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Dissertations / Theses on the topic 'Malignant germ cell tumor'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Murray, Matthew Jonathan. "The role of microRNAs in paediatric malignant germ cell tumours." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608213.

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2

Ferraresso, Marta. "Downregulation of miRNA expression in malignant germ cell tumours : mechanism and functional significance." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/290258.

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Germ cell tumours (GCTs) are clinically and pathologically heterogeneous neoplasms that arise at gonadal (testicular/ovarian) and extra-gonadal sites. The chemotherapy burden for patients with malignant germ cell tumours (mGCTs) that require treatment results in substantial longterm side-effects, and, furthermore, poor-risk patients have < 50% survival. Consequently, identifying common molecular changes and novel therapeutic targets in mGCTs is of major clinical importance. MicroRNAs are short, non-protein coding RNAs that regulate gene expression. We previously showed that miR-99a-5p/-100-5p

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3

Shah, Rachana M. D. "Dysgerminoma in Children, Adolescent and Young Adults: A Report from the Malignant Germ Cell Tumor International Collaborative (MaGIC)." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1505123966588768.

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4

Tsatalpas, Panagiotis, Bettina Beuthien-Baumann, Joachim Kropp, et al. "Diagnostic Value of 18F-FDG Positron Emission Tomography for Detection and Treatment Control of Malignant Germ Cell Tumors." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-133857.

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Introduction: The role of positron emission tomography (PET) with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) is currently under evaluation in urologic oncology. The aim of the present study was to investigate the use of [18F]FDG positron emission tomography ([18F]FDG-PET) in the detection and treatment control of malignant germ cell tumors compared to computed tomography (CT). Materials and Methods: Thirty-two PET studies and CT scans were carried out in 23 patients with histologically proven germ cell tumors (10 seminomas, 12 non-seminomatous germ cell tumors (NSGCT), 1 unclassified serologic

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5

Tsatalpas, Panagiotis, Bettina Beuthien-Baumann, Joachim Kropp, et al. "Diagnostic Value of 18F-FDG Positron Emission Tomography for Detection and Treatment Control of Malignant Germ Cell Tumors." Karger, 2002. https://tud.qucosa.de/id/qucosa%3A27542.

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Introduction: The role of positron emission tomography (PET) with 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) is currently under evaluation in urologic oncology. The aim of the present study was to investigate the use of [18F]FDG positron emission tomography ([18F]FDG-PET) in the detection and treatment control of malignant germ cell tumors compared to computed tomography (CT). Materials and Methods: Thirty-two PET studies and CT scans were carried out in 23 patients with histologically proven germ cell tumors (10 seminomas, 12 non-seminomatous germ cell tumors (NSGCT), 1 unclassified serologi

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6

Sidhu, Harmanjit Singh. "Modulation of malignancy/metastasis of germ cell tumors : differentiation by nerve growth factor." Honors in the Major Thesis, University of Central Florida, 1996. http://digital.library.ucf.edu/cdm/ref/collection/ETH/id/157.

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This item is only available in print in the UCF Libraries. If this is your Honors Thesis, you can help us make it available online for use by researchers around the world by following the instructions on the distribution consent form at http://library.ucf.edu/Systems/DigitalInitiatives/DigitalCollections/InternetDistributionConsentAgreementForm.pdf You may also contact the project coordinator, Kerri Bottorff, at kerri.bottorff@ucf.edu for more information.<br>Bachelors<br>Arts and Sciences<br>Biology

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7

Anderson, Philip D. "Genetic control of testicular germ cell tumor susceptibility in mice." Case Western Reserve University School of Graduate Studies / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1247182449.

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8

Palmer, Roger David. "Analysis of the genome and transcriptome in primary paediatric malignant germ cell tumours." Thesis, University of Cambridge, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611210.

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9

Hunt, G. "The metastatic inefficiency of malignant glioma." Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.377441.

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10

Liu, Zhiwen. "Matrix metalloproteases and cell motility in malignant mesothelioma /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7140-061-3/.

