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Journal articles on the topic 'MALDI-MSI'

Author: Grafiati

Published: 4 June 2021

Last updated: 10 March 2023

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1

Enomoto, Hirofumi, Masahiro Kotani, and Takayuki Ohmura. "Novel Blotting Method for Mass Spectrometry Imaging of Metabolites in Strawberry Fruit by Desorption/Ionization Using Through Hole Alumina Membrane." Foods 9, no. 4 (2020): 408. http://dx.doi.org/10.3390/foods9040408.

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Mass spectrometry imaging (MSI) using matrix-assisted laser desorption/ionization (MALDI) is a powerful technique for visualizing metabolites in the strawberry fruit. During sample preparation for MALDI-MSI, sectioning of the samples is usually required. In general, MALDI-MSI analysis of strawberry fruits that are larger than a single glass slide is difficult because thin sections cannot be prepared. In this study, we attempted to visualize metabolites in large strawberry fruits by MSI, employing a blotting method that uses desorption ionization using a through-hole alumina membrane (DIUTHAME)

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2

Bowman, Andrew P., Jeroen F. J. Bogie, Jerome J. A. Hendriks, et al. "Evaluation of lipid coverage and high spatial resolution MALDI-imaging capabilities of oversampling combined with laser post-ionisation." Analytical and Bioanalytical Chemistry 412, no. 10 (2019): 2277–89. http://dx.doi.org/10.1007/s00216-019-02290-3.

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AbstractMatrix-assisted laser desorption/ionisation-mass spectrometry imaging (MALDI-MSI) is a powerful technique for visualising the spatial locations of lipids in biological tissues. However, a major challenge in interpreting the biological significance of local lipid compositions and distributions detected using MALDI-MSI is the difficulty in associating spectra with cellular lipid metabolism within the tissue. By-and-large this is due to the typically limited spatial resolution of MALDI-MSI (30–100 μm) meaning individual spectra represent the average spectrum acquired from multiple adjacen

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3

Sommella, Eduardo, Emanuela Salviati, Vicky Caponigro, et al. "MALDI Mass Spectrometry Imaging Highlights Specific Metabolome and Lipidome Profiles in Salivary Gland Tumor Tissues." Metabolites 12, no. 6 (2022): 530. http://dx.doi.org/10.3390/metabo12060530.

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Salivary gland tumors are relatively uncommon neoplasms that represent less than 5% of head and neck tumors, and about 90% are in the parotid gland. The wide variety of histologies and tumor characteristics makes diagnosis and treatment challenging. In the present study, Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was used to discriminate the pathological regions of patient-derived biopsies of parotid neoplasms by metabolomic and lipidomic profiles. Fresh frozen parotid tissues were analyzed by MALDI time-of-flight (TOF) MSI, both in positive and negative

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4

Kanter, Frederic, Jan Lellmann, Herbert Thiele, et al. "Classification of Pancreatic Ductal Adenocarcinoma Using MALDI Mass Spectrometry Imaging Combined with Neural Networks." Cancers 15, no. 3 (2023): 686. http://dx.doi.org/10.3390/cancers15030686.

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Despite numerous diagnostic and therapeutic advances, pancreatic ductal adenocarcinoma (PDAC) has a high mortality rate, and is the fourth leading cause of cancer death in developing countries. Besides its increasing prevalence, pancreatic malignancies are characterized by poor prognosis. Omics technologies have potential relevance for PDAC assessment but are time-intensive and relatively cost-intensive and limited by tissue heterogeneity. Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) can obtain spatially distinct peptide-signatures and enables tumor classif

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5

Giampà, M., M. B. Lissel, T. Patschkowski, et al. "Maleic anhydride proton sponge as a novel MALDI matrix for the visualization of small molecules (<250 m/z) in brain tumors by routine MALDI ToF imaging mass spectrometry." Chemical Communications 52, no. 63 (2016): 9801–4. http://dx.doi.org/10.1039/c6cc02387h.

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6

Sparvero, Louis J., Andrew A. Amoscato, C. Edward Dixon, et al. "Mapping of phospholipids by MALDI imaging (MALDI-MSI): realities and expectations." Chemistry and Physics of Lipids 165, no. 5 (2012): 545–62. http://dx.doi.org/10.1016/j.chemphyslip.2012.06.001.

