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Journal articles on the topic 'Malignant vulvar neoplasm'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Samara, Mariam, Ema Somen, and Davor Mijatovic. "Patient with malignant vulvar neoplasm: case report." Acta Chirurgica Croatica 1 (November 3, 2019): 35–38. https://doi.org/10.5281/zenodo.3517775.

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<strong>Background:</strong> Vulvar carcinoma most often occurs on the outer surface area of the female genitalia. The vulva is the area of skin that surrounds the urethra and vagina, including the clitoris and labia. It is quite rare cancer of the female reproductive system and accounts for 3-4% of all genitourinary tract neoplasms. Though it can occur at any age, vulvar cancer is most common in older adults. When present in young women it is mostly associated with human papillomavirus (HPV)–related dysplasia. The most common histology is squamous cell carcinoma of the vulva. <strong>Ca

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2

Nastasi, María, Ernesto Lara, Rosa Mata, Carmen Silva, and Elianny Betancourt. "Carcinoma neuroendocrino de vulva, una entidad poco frecuente. Reporte del primer caso en Venezuela." Revista de Obstetricia y Ginecología de Venezuela 83, no. 02 (2023): 223–29. http://dx.doi.org/10.51288/00830213.

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Vulvar cancer represents 1% of cancers in women; vulvar neuroendocrine carcinoma is extremely rare, with less than 20 published cases. Its behavior is very aggressive, producing early local recurrences, lymph node and distant metastases. The case of a 60-year-old patient who consulted for a vulvar lesion of 6 months of evolution, with extension to the lower third of the urethra and vagina and left inguinal nodal plastron is described. The vulvar biopsy reported malignant round cell neoplasm and the immunohistochemistry result was compatible with neuroendocrine carcinoma. She received concurren

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3

Hasanzadeh, Malihe, Somayeh Moeindarbari, Leila Mousavi Seresht, Amir Hosein Jafarian, Anahita Hamidi, and Marjaneh Farazestanian. "Vulvar Leiomyomatosis: A Diagnostic Challenge Case Report." Current Women s Health Reviews 16, no. 1 (2020): 81–83. http://dx.doi.org/10.2174/1573404815666190128152642.

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Introduction: Vulvar leiomyomas are rare and usually misdiagnosed as Bartholin’s cyst on initial presentation. Leiomyoma of vulva accounts for only 0.03% of all gynecological neoplasm. Definite diagnosis is based on surgical excision of the tumor. The aim of this report is to introduce a case of leiomyoma of the vulva which was initially misdiagnosed as Bartholin’s cyst. Case Presentation: We present a case of a 36-year old virgin female (BMI>30) who was referred to the clinic with a 5-year history of left labial mass which was initially diagnosed as Bartholin’s cyst. The mass was removed a

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4

Fujioka, Masaki, Kenji Hayashida, and Chikako Murakami. "Vulvar reconstruction should be performed using gluteal-fold perforator flap because of less morbidities and complications." Revista do Colégio Brasileiro de Cirurgiões 41, no. 2 (2014): 134–36. http://dx.doi.org/10.1590/s0100-69912014000200011.

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5

Dykgraaf, R. H. M., M. M. S. Van Veen, E. E. C. Van Bekkum-De Jonge, J. Gerretsen, D. DE Jong, and C. W. Burger. "Pleomorphic adenoma of the vulva: a review illustrated by a clinical case." International Journal of Gynecologic Cancer 16, no. 2 (2006): 920–23. http://dx.doi.org/10.1136/ijgc-00009577-200603000-00076.

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The pleomorphic adenoma of the vulva is an extremely scarce diagnosis. This form of neoplasm is more frequently observed in other topographic sites of the human body. Treatment modalities largely derive from experiences with the pleomorphic adenoma located in these other sites. As a result of similarity with other tumors and scarcity of the neoplasm, the diagnosis of pleomorphic adenoma of the vulva is easily missed in daily routine practice. Recurrences of this neoplasm are frequently observed with an estimated incidence of malignant transformation of 25%. Addressing this previously mentioned

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Wohlmuth, Christoph, and Iris Wohlmuth-Wieser. "Gynecologic Malignancies in Children and Adolescents: How Common is the Uncommon?" Journal of Clinical Medicine 10, no. 4 (2021): 722. http://dx.doi.org/10.3390/jcm10040722.

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The aim of this study is to assess the projected incidence and prognostic indicators of gynecologic malignancies in the pediatric population. In this population-based retrospective cohort study, girls ≤18 years with ovarian, uterine, cervical, vaginal and vulvar malignancies diagnosed between 2000 and 2016 were identified from the Surveillance, Epidemiology and End Results (SEER)-18 registry. The Kaplan–Meier method was used to analyze overall survival (OS). The age-adjusted annual incidence of gynecologic malignancies was 6.7 per 1,000,000 females, with neoplasms of the ovary accounting for 8

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Zuhdy, Mohammad, Mona Zaky, Reham Alghandour, Gena Abdelazeem, Omar Hamdy, and Abdelhadi Shebl. "Non-Palpable Invasive Lobular Carcinoma Initially Diagnosed by Inguinal Lymph Node Biopsy." Annals of African Surgery 17, no. 2 (2020): 88–92. http://dx.doi.org/10.4314/aas.v17i2.11.

