Academic literature on the topic 'Mammary gland involution'

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Journal articles on the topic "Mammary gland involution"

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Dickson, S. R., and M. J. Warburton. "Enhanced synthesis of gelatinase and stromelysin by myoepithelial cells during involution of the rat mammary gland." Journal of Histochemistry & Cytochemistry 40, no. 5 (1992): 697–703. http://dx.doi.org/10.1177/40.5.1315355.

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During the involution of the mammary gland there is destruction of the basement membrane as the secretory alveolar structures degenerate. Immunofluorescence staining of sections of rat mammary gland with antibodies to 72 KD gelatinase (MMP-2) and stromelysin (MMP-3) revealed increased production of these two proteinases during involution. This increased expression was mostly restricted to myoepithelial cells. Increased expression during involution was also demonstrated by immunoblotting techniques. Gelatin zymography indicated that the predominant metalloproteinase present in involuting rat ma
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Lund, L. R., S. F. Bjorn, M. D. Sternlicht, et al. "Lactational competence and involution of the mouse mammary gland require plasminogen." Development 127, no. 20 (2000): 4481–92. http://dx.doi.org/10.1242/dev.127.20.4481.

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Urokinase-type plasminogen activator expression is induced in the mouse mammary gland during development and post-lactational involution. We now show that primiparous plasminogen-deficient (Plg(−/−)) mice have seriously compromised mammary gland development and involution. All mammary glands were underdeveloped and one-quarter of the mice failed to lactate. Although the glands from lactating Plg(−/−) mice were initially smaller, they failed to involute after weaning, and in most cases they failed to support a second litter. Alveolar regression was markedly reduced and a fibrotic stroma accumul
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Talhouk, R. S., M. J. Bissell, and Z. Werb. "Coordinated expression of extracellular matrix-degrading proteinases and their inhibitors regulates mammary epithelial function during involution." Journal of Cell Biology 118, no. 5 (1992): 1271–82. http://dx.doi.org/10.1083/jcb.118.5.1271.

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Extracellular matrix (ECM) plays an important role in the maintenance of mammary epithelial differentiation in culture. We asked whether changes in mouse mammary specific function in vivo correlate with changes in the ECM. We showed, using expression of beta-casein as a marker, that the temporal expression of ECM-degrading proteinases and their inhibitors during lactation and involution are inversely related to functional differentiation. After a lactation period of 9 d, mammary epithelial cells maintained beta-casein expression up to 5 d of involution. Two metalloproteinases, 72-kD gelatinase
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Tian, Lei, Shancheng Guo, Zhiye Zhao, et al. "miR-30a-3p Regulates Autophagy in the Involution of Mice Mammary Glands." International Journal of Molecular Sciences 24, no. 18 (2023): 14352. http://dx.doi.org/10.3390/ijms241814352.

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The mammary gland undergoes intensive remodeling during the lactation cycle, and the involution process of mammary gland contains extensive epithelial cells involved in the process of autophagy. Our studies of mice mammary glands suggest that miR-30a-3p expression was low during involution compared with its high expression in the mammary glands of lactating mice. Then, we revealed that miR-30a-3p negatively regulated autophagy by autophagy related 12 (Atg12) in mouse mammary gland epithelial cells (MMECs). Restoring ATG12, knocking down autophagy related 5 (Atg5), starvation, and Rapamycin wer
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Batan, Sonia, Jabunnesa Khanom, Sabarish Ramachandran, et al. "Abstract P3-04-04: The Butyrate Transporter SLC5A8 Selectively Inhibits Breast Tumor Metastasis." Clinical Cancer Research 31, no. 12_Supplement (2025): P3–04–04—P3–04–04. https://doi.org/10.1158/1557-3265.sabcs24-p3-04-04.

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Abstract Introduction: The mammary gland is a dynamic organ that undergoes significant developmental changes during pregnancy, lactation, and involution. The process of involution is a highly orchestrated series of molecular and physical events that can be divided into two distinct phases. (Lund et al., 1996). Accumulation of milk in the alveolar lumen (milk stasis) is required to initiate the first phase during which the secretory cells begin to enter apoptosis. Here we provide genetic and molecular biological evidence to shows that the short-chain fatty acid Butyrate (BTR), a significant com
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Schwertfeger, Kathryn L., Monica M. Richert, and Steven M. Anderson. "Mammary Gland Involution Is Delayed by Activated Akt in Transgenic Mice." Molecular Endocrinology 15, no. 6 (2001): 867–81. http://dx.doi.org/10.1210/mend.15.6.0663.

