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1
Walsh, Kate, Clare A. McCormack, Rachel Webster, Anita Pinto, Seonjoo Lee, Tianshu Feng, H. Sloan Krakovsky, et al. "Maternal prenatal stress phenotypes associate with fetal neurodevelopment and birth outcomes." Proceedings of the National Academy of Sciences 116, no. 48 (October 14, 2019): 23996–4005. http://dx.doi.org/10.1073/pnas.1905890116.
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Maternal prenatal stress influences offspring neurodevelopment and birth outcomes including the ratio of males to females born; however, there is limited understanding of what types of stress matter, and for whom. Using a data-driven approach with 27 variables from questionnaires, ambulatory diaries, and physical assessments collected early in the singleton pregnancies of 187 women, 3 latent profiles of maternal prenatal stress emerged that were differentially associated with sex at birth, birth outcomes, and fetal neurodevelopment. Most women (66.8%) were in the healthy group (HG); 17.1% were in the psychologically stressed group (PSYG), evidencing clinically meaningful elevations in perceived stress, depression, and anxiety; and 16% were in the physically stressed group (PHSG) with relatively higher ambulatory blood pressure and increased caloric intake. The population normative male:female secondary sex ratio (105:100) was lower in the PSYG (2:3) and PHSG (4:9), and higher in the HG (23:18), consistent with research showing diminished male births in maternal stress contexts. PHSG versus HG infants were born 1.5 wk earlier (P < 0.05) with 22% compared to 5% born preterm. PHSG versus HG fetuses had decreased fetal heart rate–movement coupling (P < 0.05), which may indicate slower central nervous system development, and PSYG versus PHSG fetuses had more birth complications, consistent with previous findings among offspring of women with psychiatric illness. Social support most strongly differentiated the HG, PSYG, and PHSG groups, and higher social support was associated with increased odds of male versus female births. Stress phenotypes in pregnant women are associated with male vulnerability and poor fetal outcomes.
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Vanderlaan, Doug P., Ray Blanchard, Kenneth J. Zucker, Raffael Massuda, Anna Martha Vaitses Fontanari, André Oliveira Borba, Angelo Bradelli Costa, et al. "BIRTH ORDER AND ANDROPHILIC MALE-TO-FEMALE TRANSSEXUALISM IN BRAZIL." Journal of Biosocial Science 49, no. 4 (November 7, 2016): 527–35. http://dx.doi.org/10.1017/s0021932016000584.
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SummaryPrevious research has indicated that biological older brothers increase the odds of androphilia in males. This finding has been termed thefraternal birth order effect. Thematernal immune hypothesissuggests that this effect reflects the progressive immunization of some mothers to male-specific antigens involved in fetal male brain masculinization. Exposure to these antigens, as a result of carrying earlier-born sons, is hypothesized to produce maternal immune responses towards later-born sons, thus leading to female-typical neural development of brain regions underlying sexual orientation. Because this hypothesis posits mechanisms that have the potential to be active in any situation where a mother gestates repeated male fetuses, a key prediction is that the fraternal birth order effect should be observable in diverse populations. The present study assessed the association between sexual orientation and birth order in androphilic male-to-female transsexuals in Brazil, a previously unexamined population. Male-to-female transsexuals who reported attraction to males were recruited from a specialty gender identity service in southern Brazil (n=118) and a comparison group of gynephilic non-transsexual men (n=143) was recruited at the same hospital. Logistic regression showed that the transsexual group had significantly more older brothers and other siblings. These effects were independent of one another and consistent with previous studies of birth order and male sexual orientation. The presence of the fraternal birth order effect in the present sample provides further evidence of the ubiquity of this effect and, therefore, lends support to the maternal immune hypothesis as an explanation of androphilic sexual orientation in some male-to-female transsexuals.
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Edvardsson, Kristina, Mary-Ann Davey, Rhonda Powell, and Anna Axmon. "Sex ratios at birth in Australia according to mother’s country of birth: A national study of all 5 614 847 reported live births 1997–2016." PLOS ONE 16, no. 6 (June 25, 2021): e0251588. http://dx.doi.org/10.1371/journal.pone.0251588.
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Objectives Son preference and sex selective practices have resulted in a deficit of girls in several countries, primarily across Asia. Emerging evidence indicates that son preference survives migration to Western high-income countries. The objective of this study was to assess male-to-female (M/F) ratios at birth per mother’s country of birth in Australia 1997–2016, in total and by parity, and by states/territories and over time. Methods Data for this national population-based cross-sectional study were obtained from the National Perinatal Data Collection (NPDC) and included all live births in Australia 1997–2016 (N = 5 614 847). M/F ratios with 95% Confidence Intervals were estimated. Results The M/F ratio for births to Australian-born mothers was within the expected range (1.03–1.07) regardless of parity and time period. M/F ratios were elevated above the expected range for births to mothers born in China in the total sample (M/F ratio 1.084, 95% confidence interval 1.071–1.097) and at parity 2 (1.175, 1.120–1.231), and for births to mothers born in India at parity 2 (1.146, 1.090–1.204). Parity 2 births were the most consistently male-biased across time. Across states, elevated M/F ratios were identified for both groups in New South Wales (China parity 2: 1.182, 1.108–1.260; India parity 2: 1.182, 1.088–1.285), for births to Chinese-born mothers in Victoria (total births: 1.097, 1.072–1.123; parity 1: 1.115, 1.072–1.159) and Australian Capital Territory (total births: 1.189, 1.085–1.302) and births to Indian-born mothers Western Australia (parity 2: 1.307, 1.122–1.523). Conclusions Son preference persists in some immigrant communities after migration to Australia. The consistent pattern of elevated M/F ratios across the larger states indicates that sex imbalances at birth are largely independent of restrictiveness of local abortion laws. Drivers and consequences of son preference in Western high-income settings should be explored to further promote gender equality, and to strengthen support for women who may be vulnerable to reproductive coercion.
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Fellman, Johan, and Aldur W. Eriksson. "Sex Ratio in Sibships With Twins." Twin Research and Human Genetics 11, no. 2 (April 1, 2008): 204–14. http://dx.doi.org/10.1375/twin.11.2.204.
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AbstractIn national birth registers of Caucasians, the secondary sex ratio, that is, the number of boys per 100 girls at birth, is almost constant at 106. Variations other than random variation have been noted, and attention is being paid to identifying presumptive influential factors. Studies of the influence of different factors have, however, yielded meagre results. An effective means of identifying discrepancies is to investigate birth data compiled into sibships of different sizes. Assuming no inter- or intra-maternal variations, the distributions of the sex composition are binomial. Varying parental tendencies for a specific sex result in discrepancies from the binomial distribution. Over a century ago, the German scientists Geissler and Lommatzsch analyzed the vital statistics of Saxony, including twin maternities, for the last quarter of the 19th century. They considered sibships ending with twin sets. Their hypothesis was that in sibships ending with male–male twin pairs, the sex ratio among previous births is higher than normal, while in sibships with female–female twin pairs, the sex ratio is lower than normal. If the sibship ended with a male-female pair, then the sex ratio is almost normal. Consequently, a same-sex twin set indicated, in general, deviations in the sex ratio among the sibs within the sibship. Our analyzes of their data yielded statistically significant results that support their statements.
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McCann, Stewart J. H. "Birth Order of past Presidents and Schlesinger's History Cycles: Support for Stewart's Leadership Theory." Psychological Reports 88, no. 2 (April 2001): 375–76. http://dx.doi.org/10.2466/pr0.2001.88.2.375.
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Stewart's hypothesis (1992) that adults who were only-children and first-born children are most suited to lead communities in more turbulent times while adults who were later-born children are most suited to lead in more tranquil times was tested by relating the male birth order of elected presidents to Schlesinger's 1986 public purpose and private interest periods. Consistent with Stewart's hypothesis, candidates who were only-children and first-born children tended to win during public purpose phases, which are characterized by the turbulence of greater political commitment, idealism, and broad social change.
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Chittle, Laura, Sean Horton, Patricia Weir, and Jess C. Dixon. "Investigating the relationship between the relative age effect and leadership behaviors among male ice hockey players." International Review for the Sociology of Sport 52, no. 6 (November 30, 2015): 751–68. http://dx.doi.org/10.1177/1012690215616271.
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This study examined the role of relative age on leadership behaviors among male house league ice hockey players. Athletes completed an online survey that solicited their birthdate along with their responses to the leadership scale for sport. As expected, the results of our analyses revealed no relative age effects. Captains scored significantly higher on the training and instruction, democratic behavior and social support dimensions of the leadership scale for sport. While there were significant multivariate differences between birth quartile and the dimensions of leadership, a relative weight analysis revealed that quartile of birth did not differ significantly on any of these dimensions. Thus, male house league hockey players are not (dis)advantaged in terms of their leadership behaviors as a consequence of relative age.
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Phillips, Gregory, Anand Raman, Dylan Felt, Ying Han, and Brian Mustanski. "Factors Associated with PrEP Support and Disclosure Among YMSM and Transgender Individuals Assigned Male at Birth in Chicago." AIDS and Behavior 23, no. 10 (June 21, 2019): 2749–60. http://dx.doi.org/10.1007/s10461-019-02561-1.
