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Dissertations / Theses on the topic 'MALDI'

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Published: 4 June 2021
Last updated: 25 July 2025

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1

Rodrigues, Lívia Riberti 1988. "Análise de impurezas de formas farmacêuticas sólidas por MALDI Mass Spectrometry Imaging (MALDI-MSI)." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312437.

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Orientador: Rodrigo Ramos Catharino<br>Texto em português e inglês<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-25T05:33:49Z (GMT). No. of bitstreams: 1 Rodrigues_LiviaRiberti_M.pdf: 1203619 bytes, checksum: a17baf81fa013532bd6c9d451b2336f2 (MD5) Previous issue date: 2014<br>Resumo: Atualmente, as doenças cardiovasculares constituem uma das primeiras causas de mortes no Brasil e no mundo. Neste cenário, as estatinas constituem uma notável classe de medicamentos redutores de colesterol e têm sido associadas
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2

Lai-Rowcroft, Lindsay Ling Gi. "Novel surfaces for MALDI-MS." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/novel-surfaces-for-maldims(331dd97a-881e-4ed0-908f-d5947f3ebeba).html.

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Matrix assisted laser desorption/ionisation mass spectrometry (MALDI-MS) for small molecule analysis has been plagued with inherent problems associated with matrix interference. The matrix plays an important role in MALDI-MS where it has the ability to absorb UV energy from the laser employed and transfer it to the analyte, acts as a proton donor and protecting the analytes from being obliterated. For decades, research has been performed to eradicate matrix interference by matrix avoidance, finding alternative matrices, suppression through sample preparation methods and via chemical modificati
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3

Tandina, Fatalmoudou. "Mise au point et application de technologies innovantes pour l'étude des moustiques, de leur préférence trophique et de leur microbiote." Thesis, Aix-Marseille, 2018. http://www.theses.fr/2018AIXM0277/document.

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Les moustiques sont les principaux vecteurs incriminés dans la transmission d’agents pathogènes à l’homme. L’identification précise des espèces de moustiques est importante pour distinguer les espèces vectrices des non vectrices. La détermination de l’origine du repas sanguin des moustiques vecteurs est indispensable dans la compréhension du comportement des espèces vectrices. Nous avons mise à jour la littérature actuelle sur la faune Culicidienne du Mali. Ainsi, nous avons listé 106 espèces de moustiques actuellement enregistrée au Mali dont 28 Anophelinae et 78 Culicinae. Nous avons ensuite
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4

Krüger, Ralf. "Untersuchungen zum Einbau von Analytionen in MALDI-Matrizes sowie zur Ionisation und Adduktbildung in der MALDI-Massenspektrometrie." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=969681682.

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5

Kirmess, Kristopher Michael. "Investigation of Primary Ion Formation Mechanisms in UV-MALDI-MS Using Excited State Dynamics of Common MALDI Matrices." OpenSIUC, 2015. https://opensiuc.lib.siu.edu/dissertations/1110.

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The motivation of this dissertation is to provide insight towards primary ionization mechanisms within MALDI mass spectrometry. Albeit MALDI-MS is an extensively used analytical technique, the mechanism in which primary ions are created is still under scrutiny. Two current models of primary ionization exist which claim to elucidate the ion formation mechanisms within MALDI. In this work, excited state dynamics of MALDI matrices are shown to play an important role in the ionization mechanism. Upon inspection of the thermodynamic properties of commonly used MALDI matrices, no correlation was
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6

Collazo, Verena. "Reverse Sanger-Sequenzierung mittels MALDI-TOF-Massenspektrometrie." [S.l.] : [s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=964226871.

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7

Enebro, Jonas. "Characterization of carboxymethyl cellulose by MALDI-TOFMS /." Stockholm : [Fiber och polymerteknologi, Kungliga Tekniska högskolan], 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4376.

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8

Leander, Ellinor. "Artidentifiering av mögelsvamp med MALDI-TOF MS." Thesis, Linnéuniversitetet, Institutionen för kemi och biomedicin (KOB), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-80166.