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7

Juříková, Tereza, Dominika Luptáková, Olga Kofroňová, et al. "Bringing SEM and MSI Closer Than Ever Before: Visualizing Aspergillus and Pseudomonas Infection in the Rat Lungs." Journal of Fungi 6, no. 4 (2020): 257. http://dx.doi.org/10.3390/jof6040257.

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A procedure for processing frozen rat lung tissue sections for scanning electron microscopy (SEM) from deeply frozen samples initially collected and stored for matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) was developed. The procedure employed slow thawing of the frozen sections while floating on the surface and melting in a fixative solution. After the float-washing step, the sections were dehydrated in a graded ethanol series and dried in a critical point dryer. The SEM generated images with well-preserved structures, allowing for monitoring of bacterial c

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8

Urbanek, Annett, Stefan Hölzer, Katrin Knop, Ulrich S. Schubert, and Ferdinand von Eggeling. "Multigrid MALDI mass spectrometry imaging (mMALDI MSI)." Analytical and Bioanalytical Chemistry 408, no. 14 (2016): 3769–81. http://dx.doi.org/10.1007/s00216-016-9465-4.

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9

Debeljak, Željko, Ann-Christin Niehoff, Ana Bandjak, et al. "MALDI TOF Mass Spectrometry Imaging of Blood Smear: Method Development and Evaluation." International Journal of Molecular Sciences 22, no. 2 (2021): 585. http://dx.doi.org/10.3390/ijms22020585.

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The aim of this study was to develop and evaluate matrix assisted LASER desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry imaging (MSI) of blood smear. Integrated light microscope and MALDI IT-TOF mass spectrometer, together with a matrix sublimation device, were used for analysis of blood smears coming from healthy male donors. Different blood plasma removal, matrix deposition, and instrumental settings were evaluated using the negative and positive ionization modes while agreement between the light microscopy images and the lateral distributions of cellular marker compound

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10

Müller, Max A., Dhaka R. Bhandari, and Bernhard Spengler. "Matrix-Free High-Resolution Atmospheric-Pressure SALDI Mass Spectrometry Imaging of Biological Samples Using Nanostructured DIUTHAME Membranes." Metabolites 11, no. 9 (2021): 624. http://dx.doi.org/10.3390/metabo11090624.

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Applications of mass spectrometry imaging (MSI), especially matrix-assisted laser desorption/ionization (MALDI) in the life sciences are becoming increasingly focused on single cell analysis. With the latest instrumental developments, pixel sizes in the micrometer range can be obtained, leading to challenges in matrix application, where imperfections or inhomogeneities in the matrix layer can lead to misinterpretation of MS images. Thereby, the application of premanufactured, homogeneous ionization-assisting devices is a promising approach. Tissue sections were investigated using a matrix-free

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11

Enomoto, Hirofumi. "Mass Spectrometry Imaging of Flavonols and Ellagic Acid Glycosides in Ripe Strawberry Fruit." Molecules 25, no. 20 (2020): 4600. http://dx.doi.org/10.3390/molecules25204600.

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Flavonols and ellagic acid glycosides are major phenolic compounds in strawberry fruit. They have antioxidant activity, show protective functions against abiotic and biotic stress, and provide health benefits. However, their spatial distribution in ripe fruit has not been understood. Therefore, matrix-assisted laser desorption/ionization (MALDI)-mass spectrometry imaging (MSI) was performed to investigate their distribution in fruit tissues. Using strawberry extract, five flavonols, namely, three kaempferols and two quercetins, and two ellagic acid glycosides, were tentatively identified by MA

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12

Debeljak, Željko, Ann-Christin Niehoff, Ana Bandjak, et al. "MALDI TOF Mass Spectrometry Imaging of Blood Smear: Method Development and Evaluation." International Journal of Molecular Sciences 22, no. 2 (2021): 585. http://dx.doi.org/10.3390/ijms22020585.

