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Dissertations / Theses on the topic 'MALDI-MSI'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

Rodrigues, Lívia Riberti 1988. "Análise de impurezas de formas farmacêuticas sólidas por MALDI Mass Spectrometry Imaging (MALDI-MSI)." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312437.

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Orientador: Rodrigo Ramos Catharino<br>Texto em português e inglês<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-25T05:33:49Z (GMT). No. of bitstreams: 1 Rodrigues_LiviaRiberti_M.pdf: 1203619 bytes, checksum: a17baf81fa013532bd6c9d451b2336f2 (MD5) Previous issue date: 2014<br>Resumo: Atualmente, as doenças cardiovasculares constituem uma das primeiras causas de mortes no Brasil e no mundo. Neste cenário, as estatinas constituem uma notável classe de medicamentos redutores de colesterol e têm sido associadas

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2

Steven, Rory Thomas. "Investigations in MALDI-MSI using a high repetition rate laser." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5392/.

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Within these studies the properties of a high repetition rate (≤ 25,000 Hz) Nd:YVO4 laser were investigated with a view to improving the throughput and quality of information obtained from MALDI MS data collected in continuous raster sampling mode. Initially, the nature of the laser beam profile was investigated and a novel fluorometric method developed for imaging these profiles. Analysis of thin film samples of α-cyano-4-hydroxycinnamic acid (CHCA) and lipid standard phophatidylcholine (PC) 34:1 were carried out. Under most conditions a lower repetition rate and slow stage raster speed were

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3

Anderson, David Michael Germaine. "Imaging the distribution of agrochemicals in plants by MALDI-MSI." Thesis, Sheffield Hallam University, 2009. http://shura.shu.ac.uk/19276/.

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Pesticides are widely used in agriculture to control weeds, pests and diseases. Successful control is dependent on the compound reaching the target site within the organism after spray or soil application. This is influenced by a range of physiological and environmental factors. One such factor is uptake into foliar tissue and roots and subsequent movement through the plant. Uptake and translocation (and metabolism) can affect the speed and persistence of action, crop selectivity and weed spectrum, thus understanding these issues is of great importance. Conventional methods for determining upt

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4

Batubara, Afnan. "Distribution of anti-cancer drugs in solid tumours studied by MALDI-MSI." Thesis, Sheffield Hallam University, 2015. http://shura.shu.ac.uk/20623/.

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Vascular disrupting agents (VDAs) have been used in treatment of many cancers. 5,6 -dimethylxanthenone-4-acetic acid (DMXAA) is a low molecular weight drug of the flavonoid group which has an anti-vascular effect in tumours causing endothelial cell apoptosis and activation of cytokines. A study employing matrix assisted laser desorption ionisation-mass spectrometry (MALDI-MS) imaging to examine LS174T colorectal adenocarcinoma xenografts following administration of DMXAA has been conducted to study the distribution of anti-cancer drugs and to explore markers of efficacy and resistance. Initial

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5

SMITH, ANDREW JAMES. "MALDI-MSI in the study of glomerulonephritis: Possible molecular indicators of CKD progression." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2017. http://hdl.handle.net/10281/153198.

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Le glomerulonefriti idiopatiche (GN), tra cui le nefropatie membranose (MN), le glomerulosclerosi segmentarie e focali (FSGS) e la nefropatia da IgA (IgAN), rappresentano le più frequenti patologie glomerulari primarie e sono spesso causa insufficienza renale terminale (ESRD). Senza una corretta diagnosi e la consegnuente scelta di un opportuno trattamento, la patologia presenta elevate probabilità di progredire verso uno stadio terminale, obbligando il paziente a sottoporsi a cicli di dialisi o al trapianto di rene. Ad oggi, la biopsia renale rimane la tecnica di elezione per la diagnosi del

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6

IVANOVA, MARIIA. "Advanced proteomics MALDI-MSI imaging in chronic glomerulonephrites: from diagnostics to precision medicine." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/263391.

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Chronical kidney disease (CKD) is a worldwide health problem with increasing incidence, where the major part accounts for chronic glomerulonephrites (GN). It is a group of diseases of various aetiology and multiform clinical course, having various prognosis which is often hardly predictable as well as existing prognostic markers are not always certain. There is an urging need of new reliable and specific prognostic and therapeutic markers research. A modern proteomic technology - Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has been employed in many GN stud

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7

Gut, Yoann. "Imagerie par spectrométrie de masse MALDI et outils chimiométriques pour la cartographie de formes pharmaceutiques solides." Thesis, Orléans, 2016. http://www.theses.fr/2016ORLE2012.