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Snabb och korrekt artidentifiering är avgörande för effektiv behandling av svampinfektioner, särskilt bland immunsupprimerade patienter. Matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) används rutinmässigt på kliniska laboratorier för identifiering av karaktäristiska proteinmönster hos bakterier och jästsvampar genom tolkning av proteinspektra i en masspektradatabas för korrekt artidentifiering. Mögelsvamparnas hårda cellvägg och heterogena växtsätt med varierande proteinuttryck beroende på mognadsstadie, försvårar identifiering med MALDI-TOF MS. Met
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9

Stauber, Jonathan. "Imagerie MALDI : nouveaux développements et applications cliniques." Lille 1, 2007. https://pepite-depot.univ-lille.fr/LIBRE/Th_Num/2007/50376-2007-379.pdf.

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Les avancées de la biologie moléculaire se sont également réalisées avec l’évolution des techniques d’imagerie dans les domaines de la génomique. La transcriptomique et plus récemment de la protéomique grâce ù l'essor d'un outil essentiel, la spectrométrie de masse. Cette technique a trouvé sa place pour générer des profils protéiques caractéristiques de l'état physiologique de la cellule, de fluides complexes tels que le sang ou les urines. Elle apparaît aujourd'hui comme un outil indissociable de la recherche en biologie et en médecine. Les nouveaux développements tendent à conduire la spect
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10

Jacksén, Johan. "Improved techniques for CE-MALDI-MS off-line coupling and MALDI-MS analysis of primarily hydrophobic proteins and peptides." Licentiate thesis, KTH, Chemistry, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4599.

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<p>Due to the hydrophobic nature of integral membrane proteins (IMP) they give rise to several difficulties concerning handling and analysis, which is not the case for the most water soluble proteins. New analysis methods are needed, where the insolubility problems of the hydrophobic proteins due to aggregation and adhesion are tackled. Those problems also affect digestion performance and equipment compatibility for the analysis.</p><p>Protocols for analysis and separation specified for IMP are presented in <b>Paper I</b> and<b> III</b>.</p><p>The instrumentation used in this work was capillar
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11

Neubert, Hendrik. "An investigation into the enhancement of MALDI-MS by modification of surface chemistries (MALDI, matix-assisted laser desorption/ionisation)." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396347.

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12

PENG, LIJUAN. "MATRIX-ASSISTED LASER DESORPTION/IONIZATION (MALDI) TARGET MODIFICATION FOR ENHANCED PROTEOMICS ANALYSIS AND PLASMA POLYMER CHARACTERIZATION BY MALDI MASS SPECTROMETRY." OpenSIUC, 2010. https://opensiuc.lib.siu.edu/dissertations/207.

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The work described in this dissertation is divided into three sections. In the first section three surface modifications are used to produce MALDI targets having reduced surface-protein binding affinity with a goal of increasing peptide/protein MALDI ion signals and lowering the limits of detection (LODs) for proteins and peptides. The second section discusses a bioselective MALDI target, produced via radio frequency (rf) plasma deposited ethylenediamine (EDA), for on-target separation of complex protein mixtures. The third section develops a new approach for characterization of rf plasma-depo
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13

Dallacker-Losensky, Kevin. "Identifizierung von obligaten Anaerobiern der Bacteroides fragilis Gruppe einschließlich Metronidazol-resistenter und Enterotoxin-positiver Stämme mittels MALDI-TOF MS." Doctoral thesis, Universitätsbibliothek Leipzig, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-206555.

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Die klassische Identifizierung von obligat anaeroben Bakterien ist mit einem hohen Labor- und Zeitaufwand verbunden. Um festzustellen, ob die Identifizierung mittels Matrix-unterstützter Laser-Desorption/Ionisation und Massenspektrometrie mit Flugzeitanalysator (Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry; MALDI-TOF MS) ein Verfahren ist, um obligate Anaerobier eindeutig zu identifizieren, wurde mit der vorliegenden Arbeit die Identifizierung von unterschiedlichen Spezies der B. fragilis Gruppe mittels MALDI-TOF MS untersucht. Hierfür wurden 105 obligate Anaer
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14

Zechmann, Carsten. "Spektroskopische Untersuchung der Lumineszenzerscheinungen beim UV-MALDI-Desorptionsprozess." [S.l. : s.n.], 2001. http://e-diss.uni-kiel.de/diss/d440.pdf.

