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Journal articles on the topic 'Malonic dialdehyde (MDA)'

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1

Hasan, A. M. M. Almansoub, and Almansoob Rowdh. "The Role of Alleviate Oxidative Stress of Oxytocin in The Neurodegenerative Disorders." International Journal of Innovative Science and Research Technology Special Issue, no. 2nd ICTSA-2022 (2023): 1–3. https://doi.org/10.5281/zenodo.7752543.

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Neurodegenerative diseases are characterized by progressive damage in neural cells and neuronal loss; bearing in mind the relevance of oxidative stress in neurodegenerative diseases, including Alzheimer's and Parkinson's diseases, and the antioxidant properties of oxytocin, which we previously demonstrated, we studied the effects of oxytocin administration 5µM oxytocin for 24h, on enzymatic activities of superoxide dismutase (SOD) and malonic dialdehyde (MDA) level in the Neuro2a cells (N2a cell lines ) which treated by 250 µM hydrogen peroxide( H2O2 ) for 24h. In these cel
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2

Smirnova, L. P., N. V. Krotenko, E. V. Grishko, N. M. Krotenko, V. M. Alifirova, and S. A. Ivanova. "Antioxidant system state in patients with multiple sclerosis current in therapy." Biomeditsinskaya Khimiya 57, no. 6 (2011): 661–70. http://dx.doi.org/10.18097/pbmc20115706661.

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Activity of erytrocyte glutationperoxidase (GP), glutationreductase (GR), glutationtransferase (GT), glucose-6-phosphatdehydrogenase (G6PDH), catalase and superoxiddysmutase (SOD), and also, the level of malonic dialdehyde (MDA) and total antioxidant activity of blood serum were studied in patients with different types of multiple sclerosis. Investigation of peripherical blood was carried out on first day of treatment and after standard therapy of copaxone. All MS patients had high level of MDA and activity of GP in erythrocytes in comparison with a control group. Other antioxidant enzymes of
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3

Tishenin, R. S., T. A. Filonenko, A. V. Dreval, and T. S. Kamynina. "Lipid peroxidation and a-tocopherol in patients with diffuse toxic goiter." Problems of Endocrinology 46, no. 6 (2000): 26–28. http://dx.doi.org/10.14341/probl11880.

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Plasma and erythrocyte concentrations of lipid acyl hydroperoxides, malonic dialdehyde (MDA), and a-tocopherol were measured in 45patients with diffuse toxic goiter (DTG) before and after thyrostatic therapy and in 26 of these patients 3—6 months after subtotal resection of the thyroid in a state of euthyrosis. The initial link in lipid peroxidation (LPO) was activated in erythrocytes and plasma in hyperthyrosis, while toxic LPO product MDA accumulated only in the plasma. The level of one ofpotent antioxidants a-tocopherol was decreased at all stages of examination in erythrocytes, while in th
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4

Tatzber, Franz, Edith Pursch, Ulrike Resch, et al. "Cultivation and Immortalization of Human B-Cells Producing a Human Monoclonal IgM Antibody Binding to MDA-LDL: Further Evidence for Formation of Atherogenic MDA-LDL Adducts in HumansIn Vivo." Oxidative Medicine and Cellular Longevity 2017 (2017): 1–7. http://dx.doi.org/10.1155/2017/6047142.

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Oxidatively modified low-density lipoprotein (oLDL) is firmly believed to play an important role in the initiation and development of atherosclerosis, and malonic dialdehyde (MDA) is one of the major lipid peroxidation breakdown products involved in this process. In recent decades, antibodies against MDA-LDL have been detected in human and animal sera. In our study, human B-cells from the peripheral blood of a healthy female donor were fused with the SP2/0 mouse myeloma cell line. Antibody-producing hybridomas were detected by MDA-LDL-IgG/IgM enzyme-linked immunosorbent assays (ELISA) and Cu++
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5

Tolstoy, V., A. Lytvynets та I. Langrová. "Increasing antioxidant protection during mebendazole and AKβ vitamin complex treatment of experimental trichinellosis in rats". Helminthologia 46, № 3 (2009): 145–50. http://dx.doi.org/10.2478/s11687-009-0028-5.

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AbstractTo enhance the effect of treatment method of Trichinellosis with mebendazole, lipid peroxidation processes (LPP) in blood of Wistar rats experimentally infected with Trichinella spiralis were investigated. In accordance with health condition of infected rats treated with mebendazole and combination of mebendazole and AKβ vitamin complex, dynamics of the main values of the LPP (such as: activity of superoxide dismutase (SOD) and catalase (CAT) in erythrocytes and malonic dialdehyde (MDA) concentration in blood serum) were analyzed. It was concluded that mebendazole amplifies the LPP in
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6

Atamaniuk, N. P., L. P. Derevianko, V. V. Tal'ko, et al. "Radiologically-induced changes of oxidative processes in female rats blood with the use of different doses and irradiation types." Nuclear Physics and Atomic Energy 12, no. 2 (2011): 173–79. https://doi.org/10.15407/jnpae2011.02.173.

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Influence of single total body irradiation and local head irradiation of female rats in doses 2.0 and 6.0 Gy on malonic dialdehyde (MDA) concentration, on catalase and on superoxiddismutase (SOD) activities in blood was studied in dynamics (7, 14, 30, 90 days after irradiation). Irradiation was fulfilled on X-ray-installation "РУМ-17" (Russia), the power of exposition dose 2.09 · 10-4 C/(kg · sec). Indices changes, which characterize the state of prooxidantive-antioxidantive equilibrium were noted both in the total and local irradiation of the head. Increase of MDA concentration in the blood s
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7

Palmina, Nadezhda P., Elena L. Maltseva, Tatyana E. Chasovskaya, et al. "Effects of Different Phases of Cigarette Smoke on Lipid Peroxidation and Membrane Structure in Liposomes." Australian Journal of Chemistry 67, no. 6 (2014): 858. http://dx.doi.org/10.1071/ch13663.

