Relevant bibliographies by topics / Malonates

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  2. Dissertations / Theses
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  5. Conference papers
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Academic literature on the topic 'Malonates'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 May 2024

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Journal articles on the topic "Malonates"

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Al-Najar, Anis A., and Awatif M. Ibrahim. "The audio frequency conductances of magnesium, manganese II, and barium malonates in aqueous medium at 25 °C." Canadian Journal of Chemistry 68, no. 5 (May 1, 1990): 770–73. http://dx.doi.org/10.1139/v90-121.

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The conductance of aqueous solutions of magnesium, manganese II, and barium malonates has been measured at 1.59 kHz, using a conventional audio frequency bridge. Conductance data were evaluated using different modern theoretical conductance equations, each a three-parameter equation in KA, Λ0, and a. These are the complete and expanded forms of both the Fuoss–Hsia (F/H) and Pitts (P) equations and the Lee–Wheaton (L/W) equation. Our results show that the Lee–Wheaton equation is the most satisfactory. Keywords: conductance, aqueous medium, magnesium malonate, manganese malonate, barium malonate.
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Khalaj, Mehdi, Nasrin Farahani, Mahdieh Sadeghpour, Halimeh Rajabzadeh, and Seyed Khatami. "PEG/ZnBr2-Assisted Multicomponent Reactions: A Novel Procedure for the Synthesis of Functionalized 5,6-Dihydropyran-2-ones." Synlett 29, no. 07 (January 30, 2018): 894–97. http://dx.doi.org/10.1055/s-0036-1591760.

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We report a catalytic multicomponent reaction of isocyanides, oxiranes, and malonates under mild conditions, allowing the transformation of a wide range of substrates into 5,6-dihydropyran-2-one products in acceptable yields. We have also examined the leaving group selectivity using an unsymmetrical malonate. This novel method demonstrates the benefits of combining different activation modes in oxiranes.
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Sharifi, Ali, Maryam Moazami, Mohammad Saeed Abaee, and Mojtaba Mirzaei. "Ionic liquid-catalyzed synthesis of (1,4-benzoxazin-3-yl) malonate derivatives via cross-dehydrogenative-coupling reactions." Heterocyclic Communications 28, no. 1 (January 1, 2022): 51–57. http://dx.doi.org/10.1515/hc-2022-0007.

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Abstract A convenient C(sp3)–C(sp3) oxidative dehydrogenative coupling reaction of 1,4-benzoxazin-2-ones with malonate esters was developed under mild conditions to obtain the respective ester malonates in high yields. Reactions take place in [omim]FeCl4, acting as both the solvent and the catalyst. Under [omim]Cl/FeCl3-DDQ conditions, derivatives of 1 coupled with malonate 2 to give the target molecules within 1–2 h time periods. The ionic liquid was recovered and reused in the next reactions without losing its efficiency.
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Wan, Yali, Zaifei Chen, Dingfu Liu, and Yizhu Lei. "Palladium Nanoparticles Supported on Triphenylphosphine-Functionalized Porous Polymer as an Active and Recyclable Catalyst for the Carbonylation of Chloroacetates." Catalysts 8, no. 12 (November 26, 2018): 586. http://dx.doi.org/10.3390/catal8120586.

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Dialkyl malonates are important organic intermediates that are widely used as building blocks in organic synthesis. Herein, palladium nanoparticles supported on a triphenylphosphine-functionalized porous polymer were successfully developed as an efficient and recyclable catalyst for the synthesis of dialkyl malonates via the catalytic carbonylation of chloroacetates. The influence of reaction parameters such as solvent, base, and promoter on activity was carefully investigated. With a 1 mol% of palladium usage, excellent yields of dialkyl malonates were obtained. Importantly, the catalyst can be easily separated and reused at least four times, without a significant loss in reactivity. Furthermore, the developed catalyst was also highly active for the alkoxycarbonylation of α-chloro ketones.
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Stadlbauer, Wolfgang, El-Sayed Badawey, Gerhard Hojas, Peter Roschger, and Thomas Kappe. "Malonates in Cyclocondensation Reactions." Molecules 6, no. 4 (March 31, 2001): 338–52. http://dx.doi.org/10.3390/60400338.

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Carano, Maurizio, Carlo Corvaja, Luigi Garlaschelli, Michele Maggini, Massimo Marcaccio, Francesco Paolucci, Dario Pasini, Pier Paolo Righetti, Elena Sartori, and Antonio Toffoletti. "Methanofullerenes from Macrocyclic Malonates." European Journal of Organic Chemistry 2003, no. 2 (January 2003): 374–84. http://dx.doi.org/10.1002/ejoc.200390044.

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Dürr, Eva-Maria, and Joanna F. McGouran. "Probing the Binding Requirements of Modified Nucleosides with the DNA Nuclease SNM1A." Molecules 26, no. 2 (January 9, 2021): 320. http://dx.doi.org/10.3390/molecules26020320.