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15

Bouschen, Werner. "Ortsaufgelöste MALDI-Massenspektrometrie an biologischen und synthetischen Oberflächen." [S.l. : s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971766886.

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16

Kempka, Martin. "Improved mass accuracy in MALDI-TOF-MS analysis." Licentiate thesis, Stockholm : Division of Analytical Chemistry, Royal Institute of Technology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-313.

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17

Kriegsmann, Mark. "MALDI MS Imaging zur Untersuchung von synovialem Gewebe." Doctoral thesis, Universitätsbibliothek Leipzig, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-118897.

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18

Enthaler, Bernd [Verfasser]. "MALDI imaging in ex-vivo skin / Bernd Enthaler." München : Verlag Dr. Hut, 2014. http://d-nb.info/1049363086/34.

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19

Halgunset, Anders. "Typing av Legionella pneumophila med MALDI-TOF MS." Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for bioteknologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-24697.

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Legionella pneumophila er fakultativ intracellul&#230;re bakterier som lever naturlig i akvatiske habitater. De kan replikere i makrofager og protozoer, bli overf&#248;rt til mennesker gjennom areosoler og f&#248;re til smitte. Ved eventuelle utbrudd er det viktig &#229; kunne identifisere kilden, noe som i dag bli gjort ved &#229; typebestemme L. pneumophila med sekvensbasert typing (SBT). Samtidig har matrix-assisted laser desorption/ionization ? time-of-flight (MALDI?TOF) mass spectrometry (MS) vist seg &#229; kunne brukes til rask og effektiv identifisering av en rekke mikroorganismer p&#2
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20

Trim, Paul James. "MALDI-MS imaging for direct drug distribution analysis." Thesis, Sheffield Hallam University, 2009. http://shura.shu.ac.uk/20455/.

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MALDI Imaging has gained huge interest in the past few years with an ever increasing population of specialists choosing to investigate samples using MALDI imaging, including growing interest and financial backing from pharma and contract research organisations. Presented within this thesis is the development and application of MALDI imaging techniques for a variety of analytical problems. The use of various software packages have been employed in the interpretation of the data acquired from MALDI experiments including, the use of statistical analysis for the identification of ion of interest f
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21

Sun, Zhen. "Studies of Atmospheric Pressure Visible-Wavelength MALDI-MS." University of Toledo / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1333747638.

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22

Eastwood, Stephanie. "Development of Amine Containing Polymer Modified MALDI Targets for Complex Peptide and Protein Mixture Fractionation Prior to MALDI Mass Spectrometry Analysis." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/dissertations/948.

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AN ABSTRACT OF THE DISSERATION OF STEPHANIE EASTWOOD, for the Doctor of Philosophy degree in CHEMISTRY, presented on the DATE OF DEFENSE, at Southern Illinois University Carbondale. TITLE: DEVELOPMENT OF AMINE CONTAINING POLYMERIC MODIFIED MALDI TARGET SUBSTRATES FOR COMPLEX MIXTURE FRACTIONATION OF PEPTIDE AND PROTEIN MIXTURES PRIOR TO MALDI MASS SPECTROMETRY ANALYSIS MAJOR PROFESSOR: Dr. Gary Kinsel The focus of this dissertation is the synthesis, development and application of the amine containing modified targets for the fractionation of complex mixtures of peptides and digested proteins
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23

Seyer, Alexandre. "Imagerie par spectrométrie de masse : développements méthodologiques et applications biologiques." Thesis, Evry-Val d'Essonne, 2010. http://www.theses.fr/2010EVRY0028/document.