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The aim of this study was to develop and evaluate matrix assisted LASER desorption ionization (MALDI) time-of-flight (TOF) mass spectrometry imaging (MSI) of blood smear. Integrated light microscope and MALDI IT-TOF mass spectrometer, together with a matrix sublimation device, were used for analysis of blood smears coming from healthy male donors. Different blood plasma removal, matrix deposition, and instrumental settings were evaluated using the negative and positive ionization modes while agreement between the light microscopy images and the lateral distributions of cellular marker compound

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13

Bonk, Thomas, Andreas Humeny, Johannes Gebert, Christian Sutter, Magnus von Knebel Doeberitz, and Cord-Michael Becker. "Matrix-assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry-based Detection of Microsatellite Instabilities in Coding DNA Sequences: A Novel Approach to Identify DNA-Mismatch Repair-deficient Cancer Cells." Clinical Chemistry 49, no. 4 (2003): 552–61. http://dx.doi.org/10.1373/49.4.552.

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Abstract Background: Inherited defects in the DNA mismatch repair system lead to increased loss or gain of repeat units in microsatellites, commonly referred to as microsatellite instability (MSI). MSIs in coding regions of critical genes contribute to the pathogenesis of DNA-mismatch repair-deficient cancers, particularly those associated with the hereditary nonpolyposis colorectal cancer syndrome (HNPCC). MSI typing is therefore increasingly used to guide the molecular diagnosis of HNPCC. Methods: We used matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF

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14

Ellis, Shane R., Joanna Cappell, Nina Ogrinc Potočnik, et al. "More from less: high-throughput dual polarity lipid imaging of biological tissues." Analyst 141, no. 12 (2016): 3832–41. http://dx.doi.org/10.1039/c6an00169f.

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15

Mittal, Paul, Mark R. Condina, Manuela Klingler-Hoffmann, et al. "Cancer Tissue Classification Using Supervised Machine Learning Applied to MALDI Mass Spectrometry Imaging." Cancers 13, no. 21 (2021): 5388. http://dx.doi.org/10.3390/cancers13215388.

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Matrix assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) can determine the spatial distribution of analytes such as protein distributions in a tissue section according to their mass-to-charge ratio. Here, we explored the clinical potential of machine learning (ML) applied to MALDI MSI data for cancer diagnostic classification using tissue microarrays (TMAs) on 302 colorectal (CRC) and 257 endometrial cancer (EC)) patients. ML based on deep neural networks discriminated colorectal tumour from normal tissue with an overall accuracy of 98% in balanced cross-validation (98

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16

Capitoli, Piga, Galimberti, et al. "MALDI-MSI as a Complementary Diagnostic Tool in Cytopathology: A Pilot Study for the Characterization of Thyroid Nodules." Cancers 11, no. 9 (2019): 1377. http://dx.doi.org/10.3390/cancers11091377.

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The present study applies for the first time as Matrix-Assisted Laser Desorption/Ionization (MALDI) Mass Spectrometry Imaging (MSI) on real thyroid Fine Needle Aspirations (FNAs) to test its possible complementary role in routine cytology in the diagnosis of thyroid nodules. The primary aim is to evaluate the potential employment of MALDI-MSI in cytopathology, using challenging samples such as needle washes. Firstly, we designed a statistical model based on the analysis of Regions of Interest (ROIs), according to the morphological triage performed by the pathologist. Successively, the capabili

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Feucherolles, Maureen, and Gilles Frache. "MALDI Mass Spectrometry Imaging: A Potential Game-Changer in a Modern Microbiology." Cells 11, no. 23 (2022): 3900. http://dx.doi.org/10.3390/cells11233900.

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Nowadays, matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) is routinely implemented as the reference method for the swift and straightforward identification of microorganisms. However, this method is not flawless and there is a need to upgrade the current methodology in order to free the routine lab from incubation time and shift from a culture-dependent to an even faster independent culture system. Over the last two decades, mass spectrometry imaging (MSI) gained tremendous popularity in life sciences, including microbiology, due to its ability to si

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18

Greco, Francesco, Laura Quercioli, Angela Pucci, et al. "Mass Spectrometry Imaging as a Tool to Investigate Region Specific Lipid Alterations in Symptomatic Human Carotid Atherosclerotic Plaques." Metabolites 11, no. 4 (2021): 250. http://dx.doi.org/10.3390/metabo11040250.