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This paper discloses for the first time the effects of the gas phase (GP) and the tar of cigarette smoke on lipid peroxidation (LPO) and on the structure of different lipid regions in liposomes. The LPO development was analysed in terms of the total unsaturation of lipids (double-bond, DB, content) and the formation of dienic conjugates (DC), ketodienes (KD), and malonic dialdehyde (MDA). As expected, the exposure of liposomes to either the GP or the tar led to a significant decrease in the DB content. However, the formation of oxidation products revealed different dynamics: MDA generation was
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8

ISMOILOV, K. I., M. S. KHUSENOVA, A. M. SABUROVA, and KH R. NASYRDZHОNOVA. "ANTIOXIDANT STATUS AND LIPID PEROXIDATION IN HEREDITARY HEMOLYTIC ANEMIA IN CHILDREN." AVICENNA BULLETIN 27, no. 2 (2025): 340–49. https://doi.org/10.25005/2074-0581-2025-27-2-340-349.

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Objective: To examine the parameters of lipid peroxidation (LPO) and antioxidant system (AOS) in children with hereditary hemolytic anemia (HHA). Methods: A study was conducted in the Pediatric Hematology Department of the National Medical Center "Shifobakhsh" in Dushanbe, Tajikistan, involving 60 patients diagnosed with HHA. Based on the severity of HHA, the patients were divided into three groups: 20 children (33%) with mild HHA, 23 children (39%) with moderate HHA, and 17 children (28%) with severe HHA. A control group was established, comprising 20 healthy children matched by gender and ag
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9

Евсеенко, Д. А., З. А. Дундаров, Н. В. Чуешова, И. А. Чешик, В. М. Щемелев, and Е. А. Щурова. "Some Indices of Antioxidant Status before Treatment of Patients with Liver Cirrhosis and Acute Blood Loss." Хирургия. Восточная Европа 13, no. 3 (2024): 381–89. http://dx.doi.org/10.34883/pi.2024.

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Введение. Состояние антиоксидантного статуса является неотъемлемым составляющим в регуляции обменных процессов в органах и тканях. При его низких емкостных резервах, обусловленных различными патологическими состояниями, наблюдается развитие окислительного стресса с последующим формированием синдрома полиорганной недостаточности, что является основанием для разработки мер по патогенетически оправданному лечению пациентов с циррозом печени и острой кровопотерей. Цель. Изучить некоторые показатели антиоксидантного статуса до лечения пациентов с циррозом печени и острой кровопотерей. Материалы и м
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10

Mykytenko, A. O. "INFLUENCE OF SYSTEMIC INFLAMMATORY RESPONSE SYNDROME ON THE DEVELOPMENT OF OXIDATIVE STRESS DURING SIMULATION OF CHRONIC ALCOHOL INTOXICATION IN RATS." Biotechnologia Acta 15, no. 2 (2022): 62–63. http://dx.doi.org/10.15407/biotech15.02.062.

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The aim of our study was to analyze changes in the development of oxidative stress in the liver of rats with chronic alcohol intoxication against the background of systemic inflammatory response syndrome based on the study of catalase and superoxide dismutase activity, concentration of malonic dialdehyde, oxidatively modified proteins and sulfide anion and superoxide anion production. Methods. Experimental studies were performed on 12 male Wistar rats weighing 180‒220 g. Animals were divided into two groups: 1 ‒ control and 2 ‒ animals, on which we simulated alcoholic hepatitis and SIRS. The a
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11

Shestakova, S. A., M. L. Stepanyan, V. A. Titova, and N. V. Boikova. "Functional activity of platelets in the early periods of angiopathy formation in rats with alloxane diabetes." Problems of Endocrinology 42, no. 4 (1996): 34–37. http://dx.doi.org/10.14341/probl12074.

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Functional and metabolic activity of platelets and anti-aggregation activity of aortic wall, as well as the specific features in the structure of renal glomeruli were studied in rats at the early stages of alloxan diabetes development. A decrease of platelet disaggregation, an increase in the levels of malonic dialdehyde (MDA) in nonactivated platelets, and an expressed increase of MDA production by thrombin-activated platelets were observed in animals with 15-day diabetes mellitus. A depression of the anti-aggregation activity of the aorta was observed in the same period. In the renal glomeru
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12

Li, Yingshun, and Yingxue Li. "Evaluate the effect of exercise core strength training on antioxidant enzyme activity in women from a biomechanical perspective." Molecular & Cellular Biomechanics 21, no. 3 (2024): 232. http://dx.doi.org/10.62617/mcb232.

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At present, the incidence rate of chronic diseases is increasing year by year. A variety of antioxidant enzymes in the human body, such as Superoxide Dismutase (SOD), Nitric Oxide Synthase (NOS), Glutathione Peroxidase (GSH Px), Malonic Dialdehyde (MDA) and Catalase (CAT), help to inhibit the generation of oxygen free radicals and play a certain role in preventing the occurrence of chronic diseases. The research on the activity of antioxidant enzymes and the delivery of antioxidant drugs has gradually become the focus of relevant scholars. The physical quality of women is lower than that of me
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13

Kletikov, Sergey S., Mariya V. Tesakova, Vladimir I. Parfenyuk, and Vladislav R. Kulagin. "ESTIMATION OF ANTIOXIDANT PROPERTIES OF 5,10,15,20-TETRAKIS(4-HYDROXYPENYL)PORPHYRINE BASED ON ELECTROCHEMICAL AND BIOLOGICAL RESEARCHES." IZVESTIYA VYSSHIKH UCHEBNYKH ZAVEDENII KHIMIYA KHIMICHESKAYA TEKHNOLOGIYA 62, no. 3 (2019): 57–63. http://dx.doi.org/10.6060/ivkkt.20196203.5869.