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Mon travail de thèse a consisté à poursuivre le développement de l’Imagerie par Spectrométrie de Masse (IMS), à la fois sur le plan méthodologique mais aussi à travers des applications biologiques.Dans une première partie est exposé le développement d’une méthode de préparation des échantillons de très petite taille pour l’imagerie chimique, et plus particulièrement pour l’imagerie TOF-SIMS. Cette méthode a pu être validée en étudiant des molécules de la famille des flavonoïdes dans différents types de graines d’Arabidopsis thaliana ne mesurant que 400 nm de diamètre. La seconde partie, dédiée
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24

Sandonato, Beatriz Brabetz [UNESP]. "Peptídeos cíclicos hepatotóxicos: MALDI-TOF como uma ferramenta analítica." Universidade Estadual Paulista (UNESP), 2014. http://hdl.handle.net/11449/123921.

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Made available in DSpace on 2015-06-17T19:34:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-03-12. Added 1 bitstream(s) on 2015-06-18T12:49:05Z : No. of bitstreams: 1 000832493.pdf: 1769807 bytes, checksum: e6c5bb7d9bcec2a173427a67060a8dce (MD5)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>As cianobactérias são bactérias fotossintetizantes que podem ser encontradas nos mais variados ambientes. Algumas espécies de cianobactérias produzem toxinas denominadas cianotoxinas. As cianotoxinas denominadas microcistinas (MCs) são heptapeptídeos cíclicos hepatotóxicos
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uk, siricordcc@yahoo co, and Cornelia Charito Siricord. "Detection of Phytophthora species by MALDI-TOF mass spectrometry." Murdoch University, 2005. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20070717.125452.

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Phytophthora diseases have caused worldwide economic, social and environmental impacts for decades. Once their presence is confirmed, they are difficult to eradicate. To reduce and manage the damage inflicted by the pathogen, fast and reliable disease management protocols are required. Tests that enable the rapid and reliable identification of the pathogen assist greatly in disease management. Phytophthora species are traditionally not only detected by baiting but also by plating of symptomatic tissue on selective media. Species can be identified by the characteristics of the mycelium growing
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Bertilsson, Sarah. "Glycanmapping of glycoproteins with UPLC-FLR-MALDI/TOF-MS." Thesis, Uppsala universitet, Analytisk kemi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-228040.

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27

Wyatt, Mark Francis. "Analysis of acrylic polymers by MALDI-TOF mass spectrometry." Thesis, Durham University, 2001. http://etheses.dur.ac.uk/3962/.

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Poly(methyl methacrylate) (PMMA) homopolymers synthesised using 'classical' anionic methods and subsequently studied by matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry (MALDI-TOF-MS) are discussed. Specifically, the attempts at different end-group functionalisation reactions, their varying degrees of success, and the characterisation of these functionalized polymers via MALDI are reported. Extra peaks were observed in the spectra of samples containing a tertiary amine end-group. A mechanism for the in situ elimination of H(_2)(g) involving these end-groups, which w
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28

Sandonato, Beatriz Brabetz. "Peptídeos cíclicos hepatotóxicos : MALDI-TOF como uma ferramenta analítica /." Rio Claro, 2014. http://hdl.handle.net/11449/123921.

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Orientador: Humberto Márcio Santos Milagre<br>Banca: Paulo José Samenho Moran<br>Banca: José Augusto Rosário Rodrigues<br>Resumo: As cianobactérias são bactérias fotossintetizantes que podem ser encontradas nos mais variados ambientes. Algumas espécies de cianobactérias produzem toxinas denominadas cianotoxinas. As cianotoxinas denominadas microcistinas (MCs) são heptapeptídeos cíclicos hepatotóxicos produzidas durante florações de cianobactérias. Sua detecção e quantificação em mananciais são de grande importância devido aos danos a saúde humana que essas microcistinas podem causar. Atualment
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29

Dempwolf, Wibke. "MALDI-TOF in der kontrollierten radikalischen Polymerisation und Präpolymeranalyse." Clausthal-Zellerfeld Papierflieger, 2007. http://d-nb.info/990376834/04.

