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Journal articles on the topic 'Mammary cancer'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Miller, James L., Alexandra Reddy, Rebecca M. Harman, and Gerlinde R. Van de Walle. "A xenotransplantation mouse model to study physiology of the mammary gland from large mammals." PLOS ONE 19, no. 2 (2024): e0298390. http://dx.doi.org/10.1371/journal.pone.0298390.

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Although highly conserved in structure and function, many (patho)physiological processes of the mammary gland vary drastically between mammals, with mechanisms regulating these differences not well understood. Large mammals display variable lactation strategies and mammary cancer incidence, however, research into these variations is often limited to in vitro analysis due to logistical limitations. Validating a model with functional mammary xenografts from cryopreserved tissue fragments would allow for in vivo comparative analysis of mammary glands from large and/or rare mammals and would impro

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Clavijo-Maldonado, Alejandro, Enio Ferreira, Carlos Vargas-Hernández, and Fredy A. Rivera-Páez. "Canine mammary cancer." Veterinarska stanica 51, no. 4 (2020): 425–39. http://dx.doi.org/10.46419/vs.51.4.2.

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Canine mammary cancer (CMC) is one of the most common neoplasms in intact females in comparison to other species. Several risk factors have been identified, including breed, genetic predisposition, age, reproductive history, hormonal influence, diet, and body condition, in addition to previous lesions to the mammary gland, such as mammary atypical hyperplasia. An understanding of the genetic markers for the disease and a clinical approach are important for establishing a specific therapy that can allow adequate patient survivorship. Overexpression of the HER-2 gene in canines and humans is ass

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Hassan, B. B., S. M. Elshafae, W. Supsavhad, et al. "Feline Mammary Cancer." Veterinary Pathology 54, no. 1 (2016): 32–43. http://dx.doi.org/10.1177/0300985816650243.

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Feline mammary carcinoma (FMC) is similar to human breast cancer in the late age of onset, incidence, histopathologic features, biological behavior, and pattern of metastasis. Therefore, FMC has been proposed as a relevant model for aggressive human breast cancer. The goals of this study were to develop a nude mouse model of FMC tumor growth and metastasis and to measure the expression of genes responsible for lymphangiogenesis, angiogenesis, tumor progression, and lymph node metastasis in FMC tissues and cell lines. Two primary FMC tissues were injected subcutaneously, and 6 FMC cell lines we

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Gestl, Shelley A., Travis L. Leonard, Jessica L. Biddle, Michael T. Debies, and Edward J. Gunther. "Dormant Wnt-Initiated Mammary Cancer Can Participate in Reconstituting Functional Mammary Glands." Molecular and Cellular Biology 27, no. 1 (2006): 195–207. http://dx.doi.org/10.1128/mcb.01525-06.

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ABSTRACT The minimal residual disease foci that beget breast cancer relapse after a period of disease dormancy remain uncharacterized despite their enormous clinical importance. To model dormant breast cancer in vivo, we employed a transgenic mouse model in which Wnt1-initiated mammary cancer is doxycycline dependent. After regression of Wnt-dependent cancers, subclinical disease lesions were propagated in vivo using classical tissue recombination techniques. Surprisingly, outgrowths derived from dormant malignant tissue reconstituted morphologically normal ductal trees in wild-type mammary fa

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Hipp, Elizabeth, Xiaobing Fan, Sanaz A. Jansen, et al. "T2* relaxation times of intraductal murine mammary cancer, invasive mammary cancer, and normal mammary gland." Medical Physics 39, no. 3 (2012): 1309–13. http://dx.doi.org/10.1118/1.3684950.

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6

Wu, Diana, Lilian U. Thompson, and Elena M. Comelli. "MicroRNAs: A Link between Mammary Gland Development and Breast Cancer." International Journal of Molecular Sciences 23, no. 24 (2022): 15978. http://dx.doi.org/10.3390/ijms232415978.

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Breast cancer is among the most common cancers in women, second to skin cancer. Mammary gland development can influence breast cancer development in later life. Processes such as proliferation, invasion, and migration during mammary gland development can often mirror processes found in breast cancer. MicroRNAs (miRNAs), small, non-coding RNAs, can repress post-transcriptional RNA expression and can regulate up to 80% of all genes. Expression of miRNAs play a key role in mammary gland development, and aberrant expression can initiate or promote breast cancer. Here, we review the role of miRNAs

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7

Dennison, Kirsten L., Nyssa Becker Samanas, Quincy Eckert Harenda, et al. "Development and characterization of a novel rat model of estrogen-induced mammary cancer." Endocrine-Related Cancer 22, no. 2 (2015): 239–48. http://dx.doi.org/10.1530/erc-14-0539.