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Metastasis from breast cancer to the inguinal lymph nodes or the vulva is a rare event with very few cases reported in literature. A 38-year-old lady presented complaining of progressive abdominal enlargement. Physical examination was unremarkable apart from abdominal enlargement and enlarged right inguinal lymph node. Radiology showed marked ascites, omental thickening, bilateral small ovarian masses, suspicious right inguinal lymph node (LN) as well as breast fibrocystic disease. Cytological examination of the ascitic fluid revealed malignant cells. Core needle biopsy from the inguinal LN su

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8

Rexhepi, Meral, Elizabeta Trajkovska, Florin Besimi, and Nagip Rufati. "Giant Fibroepithelial Polyp of Vulva: A Case Report and Review of Literature." PRILOZI 39, no. 2-3 (2018): 127–30. http://dx.doi.org/10.2478/prilozi-2018-0051.

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Abstract Fibroepithelial stromal polyps of vulva are the type of mesenchymal lesion that typically occurs in women of reproductive period. They are common, usually small and hystologically benign. Larger lesions are rare and likely arise from proliferation of mesenchymal cells within the hormonally sensitive subepithelial stromal layer of the lower genital tract. We present a case of 16 year old female with a giant polypoid lesion of the vulva localized on the right labium. The mass measure was 18×12×3 cm. Total surgical resection of the lesion was performed. Histopathological examination repo

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9

Pakharukova, M. I., M. A. Kotugina, and E. I. Vainberg. "Analyzing the differences between the cytological and histological methods in the vulva malignant neoplasm diagnosis." CLINICAL AND EXPERIMENTAL MORPHOLOGY 10, no. 1 (2021): 41–49. http://dx.doi.org/10.31088/cem2021.10.1.41-49.

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Introduction. Vulvar cancer is a rare female genital tract tumor. Unfortunately, the final diagnosis is often made in the late stage despite the available visualization methods. It indicates the need to improve the early diagnosis methods. The aim of the study was to improve the efficiency of the cytological diagnosis of vulvar cancer and pre-cancerous lesions by comparing the cytological and histological findings and diagnoses and analyzing the differences. Materials and methods. A retrospective analysis of the biopsies, smears, and scrapings of 82 patients from 2014 to 2019 was carried out.

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Kornovski, Yavor, Yonka Ivanova, Stoyan Kostov, Stanislav Slavchev, and Angel Yordanov. "GYNAECOLOGICAL ONCOLOGIC DISEASES AND PREGNANCY." Wiadomości Lekarskie 74, no. 8 (2021): 1984–87. http://dx.doi.org/10.36740/wlek202108135.

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We review the current research literature on treatment behaviour for neoplasms of the female genital tract during pregnancy. Guidelines for clinical management of cervical cancer, ovarian tumours, and vulvar cancer are presented both regarding gynaecological oncologic treatment and obstetrics. Cervical cancer is the most common malignant tumour of the female genitalia during pregnancy due to the high incidence of this neoplasm in developing countries, including Bulgaria, on the one hand, and on the other, it affects women of reproductive age. Treatment algorithms depending on various factors –

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11

Xylouri, Chrysi, Damaskini Polychroni, and Athanasios Maurogiorgis. "Case report: A Large Fibroepithelial Polyp of the Vulva." Hellenic Journal of Obstetrics and Gynecology 23, no. 4 (2024): 281–86. http://dx.doi.org/10.33574/hjog.0577.

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Fibroepithelial polyps are one of the most common benign masses of the vulva and are characterized by relatively small size, vague symptomatology, and morphological diversity. These lesions mainly affect women of reproductive age and are hormone dependent. They are usually found around the urogenital area. A biopsy and histological examination are necessary to exclude the possibility of malignant neoplasm. The pathophysiology of the disease appears to be associated with the coexistence of diabetes mellitus, chronic inflammation and chronic friction. Below we will describe the case of a 17-year

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Sanjaya, I. Nyoman Hariyasa, Ryan Saktika Mulyana, Evert Solomon Pangkahila, and Hartanto Hartanto. "Congenital vulvar teratoma: a case report." Indonesian Journal of Perinatology 1, no. 1 (2020): 5–8. http://dx.doi.org/10.51559/inajperinatol.v1i1.2.

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Introduction: Teratoma is an embryonal neoplasm consisted of 3 germinal layers. Teratoma usually arises along the line of embryonic cleft and sinus closure formed by the fusion of skin during the embryonic development. In this case report, we present a case of fetal Teratoma on the vulval region, a very rare variant of the disease. Case: A 28-year-old woman came for a routine check-up for her first pregnancy at her 26th weeks of gestational age. On ultrasound examination, a mass was found around the fetal vulva. There was no mass or malformations on other body parts. Placenta and the amo

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13

Shkolnik, E., and D. Cai. "Characterization of A Rare Case of Vulvar Epithelioid Sarcoma with local recurrence and metastases." American Journal of Clinical Pathology 156, Supplement_1 (2021): S81. http://dx.doi.org/10.1093/ajcp/aqab191.171.