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Abstract Activation of the antiapoptotic protein kinase Akt is induced by a number of growth factors that regulate mammary gland development. Akt is expressed during mammary gland development, and expression decreases at the onset of involution. To address Akt actions in mammary gland development, transgenic mice were generated expressing constitutively active Akt in the mammary gland under the control of the mouse mammary tumor virus (MMTV) promoter. Analysis of mammary glands from these mice reveals a delay in both involution and the onset of apoptosis. Expression of tissue inhibitor of meta
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Bernhardt, Sarah M., and Pepper Schedin. "Abstract B011: The anti-cancer effects of vitamin D are blocked postpartum, due to suppression of vitamin D metabolism in the involuting liver." Cancer Prevention Research 15, no. 12_Supplement_1 (2022): B011. http://dx.doi.org/10.1158/1940-6215.dcis22-b011.

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Abstract Postpartum mammary gland involution is a physiologic window of increased breast cancer risk. It has been proposed that the poor prognosis associated with postpartum breast cancer is due to the involuting mammary microenvironment promoting progression of indolent lesions to invasive disease. As such, the involuting gland has been implicated as a target for preventive strategies. Vitamin D has anti-cancer properties, and there are data demonstrating that vitamin D supplementation protects against breast cancer progression in mouse models. Moreover, vitamin D deficiency is prevalent in p
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Jena, Manoj Kumar, and Ashok Kumar Mohanty. "NEW INSIGHTS OF MAMMARY GLAND DURING DIFFERENT STAGES OF DEVELOPMENT." Asian Journal of Pharmaceutical and Clinical Research 10, no. 11 (2017): 35. http://dx.doi.org/10.22159/ajpcr.2017.v10i11.20801.

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Mammary gland is a unique organ with its function of milk synthesis, secretion, and involution to prepare the gland for subsequent lactation. The mammary epithelial cells proliferate, differentiate, undergo apoptosis, and tissue remodeling following a cyclic pathway in lactation – involution – lactation cycle, thus fine tuning the molecular events through hormones, and regulatory molecules. Several studies are performed on the mammary gland development, lactogenesis, and involution process in molecular details. The developmental stages of mammary gland are embryonic, pre-pubertal, pubertal, pr
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Atabai, Kamran, Rafael Fernandez, Xiaozhu Huang, et al. "Mfge8 Is Critical for Mammary Gland Remodeling during Involution." Molecular Biology of the Cell 16, no. 12 (2005): 5528–37. http://dx.doi.org/10.1091/mbc.e05-02-0128.

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Apoptosis is a critical process in normal mammary gland development and the rapid clearance of apoptotic cells prevents tissue injury associated with the release of intracellular antigens from dying cells. Milk fat globule-EGF-factor 8 (Mfge8) is a milk glycoprotein that is abundantly expressed in the mammary gland epithelium and has been shown to facilitate the clearance of apoptotic lymphocytes by splenic macrophages. We report that mice with disruption of Mfge8 had normal mammary gland development until involution. However, abnormal mammary gland remodeling was observed postlactation in Mfg
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Rivera, Olivia C., Stephen R. Hennigar, and Shannon L. Kelleher. "ZnT2 is critical for lysosome acidification and biogenesis during mammary gland involution." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 315, no. 2 (2018): R323—R335. http://dx.doi.org/10.1152/ajpregu.00444.2017.

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Mammary gland involution, a tightly regulated process of tissue remodeling by which a lactating mammary gland reverts to the prepregnant state, is characterized by the most profound example of regulated epithelial cell death in normal tissue. Defects in the execution of involution are associated with lactation failure and breast cancer. Initiation of mammary gland involution requires upregulation of lysosome biogenesis and acidification to activate lysosome-mediated cell death; however, specific mediators of this initial phase of involution are not well described. Zinc transporter 2 [ZnT2 ( SL
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Dissertations / Theses on the topic "Mammary gland involution"

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Hughes, Katherine. "Inflammation and remodelling in mammary gland involution." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607688.

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Kreuzaler, Peter Anton. "Cell death modalities in mammary gland involution." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609378.

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Treisman, Loren Lee. "The role of the PARbZips in mammary gland involution." Thesis, University of Cambridge, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.614361.

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Charifou, Elsa. "Characterization and impact of cellular senescence during mammary gland involution." Electronic Thesis or Diss., Sorbonne université, 2022. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2022SORUS559V2.pdf.