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L’agence européenne du médicament (EMA) stipule que les entreprises pharmaceutiques se doivent d’améliorer continuellement le contrôle de leur production afin de garantir la qualité des médicaments et préserver la santé des patients. Les outils analytiques classiques sont, par exemple, capables d’examiner l’intégralité d’un comprimé pharmaceutique pour contrôler la qualité et la quantité des substances actives utilisées et estimer leurs profils de libération dans l’organisme. Ils ne permettent cependant pas de cartographier la distribution des composés chimiques pourtant considérée comme un cr

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8

Djidja, M.-C., V. A. Carolan, Paul M. Loadman, and M. R. Clench. "Method development for protein profiling in biological tissues by matrix-assisted laser desorption/ionisation mass spectrometry imaging." Wiley, 2008. http://hdl.handle.net/10454/4568.

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9

DENTI, VANNA. "Development of multi-omic mass spectrometry imaging approaches to assist clinical investigations." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2022. http://hdl.handle.net/10281/365169.

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Con il termine di –omica spaziale si intende l’insieme di diverse tecniche che consentono di rilevare alterazioni significative delle biomolecole all’interno dei loro tessuti d’origine o delle strutture cellulari, permettendo quindi di integrare ed ampliare la comprensione dei cambiamenti biologici che si verificano in tessuti patologici complessi ed eterogenei, come il cancro. Tuttavia, per comprendere appieno la complessità e le dinamiche al di là delle condizioni patologiche, è necessario studiare e integrare diverse analisi molecolari, come quelle di lipidi e glicani, in modo da ottenere u

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10

GALLI, MANUEL. "AN EASY-TO-USE SOFTWARE PROGRAM FOR THE ENSEMBLE PIXEL-BY-PIXEL CLASSIFICATION OF MALDI-MSI DATASETS." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2018. http://hdl.handle.net/10281/199037.

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Introduction/Rationale: La potente tecnologia MALDI imaging permette di determinare la composizione molecolare di un campione, direttamente in situ. E’ stato comprovato in letteratura che i dati acquisiti mediante tale tecnologia possono essere utilizzati con successo a scopi clinici, in particolar modo allo scopo di fornire assistenza molecolare in casi in cui la diagnosi cito-morfologica risulti particolarmente difficoltosa. Lo scopo del lavoro di tesi è stato quello di sviluppare un software che, attraverso la sua intuitiva interfaccia grafica, potesse assistere l’utente nell’intero proces

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11

Hongming, Guo. "IMPROVING MATRIX DEPOSITION FOR SURFACE LAYER MATRIX-ASSISTED LASER DESORPTION/IONIZATION TIME-OF-FLIGHT MASS SPECTROMETRY IMAGING (SL-MALDI-TOF MSI)." University of Akron / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=akron155654549756264.

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12

Kucheriavaia, Daria. "Applications of Mass Spectrometry for Qualitative Analysis and Imaging of Microcystins in Mouse Tissues, Cyanobacterial Cells and Water." University of Toledo / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1596824964059216.

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13

Lu, Kuan. "Optimization Of Sublimation Conditions for Surface Layer Matrix-assisted Laser Desorption Ionization Time of Flight Mass Spectrometry Imaging (SL-MALDI- Tof MSI) of Polymer Surfaces." University of Akron / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=akron1524846943404769.

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14

Pratavieira, Marcel [UNESP]. "Análise metabolômica do cérebro de abelhas (Apis mellifera) submetidas a ensaio de Reflexo de Extensão de Probóscide (REP)." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/136123.

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Submitted by MARCEL PRATAVIEIRA null (marcelprata93@hotmail.com) on 2016-03-07T15:52:49Z No. of bitstreams: 1 Dissertação - Marcel Pratavieira - 2016.pdf: 8130455 bytes, checksum: a459e73ed4ef0757431f12802bc7f15b (MD5)<br>Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-03-07T19:51:13Z (GMT) No. of bitstreams: 1 pratavieira_m_me_rcla.pdf: 8130455 bytes, checksum: a459e73ed4ef0757431f12802bc7f15b (MD5)<br>Made available in DSpace on 2016-03-07T19:51:13Z (GMT). No. of bitstreams: 1 pratavieira_m_me_rcla.pdf: 8130455 bytes, checksum: a459e73ed4ef075

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15

Young, Reuben Sam Erskine. "Mapping changes to lipid metabolism within cancer using next-generation mass spectrometry technologies." Thesis, Queensland University of Technology, 2021. https://eprints.qut.edu.au/225933/1/Reuben_Young_Thesis.pdf.