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Blanchard, Ray, Jurian Krupp, Doug P. VanderLaan, Paul L. Vasey, and Kenneth J. Zucker. "A method yielding comparable estimates of the fraternal birth order and female fecundity effects in male homosexuality." Proceedings of the Royal Society B: Biological Sciences 287, no. 1923 (March 18, 2020): 20192907. http://dx.doi.org/10.1098/rspb.2019.2907.
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The fraternal birth order effect (FBOE) is the finding that older brothers increase the probability of homosexuality in later-born males, and the female fecundity effect (FFE) is the finding that the mothers of homosexual males produce more offspring than the mothers of heterosexual males. In a recent paper, Khovanova proposed a novel method for computing independent estimates of these effects on the same samples and expressing the magnitude and direction of the effects in the same metric. In her procedure, only families with one or two sons are examined, and daughters are ignored. The present study investigated the performance of Khovanova's method using archived data from 10 studies, comprising 14 samples totalling 5390 homosexual and heterosexual subjects. The effect estimate for the FBOE showed that an increase from zero older brothers to one older brother is associated with a 38% increase in the odds of homosexuality. By contrast, the effect estimate for the FFE showed that the increase from zero younger brothers to one younger brother is not associated with any increase in the odds of homosexuality. The former result supports the maternal immune hypothesis of male homosexuality; the latter result does not support the balancing selection hypothesis.
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Kim, Joeun, and Nancy Luke. "Lowest-Low Fertility in South Korea: Policy and Domestic Labor Supports and the Transition to Second Birth." Social Forces 99, no. 2 (April 30, 2020): 700–731. http://dx.doi.org/10.1093/sf/soz159.
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Abstract Scholars and policymakers contend that severe work-family constraints for women are a key contributor to lowest-low fertility in industrialized countries. Two separate areas of research have examined supports that could alleviate these constraints and potentially increase fertility: institutional support in the form of public policies and domestic labor support from male partners. There are few studies considering the influence of both policy and domestic labor supports and no investigations of the interplay between these two support mechanisms. We develop and test a theoretical framework that considers how the combination of these supports could alleviate women’s work-family constraints and increase fertility. Using the case of South Korea, a country with one of the most sustained lowest-low fertility rates in history, we examined the relationship between women’s eligibility for parental leave and husbands’ share of domestic labor and the transition to a second birth. Our analyses revealed that both supports, independently, had positive effects on the likelihood of a second birth. More importantly, we found that husbands’ domestic labor had a positive influence on fertility only when women’s access to parental leave was limited, suggesting that policy and domestic labor supports are substitutes and alleviate the same underlying work-family constraint in the Korean context. Our study underscores the importance of understanding the nature of work-family conflict across countries and how various supports―alone or in combination―could relieve women’s constraints on childbearing and upturn lowest-low fertility.
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Jose, Cristina San, Francisco Braza, and Xenia Casanova. "Reproductive Status of Mothers Affects Sex-Biased Parental Investment in Humans." Perceptual and Motor Skills 85, no. 3 (December 1997): 917–18. http://dx.doi.org/10.2466/pms.1997.85.3.917.
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An analysis of the sexual differences in birth weights of 381 children showed that boys are heavier than girls for multiparous mothers but not for primiparous ones. The results support the current hypotheses that predict sex biases in parental investment, with higher costs of producing male offspring in some mammals.
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Shibukawa, Bianca Machado Cruz, Gabrieli Patricio Rissi, Ieda Harumi Higarashi, and Rosana Rosseto de Oliveira. "Factors associated with the presence of cleft lip and / or cleft palate in Brazilian newborns." Revista Brasileira de Saúde Materno Infantil 19, no. 4 (December 2019): 947–56. http://dx.doi.org/10.1590/1806-93042019000400012.
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Abstract Objectives: to analyze the trend and the associated factors with the presence of cleft lip and/or cleft palate in Brazilian newborns, in order to verify possible associations with maternal care and newborn factors. Methods: a cross-sectional and ecological study, involving all live births in Brazil, recorded in the Information System on Live Births from 2005 to 2016. Maternal and infant information were evaluated using trend analysis and odds ratio, with a 95% confidence interval. The analyses were performed using SPSS software. Results: we analyzed 17,800 live births with presence of cleft lip and/or cleft palate. The Brazilian prevalence rate was 0.51 / 1000 live births, with South and Southeast Regions registering higher rates than the national rate. There was an association with maternal age above 35 years old, with no partner, less than seven prenatal consultations, premature birth and cesarean section. About the factors of the newborn, being male, Apgar less than seven in the 1st and 5th minutes of life, low birth weight and white color were associated. Conclusions: Brazil has an increasing tendency for cleft lip and/or cleft palate (p=0.019), reinforcing the need to strengthen health care networks, providing adequate support for newborn with cleft lip and/or cleft palate and their families.
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Osler, Merete, Merete Nordentoft, and Anne-Marie Nybo Andersen. "Birth dimensions and risk of depression in adulthood: cohort study of Danish men born in 1953." British Journal of Psychiatry 186, no. 5 (May 2005): 400–403. http://dx.doi.org/10.1192/bjp.186.5.400.
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BackgroundTwo British cohort studies have reported birth weight to be associated with self-reported depression in adulthood, even after adjustment for socio-economic factors.AimsTo examine the relationship between birth dimensions and discharge from a psychiatric ward with a depression diagnosis in adulthood.MethodA cohort of 10 753 male singletons born in Copenhagen, Denmark in 1953 and for whom birth certificates had been traced in 1965 were followed from 1969 until 2002, with record linkage for date of first admission to a psychiatric ward that led to a discharge diagnosis of depression.ResultsA total of 190 men, corresponding to 1.8% of the cohort, had a discharge diagnosis of depression. The Cox's regression analyses failed to show any association between birth dimensions (birth weight and ponderal index) and risk of psychiatric ward diagnosis of depression in adult life, before or after adjustment for social indicators at birth.ConclusionsThis study does not support the existence of a relation between birth dimensions and psychiatric ward admission for depression in adult men.
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Steinhardt, M., and H. H. Thielscher. "Schilddrüsenhormone bei Milchrindern in Laufstallhaltung nach der Kalbung und bei deren Kälbern. Effekte einiger konstanter und variabler Faktoren." Archives Animal Breeding 48, no. 3 (October 10, 2005): 247–60. http://dx.doi.org/10.5194/aab-48-247-2005.
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Abstract. Title of the paper: Thyroid hormones in loose housed dairy cattle and in their newborn calves. Effects of some constant and variable factors On dairy cows (72 German Holstein Friesian, 8 German Red Pied, kept loose house) and on their newborn calves thyroid hormone and body temperature measurements and in calves body weight measurements were done and analysed considering lactation number and gestation length of the dam, sex and body weight of the calf, type of birth, daytime of birth and measurement. For gestation length, body weight and lactation number no effects on thyroid hormones could be found. Birth course was specified as GV1 (without assistance), GV2 (with little assistance by the herdsman, in some cases with mechanical support), and GV3 (with heavy traction, most with mechanical support). In GV2 the number of male calves was twice that of female calves. Sex of calf influenced effects of birth type in case of T4 and body temperature of the dam and effects of pH group in case of FT3 of the calf. Calves born without any support had significant greater T4, FT4 and FT3 concentrations than those with GV 2 and GV 3. Assisted birth types were significantly more frequent in pH groups pHG3 and pHG4 than in groups pHG1 and pHG2. In calves thyroid hormones had significant correlations with pCO2 and pH of calf venous blood and with the time elapsing between birth and sampling. In dams of group GV3 the means of FT4 and T4 were smaller than those in dams of GV1 and GV2 but this differences were not significant.
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Gocen, Ugur, Atakan Atalay, and Orhan Kemal Salih. "A Case of Neonatal Heart Failure Caused by Left Ventricular Diverticulum: Successful ECMO Support Application." Heart Surgery Forum 19, no. 4 (August 23, 2016): 189. http://dx.doi.org/10.1532/hsf.1530.
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Congenital left ventricular diverticulum is a rare cardiac anomaly. During the newborn period, symptomatic patients are diagnosed with heart failure findings. We present a 23-day-old male newborn with congenital left ventricular diverticulum diagnosed during fetal echocardiographic examination. After the birth, the patient had heart failure symptoms and his echocardiographic examination showed low cardiac ejection fraction. Diverticulum was operated with endoventricular circular patch plasty (DOR) technique, and after, cardiopulmonary bypass venoarterial extracorporeal membrane oxygenation (ECMO) support was performed because of low cardiac output syndrome. On postoperative day 17, he was discharged with no problem.
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Bilezikian, John P. "The role of estrogens in male skeletal development." Reproduction, Fertility and Development 13, no. 4 (2001): 253. http://dx.doi.org/10.1071/rd00120.
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The developing human skeleton is known to be influenced by the presence of sex steroids. In girls, estrogens have been considered to be the dominant hormone, whereas in boys, androgens have occupied a primary physiological role in terms of bone mass accrual. Although these views are still current, recent observations made of rare defects in estrogen receptor sensitivity or estrogen synthesis have called attention to the importance of estrogens in the developing male skeleton. In these human genetic models, the affected men have demonstrated continuous linear skeletal growth, open epiphyses, lack of pubertal growth spurt, and reduced bone mass. In the example of men with aromatase deficiency, lacking estrogens from birth, administration of estrogen led to impressive increases in bone density, maturation of the skeletal growth plates, and cessation of linear growth. Animal models mimicking these human syndromes by knockout technology, have tended to support these observations. The data argue for a primary role of estrogens in the developing male skeleton, while not diminishing the important role for androgens.