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SNM1A is a nuclease that is implicated in DNA interstrand crosslink repair and, as such, its inhibition is of interest for overcoming resistance to chemotherapeutic crosslinking agents. However, the number and identity of the metal ion(s) in the active site of SNM1A are still unconfirmed, and only a limited number of inhibitors have been reported to date. Herein, we report the synthesis and evaluation of a family of malonate-based modified nucleosides to investigate the optimal positioning of metal-binding groups in nucleoside-derived inhibitors for SNM1A. These compounds include ester, carboxylate and hydroxamic acid malonate derivatives which were installed in the 5′-position or 3′-position of thymidine or as a linkage between two nucleosides. Evaluation as inhibitors of recombinant SNM1A showed that nine of the twelve compounds tested had an inhibitory effect at 1 mM concentration. The most potent compound contains a hydroxamic acid malonate group at the 5′-position. Overall, our studies advance the understanding of requirements for nucleoside-derived inhibitors for SNM1A and indicate that groups containing a negatively charged group in close proximity to a metal chelator, such as hydroxamic acid malonates, are promising structures in the design of inhibitors.
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Dürr, Eva-Maria, and Joanna F. McGouran. "Probing the Binding Requirements of Modified Nucleosides with the DNA Nuclease SNM1A." Molecules 26, no. 2 (January 9, 2021): 320. http://dx.doi.org/10.3390/molecules26020320.

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SNM1A is a nuclease that is implicated in DNA interstrand crosslink repair and, as such, its inhibition is of interest for overcoming resistance to chemotherapeutic crosslinking agents. However, the number and identity of the metal ion(s) in the active site of SNM1A are still unconfirmed, and only a limited number of inhibitors have been reported to date. Herein, we report the synthesis and evaluation of a family of malonate-based modified nucleosides to investigate the optimal positioning of metal-binding groups in nucleoside-derived inhibitors for SNM1A. These compounds include ester, carboxylate and hydroxamic acid malonate derivatives which were installed in the 5′-position or 3′-position of thymidine or as a linkage between two nucleosides. Evaluation as inhibitors of recombinant SNM1A showed that nine of the twelve compounds tested had an inhibitory effect at 1 mM concentration. The most potent compound contains a hydroxamic acid malonate group at the 5′-position. Overall, our studies advance the understanding of requirements for nucleoside-derived inhibitors for SNM1A and indicate that groups containing a negatively charged group in close proximity to a metal chelator, such as hydroxamic acid malonates, are promising structures in the design of inhibitors.
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Kędra, Karolina, Marzena Łazarczyk, Tajana Begović, Danijel Namjesnik, Karolina Lament, Wojciech Piasecki, and Piotr Zarzycki. "Electrochemical Perspective on Hematite–Malonate Interactions." Colloids and Interfaces 5, no. 4 (October 31, 2021): 47. http://dx.doi.org/10.3390/colloids5040047.

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Organic matter (OM) interactions with minerals are essential in OM preservation against decomposition in the environment. Here, by combining potentiometric and electrophoretic measurements, we probed the mode of coordination and the role of pH-dependent electrostatic interactions between organic acids and an iron oxide surface. Specifically, we show that malonate ions adsorbed to a hematite surface in a wide pH window between 3 and 8.7 (point of zero charge). The mode of interactions varied with this pH range and depended on the acid and surface acidity constants. In the acidic environment, hematite surface potential was highly positive (+47 mV, pH 3). At pH < 4 malonate adsorption reduced the surface potential (+30 mV at pH 3) but had a negligible effect on the diffuse layer potential, consistent with the inner-sphere malonate complexation. Here, the specific and electrostatic interactions were responsible for the malonate partial dehydration and surface accumulation. These interactions weakened with an increasing pH and near PZC, the hematite surface charge was neutral on average. Adsorbed malonates started to desorb from the surface with less pronounced accumulation in the diffuse layer, which was reflected in zeta potential values. The transition between specific and non-specific sorption regimes was smooth, suggesting the coexistence of the inner- and outer-sphere complexes with a relative ratio that varied with pH.
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Barton, Derek H. R., Pascal Langlois, Takashi Okano, and Nubar Ozbalik. "An unusual synthesis of malonates." Tetrahedron Letters 31, no. 3 (January 1990): 325–26. http://dx.doi.org/10.1016/s0040-4039(00)94545-3.

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Dissertations / Theses on the topic "Malonates"

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Viola, Angelo <1985&gt. "Alkylidene malonates and acetoacetates as intermediates for the preparation of bioactive molecules." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6344/1/Viola_Angelo_Tesi.pdf.

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In this thesis we investigated the versatility and the potential applications of different kinds of alkylidene malonates, acetoacetates, malonamides and acetoacetoamides. Our research group devoted great attention to this kind of compounds since alkylidenes can be considered important intermediates in the synthesis of several scaffolds, to be inserted into molecules of potential biological and pharmaceutical interest. The increasing use of alkylidenes is due to their ability to react as unsaturated electrophiles and to the possibility to exploit them as intermediates for the introduction of different kind of functionalities.The preparation of alkylidene malonates, acetoacetates, malonamides and acetoacetoamides is presented in chapter 1. This section deals with different preparation methods of alkylidenes that we developed during the last few years and to the technologies involved for each synthetic protocol. The reactivity that allowed to use the alkylidenes as intermediates in the synthesis of scaffolds for biologically active compounds is shown in chapter 2. In particular, we will discuss the most important reactions used to obtain the desired molecules, and we will focus on the most interesting aspects of these latter ones. Finally, chapter 3 will illustrate the potential applications and the related syntheses of potential bioactive compounds. The synthesized molecules find application in several fields and for this reason we considered each class of compounds in its related branch of interest.
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Viola, Angelo <1985&gt. "Alkylidene malonates and acetoacetates as intermediates for the preparation of bioactive molecules." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6344/.