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The ACI rat model of 17β-estradiol (E2)-induced mammary cancer is highly relevant for use in establishing the endocrine, genetic, and environmental bases of breast cancer etiology and identifying novel agents and strategies for preventing breast cancer. E2 treatment rapidly induces mammary cancer in female ACI rats and simultaneously induces pituitary lactotroph hyperplasia and adenoma. The pituitary tumors can result in undesired morbidity, which compromises long-term studies focused on mammary cancer etiology and prevention. We have defined the genetic bases of susceptibility to E2-induced m

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8

ULLRICH, R. L., and R. J. PRESTON. "Radiation Induced Mammary Cancer." Journal of Radiation Research 32, SUPPLEMENT2 (1991): 104–9. http://dx.doi.org/10.1269/jrr.32.supplement2_104.

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9

Miller, WR. "Mammary Development and Cancer." British Journal of Cancer 78, no. 4 (1998): 558. http://dx.doi.org/10.1038/bjc.1998.538.

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10

Dabydeen, Sarah A., та Priscilla A. Furth. "Genetically engineered ERα-positive breast cancer mouse models". Endocrine-Related Cancer 21, № 3 (2014): R195—R208. http://dx.doi.org/10.1530/erc-13-0512.

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The majority of human breast cancers are estrogen receptor-positive (ER+), but this has proven challenging to model in genetically engineered mice. This review summarizes information on 21 mouse models that develop ER+ mammary cancer. Where available, information on cancer pathology and gene expression profiles is referenced to assist in understanding which histological subtype of ER+ human cancer each model might represent.ESR1,CCDN1, prolactin,TGFα,AIB1,ESPL1, andWNT1overexpression,PIK3CAgain of function, as well as loss ofP53(Trp53) orSTAT1are associated with ER+ mammary cancer. Treatment w

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11

Shimono, Yohei, Masahiro Mizuno, Jumpei Yoshida, et al. "Abstract LB078: Adipocytes promote cancer stem cell properties and metastatic progression in breast cancers." Cancer Research 85, no. 8_Supplement_2 (2025): LB078. https://doi.org/10.1158/1538-7445.am2025-lb078.

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Abstract Breast cancer is the most frequently diagnosed cancer and the leading global cause of cancer death in women. Despite advances in the diagnosis and treatment, advanced stage, metastatic breast cancers are difficult to cure. Therapeutic resistance, immune evasion, invasion, and metastasis are at least partly attributed to the behavior of cancer stem cells (CSCs), a sub-population of the cells that retain high tumorigenic capacity and have a higher ability to sustain the tumor formation. We and others have shown that in breast cancers, the self-renewal ability of cancer cells with CSC pr

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12

Sari, Yuli Permata. "Hubungan Program Pengobatan Kanker terhadap Konsep Diri Wanita dengan Carsinoma Mammae." Jurnal Keperawatan Silampari 3, no. 1 (2019): 211–20. http://dx.doi.org/10.31539/jks.v3i1.765.

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The purpose of this study was to study the relationship of treatment programs to self-concept in women with mammary carcinoma in the Polyclinic Surgery Clinic of RSUD Dr. Achmad Mochtar Bukittinggi. The design of this study uses descriptive analytic methods. The results of this study were obtained by more than half of respondents who undertook treatment programs at the poly surgical clinic of RSUD Dr. Achmad Mochtar Bukittinggi is 19 people (63.3%) and more than half obtained a low self-concept in women with carsinoma mammaes as many as 16 respondents (53, 3%) in the poly surgical clinic of Dr

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13

Betgeri, Prof Santusti. "Mammary Tumor Screening." International Journal for Research in Applied Science and Engineering Technology 13, no. 5 (2025): 5962–67. https://doi.org/10.22214/ijraset.2025.71017.

