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Relevant bibliographies by topics / Male contraception - Genetics

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Academic literature on the topic 'Male contraception - Genetics'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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Journal articles on the topic "Male contraception - Genetics"

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Thirumalai, Arthi, and Stephanie T. Page. "Male Hormonal Contraception." Annual Review of Medicine 71, no. 1 (January 27, 2020): 17–31. http://dx.doi.org/10.1146/annurev-med-042418-010947.

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The economic and public health burdens of unplanned pregnancies are evident globally. Since the introduction of the condom >300 years ago, assumptions about male willingness to participate in contraception, as well as concerns about failure rates and side effects, have stagnated the development of additional reversible male contraceptives. However, changing attitudes and recent research advances have generated renewed interest in developing reversible male contraceptives. To achieve effective and reversible suppression of spermatogenesis, male hormonal contraception relies on suppression of testicular testosterone and sperm production using an androgen-progestin combination. While these may be associated with side effects—changes in libido, weight, hematocrit, and cholesterol—recently, novel androgens and progestins have shown promise for a “male pill” with reduced side effects. Here we summarize landmark studies in male contraceptive development, showcase the most recent advances, and look into the future of this field, which has the potential to greatly impact global public health.

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Veräjänkorva, Esko, Mika Martikainen, Antti Saraste, Jari Sundström, and Pasi Pöllänen. "Sperm antibodies in rat models of male hormonal contraception and vasectomy." Reproduction, Fertility and Development 11, no. 1 (1999): 49. http://dx.doi.org/10.1071/rd98082.

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The presence of sperm antibodies correlates with nearly every pathological condition of the male reproductive tract. In the seasonal breeder, mink, a decrease in gonadotrophin secretion and testicular regression also induces sperm antibodies. Because the Sertoli cells and the principal cells of the epididymis (i.e. the cells mainly responsible for protection of germ cells from autoimmune destruction) are dependent on androgens, and because the androgen concentration decreases in both the testis and epididymis during male hormonal contraception, the presence of IgG class sperm antibodies in serum was studied in rats during the suppression and recovery phases of testosterone contraception and after vasectomy. Five-centimetre long testosterone implants were placed under the dorsal skin of rats under pentobarbitone anaesthesia. The control rats received empty implants. All implants were left in the rats for 27 or 53 days. The total number of testicular antigens detected by sera from the vasectomized rats increased significantly until 66 days post-operation, and then decreased to the levels of intact rats. The number of testicular antigens detected by sera from rats receiving contraceptive doses of testosterone did not increase before the testosterone capsules were removed, but at 40 days post removal of the silastic capsules, the number of antigens detected by the sera was significantly higher than in intact rats and at 77 days post removal of the silastic capsules, the number of antigens detected by the sera was significantly higher than at 27 days after starting testosterone administration. No significant changes in the number of antigens detected by the sera could be observed after the implanting of empty capsules or after their removal. Vasectomy mostly induced antibodies against testicular antigens in the molecular ratio ranges of 70–82, 25–33 and 21–24.5 kD. Antibodies against antigens in these molecular ratio ranges were not significantly induced during or after treatment with contraceptive doses of testosterone. Cell nuclei with apoptotic morphology could be observed in the seminiferous tubules of the vasectomized rats, but DNA in situ 3′-end labelling of testes could not confirm any differences between the testes of vasectomized and sham-operated rats or between testosterone-treated and empty implant-treated rats. CD3 + T cells could not be observed in the testes of any of the treatment groups. These results suggest that the immunological conditions remain stable in the testes after vasectomy and during testosterone treatment, but that the animals are more prone to develop autoantibodies after vasectomy and during recovery from treatment with exogenous testosterone.

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Viejo-Borbolla, Abel. "Temperature control of spermatogenesis and prospect of male contraception." Frontiers in Bioscience S2, no. 2 (2010): 730–55. http://dx.doi.org/10.2741/s97.

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Zdrojewicz, Zygmunt, Radosław Konieczny, Paulina Papier, and Filip Szten. "Brdt Bromodomains Inhibitors and Other Modern Means of Male Contraception." Advances in Clinical and Experimental Medicine 24, no. 4 (2015): 705–14. http://dx.doi.org/10.17219/acem/33827.

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Naz, Rajesh, K. "Gene knockouts that affect male fertility: novel targets for contraception." Frontiers in Bioscience Volume, no. 14 (2009): 3994. http://dx.doi.org/10.2741/3507.