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In this thesis we investigated the versatility and the potential applications of different kinds of alkylidene malonates, acetoacetates, malonamides and acetoacetoamides. Our research group devoted great attention to this kind of compounds since alkylidenes can be considered important intermediates in the synthesis of several scaffolds, to be inserted into molecules of potential biological and pharmaceutical interest. The increasing use of alkylidenes is due to their ability to react as unsaturated electrophiles and to the possibility to exploit them as intermediates for the introduction of different kind of functionalities.The preparation of alkylidene malonates, acetoacetates, malonamides and acetoacetoamides is presented in chapter 1. This section deals with different preparation methods of alkylidenes that we developed during the last few years and to the technologies involved for each synthetic protocol. The reactivity that allowed to use the alkylidenes as intermediates in the synthesis of scaffolds for biologically active compounds is shown in chapter 2. In particular, we will discuss the most important reactions used to obtain the desired molecules, and we will focus on the most interesting aspects of these latter ones. Finally, chapter 3 will illustrate the potential applications and the related syntheses of potential bioactive compounds. The synthesized molecules find application in several fields and for this reason we considered each class of compounds in its related branch of interest.
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Marrot, Florent. "Etude des malonates et squarates de lanthanoi͏̈de comme précurseurs des sulfures et oxysulfures correspondants." Toulouse 3, 1994. http://www.theses.fr/1994TOU30207.

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Cette recherche s'inscrit dans le cadre de l'elaboration de materiaux a partir de complexes de coordination, par le biais d'une degradation thermique en atmosphere controlee, a des temperatures aussi basses que possible. L'objectif particulier recherche vise a l'obtention de sulfures de terre-rare a partir des malonates ou squarates de ces elements. Les structures de deux complexes malonate de lanthane penta-hydrate et de deux complexes malonate mixtes de lanthane et de cuivre ont ete determinees. Toutes ces structures presentent des feuillets denses charges positivement dans lesquels le ligand malonate reunit quatre centres metalliques. La connexion entre ces feuillets se fait soit par un anion malonate soit par une entite dimalonate de cuivre. La synthese et l'etude structurale d'un malonate bimalonate de lanthane ont egalement ete realisees. Ce compose presente un caractere monodimensionnel marque. Deux familles de squarates de lanthanoide et d'ammonium, dependant du rayon ionique de la terre-rare, ont ete mises en evidence et leurs structures cristallines determinees. L'une est monodimensionnelle avec developpement de chaines en zigzag, l'autre est bidimensionnelle avec presence de feuillets ; l'electroneutralite est assuree par les ions ammonium. La degradation thermique de ces complexes, sous atmosphere d'azote et de soufre permet d'obtenir les sesquisulfures, phase beta, du lanthane au gadolinium, ou les oxysulfures, du dysprosium a l'ytterbium, par traitement de deux heures a partir de 700c ; ce qui represente un avantage certain par rapport aux methodes conventionnellement employees. La phase haute temperature gamma du sesquisulfure de cerium (1200-1300c) peut etre utilisee en tant que pigment rouge, en remplacement du sulfoseleniure de cadmium qui tend a etre interdit. Nous avons reussi a stabiliser cette phase a l'aide de dopants judicieusement choisis vers 600c et a controler la morphologie des poudres obtenues. Cette partie de la these doit demeurer confidentielle
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Fallan, Charlene. "Ytterbium-catalysed conjugate allylation of alkylidene malonates and enantioselective nickel-catalysed Michael additions of azaarylacetates and acetamides to nitroalkenes." Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/7683.

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I. Catalytic Conjugate Allylation of Alkylidene Malonates Nucleophilic conjugate addition of allylsilanes and allylstannanes to alkylidene malonates under the action of ytterbium catalysis in the presence of hexafluoro-isopropanol has been developed. Enantioselective conjugate allylation of alkylidene malonates under ytterbium or scandium catalysis using chiral bis(oxazoline) ligands allows access to the conjugate addition products in an enantiomerically-enriched form. Furthermore, elaboration of the allylated substrates via decarboxylation and an oxidative cleavage was demonstrated. II. Catalytic Enantioselective Conjugate Addition of Azaarylacetates and Acetamides to Nitroalkenes An enantioselective nickel-catalysed Michael addition of azaarylacetates and acetamides to nitroalkenes has been developed. A range of azaaryl pronucleophiles were shown to react with a variety of nitroalkenes to generate highly functionalised Michael addition products with impressive diastereo- and enantiocontrol. A possible mechanism for this process is proposed and crystal structures of the addition products have also been attained, allowing determination of the absolute stereochemistry. Elaboration and further functionalisation of these products was also possible under a range of conditions.
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Ultchak, Flaviana Salles. "Equilibrio liquido-vapor dos sistemas n-butanol : dimetilmalonato ou dietilmalonato as pressões de 100 e 200mmHg." [s.n.], 2000. http://repositorio.unicamp.br/jspui/handle/REPOSIP/267645.