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30

Schürch, Stefan. "Analytik biologischer und synthetischer Polymere mittels MALDI-TOF Massenspektrometrie /." [S.l.] : [s.n.], 1995. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.

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31

Siricord, Cornelia Charito. "Detection of Phytophthora species by MALDI-TOF mass spectrometry." Thesis, Siricord, Cornelia Charito (2005) Detection of Phytophthora species by MALDI-TOF mass spectrometry. PhD thesis, Murdoch University, 2005. https://researchrepository.murdoch.edu.au/id/eprint/314/.

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Phytophthora diseases have caused worldwide economic, social and environmental impacts for decades. Once their presence is confirmed, they are difficult to eradicate. To reduce and manage the damage inflicted by the pathogen, fast and reliable disease management protocols are required. Tests that enable the rapid and reliable identification of the pathogen assist greatly in disease management. Phytophthora species are traditionally not only detected by baiting but also by plating of symptomatic tissue on selective media. Species can be identified by the characteristics of the mycelium growi
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32

Siricord, Cornelia Charito. "Detection of Phytophthora species by MALDI-TOF mass spectrometry." Siricord, Cornelia Charito (2005) Detection of Phytophthora species by MALDI-TOF mass spectrometry. PhD thesis, Murdoch University, 2005. http://researchrepository.murdoch.edu.au/314/.

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Phytophthora diseases have caused worldwide economic, social and environmental impacts for decades. Once their presence is confirmed, they are difficult to eradicate. To reduce and manage the damage inflicted by the pathogen, fast and reliable disease management protocols are required. Tests that enable the rapid and reliable identification of the pathogen assist greatly in disease management. Phytophthora species are traditionally not only detected by baiting but also by plating of symptomatic tissue on selective media. Species can be identified by the characteristics of the mycelium growi
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33

Borsani, M. "BIOINFORMATICS APPROACHES TO MALDI-TOF MASS SPECTROMETRY DATA ANALYSIS." Doctoral thesis, Università degli Studi di Milano, 2013. http://hdl.handle.net/2434/221050.

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Despite the increasing performance of Mass spectrometry (MS) and others analytical tools, only few biomarkers have been validated and proved to be robust and clinically relevant; indeed a large numbers of proteomic biomarkers have been described, but they are not yet clinical implemented [1]. MALDI-TOF MS seems one of the more powerful tool for biomarkers discovery [2, 3], and shows interesting clinical properties, for instance the possibility to directly search in peripheral fuids for proteins related to an altered physiological state: samples (urine, plasma, serum, etc.) can be collected eas
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34

Olafsson, Jonas. "Antimicrobial Susceptibility Testing Directly from Urine Samples : a Comparison between Standardised and Direct Disk Diffusion Testing together with Direct Species Identification using Matrix Assisted Laser Desorption/Ionisation Time of Flight." Thesis, Linnéuniversitetet, Institutionen för naturvetenskap, NV, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-27645.

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Urinary tract infection (UTI) is a very common infection in humans and a majority is caused by Escherichia coli. UTI are commonly treated empirically. However, empiric treatment has become more problematic due to increased antibiotic resistance to commonly used antibiotic agents. It is therefore desirable with short turnover times for antimicrobial susceptibility testing and species identification to improve antibiotic treatment at an early stage. Matrix Assisted Laser Desorption/Ionisation Time of Flight (MALDI-TOF) can provide species identification faster than former routine methods. This s
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Lourenço, Tarcísio Torre. "Estudo proteômico do desenvolvimento folicular de vacas zebuinas não gestantes." Botucatu, 2016. http://hdl.handle.net/11449/146671.