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The antioxidant activity of 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin was established by a test reaction of interaction with free-radical 1,1-diphenyl-2-picrylhydrazyl (DPPH). A cyclic voltammetry method was used to research the interaction of porphyrin and DPPH. According to the results of the completed research, it was established that H2T(4-OHPh) P has the highest antioxidant activity among all the porphyrins compounds studied by us. The results of the electrochemical experiment served as a basis for testing antioxidant qualities of porphyrin on living creatures – chickens of the “Mosco
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14

Liu, Chi-Feng, Chia-Hsien Lin, Chin-Fa Chen, Tian-Chyuan Huang, and Song-Chow Lin. "Antioxidative Effects of Tetramethylpyrazine on Acute Ethanol-Induced Lipid Peroxidation." American Journal of Chinese Medicine 33, no. 06 (2005): 981–88. http://dx.doi.org/10.1142/s0192415x05003570.

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Acute p.o. administration of 99.5% ethanol (0.1 ml) to fasted mice produced heart toxicity. Pretreatment with p.o. administration of tetramethylpyrazine (TMP) could prevent such toxicity effectively and dose-dependently. The maximal antioxidative effect against 99.5% ethanol-induced heart toxicity could be observed at 1 hour after TMP administration. In order to further investigate the heart protective mechanism of TMP, both lipid peroxidation level in vivo and superoxide scavenging activity were conducted. TMP exhibited a dose-dependently anti-lipid peroxidation effect in mice heart homogenat
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15

Liu, Chi-Feng, Chia-Hsien Lin, Chun-Ching Lin, Yun-Ho Lin, Chin-Fa Chen, and Song-Chow Lin. "Protective Effect of Propolis Ethanol Extract on Ethanol-Induced Renal Toxicity: Anin VivoStudy." American Journal of Chinese Medicine 33, no. 05 (2005): 779–86. http://dx.doi.org/10.1142/s0192415x05003363.

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Acute p.o. administration of absolute ethanol (10 ml/kg) to fasted mice would produce extensive renal failure. Pretreatment with p.o. administration of propolis ethanol extract (PEE) could prevent such renal failure effectively and dose dependently. This renal protective effect of PEE may be contributed, at least in part, to its antioxidative activity. The maximal antioxidative effect against absolute ethanol (AE)-induced renal failure could be observed 1 hour after PEE administration. In order to further investigate the renal protective mechanism of PEE, lipid peroxidation and superoxide scav
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16

Melnikova, Nina, Olga Vorobyova, Alyona Balakireva, et al. "The New Pharmaceutical Compositions of Zinc Oxide Nanoparticles and Triterpenoids for the Burn Treatment." Pharmaceuticals 13, no. 9 (2020): 207. http://dx.doi.org/10.3390/ph13090207.

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We studied oleogels containing zinc oxide nanoparticles (ZnO NPs) and lupane triterpenoids in sunflower oil for the treatment of burns. The modification of ZnO was carried out by treatment with alcohol solutions of betulin, betulonic acid, betulin diacetate and betulin diphosphate. The properties of modified ZnO NPs were studied by powder XRD (average sizes of 10–20 nm), FTIR (νZnO 450 cm−1), UV–vis (345–360 nm), and blue–violet emission (380–420 nm). The identification and assay of modified ZnO NPs and triterpenoids were estimated. The treatment by oleogels of deep II-degree burns was studied
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17

Salchak, S. M., Ya G. Razuvaeva, A. A. Toropova, and K. D. Arakchaa. "Morphofunctional estimation of the gastroprotective activity of the Ferulopsis hystrix dry extract in neurogenic ulcer." Experimental and Clinical Gastroenterology, no. 3 (June 22, 2020): 71–75. http://dx.doi.org/10.31146/1682-8658-ecg-175-3-71-75.

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The purpose of the research: morphofunctional estimation of the gastroprotective activity of the dry extract from the roots and rhizomes of Ferulopsis hystrix in neurogenic ulcer.Materials and methods: The studies were carried out on white Wistar rats. The neurogenic ulcer was simulated by 24-hour immobilization of the animals. The gastroprotective effect of Ferulopsis hystrix was estimated taking into account the Pauls’ index which was calculated for bleedings, erosions and strip-like ulcers as well as taking into account the morphometric indices (the depth of erosions) of the stomach mucosa.
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18

SEKEDE ET AL, Kodjovi Dovi. "In vitro antioxidant, anti-inflammatory and ex vivo nephroprotective activities of Chenopodium ambrosioides." International Journal of Pharmaceutical, Physico-chemical and Nutritional Analysis 1, no. 2 (2023): 9–15. http://dx.doi.org/10.61585/ucad-ijppna-v1i203.

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Chenopodium ambrosioides is a medicinal plant used in Togo to treat nephropathy and other diseases. The present study was undertaken to evaluate the in vitro antioxidant and anti-inflammatory capacity and the ex vivo nephroprotective capacity of Chenopodium ambrosioides extract. Antioxidant potential was determined in vitro by 2,2-Diphenyl-1-picrylhydrazyl (DPPH) scavenging, total antioxidant capacity and reducing power tests. Egg albumin denaturation and membrane stabilization tests were carried out to assess its anti-inflammatory effect. The ex vivo nephroprotective activity of the extract w
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M.S., Bobrova, Holodaieva O.A., and Vorona S.O. "RESEARCH OF PRODUCTION OF PROOXIDANTS IN THE TISSUES OF GRAINS OF ZEA MAYS L. DIFFERENT IN THE LEVEL OF RESISTANCE TO DISEASES OF CULTIVARS." Scientific Bulletin of Natural Sciences (Biological Sciences), no. 31 (December 20, 2021): 15–22. http://dx.doi.org/10.32999/ksu2524-0838/2021-31-2.