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This thesis developed new methods to probe the molecular structure of lipids (fats) that are key components of cellular membranes. Applications of these technologies led to the discovery of previously undescribed lipids and allowed the mapping of their formation and fate in cancer cells and tissues. These fundamental insights into cancer metabolism suggest new targets for the detection and treatment of cancer.

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16

STELLA, MARTINA. "Identification of molecular alterations associated with the progression of clear cell Renal Cell Carcinoma by mass spectrometric approaches." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2019. http://hdl.handle.net/10281/241159.

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Il carcinoma a cellule renali rappresenta la più frequente forma di tumore al rene, e il carcinoma a cellule chiare ne è il morfotipo più ricorrente (80% dei casi). Ad oggi la nefrectomia, totale o parziale, rimane il trattamento di elezione. E’ evidente, quindi, la necessità di indagare a fondo gli aspetti molecolari associati alla progressione del tumore, con il fine ultimo di produrre conoscenze utili alla diagnosi o trattamento delle lesioni stesse. In questo lavoro abbiamo utilizzato approcci proteomici complementari per lo studio dei processi associati all’insorgenza e alla progressione

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17

Huang, Huan. "Optimizing Deposition of Matrix and Ionization Salt via Two-Step Sublimation in Sample Preparation for Surface-Layer Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry Imaging (SL-MALDI-TOF MSI)." University of Akron / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=akron1619183035472425.

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18

Åkerman, Anna, and Refel Sayfawi. "Etablering av MALDI-TOF MS och webbaserad referensdatabas för identifiering av dermatofyter och mögelsvamp." Thesis, Hälsohögskolan, Högskolan i Jönköping, HHJ, Avd. för naturvetenskap och biomedicin, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-40343.

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Syftet med studien var att etablera Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry(MALDI-TOF MS) och onlinedatabasen Mass Spectrometry identification platform(MSI) som metod för identifiering av dermatofyter och mögelsvamp. Svamparna inkuberades 3 eller 6 dagar aerobt i 30°C på Sabouraud dextros agar. Två olika extraktionsmetoder användes innan analys med MALDI-TOF MS. Spektra analyserades med Flexcontrol version 3.4 och resulterade i scorevärde. De spektra som framkom skickades även till MSI för ytterligare analys där resultat erhölls som sannolikhet i procent. A

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19

Sosnowski, Piotr. "Obrazowanie tkanek metodą spektrometrii mas MALDI-MSI." Doctoral thesis, 2016. https://depotuw.ceon.pl/handle/item/1382.

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Klasyczne przygotowanie próbek do badania, polegające na ekstrakcji substancji badanej z materiału biologicznego, zazwyczaj jest długotrwałym i skomplikowanym procesem. Obecnie dąży się do uproszczenia tych procedur, zmniejszając tym samym ingerencję w strukturę i skład próbki. Spektrometria mas z zastosowaniem metody MALDI-MSI oraz drukarka chemiczna ChIP-1000 pozwalają na bezpośrednią analizę in vitro skrawka tkanki pod względem obecności wielu różnorodnych związków naturalnych. W ramach pracy doktorskiej zoptymalizowałem metodykę nakładania matrycy na tkankę, poprzez porównanie różnych meto

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20

Luehr, Teesha Crystal. "Multiplexed matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) biomarker discovery." Thesis, 2017. https://dspace.library.uvic.ca//handle/1828/8913.

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The work presented herein is a method optimization for biomolecule detection and identification using Matrix-Assisted Laser Desorption/Ionization-Mass Spectrometry Imaging (MALDI-MSI). MALDI-MSI is a unique form of mass spectrometry that is highly multiplexed; it can simultaneously retain location information of the mass of multiple ions, allowing for correlation of morphology or pathology to reconstructed ion heat maps. There were three main objectives for the research - 1) A method optimization of sample preparation techniques for bottom-up proteomic MALDI-MSI was performed. This included th

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21

Zhang, Chao. "Proteomics characterization of HPV-independent Vulvar Cancer Tumour Progression and Metastasis by Mass Spectrometry." Thesis, 2018. http://hdl.handle.net/2440/120298.