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Catalano, Ralph A., Katherine B. Saxton, Alison Gemmill, and Terry Hartig. "Twinning in Norway Following the Oslo Massacre: Evidence of a ‘Bruce Effect’ in Humans." Twin Research and Human Genetics 19, no. 5 (July 25, 2016): 485–91. http://dx.doi.org/10.1017/thg.2016.58.
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Emerging theory and empirical work suggest that the ‘Bruce Effect’, or the increase in spontaneous abortion observed in non-human species when environments become threatening to offspring survival, may also appear in humans. We argue that, if it does, the effect would appear in the odds of twins among male and female live births. We test the hypothesis, implied by our argument, that the odds of a twin among male infants in Norway fell below, while those among females rose above, expected levels among birth cohorts in gestation in July 2011 when a deranged man murdered 77 Norwegians, including many youths. Results support the hypothesis and imply that the Bruce Effect operates in women to autonomically raise the standard of fetal fitness necessary to extend the gestation of twins. This circumstance has implications for using twins to estimate the relative contributions of genes and environment to human responses to exogenous stimuli.
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Linklater, W. L. "Translocation reverses birth sex ratio bias depending on its timing during gestation: evidence for the action of two sex-allocation mechanisms." Reproduction, Fertility and Development 19, no. 7 (2007): 831. http://dx.doi.org/10.1071/rd07027.
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Many sex allocation mechanisms are proposed but rarely have researchers considered and tested more than one at a time. Four facultative birth sex ratio (BSR) adjustment mechanisms are considered: (1) hormone-induced conception bias; (2) sex-differential embryo death from excess glucose metabolism; (3) sex-differential embryo death from embryo–uterine developmental asynchrony; and (4) pregnancy hormone suppression and resource deprivation. All mechanisms could be switched on by the corticoadrenal stress response. A total of 104 female rhinoceroses (Rhinocerotidae), translocated from 1961 to 2004 at different stages of gestation or conceived soon after arrival in captivity, were used to test for a reversal in BSR bias as evidence for the action of multiple sex-allocation mechanisms. Translocation induced a statistically significant BSR reversal between early gestation (86% male births from 0 to 0.19 gestation) and mid-gestation (38% male from 0.2 to 0.79 gestation). Captivity also induced a strongly male-biased (67% male) BSR for conceptions after arrival in captivity. The results indicate the action of at least two sex-allocation mechanisms operating in sequence, confirm the important role of sex-differential embryo death around implantation and of stress in sex allocation, and lend support to suggestions that sex-differential glucose metabolism by the preimplantation embryo likely plays a role in facultative BSR adjustment.
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Behie, A. M., and M. H. O’Donnell. "HIGHER PARENTAL PERCEPTIONS OF WEALTH ASSOCIATED WITH THE BIRTH OF MORE SONS IN AN AUSTRALIAN POPULATION." Journal of Biosocial Science 50, no. 4 (September 20, 2017): 569–72. http://dx.doi.org/10.1017/s0021932017000451.
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SummaryMany industrialized nations are currently experiencing a decline in average secondary sex ratio (SSR) resulting in fewer boys being born relative to girls. While many potential factors may explain the decline in the birth of males relative to females, it seems most studies support the idea that male offspring are produced less often when environmental conditions are poor owing to males being more susceptible to loss in harsh environments. This study investigates the maternal factors that are associated with the sex of offspring in a cohort of the Australian population. It found that greater parental perceptions of wealth were significantly associated with an increase in the number of sons produced. These results suggest that male offspring are born at increased numbers to women with higher available resources, which may reflect the fact that male offspring are more vulnerable in poor environments.
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Štimac, Tea, Ana-Maria Šopić-Rahelić, Jelena Ivandić, Eduard Ekinja, and Isaac Blickstein. "Effect of gender on growth-restricted fetuses born preterm." Journal of Perinatal Medicine 47, no. 6 (August 27, 2019): 677–79. http://dx.doi.org/10.1515/jpm-2019-0074.
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Abstract Objective To assess the effect of fetal gender in small-for-gestational age (SGA) neonates with birth weight less than the fifth percentile by gestational age. Methods We compared male and female SGA neonates for maternal and neonatal outcomes in the following gestational age subgroups: at <32 + 6, 33 + 0–36 + 6 and at ≥37 + 0 weeks of gestation. Results We examined 159, 154 and 2363 SGA neonates born at <32 + 6, 33 + 0 to 36 + 6 and ≥37 weeks of pregnancy, respectively, whose birth weight was below the fifth percentile for gestational age and who met our inclusion criteria. Overall, there were no significant differences between the mothers of males and females, except that there were more males at term and the incidence of nulliparas was greater among the mothers of males. In terms of outcomes, males had a similar incidence of respiratory distress syndrome (RDS), intraventricular hemorrhage (IVH) and admissions to intensive care. Interestingly, low Apgar scores were more common in preterm females born at 33–37 weeks and vice versa in births over 37 weeks. Conclusion Our data do not support an advantage of either gender in preterm birth of infants who are most likely growth restricted.
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Vaamonde, D., A. C. Hackney, J. M. Garcia Manso, E. Arriaza Ardiles, and M. Vaquero. "Birth sex ratio in the offspring of professional male soccer players: influence of exercise training load." Human Reproduction 35, no. 11 (October 2, 2020): 2613–18. http://dx.doi.org/10.1093/humrep/deaa225.
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Abstract STUDY QUESTION Can the exercise training load of elite male athletes influence the sex ratio of their offspring? SUMMARY ANSWER This is the first study assessing the influence of exercise training load on the offspring sex ratio of children from male professional athletes, observing a bias toward more females being born as a result of both high-intensity and high-volume loads, with intensity having the greatest effect. WHAT IS KNOWN ALREADY There is a relatively constant population sex ratio of males to females among various species; however, certain events and circumstances may alter this population sex ratio favoring one sex over the other. STUDY DESIGN, SIZE, DURATION Observational, descriptive cross-sectional study with a duration of 3 months. PARTICIPANTS/MATERIALS, SETTING, METHODS Seventy-five male professional soccer players from First Division soccer teams. Offspring variables were sex of the offspring, number of children and order of birth. Exercise training variables were volume and intensity. MAIN RESULTS AND THE ROLE OF CHANCE Total offspring was 122 children (52 males (42.6%), 70 females (57.4%)). Analysis revealed that increase in either the volume (P < 0.001) or intensity (P < 0.001) of training by the players shifted the birth offspring ratio more toward females. Within the sample of females born, more births (i.e. number) were observed as a consequence of training at the highest intensity (45 out of 70; P < 0.001), no such pattern occurred within males (P > 0.05). When female versus male births were compared within each intensity, only the high-intensity comparison was significant (45 (75%) females vs 15 (25%) males, P < 0.001). LIMITATIONS, REASONS FOR CAUTION While this is the first study assessing differences in the sex ratio of the offspring of male athletes (i.e. soccer players), we acknowledge there are limitations and confounders within our approach; e.g. small sample size, ethnic background and variations in the timing of intercourse relative to ovulation as well as in sex hormone levels. As such, we propose that future research is needed to confirm or refute our findings. It is recommended that such work expand on the measurements obtained and conduct direct assessment of sperm characteristics. WIDER IMPLICATIONS OF THE FINDINGS The findings of the study support the fact that different stressors on the body may alter the sex of the offspring. While in the present study the stressor is the excessive training load of soccer players, other events may lead to similar results. The bias in offspring sex ratio may have important implications for demography and population dynamics, as well as genetic trait inheritance. STUDY FUNDING/COMPETING INTEREST(S) There is no funding nor competing interests. TRIAL REGISTRATION NUMBER N/A
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Hughes-McCormack, Laura Anne, Ruth McGowan, J. P. Pell, Daniel Mackay, Angela Henderson, Lisa O'Leary, and Sally-Ann Cooper. "Birth incidence, deaths and hospitalisations of children and young people with Down syndrome, 1990–2015: birth cohort study." BMJ Open 10, no. 4 (April 2020): e033770. http://dx.doi.org/10.1136/bmjopen-2019-033770.
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ObjectiveTo investigate current Down syndrome live birth and death rates, and childhood hospitalisations, compared with peers.SettingGeneral community.ParticipantsAll live births with Down syndrome, 1990–2015, identified via Scottish regional cytogenetic laboratories, each age–sex–neighbourhood deprivation matched with five non-Down syndrome controls. Record linkage to Scotland’s hospital admissions and death data.Primary outcomeHRs comparing risk of first hospitalisation (any and emergency), readmission for children with Down syndrome and matched controls were calculated using stratified Cox proportional hazards (PH) model, and length of hospital stay was calculated using a conditional log-linear regression model.Results689/1479 (46.6%) female and 769/1479 (51.9%) male children/young people with Down syndrome were identified (1.0/1000 births, with no reduction over time); 1235 were matched. 92/1235 (7.4%) died during the period, 18.5 times more than controls. More of the Down syndrome group had at least one admission (incidence rate ratio(IRR) 72.89 (68.72–77.32) vs 40.51 (39.15–41.92); adjusted HR=1.84 (1.68, 2.01)) and readmissions (IRR 54.85 (51.46–58.46) vs 15.06 (14.36–15.80); adjusted HR=2.56 (2.08, 3.14)). More of their admissions were emergencies (IRR 56.78 (53.13–60.72) vs 28.88 (27.73–30.07); first emergency admission adjusted HR=2.87 (2.61, 3.15)). Children with Down syndrome had 28% longer first admission after birth. Admission rate increased from 1990–2003 to 2004–2014 for the Down syndrome group (from 90.7% to 92.2%) and decreased for controls (from 63.3% to 44.8%).ConclusionsWe provide contemporaneous statistics on the live birth rate of babies with Down syndrome, and their childhood death rate. They require more hospital admissions, readmissions emergency admissions and longer lengths of stays than their peers, which has received scant research attention in the past. This demonstrates the importance of statutory planning as well as informal support to families to avoid added problems in child development and family bonding over and above that brought by the intellectual disabilities associated with Down syndrome.