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Reactive Oxygenspecies (ROS) cause free radical peroxidation of macromolecules (FRPO). The formation of malonic dialdehyde (MDA) is the marker of FRPO, and the consequences of changes in prooxidant-antioxidant system (PAS) are evidenced by changes in the activity of the enzyme cytochrome oxidase. The study of the role of ROS in anti-infective protection of animals, oxidative explosion processes, mechanisms of aging and apoptosis has opened up the prospects for the search for analogues in the plant world. Quantitative determination of PO and FRPO products was carried out on grains of Zea mays L
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Pesnya, D. S., A. V. Romanovsky, Y. S. Klimova, R. A. Fedorov, and E. S. Ivanova. "Effect of sodium chloride on oxidative stress biomarkers of the freshwater bivalve Anodonta cygnea." Regulatory Mechanisms in Biosystems 9, no. 2 (2018): 135–40. http://dx.doi.org/10.15421/021820.

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For the first time a study was conducted of the effects of the change in the concentration of sodium chloride in water on the biomarkers of oxidative stress (enzymes: catalase (CAT), glutathione reductase (GR), glutathione-S-transferase (GST), and the levels of reduced glutathione (GSH), and a marker of peroxidation lipids (LPO) – malonic dialdehyde (MDA)) in the gills of the freshwater mollusc Anodonta cygnea. Adult specimens of A. cygnea of both sexes with a shell length of 70–100 mm were selected for the study, a total of 36 individuals. The molluscs were collected in one of the bays on the
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Zinnurova, A. B., K. P. Vorobyev, O. V. Bakina, et al. "In vitro biochemical features of cold plasma application in MCF-7 experimental breast cancer cells." Siberian journal of oncology 23, no. 6 (2025): 89–96. https://doi.org/10.21294/1814-4861-2024-23-6-89-96.

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Introduction. Low-temperature plasma is currently used in medicine, including cancer therapy. Plasma-activated biological solutions have already been proposed as potential reagents for cancer treatment. However, the biological effects in cells induced by exposure to cold plasma still remain unexplored. Investigation of the molecular mechanisms of the effects of cold plasma on cells is of great clinical importance for its clinical application. the aim of the present study was to evaluate the effect of cold plasma exposure on apoptosis, catalase activity, and malonic dialdehyde content in MCF-7
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22

Tsukanov, V. V., O. V. Smirnova, E. V. Kasparov, A. A. Sinyakov, A. V. Vasyutin, and Yu L. Tonkikh. "Changes in the indices of prooxidant and antioxidant systems in blood plasma in men with atrophic gastritis and gastric cancer." Terapevticheskii arkhiv 90, no. 2 (2018): 24–27. http://dx.doi.org/10.26442/terarkh201890224-27.

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Aim. To study changes in the indices of prooxidant and antioxidant systems in plasma in men with atrophic gastritis and gastric cancer. Materials and methods. The study included 60 healthy men, 42 patients with atrophic gastritis and 50 men, nicardipine patients with gastric cancer stage II according to TNM. All patients underwent serological diagnosis of diffuse atrophic gastritis (definition of pepsinogens and gastrin-17) and Helicobacter pylori infection. The diagnosis of "atrophic gastritis" was verified by morphological examination of biopsy specimens obtained during fibroesophagogastrodu
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Kuznietsova, Halyna M., Maryna S. Yena, Iryna P. Kotlyar, Olexandr V. Ogloblya, and Volodymyr K. Rybalchenko. "Anti-Inflammatory Effects of Protein Kinase Inhibitor Pyrrol Derivate." Scientific World Journal 2016 (2016): 1–8. http://dx.doi.org/10.1155/2016/2145753.

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In our previous studies we showed antitumor and anti-inflammatory activities of protein kinases inhibitor pyrrol derivate 1-(4-Cl-benzyl)-3-Cl-4-(CF3-fenylamino)-1H-pyrrol-2,5-dione (MI-1) on rat colon cancer model. Therefore anti-inflammatory effect of MI-1 on rat acetic acid induced ulcerative colitis (UC) model was aimed to be discovered. The anti-inflammatory effects of MI-1 (2.7 mg/kg daily) compared to reference drug Prednisolone (0.7 mg/kg daily) after 14-day usage were evaluated on macro- and light microscopy levels and expressed in 21-grade scale. Redox status of bowel mucosa was also
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Wang, Jian, Bo Zheng, Shu Yang, et al. "Silica-Coated Superparamagnetic Iron Oxide Nanoparticles Ameliorate Leukoaraiosis-Triggered Oxidative Stress via Targeting of Nrf2 to Activate IRS-1/Akt Signals." Journal of Biomedical Nanotechnology 19, no. 11 (2023): 1956–62. http://dx.doi.org/10.1166/jbn.2023.3708.

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This study mainly explored the amelioratory effect of silica-coated superparamagnetic iron oxide nanoparticles (SiO4@SPIONs) on leukoaraiosis-associated cognitive dysfunction via targeting of Nrf2 and their potential mechanism. PC12 cell line was given in vitro hypoxia-reoxygenation treatment (OGD/R) and divided into normal group, model group and SiO4@SPIONs treatment group. The cell survival rate, apoptosis rate, levels of ROS (reactive oxygen species), MDA (Malondialdehyde; malonic dialdehyde; Propanedial) and anti-oxidases were monitored. Western-blotting measured the level of Akt and Nrf2.
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Казимирский, А. Н., Ж. М. Салмаси, Н. В. Хамнагдаева, С. А. Обрубов, Л. Ю. Семенова, and Г. В. Порядин. "Disorders in retinol metabolism as an important part in the pathogenesis of myopia." ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», no. 4() (December 17, 2019): 110–14. http://dx.doi.org/10.25557/0031-2991.2019.04.110-114.