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11

Makii, Rebecca. "Characterization of Wwox Expression and Function in Canine Mast Cell Tumors and Malignant Mast Cell Lines." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1587715457656348.

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12

Hakelius, Malin. "Interactions between Malignant Keratinocytes and Fibroblasts : Studies in Head and Neck Squamous Cell Carcinoma." Doctoral thesis, Uppsala universitet, Plastikkirurgi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-221109.

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Carcinoma growth requires a supportive tumor stroma. The concept of reciprocal interactions between tumor and stromal cells has become widely acknowledged and the connective tissue activation seen in the malignant process has been likened to that of a healing wound. Little is, however, known about the specific characteristics of these interactions, distinguishing them from the interplay occurring between epithelial and stromal cells in wound healing. In order to study differences in the humoral effects of malignant and benign epithelial cells on fibroblasts, we used an in vitro coculture model

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13

Tecleab, Awet G. "Regulation of the Tumor Suppresser p53 and Survivin by Ras and Ral GTPases:Implications for Malignant Transformation." Scholar Commons, 2013. http://scholarcommons.usf.edu/etd/4591.

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Abstract Although the critical role of the small GTPases Ras and Ral in oncogenesis has been well documented, much remains to be investigated about the molecular mechanism by which these GTPases regulate malignant transformation. The work under this thesis made two major contributions to this field. The first is the discovery that K-Ras, RalA and/or RalB are required for the maintenance of the high levels of the anti-apoptotic protein survivin in some human cancer cells, and the second is the demonstration that down regulation of K-Ras, RalA and/or RalB, but not Raf-1 or Akt1/2, stabilizes the

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14

Stangl, Stefan [Verfasser], Johannes [Akademischer Betreuer] Buchner, and Gabriele [Akademischer Betreuer] Multhoff. "Tumor cell-selective membrane Hsp70 targeting of malignant lesions / Stefan Stangl. Betreuer: Johannes Buchner. Gutachter: Gabriele Multhoff ; Johannes Buchner." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1079974644/34.

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15

Paul, Milan [Verfasser], and Tobias [Akademischer Betreuer] Feuchtinger. "Induction of T-cell responses against mutation-specific peptides from malignant pediatric brain tumor samples / Milan Paul ; Betreuer: Tobias Feuchtinger." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2020. http://d-nb.info/1223369846/34.

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Nastaly, Paulina [Verfasser], and Klaus [Akademischer Betreuer] Pantel. "Detection and characterization of circulating tumor cells in patients with testicular germ cell tumors and prostate cancer / Paulina Nastaly. Betreuer: Klaus Pantel." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2014. http://d-nb.info/1059237822/34.

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17

Kurata, Yasuhisa. "Diagnostic performance of MR imaging findings and quantitative values in the differentiation of seromucinous borderline tumour from endometriosis-related malignant ovarian tumour." Kyoto University, 2018. http://hdl.handle.net/2433/232129.

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18

MATSUYAMA, MUTSUSHI, R. KAZUHIKO UTSUMI, AKIRA MASUDA, MASAHIDE TAKAHASHI, WORAWIDH WAJJWALKUI, and YOSHIHISA SAKAI. "Expression of Proto-Oncogenes and Tumor Suppressor Genes in in vitro Cell Lines Derived from a Thymus, Thymoma, and Malignant Thymoma of Rats." Nagoya University School of Medicine, 1993. http://hdl.handle.net/2237/17542.

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19

Hamada, Shota. "Antiemetic efficacy and safety of a combination of palonosetron, aprepitant, and dexamethasone in patients with testicular germ cell tumor receiving 5-day cisplatin-based combination chemotherapy." 京都大学 (Kyoto University), 2014. http://hdl.handle.net/2433/192148.

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Published in Supportive Care in Cancer 2014;22(8):2161-6. DOI:10.1007/s00520-014-2182-7<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(社会健康医学)<br>甲第18548号<br>社医博第59号<br>新制||社医||8(附属図書館)<br>31448<br>京都大学大学院医学研究科社会健康医学系専攻<br>(主査)教授武藤学, 教授佐藤俊哉, 教授千葉勉<br>学位規則第4条第1項該当

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20

Leruste, Amaury. "Immune context of malignant rhabdoid tumors : description and identification of new therapeutic targets." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS050.