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Xia, Xuhua, and John S. Millar. "Dispersion of adult male Peromyscus leucopus in relation to female reproductive status." Canadian Journal of Zoology 67, no. 4 (April 1, 1989): 1047–52. http://dx.doi.org/10.1139/z89-145.
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We studied dispersion of adult male Peromyscus leucopus in relation to the stage of pregnancy of adult females in natural populations monitored with Longworth live traps. Because postpartum mating is common in P. leucopus and days to parturition measures how far a female is from her next mating, we predicted that a female in early pregnancy (many days to parturition) would have fewer adult males in her neighbourhood than a female in late pregnancy (few days to parturition). Number of adult males caught within 30 m of each adult female was recorded and number of days to parturition for each female was obtained by bringing females back to the laboratory and allowing them to give birth. A negative relationship was found between number of adult males in a female's neighbourhood and days to parturition of the female (r = −0.419, p < 0.01), with the latter accounting for 8.8% of the variance in the former. These results support the hypothesis of a promiscuous mating system in P. leucopus.
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Marjoribanks, Kevin. "Perceptions of Family Learning Environments: The Influence of Sibling Background." Perceptual and Motor Skills 69, no. 3-1 (December 1989): 955–61. http://dx.doi.org/10.1177/00315125890693-147.
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Longitudinal data from 240 female and 260 male Australians were used to examine relationships among birth order, sibsize, and adolescents’ perceptions of family learning environments after taking into account the correlation of intellectual ability and social status on those perceptions. For the analysis, regression models were investigated that included terms to test for possible linear, interaction and curvilinear relationships. The findings provided tentative support for the sibling dilution theory, that is, after accounting for the effects of children's ability and family social status, the sibling variables continued to have some modest associations with the adolescents’ perceptions of their parents’ support for learning.
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Bruckner, Tim A., Samuli Helle, Elisabeth Bolund, and Virpi Lummaa. "Culled males, infant mortality and reproductive success in a pre-industrial Finnish population." Proceedings of the Royal Society B: Biological Sciences 282, no. 1799 (January 22, 2015): 20140835. http://dx.doi.org/10.1098/rspb.2014.0835.
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Theoretical and empirical literature asserts that the sex ratio (i.e. M/F) at birth gauges the strength of selection in utero and cohort quality of males that survive to birth. We report the first individual-level test in humans, using detailed life-history data, of the ‘culled cohort’ hypothesis that males born to low annual sex ratio cohorts show lower than expected infant mortality and greater than expected lifetime reproductive success. We applied time-series and structural equation methods to a unique multigenerational dataset of a natural fertility population in nineteenth century Finland. We find that, consistent with culled cohorts, a 1 s.d. decline in the annual cohort sex ratio precedes an 8% decrease in the risk of male infant mortality. Males born to lower cohort sex ratios also successfully raised 4% more offspring to reproductive age than did males born to higher cohort sex ratios. The offspring result, however, falls just outside conventional levels of statistical significance. In historical Finland, the cohort sex ratio gauges selection against males in utero and predicts male infant mortality. The reproductive success findings, however, provide weak support for an evolutionarily adaptive explanation of male culling in utero .
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PARRA-BRACAMONTE, G. M., X. F. DE LA ROSA-REYNA, N. TREVIÑO-MARTÍNEZ, W. ARELLANO-VERA, and V. MORENO-MEDINA. "Genetic parameters and non-genetic influences related to birth weight in farmed white-tailed deer." Journal of Agricultural Science 152, no. 3 (September 4, 2013): 497–503. http://dx.doi.org/10.1017/s0021859613000609.
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SUMMARYStudying and understanding the sources of variation in early life traits in farmed deer are fundamental for management and/or breeding purposes. Data from a captive white-tailed deer population were analysed to identify non-genetic and genetic factors affecting the birth weight (BW) of fawns. The year, type of birth and sex were included in a fixed linear model to examine their significance. All of the examined non-genetic factors had a highly significant effect on BW (P<0·001). The examined years showed variation attributed to food availability affecting the gestational conditions of does. Male fawns were 193 g heavier than female fawns at birth (P<0·001), and singleton births were associated with a higher BW (2·97±0·043 kg) compared with twin (−0·261 g) and triplet (−0·642 g) fawning (P<0·001). The best-fitting animal model was selected by comparing reduced and complete models. Based on the selected animal model, which included direct genetic and common maternal effects, genetic components and parameters were estimated. The direct heritability was found to be 0·28±0·126, and a small but important contribution of common maternal environmental effects was identified (c2=0·15±0·062). The results support the importance of certain environmental factors affecting BW and indicate the relevance of direct genetic and maternal environmental influences to sustained genetic changes in BW and positively correlated traits in farmed white-tailed deer populations.
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Berntsen, Sine, Bugge Nøhr, Marie Louise Grøndahl, Morten Rønn Petersen, Lars Franch Andersen, Anne Lis Englund, Ulla Breth Knudsen, et al. "In vitro fertilisation (IVF) versus intracytoplasmic sperm injection (ICSI) in patients without severe male factor infertility: study protocol for the randomised, controlled, multicentre trial INVICSI." BMJ Open 11, no. 6 (June 2021): e051058. http://dx.doi.org/10.1136/bmjopen-2021-051058.
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IntroductionOver the last decades, the use of intracytoplasmic sperm injection (ICSI) has increased, even among patients without male factor infertility. The increase has happened even though there is no evidence to support that ICSI results in higher live birth rates compared with conventional in vitro fertilisation (IVF) in cases with nonmale factor infertility. The lack of robust evidence on an advantage of using ICSI over conventional IVF in these patients is problematic since ICSI is more invasive, complex and requires additional resources, time and effort. Therefore, the primary objective of the IVF versus ICSI (INVICSI) study is to determine whether ICSI is superior to standard IVF in patients without severe male factor infertility. The primary outcome measure is first live birth from fresh and frozen-thawed transfers after one stimulated cycle. Secondary outcomes include fertilisation rate, ongoing pregnancy rate, birth weight and congenital anomalies.Methods and analysisThis is a two-armed, multicentre, randomised, controlled trial. In total, 824 couples/women with infertility without severe male factor will be recruited and allocated randomly into two groups (IVF or ICSI) in a 1:1 ratio. Participants will be randomised in variable block sizes and stratified by trial site and age. The main inclusion criteria are (1) no prior IVF/ICSI treatment, (2) male partner sperm with an expected count of minimum 2 million progressive motile spermatozoa following density gradient purification on the day of oocyte pick up and (3) age of the woman between 18 and 42 years.Ethics and disseminationThe study will be performed in accordance with the ethical principles in the Helsinki Declaration. The study is approved by the Scientific Ethical Committee of the Capital Region of Denmark. Study findings will be presented, irrespectively of results at international conferences and submitted for publication in peer-reviewed journals.Trial registration numberNCT04128904. Pre-results.
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Shrestha, Basundhara, and Dipendra Kumar Yadav. "Gender Differences in Feeding, Care, Support and Nutritional Status of Children in the Rural Area of Kaski District, Nepal." Journal of Health and Allied Sciences 5, no. 1 (November 21, 2019): 44–47. http://dx.doi.org/10.37107/jhas.34.
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The girl child faces the neglect of the family in the form of a failure to provide her the basic necessities of life in terms of food, clothing, love, shelter, supervision, education and medical care. Differential treatment of the boys and girls within families can be attributed to the social religious, cultural and economic returns that sons provide to their parents relative to daughters. Objective of the study was to assess the gender differences in feeding, care, support and nutritional status of children in the rural area of Kaski district, Nepal. A cross sectional study was carried out among the 456 children of 0-23 months from four VDCs of Kaski district. Data were collected using cluster random sampling. After obtaining the oral consent from the mothers and then data were collected in a pre-tested, pre designed, structured questionnaire by interview technique. In this study half of the respondents initiated breast milk within one hour after birth. Among them, more male children were received breast milk than female children. Nearly all (98.7%) of female child were fed colostrums milk. More than half (53.6%) of the respondents (male 54.4% and female 52.9%) were feeding breast milk more than nine times in 24 hours. Higher proportions of male children were exclusively breastfed than female children. Similarly higher percentages of male children were fed complementary food on timely than female children. The frequency of complementary feeding was less than four times for both children. During child illness most of the respondents went to hospital and almost all children got vaccines and vitamin A. Female appeared slightly more likely to be stunted than male. 19.2% male and 13.1% female were underweight and the proportion of wasted were nearly same in both male and female. There were no much differences among both the gender regarding feeding practice, care and support.