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Цель исследования - определение изменений в экспрессии поверхностных рецепторов лимфоцитов, содержание малонового диальдегида и витамина А в периферической крови у пациентов с миопией по сравнению со здоровыми донорами и построение модели патогенеза. Методы. В исследовании приняли участие 38 детей с приобретенной близорукостью средней степени и отсутствием сопутствующих хронических заболеваний, 35 детей составили группу контроля. Возраст детей варьировал от 11 до 17 лет. Методом непрямой иммунофлюоресценции используя моноклональные антитела определяли количество лимфоцитов экспрессирующих CD3,
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Khripach, Ludmila V., T. D. Knyazeva, E. V. Zheleznyak, et al. "LEVELS OF H. PYLORI ANTIBODIES AND INFLAMMATORY MARKERS IN BLOOD SERUM SAMPLES OF MOSCOW RESIDENTS." Hygiene and sanitation 98, no. 12 (2019): 1437–43. http://dx.doi.org/10.18821/0016-9900-2019-98-12-1437-1443.

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Introduction. Helicobacter pylori (Hр) is considered usually as one of the factors in the development of gastritis, peptic ulcer, and gastric cancer, and at the same time as protection from asthma, diabetes type II, and obesity. This study was carried out with a goal to evaluate possible linkage between the levels of circulating anti-Hp antibodies and inflammatory markers - IL-6, IL-8 and malonic dialdehyde (MDA) - in cross-sectional study of Moscow adults. Material and Methods. Serum samples of Moscow working-aged residents (both gender, N=252) were used for evaluation of antibodies to lysate
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Tikhaze, A. K., G. G. Konovalova, M. K. Osyaeva, M. D. Smirnova, T. V. Martynyuk, and V. Z. Lankin. "Regulation of free radical processes in healthy volunteers during experimental hyperthermia and in patients with coronary artery disease during summer heat waves." Acta Biomedica Scientifica 6, no. 5 (2021): 19–29. http://dx.doi.org/10.29413/abs.2021-6.5.3.

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Background. In view of the worsening forecast for global temperature rise worldwide, it seems relevant to study the effects of abnormal heat waves on systemic regulatory processes in people with chronic diseases, in particular coronary artery disease (CAD).Aims. This study aimed to investigate the effect of hyperthermia on oxidative stress parameters in patients with various severity of CAD and in healthy subjects.Materials and methods. We studied the level of malonic dialdehyde (MDA) and the activity of Cu,Zn-containing superoxide dismutase (Cu,Zn-SOD) in healthy subjects under conditions of
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N.V., Rositska. "Effect of hydroxycinnamic acids and coumarin on protective reactions of winter wheat leaves under drought in the early phase of ontogenesis." Plant Introduction 75 (August 1, 2017): 95–101. https://doi.org/10.5281/zenodo.2326554.

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<strong>Objective </strong> &ndash; to study the effect of hydroxycinnamic acids and coumarin on physiological and biochemical processes in plants and their role in adaptation to drought. <strong>Material and methods. </strong>The effect of drought was investigated on plants of<em> Triticum aestivum</em> L. &lsquo;Poliska 90&rsquo; growing on 20, 40 and 60 % of soil moisture. The seeds were treated with an aqueous solution of hydroxycinnamic acids (cinnamic, caffeic and chlorogenic acids) and coumarin with a concentration of 10<sup>-4</sup> M. To determine the vital state of plants, the conten
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Li, Lu, Zhen Zhu, Juan Liu, et al. "Transcription Factor GmERF105 Negatively Regulates Salt Stress Tolerance in Arabidopsis thaliana." Plants 12, no. 16 (2023): 3007. http://dx.doi.org/10.3390/plants12163007.

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The Ethylene Response Factor (ERF) transcription factors form a subfamily of the AP2/ERF family that is instrumental in mediating plant responses to diverse abiotic stressors. Herein, we present the isolation and characterization of the GmERF105 gene from Williams 82 (W82), which is rapidly induced by salt, drought, and abscisic acid (ABA) treatments in soybean. The GmERF105 protein contains an AP2 domain and localizes to the nucleus. GmERF105 was selectively bound to GCC-box by gel migration experiments. Under salt stress, overexpression of GmERF105 in Arabidopsis significantly reduced seed g
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30

Bel’skaya, L. V., and E. A. Sarf. "The Use of IR Fourier Spectroscopy of Saliva for Rapid Assessment of the Level of Lipid Peroxidation Products." Biomedical Chemistry: Research and Methods 2, no. 2 (2019): e00094. http://dx.doi.org/10.18097/bmcrm00094.

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Infrared spectroscopy of saliva is an express and non-invasive method of analysis, applicable for diagnostics of various diseases and for studying metabolic processes and adaptive changes in the body. The goal of this study was to determine possibility of analyzing the products of lipid peroxidation (LPO) by using IR spectroscopy of saliva on the example of oncological diseases. The study involved 203 patients with lung cancer (n = 40), breast cancer (n = 50) and the control group (n = 113). Saliva samples were collected in the morning after overnight fast. The content of LPO products (conjuga
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31

Kushta, Anna. "METHOD OF CORRECTING NONSPECIFIC IMMUNITY IN PATIENTS WITH ORAL CANCER." Acta Balneologica 65, no. 2 (2023): 94–97. http://dx.doi.org/10.36740/abal202302105.