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Orientador: Maria Alvina Krahenbuhl
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Quimica
Made available in DSpace on 2018-08-12T02:24:53Z (GMT). No. of bitstreams: 1 Ultchak_FlavianaSalles_M.pdf: 2164181 bytes, checksum: f1468bdd0cb3489326bd20f27ce9101c (MD5) Previous issue date: 2000
Resumo: Dados de equilíbrio de fases são úteis no projeto e otimização de processos que envolvem separação de fases, como destilação e extração. Malonatos são substâncias orgânicas que atuam como importantes intermediários em várias reações, como na produção de tintas, fármacos, pesticidas e aromas. Mesmo assim, as propriedades físicas dos malonatos são escassas na literatura. Este trabalho tem como objetivo obter as curvas de equilíbrio líquido-vapor isobáricas para três sistemas: dimetilmalonato/n-butanol a 100 e 20OmmHg, dietilmalonato/n-butanol a 200mmHg. Foi utilizado um ebuliômetro de recirculação de fases, da marca comercial "Normag". As concentrações das fases líquidas e vapor foram obtidas por cromatografia gasosa. Observou-se que ocorria uma reação química durante os experimentos, mas que não impediu o desenvolvimento do trabalho. A consistência termodinâmica foi testada pelo método de van Ness-Fredenslund (1977) e os parâmetros de interação binária do coeficiente de atividade para os modelos Wilson, UNIQUAC e NRTL foram estimados pelo método da máxima verossimilhança de acordo com Stragevitch (1997). Apesar da reação química, os dados obtidos são consistentes de acordo com os critérios adotados, mas observou-se que com o aumento da ftação molar do malonato presente, a partir de 0,5, a qualidade dos dados foi prejudicada pela reação química
Abstract: Phase equilibrium data are useful in the project and optimization of process that inc1udes phases separation, such as distillation and extraction. Malonates are organic substances that participate as an important intennediate in production reactions, like as ink, pharmaceuticals, pesticides and ftagrances. However their properties are rare in scientific literature. In this work the isobaric curves ofvapor-liquid equilibrium were measured for three systems: (I) dimethyl malonate+l-butanol at 100 mmHg, (2) dimethyl malonate+l-butanol at 200 mmHg and (3) diethyl malonate+l-butanol at 200 mmHg. Each system was measured by means of an ebuliometer with phase circulation (NORMAG). The liquid and vapor phase concentration was obtained by gaseous chromatography. A chemical reaction was verified during the experiments, but it didn't impede the work development. The thermodynamic consistency of the data was tested using the van Ness-Fredenslund method (1977) and the binary interaction parameters ofthe activity coefficient for the WILSON, UNIQUAC and NRTL models were calculated by the Maximum Likelihood Method in agreement with Stragevitch (1997). However a reaction inside of the equipment occurred during the experimental measurements, the results were considered consistent in agreement with the adopted rules in this work, but was verified that the data quality was impaired by chemical reaction with the increase ofmolar ftaction ofthe malonate, after 0,5
Mestrado
Desenvolvimento de Processos Químicos
Mestre em Engenharia Química
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Pailloux, Sylvie. "Conception, synthèse et évaluation pharmacologique de ligands des PPARs (Peroxisome Proliferator-Activated Receptors)." Lille 2, 2003. http://www.theses.fr/2003LIL2MT22.

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L'obésité, le diabète de type 2 et de nombreuses maladies inflammatoires comme l'athérosclérose, sont des pathologies en forte progression depuis ces dix dernières années. Il apparaît que les PPARs (Peroxisome Proliferator-Activated Receptors) interviennent dans la régulation de gènes influençant ces pathologies. Ces facteurs de transcription s'hétérodimérisent avec un autre récepteur nucléaire RXR (récepteur aux acides rétinoïques), après qu'ils soient activés par leurs ligands. Le complexe formé se fixe sur son PPRE (élément de réponse des PPARs) et recrute de nombreux co-facteurs. A partir de travaux antérieurs, une étude suivant le modèle de Topliss a été réalisé sur des structures diesters maloniques. La nécessité d'obtenir des ligands d'activité mixte PPARα/γ, nous a conduit à moduler l'extrémité malonate des composés précédents en acides esters, amides esters, acides, amides, nitriles et tétrazoles, en série benzothiazolinone, 6-benzoylbenzothiazolinone et 5-benzoylbenzothiazolinone. L'ensemble de ces molécules a été ou est encore testé, in vitro et in vivo, par les laboratoires SERVIER, afin de déterminer leurs activités sur PPARα et PPARγ, ainsi que leurs effets sur des marqueurs biologiques tel que les triglycérides, le glucose, la résistance à l'insuline
Obesity, diabetes (type 2), and many inflammatory illnesses such as arthrosclerosis have become pathologies of great interest over the last ten years. It appears that PPARs (Peroxisome Proliferator-Activated Receptors) play a role in the regulation of genes that influence these pathologies. These transcription factors heterodimerize with another nuclear receptor called RXR (Retinoidal X Receptor), after their activation by their ligands. The complex which forms fixes on PPREs (PPAR response elements) and recruits numerous co-factors. From previous work a study following Topliss was undertaken on the malonic diester structures. The need for ligands which have an activity dual PPARα/γ, led us to modulate the extremity of the malonate to acid esters, amide esters, acids, amides, nitrile tetrazoles, to a series benzothiazolinone, and to 5- and 6- benzoylbenzothiazolinone. All of these molecules have or are being tested in vitro and in vivo by the « laboratoires Servier », in order to determine their activities on PPARα and PPARγ, as well as their effects on biomarkers such as triglycerides, glucose, and insulin resistance
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Ahouari, Hania. "Exploration de nouveaux matériaux d'électrodes positives à base de polyanions carboxylates (oxalates, malonates et carbonates) et de métaux de transition." Thesis, Amiens, 2015. http://www.theses.fr/2015AMIE0027/document.

