Academic literature on the topic 'Mammalian toxicology'

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Journal articles on the topic "Mammalian toxicology"

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Sultatos, Lester G. "Mammalian toxicology of organophosphorus pesticides." Journal of Toxicology and Environmental Health 43, no. 3 (1994): 271–89. http://dx.doi.org/10.1080/15287399409531921.

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Lewis, Kara D., and Michael Falk. "Toxicological assessment of chondroitin sulfate oligosaccharide." Archives of Clinical Toxicology 5, no. 1 (2023): 40–51. http://dx.doi.org/10.46439/toxicology.5.023.

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Toxicology studies were conducted to evaluate the safety of chondroitin sulfate oligosaccharide (CSO) produced by the enzymatic hydrolysis of shark cartilage by a bacterial lyase. Although the safety of chondroitin sulfate, which is used as a dietary supplement, has been investigated, no safety studies have been conducted on CSO. CSO was evaluated in bacterial reverse mutagenesis, mammalian cell gene mutation using mouse lymphoma cells, in vivo mammalian erythrocyte micronucleus assays, and a ninety-day repeated dose oral toxicity study in rats. The study showed that CSO was not genotoxic. The
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Yi, Gloria, George Gao, Wayne Yi, and Long Jiang. "Toxicological assessment of anandamide." Archives of Clinical Toxicology 7, no. 1 (2025): 60–70. https://doi.org/10.46439/toxicology.7.037.

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Anandamide (AEA), an endogenous cannabinoid, has been widely studied for its physiological roles and potential therapeutic applications. However, concerns remain regarding its safety profile, particularly at higher doses. Therefore, this study aimed to investigate the acute, subchronic and genetic toxicological effects of AEA. In the bacterial reverse mutagenesis assay (Ames test), AEA did not exhibit any mutagenic activity. An in vivo mammalian erythrocyte micronucleus test showed no differences in micronucleus frequency between the negative control group and any of the AEA test groups. In ad
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Cooke, Gerard. "Toxicology of Tributyltin in Mammalian Animal Models." Immunology‚ Endocrine & Metabolic Agents in Medicinal Chemistry 6, no. 1 (2006): 63–71. http://dx.doi.org/10.2174/187152206775528815.

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Habermehl, G. "Polychlorinated Biphenyls (PCBs): Mammalian and environmental toxicology." Toxicon 27, no. 3 (1989): 399. http://dx.doi.org/10.1016/0041-0101(89)90192-x.

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Benjamin, Mark B., Pauline Gee, Steve Capaldi, and MarquéD Todd. "Mammalian stress genes: Structure-activity relationships in toxicology." Toxicology Letters 88 (October 1996): 20. http://dx.doi.org/10.1016/s0378-4274(96)80072-5.

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Namdarghanbari, Mohammad, William Wobig, Susan Krezoski, Niloofar M. Tabatabai, and David H. Petering. "Mammalian metallothionein in toxicology, cancer, and cancer chemotherapy." JBIC Journal of Biological Inorganic Chemistry 16, no. 7 (2011): 1087–101. http://dx.doi.org/10.1007/s00775-011-0823-6.

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Sarver, Jeffrey G., Jill A. Trendel, Nicole R. Bearss, et al. "Early Stage Efficacy and Toxicology Screening for Antibiotics and Enzyme Inhibitors." Journal of Biomolecular Screening 17, no. 5 (2012): 673–82. http://dx.doi.org/10.1177/1087057112438769.

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The rise in organisms resistant to existing drugs has added urgency to the search for new antimicrobial agents. Aspartate β-semialdehyde dehydrogenase (ASADH) catalyzes a critical step in an essential microbial pathway that is absent in mammals. Our laboratory is using fragment library screening to identify efficient and selective ASADH inhibitors. These preliminary agents are then tested to identify compounds with desired antimicrobial properties for further refinement. Toward this end, we have established a microplate-based, dual-assay approach using a single reagent to evaluate antibiotic a
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Guarino, A. M. "Aquatic versus mammalian toxicology: applications of the comparative approach." Environmental Health Perspectives 71 (April 1987): 17–24. http://dx.doi.org/10.1289/ehp.877117.

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Healy, Charles E., William F. Heydens, and Mark W. Naylor. "Mammalian toxicology overview and human risk assessment for sulfosulfuron." Regulatory Toxicology and Pharmacology 39, no. 3 (2004): 310–24. http://dx.doi.org/10.1016/j.yrtph.2004.02.005.