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Atherosclerosis is characterized by fatty plaques in large and medium sized arteries. Their rupture can causes thrombi, occlusions of downstream vessels and adverse clinical events. The investigation of atherosclerotic plaques is made difficult by their highly heterogeneous nature. Here we propose a spatially resolved approach based on matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging to investigate lipids in specific regions of atherosclerotic plaques. The method was applied to a small dataset including symptomatic and asymptomatic human carotid atherosclerosis pla

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19

Michálek, Jan, Karel Štěpka, Michal Kozubek, et al. "Quantitative Assessment of Anti-Cancer Drug Efficacy From Coregistered Mass Spectrometry and Fluorescence Microscopy Images of Multicellular Tumor Spheroids." Microscopy and Microanalysis 25, no. 6 (2019): 1311–22. http://dx.doi.org/10.1017/s1431927619014983.

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AbstractSpheroids—three-dimensional aggregates of cells grown from a cancer cell line—represent a model of living tissue for chemotherapy investigation. Distribution of chemotherapeutics in spheroid sections was determined using the matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI). Proliferating or apoptotic cells were immunohistochemically labeled and visualized by laser scanning confocal fluorescence microscopy (LSCM). Drug efficacy was evaluated by comparing coregistered MALDI MSI and LSCM data of drug-treated spheroids with LSCM only data of untreated contr

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Mackay, C. L. Logan, Jens Soltwisch, Bram Heijs, et al. "Spatial distribution of isobaric androgens in target tissues using chemical derivatization and MALDI-2 on a trapped ion mobility quadrupole time-of-flight instrument." RSC Advances 11, no. 54 (2021): 33916–25. http://dx.doi.org/10.1039/d1ra06086d.

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We increase ionization efficiency and isobaric separation of derivatized androgens using MALDI-2-TIMS. First time spatial distribution of isobaric androgens is achieved in biological tissues by on-tissue chemical derivatization and MALDI-2-TIMS-MSI.

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21

Bowman, Andrew P., James Sawicki, Nari N. Talaty, Wayne R. Buck, Junhai Yang, and David S. Wagner. "Evaluation of Quantitative Platforms for Single Target Mass Spectrometry Imaging." Pharmaceuticals 15, no. 10 (2022): 1180. http://dx.doi.org/10.3390/ph15101180.

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(1) Imaging of pharmaceutical compounds in tissue is an increasingly important subsection of Mass Spectrometry Imaging (MSI). Identifying proper target engagement requires MS platforms with high sensitivity and spatial resolution. Three prominent categories of drugs are small molecule drugs, antibody-drug conjugate payloads, and protein degraders. (2) We tested six common MSI platforms for their limit of detection (LoD) on a representative compound for each category: a Matrix-Assisted Laser Desorption/Ionization (MALDI) Fourier Transform Ion Cyclotron, a MALDI-2 Time-of-Flight (ToF), a MALDI-2

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Sun, Na, Thomas Kunzke, Silviu Sbiera, et al. "Prognostic Relevance of Steroid Sulfation in Adrenocortical Carcinoma Revealed by Molecular Phenotyping Using High-Resolution Mass Spectrometry Imaging." Clinical Chemistry 65, no. 10 (2019): 1276–86. http://dx.doi.org/10.1373/clinchem.2019.306043.

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Abstract BACKGROUND Adrenocortical carcinoma (ACC) is a rare tumor with variable prognosis even within the same tumor stage. Cancer-related sex hormones and their sulfated metabolites in body fluids can be used as tumor markers. The role of steroid sulfation in ACC has not yet been studied. MALDI mass spectrometry imaging (MALDI-MSI) is a novel tool for tissue-based chemical phenotyping. METHODS We performed phenotyping of formalin-fixed, paraffin-embedded tissue samples from 72 ACC by MALDI-MSI at a metabolomics level. RESULTS Tumoral steroid hormone metabolites—estradiol sulfate [hazard rati

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23

Heireman, Laura, Sofie Patteet, and Sophia Steyaert. "Performance of the new ID-fungi plate using two types of reference libraries (Bruker and MSI) to identify fungi with the Bruker MALDI Biotyper." Medical Mycology 58, no. 7 (2020): 946–57. http://dx.doi.org/10.1093/mmy/myz138.