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Abstract Introduction/Objective Epithelioid sarcoma (ES) is a rare, malignant mesenchymal neoplasm that has a known tendency for local recurrence, regional lymph node involvement, and distant metastases. Two histologic variants have been recognized: classic ES also known as the distal type, and proximal-type ES (PES). The classic ES is common in young adults. It occurs more frequently in the distal upper extremities followed by the distal lower limbs and has a male prevalence of 2:1. Conversely, PES commonly involves deep tissues in the pelvic region, including the genital area. It tends to oc

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Blinov, D., A. S. olopova, E. Achkasov, T. Blbulyan, G. Bykovshchenko, and D. Petrenko. "Modern concept of rehabilitation of patients with vulvar cancer: the main trends and future ways of development." Vrach 34, no. 9 (2023): 5–12. http://dx.doi.org/10.29296/25877305-2023-10-01.

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Vulvar cancer (VC) is a relatively uncommon malignant neoplasm of the female genital system. However, the prevalence of human papillomavirus infection in women of reproductive age has been increasing, elevating the risk of this oncopathology. The treatment of VC, like many other malignant tumors, involves radical approaches that have a profound impact on various aspects of a woman's life. Surgical intervention significantly alters the anatomy of the external genitalia, leading to serious psycho-emotional disorders such as anxiety, depression, and body image dissatisfaction. Additionally, commo

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Alassfar, M., R. Rayes-Danan, A. Hammad, C. Abramovich, and S. Ganesan. "Vulvar Perivascular Epithelioid Cell Tumor: A Case Report of a Rare Neoplasm in an Uncommon Site." American Journal of Clinical Pathology 158, Supplement_1 (2022): S86—S87. http://dx.doi.org/10.1093/ajcp/aqac126.180.

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Abstract Introduction/Objective Perivascular epithelioid cell tumors (PEComas) are rare mesenchymal neoplasms that arise in a variety of soft tissue and visceral sites. In the female genital tract, PEComas arise in the uterine corpus and are rarely identified outside the uterus, with only a few cases reported in the vulva in the English literature. Methods/Case Report We report a case of a 75-year-old African American female, with a history of smoking and type II diabetes, who presented with a painless and mobile introital mass (2.5 cm). Incision and drainage were done, and a curettage sample

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Fabris, Isabella De Almeida, Marconi Rodrigues De Farias, Juliana Werner, et al. "Vulvar Lymphangiosarcoma in a Bitch." Acta Scientiae Veterinariae 45 (June 27, 2017): 6. http://dx.doi.org/10.22456/1679-9216.86087.

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Background: Lymphangiosarcoma (LSA) is a rare, highly malignant and infiltrative neoplasm of the lymphatic endothelium of dogs and cats. It is mostly reported in medium to large breed dogs, over 5-year-old, with no sexual predisposition. Affected animals present fluctuating and diffuse swelling, covering both dermis and subcutaneous tissue, spreading through lymphatic and haematic vessels. Histologically, LSA is characterized by connected channels devoid of conspicuous haematic elements. Treatment depends on location of the neoplasm, staging, and possibility of curative surgical excision. Chem

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17

Barretina Ginesta, Maria Pilar, Miguel Beltran, Maria Buxo, et al. "Second primary gynecologic neoplasms among breast cancer survivors." Journal of Clinical Oncology 30, no. 15_suppl (2012): 1588. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.1588.

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1588 Background: Excess of risk of several second primary malignancies after treatment for breast cancer (BC) has been reported. This risk can be related with shared risk factors, cancer susceptibility genes or prior treatments received. Hormonal factors and hormone therapy are known to be risk factors for both BC and some gynecological malignancies. The aim of this study was to asses gynecological cancer risk as a second neoplasm among BC patients in our population. Methods: Patients diagnosed with invasive BC (CIE10: C50.0-C50.9) and registered in the Girona Cancer Registry from 1980 to 2006

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18

Assis-Neto, Edgar Tavares de, Daniel de Araújo Viana, and Márcio César Vasconcelos Silva. "Bilateral ovarian dysgerminoma with metastasis in female dog's mesenteric lymph node: a case report." Brazilian Journal of Case Reports 1, no. 2 (2021): 32–41. http://dx.doi.org/10.52600/2763-583x.bjcr.2021.1.2.32-41.

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Dysgerminoma is a rare malignant neoplasm, associated with hormonal dysfunctions, which occurs in canine and feline females from middle age to elderly, without racial predisposition. In the present report, we described a case of ovarian dysgerminoma in a dog, only abdominal distension, persistent vulvar bloody discharge and apathy. The animal in question underwent exploratory laparotomy, where general neoformations were detected in the ovaries, and a lymph node with abnormal characteristics was also found. Therefore, surgery for ovariosalpingoisterectomy and puncture of a fragment of the lymph

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Bouceiro-Mendes, Rita, M. Mendonça-Sanches, Luís Soares-de-Almeida, Isabel Correia-Fonseca, and João Borges-da-Costa. "Vulvar Diseases that Required a Biopsy: A Retrospective Study." Journal of the Portuguese Society of Dermatology and Venereology 79, no. 4 (2021): 321–28. http://dx.doi.org/10.29021/spdv.79.4.1411.