Keywords: Gender differences in feeding; Care; Nutritional status of children; Rural area
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Tsang, Eileen Yuk-ha. "A Sisterhood of Hope: How China’s Transgender Sex Workers Cope with Intimate Partner Violence." International Journal of Environmental Research and Public Health 17, no. 21 (October 29, 2020): 7959. http://dx.doi.org/10.3390/ijerph17217959.
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Transgender sex workers (TSWs/TSW) face considerable challenges that affect their mental health and make their situations more vulnerable and precarious. TSWs often experience violence from clients, police, and others, but it is estimated that 50% of these acts of violence are at the hands of their intimate partners. The marginalization of TSWs is fueled by abuse through isolation and shaming which prevents them from seeking help through formal channels like police or counselling services. There is limited research on intimate partner violence (IPV) involving transgender sex workers (biologically male at birth who transition to women) and their partners who are typically heterosexual/bisexual men. In China, stigmatization, homophobia, heterosexism, and transphobia structurally disadvantage TSWs and this power structure tacitly supports violence and abuse against them. To survive, TSWs rely on informal networks with their ‘sisters’ for advice and emotional support which is more effective at combatting IPV than criminal justice or social policy efforts. Ethnographic data from in-depth interviews with 25 TSWs provide insight about IPV and how informal social support is a protective factor that helps them cope with routine acts of violence. The findings identify the importance of the ‘sisterhood’ and how it protects and helps TSWs manage their physical and mental health.
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Shafaq, Najibullah, and Walikhan Oryakhil. "Investigating the birth prevalence of congenital club foot in both Paktya and Kapisa provinces of Afghanistan." International Journal of Research in Orthopaedics 7, no. 2 (February 23, 2021): 264. http://dx.doi.org/10.18203/issn.2455-4510.intjresorthop20210618.
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<p class="abstract"><strong>Background: </strong>congenital talipes equinovarus (CTEV) or Clubfoot is one of the most common birth defects of the musculoskeletal system and affects 1 in every 1000 live births each year that cause mobility impairment. The purpose of this study is to investigating the birth prevalence of congenital club foot in both paktya and kapisa provinces of Afghanistan.</p><p class="abstract"><strong>Methods: </strong>This study is descriptive and cross-sectional that is done on all live birth babies in a one-year period in the Paktya regional hospital (paktya province) and Alberoni teaching hospital (kapisa province) of Afghanistan from September 2019 to September 2020 and in this study, all ethical considerations were considered. The variables that were examined in our study included the following: type of delivery, mother age, gender and birth weight of the baby, newborn legs were photographed on the first day of birth and evaluated by an orthopedic surgeon. Finally, statistical data were analyze by using SPSS software</p><p class="abstract"><strong>Results:</strong> In this study 35 cases of multiple births including 33 cases of twins and 2 cases of triplets were recorded and the rate of cesarean section was 5.96% in this group and data showed 99.65% of infant with no congenital talipes equinovarus or club foot abnormalities Subsequently, 0.35% or 36 people had congenital clubfoot which it had more incidence in male and bilateral form was more common.</p><p class="abstract"><strong>Conclusions: </strong>Based on the results of our study we found that prevalence of clubfoot is about 3.5 per 1000 live birth similar to other low-income country which it’s rate was more. Because diagnosis and treatment of clubfoot in the early stages is more possible Therefore, timely recognition, diagnosis and treatment are significant and helpful to decrease medical expenses. Our result in this study support high prevalence of clubfoot anomaly in mentioned provinces of Afghanistan because of different genetic and environmental risk factor to provide practical suggestions we need more epidemiologic study in all over the Afghanistan to find them.</p>
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Saalfeld, Sarah T., Stephen S. Ditchkoff, John J. Ozoga, and Michael S. Mitchell. "Seasonal Variation in Sex Ratios Provides Developmental Advantages in White-tailed Deer, Odocoileus virginianus." Canadian Field-Naturalist 121, no. 4 (October 1, 2007): 412. http://dx.doi.org/10.22621/cfn.v121i4.513.
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Since Trivers and Willard first proposed their hypothesis concerning the adaptive advantages of producing a particular offspring sex in relation to maternal condition in 1973, it has been at the forefront of scientific research concerning sex ratios with most subsequent studies focusing on maternal condition as a key contributor to variations in sex ratios. Another factor that could greatly influence sex ratios, although has been only infrequently examined in mammalian species, is birth date. We investigated how birth date influenced offspring sex ratios in White-tailed Deer (Odocoileus virginianus). Since date of birth can greatly influence an individual’s fitness and reproductive success, we suggest that birth date may be an alternative strategy in determining offspring sex ratios. Since it has been shown that the lifetime reproductive fitness of a mother can be increased by producing a particular sex during a particular time, we hypothesized that more male offspring should be born earlier in the season due to their increased reproductive potential from being born at this time. Offspring born earlier will have a head start in development and therefore have greater potential for increased body size and dominance later in life, traits that greatly influence male reproductive success. In this study, we found that maternal condition did not affect offspring sex ratio in a captive population of White-tailed Deer in Michigan; however, birth date did. We found that more males tended to be born during the second and fourth birthing periods, while more females were born during the first, third and fifth periods. In addition, we found that males born earlier in the season had greater mass the following spring than those born later, a trend that was not as dramatic in females. These results lend moderate support to our hypothesis that in White-tailed Deer offspring sex will tend to vary according to timing of birth and relative reproductive advantages gained by a particular sex being born at that time.
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Teh, Hung Sia, Hiroyuki Kishi, Bernadette Scott, Peter Borgulya, Harald Von Boehmer, and Pawel Kisielow. "Early Deletion and Late Positive Selection of T-Cells Expressing a Male-Specific Receptor in T-Cell Receptor Transgenic Mice." Developmental Immunology 1, no. 1 (1990): 1–10. http://dx.doi.org/10.1155/1990/18208.
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The ontogeny of T cells in T-cell receptor (TCR) transgenic mice, which express a transgenicαβheterodimer, specific for the male (H-Y) antigen in association with H-2Db, was determined. The transgenicαchain was expressed on about 10% of the fetal thymocytes on day 14 of gestation. About 50% of day-15 fetal thymocytes expressed bothαandβtranschains and virtually all fetal thymocytes expressed the transgenicαβheterodimer by day 17. The early expression of the transgenic TCR on CD4-8-thymocytes prevented the development ofγδcells, and led to accelerated growth of thymocytes and an earlier expression of CD4 and CD8 molecules. Up to day 17, no significant differences in T-cell development could be detected between female and male thymuses. By day 18 of gestation, the male transgenic thymus contained more CD4-8-thymocytes than the female transgenic thymus. The preponderance of CD4-8-thymocytes in the male transgenic thymus increased until birth and was a consequence of the deletion of the CD4+8+thymocytes and their CD4-8+precursors. By the time of birth, the male transgenic thymus contained half the number of cells as the female transgenic thymus. The deletion of autospecific precursor cells in the male transgenic mouse began only at day 18 of gestation, despite the fact that the ligand could already be detected by day 16.The preferential accumulation of CD4-8+T cells, which expressed a high density of the transgenic TCR, occurred only after birth and was .obvious in 6-week-old female thymus. These data support the hypothesis that the positive selection of T cells expressing this transgenic heterodimer may involve two steps, i.e., the commitment of CD4+8+thymocytes to the CD4-8+lineage following the interaction of the transgenic TCR with restricting major histocompatibility molecules, followed by a slow conversion of CD4+8+thymocytes into CD4-8+T cells.In normal mice, the precursors of CD+4+8 and single positive thymocytes have the CD4-8-CD3-J11d+(or M1/69+) phenotype. Because of the early expression of the transgenicαβheterodimer, this population was not detected in adult transgenic mice. All CD4-8-M1/ 69+cells expressed the transgenic receptor associated with CD3 and could be readily grown in media containing T-cell lectins and interleukin 2.
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Atreya, Alok, Milan Shrestha, Jenash Acharya, and Sharmila Gurung. "Nepal – exploited by older married man – young unmarried mother accused of infanticide." Medico-Legal Journal 87, no. 3 (June 10, 2019): 127–29. http://dx.doi.org/10.1177/0025817218822009.
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In Nepal, it is considered sinful for a woman to have sexual intercourse before marriage while the male is exonerated. The female will be branded a loose character outcast by family and society. Only a small percentage of women who feel the other way and stand mentally strong or who have family support come out to seek justice. Despite the stringent law, the loopholes in the justice mechanism re-victimise female victims. We report a case where a young unmarried pregnant woman who gave birth alone was charged with infanticide.
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Leclercq, Sébastien, Julien Thézé, Mohamed Amine Chebbi, Isabelle Giraud, Bouziane Moumen, Lise Ernenwein, Pierre Grève, Clément Gilbert, and Richard Cordaux. "Birth of a W sex chromosome by horizontal transfer of Wolbachia bacterial symbiont genome." Proceedings of the National Academy of Sciences 113, no. 52 (December 6, 2016): 15036–41. http://dx.doi.org/10.1073/pnas.1608979113.