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Abstract During the last decade, matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) has revolutionized the diagnosis of fungal infections. Recently, a new Conidia ID-fungi plate (IDFP) medium was introduced to facilitate growth and sampling of fungi. This study aimed to evaluate the IDFP for fungal MALDI-TOF MS identification by comparison with a standard fungal growth medium using two reference libraries. A total of 75 filamentous fungal isolates (including 32 dermatophytes) were inoculated on IDFP and Sabouraud-gentamicin-chloramphenicol (SGC) agar an

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Eiersbrock, Fabian B., Julian M. Orthen, and Jens Soltwisch. "Validation of MALDI-MS imaging data of selected membrane lipids in murine brain with and without laser postionization by quantitative nano-HPLC-MS using laser microdissection." Analytical and Bioanalytical Chemistry 412, no. 25 (2020): 6875–86. http://dx.doi.org/10.1007/s00216-020-02818-y.

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Abstract MALDI mass spectrometry imaging (MALDI-MSI) is a widely used technique to map the spatial distribution of molecules in sectioned tissue. The technique is based on the systematic generation and analysis of ions from small sample volumes, each representing a single pixel of the investigated sample surface. Subsequently, mass spectrometric images for any recorded ion species can be generated by displaying the signal intensity at the coordinate of origin for each of these pixels. Although easily equalized, these recorded signal intensities, however, are not necessarily a good measure for

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Dannhorn, Andreas, Emine Kazanc, Gregory Hamm, et al. "Correlating Mass Spectrometry Imaging and Liquid Chromatography-Tandem Mass Spectrometry for Tissue-Based Pharmacokinetic Studies." Metabolites 12, no. 3 (2022): 261. http://dx.doi.org/10.3390/metabo12030261.

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Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a standard tool used for absolute quantification of drugs in pharmacokinetic (PK) studies. However, all spatial information is lost during the extraction and elucidation of a drugs biodistribution within the tissue is impossible. In the study presented here we used a sample embedding protocol optimized for mass spectrometry imaging (MSI) to prepare up to 15 rat intestine specimens at once. Desorption electrospray ionization (DESI) and matrix assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) were employed to

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Galli, Manuel, Italo Zoppis, Andrew Smith, Fulvio Magni, and Giancarlo Mauri. "Machine learning approaches in MALDI-MSI: clinical applications." Expert Review of Proteomics 13, no. 7 (2016): 685–96. http://dx.doi.org/10.1080/14789450.2016.1200470.

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Svirkova, Anastasiya, Anna Turyanskaya, Lukas Perneczky, Christina Streli та Martina Marchetti-Deschmann. "Multimodal imaging of undecalcified tissue sections by MALDI MS and μXRF". Analyst 143, № 11 (2018): 2587–95. http://dx.doi.org/10.1039/c8an00313k.

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Rodrigues, Lívia Riberti, Diogo Noin de Oliveira, Mônica Siqueira Ferreira, and Rodrigo Ramos Catharino. "In situ assessment of atorvastatin impurity using MALDI mass spectrometry imaging (MALDI-MSI)." Analytica Chimica Acta 818 (March 2014): 32–38. http://dx.doi.org/10.1016/j.aca.2014.01.050.

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Islam, Ariful, Takumi Sakamoto, Qing Zhai, et al. "Application of AP-MALDI Imaging Mass Microscope for the Rapid Mapping of Imipramine, Chloroquine, and Their Metabolites in the Kidney and Brain of Wild-Type Mice." Pharmaceuticals 15, no. 11 (2022): 1314. http://dx.doi.org/10.3390/ph15111314.

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Mass spectrometry imaging (MSI) is well-known for the non-labeling visualization of analytes, including drugs and their metabolites in biological samples. In this study, we applied three different tools of MSI, desorption electrospray ionization (DESI)-MSI, matrix-assisted laser desorption ionization (MALDI)-MSI, and a newly developed atmospheric pressure (AP)-MALDI-MSI known as iMScopeTM QT for rapid mapping of imipramine, chloroquine, and their metabolites in C57BL/6 male wild-type mice. Among three MSI tools, better detection capability for targeted drugs at higher speed (up to 32 pixels/s)

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Sgobba, Elvira, Yohann Daguerre, and Marco Giampà. "Unravel the Local Complexity of Biological Environments by MALDI Mass Spectrometry Imaging." International Journal of Molecular Sciences 22, no. 22 (2021): 12393. http://dx.doi.org/10.3390/ijms222212393.