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Mammary Tumor Screening using deep learning provides an innovative approach for early breast cancer detection. In this work, a model trained on Convolutional Neural Networks (CNNs) on the Kaggle Multi Cancer dataset, consisting of 10,000 high-resolution histopathological images of benign and malignant tumors. To improve model performance and lessen overfitting, preprocessing methods like resizing, normalisation, and data augmentation are used. The CNN model .The CNN model is designed for binary classification, and itsF1-score, recall, accuracy, and precision are used to assess performance. Thi

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14

Subramani, Ramadevi, Adriana Estrada, Sheryl Rodriguez, et al. "Abstract P1-11-02: Parity reduces the risk of mammary cancer by altering the characteristics of mammary stem cells." Cancer Research 82, no. 4_Supplement (2022): P1–11–02—P1–11–02. http://dx.doi.org/10.1158/1538-7445.sabcs21-p1-11-02.

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Abstract Introduction: Parous rats treated with chemical carcinogen develop a low incidence of overt mammary cancers compared to that in carcinogen-treated nulliparous rats. Examination of the mammary glands at necropsy 12 months after carcinogen treatment revealed that a high percentage of the parous rats had preneoplastic mammary lesions. These studies demonstrate that in parous rats, initiation of mammary carcinogenesis occurs at a high efficiency, although the systemic and local environment is inadequate for promotion to overt cancers. Stem cells have been implicated as the target cells fo

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15

Mustafi, Devkumar, Abby Leinroth, Xiaobing Fan, et al. "Magnetic Resonance Angiography Shows Increased Arterial Blood Supply Associated with Murine Mammary Cancer." International Journal of Biomedical Imaging 2019 (January 17, 2019): 1–6. http://dx.doi.org/10.1155/2019/5987425.

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Breast cancer is a major cause of morbidity and mortality in Western women. Tumor neoangiogenesis, the formation of new blood vessels from pre-existing ones, may be used as a prognostic marker for cancer progression. Clinical practice uses dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) to detect cancers based on increased blood flow and capillary permeability. However, DCE-MRI requires repeated injections of contrast media. Therefore we explored the use of noninvasive time-of-flight (TOF) MR angiography for serial studies of mouse mammary glands to measure the number and size o

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16

Mazumdar, Abhijit, Jamal Hill, William Tahaney, et al. "Abstract 715: Targeting the mTOR pathway for the prevention of er-negative breast cancer." Cancer Research 82, no. 12_Supplement (2022): 715. http://dx.doi.org/10.1158/1538-7445.am2022-715.

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Abstract Background: Triple-Negative breast cancer (TNBC) is an aggressive cancer that lacks expression of the estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. These cancers have a poor prognosis and are treated predominantly with chemotherapy. Therefore, we are working to find preventive therapies for these potentially lethal cancers. Dysregulation of PI3K-mTOR pathway is commonly associated with TNBC and other ER-negative breast cancers. We hypothesized that targeting mTOR may prevent development of ER-negative breast cancers and in this study tested wh

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17

Marson, Fransiska Gratia Sonita, Palagan Senopati Sewoyo, I. Nyoman Mantik Astawa, et al. "Indonesian Newcastle Disease Virus Field Isolate Reduces c-Jun Expression in Rat Mammary Cancer Models." Media Kedokteran Hewan 36, no. 1 (2025): 13–20. https://doi.org/10.20473/mkh.v36i1.2025.13-20.

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c-Jun is often found to be overexpressed in various cancers, so this gene might be a target for cancer therapy. Newcastle disease virus (NDV) is recognized for its oncolytic properties and potential as a cancer virotherapy agent, with various mechanisms reported to trigger cancer cell death. This study aimed to assess the c-Jun expression in rat mammary cancer models. Rat mammary cancer models were categorized into two treatment groups: the control group (C) and the virotherapy group (V). Group C was administered with 0.5 cc of sterile PBS, while group V received 7 log 2 HAU per 0.5 cc of the

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18

Pulver, Emilia M., Eline van der Burg, Anne Paulien Drenth, et al. "Abstract 6624: MYC promotes lobuloalveologenesis and mammary tumorigenesis in male mice." Cancer Research 84, no. 6_Supplement (2024): 6624. http://dx.doi.org/10.1158/1538-7445.am2024-6624.