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   Introduction: The vulvar area may be affected by many noninfectious conditions with similar clinical appearance, requiring a cutaneous biopsy. Our goal was to characterize the noninfectious vulvar diseases that required a biopsy in a southwestern Europe Central Hospital during a 10-year period. Methods: A retrospective study of all the noninfectious vulvar diseases with histological confirmation diagnosed in our institution was conducted between January 1, 2008 and December 31, 2017. Results: The sample included a total of 323 biopsies from 317 patients, aged b

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Baker, Gabrielle M., M. Angelica Selim, and Mai P. Hoang. "Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital." Archives of Pathology & Laboratory Medicine 137, no. 9 (2013): 1237–46. http://dx.doi.org/10.5858/arpa.2012-0434-oa.

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Context.—Because the skin and modified mucosal surfaces of the vulvar region contain dense apocrine glands and anogenital mammary-like glands, in addition to eccrine glands and folliculosebaceous units, benign as well as malignant lesions derived from these adnexal structures are, not surprisingly, found in the vulva. However, their incidence occurring in the vulva has not been reported, to our knowledge. Objective.—To determine the incidence of various vulvar adnexal lesions. Design.—We performed a retrospective review (1978–2010) of the cases at our institution. Results.—A total of 189 vulva

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Harshini, V., and Kishore Alva. "Case report: A case of Pseudoepitheliomatous hyperplasia of vulva, a differential diagnosis for squamous cell carcinoma of external genitalia in women." Southeast Asian Journal of Health Professional 5, no. 4 (2023): 100–101. http://dx.doi.org/10.18231/j.sajhp.2022.023.

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A woman presenting with vulval lesions is to be examined and evaluated further before giving her the definitive diagnosis and proposing treatment. As the differential diagnosis may vary from benign lesions like lichen sclerosus, vulval intraepithelial neoplasia or malignant lesions like squamous cell carcinoma. We are presenting a case report wherein 70 year woman presented with features similar to squamous cell carcinoma but was diagnosed as pseudoepitheliomatous hyperplasia of vulva which is a benign lesion.Pseudoepitheliomatous hyperplasia (PEH) is a benign condition, characterized by hyper

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Bal Gargade, Chitrawati, Archana Hemant Deshpande, and Seetu Palo. "Histopathological spectrum of vulvar lesions on a remote Indian Island." IP Archives of Cytology and Histopathology Research 6, no. 3 (2021): 153–59. http://dx.doi.org/10.18231/j.achr.2021.037.

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A wide spectrum of normal, benign, premalignant, and malignant lesions may occur on the vulva. Symptoms of vulvar disorders may be non-specific. Empiric treatment of vulvovaginal symptoms is common but usually not helpful. Though the varied clinical presentation and diverse histopathological spectrum of vulvar lesions have amazed Pathologists, only a few studies have been reported in the literature. The present study consists of a histopathological spectrum of vulvar lesions. 1.To evaluate the histopathological spectrum of vulvar lesions. 2. To compare the incidences of non-neoplastic and neop

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Trongpisutsak, Ananya, Patou Tantbirojn, and Ruangsak Lertkhachonsuk. "Proportion of vulvar premalignant and malignant lesions in overall vulvar specimens in Thailand." Asian Biomedicine 12, no. 6 (2019): 281–86. http://dx.doi.org/10.1515/abm-2019-0031.

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AbstractBackgroundVulvar lesion is one of the common gynecologic problems.ObjectiveTo assess the proportion of vulvar premalignant and malignant lesions in overall vulvar specimens and to evaluate the clinicopathologic features of each vulvar lesion in King Chulalongkorn Memorial Hospital (KCMH).MethodsPathological microscopic slides and medical records of the patients who underwent vulvar-related operations between January 1, 2002 and December 31, 2015 were reviewed. Patients’ clinical characteristics and pathologic features were evaluated and analyzed.ResultsA total number of 700 patients we

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Pant, P. R., J. Sharma, B. L. Manandhar, and A. Joshi. "Carcinoma of vulva occurs not only during old age: A Series of six cases." Journal of Institute of Medicine Nepal 35, no. 1 (2013): 71–73. http://dx.doi.org/10.59779/jiomnepal.598.

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Squamous cell carcinoma of the vulva is predominantly a disease of postmenopausal women; it accounts for 5% of all female genital malignant neoplasms. Postoperative recovery in two among the five operated patient was late as their vulval wound underwent dehiscence. Other three patients had an uneventful post operative period. Histopathology report showed Squamous cell carcinoma in all the cases. Lymphnodes was negative for malignant cells in all the cases.

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Rolfe, K. J., L. J. Eva, A. B. Maclean, J. C. Crow, C. W. Perrett, and W. M. N. Reid. "Cell cycle proteins as molecular markers of malignant change in vulvar lichen sclerosus." International Journal of Gynecologic Cancer 11, no. 2 (2001): 113–18. http://dx.doi.org/10.1136/ijgc-00009577-200103000-00004.

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Lichen sclerosus (LS) has a known association with the development of squamous cell carcinoma of the vulva. The purpose of this study was to investigate molecular markers, which could indicate premalignant changes. Multiple sequential vulvar biopsies were taken over a period of 11 years from a patient with longstanding LS. Immunohistochemical staining was used to demonstrate a range of molecular markers.Increased expression of p53 and Ki67 was found in areas of squamous hyperplasia (SH) and differentiated vulvar intraepithelial neoplasia (dVIN) which correlated with the subsequent development

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Allbritton, Jill I. "Vulvar Neoplasms, Benign and Malignant." Obstetrics and Gynecology Clinics of North America 44, no. 3 (2017): 339–52. http://dx.doi.org/10.1016/j.ogc.2017.04.002.