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Classic metabolomic methods have proven to be very useful to study functional biology and variation in the chemical composition of different tissues. However, they do not provide any information in terms of spatial localization within fine structures. Matrix-assisted laser desorption ionization mass spectrometry imaging (MALDI MSI) does and reaches at best a spatial resolution of 0.25 μm depending on the laser setup, making it a very powerful tool to analyze the local complexity of biological samples at the cellular level. Here, we intend to give an overview of the diversity of the molecules a

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Mezger, Stephanie T. P., Alma M. A. Mingels, Matthieu Soulié, et al. "Protein Alterations in Cardiac Ischemia/Reperfusion Revealed by Spatial-Omics." International Journal of Molecular Sciences 23, no. 22 (2022): 13847. http://dx.doi.org/10.3390/ijms232213847.

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Myocardial infarction is the most common cause of death worldwide. An understanding of the alterations in protein pathways is needed in order to develop strategies that minimize myocardial damage. To identify the protein signature of cardiac ischemia/reperfusion (I/R) injury in rats, we combined, for the first time, protein matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) and label-free proteomics on the same tissue section placed on a conductive slide. Wistar rats were subjected to I/R surgery and sacrificed after 24 h. Protein MALDI-MSI data revealed ischemia

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Denti, Vanna, Allia Mahajneh, Giulia Capitoli, et al. "Lipidomic Typing of Colorectal Cancer Tissue Containing Tumour-Infiltrating Lymphocytes by MALDI Mass Spectrometry Imaging." Metabolites 11, no. 9 (2021): 599. http://dx.doi.org/10.3390/metabo11090599.

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Predicting the prognosis of colorectal cancer (CRC) patients remains challenging and a characterisation of the tumour immune environment represents one of the most crucial avenues when attempting to do so. For this reason, molecular approaches which are capable of classifying the immune environments associated with tumour infiltrating lymphocytes (TILs) are being readily investigated. In this proof of concept study, we aim to explore the feasibility of using spatial lipidomics by MALDI-MSI to distinguish CRC tissue based upon their TIL content. Formalin-fixed paraffin-embedded tissue from huma

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Ucal, Yasemin, and Aysel Ozpinar. "Improved spectra for MALDI MSI of peptides using ammonium phosphate monobasic in MALDI matrix." Journal of Mass Spectrometry 53, no. 8 (2018): 635–48. http://dx.doi.org/10.1002/jms.4198.

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Jaegger, C. F., F. Negrão, D. M. Assis, et al. "MALDI MS imaging investigation of the host response to visceral leishmaniasis." Molecular BioSystems 13, no. 10 (2017): 1946–53. http://dx.doi.org/10.1039/c7mb00306d.

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Enomoto, Hirofumi, Tomohiro Furukawa, Shiro Takeda, Hajime Hatta, and Nobuhiro Zaima. "Unique Distribution of Diacyl-, Alkylacyl-, and Alkenylacyl-Phosphatidylcholine Species Visualized in Pork Chop Tissues by Matrix-Assisted Laser Desorption/Ionization–Mass Spectrometry Imaging." Foods 9, no. 2 (2020): 205. http://dx.doi.org/10.3390/foods9020205.

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Phosphatidylcholine (PC) is the major phospholipid in meat and influences meat qualities, such as healthiness. PC is classified into three groups based on the bond at the sn-1 position: Diacyl, alkylacyl, and alkenylacyl. To investigate their composition and distribution in pork tissues, including longissimus thoracis et lumborum (loin) spinalis muscles, intermuscular fat, and transparent tissues, we performed matrix-assisted laser desorption/ionization–mass spectrometry imaging (MALDI–MSI). Eleven diacyl-, seven alkylacyl-, and six alkenylacyl-PCs were identified using liquid chromatography (

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Noun, Manale, Rayane Akoumeh, and Imane Abbas. "Cell and Tissue Imaging by TOF-SIMS and MALDI-TOF: An Overview for Biological and Pharmaceutical Analysis." Microscopy and Microanalysis 28, no. 1 (2021): 1–26. http://dx.doi.org/10.1017/s1431927621013593.

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AbstractThe potential of mass spectrometry imaging (MSI) has been demonstrated in cell and tissue research since 1970. MSI can reveal the spatial distribution of a wide range of atomic and molecular ions detected from biological sample surfaces, it is a powerful and valuable technique used to monitor and detect diverse chemical and biological compounds, such as drugs, lipids, proteins, and DNA. MSI techniques, notably matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) and time of flight secondary ion mass spectrometry (TOF-SIMS), witnessed a dramatic upsurge in studying and

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Wang, Xin, Yuning Chen, Yue Liu, et al. "Visualizing the Distribution of Lipids in Peanut Seeds by MALDI Mass Spectrometric Imaging." Foods 11, no. 23 (2022): 3888. http://dx.doi.org/10.3390/foods11233888.