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Abstract Male breast cancer is a rare disease that is largely overlooked and clinically regarded to recapitulate female breast cancer biology. The worse overall outcome for male patients compared to females, however, underscores inadequate disease management and a sex-based divergence in disease biology. To gain more insight into male breast biology and pathology, we used mouse models of triple-negative breast cancer and 3D whole-mount confocal imaging techniques to evaluate both in vivo and ex vivo mammary gland development, tumor formation, and hormone signaling dependence. Our results show

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19

Dagher, Elie, Laura Simbault, Jérôme Abadie, Delphine Loussouarn, Mario Campone, and Frédérique Nguyen. "Identification of an immune-suppressed subtype of feline triple-negative basal-like invasive mammary carcinomas, spontaneous models of breast cancer." Tumor Biology 42, no. 1 (2020): 101042831990105. http://dx.doi.org/10.1177/1010428319901052.

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Feline invasive mammary carcinomas are characterized by their high clinical aggressiveness, rare expression of hormone receptors, and pathological resemblance to human breast cancer, especially triple-negative breast cancer (negative to estrogen receptor, progesterone receptor, and epidermal growth factor receptor type 2). Recent gene expression studies of triple-negative breast cancers have highlighted their heterogeneity and the importance of immune responses in their biology and prognostic assessment. Indeed, regulatory T cells may play a crucial role in producing an immune-suppressed micro

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20

Wiebe, John P. "Role of progesterone metabolites in mammary cancer." Journal of Dairy Research 72, S1 (2005): 51–57. http://dx.doi.org/10.1017/s0022029905001214.

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Among the species investigated, the rate of spontaneous cancers of mammary glands is highest in humans and dogs (Hamilton, 1974; Owen, 1979). In addition, spontaneous mammary tumours are known to occur in strains of mice (Webster & Muller, 1994), rats (Russo et al. 1990; Sukumar, 1995) and cats (Hamilton, 1974; Kessler & von Bombard, 1997). Although both oestrogen and progesterone are known to be involved in normal mammary development as well as in the proliferative changes that occur during the oestrous or menstrual cycle, pregnancy and lactation (Going et al. 1988), only the role of

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21

Schedin, Pepper, Jenean O’Brien, Michael Rudolph, Torsten Stein, and Virginia Borges. "Microenvironment of the Involuting Mammary Gland Mediates Mammary Cancer Progression." Journal of Mammary Gland Biology and Neoplasia 12, no. 1 (2007): 71–82. http://dx.doi.org/10.1007/s10911-007-9039-3.

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22

Saad, Eman S. A., Jacqueline S. Y. Lam, Awf A. Al-Khan, et al. "A Comparative Review of Mixed Mammary Tumors in Mammals." Journal of Mammary Gland Biology and Neoplasia 24, no. 2 (2018): 125–37. http://dx.doi.org/10.1007/s10911-018-9422-2.

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23

Ma, Zhiyuan, Dumin Yuan, Xiaoming Cheng, Biguang Tuo, Xuemei Liu, and Taolang Li. "Function of ion transporters in maintaining acid-base homeostasis of the mammary gland and the pathophysiological role in breast cancer." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 318, no. 1 (2020): R98—R111. http://dx.doi.org/10.1152/ajpregu.00202.2019.

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The incidence of breast cancer is increasing year by year, and the pathogenesis is still unclear. Studies have shown that the high metabolism of solid tumors leads to an increase in hypoxia, glycolysis, production of lactic acid and carbonic acid, and extracellular acidification; a harsh microenvironment; and ultimately to tumor cell death. Approximately 50% of locally advanced breast cancers exhibit hypoxia and/or local hypoxia, and acid-base regulatory proteins play an important role in regulating milk secretion and maintaining mammary gland physiological function. Therefore, ion transporter

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24

Bierman, Howard R., Michael R. Faith, and Morgan E. Stewart. "Digital Dermatoglyphics in Mammary Cancer." Cancer Investigation 6, no. 1 (1988): 15–27. http://dx.doi.org/10.3109/07357908809077025.

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25

Lamartiniere, C. A., J. Moore, M. Holland, and S. Barnes. "Neonatal Genistein Chemoprevents Mammary Cancer." Experimental Biology and Medicine 208, no. 1 (1995): 120–23. http://dx.doi.org/10.3181/00379727-208-43843.

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26

Prat, Aleix, and Charles M. Perou. "Mammary development meets cancer genomics." Nature Medicine 15, no. 8 (2009): 842–44. http://dx.doi.org/10.1038/nm0809-842.

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27

Fink-Retter, A., D. Gschwantler-Kaulich, C. Singer, et al. "Proteomics in mammary cancer research." Journal of Clinical Oncology 26, no. 15_suppl (2008): 22206. http://dx.doi.org/10.1200/jco.2008.26.15_suppl.22206.