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La sénescence est une réponse à un stress biologique, caractérisée par un arrêt stable du cycle cellulaire. Néanmoins, les cellules restent métabolliquement actives et acquièrent un phenotype sécrétoire associé à la sénescence, avec la production d’un sécrétome complexe composé de cytokines, chémiokines, facteurs de croissance et modulateurs du remodelage de la matrice extracellulaire. La sénescence est associée à de nombreux processus pathologiques, comme la tumorigénèse et le vieillessement. Cependant, où, quand et comment la sénescence contribue aux processus physiologiques reste méconnu. P
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Staniszewska, Anna Dominika. "Roles of Stat3 in mammary gland development, involution and breast cancer." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610277.

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Anderson, Torri R. "Determination of expression of Fliz1 during involution of the mouse mammary gland." Thesis, Villanova University, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1565164.

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<p> Remodeling of the mouse mammary gland is a highly coordinated process that occurs after the removal of suckling pups from the mother. Involution, or shrinking of the mammary gland, after removal of the pups has been linked to apoptotic events within the mouse mammary tissue during forced weaning. Several transcription factors are hypothesized to be involved in this process. A transcription factor known as GATA-3, which was first identified in the thymus, is also important for maintenance of various tissue types within the mouse mammary gland; its loss leads to epithelial cell detachment an
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Marshall, Aaron. "The Biology of Mammary Gland Serotonin Synthesis and Transport." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1251229830.

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Pai, Vaibhav Prakash. "Serotonin Regulation of Mammary Gland Involution and its Role in Breast Cancer Progression." University of Cincinnati / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1237565289.

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Patel, Amita. "Transcriptional regulation of cathepsin L during mouse mammary gland involution a test of STAT3 involvement /." Click here for download, 2006. http://wwwlib.umi.com/cr/villanova/fullcit?p1432835.

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Stairiker, Patricia A. "The role of L in involution and the termination of lactation in the mouse mammary gland." Click here for download, 2007. http://proquest.umi.com/pqdweb?did=1075710531&sid=3&Fmt=2&clientId=3260&RQT=309&VName=PQD.

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Books on the topic "Mammary gland involution"

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Hojilla, Carlo Vincent. The role of TIMP3 in mammary gland morphogenesis, involution, inflammation, and tumourigenesis. 2006.

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Wang, Ruijia. The role of apoptosis in development of mouse mammary gland: Expression of Pl3K/AKT/bad pathway in development, diffentiation, pregnancy, lactation and involution of mouse mammary gland. 1999.

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Book chapters on the topic "Mammary gland involution"

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Marti, Andreas, Hans Graber, Hedvika Lazar, et al. "Caspases: Decoders of Apoptotic Signals During Mammary Involution." In Biology of the Mammary Gland. Springer US, 2002. http://dx.doi.org/10.1007/0-306-46832-8_24.

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Bielke, Wolfgang, Guo Ke, Robert Strange, and Robert Friis. "Apoptosis in Mammary Gland Involution: Isolation and Characterization of Apoptosis-Specific Genes." In Intercellular Signalling in the Mammary Gland. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1973-7_5.

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Monaghan, Paul, Nina Perusinghe, and W. Howard Evans. "Dramatic Changes in Gap Junction Expression in the Mammary Gland During Pregnancy, Lactation and Involution." In Intercellular Signalling in the Mammary Gland. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1973-7_37.

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Fetherston, Catherine M., Chee Seong Lee, and Peter E. Hartmann. "Mammary Gland Defense: The Role of Colostrum, Milk and Involution Secretion." In Advances in Nutritional Research Volume 10. Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0661-4_8.

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Tonner, Elizabeth, James Beattie, and David J. Flint. "Production of an Insulin-Like Growth Factor Binding Protein by the Involuting Rat Mammary Gland." In Intercellular Signalling in the Mammary Gland. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4615-1973-7_25.

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Lloyd-Lewis, Bethan, Timothy J. Sargeant, Peter A. Kreuzaler, Henrike K. Resemann, Sara Pensa, and Christine J. Watson. "Analysis of the Involuting Mouse Mammary Gland: An In Vivo Model for Cell Death." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-6475-8_7.

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Hurley, W. L. "MAMMARY GLAND | Growth, Development, Involution." In Encyclopedia of Dairy Sciences. Elsevier, 2002. http://dx.doi.org/10.1016/b0-12-227235-8/00278-9.