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Les tumeurs rhabdoïdes (TR) constituent un rare cancer indifférencié du jeune enfant et du nourrisson, avec un âge médian au diagnostic de 20 mois. Ces tumeurs sont caractérisées par une inactivation biallélique du gène suppresseur de tumeur SMARCB1, un des membres du complexe SWI/SNF, acteur majeur du remodelage de la chromatine, sans autre altération génomique récurrente. Le pronostic des TR est péjoratif, le taux de survie globale atteignant 30% dans la plupart des séries, malgré des approches thérapeutiques conventionnelles particulièrement agressives. Les approches d’immunothérapies ont o

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21

Waker, Christopher A. "Metabolic Characterization of MPNST Cell Lines." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1433182427.

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22

Mola, Silvia. "Tumor Associated Macrophages (TAMs) a pivotal orchestrator in cancer-related inflammation and a new important target in cancer-therapy." Doctoral thesis, Università del Piemonte Orientale, 2021. https://hdl.handle.net/11579/127797.

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Macrophages are pivotal orchestrators of tumor-promoting inflammation and promising targets for new anti-cancer therapies. To identify new molecular players underlying their pro-tumoral activities, we analyzed the phosphoproteoma of tumor associated macrophages (TAMs) isolated from murine fibrosarcoma. We identified the protein TRIM28, a pleiotropic molecule that is known to be involved in the dynamic organization of chromatin, and we characterized the signaling pathway driving its phosphorylation in response to inflammatory signals and its impact on LPS-induced gene expression. We explored in

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23

Rick, Oliver. "Therapieoptimierungsverfahren bei Patienten mit rezidivierten oder progredienten Keimzelltumoren." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/13921.

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Patienten mit metastasierten Keimzelltumoren, die einen Progress oder ein Rezidiv ihrer Erkrankung nach einer cisplatinhaltigen Vortherapie erleiden, haben eine schlechte Prognose. Unter Verwendung einer erneuten konventionellen Chemotherapie können maximal 15-30% dieser Patienten geheilt werden, so dass die Mehrzahl der Patienten an ihrer Erkrankung verstirbt. Aus diesem Grund ist die Optimierung der therapeutischen Möglichkeiten ein wesentliches Ziel. Unsere Daten zeigen, dass die Hochdosischemotherapie (HDCT) eine wesentliche therapeutische Verbesserung darstellt und mittels dieser Therapie

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24

Mahller, Yonatan Y. "Development of Oncolytic HSV-1 as an Anticancer Therapeutic for Extracranial Neural Tumors and Cancer Stem Cells." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1190588795.

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25

Beyer, Jörg. "Hochdosischemotherapie bei Patienten mit rezidivierten und refraktären Keimzelltumoren Etablierung und Optimierung eines neuen Therapieverfahrens." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2000. http://dx.doi.org/10.18452/13707.

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Rezidivierte und refraktäre Hodentumoren waren bis zu Beginn der 80er Jahre nur selten kurativ behandelbar. Mit Einführung der Hochdosischemotherapie in Verbindung mit autologer Stammzellreinfusion, konnte eine kurative Behandlungsoption auch in dieser prognostisch ungünstigen Situation in der Klinik etabliert werden. Die vorliegende Arbeit beschreibt die Ergebnisse der ersten Phase I/II Studie zur klinischen Etablierung dieses Therapieverfahrens ebenso wie verschiedene nachfolgende Untersuchungen zur Optimierung der Hochdosischemotherapie. Eine "matched-pair" Analyse konnte zumindest im retro

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26

Gu, Xiaolian. "p63 and epithelial homeostasis studies of p63 under normal, hyper-proliferative and malignant conditions /." Doctoral thesis, Umeå : Umeå university, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-33894.