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28

Schirber, Stefan, William Thomas, and John Finley. "BREAST CANCER AFTER MAMMARY AUGMENTATION." Southern Medical Journal 84, Supplement (1991): 74. http://dx.doi.org/10.1097/00007611-199109001-00270.

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29

SCHIRBER, STEFAN, WILLIAM O. THOMAS, JOHN M. FINLEY, ALLAN E. GREEN, and JOHN J. FERRARA. "Breast Cancer After Mammary Augmentation." Southern Medical Journal 86, no. 3 (1993): 263–68. http://dx.doi.org/10.1097/00007611-199303000-00001.

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30

Fink-Retter, A., D. Gschwantler-Kaulich, G. Hudelist, et al. "Proteomics in mammary cancer research." European Journal of Cancer Supplements 6, no. 7 (2008): 79. http://dx.doi.org/10.1016/s1359-6349(08)70420-8.

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31

Polk, Hiram C. "Improved understanding of mammary cancer." Cancer 57, no. 3 (1986): 411–15. http://dx.doi.org/10.1002/1097-0142(19860201)57:3<411::aid-cncr2820570303>3.0.co;2-3.

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32

Romieu-Mourez, Raphaëlle, Dong W. Kim, Sang Min Shin, et al. "Mouse Mammary Tumor Virus c-rel Transgenic Mice Develop Mammary Tumors." Molecular and Cellular Biology 23, no. 16 (2003): 5738–54. http://dx.doi.org/10.1128/mcb.23.16.5738-5754.2003.

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ABSTRACT Amplification, overexpression, or rearrangement of the c-rel gene, encoding the c-Rel NF-κB subunit, has been reported in solid and hematopoietic malignancies. For example, many primary human breast cancer tissue samples express high levels of nuclear c-Rel. While the Rev-T oncogene v-rel causes tumors in birds, the ability of c-Rel to transform in vivo has not been demonstrated. To directly test the role of c-Rel in breast tumorigenesis, mice were generated in which overexpression of mouse c-rel cDNA was driven by the hormone-responsive mouse mammary tumor virus long terminal repeat

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33

Ben-Yishay, Rakefet Ruth, Naama Herman, Vered Noy, Eyal Mor, Aiham Mansur, and Dana Ishay-Ronen. "Abstract 5847: Normal mammary epithelium of BRCA1 mutation carriers demonstrates increased susceptibility to cell plasticity." Cancer Research 82, no. 12_Supplement (2022): 5847. http://dx.doi.org/10.1158/1538-7445.am2022-5847.

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Abstract Background: Epithelial-mesenchymal transition (EMT) in breast cancer drives tumor invasion, metastasis and drug resistance. BRCA1 mutation carriers have a high risk for developing aggressive basal-like triple-negative breast cancers with EMT characteristics. It has been described that normal mammary epithelium of BRCA1-mutation carriers is comprised of aberrant luminal progenitor cell population resembling basal-like breast cancer cells. Yet, the role of BRCA1 in regulating epithelial cell plasticity in normal mammary gland remains largely obscure. Aim: Here, we used patient-derived n

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Kern, Joseph, Andrew Tilston-Lunel, Anthony Federico, et al. "Abstract P2-05-01: Inactivation of LATS1/2 drives luminal-basal plasticity to initiate basal-like mammary carcinomas." Cancer Research 82, no. 4_Supplement (2022): P2–05–01—P2–05–01. http://dx.doi.org/10.1158/1538-7445.sabcs21-p2-05-01.

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Abstract Basal-like breast cancers, an aggressive breast cancer subtype that has poor treatment options, are thought to arise from luminal mammary epithelial cells but undergo plasticity to a basal-like state upon transformation. Identifying cellular mechanisms underlying this luminal-basal plasticity will allow an improved understanding of the pathogenesis of basal-like breast cancers. The Hippo signaling pathway, an important cell fate regulator across many tissues, has been implicated in breast cancer development. Central to Hippo signaling are the tumor suppressor kinases LATS1 and LATS2 (

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Atashgaran, Vahid, Pallave Dasari, Leigh J. Hodson, Andreas Evdokiou, Simon C. Barry, and Wendy V. Ingman. "Foxp3 heterozygosity does not overtly affect mammary gland development during puberty or the oestrous cycle in mice." Reproduction, Fertility and Development 32, no. 8 (2020): 774. http://dx.doi.org/10.1071/rd19378.