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Hurley, W. L., and J. J. Loor. "Mammary Gland | Growth, Development and Involution." In Encyclopedia of Dairy Sciences. Elsevier, 2011. http://dx.doi.org/10.1016/b978-0-12-374407-4.00291-0.

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Loor, J. J., F. Batistel, M. Bionaz, W. L. Hurley, and E. Vargas-Bello-Pérez. "Mammary Gland: Gene Networks Controlling Development and Involution." In Reference Module in Food Science. Elsevier, 2020. http://dx.doi.org/10.1016/b978-0-12-818766-1.00001-5.

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Loor, J. J., F. Batistel, M. Bionaz, and W. L. Hurley. "Mammary Gland: Gene Networks Controlling Development and Involution." In Reference Module in Food Science. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-08-100596-5.00883-0.

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Conference papers on the topic "Mammary gland involution"

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Garofalo, Jennifer-Marie, Dawn Bowers, Richard Browne, Brian MacQueen, Terry Mashtare, and Patricia A. Masso-Welch. "Abstract 5460: Effects of ethanol exposure during involution on mouse mammary gland." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-5460.

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Ramachandran, Sabarish, Selvakumar Elangovan, Puttur D. Prasad, Vadivel Ganapathy, and Muthusamy Thangaraju. "Abstract LB-236: Differential regulation of STAT3 in mammary gland involution as well as in mammary tumorigeneis." In Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC. American Association for Cancer Research, 2010. http://dx.doi.org/10.1158/1538-7445.am10-lb-236.

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Martinson, Holly, Sonail Jindal, Virginia Borges, and Pepper Schedin. "Abstract A31: Immune cell influx during postpartum mammary gland involution reveals immunosuppression and tumor promotion." In Abstracts: AACR Special Conference on Tumor Invasion and Metastasis - January 20-23, 2013; San Diego, CA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.tim2013-a31.

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Lyons, Traci R., Virginia F. Borges, Courtney B. Betts, et al. "Abstract B099: Postpartum mammary gland involution promotes COX-2 dependent tumor cell invasion of lymphatics." In Abstracts: AACR Special Conference on Advances in Breast Cancer Research: Genetics, Biology, and Clinical Applications - October 3-6, 2013; San Diego, CA. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1557-3125.advbc-b099.

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Ramachandran, Sabarish, Selvakumar Elangovan, Rajneesh Pathania, Puttur Devi Prasad, Vadivel Ganapathy, and Muthusamy Thangaraju. "Abstract 18: Slc5a8 inactivation is associated with mammary gland involution delay, early onset of mammary tumorigenesis and accelerated lung metastasis." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-18.

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Guo, Qiuchen, and Pepper J. Schedin. "Abstract LB-009: Collagen regulation in postpartum mammary gland involution, a novel breast cancer prevention target." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-lb-009.

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Cook, Katherine L., Anni Warri, Rong Hu, et al. "Abstract 1667: Autophagy and unfolded protein response (UPR) signaling regulates progression of apoptosis in mammary gland involution." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-1667.

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Vallone, Sabrina A., Martín García Solá, Robert D. Cardiff, et al. "Abstract 3685: Sustained Ret expression during mammary gland post-lactation induces premature involution and enhances cancer potential." In Proceedings: AACR Annual Meeting 2020; April 27-28, 2020 and June 22-24, 2020; Philadelphia, PA. American Association for Cancer Research, 2020. http://dx.doi.org/10.1158/1538-7445.am2020-3685.

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Shinde, Neelam, Kirti Kaul, Allen Zhang, et al. "Abstract PS17-28: Abrupt involution of lactating mammary gland induces metabolic reprogramming conducive to pro-tumorigenic changes." In Abstracts: 2020 San Antonio Breast Cancer Virtual Symposium; December 8-11, 2020; San Antonio, Texas. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.sabcs20-ps17-28.

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Lyons, Traci R., Jenean O'Brien, Matthew Conklin, Patricia Keely, Virginia Borges, and Pepper Schedin. "Abstract B61: Postpartum mammary gland involution drives DCIS progression through collagen and COX-2, identifying a target for intervention." In Abstracts: AACR International Conference on Frontiers in Cancer Prevention Research‐‐ Oct 22-25, 2011; Boston, MA. American Association for Cancer Research, 2011. http://dx.doi.org/10.1158/1940-6207.prev-11-b61.

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Reports on the topic "Mammary gland involution"

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Cowin, Pamela. Targeting the Prometastatic Microenvironment of the Involuting Mammary Gland. Defense Technical Information Center, 2014. http://dx.doi.org/10.21236/ada612509.

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