforms, but our results suggest that this phenomenon is not due to alternative splicing or expression of a stage- and tissue-specific gene.
O loco enzimático Mdh-1, codificante da malato desidrogenase citoplasmática, possui três alelos comuns Mdh-1100 (F), Mdh-180 (M) e Mdh-165 (S) e tem sido extensivamente utilizado como um marcador racial nos estudos de população de Apis mellifera. Análises eletroforéticas demonstram o surgimento de isoformas adicionais durante o desenvolvimento ontogenético de A. mellifera, indicando que o loco apresenta expressão diferencial, e um amplo conjunto de evidências sugere que os alelos deste loco estão sob ação da seleção natural mediada pela temperatura. Neste trabalho, nos propusemos a estudar aspectos moleculares deste loco com o objetivo principal de entender a natureza do polimorfismo observado e os possíveis mecanismos que levam à formação das isoformas adicionais. Nossos resultados sugerem que o alelo Mdh-1100 é ancestral e originou os outros alelos Mdh-180 e Mdh-165, e que a diferença na mobilidade eletroforética dos produtos destes alelos pode ser atribuída à alteração de um único aminoácido em cada uma das variantes. Em relação à expressão gênica durante o desenvolvimento, pudemos determinar que tanto o loco Mdh-1 quanto o loco Mdh-2, codificante da malato desidrogenase mitocondrial, apresentam elevada expressão durante a fase de larva e no final da fase de pupa, e uma significativa redução durante a transição de larva a pupa. Também determinamos que as isoformas adicionais são características do corpo gorduroso e da hemolinfa, não sendo encontradas em outros tecidos, e surgem no final da fase larval e começam a desaparecer com o início da pigmentação das pupas. Não pudemos identificar as causas que promovem o aparecimento dessas novas isoformas, porém, nossos resultados sugerem que o fenômeno não deve ser devido a splicing alternativo ou expressão de um novo gene estágio- e tecido-específicos.
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Koll, Johannes. "From Vienna to Malta. Interview with former student of the Vienna University of World Trade Robert Eder." Böhlau Verlag, 2017. http://epub.wu.ac.at/6425/1/Koll_Interview_Eder.pdf.

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Abdullah, Kamsiah Binte. "The critical reading and thinking abilities of Malay secondary school pupils in Singapore." Thesis, Boston Spa, United Kindom : British Library Document Supply Centre, 1994. http://ethos.bl.uk/OrderDetails.do?did=1&uin=uk.bl.ethos.301393.

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Books on the topic "Malat 1"

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Mantot. Cursing Malay: Buku 1. Bandar Baru Bangi, Selangor: Dubook Press Sdn Bhd, 2014.

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Muhammad, Embong. Tiga sahabat: 1 Malaysia. Petaling Jaya, Selangor Darul Ehsan: Impiana Publications & Distributors Sdn. Bhd., 2011.

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Pogadaev, V. A., and B. B. Parnickel, eds. Malaysko-Indoneziyskie Issledovaniya (Malay-Indonesian Studies): Issue XI. Moscow: Drevo Zhizni, 1998.

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Zain, Shukri. Koleksi Ramadhan karim 1-8. [Bandar Seri Begawan]: Pusat Daʼwah Islamiah, Kementerian Hal Ehwal Ugama, Negara Brunei Darussalam, 2011.

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Aziz, Siti Hajar Abdul. Bahasa Melayu 1. Shah Alam, Selangor Darul Ehsan: Oxford Fajar, 2008.

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Arshad, Hang Tuah. Vokabulari Melayu-Cina: Bahagian 1 & 2. Petaling Jaya, Selangor, Malaysia]: Meoral Pub. House, 2009.

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Malta), Mdina Cathedral (Mdina, and Cathedral Museum (Mdina Malta), eds. Stampe musicali italiane alla Cattedrale di Malta: Storia e catalogo della collezione (ACM, Mus. Pr. 1-159). San Gwann, Malta: Publishers Enterprises Group, 1999.

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Malas posturas - 1. edicion. Fondo Editorial Universidad EAFIT, 2018.

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Wallace, Alfred Russel. The Malay Archipelago Volume 1. Echo Library, 2006.

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Malay Literature Volume 23 Number 1 2010. Dewan Bahasa dan Pustaka, Malaysia, 2010.

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Book chapters on the topic "Malat 1"

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Schomburg, Dietmar, and Margit Salzmann. "Malate synthase." In Enzyme Handbook 1, 403–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-86605-0_92.

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Tadmor, Uri. "Malay-Indonesian 1." In The World's Major Languages, 809–37. Third edition. | Milton Park, Abingdon, Oxon ; New York, NY : Routledge, [2018] | “First edition published by Croom Helm 1987.”: Routledge, 2018. http://dx.doi.org/10.4324/9781315644936-48.