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Female mice heterozygous for a genetic mutation in transcription factor forkhead box p3 (Foxp3) spontaneously develop mammary cancers; however, the underlying mechanism is not well understood. We hypothesised that increased cancer susceptibility is associated with an underlying perturbation in mammary gland development. The role of Foxp3 in mammary ductal morphogenesis was investigated in heterozygous Foxp3Sf/+ and wildtype Foxp3+/+ mice during puberty and at specific stages of the oestrous cycle. No differences in mammary ductal branching morphogenesis, terminal end bud formation or ductal el

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Nishimura, Mayumi, Kazuhiro Daino, Maki Fukuda та ін. "Development of mammary cancer in γ-irradiated F1 hybrids of susceptible Sprague-Dawley and resistant Copenhagen rats, with copy-number losses that pinpoint potential tumor suppressors". PLOS ONE 16, № 8 (2021): e0255968. http://dx.doi.org/10.1371/journal.pone.0255968.

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Copenhagen rats are highly resistant to mammary carcinogenesis, even after treatment with chemical carcinogens and hormones; most studies indicate that this is a dominant genetic trait. To test whether this trait is also dominant after radiation exposure, we characterized the susceptibility of irradiated Copenhagen rats to mammary carcinogenesis, as well as its inheritance, and identified tumor-suppressor genes that, when inactivated or mutated, may contribute to carcinogenesis. To this end, mammary cancer–susceptible Sprague-Dawley rats, resistant Copenhagen rats, and their F1 hybrids were ir

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Campbell, Caroline J., and Brian W. Booth. "The Influence of the Normal Mammary Microenvironment on Breast Cancer Cells." Cancers 15, no. 3 (2023): 576. http://dx.doi.org/10.3390/cancers15030576.

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The tumor microenvironment is recognized as performing a critical role in tumor initiation, progression, and metastasis of many cancers, including breast cancer. The breast cancer microenvironment is a complex mixture of cells consisting of tumor cells, immune cells, fibroblasts, and vascular cells, as well as noncellular components, such as extracellular matrix and soluble products. The interactions between the tumor cells and the tumor microenvironment modulate tumor behavior and affect the responses of cancer patients to therapies. The interactions between tumor cells and the surrounding en

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Graim, Kiley. "Abstract 5030: Intra-patient tumor evolution analysis in dogs with many mammary tumors identifies signatures of tumor aggression in early-stage breast cancers." Cancer Research 82, no. 12_Supplement (2022): 5030. http://dx.doi.org/10.1158/1538-7445.am2022-5030.

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Abstract Despite tremendous improvements in breast cancer detection, it remains unclear which early-stage tumors will later become aggressive. Dogs provide a unique opportunity to unravel early-stage tumor evolution, as dogs frequently develop multiple naturally occurring mammary tumors. To identify which early-stage human breast tumors will later become malignant, we analyzed mutational profiles of mammary tumors from two canine cohorts to identify patterns of tumor evolution. We compared our dog tumor signatures with human breast cancers. We found that dogs and humans share many known cancer

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Avagliano, Angelica, Giuseppe Fiume, Maria Rosaria Ruocco, et al. "Influence of Fibroblasts on Mammary Gland Development, Breast Cancer Microenvironment Remodeling, and Cancer Cell Dissemination." Cancers 12, no. 6 (2020): 1697. http://dx.doi.org/10.3390/cancers12061697.

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The stromal microenvironment regulates mammary gland development and tumorigenesis. In normal mammary glands, the stromal microenvironment encompasses the ducts and contains fibroblasts, the main regulators of branching morphogenesis. Understanding the way fibroblast signaling pathways regulate mammary gland development may offer insights into the mechanisms of breast cancer (BC) biology. In fact, the unregulated mammary fibroblast signaling pathways, associated with alterations in extracellular matrix (ECM) remodeling and branching morphogenesis, drive breast cancer microenvironment (BCM) rem

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40

Vazquez, Eliza, Yulia Lipovka, Alejandro Cervantes-Arias, et al. "Canine Mammary Cancer: State of the Art and Future Perspectives." Animals 13, no. 19 (2023): 3147. http://dx.doi.org/10.3390/ani13193147.