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27

Roussel, Francis. "Interactions cellulaires et couples lectine-sucre." Rouen, 1994. http://www.theses.fr/1994ROUE5071.

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L'expression de sucres de membrane (insolubles) par certaines cellules peut aller de pair avec l'expression de lectines endogènes (insolubles) par d'autres cellules. La complémentarité des deux réactifs solubles utilisés pour les mettre en évidence (lectines végétales, néoglycoprotéines) définit un couple lectine-sucre. L'interaction fonctionnelle ou plus banalement la complémentarité anatomique de ces deux cellules porteuses pose le problème de l'implication du couple lectine-sucre dans leur mise en place spécifique. Cette problématique a été explorée 1) au niveau de la voie sensitive doulour

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28

Freitas, Leandro Luiz Lopes de. "Analise imunoistoquimica de proteinas relacionadas ao ciclo celular (p53, Ki-67, bcl-2 e c-erbB-2) na transformação maligna do adenoma plenomorfico de glandula salivar." [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313780.

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Orientador: Albina Messias de Almeida Milani Altemani<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-06T19:08:01Z (GMT). No. of bitstreams: 1 Freitas_LeandroLuizLopesde_D.pdf: 4064664 bytes, checksum: d04222e584211904229193f280c217a9 (MD5) Previous issue date: 2006<br>Resumo: O adenoma pleomórfico (AP) é a neoplasia mais freqüente das glândulas salivares e o carcinoma ex-adenoma pleomórfico (CXAP) é a sua forma de transformação maligna mais comum. Os trabalhos da literatura com séries exclusivas de CXAP são poucos

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29

Nabavi, Roya. "Zur Problematik der Spätrezidive von Hodentumoren." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2005. http://dx.doi.org/10.18452/15337.

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Welche Ursachen führen bei Keimzelltumoren zu Spätrezidiven? Sind es ungünstige Tumorkonstellationen, Behandlungsfehler oder individuelle Faktoren, die zu Spätrezidiven von Keimzelltumoren (KZT) führen? Ziel der Untersuchung war es, diese Fragen zu beantworten, um Patienten zu identifizieren, für die sich daraus Konsequenzen in der Therapie und Verlaufskontrolle ergeben. Indem wir Spätrezidive nach 4 Jahren auswerteten, wollten wir die besonderen Merkmale dieser Patientengruppe herausarbeiten. Unter 759 erfassten Patienten sahen wir 165 Frührezidive (< 2 Jahre), 92 Rezidive nach 2 Jahren u

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30

Flaman, Jean-Michel. "La levure Saccharomyces cerevisiae : un modèle pour l'étude de l'activité transcriptionnelle de p53 et de son altération dans les cancers." Rouen, 1997. http://www.theses.fr/1997ROUES084.

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Les mutations du gène suppresseur de tumeur p53 représentent l'anomalie moléculaire la plus fréquemment observée dans les cancers suggérant que l'inactivation de ce gène constitue une étape clé de la transformation maligne. Le gène p53 code pour un facteur de transcription capable, en réponse à des conditions génotoxiques, de réguler l'expression des gènes p21 et Bax respectivement impliquées dans l'arrêt du cycle cellulaire et l'activation de l'apoptose. Les données à la fois structurales et fonctionnelles suggèrent que la conséquence majeure des mutations du gène p53 dans les cancers est la

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31

Fröhner, Michael, Oliver W. Hakenberg, and Manfred P. Wirth. "Molecular Therapy in Urologic Oncology." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-133789.

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During recent years, significant advances have been made in the field of molecular therapy in urologic oncology, mainly for advanced renal cell carcinoma. In this hitherto largely treatment-refractory disease, several agents have been developed targeting the von Hippel-Lindau metabolic pathway which is involved in carcinogenesis and progression of the majority of renal cell carcinomas. Although cure may not be expected, new drugs, such as the multikinase inhibitors sorafenib and sunitinib and the mammalian target of rapamycine inhibitor temsirolimus, frequently stabilize the disease course and

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32

Fröhner, Michael, Oliver W. Hakenberg, and Manfred P. Wirth. "Molecular Therapy in Urologic Oncology." Karger, 2007. https://tud.qucosa.de/id/qucosa%3A27535.