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Peanut (also called groundnut, Arachis hypogaea L.) seeds are used for producing edible oils and functional foods, and offer a rich source of lipids, proteins and carbohydrates. However, the location of these metabolites has not yet been firmly established. In the present study, the matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI-MSI) technique was applied to investigate spatial distribution of lipids and other key components in seeds of three peanut cultivars (ZH9, KQBH, HP). A total of 103 metabolites, including 34 lipid compounds, were putatively identified by

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Motomura, Naoki, Yuto Yamazaki, Gao Xin, et al. "Visualization of Ca Channel Blocker on Human Adrenal Tissue by Mass Spectrometry Imaging ~Its Predominant Distribution at Aldosterone-Producing Cells ~." Journal of the Endocrine Society 5, Supplement_1 (2021): A304. http://dx.doi.org/10.1210/jendso/bvab048.619.

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Abstract Primary aldosteronism (PA) is the main cause of secondary hypertension, accounting for approximately 5–10% of all hypertension. Amlodipine, a third-generation calcium channel blocker, is one of the most frequently administered pharmaceuticals medications of hypertension, binds specifically to Cav1.2, a calcium channel primarily localized in the cardiovascular system, and exerts antihypertensive effects through inhibiting calcium influx into the vascular smooth muscle cells. In addition, calcium influx also plays important roles in aldosterone production and amlodipine was also reporte

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Wang, Tao, Hin Kiu Lee, Grace Gar Lee Yue, Arthur Chi Kong Chung, Clara Bik San Lau, and Zongwei Cai. "A novel binary matrix consisting of graphene oxide and caffeic acid for the analysis of scutellarin and its metabolites in mouse kidney by MALDI imaging." Analyst 146, no. 1 (2021): 289–95. http://dx.doi.org/10.1039/d0an01539c.

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Erlmeier, Franziska, Na Sun, Jian Shen, et al. "MALDI Mass Spectrometry Imaging—Prognostic Pathways and Metabolites for Renal Cell Carcinomas." Cancers 14, no. 7 (2022): 1763. http://dx.doi.org/10.3390/cancers14071763.

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High mass resolution matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is a suitable method for biomarker detection for several tumor entities. Renal cell carcinoma (RCC) is the seventh most common cancer type and accounts for more than 80% of all renal tumors. Prognostic biomarkers for RCC are still missing. Therefore, we analyzed a large, multicenter cohort including the three most common RCC subtypes (clear cell RCC (ccRCC), papillary RCC (pRCC) and chromophobe RCC (chRCC)) by MALDI for prognostic biomarker detection. MALDI-Fourier-transform ion cyclotron r

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Morawietz, Carolin M., Alejandra M. Peter Ventura, Christoph G. Grevelding, Simone Haeberlein, and Bernhard Spengler. "Spatial visualization of drug uptake and distribution in Fasciola hepatica using high-resolution AP-SMALDI mass spectrometry imaging." Parasitology Research 121, no. 4 (2022): 1145–53. http://dx.doi.org/10.1007/s00436-021-07388-1.

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AbstractUnderstanding drug penetration, distribution, and metabolization is fundamental for understanding drug efficacy. This also accounts for parasites during antiparasitic treatment. Recently, we established matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) in blood flukes and liver flukes. This label-free technique is capable of visualizing the molecular distribution of endogenous and exogenous molecules, such as drug compounds. Here, we conducted atmospheric-pressure scanning microprobe MALDI MSI (AP-SMALDI MSI) of tissue sections of adult Fasciola hepati

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Pietkiewicz, Dagmara, Agnieszka Horała, Szymon Plewa, et al. "MALDI-MSI—A Step Forward in Overcoming the Diagnostic Challenges in Ovarian Tumors." International Journal of Environmental Research and Public Health 17, no. 20 (2020): 7564. http://dx.doi.org/10.3390/ijerph17207564.