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Mammary cancer is the most frequently diagnosed neoplasia in women and non-spayed female dogs and is one of the leading causes of death in both species. Canines develop spontaneous mammary tumors that share a significant number of biological, clinical, pathological and molecular characteristics with human breast cancers. This review provides a detailed description of the histological, molecular and clinical aspects of mammary cancer in canines; it discusses risk factors and currently available diagnostic and treatment options, as well as remaining challenges and unanswered questions. The incid

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Singh, Jacqulene Sunder, Purna Joshi, and Emma Unger. "Abstract PO4-28-02: Adipocyte Progenitor-Mediated Effects on Mammary Cancer Cells." Cancer Research 84, no. 9_Supplement (2024): PO4–28–02—PO4–28–02. http://dx.doi.org/10.1158/1538-7445.sabcs23-po4-28-02.

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Abstract Treatment challenges in breast cancer arise from significant heterogeneity found within breast tumors and the surrounding microenvironment. The tumor microenvironment presents a complex ecosystem which comprises diverse stromal cells including immune, endothelial and fibroblast cell lineages and the extracellular matrix that support tumor progression. Adipocytes represent an abundant cell population in the normal breast and prior studies have reported a crosstalk between adipocytes and mammary cancer cells. De-differentiation of adipocytes into adipocyte progenitor-like cells is linke

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Johnstone, Megan, Ashley Leck, Taylor Lange, and Lisa Privette Vinnedge. "Abstract A084: DEK overexpression in the murine mammary gland promotes epithelial hyperplasia." Cancer Research 84, no. 3_Supplement_1 (2024): A084. http://dx.doi.org/10.1158/1538-7445.advbc23-a084.

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Abstract Introduction: Breast cancer (BC) remains a leading cause of cancer-associated mortality for women in the USA, which makes it critically important to identify and study molecular drivers of pathogenesis. We have previously identified the chromatin modifying DEK protein to have oncogenic properties. DEK is a histone H3 chaperone that is over-expressed in over 60% of breast cancers, particularly triple negative breast cancers, and is associated with poor survival. To date, all studies regarding the role of DEK in BC have manipulated DEK expression in cultured immortalized MCF10A human ma

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Munteanu, Camelia, and Bianca Pop. "The link between mammary cancer, excessive adipose tissue and cholesterol." Cluj Veterinary Journal 26, no. 3 (2021): 21–27. http://dx.doi.org/10.52331/cvj.v26i3.35.

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Mammary cancer remains the most frequent worldwide type of cancer in females. From a health point of view, it is a huge challenge. As a definition, we can say that a group of biologically and molecularly heterogeneous diseases is represented by mammary cancer. An important causal factor for this disease is genetic predisposition, especially mutations in the BRCA1 or BRCA2 gene. The mammary gland is stimulated by hormones both morphologically and physiologically. The most significant of these are estrogens. Estrogen is the main female hormone, but it is present in both females and males.

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Brisson, Lucie, Stéphanie Chadet, Osbaldo Lopez-Charcas, et al. "P2X7 Receptor Promotes Mouse Mammary Cancer Cell Invasiveness and Tumour Progression, and Is a Target for Anticancer Treatment." Cancers 12, no. 9 (2020): 2342. http://dx.doi.org/10.3390/cancers12092342.

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The P2X7 receptor is an ATP-gated cation channel with a still ambiguous role in cancer progression, proposed to be either pro- or anti-cancerous, depending on the cancer or cell type in the tumour. Its role in mammary cancer progression is not yet defined. Here, we show that P2X7 receptor is functional in highly aggressive mammary cancer cells, and induces a change in cell morphology with fast F-actin reorganization and formation of filopodia, and promotes cancer cell invasiveness through both 2- and 3-dimensional extracellular matrices in vitro. Furthermore, P2X7 receptor sustains Cdc42 activ

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Tavera-Mendoza, Luz E., and Myles Brown. "A less invasive method for orthotopic injection of breast cancer cells into the mouse mammary gland." Laboratory Animals 51, no. 1 (2016): 85–88. http://dx.doi.org/10.1177/0023677216640706.