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Vulvar cancer is the fourth most common gynecological cancer around the world, constituting 5% of all gynecological cancers and 0.6% of total cancer cases in 2016. As a relatively rare cancer type, the average vulvar cancer incidence rate is three in 100 000 women each year. But, Australian Indigenous showed significantly higher incidence rate than the global level. Previous etiological studies have identified two distinctive oncogenetic origins of vulvar cancer based on the presence of HPV infection or not. In general, over 60% of patients, especially those diagnosed at the postmenopause age

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22

Jove, M., Jade A. Spencer, M. Clench, Paul M. Loadman, and C. Twelves. "Precision pharmacology: Mass spectrometry imaging and pharmacokinetic drug resistance." 2019. http://hdl.handle.net/10454/17170.

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Yes<br>Failure of systemic cancer treatment can be, at least in part, due to the drug not being delivered to the tumour at sufficiently high concentration and/or sufficiently homogeneous distribution; this is termed as “pharmacokinetic drug resistance”. To understand whether a drug is being adequately delivered to the tumour, “precision pharmacology” techniques are needed. Mass spectrometry imaging (MSI) is a relatively new and complex technique that allows imaging of drug distribution within tissues. In this review we address the applicability of MSI to the study of cancer drug distribution f

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23

Atkinson, S. J., Paul M. Loadman, Chris W. Sutton, Laurence H. Patterson, and M. R. Clench. "Examination of the distribution of the bioreductive drug AQ4N and its active metabolite AQ4 in solid tumours by imaging matrix-assisted laser desorption/ionisation mass spectrometry." 2007. http://hdl.handle.net/10454/4572.

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no<br>AQ4N (banoxatrone) (1,4-bis-{[2-(dimethylamino-N-oxide)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione) is an example of a bioreductive prodrug in clinical development. In hypoxic cells AQ4N is reduced to the topoisomerase II inhibitor AQ4 (1,4-bis- {[2-(dimethylamino)ethyl]amino}-5,8-dihydroxyanthracene-9,10-dione). By inhibition of topoisomerase II within these hypoxic areas, AQ4N has been shown to sensitise tumours to existing chemo- and radiotherapy treatments. In this study the distribution of AQ4N and AQ4 in treated H460 human tumour xenografts has been examined by imaging matrix-a

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24

Borrego, Inês Sofia Branco. "Optimization of MALDI-TOF MSI in grapevine leaves and development of MALDI-TOF MS screening test to evidence if Resveratrol , Pterostilbenes and Synthetic Polysulfane derivates are reversible or irreversible inhibitors of Tubulin." Master's thesis, 2014. http://hdl.handle.net/10451/26770.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2015<br>MALDI-TOF MS is a rapid, accurate, specific, and reproducible method that matches all the criteria for the screening ability, it offers great possibilities and potential in terms of reactivity and analysis. The present study was divided in three different subjects: The first one consisted in the optimization of the matrix deposition by a semi- automated matrix spraying by MALDI-TOF MSI for the simultaneous location of Resveratrol, Pterostilbenes and Viniferins on Grapevine leave

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25

Juříková, Tereza. "Analýza plicních vzorků infikovaných Aspergillus fumigatus a Pseudomonas aeruginosa metodami rastrovací elektronové mikroskopie." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-380486.

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Despite the significant progress in medicine, infectious diseases are life-threatening thanks to an increasing number of multiresistant strains of microorganisms and late detection of pathological agents. An opportunistic fungus Aspergillus fumigatus cause respiratory system diseases called aspergillosis. The invasive pulmonary aspergillosis affects immunocompromised patients after inhalation of ubiquitous conidia of A. fumigatus and results in 450,000 deaths per year. The biofilm formation in the infected tissue protects A. fumigatus against antimicrobial drugs. Late therapy may not be effect

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Kaftan, Filip. "Využití DESI/DAPPI-MS a MALDI-MS pro studium biologických objektů." Doctoral thesis, 2013. http://www.nusl.cz/ntk/nusl-328154.

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(EN) Presented PhD thesis was aimed at the utilization of desorption ionization mass spectrometric techniques to study different types of biological samples. An important part of this thesis was the construction of a universal platform for ambient ionization techniques (AIT) in mass spectrometry (MS) for the experiments performed in combination with desorption electrospray ionization (DESI) and desorption atmospheric pressure photoionization (DAPPI). Initially manual platform for AIT was during the development rebuild into a motorized platform operated by software via user interface of the mas

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27

Beinsen, Alexander. "Bildgebung und chemische Analytik mit Laserdesorptions-Massenspektrometrie im Bereich Forensik und Astrophysik." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-B0A7-0.

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