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Manuel, Vargas. "Clinical, Pathological, Preventive and Therapeutic Aspects in Cancer De Vulva." Obstetrics Gynecology and Reproductive Sciences 4, no. 1 (2020): 01–15. http://dx.doi.org/10.31579/2578-8965/036.

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Vulvar cancer is rare, occupies the fourth most common type of gynecological cancer mainly affects postmenopausal, there are no screening tests or effective strategies to reduce its incidence, only the timely treatment of preneoplastic lesions; It is initially asymptomatic, chronic pruritus or vulvar pain is reported, or the presence of tumor or ulcer; alone, the biopsy confirms the diagnosis and histopathological type. Surgical staging involves the removal of the primary lesion and locoregional lymph node evaluation. In current practice, surgical management is conservatively substituted for r

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Bahadur, Anupama, Rajlaxmi Mundhra, Ayush Heda, and Ashok Singh. "Large vulvar fibroepithelial polyp and review of differentials." BMJ Case Reports 17, no. 2 (2024): e259389. http://dx.doi.org/10.1136/bcr-2023-259389.

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Vulval fibroepithelial polyps (FEPs) are a rare type of vulval fibroblastic tumour commonly found in premenopausal women. It is important to obtain an accurate pathological diagnosis because, despite being benign, the condition shares some characteristics with malignant vulva lesions in its differential diagnosis. We present a case of young woman in her 20s with a giant FEP. After surgical excision, the patient did not manifest any signs of recurrence after 1-year follow-up. Our review focuses on the distinguishing characteristics of these rare neoplasms as we explore their differential diagno

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Pant, PR, J. Sharma, BL Manandhar, and A. Joshi. "Carcinoma of vulva occurs not only during old age: A Series of six cases." Journal of Institute of Medicine Nepal 35, no. 1 (2013): 71–73. http://dx.doi.org/10.3126/jiom.v35i1.8902.

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Squamous cell carcinoma of the vulva is predominantly a disease of postmenopausal women; it accounts for 5% of all female genital malignant neoplasms. Postoperative recovery in two among the five operated patient was late as their vulval wound underwent dehiscence. Other three patients had an uneventful post operative period. Histopathology report showed Squamous cell carcinoma in all the cases. Lymphnodes was negative for malignant cells in all the cases. DOI: http://dx.doi.org/10.2126/joim.v35i1.8902 Journal of Institute of Medicine, April, 2013; 35:71-73

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Klamminger, Gilbert Georg, Elke Eltze, Annick Bitterlich, et al. "Ki-67 as a Prognostic Marker in Squamous Cell Carcinomas of the Vulva: A Systematic Review." Journal of Clinical Medicine 14, no. 6 (2025): 2045. https://doi.org/10.3390/jcm14062045.

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Background/Objectives: To evaluate the prognostic impact of immunohistochemical ki-67 staining analysis regarding lymph node involvement and survival data (overall/progression-free survival) in squamous cell carcinoma of the vulva. Methods: A systematic literature search of English and German articles was conducted (PubMed, Embase, Scopus, Web of Science) from 1980 to December 2023, including the search terms “vulvar Neoplasms”, “vulvar cancer”, “vulvar carcinoma”, “vulvar tumor”, ”vulvar tumour”, “vulvar malignancy”, “vulvar malignant”, “ki-67”, “MIB-1”, “MIB1”, “proliferative index”, “prolif

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Ueda, Yutaka, Takayuki Enomoto, Toshihiro Kimura, Kiyoshi Yoshino, Masami Fujita, and Tadashi Kimura. "Two Distinct Pathways to Development of Squamous Cell Carcinoma of the Vulva." Journal of Skin Cancer 2011 (2011): 1–7. http://dx.doi.org/10.1155/2011/951250.

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Squamous cell carcinoma (SCC) accounts for approximately 95% of the malignant tumors of the vaginal vulva and is mostly found in elderly women. The future numbers of patients with vulvar SCC is expected to rise, mainly because of the proportional increase in the average age of the general population. Two different pathways for vulvar SCC have been put forth. The first pathway is triggered by infection with a high-risk-type Human Papillomavirus (HPV). Integration of the HPV DNA into the host genome leads to the development of a typical vulvar intraepithelial neoplasia (VIN), accompanied with ov

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Clemente, Nicolò, Andrea Ciavattini, Gaetano Valenti, et al. "Extramammary Paget’s Disease of the Vulva and Concomitant Premalignant/Malignant Vulvar Lesions: A Potential Challenge in Diagnosis and Treatment." Current Oncology 30, no. 1 (2023): 959–66. http://dx.doi.org/10.3390/curroncol30010073.