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Dans cette thèse, nous avons exploré toute une palette de composés à base de métaux de transition et de polyanions carboxylates (oxalates, malonates et carbonates) préparés via des procédés éco-efficaces. La synthèse du composé oxalate de fer (III) (Fe2(C2O4)3·4H2O) dont nous en avons élucidé pour la première fois la structure cristalline en combinant les techniques de diffraction des rayons X et neutrons, fait l'objet de la première partie de cette étude. Ce composé cristallise dans une maille triclinique (P -1) et il présente des propriétés électrochimiques intéressantes (98 mAh/g à 3.35 V vs. Li+/Li0). Dans cette quête pour de meilleurs matériaux, nous avons exploré la famille des oxalates Na2M2(C2O4)3·2H2O, dont la synthèse avait été déjà rapportée, mais sans qu'aucune activité électrochimique ne puisse être détectée. En revanche, le remplacement du groupement oxalate par un groupement malonate nous a permis d’obtenir pour la première fois plusieurs membres de la famille (Na2M(H2C3O4)2·nH2O (n=0, 2), M= Mn, Fe, Co, Ni, Zn et Mg) dont nous avons résolu leurs structures cristallines correspondantes. Cependant, comme dans le cas des oxalates, ces phases ne dévoilent aucune activité électrochimique vis-à-vis du lithium, bien qu'elles présentent des propriétés magnétiques intéressantes. Enfin nous avons conclu ce travail par la synthèse de composés appartenant à la famille des fluorocarbonates KMCO3F (M= Ca et Mn) en utilisant la voie tout solide. La phase au calcium, déjà rapportée dans la littérature, a fait l'objet d'une étude en température qui nous a permis de mettre en évidence pour la première fois la formation d'une phase haute température (KCaCO3F-HT), pour T≥320°C, dont nous avons résolu la structure. Finalement, l'utilisation du Mn au lieu du Ca a conduit à l'obtention d'une nouvelle phase (KMnCO3F) qui cristallise dans une maille hexagonale (P -6 c 2)
This thesis has focused on the exploration of new compounds based on 3d-metal and carboxylate polyanions (oxalates, malonates and carbonates) prepared through different sustainable synthetic approaches. In the first part, we report a new synthetic route to prepare the iron (III) oxalate compound (Fe2(C2O4)3·4H2O) and solve its crystal structure through combined X-ray and neutron powder diffraction. The compound crystallizes within a triclinic cell (P-1) and exhibits attractive electrochemical properties (98 mAh/g at 3.35 V vs. Li+/Li0). Motivated by this finding we pursued our quest for new positive electrode materials. We prepared by hydrothermal synthesis single crystals of sodium 3d-metal oxalates Na2M2(C2O4)3·2H2O, which are widely investigated in the literature for their magnetic properties. Unfortunately, these phases are electrochemically inactive versus lithium. Thereafter, we extended the synthesis towards the malonate family and we reported for the first time several members (Na2M(H2C3O4)2·nH2O (n= 0, 2), M= Mn, Fe, Co, Ni, Zn et Mg). These systems present rich crystal chemistry together with interesting antiferromagnetic properties but as in the case of the oxalates, they are not electrochemically active versus lithium. Finally, we synthesized two members of fluorocarbonates compounds KMCO3F (M= Ca and Mn) using solid state process. We succeeded in the preparation of the calcium member, already reported in the literature and we identified for the first time a phase transition at 320°C. The crystal structure of the high temperature phase (KCaCO3F-HT) was solved using neutron powder diffraction. A new manganese phase (KMnCO3F) was synthesized using the same technique and its crystal structure was solved by combining TEM, XR and neutrons powder diffraction techniques. This compound crystallizes within a hexagonal unit cell (P -6 c 2)
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Buchanan, D. J. "Diastereoselective oxy-Michael addition of a new chiral water equivalent to electron deficient alkenes : synthesis of 1,2-amino alcohols and b-hydroxy malonates." Thesis, University of Cambridge, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.597051.