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Sex determination is a fundamental developmental pathway governing male and female differentiation, with profound implications for morphology, reproductive strategies, and behavior. In animals, sex differences between males and females are generally determined by genetic factors carried by sex chromosomes. Sex chromosomes are remarkably variable in origin and can differ even between closely related species, indicating that transitions occur frequently and independently in different groups of organisms. The evolutionary causes underlying sex chromosome turnover are poorly understood, however. Here we provide evidence indicating that Wolbachia bacterial endosymbionts triggered the evolution of new sex chromosomes in the common pillbug Armadillidium vulgare. We identified a 3-Mb insert of a feminizing Wolbachia genome that was recently transferred into the pillbug nuclear genome. The Wolbachia insert shows perfect linkage to the female sex, occurs in a male genetic background (i.e., lacking the ancestral W female sex chromosome), and is hemizygous. Our results support the conclusion that the Wolbachia insert is now acting as a female sex-determining region in pillbugs, and that the chromosome carrying the insert is a new W sex chromosome. Thus, bacteria-to-animal horizontal genome transfer represents a remarkable mechanism underpinning the birth of sex chromosomes. We conclude that sex ratio distorters, such as Wolbachia endosymbionts, can be powerful agents of evolutionary transitions in sex determination systems in animals.
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Dorooshi, Gholamali, Shiva Samsam Shariat, Mitra Shirvani, and Shafeajafar Zoofaghari. "Investigating Suicide Rate and Poisoning Severity and Their Relationship With Birth Month." International Journal of Medical Toxicology and Forensic Medicine 9, no. 4 (November 11, 2019): 233–42. http://dx.doi.org/10.32598/ijmtfm.v9i4.26306.
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Background: One of the most frequent causes of death is poisoning worldwide. Investigating the causes of mortality due to poisoning profoundly affects making decisions and improving standards for preventing adverse events. Therefore, to better understand this problem and evaluate the causes, this study aimed to determine the risk of suicide using the SAD PERSONS Scale (SPS) criteria and its relationship with the birth month in poisoned patients.Methods: This cross-sectional descriptive-analytic study was conducted on poisoned patients admitted to Khorshid Hospital in Isfahan City, Iran, in 2018. First, the patients’ age, gender, and birth month were recorded. Then, their suicide risk was assessed by SPS.Results: From 2735 referred patients with poisoning, 1839 (67.2%) attempted suicide, and 896(32.8%) cases were poisoned. The Mean±SD SPS score in patients with suicidal attempts was 4.89±1.94, and in the poisoned patients was equal to 2.74±1.46 (P<0.001). There was no significant relationship between suicide and birth month; however, gender (male), age, depression, previous suicidal attempts, ethanol abuse, rational thinking loss, social support lacking, and being unmarried significantly increased the risk of suicide (P<0.01). In addition, the SPS scores ≥5 with a sensitivity of 43.77%, and specificity of 98.44% had an acceptable diagnostic value in identifying the risk of suicide (P<0.0001).Conclusion: As SPS criteria have an appropriate diagnostic value for suicide prediction, it is recommended that these criteria be assessed among individuals with susceptible suicide characteristics (e.g. males, elders, depression, the lack of social support, etc.), to prevent future suicide attempts and appropriate medical-psychological measures.
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Ohuche, Nancy M., and John M. Littrell. "IGBO Students' Attitudes toward Supporting Aged Parents." International Journal of Aging and Human Development 29, no. 4 (December 1989): 259–67. http://dx.doi.org/10.2190/ggp7-d25b-ll9q-j14l.
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This study was designed to explore attitudes of Nigerian, i.e., Igbo, students toward caring for aged parents. A questionnaire consisting of descriptive information and eighteen statements of attitudes about supporting aged parents was administered to 134 students in a Nigerian teacher training college. Students expressed strong support for caring for aged parents; however, male students were not as keen about supporting aged parents as were females. Students' age correlated negatively with the desire to support aged parents in that older students were less willing to care for their aged parents than were younger students. Factors such as birth order, place of residence in the past five years, religion, and educational levels of the mother and father had no significant relationship with attitudes toward supporting aged parents.
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Ramaswamy, Viraraghavan Vadakkencherry, Sanghamitra Gummadapu, and Nori Suryanarayana. "Nosocomial pneumonia and sepsis caused by a rare organism Cedecea lapagei in an infant and a review of literature." BMJ Case Reports 12, no. 7 (July 2019): e229854. http://dx.doi.org/10.1136/bcr-2019-229854.
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A late preterm male infant of 36 weeks gestation and a birth weight of 2100 g was admitted on day 35 of life with complaints of respiratory distress and lethargy. He was diagnosed as a case of sepsis screen positive culture negative sepsis and was managed with respiratory support and intravenous antibiotics for 10 days. The infant improved clinically and was on spoon feeds by day 14 of admission. On day 14 of admission, he developed new-onset respiratory distress and was diagnosed as a case of nosocomial pneumonia based on chest radiography findings. The blood culture grew a rare organism Cedecea lapagei and a diagnosis of sepsis was also made. The antibiotics were tailored as per the blood culture sensitivity pattern and the infant had clinical improvement in the next 72 hours.
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Waterhouse, Tracey, Shae-Lee Cox, Melanie Snow, Graham Jenkin, and Jill Shaw. "Offspring produced from heterotopic ovarian allografts in male and female recipient mice." Reproduction 127, no. 6 (June 2004): 689–94. http://dx.doi.org/10.1530/rep.1.00081.
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Studies on human ovarian xenografts and mouse allografts indicate that the male hormonal milieu and exogenous gonadotrophin administration stimulate antral follicle growth. However, it is not known whether oocytes produced under these conditions are developmentally competent. The objective of our study was to evaluate the developmental competence of oocytes produced in heterotopic mouse ovarian grafts placed in male and female recipient mice. Gonadotrophins were 7.5 IU pregnant mare serum gonadotrophin (PMSG) alone or 7.5 IU PMSG and 7.5 IU human chorionic gonadotrophin or were not given prior to oocyte collection. The developmental competence of oocytes was assessed by performing in vitro fertilisation and embryo transfer to recipients. When no gonadotrophins were given the cleavage rate was similar for oocytes collected from ovarian grafts in male and female recipients. Gonadotrophin treatment significantly (P < 0.05) increased two-cell formation by oocytes grown in female graft recipients but not in male recipients. Implantation rates, fetal development and the birth of live young were unaffected by the sex of the graft recipient or gonadotrophin treatment. Live offspring were produced from oocytes collected from ovarian grafts in male and female recipients treated with or without gonadotrophins. In conclusion, this work has shown that the hormonal environment of male mice can support the growth of oocytes in ovarian allografts and that these oocytes can produce live offspring.
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Fitzpatrick, Veronica, Michele Mouttapa, Sora Park Tanjasiri, and James Napoli. "Predictors of Women’s Emergency Contraception Use and Men’s Support of Partner’s Use among College Students." Californian Journal of Health Promotion 12, no. 2 (September 1, 2014): 78–89. http://dx.doi.org/10.32398/cjhp.v12i2.2152.
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Background: The unintended pregnancy rate in the United States is high, and emergency contraception (EC) is a birth control method that prevents unintended pregnancies. Despite the fact that many college campuses provide access to EC, undergraduate college students have relatively high rates of unintended pregnancies. Purpose: This study examined whether perceptions and knowledge regarding EC use were associated with women’s intentions to use EC, and men’s intentions to support their partner’s EC use. Methods: This study utilized a convenience sample of 96 female and 118 male southern California community college undergraduate students. Results: Women had stronger intentions to use EC if they thought they could successfully obtain it at a pharmacy, while men reported they were more likely to support a partner’s use if they thought that EC use is morally acceptable. Conclusions: The findings suggest that increasing women’s knowledge about the accessibility of EC may lead to increased use of EC if needed. Men’s moral stance regarding EC use may impact the degree to which they will support their female partners using EC. Further implications are discussed.
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Yonathan, Erico Lemuel, and Hari Darmawan. "Giant Congenital Melanocytic Nevi (GCMN): Sebuah Laporan Kasus Langka." Jurnal Ilmiah Kedokteran Wijaya Kusuma 10, no. 1 (March 25, 2021): 112. http://dx.doi.org/10.30742/jikw.v10i1.1183.
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Giant Congenital Melanocytic Nevi (GCMN) is a nevus which present at birth or arise within the first few weeks of life. Incidence of GCMN is estimated at below 1:20.000 newborns. Lesion of GCMN usually appears with a black or brownish plaque and may have abnormal borders, flat or protruding surface and hypertrichosis. Giant Congenital Melanocytic Nevi (GCMN) is associated with malignant melanoma and neurocutaneous melanocytosis. A male newborn baby is reported to have a giant black hairy plaque, with irregular shape in his head since born. Patient was born naturally, full term, and normal birth weight. The mother has no medication consumption and disease history during pregnancy. In our three years follow up, there are multiple black patches with smaller size in front right and left leg, and the back of the body. The GCMN treatment consists of surgical and non-surgical procedures, psychological support, and lifelong monitoring. In this case, further examination and observation are needed.
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Qurram, Syed M., C. V. S. Lakshmi, Farhana Nazneen, and Mohammed U. Khan. "Urinary ascites in a neonate with posterior urethral valve." International Journal of Contemporary Pediatrics 8, no. 6 (May 25, 2021): 1125. http://dx.doi.org/10.18203/2349-3291.ijcp20212062.