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The aim of the present study was to evaluate the incidence of concomitant vulvar cancers or premalignant lesions in women surgically treated for extramammary Paget’s disease of the vulva (EMPDV) through a multicenter case series. The medical records of all women diagnosed with and treated for EMPDV from January 2010 to December 2020 were retrospectively analyzed. Women with EMPDV and synchronous vulvar cancer, vulvar intraepithelial neoplasia (VIN) and/or lichen sclerosus (LS) at the histology report were included in the study. A total of 69 women eligible for the present study were considered

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Merabishvili, V. M., I. V. Berlev, A. F. Urmancheeva, E. V. Bakhidze, and E. A. Ulrikh. "Malignant neoplasms of the vulva: epidemiology and survival of patients in Russia (clinical-population study)." Tumors of female reproductive system 20, no. 4 (2024): 33–43. https://doi.org/10.17650/1994-4098-2024-20-4-33-43.

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Background. Malignant neoplasms of the vulva account for about 4 % of all gynecological cancer neoplasms. Every year in Russia more than 2000 new cases of vulvar cancer are registered, in the North-Western Federal Region of Russia (NWFRR)1 – more than 200 (2022). The incidence rate for Russia as a whole is within 2.5 cases per 100,000 female population (in the NWFRR – about 3,00/0000). Standardized incidence rates for Russia and the NWFRR are within 1.1 and 1.20/0000. Before the age of 30, vulvar cancer practically does not occur; the maximum number (200–300) of cases is registered mainly amon

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Apa, Jessa Karyl Rubenecia, and Jericho Thaddeus P. Luna. "Recurrent vulvar dysplasia after a prior carcinoma of the cervix: A case of field effect." Philippine Journal of Obstetrics and Gynecology 48, no. 3 (2024): 197–201. http://dx.doi.org/10.4103/pjog.pjog_28_24.

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Vulvar intraepithelial neoplasia (VIN) is a dysplastic condition of the squamous epithelium of the vulva. There are two types of VIN: high-grade squamous intraepithelial lesion of the vulva and VIN differentiated type (dDVIN). Management includes excision, laser ablation, and topical therapy. An excisional procedure used in VIN is simple local excision and partial or total skinning vulvectomy. Despite treatment, its recurrence is high. A G5P5 (5004) woman in her 60s presented with vulvar pruritus and vulvar pain of 2 years. She was treated for cervical adenocarcinoma Stage IB1 with surgery and

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Fracchioli, S., M. Puopolo, I. A. Rigault De La Longrais, et al. "Primary “breast-like” cancer of the vulva: a case report and critical review of the literature." International Journal of Gynecologic Cancer 16, Suppl 1 (2006): 423–28. http://dx.doi.org/10.1136/ijgc-00009577-200602001-00079.

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Ectopic mammary gland tissue in the vulva is an uncommon clinical or pathologic finding. Such ectopic tissue can be the site of the same physiologic and pathologic processes found in the normal breast. However, the occurrence of adenocarcinoma is very rare, the first case being reported by Greene in 1935. We here report the 16th case of primary “breast-like” cancer arising in the vulva, together with a critical review of the literature, in order to highlight the dilemmas of a clinical approach to this neoplasm. Clear guidelines for diagnosis and therapy are still unavailable. The main diagnost

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Pacífico, Fernando Augusto, Luciana Maria Queiroz de Oliveira Borges, Ismael Felipe Gonçalves Galvão, et al. "Úlcera vulvar, nem sempre uma Infecção Sexualmente Transmissível." Anais da Faculdade de Medicina de Olinda 1, no. 11 (2024): 103–9. http://dx.doi.org/10.56102/afmo.2024.314.

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O hidradenoma papilífero vulvar é uma neoplasia cutânea benigna e rara das glândulas sudoríparas apócrinas que comumente surge na região anogenital de mulheres em idade reprodutiva, entre 25 e 40 anos. Seu diagnóstico clínico pode ser difícil, sendo às vezes confundido com cistos da glândula de Bartholin, angioqueratomas de Fordyce, endometriose vulvar, dentre outras lesões vulvares malignas. O presente estudo relatou o quadro clínico, diagnóstico e tratamento de um caso de hidradenoma papilífero vulvar em paciente de 47 anos do sexo feminino. Nesse quadro, notou-se a importância dessa lesão c

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Woida, Francesca Maia, and Alfredo Ribeiro-Silva. "Adenoid Cystic Carcinoma of the Bartholin Gland: An Overview." Archives of Pathology & Laboratory Medicine 131, no. 5 (2007): 796–98. http://dx.doi.org/10.5858/2007-131-796-accotb.

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Abstract Vulvar carcinoma is the fourth most frequently encountered malignancy of the female reproductive tract. Among vulvar neoplasms, 0.1% to 5% are of Bartholin gland origin. Primary adenoid cystic carcinoma of the Bartholin gland is very rare. To date, only about 60 cases have been reported in the world literature. Microscopic examination reveals a neoplasm of cribriform pattern composed of nests and columns of cells of bland appearance arranged concentrically around glandlike spaces filled with eosinophilic periodic acid-Schiff–positive diastase-resistant material. Immunohistochemically,

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Dunaievska, V. V., and Ye O. Horkavyi. "An assessment of photodynamic therapy efficacy for the treatment of Bowen’s disease of the vulva." Zaporozhye Medical Journal 24, no. 1 (2022): 49–55. http://dx.doi.org/10.14739/2310-1210.2022.1.239492.