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Chapters 1 and 2: An introduction to the intermolecular oxy-Michael reaction and a brief overview of the methods used to synthesise 1,2-amino alcohols. Chapter 3: An oxy-Michael reaction was developed whereby the addition of (S)-6-methyltetrahydropyran into a,b-unsaturated monosubstituted nitro compounds allowed rapid access to synthetically important 1,2-amino alcohols. Chapter 4: A logical advancement of the oxy-Michael addition was the addition into a,b-unsaturated disubstituted nitro compounds. These molecules were also converted into the corresponding 1,2-amino alcohols. In addition sequential treatment of the oxy-Michael adduct with TPAP yielded the corresponding b-hydroxy ketone motif. Chapters 5 and 6: The highly stereoselective total syntheses of (R)-pronethalol and (R)-salmeterol were achieved using the new oxy-Michael method as the key step. Chapter 7: An expansion of the methodology to incorporate other conjugate acceptors was considered important. However, analogous d-lactol oxy-Michael additions into crotonate ester and pentenolide were unsuccessful. However, successful oxy-Michael addition into symmetrical a,b-unsaturated malonate systems yielded THP* protected b-hydroxy malonates. It is believed that such motifs shall be capable of transformation into b-hydroxy esters after further development.
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ARZEL, PHILIPPE. "Construction asymetrique de carbones quaternaires benzyliques a partir de malonates et de diols prochiraux : application a la synthese selective d'alcaloides benzomorphanes (aphanorphine, eptazocine, ), de pyrrolidines et de piperidines (picenadol)." Paris 11, 1998. http://www.theses.fr/1998PA112329.

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Le travail rapporte concerne la preparation enantioselective de synthons possedant un carbone quaternaire benzylique chiral de hautes puretes enantiomeriques par voie enzymatique a partir de composes prochiraux (malonates, propane-1,3-diols 2,2-disubstitues, diols bicycliques) ainsi que leur application a la synthese d'heterocycle azotes biologiquement actifs. Dans la premiere partie sont exposees les preparations d'un hemiester chiral par hydrolyse enzymatique et de deux monoacetates benzyliques chiraux par transesterification enzymatique. Les reductions chimioselectives des fonctions acide et ester de l'hemiester permettent de preparer les deux formes enantiomeres de l'aphanorphine et de l'eptazocine, composes de type benzomorphane possedant une activite analgesique. Plusieurs voies d'acces a des alcools di- et tetrahydronaphtaleniques, precurseurs directs de ces composes, sont decrites a partir de l'hemiester et du monoacetate bicyclique respectivement de 97 et 93% d'ee. La synthese totale d'un derive dihydroxyle de l'aphanorphine est exposee. Dans un deuxieme temps, est decrite la preparation de synthons chiraux avec variation de la chaine alkyle (propyle, allyle), de la nature et du nombre des substituants aromatiques (3-methoxy-ou 3,4-dichloro-). La preparation de ces synthons permet une generalisation partielle de la methode de synthese par voie enzymatique. Une etude en modelisation moleculaire sur la reactivite de certains substrats avec l'esterase de foie de porc a ete realisee. L'acide (r)-(+)-2-(methoxycarbonyl)-2-(3-methoxyphenyl)pent-4-enoique, compose obtenu avec la plus grande purete enantiomerique, est utilise pour la synthese d'un ether d'enol, intermediaire commun permettant d'acceder en un seul pot, soit a une pyrrolidine, precurseur direct du profadol, soit a un lactame, precurseur potentiel du picenadol (piperidine). Tous ces composes ainsi que leurs intermediaires possedent de tres bons exces enantiomeriques (ee superieur a 86%).
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10

Donnici, Claudio Luis. "Caminhos sintéticos para obtenção de ésteres e tioésteres - α-metilsulfonil-α-metiltio-substituídos, precursores dos derivados α-ceto-carbocxílicos correspondentes." Universidade de São Paulo, 1993. http://www.teses.usp.br/teses/disponiveis/46/46135/tde-23062015-131015/.