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Dissertations / Theses on the topic "Mammalian toxicology"

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McGlynn, Andrea. "Interaction of DEHA with mammalian cells." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111939.

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This project studied the biodegradation of a plasticizer, di-(2-ethylhexyl) adipate (DEHA), by two mammalian cell lines, HepG2 and WIF-B, in vitro . An MTT assay showed that DEHA had a toxic effect on both cell lines. Despite this, both hepatocyte cell lines successfully degraded the plasticizer. Metabolites were identified and quantified by gas chromatography. HepG2 cells showed minimal alcohol dehydrogense activity and this resulted in the accumulation of 2-ethylhexanol. WIF-B cells were able to breakdown the alcohol and produced 2-ethylhexanoic acid. It is important to note that an enzyme w
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Eichelberger, J. Michael. "Aflatoxin B1 Metabolism in Mammalian Pulmonary Tissue." DigitalCommons@USU, 1997. https://digitalcommons.usu.edu/etd/3981.

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Aflatoxin B1 (AFB1) is a potent dietary hepatocarcinogen and may be a lung carcinogen when inhaled. To study the relative ability of lung and liver to metabolize AFB1, a susceptible (Swiss-Webster rat) and resistant species (Syrian golden hamster) were pretreated with inducing agents in order to identify specific AFB1 metabolizing enzymes in each tissue. Analysis of AFB1-exo-epoxide (AFBO) formation, O-dealkynation assays, and protein immunoblots demonstrated that cytochrome P450 (CYP) 1A proteins were overexpressed in both the lung and liver of hamsters pretreated with 3-methylchyolanthrene (
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Radabaugh, Timothy. "Oxidation and reduction of inorganic arsenic in mammalian systems." Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/280379.

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Arsenic is a toxic metalloid and is ubiquitous in our environment. In ancient cultures it was valued as a poison and today is becoming an increasing public health problem. Chronic arsenic exposure has a broad range of toxic effects including cancer. Currently millions of people are exposed to higher levels of arsenic in their food and drinking water than is considered safe by the World Health Organization. Although arsenic metabolism is not completely understood, it is known that inorganic arsenate is reduced to arsenite which can then be methylated and excreted in the urine. It is also known
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Altshuler, Kara Denise Best 1965. "Alkylation damage in mammalian cells : an analysis of the mutagenic potential of O4-methylthymine adducts." Thesis, Massachusetts Institute of Technology, 1994. http://hdl.handle.net/1721.1/38001.

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Zheng, Wei. "Defense of mammalian body against heavy metal-induced toxicities: Sequestration by the choroid plexus and elimination via the bile." Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185389.

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Tissue sequestration and biliary elimination are two of the important mechanisms by which mammalian body defends against heavy metal insults. In rats or rabbits that had received Pb, Cd, Hg, As and ²¹⁰Po, these metal ions were sequestered in the choroid plexus at concentrations of Pb, Cd, Hg, As and Po that were 57, 33, 12, 13 and 5 times higher, respectively, than those found in the brain cortex. In addition, the concentrations of these heavy metal ions were many fold greater in the choroid plexus than in the CSF or blood. The accumulation of Pb in the choroid plexus was dose-dependent and ti
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Wall, Victor Daniel III 1963. "Expression of a mammalian cytochrome P-450 in Nicotiana tabacum for bioremediation of PCB contaminated soils." Thesis, The University of Arizona, 1991. http://hdl.handle.net/10150/277929.

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Polychlorinated biphenyls (PCBs) are resistant to metabolism in most animal species. The dog has the unique ability to metabolize and eliminate certain PCB congeners, as a result of the activity of the cytochrome P450 isozyme PBD-2. An expressible cDNA coding for PBD-2 has been introduced into the genome of tobacco plants. The PBD-2 cDNA coding sequence and a screenable marker gene coding for neomycin phosphotransferase II were introduced into tobacco leaf disks using a binary Agrobacterium tumefaciens vector system. Southern and Western blot analysis have confirmed chromosomal integration of
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Ellis, David Harold. "Silver nanoparticles: the immediate benefits of low bacterial resistance and the long-term risk of persistent stress in mammalian cells." Wright State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=wright1450827524.