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Schomburg, Dietmar, and Ida Schomburg. "malate dehydrogenase (quinone) 1.1.5.4." In Class 1 Oxidoreductases, 122–31. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36265-1_20.

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Morin, Izak, and Zane Goebel. "Revaluing Papuan Malay 1." In Contact Talk, 160–76. New York : Routledge, 2019.: Routledge, 2019. http://dx.doi.org/10.4324/9780429427848-10.

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Schomburg, Dietmar, and Ida Schomburg. "malate dehydrogenase [NAD(P)+] 1.1.1.299." In Class 1 Oxidoreductases, 10–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36265-1_5.

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Taylor, Ann C. M. "Malta." In International Handbook of Universities, 640. London: Palgrave Macmillan UK, 1993. http://dx.doi.org/10.1007/978-1-349-12912-6_93.

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Porciani, Ilaria, and Lutz Raphael. "Malta." In Atlas of European Historiography, 114–15. London: Palgrave Macmillan UK, 2010. http://dx.doi.org/10.1007/978-1-137-15744-7_64.

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Turner, Barry. "Malta." In The Statesman’s Yearbook, 840–45. London: Palgrave Macmillan UK, 2010. http://dx.doi.org/10.1007/978-1-349-58635-6_216.

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Said, George, and John Schembri. "Malta." In Encyclopedia of the World's Coastal Landforms, 751–59. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-1-4020-8639-7_122.

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Turner, Barry. "Malta." In The Statesman’s Yearbook, 835–39. London: Palgrave Macmillan UK, 2014. http://dx.doi.org/10.1007/978-1-349-67278-3_271.

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Conference papers on the topic "Malat 1"

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Schmidt, Lars Henning, Tilmann Spieker, Julia Humberg, Alessandro Marra, Ludger Hillejan, Wolfgang E. Berdel, Carsten Muller-Tidow, and Rainer Wiewrodt. "MALAT-1 NcRNA Enhances Cellular Migration And Wound Healing." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a6369.

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Massaeli, Hamid, Divya Viswanathan, Dhanya Pillai, and Nasrin Mesaeli. "Abstract 2343: Role of calreticulin in the regulation of MALAT-1 expression in mouse adenocarcinoma cells." In Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA. American Association for Cancer Research, 2014. http://dx.doi.org/10.1158/1538-7445.am2014-2343.

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Kulkarni, Priyanka, Pritha Dasgupta, Shahana Majid, Varahram Shahryari, Marisa Shiina, Yutaka Hashimoto, Nadeem Bhat, et al. "Abstract 2478: miR-182-5p suppresses progression of renal cancer through cell cycle arrest by targeting lncRNA MALAT-1." In Proceedings: AACR Annual Meeting 2018; April 14-18, 2018; Chicago, IL. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.am2018-2478.

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Schmidt, Lars H., Sven Hermann, Tilmann Spieker, Julia Humberg, Steffen Koschmieder, Alessandro Marra, Ludger Hillejan, et al. "The Long Non-Coding MALAT-1 RNA At 11q13 Influences Tumor Growth, Invasion And Prognosis In Non Small Cell Lung Cancer." In American Thoracic Society 2011 International Conference, May 13-18, 2011 • Denver Colorado. American Thoracic Society, 2011. http://dx.doi.org/10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a5071.

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Hsu, Jeff, Guobin He, Gourab Bhattacharjee, Tianyuan Zhou, Chris May, Brett P. Monia, Youngsoo Kim, and A. Robert MacLeod. "Abstract 2951: Potent antisense pharmacology of highly optimized antisense oligonucleotides in multiple transgenic, spontaneous and patient derived xenograft models of cancer reveals antitumor activity for the non-coding RNA MALAT-1." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-2951.

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Omar, Asmah Haji. "The Malay Language in Mainland Southeast Asia." In GLOCAL Conference on Asian Linguistic Anthropology 2019. The GLOCAL Unit, SOAS University of London, 2019. http://dx.doi.org/10.47298/cala2019.16-1.

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Today the Malay language is known to have communities of speakers outside the Malay archipelago, such as in Australia inclusive of the Christmas Islands and the Cocos (Keeling) Islands in the Indian Ocean (Asmah, 2008), the Holy Land of Mecca and Medina (Asmah et al. 2015), England, the Netherlands, France, and Germany. The Malay language is also known to have its presence on the Asian mainland, i.e. Thailand, Cambodia, and Vietnam. As Malays in these three countries belong to a minority, in fact among the smallest of the minorities, questions that arise are those that pertain to: (i) their history of settlement in the localities where they are now; (ii) the position of Malay in the context of the language policy of their country; and (iii) maintenance and shift of the ancestral and adopted languages.
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Tayeh, Brohanah, Kamila Kaping, Nadeehah Samae, and Varavejbhisis Yossiri. "The Maintenance of Language and Identities of the Thai-Melayu Ethnic Group in Jaleh Village, Yarang District, Pattani, Thailand." In GLOCAL Conference on Asian Linguistic Anthropology 2020. The GLOCAL Unit, SOAS University of London, 2020. http://dx.doi.org/10.47298/cala2020.4-1.