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Multigner, Luc, and Alejandro Oliva. "Environment as a Risk Factor for Male Infertility." Scientific World JOURNAL 1 (2001): 576–78. http://dx.doi.org/10.1100/tsw.2001.296.

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Infertility affects 15% of couples in Western countries. Infertility is defined as the inability to conceive after 1 year of attempts without contraception, but it is not synonymous with sterility. Between 30 and 50% of infertile couples are infertile due to male reasons, mainly due to sperm production disorders. Although some risk factors, most of which are infectious, have been identified, there is still much uncertainty about the origins of male infertility.

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Crawford, Jeremy Chase, Marylène Boulet, and Christine M. Drea. "Smelling wrong: hormonal contraception in lemurs alters critical female odour cues." Proceedings of the Royal Society B: Biological Sciences 278, no. 1702 (July 28, 2010): 122–30. http://dx.doi.org/10.1098/rspb.2010.1203.

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Animals, including humans, use olfaction to assess potential social and sexual partners. Although hormones modulate olfactory cues, we know little about whether contraception affects semiochemical signals and, ultimately, mate choice. We examined the effects of a common contraceptive, medroxyprogesterone acetate (MPA), on the olfactory cues of female ring-tailed lemurs ( Lemur catta ), and the behavioural response these cues generated in male conspecifics. The genital odorants of contracepted females were dramatically altered, falling well outside the range of normal female variation: MPA decreased the richness and modified the relative abundances of volatile chemicals expressed in labial secretions. Comparisons between treatment groups revealed several indicator compounds that could reliably signal female reproductive status to conspecifics. MPA also changed a female's individual chemical ‘signature’, while minimizing her chemical distinctiveness relative to other contracepted females. Most remarkably, MPA degraded the chemical patterns that encode honest information about genetic constitution, including individual diversity (heterozygosity) and pairwise relatedness to conspecifics. Lastly, males preferentially investigated the odorants of intact over contracepted females, clearly distinguishing those with immediate reproductive potential. By altering the olfactory cues that signal fertility, individuality, genetic quality and relatedness, contraceptives may disrupt intraspecific interactions in primates, including those relevant to kin recognition and mate choice.

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FARDILHA, MARGARIDA, WENJUAN WU, ROSÁLIA SÁ, SARA FIDALGO, CRISTINA SOUSA, CATARINA MOTA, ODETE A. B. CRUZ E SILVA, and EDGAR F. CRUZ E SILVA. "Alternatively Spliced Protein Variants as Potential Therapeutic Targets for Male Infertility and Contraception." Annals of the New York Academy of Sciences 1030, no. 1 (December 2004): 468–78. http://dx.doi.org/10.1196/annals.1329.059.

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Page, S. T., J. K. Amory, B. D. Anawalt, A. M. Matsumoto, A. T. Brockenbrough, M. S. Irwig, and W. J. Bremner. "94 IS THERE A ROLE FOR GONADOTROPIN-RELEASING HORMONE ANTAGONISTS IN MALE HORMONAL CONTRACEPTION?" Journal of Investigative Medicine 54, no. 1 (January 1, 2006): S95.6—S96. http://dx.doi.org/10.2310/6650.2005.x0004.93.

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Mulatu, Teshale, Yitagesu Sintayehu, Yadeta Dessie, and Merga Deressa. "Modern Family Planning Utilization and Its Associated Factors among Currently Married Women in Rural Eastern Ethiopia: A Community-Based Study." BioMed Research International 2020 (December 29, 2020): 1–9. http://dx.doi.org/10.1155/2020/6096280.