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Aim: To evaluate the antioxidant-prooxidant system of oral fluid, indicators of antimicrobial protection and bacterial contamination of the oral cavity in patients with cancer of the oral cavity and oropharynx at the stages of surgical treatment with topical lysozyme in the form of mucosa-adhesive phytogel. Materials and Methods: The study was performed in 38 patients (20 men and 18 women) with stage I-III oral cancer. The average age of patients was 56.5 years (from 33 to 75 years). The normal group included 10 people without changes in the mucous membrane of the oral cavity. Catalase, urease
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32

M., Bobrova, Arkushyna H., and Vorona S. "EFFECT OF HYPOTHERMIA ON THE CONTENT OF SUPEROXIDE ANION- RADICAL AND TBA-REACTIVE SUBSTANCES IN PLANT TISSUES." Scientific Bulletin of Natural Sciences (Biological Sciences), no. 30 (June 30, 2021): 22–30. http://dx.doi.org/10.32999/ksu2524-0838/2021-30-3.

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The influence of stressors of different nature changes the state of the prooxidantand antioxidant system. The first and most aggressive active form of Oxygen is the superoxidation radical, the secondary product of free radical lipid peroxidation is malonic dialdehyde (MDA).Hypothermia is a necessary phenomenon for plants of temperate latitudes, and a necessary factor in extending the shelf life of edible vegetative parts of plants. The purpose of the study: toidentify changes in the value of prooxidant activity in the tissues of edible parts of agricultural plants under the influence of change
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33

Korol, L., N. Stepanova, V. Vasylchenko, L. Snisar, L. Lebid, and M. Kolesnyk. "Plasma oxalic acid as a trigger for oxidative processes in end-stage renal disease patients." Ukrainian Journal of Nephrology and Dialysis, no. 1(69) (January 15, 2021): 46–53. http://dx.doi.org/10.31450/ukrjnd.1(69).2021.07.

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The present study aimed to evaluate the changes in oxidative stress markers according to the concentration of plasma oxalic acid (POx) in end-stage renal disease (ESRD) patients.&#x0D; Methods. We conducted a cross-sectional observational study involving 72 ESRD patients and 30 relatively healthy individuals who served as a control reference group for evaluation of POx concentration. Among ESRD patients there were 32 hemodialysis (HD) patients and 40 peritoneal dialysis (PD). POx concentration was measured spectrophotometrically using a commercially available kit (MAK315, Sigma, Spain). Maloni
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34

Saulin, Mihail Petrovich, Sergey Bolevich, Ekaterina Silina, et al. "Influence of the Local and Systemic Oxidative Stress on Periodontitis: Role of Antioxidant Therapy." Serbian Journal of Experimental and Clinical Research 19, no. 4 (2018): 365–72. http://dx.doi.org/10.2478/sjecr-2018-0078.

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Abstract This study was divided into experimental part of study which was conducted on 75 Wistar rats with the modeled periodontitis and and clinical part of research which included 106 patients with the chronic generalized periodontitis (CGP). The study established an importance of the oxidative stress (both local and systemic) in development and progress of the disease. It is found out that the saliva of rats with the modeled periodontitis there is the reliable increase in the content of total protein, alkaline phosphatase (ALP) and malonic dialdehyde (MDA) in 1.2, 2.6 and 2.8 times respecti
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35

Ceahlau, Mariana, Rodica Selevestru, Olga Tagadiuc, and Svetlana Sciuca. "Harmfulness of prooxidants in bronchopulmonary dysplasia in preterm children." Moldovan Journal of Health Sciences 10, no. 3 (2023): 3–10. http://dx.doi.org/10.52645/mjhs.2023.3.01.

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Introduction. Oxidative stress can be defined as the imbalance of the redox state of a certain system including living one (organelle, cell, organ/tissue), which excessively produces reactive oxygen and/or reactive nitrogen species (ROS/RNS) that exceed the capacity of the antioxidant defense system, which have the ability to slow down or even prevent the oxidative damage of macromolecules. Oxidative stress is a pathogenic mechanism of a large variety of diseases, including pulmonary one. Material and methods. 81 preterm born children included in the study were divided into the main group – pr
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36

Semenova, P. A., V. A. Nevzorova, N. G. Plekhova, I. N. Chernenko, E. S. Potapova, and U. S. Ivanchuk. "Markers of redox potential of blood leukocytes in acute coronary syndrome, depending on the presence of type 2 diabetes mellitus." Kardiologiia 63, no. 5 (2023): 33–39. http://dx.doi.org/10.18087/cardio.2023.5.n2389.

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Aim Evaluating the redox potential of white blood cells (WBC) in acute coronary syndrome (ACS) depending on the presence or absence of type 2 diabetes mellitus (DM2).Material and methods The study included 100 men and women aged 35 to 65 years who were managed for ACS at the Primary Vascular Department (PVD) of the Vladivostok Clinical Hospital #1. The control group consisted of 30 healthy volunteers matched with ACS patients in major anthropometric characteristics. Examinations were performed according to clinical recommendations. Blood was withdrawn for measuring cell activity of enzymes (su
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37

L., Korol, Stepanova N., Vasylchenko V., Snisar L., Lebid L., and Kolesnyk M. "Plasma oxalic acid as a trigger for oxidative processes in end-stage renal disease patients." Ukrainian Journal of Nephrology and Dialysis 1, no. 69 (2021): 46–53. https://doi.org/10.31450/ukrjnd.1(69).2021.07.

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The present study aimed to evaluate the changes in oxidative stress markers according to the concentration of plasma oxalic acid (POx) in end-stage renal disease (ESRD) patients. Methods. We conducted a cross-sectional observational study involving 72 ESRD patients and 30 relatively healthy individuals who served as a control reference group for evaluation of POx concentration. Among ESRD patients there were 32 hemodialysis (HD) patients and 40 peritoneal dialysis (PD). POx concentration was measured spectrophotometrically using a commercially available kit (MAK315, Sigma, Spain). Malonic dial
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38

Li, Ke, Xujie Ya, Xiujuan Duan, Yang Li, and Xuefeng Lin. "miRNA-19b-3p Stimulates Cardiomyocyte Apoptosis Induced by Myocardial Ischemia Reperfusion via Downregulating PTEN." Disease Markers 2021 (December 16, 2021): 1–7. http://dx.doi.org/10.1155/2021/9956666.