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This study presents the use of matrix-assisted laser desorption and ionization mass spectrometry imaging (MALDI-MSI) directly on the tissue of two ovarian tumors that often present a diagnostic challenge, a low-grade serous borderline ovarian tumor and ovarian fibrothecoma. Different spatial distribution of m/z values within the tissue samples was observed, and regiospecific peaks were identified. Among the 106 peaks in the borderline ovarian tumor five, regiospecific peaks (m/z: 2861.35; 2775.79; 3368.34; 3438.43; 4936.37) were selected using FlexImaging software. Subsequently, the distributi

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De Sio, Gabriele, Andrew James Smith, Manuel Galli, et al. "A MALDI-Mass Spectrometry Imaging method applicable to different formalin-fixed paraffin-embedded human tissues." Molecular BioSystems 11, no. 6 (2015): 1507–14. http://dx.doi.org/10.1039/c4mb00716f.

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The paper shows a new method for the application of Matrix Assisted Laser Desorption/Ionisation (MALDI) Mass Spectrometry Imaging (MSI) technology on formalin-fixed paraffin-embedded (FFPE) tissue samples.

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Hu, Wenya, Honggang Nie, Yinghao Wang, et al. "Tracing the migration and transformation of metabolites in xylem during wood growth by mass spectrometry imaging." Analyst 147, no. 8 (2022): 1551–58. http://dx.doi.org/10.1039/d1an02251b.

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Crecelius, A. C., U. S. Schubert, and F. von Eggeling. "MALDI mass spectrometric imaging meets “omics”: recent advances in the fruitful marriage." Analyst 140, no. 17 (2015): 5806–20. http://dx.doi.org/10.1039/c5an00990a.

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Matrix-assisted laser desorption/ionization mass spectrometric imaging (MALDI MSI) is a method that allows the investigation of the molecular content of surfaces, in particular, tissues, within its morphological context.

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Capitoli, Giulia, Isabella Piga, Vincenzo L’Imperio, et al. "Cytomolecular Classification of Thyroid Nodules Using Fine-Needle Washes Aspiration Biopsies." International Journal of Molecular Sciences 23, no. 8 (2022): 4156. http://dx.doi.org/10.3390/ijms23084156.

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Fine-needle aspiration biopsies (FNA) represent the gold standard to exclude the malignant nature of thyroid nodules. After cytomorphology, 20–30% of cases are deemed “indeterminate for malignancy” and undergo surgery. However, after thyroidectomy, 70–80% of these nodules are benign. The identification of tools for improving FNA’s diagnostic performances is explored by matrix-assisted laser-desorption ionization mass spectrometry imaging (MALDI-MSI). A clinical study was conducted in order to build a classification model for the characterization of thyroid nodules on a large cohort of 240 samp

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Castellanos-Garcia, Laura J., Kristen N. Sikora, Jeerapat Doungchawee, and Richard W. Vachet. "LA-ICP-MS and MALDI-MS image registration for correlating nanomaterial biodistributions and their biochemical effects." Analyst 146, no. 24 (2021): 7720–29. http://dx.doi.org/10.1039/d1an01783g.

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Laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS) imaging and matrix assisted laser desorption ionization mass spectrometry imaging (MALDI-MSI) can measure distributions of elements and biomolecules in tissue sections.

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Strnad, Štěpán, Veronika Pražienková, Martina Holubová, et al. "Mass spectrometry imaging of free-floating brain sections detects pathological lipid distribution in a mouse model of Alzheimer's-like pathology." Analyst 145, no. 13 (2020): 4595–605. http://dx.doi.org/10.1039/d0an00592d.

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The applicability of paraformaldehyde-fixed free-floating sections for the MALDI MSI of lipids was studied and the developed procedure was used for studying lipid changes in a mouse model of Alzheimer's pathology.

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He, Quan, Cuirong Sun, Jian Liu, and Yuanjiang Pan. "MALDI-MSI analysis of cancer drugs: Significance, advances, and applications." TrAC Trends in Analytical Chemistry 136 (March 2021): 116183. http://dx.doi.org/10.1016/j.trac.2021.116183.

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Worthmann, Anna, and Alexander Bartelt. "MALDI MSI for a fresh view on atherosclerotic plaque lipids." Pflügers Archiv - European Journal of Physiology 474, no. 2 (2021): 185–86. http://dx.doi.org/10.1007/s00424-021-02654-8.

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