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Vulvar cancer occupied the 4th place (3–8 %) in the distribution of the malignant neoplasms of female genital organs, although this disease is considered to be rare. In the United States, about 4,000 new cases of vulvar cancer are diagnosed every year, and 850 women die from this cancer. An estimated 650 new cases of this disease are reported per year in Ukraine. One of the precancerous lesions of the vulva along with Paget’s disease is Bowen’s disease, which can progress to squamous cell carcinoma. Photodynamic therapy (PDT) is regarded as an effective method of this disease treatment in the

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Rolfe, K. J., J. C. Crow, E. Benjamin, W. M. N. Reid, A. B. Maclean, and C. W. Perrett. "Cyclin D1 and retinoblastoma protein in vulvar cancer and adjacent lesions." International Journal of Gynecologic Cancer 11, no. 5 (2001): 381–86. http://dx.doi.org/10.1136/ijgc-00009577-200109000-00007.

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Abnormalities in the cell cycle are associated with tumorigenesis but have not yet been identified in squamous cell carcinoma (SCC) of the vulva or in adjacent vulvar lesions. The purpose of this study was to identify cell cycle protein expression (cyclin D1 and retinoblastoma protein [pRb]) in vulvar SCC and in adjacent potentially premalignant lesions: lichen sclerosis (LS), squamous cell hyperplasia (SH), and vulvar intraepithelial neoplasia (VIN). Using immunohistochemical techniques, 57 SCCs were analyzed with 19 adjacent areas showing LS, 13 showing SH, 11 VIN, and six normal epithelium.

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Dunaevska, V. V., and O. M. Savluk. "THE INFLUENCE OF THE THYROID GLAND ON THE DEVELOPMENT OF THE SCLEROSING HULL OF THE VULVA IN WOMEN OF REPRODUCTIVE AGE." Клінічна та профілактична медицина 1, no. 19 (2022): 51–58. http://dx.doi.org/10.31612/2616-4868.1(19).2022.07.

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Sclerosing lichen (SL) of the external genitalia is a chronic slowly progressive disease with pronounced focal atrophy of the skin of the perineum and visible mucous membranes of the vulva and has two main peaks of clinical manifestations: childhood and perimenopausal age. It is associated with an increased risk of developing vulvar cancer, even though it is not a malignancy in itself. The true precursor of SL-associated cancer is intraepithelial vulvar neoplasia (VIN). The diagnosis is usually clinical, but in some cases a biopsy may be performed, especially to rule out VIN or cancer. In this

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Falcicchio, Giovanni, Lorenzo Vinci, Ettore Cicinelli, et al. "Vulvar Malignant Melanoma: A Narrative Review." Cancers 14, no. 21 (2022): 5217. http://dx.doi.org/10.3390/cancers14215217.

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Malignant melanoma is a fatal disease that affects all skin sites. Among these, vulvar melanoma (VM) is a rare gynecological condition that accounts for 5% of all vulvar neoplasms. VM primarily affects older Caucasian women and its relationship to sun exposure is undefined. Diagnosis is defined by biopsy but many clinical, dermatoscopic, and confocal microscopic features can guide doctors. The molecular profile is characterized by the KIT mutation, revealed by all of the technologies that are used (classical sequencing, next-generation sequencing, and immunohistochemical staining). BRAF and NR

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Kesić, Vesna, Pedro Vieira-Baptista, and Colleen K. Stockdale. "Early Diagnostics of Vulvar Intraepithelial Neoplasia." Cancers 14, no. 7 (2022): 1822. http://dx.doi.org/10.3390/cancers14071822.

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The spectrum of vulvar lesions ranges from infective and benign dermatologic conditions to vulvar precancer and invasive cancer. Distinction based on the characteristics of vulvar lesions is often not indicative of histology. Vulvoscopy is a useful tool in the examination of vulvar pathology. It is more complex than just colposcopic examination and presumes naked eye examination accompanied by magnification, when needed. Magnification can be achieved using a magnifying glass or a colposcope and may aid the evaluation when a premalignant or malignant lesion is suspected. It is a useful tool to

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Tipyakov, V. V. "CANCER VULVAE." Journal of obstetrics and women's diseases 6, no. 10 (2020): 940–42. http://dx.doi.org/10.17816/jowd610940-942.

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Occurs infrequently, according to L. Mayer's statistics on 35-40 cancerous lesions of the uterus, 1 malignant neoplasm of the outer parts of the female genital apparatus. Cancroid comes across more often; Mayer had a cancroid out of 9 cases - 6 times. The place of development and often serves as a large lip, at the bottom of the border, where the skin becomes mucous. Rokitanski once found the origin of the clitoris.

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Vergeychik, G. I., Z. A. Stribuk, V. F. Eryomin, С. Е. Шелкович, and V. I. Duda. "ESSENTIAL ROLE OF HUMAN PAPILLOMAVIRUS OF HIGH AND LOW ONCOGENIC RISK IN THE DEVELOPMENT OF GENITAL PAPILLOMAS, DISPLASIA AND CANCER OF VULVA." Health and Ecology Issues, no. 1S (December 28, 2010): 12–14. http://dx.doi.org/10.51523/2708-6011.2010-7-1s-1.