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Breast cancer is the most common type of cancer diagnosed in women, and the second most common cause of cancer-related deaths in women in North America. The use of laboratory mice in research is an essential tool for the study of breast cancer biology and for pre-clinical therapeutic development. While subcutaneous flank injections of cancer cells are widely used for studying breast cancer biology and for exploring novel therapies, orthotopic xenografting of tumors into the mouse mammary gland allow for the study of breast cancers in a biologically relevant microenvironment. In this study we r

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Zheng, Yuanning, Linjie Luo, Isabel U. Lambertz, Claudio J. Conti, and Robin Fuchs-Young. "Early Dietary Exposures Epigenetically Program Mammary Cancer Susceptibility through Igf1-Mediated Expansion of the Mammary Stem Cell Compartment." Cells 11, no. 16 (2022): 2558. http://dx.doi.org/10.3390/cells11162558.

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Diet is a critical environmental factor affecting breast cancer risk, and recent evidence shows that dietary exposures during early development can affect lifetime mammary cancer susceptibility. To elucidate the underlying mechanisms, we used our established crossover feeding mouse model, where exposure to a high-fat and high-sugar (HFHS) diet during defined developmental windows determines mammary tumor incidence and latency in carcinogen-treated mice. Mammary tumor incidence is significantly increased in mice receiving a HFHS post-weaning diet (high-tumor mice, HT) compared to those receivin

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Wang, Yu. "Modulation of breast cancer development in MMTV-PyVT mice by adiponectin: A perspective on tumor microenvironment." Journal of Clinical Oncology 33, no. 28_suppl (2015): 34. http://dx.doi.org/10.1200/jco.2015.33.28_suppl.34.

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34 Background: The survival and growth of epithelial carcinoma cells are critically dependent on the interactions with the neighboring stromal cells. Adiponectin, a molecule exclusively produced by adipose tissue, possesses potent anti-inflammatory and anti-tumorigenic activities. Its expression and production are inversely associated with breast cancer risks in pre- and post-menopausal women. Reduced or completely loss of adiponectin expression enhances the development of mammary tumors in MMTV-PyVT mice. Despite these evidences, the mechanisms underlying the anti-breast cancer activity of ad

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Kultaev, A., and I. Zakiryarov. "S-DETECT FUNCTION AS THE LATEST METHOD OF ULTRASOUND EXAMINATION OF MAMMARY GLAND FORMATIONS: COMPARATIVE CHARACTERISTICS." Oncologia i radiologia Kazakhstana 66, no. 4 (2022): 24–32. http://dx.doi.org/10.52532/2663-4864-2022-4-66-24-32.

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Relevance: Worldwide, mammary gland formations remain a public health dilemma. Breast cancer (BC) is one of the leading causes of cancer mortality. Breast cancer ranked 3rd with 8.7-8.1% in the structure of malignant disease mortality in Kazakhstan in 2018-2019. Female breast cancer is the most common cancer. Over 2.2 million cases of breast cancer were registered in 2020, according to the WHO. Worldwide, breast cancer ranks fifth among the causes of mortality (685,000 deaths per year). On average, about 3,000 breast cancer cases are detected yearly in the Republic of Kazakhstan, a

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Wicker, Madison, and Kay-Uwe Wagner. "Cellular Plasticity in Mammary Gland Development and Breast Cancer." Cancers 15, no. 23 (2023): 5605. http://dx.doi.org/10.3390/cancers15235605.

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Cellular plasticity is a phenomenon where cells adopt different identities during development and tissue homeostasis as a response to physiological and pathological conditions. This review provides a general introduction to processes by which cells change their identity as well as the current definition of cellular plasticity in the field of mammary gland biology. Following a synopsis of the evolving model of the hierarchical development of mammary epithelial cell lineages, we discuss changes in cell identity during normal mammary gland development with particular emphasis on the effect of the

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Widowati, Wahyu, Diana Krisanti Jasaputra, Yusuf Heriady, et al. "Case Study: Heterogeneity of and CD44+/CD24- Cancer Stem Cell Subpopulation of Breast Cancer Patients in Bandung, Indonesia." Trends in Sciences 21, no. 7 (2024): 7437. http://dx.doi.org/10.48048/tis.2024.7437.

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Breast cancer (BC) cells characteristics have played a crucial role in clinical strategies decision-making and patient outcome prediction. Although there have been several studies examining this, there are still relatively few that analyze stem cell subpopulations or protein biomarkers. The conducted research sought to elucidate breast cancer subtype characteristics based on immunohistochemical analysis and cancer stem cell presence based on flow cytometry analysis in three breast cancer samples from Bandung, Indonesia. A flow cytometry analysis was conducted to determine how much CD44/CD24 wa

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