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Objective. To clarify the function of miRNA-19b-3p in accelerating myocardial ischemia-reperfusion injury- (MIRI-) induced cardiomyocyte apoptosis by downregulating gene of phosphate and tension homology deleted on chromsome ten (PTEN), thus influencing the progression of acute myocardial infarction. Materials and Methods. miRNA-19b-3p and PTEN levels in HCM cells undergoing hypoxia/reoxygenation (H/R) were determined. Meanwhile, activities of myocardium injury markers [lactate dehydrogenase (LDH), malondialdehyde; malonic dialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidas
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39

Li, Lin, Zheng Zhang, Hua Tian, et al. "Roles of Nitrogen Deep Placement on Grain Yield, Nitrogen Use Efficiency, and Antioxidant Enzyme Activities in Mechanical Pot-Seedling Transplanting Rice." Agronomy 10, no. 9 (2020): 1252. http://dx.doi.org/10.3390/agronomy10091252.

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Mechanical pot-seedling transplanting (PST) is an efficient transplanting method and deep nitrogen fertilization has the advantage of increasing nitrogen use efficiency. However, little information is available about the effect of PST when coupled with mechanized deep nitrogen (N) fertilization on grain yield, nitrogen use efficiency, and antioxidant enzyme activities in rice. A two-year field experiment was performed to evaluate the effect of PST coupled with deep N fertilization in both early seasons (March–July) of 2018 and 2019. All seedlings were transplanted by PST and three treatments w
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40

Razuvaeva, Yanina G., Kristina V. Markova, Anyuta A. Toropova, Nina I. Kashchenko, and Daniil N. Olennikov. "Chemical Constituents, Neuroprotective and Antioxidant Potential of Klasea centauroides Leaves." Applied Sciences 13, no. 2 (2023): 860. http://dx.doi.org/10.3390/app13020860.

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Owing to progressive aging in the population, there is an increase in patients with cognitive impairment. For the prevention of dementia, the use of plant remedies is relevant. Of particular interest is Klasea centauroides (L.) Cass. (Serratula centauroides L., Asteraceae), which has significant natural reserves, contains a wide range of biologically active substances, and is used in folk medicine to treat nervous system diseases. This study aimed to estimate the neuroprotective, energy-protective, and antioxidant effects of K. centauroides extract in cholinergic deficiency caused by long-term
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41

Smirnova, O., I. Kalashnikova, and G. Kurbatov. "MDA PHOTOMETRY IN SOLUTIONS: COMPARISON OF METHODS OF DIRECT OPTICAL DENSITY DATA AND DERIVATIVE SPECTROSCOPY." Russian Journal of Biological Physics and Chemisrty 8, no. 4 (2024): 468–76. http://dx.doi.org/10.29039/rusjbpc.2023.0648.

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In this study, we analyzed the absorption spectra of the reaction products of aqueous extracts of mouse tissues with thiobarbituric acid, with the aim to determine the concentration of malonic dialdehyde (MDA) in them. The concentration of MDA is an important part of the analysis of the redox status of tissues, which is important in the study of inflammatory reactions, for example, after various stressful effects, as well as in the study of aging. In normal practice, they calculate the concentration of MDA in a solution by its optical density at 532 nm, then these data are related with similar
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42

Aliyev, A., N. Mamedova, V. Madatova, and R. Babayeva. "The change in the intensity of products of lipid peroxidation have simultaneously enucleation and epiphysectomical animals." Bulletin of Science and Practice, no. 6 (June 14, 2017): 54–57. https://doi.org/10.5281/zenodo.808213.

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As noted in previous studies, the intensity of lipid peroxidation (LP) is dependent on the functional state of organs and tissues, the impact of such factors as the postnatal development of the body, adaptation to extreme factors — ionizing radiation, breach of the oxygen supply, poisoning, change of endocrine status of the organism, stress greatly increase the LP. Increased lipid peroxidation causes structural and functional modifications in the cell membranes, compounding pathological processes. We studied the violation of intensity of lipid peroxidation in different brain structures have ep
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43

Makarenko, О. А., V. V. Kika, and L. M. Mudrik. "IMBALANCE OF ANTIOXIDANT-PROOXIDANT SYSTEM IN RAT'S JAW BONE TISSUE UNDER LONG-TERM INTRODUCTION OF ETHANOL." Odesa National University Herald. Biology 26, no. 1(48) (2021): 105–14. http://dx.doi.org/10.18524/2077-1746.2021.1(48).232849.

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Introduction. Nowadays, it is unclear what the trigger for bone resorption under the influence of chronic alcohol consumption is. As the reactions of conversion of ethanol into acetic acid are accompanied by an increase in the production of reactive oxygen species, it can be assumed that the formation of oxidative stress with prolonged alcohol consumption occurs in bone tissue as well. Aim. Research of the effect of chronic administration of ethanol to females and males laboratory rats on indices of resorption, osteogenesis, the condition of the antioxidant-prooxidant system in bone tissue. Ma
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44

Pletnov, Vadym, Olexiy Tkachenko, Oleh Akimov, and Andrii Mykytenko. "Effect of lipopolysaccharide on the development of oxidativenitrosative stress in salivary glands and soft periodontal tissues of rats under conditions of water avoidance stress." European Journal of Clinical and Experimental Medicine 22, no. 2 (2024): 404–16. http://dx.doi.org/10.15584/ejcem.2024.2.30.