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Orientador: Fabiana Ferreira de Souza<br>Resumo: O ciclo estral da vaca é composto por 2-3 ondas de crescimento folicular, no qual vários folículos são recrutados e iniciam um novo crescimento. Durante o período denominado desvio folicular, um folículo se torna dominante e os outros entram em atresia. Este processo envolve um mecanismo ainda não completamente compreendido, incluindo proteínas específico, como já estabelecido pela expressão gênica. O objetivo do presente estudo foi caracterizar as proteínas do fluído folicular a fim de identificar macromoléculas relacionadas ao desenvolvimento
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Glückmann, Matthias. "Untersuchungen zur Ablation und Ionenbildung bei matrixunterstützter Laserdesorption-Ionisation (MALDI)." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=963583107.

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Priyasantha, Kandalama KD. "DEVELOPMENT OF A NOVEL MATRIX ASSISTED LASER DESORPTION / IONIZATION (MALDI) BASED PEPTIDE QUANTITATION APPROACH." OpenSIUC, 2015. https://opensiuc.lib.siu.edu/dissertations/989.

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Matrix Assisted Laser Desorption / Ionization (MALDI) Mass Spectrometry (MS) has emerged as an important tool in the field of proteomics mainly because it is simple, quick and efficient. The identification and quantitation of biomarkers, protein targets for drugs, and metabolites are some of the important fields in proteomics research. Although MALDI MS is an important tool in proteomics research there are drawbacks of the technique that need further development in order for the approach to be used in clinical laboratories. One major limitation of MALDI MS is the generally poor reproducibility
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38

Crank, Jeffrey Aaron. "Ionic liquids MALDI-MS matrices and gas chromatography stationary phases /." [Ames, Iowa : Iowa State University], 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3379180.

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39

Przybilla, Laurence. "Methodische Entwicklung der MALDI-TOF-Massenspektrometrie für Grenzbereiche der Polymeranalytik." [S.l. : s.n.], 2000. http://ArchiMeD.uni-mainz.de/pub/2000/0091/diss.pdf.

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Trimpin, Sarah. "Methodische Entwicklung der MALDI-TOF-Massenspektrometrie für Grenzbereiche der Makromolekülanalytik." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=971568650.

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41

Hellwig, Nils [Verfasser]. "Das Laserablationsverhalten von ionischen Flüssigkeiten verschiedener MALDI-Matrices / Nils Hellwig." Kiel : Universitätsbibliothek Kiel, 2012. http://d-nb.info/1025465121/34.

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42

Allwood, Daniel Anthony. "Characterisation and ionisation modelling of matrices in MALDI mass spectrometry." Thesis, University of Hull, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301477.

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43

Schumacher, Joshua. "Carbon Nanotube Enhanced MALDI MS: Increasing Sensitivity Through Sample Concentration." Scholar Commons, 2010. http://scholarcommons.usf.edu/etd/3595.

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Matrix-assisted laser desorption/ionization (MALDI) is a technique used in mass spectrometry for the ionization of biomolecules. A matrix solution is mixed with the analyte molecules to be investigated, and then spotted onto a specialized MALDI plate. The solvents evaporate leaving only the re-crystallized matrix with analyte dispersed throughout the crystals. Sample ionization is accomplished with a laser in the MALDI instrument. The spot diameter of the target is usually several orders of magnitude larger than the diameter of the laser, making it necessary to perform multiple laser investiga
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44

Worster, Belinda Mary. "MALDI-TOF-MS and neuropeptide signalling in the nervous system." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360682.

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45

Steven, Rory Thomas. "Investigations in MALDI-MSI using a high repetition rate laser." Thesis, University of Birmingham, 2014. http://etheses.bham.ac.uk//id/eprint/5392/.

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Within these studies the properties of a high repetition rate (≤ 25,000 Hz) Nd:YVO4 laser were investigated with a view to improving the throughput and quality of information obtained from MALDI MS data collected in continuous raster sampling mode. Initially, the nature of the laser beam profile was investigated and a novel fluorometric method developed for imaging these profiles. Analysis of thin film samples of α-cyano-4-hydroxycinnamic acid (CHCA) and lipid standard phophatidylcholine (PC) 34:1 were carried out. Under most conditions a lower repetition rate and slow stage raster speed were
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46

Guan, Bing. "Characterization of Oligosaccharides and Nanoparticles by MALDI-TOF Mass Spectrometry." ScholarWorks@UNO, 2007. http://scholarworks.uno.edu/td/585.