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The authors present the investigation results 49 patients with genital papillomas, leukoplakia, dysplasia and cancer of vulva and vagina. Based on the received data, one can suppose the essential role of HPV in the development of the lesions of vulva and vagina and reconsider the significance of the genotypes of high and low oncogenic risk in the development of non-malignant neoplasms, precancerous conditions and malignant growths of vulva and vagina.

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Lupi, Giovanni, Rui Jin, and Claudio Clemente. "Malignant Rhabdoid Tumor of the Vulva: A Case Report and Review of the Literature." Tumori Journal 82, no. 1 (1996): 93–95. http://dx.doi.org/10.1177/030089169608200120.

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Malignant rhabdoid tumor (MRT) is an uncommon aggressive neoplasm which usually occurs in the kidney of children, but it has also been found in extrarenal sites. MRT arising in the vulva is extremely rare. Only four cases of MRT of the vulva have been reported in the English literature. We herein present another case. The diagnosis and management of vulva MRT are reviewed.

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Menshikov, K. V., B. F. Kiyamov, and Т. К. Girfanov. "Videoendoscopic Inguinofemoral Lymphadenectomy for Vulvar Cancer. Literature Review." Creative surgery and oncology 15, no. 1 (2025): 41–49. https://doi.org/10.24060/2076-3093-2025-15-1-41-49.

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Vulvar cancer is one of the rare malignant neoplasms treated in gynecologic oncology. This type of cancer ranks nineteenth among the most common types of malignant neoplasms in European women. The main method for treating localized vulvar cancer is surgery. Starting from the stage TIb and with the lateral location of the tumor, surgical treatment is indicated (vulvectomy and inguinofemoral lymphadenectomy). The classical Ducuing surgical procedure, which was developed in 1934, is accompanied, in most cases, by such postoperative complications as lymphorrhea, delayed healing of surgical wounds,

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Lyalina, L. V., D. V. Kholopov, V. V. Khizha, E. V. Kasatkin, and Е. Е. Topuzov. "Gender features of malignant neoplasms associated with human papillo-mavirus in St. Petersburg." Perm Medical Journal 39, no. 4 (2022): 144–54. http://dx.doi.org/10.17816/pmj394144-154.

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Objective.To study the peculiarities of morbidity and mortality from malignant neoplasms associated with the human papillomavirus among male and female population in a megalopolis. The International Agency for Research on Cancer relates cancer of the oral cavity, tonsils and oropharynx, larynx, anal canal and skin of the perianal region, vulva, vagina, cervix and penis to malignant neoplasms associated with the human papillomavirus. Material and methods. The analysis of morbidity and mortality was carried out according to the Population Cancer Registry of St. Petersburg for the period 20

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Behranwala, K. A., B. Latifaj, P. Blake, D. P. J. Barton, J. H. Shepherd, and J. M. Thomas. "Vulvar soft tissue tumors." International Journal of Gynecologic Cancer 14, no. 1 (2004): 94–99. http://dx.doi.org/10.1136/ijgc-00009577-200401000-00012.

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ObjectiveTo report our incidence of soft tissue tumors at this site and to discuss various prognostic factors.MethodsAll patients with a diagnosis of vulvar soft tissue neoplasms were studied from a prospective database at the Royal Marsden Hospital between January 1985 and July 2001.ResultsSeventeen vulvar soft tissue neoplasms (11 malignant and six benign) were treated during this period. Leiomyosarcoma (n = 5) and aggressive angiomyxoma (n = 4) were the most frequent histologic types. According to the grade, there were four G3, three G2, three G1 and could not be assessed in one patient. Lo

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Khaniya, Bishal. "Histopathological Pattern of Gynecological Malignancies at Tribhuvan University Teaching Hospital, Nepal: A 3 years Study." Nepalese Medical Journal 4, no. 1 (2021): 442–45. http://dx.doi.org/10.3126/nmj.v4i1.37717.

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Introduction: Gynecological malignancies include malignancies affecting the female reproductive organs ovary, cervix, body of uterus, vulva, vagina, and gestational trophoblastic neoplasia. Materials and Methods: This is a hospital-based retrospective observational study of histopathological confirmed gynecological malignancies conducted in the department of Obstetrics and Gynecology, TUTH, Maharajgunj, Kathmandu for 3 years from April 2016 to March 2018. Results: Among 314 cases enrolled in the study, the most common gynecological malignancy was of ovary (50.63%), followed by the cervix (30.2

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Ochoa Amaya, Julieta E., Anita Roque Rodríguez, and Natalia Pedraza Castillo. "Histiocitosis sistémica maligna en un canino. Reporte de un caso." Revista Colombiana de Ciencias Pecuarias 22, no. 1 (2009): 13. http://dx.doi.org/10.17533/udea.rccp.324351.

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Summary The malignant systemic histiocytoses is a disease slightly common of dogs and cats, that has been characterize by the neoplasic proliferation of macrofhages in different organs and systems. The proliferative histiocytic disease can present nodular masses in lungs, liver, and lymphatic mediastines nodules, the dermis and epidermis are not very compromised. To the Veterinary Clinic of the Universidad de los Llanos arrived a female canine of 5 years old with depression, lack of appetite, abdominal distension, hyperventilation, purulent secretion by the vulva. With the necropsy was found a

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