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Urinary ascites in a newborn is an extremely rare condition, most commonly due to posterior urethral valves, due to transmission of high intravesical pressure to calyceal fornices, and subsequent urinary ascites either by calyceal perforation or filtration through walls of urinary tract and their rupture. We describe a newborn male baby, who presented with huge abdominal distension at birth, and diagnosed as urinary ascites on paracentesis. Baby was asphyxiated and required resuscitation at birth, and ventilatory support for 4 days in v/o significant abdominal distension. Micturating cystourethrogram (MCUG) and magnetic resonance imaging (MRI) showed posterior urethral valves. Baby also had a left sided urinoma and grade 4 vesicoureteral reflux (VUR) on MCUG. Post paracentesis and drainage of 400ml of ascetic fluid, and urinary catheterization, baby had significant improvement of deranged renal parameters, and diuresis, and could be weaned from ventilation. In v/o inability to negotiate a urethroscope, a vesicostomy was done for urinary drainage and fulguration of valves planned on follow-up.
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Smith, Marquita R. "Birthing a New World." James Baldwin Review 6, no. 1 (September 29, 2020): 49–63. http://dx.doi.org/10.7227/jbr.6.4.
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This essay analyzes how James Baldwin’s late novel If Beale Street Could Talk represents Black women’s care work in the face of social death as an example of how Black women act as surrogates for Black liberation giving birth to a new world and possibilities of freedom for Black (male) people. Within the politics of Black nationalism, Black women were affective workers playing a vital role in the (re)creation of heteronormative family structures that formed the basis of Black liberation cohered by a belief in the power of patriarchy to make way for communal freedom. This essay demonstrates how Beale Street’s imagining of freedom centers not on what Black women do to support themselves or each other, but on the needs of the community at large, with embodied sacrifice as a presumed condition of such liberation.
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Kalagin, Yuriі. "Crisis of masculinity and health of male servicemen." Grani 23, no. 11 (November 25, 2020): 51–59. http://dx.doi.org/10.15421/1720101.
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The article looks at the problems of preserving social health and individuality in the context of realizing gender stereotypes. The author suggests the results of social research, which was conducted at the laboratory of applied social research of the department of social science and political science of NTU "KhPI" in 2020. Relevance is stipulated by the need to protect human resources in all forms, so that the shosty riches protect sovereignty and territoriality of Ukraine. The personnel of military formations in Ukraine is composed mainly of men, so it is extremely important to support and preserve the health of men. The problem lies in the fact that social media ideology is often panicky, often sponing people to take away the strategy of special behaviors is not a problem for social health. At the middle of the twentieth century, science at large turned out to be a huge respect for the nutrition of healthy’s health and social problems of complicity. In fact, even more than one studio in the United States has earned respect for up to date realization of masculine and ideological ideas for individual health. Віччнінії науковіці долуджудували вкмі Aspects of the flood of masculine ideology, ale better understanding of the context of the social protection of the form of Ukraine in Ukraine on the cob of the 21st table was not carried out. The author has added to the behavior of those stereotypes such as “do not cry”, “say that you are strong but strong”, “say that you’re the mother of the year of birth” to bring back the negative effects. The results of the previous show showed that ideological masculine formук stereotypes, which can be negatively attributed to a healthy person. Namaganiya cholіkіv, so as not to have more than one resource, follow stereotypes of masculine and ideological ideas to negative insights. That, to the author’s thought, is necessary to formulate more critical criticism to sound stereotypes about the “reference person”.
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N., Sharath Chandra, Mohamed Sajjid, Kamalrathnam C. N., and Prakash V. "Study of clincial profile and outcome of Klebsiella sepsis in neonates at a tertiary care centre." International Journal of Contemporary Pediatrics 6, no. 6 (October 21, 2019): 2450. http://dx.doi.org/10.18203/2349-3291.ijcp20194714.
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Background: Objective of the study is to study clinical profile and outcome of Klebsiella sepsis in neonates.Methods: A retrospective observational study from January 2018 to Sep 2018. After getting approval of institute ethics committee, admitted neonates whose blood culture showed Klebsiella growth were enrolled. A detailed history, birth weight, sex , age, APGAR, need for resuscitation at birth, distress at birth, ventilator support, CPAP, central line, blood products, species of Klebsiella and drug sensitivity and outcome-discharge or death were taken. Data were entered into Microsoft excel data sheet and was analyzed using SPSS 23 version software.Results: Out of the total 252 positive blood culture, 110 (43%) grew Klebsiella in blood culture. 92 cases were included in the study. Male to female ratio was 1.24:1. Mean age at admission was 1.22 days. 40 (43.5%) died and 52(56.5%) were discharged. Birth weight was 1.635±802 gm for babies who died and 2211±939 gm among discharged. Mean gestational age were 32.5 weeks in died and 34.8 weeks among discharged. Mortality was 23(57.5%) in males, low birth weight babies 23(59%), thrombocytopenia 28 (78%), invasive mode of ventilation 19(67%). By Univariate analysis, it was found that pregnancy induced hypertension (PIH), premature rupture of membrane (PROM), abnormal APGAR, Birth weight, shock, invasive ventilation, DIC, inotropes, blood products, abnormal total count, thrombocytopenia, umbilical venous catheterization were factors which influenced outcome. Regression analysis identified only thrombocytopenia and umbilical venous catheterization as factors that influenced outcome in Klebsiella sepsis. Klebsiella isolated was uniformly sensitive to Meropenam.Conclusions: No single risk factor was ascertained but thrombocytopenia and umbilical venous catheterization possibly influence the outcome of Klebsiella sepsis. Mortality is high in neonates.
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Masaba, Brian Barasa, and Rose M. Mmusi-Phetoe. "Barriers to and Opportunities for Male Partner Involvement in Antenatal Care in Efforts to Eliminate Mother-to-child Transmission of Human Immunodeficiency Virus in Kenya: Systematic Review." Open Nursing Journal 14, no. 1 (November 20, 2020): 232–39. http://dx.doi.org/10.2174/1874434602014010232.
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Introduction: Men’s involvement in antenatal care (ANC) is intended to encourage husbands to support women’s care and associated interventions, including prevention of mother-to-child transmission from pregnancy to delivery, and throughout the postnatal period. The present study aimed to systematically review the barriers and opportunities for male partner involvement in antenatal care in efforts to eliminate mother-to-child transmission of Human Immunodeficiency virus (HIV) in Kenya. Methods: A systematic search of articles was from the following databases; Scopus, Science Direct, PUBMED, OVID, and Google scholar. The reference list of included studies was manually searched for possible additional eligible articles. The searches were conducted from May 2019 to April 2020. Qualitative analysis was done and data were presented in thematic domains. Results: The search generated 2208 articles, of which only 19 met the inclusion criteria. The major findings were discussed under two thematic domains: 1) Barriers: Knowledge, Social-cultural/economic factors, Institutional factors, and Age. 2) Opportunities: Skilled Birth Attendant, Human Immunodeficiency virus-free infant and Human Immunodeficiency virus testing. Conclusion: The review notes that the main barriers to male partner involvement in antenatal care in efforts to eliminate mother-to-child transmission of Human Immunodeficiency virus in Kenya include; socio-cultural factors, the low maternal-child health education by the male partner, and institutional factors. It further provides insight on the opportunities associated with male partner involvement in antenatal care/prevention of mother-to-child transmission, which includes; having Human Immunodeficiency virus-free infants and increased, skilled birth deliveries. The review strongly calls out for sustainable initiatives to incorporate males into the antenatal care/prevention of mother to child transmission programs.
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Pontesilli, M., M. H. Hof, A. C. J. Ravelli, A. J. van Altena, A. T. Soufan, B. W. Mol, E. H. Kostelijk, et al. "Effect of parental and ART treatment characteristics on perinatal outcomes." Human Reproduction 36, no. 6 (April 16, 2021): 1640–65. http://dx.doi.org/10.1093/humrep/deab008.