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During recent years, significant advances have been made in the field of molecular therapy in urologic oncology, mainly for advanced renal cell carcinoma. In this hitherto largely treatment-refractory disease, several agents have been developed targeting the von Hippel-Lindau metabolic pathway which is involved in carcinogenesis and progression of the majority of renal cell carcinomas. Although cure may not be expected, new drugs, such as the multikinase inhibitors sorafenib and sunitinib and the mammalian target of rapamycine inhibitor temsirolimus, frequently stabilize the disease course and

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33

Sundelin, Kaarina. "Head and Neck Cancer : Factors Affecting Tumour Growth." Doctoral thesis, Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med1032s.pdf.

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34

Craperi, Delphine. "Thérapie génique des gliomes : caractérisation des voies cytotoxiques déclenchées par le système thymidine kinase herpétique/ganciclovir." Université Joseph Fourier (Grenoble ; 1971-2015), 1998. http://www.theses.fr/1998GRE10073.

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La therapie genique par transfert du gene de la thymidine kinase du virus de l'herpes simplex de type 1 (hsv1-tk) suivi d'un traitement avec la prodrogue ganciclovir (gcv) a ete utilisee pour le traitement de divers cancers. L'efficacite de cette therapie est en partie due a l'existence d'un effet de toxicite de voisinage : le traitement au ganciclovir entraine non seulement la mort des cellules exprimant hsv1-tk mais aussi celle des cellules adjacentes non transfectees. Nous avons entrepris une etude in vitro des mecanismes moleculaires de la toxicite de ce systeme enzyme/prodrogue sur des li

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35

Mackenbach, Loue Petra. "Translocation nucléaire de la protéine kinase CK2 induite par les facteurs de croissance et surexpression d'une forme anormale de la kinase dans les tumeurs du sein." Université Joseph Fourier (Grenoble ; 1971-2015), 1997. http://www.theses.fr/1997GRE10164.

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La proteine kinase ck2 est une serine/threonine proteine kinase exprimee dans toutes les cellules eucaryotes. Elle est composee de deux sous-unites catalytiques (alpha et alpha') et deux sous-unites regulatrices beta. Des observations convergentes suggerent qu'elle doit jouer un role important dans le controle de la division cellulaire. Le but de notre travail etait de tenter de determiner la facon dont les facteurs de croissance peuvent reguler la ck2 dans la cellule. Dans un premier temps nous avons caracterise les differentes isoformes de la ck2 mais aucune distinction n'a ete detectee conc

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36

PERRIN, CHRISTELE. "Methodologie pour l'analyse quantitative en imagerie microscopique conventionnelle et a fluorescence. Application a l'etude de la proliferation et de l'expression du recepteur a l'egf dans des cellules tumorales mammaires." Université Joseph Fourier (Grenoble), 1996. http://www.theses.fr/1996GRE10198.

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L'utilisation accrue des methodes d'imagerie microscopique dans le domaine de la cancerologie, et les developpements recents des marqueurs specifiques utilises dans ce contexte ont fait naitre un besoin urgent en ce qui concerne le developpement de procedures de multi-marquages enzymatiques ou fluorescents, et leur quantification cellule a cellule. C'est dans ce contexte de mise au point methodologique qu'ont ete realises les travaux presentes dans cette these. Ils incluent les divers aspects de la standardisation de methodes de multi-marquages, l'adaptation des methodes d'imagerie pour la qua

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37

Fresneau, Brice. "Analyses pronostiques en oncologie pédiatrique : Identification de facteurs de susceptibilité tumorale ou individuelle à l’efficacité et/ou à la toxicité des traitements anticancéreux utilisés chez l’enfant Investigating the Heterogeneity of Alkylating Agents' Efficacy and Toxicity Between Sexes: A Systematic Review and Meta-Analysis of Randomized Trials Comparing Cyclophosphamide and Ifosfamide (MAIAGE Study) Is Alpha-Fetoprotein Decline a Prognostic Factor of Childhood Non-Seminomatous Germ Cell Tumours? Results of the French TGM95 Study New Insight into Severe Ototoxicity after Childhood Cancer. Is there an Impact of Melphalan and Busulfan? A French Childhood Cancer Survivor Study A Pharmacokinetic and Pharmacogenetic Analysis of Osteosarcoma Patients Treated with High-Dose Methotrexate: Data from the OS2006/Sarcoma-09 Trial." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASS034.