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Legat, Leticiaà Nadine Alves. "Acumulação de compostos organoclorados (PCBs, DDTs e HCB) em tecido hepático de delfinídeos (Cetacea, Mammalia) do Estado do Rio de Janeiro." Universidade do Estado do Rio de Janeiro, 2011. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=2667.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>No decorrer das últimas décadas a pesquisa relacionada à contaminação de organismos marinhos por compostos organoclorados (OCs) se intensificou aliada à utilização de algumas espécies como sentinelas da qualidade ambiental quanto aos poluentes orgânicos. Dentre essas espécies, podem-se destacar os cetáceos, animais que entre outras características possuem grande longevidade, alta porcentagem lipídica em seus tecidos e são predadores de topo de cadeia trófica, tendendo assim a acumular altos níveis de OCs em seus tecidos. O presente
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Joseph-Enriquez, Brigitte. "Pharmacocinetique du fluor chez la brebis : application a la determination de la biodisponibilite du fluor d'echantillons de terre." Paris 7, 1987. http://www.theses.fr/1987PA077073.

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Pereira, de Vasconcelos Anne. "Influence d'un traitement chronique précoce au phénobarbital sur la maturation du métabolisme énergétique cérébral chez le rat au cours du développement postnatal." Nancy 1, 1987. http://www.theses.fr/1987NAN10052.

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Books on the topic "Mammalian toxicology"

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Mohamed B., Abou-Donia, ed. Mammalian Toxicology. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118683484.

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Marrs, Tim, ed. Mammalian Toxicology of Insecticides. Royal Society of Chemistry, 2012. http://dx.doi.org/10.1039/9781849733007.

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Safe, Stephen, ed. Polychlorinated Biphenyls (PCBs): Mammalian and Environmental Toxicology. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-70550-2.

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S, Safe, and Dedrick Robert L, eds. Polychlorinated biphenyls (PCBs): Mammalian and environmental toxicology. Springer-Verlag, 1987.

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1935-, Hutson D. H., and Paulson Gaylord D, eds. The mammalian metabolism of agrochemicals. J. Wiley & Sons, 1995.

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Stern, R. M. Nickel and chromium compounds and welding fumes in mammalian cell transformation bioassay in vitro. Danish Welding Institute, 1985.

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Kenaga, E. E. Commercial and experimental organic insecticides: Indexed as to their scientific, common, and trade names, code designations, uses, empirical formulas, manufactureres, mammalian toxicology, and chemical structures. Entomological Society of America, 1987.

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Abou-Donia, Mohamed. Mammalian Toxicology. Wiley & Sons, Incorporated, John, 2015.

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Abou-Donia, Mohamed. Mammalian Toxicology. Wiley, 2015.

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Abou-Donia, Mohamed. Mammalian Toxicology. Wiley & Sons, Incorporated, John, 2015.

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Book chapters on the topic "Mammalian toxicology"

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McGill, Mitchell R., C. David Williams, and Hartmut Jaeschke. "Liver Toxicology." In Mammalian Toxicology. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118683484.ch20.

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Farraj, Aimen K., Mehdi S. Hazari, and Daniel L. Costa. "Pulmonary Toxicology." In Mammalian Toxicology. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118683484.ch23.

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Gad, Shayne C. "Gastrointestinal Toxicology." In Mammalian Toxicology. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118683484.ch24.

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Martinez-Finley, Ebany J., Sam Caito, Stephanie Fretham, Pan Chen, and Michael Aschner. "Metal Toxicology." In Mammalian Toxicology. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118683484.ch8.

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Goldman, Jerome M., and and Ralph L. Cooper. "Female Reproductive Toxicology." In Mammalian Toxicology. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118683484.ch22.

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Gad, Shayne C. "Cardiovascular Toxicology and Its Evaluation." In Mammalian Toxicology. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118683484.ch19.

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Gad, Shayne C. "Alternatives toIn-VivoStudies in Toxicology." In Mammalian Toxicology. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118683484.ch2.

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Abou-Donia, Mohamed B. "Toxicology in the 21st Century." In Mammalian Toxicology. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118683484.ch28.

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Abou-Donia, Mohamed B. "General Principles." In Mammalian Toxicology. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118683484.ch1.

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Abou-Donia, Mohamed B. "Gases." In Mammalian Toxicology. John Wiley & Sons, Inc., 2015. http://dx.doi.org/10.1002/9781118683484.ch10.

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Conference papers on the topic "Mammalian toxicology"

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Žegura, B., E. Heath, A. Černoša, and M. Filipič. "Toxicity and genotoxicity studies of surface and waste water samples using a bacterial SOS/umu test and mammalian MTT and comet assay." In ENVIRONMENTAL TOXICOLOGY 2006. WIT Press, 2006. http://dx.doi.org/10.2495/etox060161.

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