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The possibilities of differentiating linkage positions and anomeric configurations of small oligosaccharides by negative ion mode MALDI using anion attachment followed by PSD are investigated. By careful initial adjustment of the focusing mirror ratios allowing acquisition of the peaks of interest within the same PSD segment, it is possible to obtain highly reproducible relative ion abundances. Discrimination of different linkage types is achieved by analysis of structurally-informative diagnostic peaks offered by PSD spectra of chloride adducts of oligosaccharides, whereas the relative peak i
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47

Börjesson, Erik. "Undersökning av jonvätskematrisers detektion på olika typer av MALDI plattor." Thesis, KTH, Skolan för kemivetenskap (CHE), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-195847.

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Examensarbetet gjordes för att undersöka om det istället för 2,5-dihydroxidbensoesyra fanns en jonvätskematris som hade en lika bra eller bättre detektionsgrad. Examensarbetet undersökte också om det var någon detektions skillnad på stål- och koncentrationsplatta när analysmetoden matris-assisterande laser desorption-jonisation-masspektrometri (MALDI-MS) analysmetod används. Jonvätskematris är en matris som binder till en svag bas och är till för att skydda peptiderna från addukter. Baserna som undersöktes var etylamin, dietylamin, diisopropylamin och N,N-etyl-diisopropylamin. Examensarbetet j
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Bronzel, Júnior João Luiz [UNESP]. "Matrizes iônicas: detecção e quantificação de cianotoxinas por maldi-ms." Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/143001.

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Made available in DSpace on 2016-08-12T18:48:46Z (GMT). No. of bitstreams: 0 Previous issue date: 2015-08-06. Added 1 bitstream(s) on 2016-08-12T18:51:01Z : No. of bitstreams: 1 000854199.pdf: 5245942 bytes, checksum: 78603c065ca6ba2cb04fe0531fde9643 (MD5)<br>A técnica de ionização MALDI (Matrix-Assisted Laser Desorption/Ionization) foi uma das responsáveis por revolucionar a Espectrometria de Massas, tornando possível sua aplicação a moléculas termolábeis e de alta massa molecular, como as proteínas. Apesar de seu grande desenvolvimento, esta técnica ainda apresenta algumas limitações como
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49

Bronzel, Júnior João Luiz. "Matrizes iônicas : detecção e quantificação de cianotoxinas por maldi-ms /." Araraquara, 2015. http://hdl.handle.net/11449/143001.

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Orientador: Humberto Márcio Santos Milagre<br>Banca: Eduardo Maffud Cilli<br>Banca: José Augusto Rosário Rodrigues<br>Resumo: A técnica de ionização MALDI (Matrix-Assisted Laser Desorption/Ionization) foi uma das responsáveis por revolucionar a Espectrometria de Massas, tornando possível sua aplicação a moléculas termolábeis e de alta massa molecular, como as proteínas. Apesar de seu grande desenvolvimento, esta técnica ainda apresenta algumas limitações como a seleção da matriz utilizada e o método de preparo de amostras. Estes fatores são determinantes na reprodutibilidade da análise e na fa
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50

Earnshaw, Caroline Jane. "Sample preparation methodologies for MALDI-MS imaging and related topics." Thesis, Sheffield Hallam University, 2009. http://shura.shu.ac.uk/19590/.

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The diverse applications of MALDI MSI are explored in this thesis with an emphasis on the sample preparation procedure and method development for small molecule analysis for a range of samples. The two main themes that have been focussed on are the pharmaceutical and metabolomic applications of this state of the art technique. MALDI MSI has been evaluated as a technique for the detection and imaging of antiasthmatic compounds in lung tissue. Four compounds were assessed initially with conventional MALDI MS experiments, followed by both direct and indirect tissue imaging experiments. Pharmaceut
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