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Les progrès thérapeutiques en oncologie pédiatrique ont permis une amélioration des taux de survie qui dépassent aujourd’hui 80%. De façon à augmenter les taux de guérison et diminuer les complications et séquelles des traitements, des efforts collaboratifs internationaux ont permis le développement de protocoles thérapeutiques stratifiés sur les facteurs pronostiques majeurs incluant des facteurs biologiques tumoraux issus des analyses moléculaires et notamment génomiques. Cependant, si les traitements utilisés prennent de plus en plus en compte la biologie tumorale, leur adaptation aux facte

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38

Mathieu-Mahul, Danièle. "Analyse moleculaire d'anomalies chromosomiques specifiques d'hemopathies malignes humaines." Paris 7, 1987. http://www.theses.fr/1987PA077133.

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39

Cheradame, Stéphane. "Biomodulation du 5-fluorouracile par l'acide folinique et recherche des facteurs de prédiction de la sensibilité tumorale à cette association." Université Joseph Fourier (Grenoble ; 1971-2015), 1996. http://www.theses.fr/1996GRE10252.

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Le principal effet cytotoxique du 5-fluorouracile (5fu) s'exerce par inhibition de la thymidylate synthetase (ts). La formation d'un complexe ternaire intracellulaire entre la ts, un anabolite du 5fu le fluorodeoxyuridine monophosphate (fdump) et un folate reduit, le 5,10-methylenetetrahydrofolate (ch2fh4), bloque la synthese de thymidine et donc la formation d'adn. L'acide folinique (af) potentialise l'effet du 5fu en augmentant le pool intracellulaire de ch2fh4. Une concentration optimale de ch2fh4 sous forme polyglutamatee via la folylpolyglutamate synthetase (fpgs) est necessaire pour une

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40

PILLAI, Vinoshene. "Intravital two photon clcium imaging of glioblastoma mouse models." Doctoral thesis, Scuola Normale Superiore, 2021. http://hdl.handle.net/11384/109211.

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41

Guimarães, Rita Manuela Marques Castro. "The role of DNA modifying enzymes in malignant testicular germ cell tumors." Master's thesis, 2019. https://hdl.handle.net/10216/124853.

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42

Guimarães, Rita Manuela Marques Castro. "The role of DNA modifying enzymes in malignant testicular germ cell tumors." Dissertação, 2019. https://hdl.handle.net/10216/124853.

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43

Lobo, João Pedro da Silva Machado. "Uncovering novel prognostic and predictive epigenetic biomarkers in malignant testicular germ cell tumors." Doctoral thesis, 2021. https://hdl.handle.net/10216/136707.

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Ahmed, Manal Bayomi Mahmoud. "The susceptibility of primordial germ cells to malignant transformation and isolation and characterization of members of a new gene family differentially expressed in invasive and non-invasive immortalized male germ cells." Doctoral thesis, 2002. http://hdl.handle.net/11858/00-1735-0000-0006-ABE4-9.

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CORANO, SCHERI KATIA. "c-MET proto-oncogene in malignant testicular germ cell tumours." Doctoral thesis, 2018. http://hdl.handle.net/11573/1138706.