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Abstract STUDY QUESTION Do parental characteristics and treatment with ART affect perinatal outcomes in singleton pregnancies? SUMMARY ANSWER Both parental and ART treatment characteristics affect perinatal outcomes in singleton pregnancies. WHAT IS KNOWN ALREADY Previous studies have shown that singleton pregnancies resulting from ART are at risk of preterm birth. ART children are lighter at birth after correction for duration of gestation and at increased risk of congenital abnormalities compared to naturally conceived children. This association is confounded by parental characteristics that are also known to affect perinatal outcomes. It is unclear to which extent parental and ART treatment characteristics independently affect perinatal outcomes. STUDY DESIGN, SIZE, DURATION All IVF clinics in the Netherlands (n = 13) were requested to provide data on all ART treatment cycles (IVF, ICSI and frozen-thawed embryo transfers (FET)), performed between 1 January 2000, and 1 January 2011, which resulted in a pregnancy. Using probabilistic data-linkage, these data (n = 36 683) were linked to the Dutch Perinatal Registry (Perined), which includes all children born in the Netherlands in the same time period (n = 2 548 977). PARTICIPANTS/MATERIALS, SETTING, METHODS Analyses were limited to singleton pregnancies that resulted from IVF, ICSI or FET cycles. Multivariable models for linear and logistic regression were fitted including parental characteristics as well as ART treatment characteristics. Analyses were performed separately for fresh cycles and for fresh and FET cycles combined. We assessed the impact on the following perinatal outcomes: birth weight, preterm birth below 37 or 32 weeks of gestation, congenital malformations and perinatal mortality. MAIN RESULTS AND THE ROLE OF CHANCE The perinatal outcomes of 31 184 out of the 36 683 ART treatment cycles leading to a pregnancy were retrieved through linkage with the Perined (85% linkage). Of those, 23 671 concerned singleton pregnancies resulting from IVF, ICSI or FET. Birth weight was independently associated with both parental and ART treatment characteristics. Characteristics associated with lower birth weight included maternal hypertensive disease, non-Dutch maternal ethnicity, nulliparity, increasing duration of subfertility, hCG for luteal phase support (compared to progesterone), shorter embryo culture duration, increasing number of oocytes retrieved and fresh embryo transfer. The parental characteristic with the greatest effect size on birth weight was maternal diabetes (adjusted difference 283 g, 95% CI 228–338). FET was the ART treatment characteristic with the greatest effect size on birth weight (adjusted difference 100 g, 95% CI 84–117) compared to fresh embryo transfer. Preterm birth was more common among mothers of South-Asian ethnicity. Preterm birth was less common among multiparous women and women with ‘male factor’ as treatment indication (compared to ‘tubal factor’). LIMITATIONS, REASONS FOR CAUTION Due to the retrospective nature of our study, we cannot prove causality. Further limitations of our study were the inability to adjust for mothers giving birth more than once in our dataset, missing values for several variables and limited information on parental lifestyle and general health. WIDER IMPLICATIONS OF THE FINDINGS Multiple parental and ART treatment characteristics affect perinatal outcomes, with birth weight being influenced by the widest range of factors. This highlights the importance of assessing both parental and ART treatment characteristics in studies that focus on the health of ART-offspring, with the purpose of modifying these factors where possible. Our results further support the hypothesis that the embryo is sensitive to its early environment. STUDY FUNDING/COMPETING INTEREST(S) This study was funded by Foreest Medical School, Alkmaar, the Netherlands (grants: FIO 1307 and FIO 1505). B.W.M. reports grants from NHMRC and consultancy for ObsEva, Merck KGaA, iGenomics and Guerbet. F.B. reports research support grants from Merck Serono and personal fees from Merck Serono. A.C. reports travel support from Ferring BV. and Theramex BV. and personal fees from UpToDate (Hyperthecosis), all outside the remit of the current work. The remaining authors report no conflict of interests. TRIAL REGISTRATION NUMBER N/A.
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Johansson, Malin, and Finn Rasmussen. "Birthweight and Body Mass Index in Young Adulthood: The Swedish Young Male Twins Study." Twin Research 4, no. 5 (October 1, 2001): 400–405. http://dx.doi.org/10.1375/twin.4.5.400.
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AbstractMany studies have found an inverse association between fetal growth and cardiovascular disease related to the metabolic syndrome in adulthood. Nevertheless, the relative importance of genetics and the intrauterine environment remain unclear. The objective of the study was to test the fetal origins hypothesis and the fetal insulin resistance hypothesis by studying the impact of fetal growth on Body Mass Index (BMI) in young adulthood. In a nationwide cohort study, the Swedish Medical Birth Register for the years 1973–1979 was linked with the Military Service Conscription Register for 1990–1999. In 1998 a questionnaire was mailed to all male twins, included in the two registers, who were alive and still resident in Sweden. The study covers the 923 male twin pairs for which full data were available. Mixed linear models were used to estimate within-pair and between-pair differences in birthweight and their relations to BMI. A weak positive association was found among the monozygotic twins for the withinpair difference in birthweight and BMI. No significant association was found among the monozygotic for the between-pair difference in birthweight and BMI. No significant associations were found for dizygotic twins. These findings do not seem to support either the fetal programming hypothesis or the fetal insulin resistance hypothesis.
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JEYASEELAN, L., and M. LAKSHMAN. "RISK FACTORS FOR MALNUTRITION IN SOUTH INDIAN CHILDREN." Journal of Biosocial Science 29, no. 1 (January 1997): 93–100. http://dx.doi.org/10.1017/s002193209700093x.
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Protein energy malnutrition is a major health problem in India and it affects the growth and development of young children. This study investigated the impact of hygiene, housing and sociodemographic variables on acute malnutrition in children aged 5–7, living in urban and rural areas. Ordinal logistic regression analysis showed that the overall prevalence of severe malnutrition was 8·2%. Older age, male sex, mother's poor education, lower family income, higher birth order of the child, use of dung or fire wood as fuel and defecation within the premises were significantly associated with malnutrition. Appropriate intervention programmes should be formulated to educate and support these families.
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Jan, Sheng-Ling, Ming-Chih Lin, and Sheng-Ching Chan. "Mid-term follow-up study of neonatal isolated aberrant right subclavian artery." Cardiology in the Young 28, no. 8 (June 28, 2018): 1024–30. http://dx.doi.org/10.1017/s1047951118000872.
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AbstractBackgroundAberrant right subclavian artery is the most common congenital aortic arch anomaly. There are a few reports concerning the clinical manifestations and follow-up of this CHD detected by echocardiographic screening.MethodsA total of 1737 full-term neonates, with a male-to-female ratio of 900:837, received echocardiographic screening. Neonates with or without isolated aberrant right subclavian artery were studied during infancy.ResultsAmong the 1737 cases, a total of 15 (0.86%) female-predominant neonates, with a male-to-female ratio of 6:9, had isolated aberrant right subclavian artery. They were compared with 20 age- and gender-matched normal neonates. There were no significant differences in maternal age, gestational age, or para gravity between the two groups, except for birth size (birth length- and weight-for-age percentiles, p = 0.006 and 0.045, respectively), which was smaller in the aberrant right subclavian artery group. Although there were no significant differences in developmental history, gastrointestinal, or respiratory symptoms, neonates with aberrant right subclavian artery had a higher incidence of mild developmental delay and feeding difficulty than normal infants (21 versus 0%, p = 0.061; 36 versus 20%, p = 0.264, respectively). The growth rates of body length and weight during infancy were not significantly different between the two groups.ConclusionsEchocardiography can be applied as a first-line investigation in the diagnostic work-up for aberrant right subclavian artery. Neonates with aberrant right subclavian artery had a smaller size at birth, although growth rates were not significantly different from those of normal infants. This study does not support an active surgical policy for asymptomatic infants with isolated aberrant right subclavian artery. A larger study and longer follow-up of affected infants is recommended.
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Vailaya, C. G. Raghavendra, and C. R. Shubha Vailaya. "Study of number of children preferred and knowledge, attitude, practice regarding birth spacing and contraception among primigravida in urban setting." International Journal of Contemporary Pediatrics 7, no. 4 (March 21, 2020): 757. http://dx.doi.org/10.18203/2349-3291.ijcp20201003.
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Background: Overpopulation is a major problem in 21st century India. 2012 census shows birth rate of 20.97/1000 people and death rate of 7.48/1000 people. Fertility rate in 2019 was 2.28 children per women. Many states implemented 2 child norms. Purpose of study is to understand the number of children preferred.Methods: A Cross sectional study was done amongst 200 primigravida women who attended antenatal clinic at SMC, Shimoga. A predesigned and pretested standard Questionnaire was used to know the number of children preferred, KAP about birth spacing, contraceptive use and unsafe abortions using objective questions.Results: Most women preferred 2 child norms across most subclasses. Most Muslims (85.7%) preferred ≥3 children. Though 100% were aware of family planning, only 46% chose to space their next pregnancy. 56.5% were in support of 2-child norm. Family pressure plays crucial role in 83.5% cases and 65.5% still opted sterilization as the first choice for contraception.Conclusions: India with high population density is staring at demographic disaster due to limited life resources. Right attitude towards birth spacing, contraceptive use, avoidance unwanted pregnancies and unsafe abortions is needed. Better female literacy, societal awareness and good medical facility at last mile is crucial. Male partner’s involvement in every step is vital.
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Mohammed, Shamsudeen, Ibrahim Yakubu, and Issahaku Awal. "Sociodemographic Factors Associated with Women’s Perspectives on Male Involvement in Antenatal Care, Labour, and Childbirth." Journal of Pregnancy 2020 (January 25, 2020): 1–9. http://dx.doi.org/10.1155/2020/6421617.
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Background. Evidence suggests that in patriarchal societies such as Ghana, access to and survival of maternal and child healthcare services require the active involvement of men. However, interventions to promote men’s involvement in maternal and child health care are less likely to succeed if the views and concerns of women are not considered. This study provides an understanding of women’s perspective on men’s involvement in antenatal care, labour, and childbirth in the Northern Region of Ghana. Methods. Data for this cross‐sectional study were collected from 300 pregnant women using a structured questionnaire. Logistic regression models were then used to determine the socio‐demographic factors associated with women’s perspectives on men’s involvement in antenatal care, labour, and childbirth. Results. The mean age of the participants was 28 (SD = 5.21) years. More than four-fifths of the women in this study express the desire for male partner involment in natenatal care (ANC) services (n = 258, 86%) and as companions during labour and child birth (n = 254, 84.7%). We found that married women were 9.8 times more likely (95%CI 1.59, 60.81) to encourage male involvement in ANC compared to women who were unmarried. The probability of encouraging male involvement in ANC decreased with increased level of education among the women while support for male companionship during childbirth increased significantly with an increased level of education. After accounting for the effect of other significant covariates, there was good evidence to suggest that married women (p = 0.002), women with only primary/Junior High School education (p = 0.048) and those with two (p = 0.010), three (p = 0.008), or ≥4 (p = 0.044) previous pregnancies had a desire for male partner involvement in ANC while women who attained secondary (p = 0.004) or tertiary (p = 0.001) level education expressed the desire for male companionship in labour and childbirth in the adjusted model. Conclusion. Male involvement in antenatal care, labour, and childbirth received overwhelming support from the women in this study.