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Este trabalho apresenta: 1) Duas revisões bibliográficas sendo uma sobre a síntese de α-ceto-tioésteres e -ésteres e a outra sobre a decomposição de sulfóxidos e sulfonas sulfeniladas; 2) Investigações prévias indicando a viabilidade da decomposição térmica e a estabilidade relativa dos derivados bissulfenilados de tioésteres de diferentes estados de oxidação Ia-e, obtidos a partir do α-ceto-tioéster; 3) O estudo de síntese de precursores de α-ceto-tioésteres II e α-ceto-ésteres III, a saber: α - metilsulfonil- α - metiltio tioésteres IVa-c, -éster V e α, α - dimetiltio - ésteres VIa-c; 4) Decomposição térmica de α-metilsulfonil-α-metiltio-tioésteres Iva, b e c e -éster V sintetizados aos α-ceto-tioésteres e ésteres correspondentes, pelo emprego do método elaborado anteriormente por Wladislaw e col. e sugestão do mecanismo da mesma. A síntese de α metilsulfonil α metiltio tiopropionato de etila (Ivb), foi efetuada a partir do ácido α-cloro propiônico através de quatro passos reacionais, a saber: sulfenilação por substituição, oxidação à sulfona , tioesterificação e sulfenilação pelo emprego de NaH/MeS02SMe em DMSO. A obtenção do α - benzil - α - metilsulfonil - α - metiltio - tioacetato de etila (Ivc) foi efetuada a partir de ácido α-cloro acético através de reações de sulfenilação por substituição oxidação à sulfona tioesterificação alquilação com brometo de benzila e NaH em DMSO e, finalmente, a sulfenilação que só foi possível com o emprego de N-metiltioftalimida. A síntese de α-metilsulfonil-α-metiltio-propionato de etila (V) foi efetuada a partir do α-metilsulfonil malonato VIIa pelo eemprego do método de descarbetoxilação sulfenilativa usando 1,4 diazabiciclo [2,2,2] octano (DABCO) em tolueno sob refluxo e MeSO2SMe. Os compostos VIIa,b e c foram preparados a partir dos malonatos de dietila alquil - substituidos, seguido de sulfenilação e oxidação à sulfona. É de interesse a inédita reação de α - metilsulfonil fenilmalonato de dietila (VIIb), com DABCO em benzeno sob refluxo e MeSO2SMe, que conduziu à dessulfonilação sulfenilativa fornecendo o α - metiltio - fenilmalonato de dietila. É apresentada uma discussão mecanística tanto sobre descarbetoxilação, como sobre dessulfonilação sulfenilativas. A síntese de α,α-dimetiltio-ésteres VIa-c foi efetuada pela reação de sulfenilação com descarboxilação dos mono-ácidos malônicos correspondentes. O acompanhamento da descarboxilação e experimentos de deuteração permitiram esclarecer a sequência dos passos reacionais nestas novas reações. Cabe ressaltar que são compostos ainda não descritos na literatura os precursores IVa, IVb, IVc, V e Vib e 11 intermediários envolvidos nas reações efetuadas. Os resultados apresentados neste trabalho, além de importância sintética, trazem uma contribuição para a Química de Compostos Orgânicos de Enxofre.
This work presents: 1) Two literature reviews, one about the synthesis of α-keto thioesters and esters and the other on the decomposition of sulfenylated sulfoxides and sulfones; 2) Previous investigations indicating the viability of thermal decomposition and the relative stability of the dithioderivatives of different oxidation states Ia-e,which were obtained from the α-keto thioester; 3) The study of synthesis of α-keto thioesters II and esters III precursors, which are the following: α-methylsulfonyl-α-methylthio-thioesters IVa-c and -ester V, and α, α - dimethylthio esters VIa-c; 4) Thermal decomposition of the synthesized α - methylsulfonyl- α -methylthio- thioesters Iva,b e c and ester V, to the corresponding α-keto thioesters and α-keto ester, through the method developed by Wladislaw et al., with the suggestion of the mechanism. α-Methylsulfonyl-α-methylthio ethyl thiopropionate (Ivb) was synthesized from α-chloro-propionic acid in four steps: sulfenylative substitution, oxidation to sulfone, thioesterification and sulfenylation using NaH/MeSO2SMe in DMSO. α-Benzyl-α-methylsulfonyl-α-methylthio ethyl thioacetate (,i>Ivc) was obtained from α-chloro acetic acid through the following steps: sulfenylative substitution, oxidation to sulfone, thioesterification, alkylation with benzylbromide and NaH in DMSO, and finally, the sulfenylation which was successful only with the use of N-methylthiophtalimide. α-Methylsulfonyl-α-methylthio ethyl propionate (V) was synthesized through the sulfenylative decarbethoxylation of α methylsulfonyl diethyl malonate VIIa employing DABCO (1,4-diazabicyclo [2.2.2.]octane), in refluxing toluene, and MeSO2Sme. The compounds VIIa,b e c were obtained by the alkylation of malonates, followed by sulfenylation and oxidation to sulfones. An interesting and novel reaction, the sulfenylative desulfonylation, was observed when α-methylsulfonyl phenyldiethyl malonate (VIIb) was treated with DABCO, in refluxing benzene and MeSO2SMe, which led to the α-methylthio diethyl malonate. A mechanistic discussion about the sulfenylative decarbethoxylation and sulfenylative desulfonylation is presented. α, α-dimethylthio esters VIa-c were synthesized by sulfenylation and decarboxylation of the corresponding malonic half-esters. The sequence of the steps of this new reaction could be determined by deuteration experiments and by following the evolution of CO2. The precursors IV, IVb, IVc, V e Vib and 11 intermediates were unknown compounds. This work, besides the synthetical importance, presents some contribution to the Organosulfur Chemistry.
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Books on the topic "Malonates"

1

Serignan, Philippe. Synthesis of polyfluoroalkyl malonates. Birmingham: University of Birmingham, 1996.

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Edmond, T. Sausu, Malonas, Tolai, lessons in succesful transmigration: Agro-economic study of three transmigration centers in the Sulawesi Tengah Province. Jakarta: Indonesia-Orstom Transmigration Project PTA-44, 1989.

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PT, Planars, ed. Studi integrasi tata ruang pemukiman transmigrasi: Dengan studi kasus 5 lokasi, Sabulussalam, Ipuh Sebelat, Kurau, Malonas, Nabire : laporan akhir. Jakarta: Planars, 1989.

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Book chapters on the topic "Malonates"

1

Meldrum, Alicia, Keith J. Page, Barry J. Everitt, and Stephen B. Dunnett. "Malonate." In Mitochondrial Inhibitors and Neurodegenerative Disorders, 201–17. Totowa, NJ: Humana Press, 2000. http://dx.doi.org/10.1007/978-1-59259-692-8_14.

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Schomburg, Dietmar, Margit Salzmann, and Dörte Stephan. "Malonate-semialdehyde dehydrogenase." In Enzyme Handbook, 83–85. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-58051-2_13.

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Schomburg, Dietmar, and Margit Salzmann. "Malonate-semialdehyde dehydratase." In Enzyme Handbook 1, 689–91. Berlin, Heidelberg: Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-86605-0_152.

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Schomburg, Dietmar, and Dörte Stephan. "Malonate CoA-transferase." In Enzyme Handbook, 1049–51. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-59025-2_198.