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Introduction and aim. Violation in the salivary glands will inevitably cause changes in periodontium, and periodontitis can disrupt the functioning of the salivary glands. The purpose of the work is to evaluate changes in NO-synthase and arginase activities, pro- and antioxidant balance in rat salivary glands and soft periodontal tissues during administration of bacterial lipopolysaccharide (LPS) and water avoidance stress (WAS) modeling. Material and methods. The experiment was performed on 24 rats. The animals were divided into 4 groups: control, WAS, animals injected intraperitoneally with
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45

GALEEVA, N. V., I. KH VALEEVA та YU V. FAZYLOVA. "Сorrelation between the number and aggregation capacity of platelets and the process of lipid peroxidation in patients with chronic hepatitis С". Practical medicine 20, № 1 (2022): 37–43. http://dx.doi.org/10.32000/2072-1757-2022-1-37-43.

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The purpose — to determine the role of the relationship between the number and aggregation capacity of platelets (Tr) with the process of lipid peroxidation (POL) in the natural course of chronic hepatitis C (HCV). Material and methods. 332 patients with HCV were observed, divided into three groups according to the phases of disseminated intravascular coagulation and the number of Tr: the first group — the hypercoagulation phase (Tr &gt; 330 x 109/l, n = 22); the second — the transition phase (Tr from 330 to 200 x 109/L, n = 132); the third — hypocoagulation (Tr &lt; 200 x 109/L, n = 178). The
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Popova, T. A., E. A. Muzyko, M. V. Kustova, et al. "Influence of the dense extract from herb of Primula veris L. On the oxidative stress development and the functional state of the cardiomyocytes mitochondria of rats with experimental chronic heart failure." Biomeditsinskaya Khimiya 64, no. 4 (2018): 334–43. http://dx.doi.org/10.18097/pbmc20186404334.

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Experimental chronic heart failure (CHF), caused by administration of L-isoproterenol (2.5 mg/kg twice a day intraperitoneally for 21 days), promotes uncoupling of respiration and oxidative phosphorylation. The rate of mitochondrial oxygen consumption in the metabolic state V3 by Chance in animals with CHF decreased by 53.3% (p&lt;0.05) with malate using (as an oxidation substrate feeding сomplex I of the electron transport chain (ETC)), by 70.6% (p&lt;0.05) with succinate using (сomplex II substrate) and by 63.6% (p&lt;0.05) when malate and succinate were added simultaneously. The respiratory
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Al-Omari, O. M. "STATE OF THE PROOXIDANT-ANTIOXIDANT EQUILIBRIUM IN THE PROCESS OF COMPLEX THERAPY IN PATIENTS WITH FOCAL SCLERODERMY." Dermatology and Venerology, no. 3 (2021): 22–27. http://dx.doi.org/10.33743/2308-1066-2021-3-22-27.

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Introduction. The development of oxidative stress in focal scleroderma is the basis for the use of antioxidant therapy in the treatment of this disease, in connection with which drugs of natural antioxidants are of interest. The objective was to study the effect of complex treatment on the level of oxidative stress of proteins and lipids, the state of the antioxidant defense system in focal scleroderma. Materials and research methods. The study included 78 patients with focal scleroderma. In the comparison group (n=38) treatment was prescribed according to the recommendations. In the main grou
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Pantea, Valeriana, Veaceslav Popa, Olga Tagadiuc, Lilia Andronache, and Valentin Gudumac. "Changes of oxidative stress indices and antioxidant system in the liver tissue on the administration of some coordination compound of copper, derivatives of thiosemicarbazide." Moldovan Journal of Health Sciences 29, no. 3 (2022): 7–12. http://dx.doi.org/10.52645/mjhs.2022.3.02.

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Introduction. Identification, study and testing of new remedies for treatment approaches of diseases, resulting from imbalance between oxidants and antioxidants in favor of oxidants, with potentially destructive potential and pathogenesis in liver disorders is of particular interest due to the increase in incidence and severity of these pathologies. Material and methods. The action of novel local copper coordination compounds, thiosemicarbazide derivatives - CMD-4, CMJ-33 and CMT-67, was evaluated in experiments on white rats after subcutaneous administration in two different doses (0.1 and 1.
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Logvinenko, Lidia, Nadezhda Golubkina, Irina Fedotova, et al. "Effect of Foliar Sodium Selenate and Nano Selenium Supply on Biochemical Characteristics, Essential Oil Accumulation and Mineral Composition of Artemisia annua L." Molecules 27, no. 23 (2022): 8246. http://dx.doi.org/10.3390/molecules27238246.

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Selenium (Se) biofortification of aromatic plants is a promising strategy to produce valuable functional food with high biological activity and enhanced essential oil yield. The experiment carried out in 2021 and 2022 on A. annua treated with sodium selenate or nano-Se sprayed on foliar apparatus demonstrated a significant increase in photosynthetic pigments, pectin, waxes, macro- and microelements and a decrease in malonic dialdehyde (MDA) accumulation. Contrary to literature reports, neither selenate nor nano-Se showed a beneficial effect on essential oil accumulation; the oil yield did not
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50

Belyaeva, L. E., and H. N. Pauliukevich. "The biochemical estimation of the nitric oxide system in prenatally stressed rats." Regional blood circulation and microcirculation 20, no. 3 (2021): 61–69. http://dx.doi.org/10.24884/1682-6655-2021-20-3-61-69.

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Introduction. Pregnancy development following unfavorable conditions could facilitate disorders of nitric oxide (NO) production during offspring’s postnatal life and «program» offspring’s cardiovascular diseases. Investigation of particular features and mechanisms of nitric oxide synthesis and action disorders following prenatal stress will promote expansion of considerations about pathogenesis of different cardiovascular diseases and propose new approaches to their prevention and management.The aim of the investigation is to assess the nature of nitric oxide synthesis and action in mature rat
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