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THE THESIS EXPLAINED The biological issue: Testicular Germ Cell Tumours (TGCTs), seminomas and non-seminomas, represent the most frequent malignancy in Caucasian males (20–40 years). Even if diagnosed in an early stage, resulting in good prognosis, a small percentage of cases progress resulting in death in young men. It is commonly accepted that these cancers arise from a disturbed testicular embryonic niche, that leads to the block of gonocyte differentiation. The subsequent development of seminomas and non-seminomas is due to the combination of genetic, epigenetic and microenvironment-base

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Yang, Chun-Wei, and 楊君緯. "The role of FAM60A in germ cell tumor differentiation and growth." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/97502700830094250311.

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碩士<br>國立臺灣大學<br>病理學研究所<br>104<br>Germ cell tumors (GCTs) are a neoplasm derived from germ cells. Germ cell tumors can be benign or malignant. They usually occur in the gonads (ovary and testis). Germ cell tumors that originate outside the gonads are due to faulty cell migration during development of the embryo. Up to 80% of malignant GCTs have isochromosome 12p. Iso-chromosome 12p is a specific genetic marker of GCTs. Because the high frequency of gain of genetic material of 12p in testicular GCTs, we searched the Human Protein Atlas for the identification of the candidate oncogene in chromoso

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Rosta, Viktória, and Csilla Krausz. "Comprehensive analyses of genetic and clinical factors in patients affected by Testicular Germ Cell Tumor." Doctoral thesis, 2022. http://hdl.handle.net/2158/1263662.

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Introduction: Testicular Germ Cell Tumor (TGCT) is a multifactorial, polygenic, and complex disease. It is the most common malignancy of men in their reproductive ages. This neoplasm has one of the highest heritability (37–48,9%) based mainly on epidemiological and Genome-Wide Association Study data. Epidemiological studies support that there is an increased familial cancer risk among TGCT patients’ family members. However, the studies are heterogeneous and sometimes controversial. Despite of the growing body of evidence regarding the involvement of genetic factors in TGCT susceptibility, our

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Yueh, Kuo-Chu, and 樂國柱. "The Mechanism Study of Multi-Drug Resistance (MDR) in Human Brain Malignant Tumor Cell Lines." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/69073080952519430133.

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碩士<br>國防醫學院<br>病理及寄生蟲學研究所<br>85<br>Glioblastoma multiforme (GBM), a high-grade malignant brain tumor, has less than 10% of two-year survival rate. It owns a poor prognosis by current surgery, radiotherapy or chemotherapy, so it is important to find new therapy methods to cope with this malignancy. The purpose of this study is to investigate the possible mechanisms of Multi-Drug Resistance (MDR) of primary brain tumors by measurement of cellular P-glycoprotein, lung resistance-related protein (LRP), multidrug resistance-associated protein (MRP), DNA topoisomerase II (Topo II), glutathion S-tr

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"The role of DNA methylation in the regulation and action of microRNA in testicular germ cell tumor." 2014. http://repository.lib.cuhk.edu.hk/en/item/cuhk-1290659.

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It was previously demonstrated that miR-199a was down-regulated in testicular germ cell tumor (TGCT) partly caused by hypermethylation of its promoter. More detailed analyses showed that miR-199a-5p, one of its two derivatives, suppressed TGCT invasiveness and proliferation via directing targeting PODXL and MAFB. The biological role of the other derivative, miR-199a-3p in TGCT, remains largely uncharacterized. In this project we identified DNMT3A, the de novo methyltransferase, as a direct target of miR-199a-3p using a 3’-UTR reporter assay. In NT2 (NTera 2) and HT (Hs 1.Tes) cells, miR-199a-3

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Batich, Kristen Anne. "Enhancing Dendritic Cell Migration to Drive Antitumor Responses." Diss., 2017. http://hdl.handle.net/10161/10453.

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<p>The histologic subtypes of malignant glial neoplasms range from anaplastic astrocytoma to the most deadly World Health Organization (WHO) Grade IV glioblastoma (GBM), the most common primary brain tumor in adults. Over the past 40 years, only modest advancements in the treatment of GBM tumors have been reached. Current therapies are predominantly for palliative endpoints rather than curative, although some treatment modalities have been shown to extend survival in particular cases. Patients undergoing current standard of care therapy, including surgical resection, radiation therapy, and

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