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Schomburg, Dietmar, Margit Salzmann, and Dörte Stephan. "Malonate-semialdehyde dehydrogenase (acetylating)." In Enzyme Handbook, 95–97. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-58051-2_16.

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Wohlfarth, Ch. "Viscosity of diethyl malonate." In Supplement to IV/18, 469. Berlin, Heidelberg: Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-75486-2_258.

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Wohlfarth, Christian. "Viscosity of dimethyl malonate." In Viscosity of Pure Organic Liquids and Binary Liquid Mixtures, 162. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49218-5_142.

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Wohlfarth, Christian. "Viscosity of diethyl malonate." In Viscosity of Pure Organic Liquids and Binary Liquid Mixtures, 287. Berlin, Heidelberg: Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-49218-5_261.

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Schomburg, Dietmar, and Ida Schomburg. "biotin-independent malonate decarboxylase 4.1.1.88." In Class 3.4–6 Hydrolases, Lyases, Isomerases, Ligases, 406–11. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36260-6_30.

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Schomburg, Dietmar, and Ida Schomburg. "biotin-dependent malonate decarboxylase 4.1.1.89." In Class 3.4–6 Hydrolases, Lyases, Isomerases, Ligases, 412–15. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36260-6_31.

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Conference papers on the topic "Malonates"

1

Lemos, Reinier, Luis Almagro, Blanca Tolón Murgía, and Margarita Suárez. "Amphipathic malonates as potential antiviral agents." In 7th International Electronic Conference on Medicinal Chemistry. Basel, Switzerland: MDPI, 2021. http://dx.doi.org/10.3390/ecmc2021-11392.

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Peterle, Marcos M., Marcelo V. Marques, and Marcus M. Sá. "α-Hydroxylation of malonates under mild reaction conditions." In 15th Brazilian Meeting on Organic Synthesis. São Paulo: Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_2013820152632.

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Xiong, He-Hua, Yong-Li Duan, Shuang Jia, Ding-Ling Shi, Zhi-Min Li, and Qi-Dong Tang. "Synthesis of Diethyl 2-(2-chloronicotinoyl)malonate." In 2017 2nd International Conference on Biological Sciences and Technology (BST 2017). Paris, France: Atlantis Press, 2018. http://dx.doi.org/10.2991/bst-17.2018.39.

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Kedra-Krolik, Karolina, Tajana Begovic, Marzena Prus, Danijel Namiesnik, Karolina Szymanek, Wojciech Piasecki, and Piotr Zarzycki. "Electrochemical Evidence of Malonate Specific Sorption to Hematite." In Goldschmidt2020. Geochemical Society, 2020. http://dx.doi.org/10.46427/gold2020.1265.

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Kedra-Krolik, Karolina, Marzena Prus, Danijel Namiesnik, Tajana Begović, and Piotr Zarzycki. "Electrokinetic and potentiometric insight into malonate arrangement at hematite/water interface." In Goldschmidt2021. France: European Association of Geochemistry, 2021. http://dx.doi.org/10.7185/gold2021.8151.

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Martin, I. R., F. Lahoz, V. Lavin, and M. Hernandez-Molina. "Optical properties of Eu3+in malonate crystals to monitor a structural phase transition." In 19th Congress of the International Commission for Optics: Optics for the Quality of Life, edited by Giancarlo C. Righini and Anna Consortini. SPIE, 2003. http://dx.doi.org/10.1117/12.525861.

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Kurukunda, Santhosh, Salvatore Cerruto, Salvatore Graziani, Carlo Trigona, Giovanna Di Pasquale, Antonino Pollicino, Kaija Põhako-Esko, and Alvo Aabloo. "Comparison of Bacterial Cellulose Deformation Sensors Based on Choline Malonate and EMIM-BF4 Ionic Liquids." In Eurosensors 2023. Basel Switzerland: MDPI, 2024. http://dx.doi.org/10.3390/proceedings2024097085.

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Seijas, Julio, M. Pilar Vázquez-Tato, and José Crecente-Campo. "Synthesis of 4-phenylcoumarin from 2-hydroxybenzophenone imine and diethyl malonate by microwave assisted Knoevenagel condensation." In The 13th International Electronic Conference on Synthetic Organic Chemistry. Basel, Switzerland: MDPI, 2009. http://dx.doi.org/10.3390/ecsoc-13-00161.

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Iwai, Taro, Shin Oguro, Iku Ohta, Atsushi Hotta, and Ryo Ohmura. "Thermophysical Properties of a Promising Material for Thermal Energy Storage Synthesized by Tetrabutylphosphonium Malonate and Water." In 2022 IEEE Asia-Pacific Conference on Computer Science and Data Engineering (CSDE). IEEE, 2022. http://dx.doi.org/10.1109/csde56538.2022.10089296.

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Reports on the topic "Malonates"

1

Cataldo, D. A., M. W. Ligotke, S. D. Harvey, R. J. Fellows, Shu-mei W. Li, P. Van Voris, and R. S. Wentsel. Acute environmental toxicity and persistence of DEM, a chemical agent simulant: Diethyl malonate. [Diethyl malonate]. Office of Scientific and Technical Information (OSTI), May 1990. http://dx.doi.org/10.2172/6109186.

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