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Background. The use of modern family planning methods among women of reproductive age (15-49 years) is of public health importance in Ethiopia. Nationally, modern family planning method use remains as low as 35%. Understanding factors associated with the use of modern family planning methods may help to improve maternal and child health. Hence, this study is aimed at assessing modern family planning method use and its determinants among women of reproductive age in the rural districts of Eastern Hararghe zone, Eastern Ethiopia. Methodology. A community-based, cross-sectional survey was conducted among 577 randomly selected, currently married, reproductive-aged women in selected rural districts of Eastern Hararghe, Eastern Ethiopia. Data were collected using a pretested, interviewer-administered questionnaire about women’s sociodemographic information, knowledge about contraception, reproductive history, contraceptive use and fertility desire, couple’s communication, and decision-making on family planning. Binary and multivariable logistic regression was used to analyze the association between the dependent and independent variables. Result. A total of 555 study participants participated, yielding a 96.2% response rate. The overall modern family planning utilization among the study participants was 18.4%. Knowledge of modern family planning methods ( AOR = 16.958 , CI: 4.768, 60.316), husband approval ( AOR = 3.590 , CI: 2.170, 5.936), couple’s discussion ( AOR = 2.852 , CI: 1.759, 4.623), male involvement in decisions about family planning ( AOR = 2.340 , CI: 1.531, 3.576), desire for additional child ( AOR = 2.295 , CI: 1.528, 3.447), and previous use of contraception ( AOR = 0.018 , CI: 0.005, 0.063) were significantly associated with modern contraceptive utilization. Conclusion. Even though knowledge of modern family planning methods was very high, the overall modern family planning method use in the study area was low. The government should focus on increasing modern family planning method availability. It must also ensure family planning method security and create awareness on modern family planning methods through community-based education and proper counselling to empower women to make an appropriate choice.

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Dissertations / Theses on the topic "Male contraception - Genetics"

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呂穎怡 and Wing-yee Lui. "Regulation of junction dynamics in the testis: a new approach for male contraception." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2002. http://hub.hku.hk/bib/B31243447.

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Lui, Wing-yee. "Regulation of junction dynamics in the testis : a new approach for male contraception /." Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B25155222.

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Books on the topic "Male contraception - Genetics"

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Edenborough, Frank P. Fertility, contraception, and pregnancy. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198702948.003.0012.

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This chapter describes the physiological effect of CFTR dysfunction on the development of the reproductive system. Young people with CF and their parents are poorly educated regarding sexual function and becoming parents themselves. They often wish to learn this from their CF teams. Male and female potency, reproductive genetics, and the need for genetic and general counselling before embarking on pregnancy are covered. Contraception, emphasizing the need to avoid unwanted pregnancy and sexually transmitted diseases, and assisted reproductive techniques are described. We discuss the evolving medical and obstetric management of pregnancy, including the likely need for optimizing drug treatment or escalating to more intensive treatment for intercurrent infection. Optimal delivery in the context of maternal health, fetal risks, and longer term maternal outcomes are discussed. Pregnancy post transplantation and termination of unwanted pregnancy or where the mother is too poorly to continue conclude the chapter.

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Bartlik, Barbara, Amandeep Kaur, Chelsea Schoen, and Julie Kolzet. Birth Control Pills and Hormonal Contraception (DRAFT). Edited by Madeleine M. Castellanos. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190225889.003.0009.

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This chapter reviews the existing literature on the use of hormonal contraception (HC) and sexual functioning. In the cases where HC has been shown to lead to a decrease in sexual functioning, the chapter presents several hypotheses for the mechanisms that could be responsible for those changes, such as micronutrient depletion and elevations in sex hormone binding globulin with consequent reductions in free testosterone. Throughout this chapter, the authors make a case for clinicians to take care to inform patients of the potential sexual side effects of hormonal contraceptives, bearing in mind that it may be advisable for women who use them to supplement with certain vitamins and minerals. This may be an especially important consideration for women with genetic polymorphisms in methylation. The chapter concludes with a clinical case study.

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Book chapters on the topic "Male contraception - Genetics"

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"Male Contraceptive." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics, 1146. Dordrecht: Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_9789.

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Chin, Jennifer, and Marguerite Lisa Bartholomew. "Aortic Aneurysm in Pregnancy." In Aortic Aneurysm - Clinical Findings, Diagnostic and Treatment [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.96238.

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Aortic aneurysms in pregnancy are rare but often fatal due to the natural physiologic changes of pregnancy and comorbidities specific to pregnancy, which increase the risk for aortic dissection and rupture. These physiologic changes are most pronounced in the third trimester and during the peripartum period, when approximately one third of dissections occur. In patients with known aortic aneurysms or conditions that make them prone to aortic aneurysms, preconception counseling can make pregnancy safer and more manageable. Aortic aneurysms diagnosed during pregnancy are usually due to underlying connective tissue diseases or aortopathies that have not been previously diagnosed. These women require multidisciplinary care including but not limited to obstetrics and gynecology, maternal fetal medicine, neonatology, cardiology, cardiothoracic surgery, cardiothoracic anesthesia, and genetics. Decisions include screening for dissection, when to proceed with surgical management, the best mode and timing for delivery, postpartum care, and contraception.

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