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At the Thai-Malaysian border, a majority of the population comprises the Thai-Melayu ethnic group, as speakers of the Pattani-Malay dialect. Here, heritage language maintenance presents a salient factor. The ethnicity resides on both sides of the border. This study aims to investigate the heritage language maintenance and identities of the Thai-Melayu ethnic group in Jaleh Village, Yarang District, Pattani, Thailand, and to examine their attitudes towards the language used in their community. The samples-set comprised 20 local respondents who were born and raised in the village. A questionnaire addressing the effects of the heritage language maintenance of the Thai-Melayu was employed as a tool of data collection. A descriptive analysis method was used for data analysis. The results of the study revealed ideological underpinnings of the ethnic group with regards to language, as well as demographic information that informs population and cultural studies. These factors include that the Pattani-Malay dialect constitutes a major language, where the Thai language in comparison has a minor usage in the community. The Pattani-Malay dialect is used in the family domain, with extended families, or with neighbors, and in ritualistic or religion domains. In contrast, Thai is used with strangers, in government and official domains, in the school domain, and in the domain of public health. Moreover, the results support that the dialect has not as yet become endangered, evidenced by that the samples prefer the Pattani-Malay dialect as the main language for daily life, and for passing on their ethnic language to younger generations, a process labeled as ‘accidental maintenance.’
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Dudás, Levente, Lajos Varga, and Rudolf Seller. "The communication subsystem of Masat-1, the first Hungarian satellite." In Photonics Applications in Astronomy, Communications, Industry, and High-Energy Physics Experiments 2009, edited by Ryszard S. Romaniuk and Krzysztof S. Kulpa. SPIE, 2009. http://dx.doi.org/10.1117/12.837484.

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Amery, Rob, and Zulfadli A. Aziz. "Enumeration and Classifiers in Pulau Simeulue/Pulau Banyak Languages, Aceh." In GLOCAL Conference on Asian Linguistic Anthropology 2019. The GLOCAL Unit, SOAS University of London, 2019. http://dx.doi.org/10.47298/cala2019.14-1.

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The counting system(s) and the use of classifiers in the languages of Pulau Simeulue and Pulau Banyak are complex. Indeed, there is more than one means of enumeration depending on the nature of the entity being counted in those languages. This study reveals strong similarities between the counting systems and classifiers used across this set of languages that differ markedly from Bahasa Indonesia and other languages of Indonesia more closely related to Malay. It provides additional evidence of the connection between the languages spoken in Simeulue and those spoken in Pulau Banyak and with Nias to the south.
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OTHMAN, NORASMAH, and NORSAIDAH ALIAS. "Business Ethics of Malay Businesspeople." In Fourth International Conference On Advances In Economics, Social Science and Human Behaviour Study - ESSHBS 2016. Institute of Research Engineers and Doctors, 2016. http://dx.doi.org/10.15224/978-1-63248-098-9-37.

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Reports on the topic "Malat 1"

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Berndt, Christian. RV SONNE Fahrtbericht / Cruise Report SO277 OMAX: Offshore Malta Aquifer Exploration, Emden (Germany) – Emden (Germany), 14.08. – 03.10.2020. GEOMAR Helmholtz Centre for Ocean Research Kiel, January 2021. http://dx.doi.org/10.3289/geomar_rep_ns_57_20.

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SO277 OMAX served two scientific projects. The objectives of the first project, SMART, were to develop multi-disciplinary methodologies to detect, quantify, and model offshore groundwater reservoirs in regions dominated by carbonate geology such as the Mediterranean Sea. To this end we acquired controlled-source electromagnetic, seismic, hydroacoustic, geochemical, seafloor imagery data off Malta. Preliminary evaluation of the geophysical data show that there are resisitivity anomalies that may represent offshore freshwater aquifers. The absence of evidence for offshore springs means that these aquifers would be confined and that it will be difficult to use them in a sustainable manner. The objective of the second project, MAPACT-ETNA, is to monitor the flank of Etna volcano on Sicily which is slowly deforming seaward. Here, we deployed six seafloor geodesy stations and six ocean bottom seismometers for long-term observation (1-3 years). In addition, we mapped the seafloor off Mt. Etna and off the island of Stromboli to constrain the geological processes that control volcanic flank stability.
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